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Search of human proteins with 34147403
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34147403 intraflagellar transport 81-like isoform 2 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34147403 intraflagellar transport 81-like isoform 2 [Homo sap... 834 0.0
gi|219555661 intraflagellar transport 81-like isoform 1 [Homo sa... 764 0.0
gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sap... 764 0.0
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 68 1e-11
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 67 3e-11
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 60 5e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 59 7e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 58 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 58 2e-08
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 58 2e-08
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 58 2e-08
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 57 2e-08
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 57 2e-08
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 57 2e-08
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 57 2e-08
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 57 2e-08
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 57 2e-08
gi|148746195 trichohyalin [Homo sapiens] 56 6e-08
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 56 6e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 56 7e-08
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 55 9e-08
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 55 9e-08
gi|55770834 centromere protein F [Homo sapiens] 55 9e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 55 1e-07
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 55 1e-07
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 54 2e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 54 4e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 54 4e-07
gi|221139761 zinc finger protein 853 [Homo sapiens] 53 5e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 53 5e-07
>gi|34147403 intraflagellar transport 81-like isoform 2 [Homo
sapiens]
Length = 431
Score = 834 bits (2154), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQDLTLSPRLECGGVIMAYCSLKL 420
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQDLTLSPRLECGGVIMAYCSLKL
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQDLTLSPRLECGGVIMAYCSLKL 420
Query: 421 LGSSDPPTSAS 431
LGSSDPPTSAS
Sbjct: 421 LGSSDPPTSAS 431
>gi|219555661 intraflagellar transport 81-like isoform 1 [Homo
sapiens]
Length = 676
Score = 764 bits (1974), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
Score = 37.4 bits (85), Expect = 0.027
Identities = 48/224 (21%), Positives = 101/224 (45%), Gaps = 38/224 (16%)
Query: 113 KKRAYLARFLIKLEVPSEF-LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFS-TAE 170
K + + I E+ +EF L T +++E + + +T+ E+ ISG+S T E
Sbjct: 407 KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTME---EKKGISGYSYTQE 463
Query: 171 IRKDISAMEEEKDQLIKRV-----EHLKKRVE-TAQNHQWMLKIARQLRVEKEREEYLAQ 224
+ +SA++ E D++ R E +KK ++ + + ++LR +++ + L Q
Sbjct: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523
Query: 225 QKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKP------------ESLMKRLEE 268
+ E+K+Q L+ +++ +++ +R+ + E ++R +
Sbjct: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583
Query: 269 EIKFNL--------YMVTEKFPK---ELENKKKELHFLQKVVSE 301
E+K + + E++ K E EN K+L QKV+ E
Sbjct: 584 EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
>gi|32526901 intraflagellar transport 81-like isoform 1 [Homo
sapiens]
Length = 676
Score = 764 bits (1974), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ
Sbjct: 1 MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQ 60
Query: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR
Sbjct: 61 TAKRMLSLLGILKYKPSGNATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLAR 120
Query: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
Query: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
Query: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
Query: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
Score = 37.4 bits (85), Expect = 0.027
Identities = 48/224 (21%), Positives = 101/224 (45%), Gaps = 38/224 (16%)
Query: 113 KKRAYLARFLIKLEVPSEF-LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFS-TAE 170
K + + I E+ +EF L T +++E + + +T+ E+ ISG+S T E
Sbjct: 407 KSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLQTME---EKKGISGYSYTQE 463
Query: 171 IRKDISAMEEEKDQLIKRV-----EHLKKRVE-TAQNHQWMLKIARQLRVEKEREEYLAQ 224
+ +SA++ E D++ R E +KK ++ + + ++LR +++ + L Q
Sbjct: 464 ELERVSALKSEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQLRQKYQELTQ 523
Query: 225 QKQEQKNQLFHAVQRLQ----RVQNQLKSMRQAAADAKP------------ESLMKRLEE 268
+ E+K+Q L+ +++ +++ +R+ + E ++R +
Sbjct: 524 ECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNLEVQLRRATD 583
Query: 269 EIKFNL--------YMVTEKFPK---ELENKKKELHFLQKVVSE 301
E+K + + E++ K E EN K+L QKV+ E
Sbjct: 584 EMKAYISSDQQEKRKAIREQYTKNTAEQENLGKKLREKQKVIRE 627
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 68.2 bits (165), Expect = 1e-11
Identities = 69/270 (25%), Positives = 127/270 (47%), Gaps = 31/270 (11%)
Query: 142 KQYEEL-MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA- 199
KQ E L E L +QL+++ + + ++ + EK +L ++VE L+ VETA
Sbjct: 604 KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR 663
Query: 200 -QNHQWMLKIAR---QLRVEKER---EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252
+ H+ ++A QLR E+++ +E +AQ+K + + QL + L+ + L+ ++
Sbjct: 664 QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723
Query: 253 AAADAKPESLMKRLEEEIKFNLYMVTEKFP---KELENKKKELHFLQKVVSEPAMGHS-- 307
AADA E +R E+K + E+ KELE ++ L+ + + H
Sbjct: 724 RAADALEEQ--QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAE 781
Query: 308 ------DLLELESKINEINTEINQLIEKKMMRNEPIEGKL-------SLYRQQASIISRK 354
+L E + + +E QL+++ E E +++++Q + +
Sbjct: 782 TEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE 841
Query: 355 KEAKAEELQEAKEKLASLE--REASVKRNQ 382
E +ELQEAKEK+A +E E + R Q
Sbjct: 842 CEKARQELQEAKEKVAGIESHSELQISRQQ 871
Score = 49.7 bits (117), Expect = 5e-06
Identities = 76/329 (23%), Positives = 141/329 (42%), Gaps = 39/329 (11%)
Query: 80 ATDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVAD 139
A D+ST ++ + SK V L L+++ E ++ A +R L+K + Q E + +
Sbjct: 899 ADDLSTLQEKMAATSKEVAR--LETLVRKAGEQQETA--SRELVKEPARAGDRQPEWLEE 954
Query: 140 TN-KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDI----SAMEEEKDQLIKRVEHLKK 194
+Q+ A + + +E EQ+ G +R + +EE+ Q + V L +
Sbjct: 955 QQGRQFCSTQAALQAMEREAEQM---GNELERLRAALMESQGQQQEERGQQEREVARLTQ 1011
Query: 195 RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQE---QKNQLFHAVQRLQRVQNQLKSMR 251
AQ + K AR +E + L +Q+ E + L HA+ + +L +R
Sbjct: 1012 ERGRAQADLALEKAARA-ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
Query: 252 QAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE 311
A + +K LEE L ++ ++L K+KE H A G ++
Sbjct: 1071 GLEA-----AQIKELEE-----LRQTVKQLKEQLAKKEKE-HASGSGAQSEAAGRTE--P 1117
Query: 312 LESKINEINTEINQLIEKKMMRNEPIEG-KLSLYRQQASIISRKK---------EAKAEE 361
K+ + E+++L ++ + E + + SL ++AS R E KA+E
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
Query: 362 LQEAKEKLASLEREASVKRNQTREFDGTE 390
L ++ LAS +RE + R + ++ E
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Score = 42.7 bits (99), Expect = 6e-04
Identities = 50/206 (24%), Positives = 99/206 (48%), Gaps = 17/206 (8%)
Query: 103 HWLLQRTNE-LKKRAYLARFLIKLEVPS---EFLQDETV--ADTNKQYEELMEAFKTLHK 156
H LL N L +RA L R +++E+ +++Q+ AD + E+ ++ +
Sbjct: 1444 HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAR 1503
Query: 157 EYEQL--KISGFSTAEIRKDISAMEEEKDQLIKRVEHLK--KRVETAQNHQWMLKIARQL 212
E E + K G + ++ ++ +EE+ +L +VE L+ +R +T Q + K+A
Sbjct: 1504 ELEVMTAKYEG-AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSD 1562
Query: 213 RVEKEREEYL-AQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK 271
+ K +++ L A Q Q ++Q Q QR+Q QL ++ + + + +L+ E
Sbjct: 1563 QASKVQQQKLKAVQAQGGESQ-----QEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617
Query: 272 FNLYMVTEKFPKELENKKKELHFLQK 297
Y ++ +EL+ + + L LQK
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQLQK 1643
Score = 38.1 bits (87), Expect = 0.016
Identities = 50/248 (20%), Positives = 106/248 (42%), Gaps = 23/248 (9%)
Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQK 230
++++ + + QL RVE L ET + Q +A + E+E+ QQ
Sbjct: 418 LKQEAATLAANNTQLQARVEML----ETERGQQEAKLLAERGHFEEEK-----QQLSSLI 468
Query: 231 NQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKK 290
L ++ L + + +L+ QA A+ + + L E+ L ++ +EL K+
Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHG-ARLTAQVASLTSELT-TLNATIQQQDQELAGLKQ 526
Query: 291 ELHFLQKVVSEPAMGHSDLLE-LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349
+ Q +++ + L ++ ++++ + Q ++ E E + QQ +
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586
Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVK----------RNQTREFDGTEVLKGDERQD 399
+ ++EA E A ++L +LE+E + K N+ R+ T V + +R+
Sbjct: 587 TAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA-QREK 645
Query: 400 LTLSPRLE 407
LS ++E
Sbjct: 646 AELSRKVE 653
Score = 35.8 bits (81), Expect = 0.077
Identities = 57/259 (22%), Positives = 110/259 (42%), Gaps = 43/259 (16%)
Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREE 220
L+ F ++K ++ +D+L +E A+N + + + Q+ + ++R +
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDEL---------ELELAENRKLLTEKDAQIAMMQQRID 259
Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEK 280
LA ++Q A L+ +L+ +R K ESL RL E +K + TEK
Sbjct: 260 RLALLNEKQ------AASPLE--PKELEELRD-----KNESLTMRLHETLKQCQDLKTEK 306
Query: 281 FP-----KELENKKKELHF-----------LQKVVSEPAMGHSDLL-ELESKINEINTEI 323
+L + +L F LQ ++E HS E K ++ E+
Sbjct: 307 SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKEL 366
Query: 324 NQLIEKKMM---RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE-ASVK 379
+ ++ K +NE ++GKLS + S + + E+ +L +L++E A++
Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426
Query: 380 RNQTREFDGTEVLKGDERQ 398
N T+ E+L+ + Q
Sbjct: 427 ANNTQLQARVEMLETERGQ 445
Score = 34.7 bits (78), Expect = 0.17
Identities = 69/322 (21%), Positives = 136/322 (42%), Gaps = 46/322 (14%)
Query: 101 VLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQ 160
VL +LQ ++ A LA +L+ E L+ T + +E + H E E+
Sbjct: 408 VLGDVLQLETLKQEAATLAANNTQLQARVEMLE------TERGQQEAKLLAERGHFEEEK 461
Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIK-----------RVEHLKKRVET--AQNHQWMLK 207
++S T +++ IS + + K++L + +V L + T A Q +
Sbjct: 462 QQLSSLIT-DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 208 IARQLRVEKEREEYLAQ--QKQEQKNQ-LFHAVQRL----QRVQNQLKSMRQ-------- 252
+A + KE++ LAQ Q+QEQ +Q L H V++L ++ + QLK + +
Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD 580
Query: 253 -----AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKV----VSEPA 303
A A + E+ ++ + +K + EK K LE +++L + +
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEKAAK-LEILQQQLQVANEARDSAQTSVT 639
Query: 304 MGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ 363
+ EL K+ E+ + +++ + +L L + + +KE A+E
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQV-AELELQLRSEQQKATEKERVAQEKD 698
Query: 364 EAKEKLASLEREASVKRNQTRE 385
+ +E+L +L+ V + E
Sbjct: 699 QLQEQLQALKESLKVTKGSLEE 720
Score = 32.0 bits (71), Expect = 1.1
Identities = 39/186 (20%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 211 QLRVEKEREEY---LAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRL- 266
++ +++ RE+Y LA + + + +L + Q +L+ M AK + L +R
Sbjct: 1466 EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR 1525
Query: 267 --EEEIKFN-----LYMVTEKFPKELENKKKEL-----------HFLQKVVSEPAMGHSD 308
EE K L + + K++E K+L L+ V ++ +
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE 1585
Query: 309 LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEK 368
L++++NE+ +++Q E Y+ Q +AK ++ QE +E+
Sbjct: 1586 AQRLQAQLNELQAQLSQK-----------EQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 369 LASLER 374
L SLE+
Sbjct: 1635 LRSLEQ 1640
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 67.0 bits (162), Expect = 3e-11
Identities = 64/257 (24%), Positives = 125/257 (48%), Gaps = 22/257 (8%)
Query: 141 NKQYEELMEAFKTLHKEY-EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199
N ++E++ AF+ K + EQ K E+ K I +E QL K+ + K++ +T
Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHK-------EMEKQIERLEA---QLEKKDQQFKEQEKTM 791
Query: 200 QNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP 259
Q + I +Q +E + L + K E K + + L+ +QNQ+ + +
Sbjct: 792 SMLQQDI-ICKQHHLES-LDRLLTESKGEMKKENMKKDEALKALQNQVSE--ETIKVRQL 847
Query: 260 ESLMKRLEEEIKFNLYMVT---EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316
+S ++ +EE+ +L + EKF K+L+ K +E++ LQK + + E +
Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907
Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIIS----RKKEAKAEELQEAKEKLASL 372
+ Q+++++ +RN +E + +Q S + +++E+ AE+L++ +EK S
Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967
Query: 373 EREASVKRNQTREFDGT 389
EA +KR + E GT
Sbjct: 968 AHEADLKRQKVIELTGT 984
Score = 53.9 bits (128), Expect = 3e-07
Identities = 59/261 (22%), Positives = 123/261 (47%), Gaps = 20/261 (7%)
Query: 115 RAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKD 174
R + + +IKLE E + E + + NKQ E L + L EQL+ F + ++
Sbjct: 1157 RGEMEQKIIKLEGTLEKSELE-LKECNKQIESLNDK---LQNAKEQLREKEFIMLQNEQE 1212
Query: 175 ISAMEEEKD---QLIKRVEHLKKRVET--AQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
IS +++E + Q +K +E + K E A ++ + + ++LR+ +E+ + + E
Sbjct: 1213 ISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAA--ADAKPESLMKRL------EEEIKFNLYMVTEKF 281
++Q A + ++R+ ++L+ M+Q + DA L + L E ++ + +K
Sbjct: 1273 RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332
Query: 282 PKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKL 341
E+E+ K+ H +++S + +S+ + + ++N+ +EK + E + +
Sbjct: 1333 SAEVESLKEAYH--MEMISHQENHAKWKISADSQKSSVQ-QLNEQLEKAKLELEEAQDTV 1389
Query: 342 SLYRQQASIISRKKEAKAEEL 362
S QQ + EA E L
Sbjct: 1390 SNLHQQVQDRNEVIEAANEAL 1410
Score = 49.3 bits (116), Expect = 7e-06
Identities = 66/292 (22%), Positives = 130/292 (44%), Gaps = 28/292 (9%)
Query: 133 QDETVADTNKQYEELME--AFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE 190
Q E+ A+ ++ EE E A + K + ++++G + +++ ++ +EE ++ K +
Sbjct: 949 QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG-TARQVKIEMDQYKEELSKMEKEIM 1007
Query: 191 HLKKRVETAQNHQWML-KIARQLRVEKERE----EYLAQQKQEQKNQLFHAVQR------ 239
HLK+ E H L I Q + E E++ + L + + + +L A+Q+
Sbjct: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLET 1067
Query: 240 -LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKF----NLYMVTEKFPKELENKKKELHF 294
LQ +LKS + + + +L E K+ +L + E+E+KK+EL
Sbjct: 1068 ELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE 1127
Query: 295 LQKVVSEP----AMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASI 350
+ + + E + + L+ I E E+ Q I K E E +L +Q
Sbjct: 1128 MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIES 1187
Query: 351 ISRKKEAKAEELQEAKEKLASLEREAS-----VKRNQTREFDGTEVLKGDER 397
++ K + E+L+E + + E+E S ++R Q R + V+K E+
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239
Score = 45.4 bits (106), Expect = 1e-04
Identities = 69/317 (21%), Positives = 141/317 (44%), Gaps = 57/317 (17%)
Query: 107 QRTNELKKRAYLARFLIKLEVPSEF-----LQDETVADTNKQ--YEELMEAFKTLHKEYE 159
Q EL+K+ + L KL+ +E LQ V +T Q + EL + L + +
Sbjct: 1029 QTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRD 1088
Query: 160 QLKISGFS-----------TAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI 208
L+ + S TAE+R+ +E++K +L++ + LK+R N + +
Sbjct: 1089 VLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKER-----NWELKQRA 1143
Query: 209 ARQLRVEKEREEYLAQQKQ---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAK-----PE 260
A+ ++ E+ + +Q + + L + L+ Q++S+ +AK E
Sbjct: 1144 AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKE 1203
Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEP----AMGHSDLLEL---- 312
+M + E+EI + KE+E ++ + ++ V+ E A + + ++L
Sbjct: 1204 FIMLQNEQEI--------SQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQEL 1255
Query: 313 ---ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAK----AEELQEA 365
++ +TE+ + +++ IE +LS + +S++K+A AEEL +
Sbjct: 1256 RLTREQVQNSHTELAEARHQQVQAQREIE-RLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
Query: 366 KEKLASLE--REASVKR 380
K + A LE +A +K+
Sbjct: 1315 KVREAHLEARMQAEIKK 1331
Score = 35.8 bits (81), Expect = 0.077
Identities = 51/267 (19%), Positives = 108/267 (40%), Gaps = 28/267 (10%)
Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKIS----GFSTAEIRKDISAMEEEKDQLIKR 188
Q+E + ++ E ++L K QL + GF + + +S+ ++D+ I
Sbjct: 492 QNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGC 551
Query: 189 VEHLKK-----RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL--- 240
E K R++ A + K+ L + + + ++ ++L
Sbjct: 552 CEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKL 611
Query: 241 --QRVQNQLKSMRQAAADAKPESLMKRLE---EEIKFNLYMVTEKFPKELENKKKELHFL 295
+V +K Q + + E +RL EE++ L + E EN +++
Sbjct: 612 GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI------EAENSDLKVNMA 665
Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
+ S+ + +LLE S +++ +E+ + + + + +E K+ Y S I+ K
Sbjct: 666 HRT-SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY----SSIAAKN 720
Query: 356 EAKAEELQEAKEKLASLEREASVKRNQ 382
+EL E EK+ SLE + + +
Sbjct: 721 AELEQELMEKNEKIRSLETNINTEHEK 747
Score = 35.4 bits (80), Expect = 0.10
Identities = 76/364 (20%), Positives = 136/364 (37%), Gaps = 93/364 (25%)
Query: 35 LQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLL----GILKYKP-------SGNATDM 83
LQ L + L+ + P + D P ++ K +L + G+L Y P SG++TD
Sbjct: 154 LQSLGEELSSVSPSENSDYAPN-PSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDF 212
Query: 84 STFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQ 143
+ + S + + L ++ N+L+++ A Q
Sbjct: 213 QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQN---------------------ACLVTQ 251
Query: 144 YEELMEAFKTLHKEYEQ--LKISGFSTAEIRK-DISAMEEEKDQLIKRVEHLKKRVETAQ 200
LM F+++H E Q K+S +A+ + + +EE+ L V K + A+
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAE 311
Query: 201 NHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPE 260
N L+ ++++ +EKE Q QE K + L L+ +Q
Sbjct: 312 NK---LEQSQKMVIEKE------QSLQESKEECIKLKVDL------LEQTKQG------- 349
Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
KR E + LY E + KKK L+KV +E + +L E +
Sbjct: 350 ---KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKE----- 401
Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
N+ ++ + LY+ + I+ KEKL L+ E + +
Sbjct: 402 -------------NKRLQERCGLYKSELEIL--------------KEKLRQLKEENNNGK 434
Query: 381 NQTR 384
+ R
Sbjct: 435 EKLR 438
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 59.7 bits (143), Expect = 5e-09
Identities = 58/251 (23%), Positives = 116/251 (46%), Gaps = 27/251 (10%)
Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
+TV + N + +L + LH++ EQ K G ++ +++ ++EE +L ++V L+
Sbjct: 597 QTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLET 656
Query: 195 RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAA 254
E + E E+ +Q Q + L ++ LQ V QL+ + +
Sbjct: 657 ATE-----------------KVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDN 699
Query: 255 ADAKPESL-MKRLEEEIKFNLYMVT--EKFPKELENKKKELHFLQKVVSEPAMG-HSDLL 310
E+L ++RL E ++F + E+ ++LE +K+EL + V A+G S+ L
Sbjct: 700 KQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELR--KNVDLLKALGKKSERL 757
Query: 311 ELE-SKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEA---KAEELQEAK 366
EL ++ N + Q +E + + +E +L + + R EA +L+ A+
Sbjct: 758 ELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAE 817
Query: 367 EKLASLEREAS 377
+ +LE+E +
Sbjct: 818 KDRKALEQEVA 828
Score = 40.8 bits (94), Expect = 0.002
Identities = 70/288 (24%), Positives = 128/288 (44%), Gaps = 47/288 (16%)
Query: 108 RTNELKKRAY-LARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
+ EL+K + L++ + KL+ E + ++ D EEL+ + L + E LK
Sbjct: 495 KCGELEKENHQLSKKIEKLQTQLE-REKQSNQDLETLSEELIREKEQLQSDMETLK---- 549
Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKERE--EYLAQ 224
A+ + I +E+EKD L + + L++R + + AR VEKE +
Sbjct: 550 --ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSE-------ARMKDVEKENKALHQTVT 600
Query: 225 QKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEE------IKFNLYMVT 278
+ + +QL ++L R Q K + A K E ++RL+EE +L T
Sbjct: 601 EANGKLSQLEFEKRQLHRDLEQAKEKGERA--EKLERELQRLQEENGRLARKVTSLETAT 658
Query: 279 EKFPK--------ELENK--KKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328
EK +LEN+ +K L LQ V + D +L+++ N E+ +L+E
Sbjct: 659 EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAE----NLELRRLVE 714
Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA 376
+ KL+ ++ + R+K EEL++ + L +L +++
Sbjct: 715 TMRFTST----KLAQMERENQQLEREK----EELRKNVDLLKALGKKS 754
Score = 32.7 bits (73), Expect = 0.65
Identities = 48/244 (19%), Positives = 105/244 (43%), Gaps = 39/244 (15%)
Query: 146 ELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWM 205
EL + L ++ E L+++ KD A+E+E QL E KK +E W
Sbjct: 791 ELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL----EKDKKLLEKEAKRLW- 845
Query: 206 LKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES-LMK 264
QQ + + L + +L V+ + +++ + A + + +K
Sbjct: 846 ------------------QQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK 887
Query: 265 RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324
LE++ + VT + L +++L L+K+ S+ +L S++++++ E+
Sbjct: 888 ELEKDNRDLTKQVT-VHARTLTTLREDL-VLEKLKSQ---------QLSSELDKLSQELE 936
Query: 325 QL-IEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQT 383
++ + ++++ E G + Y+ + R + A L +EK+ LE + K +
Sbjct: 937 KVGLNRELLLQEDDSGSDTKYK---ILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN 993
Query: 384 REFD 387
R+ +
Sbjct: 994 RQLE 997
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 59.3 bits (142), Expect = 7e-09
Identities = 60/278 (21%), Positives = 132/278 (47%), Gaps = 21/278 (7%)
Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170
ELK++ A+FL+ +V + LQ+E +Q EEL E K + K+ E++
Sbjct: 250 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 301
Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVE----KEREEYLAQQK 226
+R+ M E+++++ ++ + L+++ + + + L+ ++LR + +E+EE + +Q+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADA-----KPESLMKRLEEEIKFNLYMVT 278
+ EQ+ +++ +RL + Q++ Q D + + ++ EE ++ M
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421
Query: 279 EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI- 337
+ E K +E + E + E E K+ E + + EK + E +
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481
Query: 338 EGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
E + ++QQ ++K + E++QE +EK+ E +
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
Score = 46.2 bits (108), Expect = 6e-05
Identities = 52/260 (20%), Positives = 113/260 (43%), Gaps = 22/260 (8%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
++ E + E K + +E E ++ + +++ EE++ Q + E +K E +
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQ--------EQKNQLFHAVQRLQRVQNQLKSMRQA 253
+ KI Q +++EE Q+K+ EQ++Q++ ++++ + ++ +
Sbjct: 507 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 254 AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLL--- 310
E K ++E K M E+ +E E K +E + + E + +
Sbjct: 567 MEKKTQEQEKKTWDQEEK----MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
Query: 311 -----ELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365
E E K+ E ++ + EK + E + + L Q+ + +K + E++QE
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 366 KEKLASLEREASVKRNQTRE 385
+EK+ E+E K+ Q +E
Sbjct: 683 EEKI--WEQEKMEKKTQEQE 700
Score = 43.1 bits (100), Expect = 5e-04
Identities = 45/241 (18%), Positives = 109/241 (45%), Gaps = 38/241 (15%)
Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVE------------TAQNHQW-----MLKIARQ 211
AE+++ + E EK ++ V+ LK+++E T Q W + + ++
Sbjct: 228 AELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 287
Query: 212 LRVEKER----EEYLAQQK---QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMK 264
+R ++E+ EE L +Q+ +EQ+ +++ +RL+ + K +R+ + + + ++
Sbjct: 288 IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE---KELREQEKELREQKELR 344
Query: 265 RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324
EE+++ + E+ K E ++K ++ L E E ++ E ++
Sbjct: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER-----------LWEQEKQMREQEQKMR 393
Query: 325 QLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384
E+ ++E + K R+Q + + ++ + E+ + +EK + E + + R
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 385 E 385
E
Sbjct: 454 E 454
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/274 (18%), Positives = 119/274 (43%), Gaps = 21/274 (7%)
Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192
Q+E + D Q +++ + + + K+ ++ + + E ++ M E + ++ + E +
Sbjct: 549 QEEKMRD---QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
Query: 193 KKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQ---EQKNQLFHAVQRLQRVQNQLKS 249
+++ E Q + K+ Q E+EE + +Q++ EQ+ +++ +++ Q +
Sbjct: 606 REQEEKMQEQEE--KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
+ K + K E+E K EK +E E K + E +
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD--------QEKMREEESM 715
Query: 310 LELESKINEINTEINQLIEKKMMRNEPI-EGKLSLYRQQASIISRKKEA-KAEELQEAKE 367
E E K+ E + + EK + E + E + ++ Q+ + ++++ + + L E KE
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 368 KL---ASLEREASVKRNQTREFDGTEVLKGDERQ 398
KL ++ + + + + D E ++G E +
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809
Score = 36.2 bits (82), Expect = 0.059
Identities = 36/168 (21%), Positives = 77/168 (45%), Gaps = 9/168 (5%)
Query: 104 WLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKI 163
W QR E K++ + + + E E Q+E + + K ++ E K K ++Q K+
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQE--QEEKIWEQEKMEKKTQEQEK---KTWDQEKM 709
Query: 164 SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223
+R+ M EE++ + ++ E ++++ E Q + + + E+E + +
Sbjct: 710 R--EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 224 QQKQEQKNQLF--HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEE 269
Q+ EQK +L+ +Q +++ Q + MR + + R +EE
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Score = 32.7 bits (73), Expect = 0.65
Identities = 43/230 (18%), Positives = 95/230 (41%), Gaps = 26/230 (11%)
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
E+++ +SA+ + + +E L K + L++ R +E L ++ E
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALS-----LELYRNTITNEE----LKKKNAEL 230
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMV-TEKFPKELENK 288
+ +L A +Q +K + KR E KF L V T +E+ +
Sbjct: 231 QEKLPLAESEKSEIQLNVKEL-------------KRKLERAKFLLPQVQTNTLQEEMWRQ 277
Query: 289 KKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348
++EL +K + + + E ++ E ++ + EK + + + + R+Q
Sbjct: 278 EEELREQEKKIRKQ---EEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQE 334
Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
+ +KE + +E Q +++ E+E ++ + + + E L E+Q
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/260 (23%), Positives = 119/260 (45%), Gaps = 14/260 (5%)
Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
E P + L E T+ + +L ++L K E+L+ + S I ME+E +L
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244
K+VE L+ V+ Q+ Q +++ L EK + E + +E + +++
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
NQ S + + E+ +K +E+E K + + KE +K ++ F ++ + +
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
+ + ELE++++ + E N+L++KK+ + K+ Q+ S + R+ +
Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 361 ELQEAKE---KLASLEREAS 377
L K +L SLE+E S
Sbjct: 678 TLDSFKNLTFQLESLEKENS 697
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/286 (22%), Positives = 129/286 (45%), Gaps = 36/286 (12%)
Query: 125 LEVPSEFLQDETVADTNKQYEELMEA-FKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
LE +E L ++TV+ ++ + EA K + KE KI S E +S +E EK
Sbjct: 556 LEQENEHL-NQTVSSLRQRSQISAEARVKDIEKEN---KILHESIKETSSKLSKIEFEKR 611
Query: 184 QLIKRVEHLKKRVETAQN-----------HQWMLKIARQLRVEKEREEYLAQQKQE---Q 229
Q+ K +EH K++ E A+ ++ + K L++ E+ E L Q+ E +
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL-MKRLEEEIKF------NLYMVTEKFP 282
+L + + + QL+S+ + + E+L ++R E +K L + ++
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 283 KELENKKKELHFLQKVVSEPAMGHSDLLELESKINEI-NTEINQLIEKKMMRNEPIEGKL 341
E E KK L L+ + ++ LE+ + +I N + + +E + + +E +L
Sbjct: 732 SEKEQLKKGLELLKASFKK-----TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFD 387
Q + ++ + EEL+ + ++L LE+E +T + +
Sbjct: 787 ----QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Score = 49.7 bits (117), Expect = 5e-06
Identities = 57/285 (20%), Positives = 124/285 (43%), Gaps = 20/285 (7%)
Query: 101 VLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQ 160
+LH ++ T+ + + IK E+ + E + + L + + L K+
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREE 220
LKI+ + I A+E+E +L + LKK +++ +N + L+ + + + E
Sbjct: 651 LKITC-------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ---AAADAKPESLMKRLEEEIKF-NLYM 276
++ E + +LQ +L+S ++ + S K E+ + L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSDL------LELESKINEINTEINQLIEKK 330
++ K LEN K++ L+ + + M + L L++ SK E + N+ +E++
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 331 MMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
+ E + +L ++ + ++ E K L+E K+ +LE+E
Sbjct: 824 TSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Score = 47.0 bits (110), Expect = 3e-05
Identities = 64/326 (19%), Positives = 134/326 (41%), Gaps = 76/326 (23%)
Query: 125 LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177
L++ ++ LQ +T+ ++NK+ ++L + TL K E+LKIS ++ K+ +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 178 MEEEKDQLIK----------------------------RVEHLKKRVETAQNHQWMLK-- 207
+E+E QL K ++ +L+K +T + K
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 208 IARQLRVEKEREEYL-----------------------AQQKQEQKNQLFHAVQRLQRVQ 244
R +EKE +E + QQ +L H ++++ +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
+L Q+ D++ + L +LE +K K LE K++++ L+ + E +
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLK-----------KSLEIKEEKIAALEARLEE-ST 987
Query: 305 GHSDLLELESKINEINTEI---NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE 361
++ L E K + N E Q E+ + + PI G+ + + +++ +R+ +
Sbjct: 988 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
Query: 362 LQEAKEKLASLEREASVKRNQTREFD 387
L E + A+L+ E + Q ++ +
Sbjct: 1048 LIEVERNNATLQAEKQALKTQLKQLE 1073
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/200 (21%), Positives = 86/200 (43%), Gaps = 41/200 (20%)
Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253
KR E+ Q+ ++ +L K + L Q+ +E+ QL Q L++++ +LK ++Q
Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
+DA+ + + + ++ V +K E+ K+ LH D+
Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339
Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365
++++ E+ + L+E K M + +EG +R + K EL+ +
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387
Query: 366 KEKLASLEREASVKRNQTRE 385
K KL +E E + R + E
Sbjct: 388 KAKLHDMEMERDMDRKKIEE 407
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/260 (23%), Positives = 119/260 (45%), Gaps = 14/260 (5%)
Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
E P + L E T+ + +L ++L K E+L+ + S I ME+E +L
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 186 IKRVEHLKKR-VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQ 244
K+VE L+ V+ Q+ Q +++ L EK + E + +E + +++
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 245 NQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAM 304
NQ S + + E+ +K +E+E K + + KE +K ++ F ++ + +
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENK-----ILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 305 GHSD----LLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
+ + ELE++++ + E N+L++KK+ + K+ Q+ S + R+ +
Sbjct: 619 HYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 361 ELQEAKE---KLASLEREAS 377
L K +L SLE+E S
Sbjct: 678 TLDSFKNLTFQLESLEKENS 697
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/286 (22%), Positives = 129/286 (45%), Gaps = 36/286 (12%)
Query: 125 LEVPSEFLQDETVADTNKQYEELMEA-FKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
LE +E L ++TV+ ++ + EA K + KE KI S E +S +E EK
Sbjct: 556 LEQENEHL-NQTVSSLRQRSQISAEARVKDIEKEN---KILHESIKETSSKLSKIEFEKR 611
Query: 184 QLIKRVEHLKKRVETAQN-----------HQWMLKIARQLRVEKEREEYLAQQKQE---Q 229
Q+ K +EH K++ E A+ ++ + K L++ E+ E L Q+ E +
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL-MKRLEEEIKF------NLYMVTEKFP 282
+L + + + QL+S+ + + E+L ++R E +K L + ++
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 283 KELENKKKELHFLQKVVSEPAMGHSDLLELESKINEI-NTEINQLIEKKMMRNEPIEGKL 341
E E KK L L+ + ++ LE+ + +I N + + +E + + +E +L
Sbjct: 732 SEKEQLKKGLELLKASFKK-----TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFD 387
Q + ++ + EEL+ + ++L LE+E +T + +
Sbjct: 787 ----QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Score = 49.7 bits (117), Expect = 5e-06
Identities = 57/285 (20%), Positives = 124/285 (43%), Gaps = 20/285 (7%)
Query: 101 VLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQ 160
+LH ++ T+ + + IK E+ + E + + L + + L K+
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 161 LKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREE 220
LKI+ + I A+E+E +L + LKK +++ +N + L+ + + + E
Sbjct: 651 LKITC-------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 221 YLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ---AAADAKPESLMKRLEEEIKF-NLYM 276
++ E + +LQ +L+S ++ + S K E+ + L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSDL------LELESKINEINTEINQLIEKK 330
++ K LEN K++ L+ + + M + L L++ SK E + N+ +E++
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 331 MMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
+ E + +L ++ + ++ E K L+E K+ +LE+E
Sbjct: 824 TSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Score = 42.0 bits (97), Expect = 0.001
Identities = 63/314 (20%), Positives = 135/314 (42%), Gaps = 53/314 (16%)
Query: 125 LEVPSEFLQDETVADTNKQYEELMEAFK-------TLHKEYEQLKISGFSTAEIRKDISA 177
L++ ++ LQ +T+ ++NK+ ++L + TL K E+LKIS ++ K+ +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 178 MEEEKDQLIKRVEHLKK-------------------RVETAQNHQWMLKIARQLRVEKER 218
+E+E QL K + L+K V+ + +++++ + KE
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 219 EEYLAQQKQEQKNQLFHA---VQRLQRVQNQLKS--MRQAAADAKPESLMKRLE------ 267
L + ++E K + A ++ L ++ L S ++ + E L LE
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 268 ------EEIKFNLYMVTEK-----FPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI 316
E+ + Y + E K LE K++++ L+ + E + ++ L E K
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE-STNYNQQLRQELKT 998
Query: 317 NEINTEI---NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLE 373
+ N E Q E+ + + PI G+ + + +++ +R+ + L E + A+L+
Sbjct: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
Query: 374 REASVKRNQTREFD 387
E + Q ++ +
Sbjct: 1059 AEKQALKTQLKQLE 1072
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/200 (21%), Positives = 86/200 (43%), Gaps = 41/200 (20%)
Query: 194 KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253
KR E+ Q+ ++ +L K + L Q+ +E+ QL Q L++++ +LK ++Q
Sbjct: 241 KRTESRQH------LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
Query: 254 ----AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
+DA+ + + + ++ V +K E+ K+ LH D+
Sbjct: 295 NMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRYKERLH--------------DI 339
Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQ----EA 365
++++ E+ + L+E K M + +EG +R + K EL+ +
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLEG------------TRARSDKLHELEKENLQL 387
Query: 366 KEKLASLEREASVKRNQTRE 385
K KL +E E + R + E
Sbjct: 388 KAKLHDMEMERDMDRKKIEE 407
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/269 (26%), Positives = 121/269 (44%), Gaps = 25/269 (9%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRV-ETAQ 200
++ EEL E K L K E+L+ E+R I+ E L+ VE+L+KRV E
Sbjct: 340 QRIEELEETNKNLQKAEEELQ-------ELRDKIAKGECGNSSLMAEVENLRKRVLEMEG 392
Query: 201 NHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPE 260
+ + K Q R +++ Q+++ +L V++LQ+ ++L+ + +A + +K E
Sbjct: 393 KDEEITKTESQCRELRKK----LQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELE---NKKKELHFLQKVVSEPAMG-HSDLLELESKI 316
L E + NL T+ ELE ++ KEL + + + + DL +L+S
Sbjct: 449 CTQLHLNLEKEKNL---TKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFT 505
Query: 317 NEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREA 376
+ E ++EK ++G + + K E+L E +KL L+ E
Sbjct: 506 VMLVDERKNMMEKIKQEERKVDG----LNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEM 561
Query: 377 SVK-RNQTREFDG-TEVLKGDERQDLTLS 403
K N TRE D LK +E + LS
Sbjct: 562 EEKVYNLTRERDELIGKLKSEEEKSSELS 590
Score = 40.4 bits (93), Expect = 0.003
Identities = 60/271 (22%), Positives = 113/271 (41%), Gaps = 35/271 (12%)
Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191
L+ E + + E+L EAF E QL ++ + KD+ E +K +E
Sbjct: 423 LEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELEC 482
Query: 192 LKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMR 251
+ R+E A+ L + L + + + E+KN + Q ++V K+ +
Sbjct: 483 SESRLEKAE-----LSLKDDL---TKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFK 534
Query: 252 QAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE 311
K + ++L EE K L + +E K ++ + K+ SE
Sbjct: 535 --VEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSE---------- 582
Query: 312 LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEEL---QEAKEK 368
E K +E++ ++ L++K++ E +E + I+R + K EL ++ K K
Sbjct: 583 -EEKSSELSCSVD-LLKKRLDGIEEVERE----------ITRGRSRKGSELTCPEDNKIK 630
Query: 369 LASLEREASVKRNQTREFDGTEVLKGDERQD 399
+LE E KR Q E +++K ++ D
Sbjct: 631 ELTLEIERLKKRLQQLEVVEGDLMKTEDEYD 661
Score = 31.2 bits (69), Expect = 1.9
Identities = 37/169 (21%), Positives = 78/169 (46%), Gaps = 26/169 (15%)
Query: 174 DISAMEEEK-DQLIKRVEHLKKRVETAQNHQWML--------KIARQLRVEKEREEYLAQ 224
+++ E+ K +L +E LKKR++ + + L ++ ++ R E+++ +L+Q
Sbjct: 620 ELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQ 679
Query: 225 QKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEE----EIKFNLYMVTEK 280
Q +E K+Q+ +N+ + + RLEE ++K + + EK
Sbjct: 680 QLEEIKHQI---------AKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEK 730
Query: 281 FPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEK 329
EL NK+ +L LQ + ++ +E E+K + E+ L ++
Sbjct: 731 I-HELMNKEDQLSQLQ---VDYSVLQQRFMEEENKNKNMGQEVLNLTKE 775
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 57.8 bits (138), Expect = 2e-08
Identities = 61/275 (22%), Positives = 126/275 (45%), Gaps = 17/275 (6%)
Query: 111 ELKKRAYLARFLIKLEVPSEFLQ-DETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTA 169
ELK + + + L+ LQ E +TN+Q E ++ E+L S T
Sbjct: 1182 ELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK---------EELSASSARTQ 1232
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
++ D+ EE+ L +++ KK+++ Q +++ +L K E L ++K +
Sbjct: 1233 NLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINE--LEKKKNQC 1290
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRL--EEEIKFNLYMVTEKFPKELEN 287
+L + +Q+++ QL + + A + E K L +E+I ++ M E+ + +
Sbjct: 1291 SQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEE---QEQT 1347
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
+ ++ L+ + E ++L + + K N++ T+ NQ K+ N + GKL+ + +
Sbjct: 1348 QVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDE 1407
Query: 348 ASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
+K A ++ E K L + +EA RN+
Sbjct: 1408 LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNK 1442
Score = 45.8 bits (107), Expect = 7e-05
Identities = 54/252 (21%), Positives = 111/252 (44%), Gaps = 13/252 (5%)
Query: 147 LMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLK-----KRVETAQN 201
+++ + L + E L+ S +T ++ ++EE QL ++ +K K E N
Sbjct: 1154 ILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETN 1213
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES 261
Q K+ +L R + L Q ++ ++L + Q+K +++ + + E
Sbjct: 1214 RQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDED 1273
Query: 262 LMKRLEEEIKFN-LYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
+ R IK N L + +EL+ K++ + L++ ++ + + + + E ++N
Sbjct: 1274 KLLR----IKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEA-IQQYERACKDLN 1328
Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
+ ++IE M E E Q + E A EL++ KEK LE + + +
Sbjct: 1329 VK-EKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRS 1387
Query: 381 NQTREFDGTEVL 392
N+ E + T+VL
Sbjct: 1388 NKEHE-NNTDVL 1398
Score = 38.1 bits (87), Expect = 0.016
Identities = 50/238 (21%), Positives = 103/238 (43%), Gaps = 17/238 (7%)
Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
E + + EEL A +T + E + L T E K + EEK +L+ +E LKK
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFIS-HEEKRKLLDLIEDLKK 585
Query: 195 RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL-QRVQNQLKSMRQ- 252
++ + + L+ + V +E +Y AQ++ + K L + L + + +L +
Sbjct: 586 KLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDL 645
Query: 253 -AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLE 311
D + E+ +++ TE+ LE K ++ +E A +L++
Sbjct: 646 VGKCDTREEAAKDICATKVE------TEEATACLELK------FNQIKAELAKTKGELIK 693
Query: 312 LESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
+ ++ + E + LI++ N+ I + ++ +II +K++ E Q K +
Sbjct: 694 TKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDT-INEFQNLKSHM 750
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 641 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 700
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 701 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 760
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 761 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 816
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 817 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 875
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 876 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 925
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 797 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 855
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 856 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 903
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 904 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 957
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 958 QGQMDEDVQKVLKQILTMCKNQSQKK 983
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 630 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 689
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 690 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 749
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 750 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 805
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 806 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 864
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 865 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 914
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 786 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 844
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 845 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 892
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 893 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 946
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 947 QGQMDEDVQKVLKQILTMCKNQSQKK 972
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 609 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 668
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 669 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 728
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 729 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 784
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 785 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 843
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 844 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 893
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 765 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 823
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 824 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 871
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 872 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 925
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 926 QGQMDEDVQKVLKQILTMCKNQSQKK 951
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 638 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 697
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 698 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 757
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 758 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 813
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 814 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 872
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 873 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 922
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 794 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 852
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 853 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 900
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 954
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 955 QGQMDEDVQKVLKQILTMCKNQSQKK 980
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 638 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 697
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 698 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 757
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 758 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 813
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 814 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 872
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 873 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 922
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 794 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 852
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 853 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 900
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 954
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 955 QGQMDEDVQKVLKQILTMCKNQSQKK 980
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/290 (19%), Positives = 129/290 (44%), Gaps = 41/290 (14%)
Query: 137 VADTNKQYEELMEAFKT---------------------LHK-EYEQL-KISGFSTAEIRK 173
+ + NKQ EL + +K +HK E+E+L +++ S A+
Sbjct: 638 IDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 697
Query: 174 DISAMEEEKDQLIKRVEHLKKRVETAQNHQWM----LKIARQLRVE-KEREEYLAQQKQE 228
+S M+ + +++ + LK+ V+ + + L++ LR KE EE ++ K+
Sbjct: 698 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 757
Query: 229 QKNQLFHAVQRLQRVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFPKELEN 287
L + +++ QL + A DA P S ++L+ ++ + ++ K + ++
Sbjct: 758 ----LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKE 813
Query: 288 KKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQ 347
K+K + ++ SE + + +++ + E+N+L++K E + ++ Y +
Sbjct: 814 KEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL-AEMKRYAES 872
Query: 348 ASIISRKKEAKAEE-------LQEAKEKLASLEREASVKRNQTREFDGTE 390
+S + K+ K E L+EA L+ L S + Q+++ + +
Sbjct: 873 SSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQ 922
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/206 (21%), Positives = 95/206 (46%), Gaps = 20/206 (9%)
Query: 176 SAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI-ARQLRVEKEREEYLAQQKQEQKNQLF 234
S++E E L +++ K E + ++ Q++ EKE + L + K+++ N+L
Sbjct: 794 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL- 852
Query: 235 HAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHF 294
+Q+ Q+ Q +L M++ A + +LEE+ + + KE+ K+ L+
Sbjct: 853 --LQKFQQAQEELAEMKRYAESSS------KLEEDKDKKI----NEMSKEVTKLKEALNS 900
Query: 295 LQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRK 354
L ++ + +LE+ ++ NQL E K E I S+YR ++
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVI----SVYRMH--LLYAV 954
Query: 355 KEAKAEELQEAKEKLASLEREASVKR 380
+ E++Q+ +++ ++ + S K+
Sbjct: 955 QGQMDEDVQKVLKQILTMCKNQSQKK 980
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/267 (20%), Positives = 127/267 (47%), Gaps = 10/267 (3%)
Query: 126 EVPSEFLQDETVA--DTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKD 183
E E+ + ETV + K EE + + L +E EQL+ E+R++ EE++
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR--KLERQELRRERQE-EEQQQ 297
Query: 184 QLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRV 243
Q ++R + L+++ E + Q + +Q R E++ E Q ++EQ+ + ++R Q
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 244 QNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE-NKKKELHFLQKVVSEP 302
+ + + +R+ + + E ++R ++ + ++ +E + ++++L Q++ E
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 303 AMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS----IISRKKEAK 358
+ L E + + Q ++ ++ E E + L R++ + RK++ K
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 359 AEELQEAKEKLASLEREASVKRNQTRE 385
++ +E +E+ LE E ++ + RE
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERRE 504
Score = 53.5 bits (127), Expect = 4e-07
Identities = 42/219 (19%), Positives = 109/219 (49%), Gaps = 17/219 (7%)
Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
+E+++ ++++E + R E + Q ++ R+ ++ +++EE +Q++E++ Q Q+
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
+R + QL+ + + + E ++R +EE + + E +E E ++++L Q++
Sbjct: 332 EERREQQLRREQ----EERREQQLRREQEEERREQQLRRE---QEEERREQQLRREQQLR 384
Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
E + L E ++ E+++ R + + + L R+Q + ++E +
Sbjct: 385 REQQLRREQQLRREQQLRR---------EQQLRREQQLRREQQLRREQ-QLRREQEEERH 434
Query: 360 EELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
E+ E + + L+RE +R+ + + TE + + R+
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Score = 52.0 bits (123), Expect = 1e-06
Identities = 68/305 (22%), Positives = 140/305 (45%), Gaps = 27/305 (8%)
Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
Q+ L++ L R K E Q+E ++ ++ + L +E E+ +
Sbjct: 295 QQQQRLRREQQLRR---KQEEERREQQEERREQQERREQQEERREQQLRREQEERR---- 347
Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWM-----LKIARQLRVEKE--RE 219
++R++ EE ++Q ++R + ++R + + Q + L+ +QLR E++ RE
Sbjct: 348 -EQQLRREQE--EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 220 EYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTE 279
+ L +++Q ++ Q Q+L+R Q + + Q + E +KR +EE + L E
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERH-EQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 280 KFPKELENKKKELHFLQKVVSEPAMGHSDLLEL----ESKINEINTEINQLIEKKMMRNE 335
E E +K++L Q+ + E E + ++ E + E+++ R E
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523
Query: 336 PIEGKLSLYRQQASIISRKKEAKAEEL--QEAKEKLASLEREASVKRNQTREFDGTEVLK 393
E +L + + R++E + E+L +E +++L RE +KR Q D ++LK
Sbjct: 524 E-EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD--QLLK 580
Query: 394 GDERQ 398
+E +
Sbjct: 581 REEER 585
Score = 50.8 bits (120), Expect = 2e-06
Identities = 65/291 (22%), Positives = 133/291 (45%), Gaps = 29/291 (9%)
Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNK--QYEELMEAFKTLHKEYEQLKIS 164
+R LK+ R +K E +E + E K Q EE E + L +E E+ +
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE-ERREQQ 500
Query: 165 GFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE-REEYLA 223
++R++ EE ++Q +KR E ++ Q L+ +QLR E+E R E L
Sbjct: 501 ERREQQLRRE---QEERREQRLKRQEEEERL-------QQRLRSEQQLRREQEERREQLL 550
Query: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
++++E++ + QRL+R Q + + + + + +KR E+E + + E+ +
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR-EQEERLEQRLKREEVER 609
Query: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELES----KINEINTEINQLIEKKMMRNEPIEG 339
+ +++E ++ E LL+ E + ++ E + E+++ R E E
Sbjct: 610 LEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 340 KLSLYRQQASIISRKKEAKAEELQEAKEKLAS--------LEREASVKRNQ 382
+++ R++E EE ++A+E++ S LE EA ++++
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Score = 49.7 bits (117), Expect = 5e-06
Identities = 66/307 (21%), Positives = 141/307 (45%), Gaps = 27/307 (8%)
Query: 107 QRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
QR EL++ R L + E+ E ++E +Q + L + K+ E+ +
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEE------QQQQRLRREQQLRRKQEEERREQQE 319
Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLA 223
E ++ EE ++Q ++R E ++R + + Q + +QLR E+E RE+ L
Sbjct: 320 ERREQQERREQQEERREQQLRR-EQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 224 QQKQEQKNQLFHAVQRLQRVQ-----NQLKSMRQAAAD--AKPESLMKRLEEEIKFNLYM 276
+++Q ++ Q Q+L+R Q QL+ +Q + + E ++R +EE +
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP 336
E+ + L+ +++E K E ++ E E + ++ + + ++ ++ E
Sbjct: 439 EQERREQRLKREQEERRDWLKREEE-----TERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 337 IEGKLSLYRQQASIISRKKEAKAEEL--QEAKEKLAS-LEREASVKRNQTREFDGTEVLK 393
E + R++ + ++E + + L QE +E+L L E ++R Q + ++LK
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE--QLLK 551
Query: 394 GDERQDL 400
+E + L
Sbjct: 552 REEEKRL 558
Score = 49.7 bits (117), Expect = 5e-06
Identities = 53/276 (19%), Positives = 125/276 (45%), Gaps = 10/276 (3%)
Query: 130 EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189
+FL++E ++ ++L E L ++ E+ + + E R+D + +++ +R
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR-----SQEQRRDQKWRWQLEEERKRRR 886
Query: 190 EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
L + + + ++ ++ E +REE +++QEQ+ Q + ++LQ+ + QL
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ-YREEEQLQQEEEQLLR 945
Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
+ + R +++++ + + P++ +++E + ++ E +
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE---EELQQEEEQ 1002
Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE-LQEAKEK 368
L E + E + KK + E L R++ + R+++ + EE LQ+ +E+
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 369 LASLEREASVKRNQTREFDGTEVLKGDERQDLTLSP 404
L ERE ++ R++ E L+ +E Q L P
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/266 (21%), Positives = 115/266 (43%), Gaps = 36/266 (13%)
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETA----------QNHQWMLKIARQLRVEKERE 219
++RK+ ++EE+++L + ++R E Q + +L+ R+ R +ERE
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 220 EYLAQQK--QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI------- 270
+ K Q+++ QL +R Q + K R+ + E + R E E
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 271 -----KFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKI--NEINTEI 323
K L E+ +E E +K+ L ++ E +L + E ++ E T
Sbjct: 1018 RQYRKKDELQQEEEQLLRE-EREKRRLQERERQYRE----EEELQQEEEQLLGEERETRR 1072
Query: 324 NQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA-----EELQEAKEKLASLEREASV 378
Q +E++ + E ++ + ++ R++E + EELQ+ +E+L ERE
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 379 KRNQTREFDGTEVLKGDERQDLTLSP 404
++ R++ E ++ +E Q L P
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEP 1158
Score = 46.6 bits (109), Expect = 4e-05
Identities = 53/270 (19%), Positives = 123/270 (45%), Gaps = 12/270 (4%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEE---KDQLIKRVEHLKKRVET 198
+Q EE E +E E+ + ++R++ E+ ++Q ++R + L++ +
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 199 AQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK 258
+ Q L+ +QLR E+E E + + +QE++ Q Q +R + + + +
Sbjct: 414 RREQQ--LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 259 PESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE 318
+ +KR +EE + ++ E+ + + +++E L++ E E E ++ +
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQ-LRREQEERREQRLKRQEEEERLQQ 530
Query: 319 INTEINQLIEKKMMRNEPI----EGKLSLYRQQASIISRKKEAKAEEL--QEAKEKLASL 372
QL ++ R E + E K ++ + R++E + ++L +E + + L
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 373 EREASVKRNQTREFDGTEVLKGDERQDLTL 402
+RE + Q + + E L+ +ER++ L
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRL 620
Score = 46.6 bits (109), Expect = 4e-05
Identities = 56/268 (20%), Positives = 115/268 (42%), Gaps = 19/268 (7%)
Query: 130 EFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRV 189
E L+ E + ++ + E + L +E E+ + + + R++ ++E ++Q ++R
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 190 EHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
E +K E HQ Q R E E+ L +Q++E+K R Q + QL+
Sbjct: 1357 ERDRKFREEELRHQ------EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
R + E + R E + KF + +++ +++E FL++ H
Sbjct: 1411 DRDRKF-REEEQQLSRQERDRKF------REEEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
E E + E Q + ++ + +E + L RQ+ R++E ++ QE + K
Sbjct: 1464 REEEQLLQE---REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS---QEPERKF 1517
Query: 370 ASLEREASVKRNQTREFDGTEVLKGDER 397
E++ ++ Q + + L+ ER
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/269 (24%), Positives = 115/269 (42%), Gaps = 39/269 (14%)
Query: 148 MEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLK 207
+E K +E E+ + ++ + +E+D+ + E L + E Q H
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH----- 1637
Query: 208 IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLE 267
RQ R K EE ++QE++ QL H R R + QL + E ++R E
Sbjct: 1638 --RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE-------EQQLRRQE 1688
Query: 268 EEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE-----INTE 322
+ KF + ++L +++E FLQ+ E + ELE K E TE
Sbjct: 1689 RDRKF------REEEQQLRRQERERKFLQE---EQQLRRQ---ELERKFREEEQLRQETE 1736
Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
QL ++ R E +L R++ + ++++ K E ++ ++ ERE R+Q
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ-----EREEQQLRSQ 1791
Query: 383 --TREFDGTEVLKGDERQDLTLSPRLECG 409
R+F E L+ ER++ L P+ G
Sbjct: 1792 ESDRKFREEEQLR-QEREEQQLRPQQRDG 1819
Score = 42.4 bits (98), Expect = 8e-04
Identities = 48/224 (21%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQ 238
EEEK+Q ++ +K ++ + + + + R ++++E E+ L + ++ +++Q Q
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE-EDGLQEDQERRRSQEQRRDQ 872
Query: 239 RLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKV 298
+ + + + R+ AKP +L ++L +E + L E+ +E K++ ++
Sbjct: 873 KWRWQLEEERKRRRHTLYAKP-ALQEQLRKEQQL-LQEEEEELQREEREKRRRQEQERQY 930
Query: 299 VSEPAMGHSD---LLELESKINEINTEINQLIEKKM-MRNEPIEGKLSLYRQQASIISRK 354
E + + L E K E +KK+ + E + G+ R++ K
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE--REK 988
Query: 355 KEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
K + EELQ+ +E+L ERE ++ R++ + L+ +E Q
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Score = 42.0 bits (97), Expect = 0.001
Identities = 47/222 (21%), Positives = 108/222 (48%), Gaps = 16/222 (7%)
Query: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQL-FHAVQR 239
+++Q ++R E ++R Q+ + QLR E+E E+ L++Q++++K +L V+R
Sbjct: 1535 QEEQQLRRQERGQQR---RQDRDRKFREEEQLRQERE-EQQLSRQERDRKFRLEEQKVRR 1590
Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
++ + ++ +Q + L + + + + + ++ E+ ++L ++++ FL++
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE-- 1648
Query: 300 SEPAMGHSDL-LELESKINEINTEINQLI---EKKMMRNEPIEGKLSLYRQQASIISRKK 355
EP + + +L + E QL+ E++ +R + + K QQ R++
Sbjct: 1649 -EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 356 EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDER 397
+ EE Q +++L RE R +T + E L+ ER
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQ----EQLRRQER 1745
Score = 40.4 bits (93), Expect = 0.003
Identities = 60/278 (21%), Positives = 122/278 (43%), Gaps = 50/278 (17%)
Query: 122 LIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEE 181
L + E +FL++E ++ ++L +E EQL G R++ E
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 182 KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQ 241
++Q ++R E +K ++ Q ++ RQ K REE Q +QE + + +R +
Sbjct: 1696 EEQQLRRQERERKFLQEEQ------QLRRQELERKFREE--EQLRQETEQEQLRRQERYR 1747
Query: 242 RV--QNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVV 299
++ + QL+ R+ E ++R E + KF + ++L +++E Q++
Sbjct: 1748 KILEEEQLRPERE-------EQQLRRQERDRKF-------REEEQLRQEREE----QQLR 1789
Query: 300 SEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
S+ E + K E ++ Q E++ +R + +GK +Q + +++ +
Sbjct: 1790 SQ---------ESDRKFRE-EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 360 EELQE--AKEKLASLER----------EASVKRNQTRE 385
E ++ A+E+ A+ E+ E KR Q RE
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/185 (23%), Positives = 86/185 (46%), Gaps = 24/185 (12%)
Query: 210 RQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK--------PES 261
R ++E+E + Q++QEQ+ +L ++ ++ Q +L+ + D + E
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK-QERLEQRDRQRRDEELWRQRQEWQER 183
Query: 262 LMKRLEEE-IKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
+R EEE ++ TE+FP E + +++EL L++ E E + + E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE---------EKQQQRRERQ 234
Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
+ Q E+K R + ++ R++ + ++ + ELQE +E+L LER+ +
Sbjct: 235 DRVFQEEEEKEWRK-----RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 381 NQTRE 385
Q E
Sbjct: 290 RQEEE 294
Score = 39.7 bits (91), Expect = 0.005
Identities = 51/225 (22%), Positives = 95/225 (42%), Gaps = 23/225 (10%)
Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
+E++Q +++ K R E Q ++RQ R K REE ++QE++ + Q+
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQ-------LSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 240 LQ-------RVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF-PKELENKKKE 291
L+ R + QL R+ + E K LEEE + KF +EL +++ E
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 292 LHFLQKVVS-EPAMGHSDLLELESKI--NEINTEINQLIEKKMMRNEPIEGKLSLYRQQA 348
FL++ L+ E ++ E + Q ++K E + ++
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR-----QEREE 1569
Query: 349 SIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLK 393
+SR++ + L+E K + ER+ Q R +G + L+
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Score = 29.6 bits (65), Expect = 5.5
Identities = 49/257 (19%), Positives = 113/257 (43%), Gaps = 16/257 (6%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
++ EE+ + + L +E + + + R++ +++E++QL+ R E K+R E +
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLL-REEQEKRRQERERQ 1198
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPES 261
++ ++ RQ R ++ R+E Q+ + K Q + R R+ + E
Sbjct: 1199 YREEEELQRQKRKQRYRDE---DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 262 LMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINT 321
R + + +++ E+ ++ E +++ + E + LE E +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE-----EEQLEREEQKEAKRR 1310
Query: 322 EINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381
+ EK+++R E E + RQ+ R++E +E +E + L ER+ +
Sbjct: 1311 DRKSQEEKQLLREEREEKR---RRQETDRKFREEEQLLQEREE--QPLRRQERDRKFREE 1365
Query: 382 QTR-EFDGTEVLKGDER 397
+ R + G + L+ ++R
Sbjct: 1366 ELRHQEQGRKFLEEEQR 1382
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 56.2 bits (134), Expect = 6e-08
Identities = 57/241 (23%), Positives = 110/241 (45%), Gaps = 35/241 (14%)
Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKI----------ARQLRVEKER 218
AE K I +++E+ +L+ HLK+R++ + + KI +R L ++ E
Sbjct: 1086 AESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAEN 1145
Query: 219 EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEE-EIKFNLYMV 277
E QQ + + LQ+ + QLK Q + K LE + +++ ++
Sbjct: 1146 EVLQLQQTLFSMKAIQKQCETLQKNKKQLK---QEVVNLKSYMERNMLERGKAEWHKLLI 1202
Query: 278 TEKFPKELENKKKE-LHFLQKVVSEPAMGHSDLLEL------------ESKINEINTEIN 324
E+ KE+E K E + LQK + A+ H L++L E I ++ +EI+
Sbjct: 1203 EERARKEIEEKLNEAILTLQK---QAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEIS 1259
Query: 325 QLIEKKMMRNE-PIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQT 383
++ + N+ +E LY ++ + +E+ + EL E +A + + +V++ QT
Sbjct: 1260 RIKTSQADFNKTELERYKELYLEEVKV----RESLSNELSRTNEMIAEVSTQLTVEKEQT 1315
Query: 384 R 384
R
Sbjct: 1316 R 1316
Score = 47.0 bits (110), Expect = 3e-05
Identities = 56/237 (23%), Positives = 104/237 (43%), Gaps = 14/237 (5%)
Query: 160 QLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWML-KIARQLRVEKER 218
Q ++S +++ ++ +E EK+ R+ LK+ E +N + K + QLR+++E
Sbjct: 674 QNELSETKKTKLQLELQKIEWEKELYDLRLA-LKQENEEKRNADMLYNKDSEQLRIKEEE 732
Query: 219 EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVT 278
+ + KQ+ K L V+ L+ V+N L + Q DA+ + L + + I + + +
Sbjct: 733 CGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQ-KQLSEEQDARILQDQILTS 791
Query: 279 EKFPKELENKKKELHFLQKVVSEPAMGHSDLL---ELESKINEINTEINQLIEKKMMRNE 335
++ E+ KK + E + H D + E+ EI+T NQ +K+ E
Sbjct: 792 KQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFE 851
Query: 336 PIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASV--------KRNQTR 384
IE II +E E + + +L +L E + K+NQ R
Sbjct: 852 DIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQER 908
Score = 29.6 bits (65), Expect = 5.5
Identities = 32/141 (22%), Positives = 58/141 (41%), Gaps = 14/141 (9%)
Query: 147 LMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWML 206
L+ TLH + + E +D EE+ + +K E+ K+ +T+Q +
Sbjct: 198 LLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGCEN-KQPQKTSQEPEMAK 256
Query: 207 KIARQ--------LRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK 258
R+ V+K E ++ Q K E KNQL + L++ ++ + A +
Sbjct: 257 DCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPE 316
Query: 259 PESLMKRLE-----EEIKFNL 274
E L+ ++I FNL
Sbjct: 317 EEPLLDNSTRGTDVKDIPFNL 337
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 55.8 bits (133), Expect = 7e-08
Identities = 60/283 (21%), Positives = 134/283 (47%), Gaps = 24/283 (8%)
Query: 111 ELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE 170
ELK++ A+FL+ +V + LQ+E +Q EEL E K + K+ E++
Sbjct: 212 ELKRKLERAKFLLP-QVQTNTLQEEMW----RQEEELREQEKKIRKQEEKM---WRQEER 263
Query: 171 IRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVE----KEREEYLAQQK 226
+R+ M E+++++ ++ + L+++ + + + L+ ++LR + +E+EE + +Q+
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 227 Q---EQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
+ EQ+ +++ +RL + Q++ Q D E M +E ++ + E+
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRD--QEERMWEQDERLREKEERMREQEKM 381
Query: 284 -ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLS 342
E E K +E +++ + + E E K+ + + + EK+ + E K
Sbjct: 382 WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441
Query: 343 LYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTRE 385
L+ Q+ K + + E++ E +EK+ E ++ R+
Sbjct: 442 LWEQE------KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 478
Score = 47.4 bits (111), Expect = 3e-05
Identities = 52/232 (22%), Positives = 110/232 (47%), Gaps = 31/232 (13%)
Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKE---REEYLAQQ 225
AE+++ + E EK ++ V+ LK+++E A +++L + +++E +EE L +Q
Sbjct: 190 AELQEKLRLAESEKSEIQLNVKELKRKLERA---KFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKEL 285
+++ + Q ++ +R++ Q MR+ E M+R E+ ++ + KEL
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMRE------QEEKMRRQEKRLR--------EQEKEL 292
Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345
++KEL +K+ + + E E K+ E ++ + EK + E + + R
Sbjct: 293 REQEKELREQKKLREQ----EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 346 QQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDER 397
+Q +K + E + E E+L E R Q + ++ E ++ +ER
Sbjct: 349 EQ----EQKMRDQEERMWEQDERLREKEER---MREQEKMWEQEEKMQEEER 393
Score = 41.2 bits (95), Expect = 0.002
Identities = 50/261 (19%), Positives = 115/261 (44%), Gaps = 14/261 (5%)
Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192
Q E + + K E+ + ++ K +Q ++ G R++ M E++DQ+ ++ E +
Sbjct: 438 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE--KMREQEDQMWEQEEKM 495
Query: 193 K---KRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKS 249
+ +++ + W + + E+ RE+ Q++E+ + ++ ++ +Q +
Sbjct: 496 RDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEK 555
Query: 250 MRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDL 309
MR+ + E M+ EE ++ + E+ K E ++K +K+ + +
Sbjct: 556 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQ----EEKM 611
Query: 310 LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKL 369
E E K+ E E +++MM + E K+ ++ K + E+++E +EK+
Sbjct: 612 WEQEEKMWEQEEEDKMQEQEEMMWEQ--EEKMQEQEEKMWEQEEKMREQEEKMREQEEKM 669
Query: 370 ASLEREASVKRNQTREFDGTE 390
E + R Q + G E
Sbjct: 670 QGQEEK---MREQEEKMQGQE 687
Score = 38.1 bits (87), Expect = 0.016
Identities = 53/275 (19%), Positives = 125/275 (45%), Gaps = 30/275 (10%)
Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHL 192
Q+E + + +++ E E + K +EQ + IR+ M EE++ + ++ E +
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEEKMQ-EEERIREREKKMREEEETMREQEEKM 415
Query: 193 KKRVETA---QNHQWMLKIARQLRVEKEREEYLAQQK-QEQKNQLFHAVQRL---QRVQN 245
+K+ E + +W +Q R+ +++E+ Q+K QEQ+ +++ +++ + +
Sbjct: 416 QKQEENMWEQEEKEW-----QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305
Q K M + + E M EE+++ + ++ + E ++ +++ + M
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 306 HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEE--LQ 363
E K+ E Q EKK E R++ + R+K+ + EE ++
Sbjct: 531 QQ-----EEKMREEKKTQEQ--EKKTWDQE------EKMREEERMREREKKMREEEEMMR 577
Query: 364 EAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
E +EK+ E+E ++ + + ++ E ++ E +
Sbjct: 578 EQEEKMQ--EQEEKMREQEEKMWEQEEKMQEQEEK 610
Score = 31.2 bits (69), Expect = 1.9
Identities = 32/167 (19%), Positives = 73/167 (43%), Gaps = 9/167 (5%)
Query: 238 QRLQRVQNQLKSMRQAAADAKPE-----SLMKRLEEEIKFNLYMV-TEKFPKELENKKKE 291
+ L++ +L+ + A K E +KR E KF L V T +E+ +++E
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 242
Query: 292 LHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASII 351
L +K + + + E ++ E ++ + EK + + + + R+Q +
Sbjct: 243 LREQEKKIRKQ---EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 352 SRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
+K+ + +E Q +++ E+E ++ + + + E L E+Q
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Score = 31.2 bits (69), Expect = 1.9
Identities = 35/208 (16%), Positives = 93/208 (44%), Gaps = 25/208 (12%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
++ E + E K + +E E + R+ M+E+++++ ++ E + ++ E Q
Sbjct: 557 REEERMREREKKMREEEEMM----------REQEEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 202 HQWMLKIARQLRVEKEREEYLAQQK----------QEQKNQLFHAVQRLQRVQNQLKSMR 251
+ + + E+E E+ + +Q+ QEQ+ +++ ++++ + +++
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Query: 252 QAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKV--VSEPAMGHSDL 309
+ E M+ EE+++ + E+ K ++K +K+ E G ++
Sbjct: 667 EKMQG--QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEM 724
Query: 310 LELESKINEINTEINQ-LIEKKMMRNEP 336
E E +I + ++ + L E + +EP
Sbjct: 725 REKEERIRDQKEKMQERLPEHEERCSEP 752
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 55.5 bits (132), Expect = 9e-08
Identities = 62/283 (21%), Positives = 126/283 (44%), Gaps = 34/283 (12%)
Query: 109 TNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEEL--MEAFKTLHKEYEQLKISGF 166
T E KKR R ++LE + L ++ K+ E L +E + KE E+ +
Sbjct: 349 TFEDKKRENFERGNLELEKRRQALLEQQ----RKEQERLAQLERAEQERKERERQEQERK 404
Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQK 226
E+ K + E + Q R E +K +E + + L+ RQL E+ R + L Q+
Sbjct: 405 RQLELEKQLEKQRELERQ---REEERRKEIERREAAKRELERQRQLEWERNRRQELLNQR 461
Query: 227 QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE 286
+++ + + + ++ +L+++ K L +L++ + T++ E
Sbjct: 462 NKEQEDIVVLKAKKKTLEFELEALND-----KKHQLEGKLQD---IRCRLTTQRQEIEST 513
Query: 287 NKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG--KLSLY 344
NK +EL +++ L+ ++ E + +LI +K + N+ ++ + SL+
Sbjct: 514 NKSRELRI------------AEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLH 561
Query: 345 RQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFD 387
R + R EAK Q +++L +E+E R++ +E D
Sbjct: 562 RDSLVTLKRALEAKELARQHLRDQLDEVEKET---RSKLQEID 601
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 55.5 bits (132), Expect = 9e-08
Identities = 62/283 (21%), Positives = 126/283 (44%), Gaps = 34/283 (12%)
Query: 109 TNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEEL--MEAFKTLHKEYEQLKISGF 166
T E KKR R ++LE + L ++ K+ E L +E + KE E+ +
Sbjct: 349 TFEDKKRENFERGNLELEKRRQALLEQQ----RKEQERLAQLERAEQERKERERQEQERK 404
Query: 167 STAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQK 226
E+ K + E + Q R E +K +E + + L+ RQL E+ R + L Q+
Sbjct: 405 RQLELEKQLEKQRELERQ---REEERRKEIERREAAKRELERQRQLEWERNRRQELLNQR 461
Query: 227 QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE 286
+++ + + + ++ +L+++ K L +L++ + T++ E
Sbjct: 462 NKEQEDIVVLKAKKKTLEFELEALND-----KKHQLEGKLQD---IRCRLTTQRQEIEST 513
Query: 287 NKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEG--KLSLY 344
NK +EL +++ L+ ++ E + +LI +K + N+ ++ + SL+
Sbjct: 514 NKSRELRI------------AEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLH 561
Query: 345 RQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFD 387
R + R EAK Q +++L +E+E R++ +E D
Sbjct: 562 RDSLVTLKRALEAKELARQHLRDQLDEVEKET---RSKLQEID 601
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 55.5 bits (132), Expect = 9e-08
Identities = 75/323 (23%), Positives = 143/323 (44%), Gaps = 37/323 (11%)
Query: 112 LKKRAYLARFLIKLEVPSEFLQ------DETVADTNKQYEELMEAFKTLH-----KEYEQ 160
LK + +L L LE S+ L + +A NK+ E L++ ++L +YE+
Sbjct: 2027 LKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEK 2086
Query: 161 LKISGFSTA------EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRV 214
L +S A E +S+ +EE QL + +E L+ R+E + Q L IA +L+
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ--LHIAEKLK- 2143
Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIK--- 271
E+ERE + K E + ++ +L + + A+ E+L ++EE +
Sbjct: 2144 ERERENDSLKDKVENLEREL----QMSEENQELVILDAENSKAEVETLKTQIEEMARSLK 2199
Query: 272 -FNLYMVT-----EKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQ 325
F L +VT E K+++ K+ +L L K++S S L E E +I E
Sbjct: 2200 VFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS---FKSLLEEKEQAEIQIKEESKT 2256
Query: 326 LIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLER-EASVKRNQTR 384
+E + + + ++ I+ +++ ++E + S+E+ A ++ ++ +
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKK 2316
Query: 385 EFDGTEVLKGDERQDLTLSPRLE 407
+ + LK E L R+E
Sbjct: 2317 QLCVLQQLKESEHHADLLKGRVE 2339
Score = 55.1 bits (131), Expect = 1e-07
Identities = 68/288 (23%), Positives = 132/288 (45%), Gaps = 38/288 (13%)
Query: 106 LQRTNELK-KRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKIS 164
+++ N++ K L R + ++ + LQ+E + N+ EL + + +QLK
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Query: 165 GFSTAEIRKDISAMEEEKDQLIKR-------VEHLKKRVETAQNHQ-WMLKIARQLRVE- 215
+E++K + M KDQ+ K E+ + E + HQ +L +Q VE
Sbjct: 2668 TLENSELKKSLDCM--HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEI 2725
Query: 216 -------KEREEYLAQQKQE------QKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESL 262
+EE L+ QK E K +L ++++ ++ +LK + + K +
Sbjct: 2726 QTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM--DNLKYVNQ 2783
Query: 263 MKRLEEEIKFNLYMVTEKFPKELENKK----KELHFLQKVVSEPAMGHSDLLELESKINE 318
+K+ E + + ++ K K+LE +K KEL LQ + G +++K++E
Sbjct: 2784 LKKENERAQGKMKLLI-KSCKQLEEEKEILQKELSQLQAAQEKQKTG----TVMDTKVDE 2838
Query: 319 INTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAK 366
+ TEI +L K+ + + E L + + +IS +K KA+E+ E +
Sbjct: 2839 LTTEIKEL--KETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884
Score = 49.3 bits (116), Expect = 7e-06
Identities = 66/314 (21%), Positives = 139/314 (44%), Gaps = 37/314 (11%)
Query: 113 KKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLK----ISGFST 168
K+R L K E E L D+ ++ T K+ + L+ A + KEYE+LK +
Sbjct: 565 KQRDCSQDLLKKREHHIEQLNDK-LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVETAQ--NHQWMLKIARQLRVEKEREEYLAQQK 226
+E K ++ ME EK+ L ++ HL+ ++T Q +H++ ++ +E +RE + +
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR---TLEMDRENLSVEIR 680
Query: 227 QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELE 286
H V + V+ + + + K E ++ ++EI+ N+ + T + ++E
Sbjct: 681 N------LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIE-NMCLKTSQLTGQVE 733
Query: 287 NKKKELHFLQKVVSEPAMGHSDL-LELES-----KINEINTEINQLIEKKMMR--NEPI- 337
+ + +L L + + + DL E ES K + + N+ ++ ++ +P
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 338 -EGKLSLYRQQASIISRKKEAKAEELQEAKEKLA----------SLEREASVKRNQTREF 386
++ +Q S+ S + E + E Q K SLE + + + ++
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853
Query: 387 DGTEVLKGDERQDL 400
+ +KG+ ++L
Sbjct: 854 EELVQIKGEIEENL 867
Score = 48.9 bits (115), Expect = 9e-06
Identities = 74/292 (25%), Positives = 128/292 (43%), Gaps = 43/292 (14%)
Query: 113 KKRAYLARFLIKLEVPSEFLQDETV-ADTNKQYEELMEAFKTLHKEYEQLKISGFSTA-- 169
KK+ ++A L + E ++ L+D+ + Q E + L E + ++ T
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE 2192
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH----QWMLKIARQLRVEKEREEYLAQQ 225
E+ + + E + L E+L K+++ Q +L + L EKE+ E Q
Sbjct: 2193 EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI--QI 2250
Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQA-AADAKPESLMKRLEEEI------KFNLYMVT 278
K+E K + + +QNQLK + +A AA + +MK E+ + + L
Sbjct: 2251 KEESKTAV-------EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI 2303
Query: 279 EKFPKELE-NKKKELHFLQKVVSEPAMGHSDLL-------ELESKINEINTEINQLIEKK 330
EK LE ++KK+L LQ++ + + H+DLL E E +I N E + +E +
Sbjct: 2304 EKLRARLEADEKKQLCVLQQL--KESEHHADLLKGRVENLERELEIARTNQE-HAALEAE 2360
Query: 331 MMRNE------PIEGKLSLYRQ---QASIISRKKEAKAEELQEAKEKLASLE 373
+ E IEG R I +KE ELQ+ +E+++ LE
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Score = 43.1 bits (100), Expect = 5e-04
Identities = 73/335 (21%), Positives = 137/335 (40%), Gaps = 35/335 (10%)
Query: 106 LQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEY---EQLK 162
L+ K A L + LE E Q + +D KQ EEL++ + + EQ+
Sbjct: 816 LEADQSPKNSAILQNRVDSLEFSLES-QKQMNSDLQKQCEELVQIKGEIEENLMKAEQMH 874
Query: 163 ISGFST-----AEIRKDISAMEEEKDQLIKRVEHLKK-------RVETAQNHQWMLKIAR 210
S + +++++D SA + + + +E+ +K +VET Q LK +
Sbjct: 875 QSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934
Query: 211 QLRVEKERE-----EYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKR 265
L + +E E L+ +K+E + + + ++ + + ++++ A E +
Sbjct: 935 HLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLI 994
Query: 266 LEEEIKFNLYMVTEKFPKELENK-KKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324
+ E N EK EL ++ K+E L + E + DL + E N+++
Sbjct: 995 QKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054
Query: 325 QLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTR 384
L+ + SL + + + + KEA A+E QE KLA E +N
Sbjct: 1055 CLLNECT----------SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER---NQNLML 1101
Query: 385 EFDGTEVLKGDERQDLTLSPRLECGGVIMAYCSLK 419
E + + E D + + E GG+ +LK
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLK 1136
Score = 42.7 bits (99), Expect = 6e-04
Identities = 71/305 (23%), Positives = 122/305 (40%), Gaps = 74/305 (24%)
Query: 110 NELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTA 169
N K + L + LE + L +E + D ++ Y++L H EYE L+
Sbjct: 720 NMCLKTSQLTGQVEDLEHKLQLLSNE-IMDKDRCYQDL-------HAEYESLR------- 764
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRV----ETAQNHQWMLKIARQLRVEKEREEYLAQQ 225
++ + L+ +H + + + A +H + I Q + ER E +
Sbjct: 765 ------DLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA 818
Query: 226 KQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP-------------ESLMK-------- 264
Q KN R+ ++ L+S +Q +D + E+LMK
Sbjct: 819 DQSPKNSAI-LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSF 877
Query: 265 ---------RLEEEIKFNLYMVTEKFPKELENKKKELHFL-QKVVSEPAMGHSDLLELES 314
+L+E+ + +V E LENK+KEL L KV +E A ++ EL+
Sbjct: 878 VAETSQRISKLQEDTSAHQNVVAETL-SALENKEKELQLLNDKVETEQA----EIQELKK 932
Query: 315 KINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE----AKEKLA 370
N L+E + + + LSL +++ S I + + EEL + KE A
Sbjct: 933 S--------NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 371 SLERE 375
SL +E
Sbjct: 985 SLNQE 989
Score = 40.8 bits (94), Expect = 0.002
Identities = 51/249 (20%), Positives = 111/249 (44%), Gaps = 33/249 (13%)
Query: 134 DETVADTNKQYEELME----AFKTLHKEYEQLKISGFSTAEIRKDI-SAMEEEKDQLIKR 188
++ + + K+++E + +F+TL +E Q+K + K++ + ++ E D+L
Sbjct: 386 EQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV 445
Query: 189 VEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLK 248
+ L+ +E + + + R E Q Q ++N+L +++ +++ N LK
Sbjct: 446 KQQLENNLE-------------EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 249 SMRQAAADAKPESLMKRLEEEIKFNLYMV---TEKFPKELENKKKELHFLQKVVSEPAMG 305
S + A + LE E+K N+ ++ F +E++ K + + + E
Sbjct: 493 SHSEQKARE-----VCHLEAELK-NIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
Query: 306 HSDLLELES-KINEINTE-----INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKA 359
+ L LE K+ + E L++K+ E + KLS +++ + E K
Sbjct: 547 QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606
Query: 360 EELQEAKEK 368
+E +E KE+
Sbjct: 607 KEYEELKEE 615
Score = 40.0 bits (92), Expect = 0.004
Identities = 52/260 (20%), Positives = 110/260 (42%), Gaps = 28/260 (10%)
Query: 143 QYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH 202
Q +EL E LH + E K + + +E EK QL++ ++ K Q+
Sbjct: 2446 QLKELNERVAALHNDQEACKAK---EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 203 QWMLKIARQLRVEKEREEYLAQQKQEQKNQLF---HAVQRLQRVQNQLKSMRQAAADAKP 259
+ + +++ K++ E ++ KNQ+ V +L +V+ + + ++ + +
Sbjct: 2503 --VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR- 2559
Query: 260 ESLMKRLEEEIKF---------NLYMVTEKFPKELEN-----KKKELHFLQKVVSEPAMG 305
+L LE++I+ + V + K LEN K ++ F++KV A
Sbjct: 2560 -NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 306 HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365
EL+ +++E+ + +L E+ + G+L L ++ + + E E
Sbjct: 2619 ----TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
Query: 366 KEKLASLEREASVKRNQTRE 385
K+ L + ++ K + RE
Sbjct: 2675 KKSLDCMHKDQVEKEGKVRE 2694
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 55.1 bits (131), Expect = 1e-07
Identities = 68/285 (23%), Positives = 136/285 (47%), Gaps = 31/285 (10%)
Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
E ++ Q+E + K E+L + + + +E E+L G ++ + + +++++
Sbjct: 1765 EEETKLAQEEELLIQEK--EKLAQHKEKMPEEEERL---GRKREQLIEKKMKLAQKRERW 1819
Query: 186 IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQE---QKNQLFHAVQRLQR 242
I +E L K + + + + L EKE+ LAQ+K+ K +L H+ ++L +
Sbjct: 1820 INSMEELTKNKMILYQKKNLAQEKKNLAQEKEK---LAQRKENLLYNKERLTHSKKQLVQ 1876
Query: 243 VQNQLKSMRQAAADA------KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHF 294
V+N+L + A + E+++K+ E+ E + L V + K+ E +E
Sbjct: 1877 VKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQE--- 1933
Query: 295 LQKVVSEPAM--GHSDL---LELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQAS 349
K+ E AM G L L++ + +N E+ +L E+KM +EGK +L + +
Sbjct: 1934 KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM---RLVEGKETLSKGETP 1990
Query: 350 IISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKG 394
SR+++ E QE E+ SLE + + ++ + +E+ KG
Sbjct: 1991 ETSRQRKMTQVE-QELFERKLSLEEKILLHEDRILAMEESEIAKG 2034
Score = 43.5 bits (101), Expect = 4e-04
Identities = 61/280 (21%), Positives = 120/280 (42%), Gaps = 34/280 (12%)
Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK 182
KL E LQ+ D ++EE + ++ L + ++ + + +++S EEK
Sbjct: 1502 KLSPEEEMLQE----DKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK 1557
Query: 183 DQ-LIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER---EEYLAQQKQ---EQKNQLFH 235
+Q + + H++ + H+W ++ R EK+R E LAQ+++ +++ QL
Sbjct: 1558 EQQVTEEQRHIQ------EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611
Query: 236 AVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFL 295
++L Q +K + A+ E + EE L EK +E E ++ L
Sbjct: 1612 EERKL--AQAYVKITQDDREMAQAEGKFAQKEE----TLAQRGEKLSQEAEKLAQKRKKL 1665
Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIIS--- 352
K + A L + K+ E+ + Q +E+ R + ++ + Q+ +
Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDM 1725
Query: 353 -----RKKEAKAEE--LQEAKEKLASLEREASVKRNQTRE 385
+++E EE L E K+KLA E + +R + E
Sbjct: 1726 EELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSE 1765
Score = 43.1 bits (100), Expect = 5e-04
Identities = 58/261 (22%), Positives = 112/261 (42%), Gaps = 31/261 (11%)
Query: 143 QYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNH 202
Q +EL + + L + E+L + E+ ++ + EEK +L + E L + E
Sbjct: 1710 QEKELAQELEELEWDMEELS---WKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
Query: 203 QWMLKIARQLRVEKEREEYLAQQKQE----------QKNQLFHAVQRL-QRVQNQLKSMR 251
+ K+A++ + + +E LAQ K++ ++ QL +L Q+ + + SM
Sbjct: 1767 E--TKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME 1824
Query: 252 QAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHS--DL 309
+ + K L +E K NL EK + EN + ++ + HS L
Sbjct: 1825 ELTKNKMILYQKKNLAQEKK-NLAQEKEKLAQRKEN---------LLYNKERLTHSKKQL 1874
Query: 310 LELESKINEINTEINQLIEKKMMRNEPI---EGKLSLYRQQASIISRKKEAKAEELQEAK 366
+++++K+ N + Q+ EK E + + KL+ ++ + K E+L + K
Sbjct: 1875 VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEK 1934
Query: 367 EKLASLEREASVKRNQTREFD 387
KLA + K+ E D
Sbjct: 1935 MKLALEKAMVQGKKRLRGELD 1955
Score = 40.8 bits (94), Expect = 0.002
Identities = 64/297 (21%), Positives = 125/297 (42%), Gaps = 42/297 (14%)
Query: 113 KKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHK-EYEQLKISGFSTAEI 171
+K A +R LIK E L E A NK + L + + K E++K++ A
Sbjct: 2050 RKLAKASRKLIKKR---ESLSKEP-AKLNKILKALQKLTRDERKLTQEEIKMTKMKRALF 2105
Query: 172 RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWML----KIARQLRVEKEREEYLAQQKQ 227
K+ E+ IK + +KR E ++ + + K+A ++R +EE + +++
Sbjct: 2106 VKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEES 2165
Query: 228 EQKNQLFHAV------------QRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLY 275
+ + + + + ++ + + ++A KP+ +E++
Sbjct: 2166 KLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESE-- 2223
Query: 276 MVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNE 335
E F +E+E+ EL + + SE E E + E E ++ E++ R E
Sbjct: 2224 ---EHFSEEMESLLDELEKQESLSSE---------EEEEREEEEEREEEEVREEEEERKE 2271
Query: 336 PIEGK-LSLYRQQASIISRKKEAKAEELQE------AKEKLASLEREASVKRNQTRE 385
EG+ + +++ +KKE K EE+QE KE++ S E S+ + E
Sbjct: 2272 EEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEE 2328
Score = 38.1 bits (87), Expect = 0.016
Identities = 34/144 (23%), Positives = 66/144 (45%), Gaps = 11/144 (7%)
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ 229
E+ K S EE+++ + E ++ V + + + + +VEKE EE ++K+++
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
Query: 230 KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKK 289
K ++ Q + + + ++ + ESL EEE +L E+ +E E K
Sbjct: 2296 KEEV-------QEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL---EEEVDREKEILK 2345
Query: 290 KELHF-LQKVVSEPAMGHSDLLEL 312
KE F LQ+ + G +L +
Sbjct: 2346 KEKQFKLQEQRRKSLRGRERVLSI 2369
Score = 31.6 bits (70), Expect = 1.5
Identities = 35/163 (21%), Positives = 72/163 (44%), Gaps = 13/163 (7%)
Query: 139 DTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVET 198
D + E E ++L E E+ + E R++ EEE+ ++ E +K E
Sbjct: 2218 DEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE---VREEEEERKEEEE 2274
Query: 199 AQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAK 258
+ Q + + + +KE+++ Q+K+E +F + + + ++ +D +
Sbjct: 2275 GEEKQVEKEEEEKKKKKKEKKKEEVQEKEE----VFEEKEEIMSEEE-----TESLSDEE 2325
Query: 259 PESLMKRLEEEI-KFNLYMVTEKFPKELENKKKELHFLQKVVS 300
E LEEE+ + + EK K E ++K L ++V+S
Sbjct: 2326 EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLS 2368
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 55.1 bits (131), Expect = 1e-07
Identities = 68/282 (24%), Positives = 124/282 (43%), Gaps = 29/282 (10%)
Query: 111 ELKKRAY-LARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTA 169
ELKKR L ++ + +D V D + Q L E L K++ + S S +
Sbjct: 1988 ELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS 2047
Query: 170 EIRKDISAMEEE---KDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQK 226
I D E+ K+ L E+++ + + Q ++ + ++ Q+R KE E+L ++K
Sbjct: 2048 GIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEK 2107
Query: 227 QEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI--------KFNLYMVT 278
E + +L H V+ +S + K LMK++ E++ K + + +
Sbjct: 2108 AEVQRKLGH-------VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS 2160
Query: 279 EKFPK-ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEI--NQLIEKKMMRNE 335
EK E EN+K + L+K+ + +GH + ESK I N+ + K++ +
Sbjct: 2161 EKMANIEQENEKLKAE-LEKLKAH--LGHQLSMHYESKTKGTEKIIAENERLRKELKKET 2217
Query: 336 PIEGKLSLYRQQASIISRKKEAKAEE----LQEAKEKLASLE 373
KL + + I++ K + EE LQ A+ + LE
Sbjct: 2218 DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLE 2259
Score = 45.4 bits (106), Expect = 1e-04
Identities = 58/267 (21%), Positives = 112/267 (41%), Gaps = 40/267 (14%)
Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQW 204
+E K L ++ EQ T E+ K+ +E+ K++L + +T Q
Sbjct: 358 QERDSQIKMLTEQVEQY------TKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
Query: 205 MLKIARQLRVEKEREEYLAQQKQEQKN-QLFHAVQRLQRVQNQLKSMRQAAADAKPESLM 263
L I ++ E ER LA+ +K+ +L A++RL+ ++ + + A + +
Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVE------I 465
Query: 264 KRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINE-INTE 322
K + +IK + +E+ L K +++ + SD L+ + E + E
Sbjct: 466 KNCKNQIKI---------------RDREIEILTKEINKLELKISDFLDENEALRERVGLE 510
Query: 323 INQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
+I+ RN K YR + I+ ++ E+ EE + K+K+ + +E KR+
Sbjct: 511 PKTMIDLTEFRNSK-HLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERG-KRSA 568
Query: 383 TREFDGTEVLKGDERQDLTLSPRLECG 409
T G +DL L+ + G
Sbjct: 569 T---------SGLTTEDLNLTENISQG 586
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/238 (22%), Positives = 106/238 (44%), Gaps = 25/238 (10%)
Query: 174 DISAMEEEKDQLI---KRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQ- 229
D+ EE D L+ +VE + + E +N + +I + L K +E LA ++ E+
Sbjct: 17 DLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
Query: 230 -------KNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP 282
+NQL V +L+ N+L+ +Q+A L + + L E+
Sbjct: 77 GEEQAKFENQLKTKVMKLE---NELEMAQQSAGGRDTRFLRNEICQ-----LEKQLEQKD 128
Query: 283 KELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLS 342
+ELE+ +KEL +KV + A+ + + SK+ N + + + + + + I+ +
Sbjct: 129 RELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKK--KNEQLCQDIIDYQKQ 186
Query: 343 LYRQQASIISRKKEAKAEELQEAKEKLASL----EREASVKRNQTREFDGTEVLKGDE 396
+ Q+ +++SR+ E Q +K+ + E + + N+ E E+ K E
Sbjct: 187 IDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLE 244
Score = 40.8 bits (94), Expect = 0.002
Identities = 51/294 (17%), Positives = 123/294 (41%), Gaps = 32/294 (10%)
Query: 117 YLARFLIKLEVPSEFLQ--DETVADTNKQYEELMEAFKTLHKEY---------------- 158
YL L +LE + L+ ++++ D N+++ + L+KEY
Sbjct: 783 YLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKE 842
Query: 159 ------EQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQL 212
+Q++ E ++A++ + D++ K + +++ Q ++ + RQ
Sbjct: 843 EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE--KSLIRQY 900
Query: 213 RVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKF 272
E E L ++ ++QKN+L + L+ ++ A K +L K ++ +
Sbjct: 901 TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAI-FKIAALQKVVDNSVSL 959
Query: 273 NLYMVTEKFPKELENKKKEL----HFLQKVVSEPAMGHSDLLELESKINEINTEINQLIE 328
+ + K EL K +++ + L + S + + L+ ++ IN E+ ++ +
Sbjct: 960 SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL-EITK 1018
Query: 329 KKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
+K+ E + + ++S+ KK ++ +K+ LE + +R +
Sbjct: 1019 EKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQR 1072
Score = 37.0 bits (84), Expect = 0.035
Identities = 44/254 (17%), Positives = 110/254 (43%), Gaps = 37/254 (14%)
Query: 141 NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVET-A 199
NKQY EL ++ + ++ L + + + +++E+ + + K +E K+++ T
Sbjct: 966 NKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE 1025
Query: 200 QNHQWMLKIARQLRVEKEREE--------------YLAQQKQEQKNQLFHAVQRLQRVQN 245
Q + K+ + ++K ++ L ++ ++ + H + + ++
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085
Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMG 305
LK M + + L + E K NL +K + L ++ + + K VS+
Sbjct: 1086 SLKQMEE-----RNFELETKFAELTKINL--DAQKVEQMLRDELAD--SVSKAVSD--AD 1134
Query: 306 HSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEA 365
+LELE E+ E+++L E + R+Q I++ +++++ +E++
Sbjct: 1135 RQRILELEKNEMELKVEVSKLREIS-----------DIARRQVEILNAQQQSRDKEVESL 1183
Query: 366 KEKLASLEREASVK 379
+ +L + ++ K
Sbjct: 1184 RMQLLDYQAQSDEK 1197
Score = 37.0 bits (84), Expect = 0.035
Identities = 60/277 (21%), Positives = 117/277 (42%), Gaps = 51/277 (18%)
Query: 147 LMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEK--------------DQLIKR-VE 190
L+E K+ L + +Q K + E+R +++A EE+ Q++ R
Sbjct: 1726 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR 1785
Query: 191 HLKKRVETAQNHQWMLKIARQLRVEKEREEYLA----------QQKQEQKNQLFHAVQRL 240
LK +VE + +LK+ L+ K RE L Q+KQ+ N++ + +
Sbjct: 1786 ELKTQVEDLNEN--LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEI 1843
Query: 241 QRVQNQLKSMRQ---AAADAKP------------ESLMKRLEEEIKFNLYMVTEKFPKEL 285
+ ++LK + + KP + +K+LE +++ + V K P +
Sbjct: 1844 DQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLK-PMKE 1902
Query: 286 ENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYR 345
+N K+EL ++ A +L+ K E+ T QL K + + + KL+L R
Sbjct: 1903 KNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQR 1962
Query: 346 QQAS-------IISRKKEAKAEELQEAKEKLASLERE 375
+ + ++ + +EL+E K++ LE +
Sbjct: 1963 KLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEND 1999
Score = 31.6 bits (70), Expect = 1.5
Identities = 40/209 (19%), Positives = 95/209 (45%), Gaps = 36/209 (17%)
Query: 180 EEKDQLI--------KRVEHLKKRVETAQNH-QWMLKIARQ-------LRVEKEREEYLA 223
+EK+Q + R +HL++ +++ + L +A+Q ++++ ++ + +
Sbjct: 1243 DEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQ 1302
Query: 224 QQKQEQK------NQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMV 277
+ K Q+ N+ +L+ ++ + +++ K + ++EE L +
Sbjct: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEE-----LRLQ 1357
Query: 278 TEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPI 337
K +EL K+E+ +L ++SE S L E + N+ + E ++ R +
Sbjct: 1358 ELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ---REVDL 1414
Query: 338 EGKLSLY-RQQASIISRKKEAKAEELQEA 365
E +L ++ RQQ I++ A++ +EA
Sbjct: 1415 ERQLDIFDRQQNEILN-----AAQKFEEA 1438
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 54.3 bits (129), Expect = 2e-07
Identities = 83/385 (21%), Positives = 158/385 (41%), Gaps = 37/385 (9%)
Query: 23 LITFDSLEPMQLLQVLSDVLAE-IDPKQLVDIREEMPEQTAKRMLSLLGILKYKPS-GNA 80
L+T S E L Q L + E + KQ+ D+ E+ Q A + + + S A
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 81 TDMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADT 140
+ R + + + L L + ++ A L + L++++ L D +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT----LMDNMTLER 244
Query: 141 NKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRV-ETA 199
++ E+L + K L +Y S + +++R +++ +E ++ ++ LK V E
Sbjct: 245 ERESEKLKDECKKLQSQYAS---SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT 301
Query: 200 QNHQWMLKIARQLRV------EKEREEYLAQQK------------QEQKNQLFHAVQRLQ 241
Q +Q + + + EK EE ++++ Q+ +++L + L
Sbjct: 302 QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
Query: 242 RVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSE 301
R+ +L +A K E E E K+ ++ E + + ++KE H LQ + SE
Sbjct: 362 RIHVELSEKGEATQKLKEELS----EVETKYQ-HLKAEFKQLQQQREEKEQHGLQ-LQSE 415
Query: 302 PAMGHSDLLELESKINEIN---TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAK 358
HS LLE E ++ E + E QL +K+M E L L + ++K
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 359 AEELQEAKEKLASLEREASVKRNQT 383
+ ELQ +K +E + T
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQST 500
Score = 50.4 bits (119), Expect = 3e-06
Identities = 49/276 (17%), Positives = 118/276 (42%), Gaps = 33/276 (11%)
Query: 132 LQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE- 190
LQ T A + +L + + + + ++++ + +++IS +E+E++ L +++
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 191 ---------HLKKRVETAQNHQWML--KIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
L+++ T Q L K+ Q K+ +E L Q QEQK L A R
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFP---------------KE 284
+ ++ + + ++K + ++ + K L + E
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 285 LENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKM---MRNEPIEGKL 341
L++K++EL+ K+ ++ + L + + +++ + + + EK + + E +EG++
Sbjct: 676 LQDKQQELN---KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 342 SLYRQQASIISRKKEAKAEELQEAKEKLASLEREAS 377
+ + KE ++LQ+ ++ LE A+
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768
Score = 50.1 bits (118), Expect = 4e-06
Identities = 74/362 (20%), Positives = 155/362 (42%), Gaps = 59/362 (16%)
Query: 48 KQLVDIREEMPEQTAKRMLSLLGI------LKYKPSGNATDMSTFRQGLVIGSKPVIYPV 101
K+LV ++ M T +R + L+ + + + +S R L G + V V
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV 287
Query: 102 --LHWLLQRTNEL-KKRAYLARFLIKLEVPSEFLQD----ETVADTN------------K 142
L L NEL +K L L+K E L++ E+V+ N +
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Query: 143 QYEELMEAFKT-LHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
Q + + A +T LH+ + +L G +T ++++++S +E + +HLK
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET-------KYQHLKAEF----- 395
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQ----LFHAVQRLQRVQNQLKSMRQAAADA 257
+QL+ ++E +E Q Q + NQ L ++L +LK RQ ++
Sbjct: 396 --------KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS-- 445
Query: 258 KPESLMKRLEE--EIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESK 315
E LM + ++ +++ L + E+ +++ N + H L K + + +K
Sbjct: 446 --EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 316 INEINTEINQLIEK---KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
+ E ++ Q++ + K + + +E L ++ S++ +++E ++Q + + A L
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 373 ER 374
+
Sbjct: 564 NQ 565
Score = 46.2 bits (108), Expect = 6e-05
Identities = 53/267 (19%), Positives = 121/267 (45%), Gaps = 44/267 (16%)
Query: 137 VADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE-EKDQLIKRVEHLKKR 195
+ + NK +EL A TL ++ S ++++ A+++ +K++ +K E + ++
Sbjct: 1070 IGNQNKLIQELKTAKATLEQD------SAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Query: 196 VETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN--QLKSMRQA 253
+ A+ +++ +E+E + + +E K+ +++ + +++ QL ++
Sbjct: 1124 SKLAE--------IEEIKCRQEKE--ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 254 AADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELE 313
K +SL +E+E K N ++ ++ KE E KKE + + A HS++ E E
Sbjct: 1174 ELQGKADSLKAAVEQE-KRNQQILKDQVKKEEEELKKEF------IEKEAKLHSEIKEKE 1226
Query: 314 SKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLE 373
M ++E E KL++ Q + ++ +E Q ++ +++ LE
Sbjct: 1227 VG---------------MKKHEENEAKLTM---QITALNENLGTVKKEWQSSQRRVSELE 1268
Query: 374 REASVKRNQTREFDGTEVLKGDERQDL 400
++ R + + T DER+ L
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRAL 1295
Score = 39.7 bits (91), Expect = 0.005
Identities = 52/286 (18%), Positives = 114/286 (39%), Gaps = 35/286 (12%)
Query: 114 KRAYLARFLIKLEVPSEFLQD--ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEI 171
K+ L + +L+ + LQD E + +E E + +L ++ E+L+
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 172 RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKN 231
++ A +E+ Q +++ L +E ++++QL +EKE Q++
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRAT-----ELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 232 QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLE-------------------EEIKF 272
L Q+L + + + + ++Q E+ ++ E E +
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 273 NLYMVTEKFPK---ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEK 329
L V +K K L+N K E E G + +L+LE E+ ++ +E
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFE------KENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 330 KMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
+ + ++ L ++ + + + + E+L +A+ L E+E
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Score = 37.4 bits (85), Expect = 0.027
Identities = 46/221 (20%), Positives = 101/221 (45%), Gaps = 27/221 (12%)
Query: 192 LKKRVETAQN-----HQWMLKIARQLRVE----KEREEYLAQQK---QEQKNQLFHAVQR 239
L+ ++TAQN Q + KI QL ++++E+ +Q + +E K + Q+
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 240 LQRVQNQLKSMRQAAADAKP--ESLMKRLEEEIKFN--LYMVTEKFPKELENKKKELHFL 295
+ ++ Q+K + + + K E ++ L+++ + N L + + K+LE +K+
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE----- 779
Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
+VS + DL + + I ++ + E+K + + E + Q ++ +
Sbjct: 780 --IVSSTRL---DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834
Query: 356 EAKAEELQEAK-EKLASLEREASVKRNQTREFDGTEVLKGD 395
+ ELQ+ K EK A + ++VK ++ D + K +
Sbjct: 835 QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 53.5 bits (127), Expect = 4e-07
Identities = 68/305 (22%), Positives = 135/305 (44%), Gaps = 47/305 (15%)
Query: 87 RQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEE 146
R G V K +L L + ++ Y+ + + + PS L T+ D EE
Sbjct: 161 RLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITD-----EE 215
Query: 147 LMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWML 206
L E AE+++ + +E EK ++ V+ LK+++E AQ +L
Sbjct: 216 LKE-----------------KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQ----LL 254
Query: 207 KIARQLRVE-----KEREEYLAQ-QKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPE 260
+QL+VE KE + A+ Q Q ++N+L++ + + Q + K RQ + E
Sbjct: 255 LPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQ----QQEEKMWRQEEKIQEQE 310
Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
K E+E+K + +++ +++++H ++ + E + E KI E
Sbjct: 311 E--KMCEQELKI------REQEEKMWRQEEKMHEQEEKIREQ---EDKMWRQEEKIREQE 359
Query: 321 TEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKR 380
+I + EK + E I + ++Q + R++E E+ ++ +EK+ E++ +
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 381 NQTRE 385
+ RE
Sbjct: 420 EKIRE 424
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/246 (20%), Positives = 116/246 (47%), Gaps = 20/246 (8%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
+Q E++ E + + ++ E++ +IR+ ++E+++++ ++ E ++++ E Q
Sbjct: 350 RQEEKIREQEEKIREQEEKM---WRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQE 406
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAAD-AKPE 260
W RQ + +E++E + +Q++E Q + + +Q+Q + +R+ + E
Sbjct: 407 KMW-----RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Query: 261 SLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEIN 320
M+ EE+I+ + E+ K +K L K + + E K+ E
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEK-----LLKQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 321 TEINQLIEKKMMRNEPI-EGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVK 379
++ + EK + E + E ++ L++Q+ K + + LQE +E+L L ++A +
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQE-----EKMQEQEVRLQELEERLGKLGQKAELL 571
Query: 380 RNQTRE 385
RE
Sbjct: 572 GGAGRE 577
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 53.5 bits (127), Expect = 4e-07
Identities = 67/279 (24%), Positives = 128/279 (45%), Gaps = 27/279 (9%)
Query: 113 KKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIR 172
KK A R L E S+ Q E+L + L +E +QL S +
Sbjct: 1801 KKLAQTKRVLAAAEENSKMEQSNL--------EKLELNVRKLQQELDQLNRDKLS---LH 1849
Query: 173 KDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQ--LRVEKEREEYLAQQKQEQK 230
DISAM+++ + + V L++ + Q+H L +A+Q L K ++ L++Q + QK
Sbjct: 1850 NDISAMQQQLQEKREAVNSLQEELANVQDH---LNLAKQDLLHTTKHQDVLLSEQTRLQK 1906
Query: 231 --NQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKF-NLYMVTEKFPKELEN 287
++ + + Q+ + + Q + E+ +K +++E+ F L E +LE
Sbjct: 1907 DISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLET 1966
Query: 288 K----KKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
K++ H L+K +++ S L ++ SK+ + L E++ E +E LS
Sbjct: 1967 SKVTLKEQQHQLEKELTDQ---KSKLDQVLSKVLAAEERVRTLQEEERW-CESLEKTLSQ 2022
Query: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQ 382
++Q S ++ K+ EL +++ S+ + S+ RNQ
Sbjct: 2023 TKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ 2061
Score = 47.0 bits (110), Expect = 3e-05
Identities = 62/282 (21%), Positives = 122/282 (43%), Gaps = 58/282 (20%)
Query: 110 NELKKRAYLARFLIKLEVPSEFLQ---DETVADTNKQYEELMEAFKTLHKEYEQLKISGF 166
N ++K R L++ E +E L+ ET + K ++L + + K+ EQ KI
Sbjct: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQL-RSLQADAKDLEQHKIKQE 1516
Query: 167 STA-EIRK-------DISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER 218
EI K D + ++K++L + ++ L+K +E A+ ++ L+V KE
Sbjct: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNE-----DHHLQVLKES 1571
Query: 219 EEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVT 278
E L ++ E L+++++Q+ S +Q A
Sbjct: 1572 EVLLQAKRAE-----------LEKLKSQVTSQQQEMA----------------------- 1597
Query: 279 EKFPKELENKKKELHFLQKVVSEPAMGHSDLL-----ELESKINEINTEINQLIEKKMMR 333
++L +KK+ELH LQ + + + L E+ K N I E+ L+E+ +
Sbjct: 1598 -VLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIR-EVKSLLEELSFQ 1655
Query: 334 NEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLERE 375
+ ++S + Q ++I ++ E + E LQ +++ + E
Sbjct: 1656 KGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Score = 43.1 bits (100), Expect = 5e-04
Identities = 54/264 (20%), Positives = 112/264 (42%), Gaps = 34/264 (12%)
Query: 140 TNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETA 199
+ K+ EEL L +E + L+ E+ + + +++KD + VE L +E
Sbjct: 1352 SEKEMEELHHNIDDLLQEKKSLECE---VEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408
Query: 200 QN--------------HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQN 245
++ + +LK +LR E + LA+ + E +++ +
Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELR---EADRLLAEAESELSCTKEKTKNAVEKFTD 1465
Query: 246 QLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKF------PKELENKK-KELHFLQKV 298
+S+ Q +DA+ ++R +E NL ++ K+LE K K+ L+++
Sbjct: 1466 AKRSLLQTESDAEE---LERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEI 1522
Query: 299 VSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAK 358
A SD L K ++ E+ +L + M + L + ++ ++ +AK
Sbjct: 1523 NKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLL----QAK 1578
Query: 359 AEELQEAKEKLASLEREASVKRNQ 382
EL++ K ++ S ++E +V Q
Sbjct: 1579 RAELEKLKSQVTSQQQEMAVLDRQ 1602
Score = 42.7 bits (99), Expect = 6e-04
Identities = 71/338 (21%), Positives = 141/338 (41%), Gaps = 43/338 (12%)
Query: 88 QGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIK--LEVPSEFLQDETVA-DTNKQY 144
+G++ G + + + Q NE +K L++ EV E Q E VA D
Sbjct: 615 EGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMR 674
Query: 145 EELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIK----RVEHLKKRVETAQ 200
+EL E L +++E S + + D+SA E E + + LK+ +E
Sbjct: 675 KELAELESALQEQHEV----NASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVT 730
Query: 201 NHQWMLKIARQLRVEKERE-------EYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQA 253
+ + A Q +EKER+ + +++EQ+N HA +L+ +Q+
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHA--KLKHLQDD------- 781
Query: 254 AADAKPESLMKRLEEEIKFNLYMVTEKF--PKELENKKKELHFLQKVVSEPAMGHS---- 307
+L+K+ ++ + +L V + P+E+ + EL K+ + HS
Sbjct: 782 ------NNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDV 835
Query: 308 ---DLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQE 364
L +L+ + +EI ++ +R ++ +++L +++ + + E E
Sbjct: 836 LGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALE 895
Query: 365 AKEKLASLEREASVKRNQTREFDGTEVLKG-DERQDLT 401
A+ + EA +++ + E LK +E Q LT
Sbjct: 896 ARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLT 933
Score = 42.7 bits (99), Expect = 6e-04
Identities = 57/249 (22%), Positives = 110/249 (44%), Gaps = 40/249 (16%)
Query: 170 EIRKDISAMEEEKDQLIKRVEHLKKRVETAQ--NHQWM-LKIARQLRV------------ 214
EI K+ ++ Q+ K LK ++ Q NH+ LK+ RV
Sbjct: 1676 EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE 1735
Query: 215 EKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNL 274
EK E L Q Q+QK ++ Q L+R + +++ R A +S ++ L +E K +L
Sbjct: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIE--RMTAESRALQSCVECLSKE-KEDL 1792
Query: 275 YMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRN 334
+ + K+L K+ L ++ M S+L +LE + ++ E++QL K+ +
Sbjct: 1793 QEKCDIWEKKLAQTKRVLAAAEE---NSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLH 1849
Query: 335 EPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKG 394
I S + ++ + K E + +E+LA+++ ++ + ++L
Sbjct: 1850 NDI-----------SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQ--------DLLHT 1890
Query: 395 DERQDLTLS 403
+ QD+ LS
Sbjct: 1891 TKHQDVLLS 1899
Score = 42.0 bits (97), Expect = 0.001
Identities = 58/297 (19%), Positives = 127/297 (42%), Gaps = 44/297 (14%)
Query: 95 KPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTL 154
K ++Y L LQ N+L++ A + LE+ E Q + +A K+ ++L A +L
Sbjct: 491 KDLLYKQLSGRLQLVNKLRQEA------LDLELQME-KQKQEIAGKQKEIKDLQIAIDSL 543
Query: 155 HKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRV 214
+ + + ++ S E++ D + K+ + L+ R++ + + +IA++
Sbjct: 544 DSKDPK-------HSHMKAQKSGKEQQLDIMNKQYQQLESRLD-----EILSRIAKETEE 591
Query: 215 EKEREEYLAQQK----QEQKNQLFHAVQRLQRVQNQLKSMRQAAADA------KPESLMK 264
K+ EE L + + + K L + LQ +K A + + E+L++
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 651
Query: 265 RLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEIN 324
RL E + + E + EN +KEL L+ + E ++ L + + ++ E+
Sbjct: 652 RLTEVEQERDQL--EIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709
Query: 325 QLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRN 381
+ + + + + +++ ++R + + LQ A LE+E +N
Sbjct: 710 ARLNLR-------DAEANQLKEELEKVTRLTQLEQSALQ------AELEKERQALKN 753
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/228 (22%), Positives = 101/228 (44%), Gaps = 25/228 (10%)
Query: 172 RKDISAMEEEKDQLIKRVEHLKKRVETAQNHQ--WMLKIARQLRVEKEREEYLAQQKQEQ 229
+++I M E L VE L K E Q W K+A+ RV EE K EQ
Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEE---NSKMEQ 1821
Query: 230 KN--QLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELEN 287
N +L V++LQ+ +QL + + + ++ ++L+E+ + +EL N
Sbjct: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHN-DISAMQQQLQEKRE-----AVNSLQEELAN 1875
Query: 288 KKKELHFLQK-----------VVSEPAMGHSDLLELESKINEINTEINQLIEK-KMMRNE 335
+ L+ ++ ++SE D+ E ++ + E ++ ++++NE
Sbjct: 1876 VQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNE 1935
Query: 336 PIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQT 383
E KL L +Q+ +KE ++EE + K+ E++ +++ T
Sbjct: 1936 IEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELT 1983
Score = 39.3 bits (90), Expect = 0.007
Identities = 54/264 (20%), Positives = 121/264 (45%), Gaps = 18/264 (6%)
Query: 145 EELMEAFKTLHKEYEQLKISGFSTA----EIRKDISAMEEEKDQLIKRVEHLKKRVETAQ 200
E++M+ K+ +E ++ S + E+ +I + +EK L VE L + V+ Q
Sbjct: 1329 EDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQ 1388
Query: 201 NHQWMLK-IARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKP 259
+ + L E E E+ L + ++ +++ + L + +++L+ + A+A
Sbjct: 1389 QQKDFIDGNVESLMTELEIEKSL-KHHEDIVDEIECIEKTLLKRRSELREADRLLAEA-- 1445
Query: 260 ESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEI 319
ES + +E+ K + T+ + L + + L++ E A+ +L++ + ++ +
Sbjct: 1446 ESELSCTKEKTKNAVEKFTDA-KRSLLQTESDAEELERRAQETAV---NLVKADQQLRSL 1501
Query: 320 NTEINQLIEKKMMRNEPIEGKLSLYRQQAS---IISRKKEAKAEELQEAKEKLASLEREA 376
+ L + K+ + E ++ + + S +S+KKE EELQ+ ++ + ER
Sbjct: 1502 QADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNE 1561
Query: 377 SVKRNQTREFDGTEVLKGDERQDL 400
+E +EVL +R +L
Sbjct: 1562 DHHLQVLKE---SEVLLQAKRAEL 1582
Score = 36.6 bits (83), Expect = 0.045
Identities = 50/230 (21%), Positives = 103/230 (44%), Gaps = 24/230 (10%)
Query: 126 EVPSEFLQDETVADTNKQYEELMEAF-KTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQ 184
+V S+ L E T ++ E E+ KTL + QL E ++ A+++E D
Sbjct: 1991 QVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADS 2050
Query: 185 LIKRVEHLKKR--VETAQNHQWMLKIARQLRVEKER-EEYLAQQKQEQKNQLFHAVQRLQ 241
+ L+ + E + + + + L++++ + E+ L +QKQE
Sbjct: 2051 MRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSC---------- 2100
Query: 242 RVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSE 301
+Q ++ ++ A D + +RL +E+ Y TE K++ N+K +L Q +S+
Sbjct: 2101 -IQKEMATIELVAQDNHERA--RRLMKELNQMQYEYTE-LKKQMANQK-DLERRQMEISD 2155
Query: 302 PAMGHSDLL--ELESKINEINTEINQL---IEKKMMRNEPIEGKLSLYRQ 346
+ E+ + + +N + +L +E + RNE +EG+L ++
Sbjct: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKE 2205
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 53.1 bits (126), Expect = 5e-07
Identities = 47/226 (20%), Positives = 109/226 (48%), Gaps = 21/226 (9%)
Query: 126 EVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQL 185
++ ++ Q++ V +Q ++ ++ + L ++ EQL+ + + +++++QL
Sbjct: 176 QLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQL 235
Query: 186 --------IKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAV 237
+++ L++++ Q Q ++ Q + + +++ L QQ+Q Q+ Q
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQ---QQ 292
Query: 238 QRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQK 297
Q LQ+ Q QL+ + +PE EEE++ L V +ELE +++EL Q+
Sbjct: 293 QLLQQQQEQLQQQQLQPPPLEPEE-----EEEVELELMPVDLGSEQELEQQRQELERQQE 347
Query: 298 VVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
+ + + +L+ K+ E ++ Q +E++ + E E +L L
Sbjct: 348 LERQ-----QEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLEL 388
Score = 38.1 bits (87), Expect = 0.016
Identities = 60/301 (19%), Positives = 140/301 (46%), Gaps = 46/301 (15%)
Query: 132 LQDETVADTNKQYEELM-EAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVE 190
LQ + D +Q +L E +++H +++LK ++ ++ ++ Q +R++
Sbjct: 118 LQQQPQQDGQQQLSQLQQEKHQSVH--HQELK----PELQLMHQQQQLQPQQVQEQQRLQ 171
Query: 191 HLKKRVETAQ-NHQWMLKIARQLRVEKEREEYLAQQKQE--QKNQLFHAVQRLQ------ 241
+++++T Q Q +L+ QL+ ++ +E+ L QQ+QE Q+ QL ++LQ
Sbjct: 172 QQQEQLQTQQAQEQQVLQQQEQLQ-QQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQ 230
Query: 242 ------------------RVQNQLKSMRQAAADAK-PESLMKRLEEEIKFNLYMVTEKFP 282
++Q QL +QA + E +L++++ ++
Sbjct: 231 QQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQ 290
Query: 283 KELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLS 342
++ ++++ Q+ + P + + E+E ++ ++ Q +E+ + + +E +
Sbjct: 291 QQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQ---QRQELERQQE 347
Query: 343 LYRQQASIISRKKEAK-AEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQDLT 401
L RQQ R+ + K EELQ+ +++ LE++ Q + + T V G ++Q++
Sbjct: 348 LERQQE---QRQLQLKLQEELQQLEQQ---LEQQQQQLEQQEVQLELTPVELGAQQQEVQ 401
Query: 402 L 402
L
Sbjct: 402 L 402
Score = 34.3 bits (77), Expect = 0.22
Identities = 45/251 (17%), Positives = 111/251 (44%), Gaps = 26/251 (10%)
Query: 179 EEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKER---------EEYLAQQKQEQ 229
+ + +QL + HL+ + + Q+ Q L QL+ EK + E L Q+Q+
Sbjct: 103 QPQHEQLQQPQPHLELQQQPQQDGQQQLS---QLQQEKHQSVHHQELKPELQLMHQQQQL 159
Query: 230 KNQLFHAVQRLQRVQNQLKSMR-----------QAAADAKPESLMKRLEEEIKFN--LYM 276
+ Q QRLQ+ Q QL++ + Q + + L+++ +E+++ L
Sbjct: 160 QPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQ 219
Query: 277 VTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEP 336
+ ++ + ++++L Q+++ G L+ + ++ ++ + + ++ +
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLL 279
Query: 337 IEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDE 396
++ + L +QQ + ++++ + ++ Q+ + E E V+ G+E +
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQLQQ-QQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQ 338
Query: 397 RQDLTLSPRLE 407
RQ+L LE
Sbjct: 339 RQELERQQELE 349
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/250 (20%), Positives = 113/250 (45%), Gaps = 20/250 (8%)
Query: 135 ETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKK 194
E +Q E++ E + + K+ EQ+ G ++RK M E+++Q+ K+ E ++K
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQM---GEQEEQMRKQEEQMGEQEEQVQKQEEQVQK 252
Query: 195 RVETAQNHQWMLKIARQLRVEKEREEYLAQQKQ--EQKNQLFHAVQRLQRVQNQLKSMRQ 252
+ E + + ++ Q +E+EE + +QK+ EQ+ Q ++++ + Q++ +
Sbjct: 253 QEEQMRKQEEQMR--EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEE 310
Query: 253 AAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLEL 312
+ E M+ EE++ + E+ + E K+ Q E MG E
Sbjct: 311 QMRE--QEEQMREQEEQMGKQEEQMWEQKEQMWEQKE------QMWKQEEQMG-----EQ 357
Query: 313 ESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASL 372
E ++ + ++ + E+ + E + + R+Q + +KE E+ ++ +E+ +
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 373 EREASVKRNQ 382
+ R Q
Sbjct: 418 GEQKEQMRKQ 427
Score = 40.4 bits (93), Expect = 0.003
Identities = 30/146 (20%), Positives = 70/146 (47%), Gaps = 9/146 (6%)
Query: 133 QDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAME----EEKDQLIKR 188
Q E T +Q E++ E + + ++ EQ++ E + + E E+K+Q+ ++
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343
Query: 189 VEHL-KKRVETAQNHQWMLKIARQLRVEKE----REEYLAQQKQEQKNQLFHAVQRLQRV 243
E + K+ + + + M K Q+R ++E +EE + +Q+++ + Q ++ +++
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 244 QNQLKSMRQAAADAKPESLMKRLEEE 269
Q + MR+ + R +EE
Sbjct: 404 GEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 37.7 bits (86), Expect = 0.020
Identities = 28/128 (21%), Positives = 61/128 (47%), Gaps = 2/128 (1%)
Query: 133 QDETVADTNKQYEELMEAF-KTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEH 191
Q+E + + +Q E E K + +EQ + ++ K M E+++Q+ K+ E
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Query: 192 LKKRVETAQNHQ-WMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSM 250
++K+ E + + M K Q+R ++E+ +Q EQK Q+ +++ + Q++
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQ 427
Query: 251 RQAAADAK 258
+ + K
Sbjct: 428 EEHMGEQK 435
Score = 35.0 bits (79), Expect = 0.13
Identities = 22/111 (19%), Positives = 58/111 (52%), Gaps = 9/111 (8%)
Query: 142 KQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQN 201
+Q E++ E + + K+ EQ+ G +++K + ++++Q+ K+ E ++K+ E
Sbjct: 335 EQKEQMWEQKEQMWKQEEQM---GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ--- 388
Query: 202 HQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQ 252
M K Q+ +KE+ +Q +EQ+ Q+ +++++ + + ++
Sbjct: 389 ---MRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 34.3 bits (77), Expect = 0.22
Identities = 39/245 (15%), Positives = 109/245 (44%), Gaps = 18/245 (7%)
Query: 169 AEIRKDISAMEEEKDQLIKRVEHLKKRVET--------AQNHQWMLKIARQLRVEKEREE 220
AE+++++ +E EK ++ ++ LK+++ET Q + ++ Q +E+E
Sbjct: 14 AELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEG 73
Query: 221 YLAQQK---QEQKNQLFHAVQRLQRVQNQLKSM-----RQAAADAKPESLMKRLEEEIKF 272
+ +Q+ +EQ+ Q+ +++ + Q++ Q + E ++ E +++
Sbjct: 74 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 133
Query: 273 NLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMM 332
V E+ + E + + +V + ++ + ++ + Q+ E++
Sbjct: 134 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 193
Query: 333 RNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVL 392
E EG++ +Q + + + E++ E +E++ E + + Q ++ + +V
Sbjct: 194 MGEQ-EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE-EQVQ 251
Query: 393 KGDER 397
K +E+
Sbjct: 252 KQEEQ 256
Score = 33.9 bits (76), Expect = 0.29
Identities = 43/283 (15%), Positives = 118/283 (41%), Gaps = 10/283 (3%)
Query: 124 KLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAE----IRKDISAME 179
K+ +P E E +Q ++ E + ++ Q++ E +R+ +
Sbjct: 45 KIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 104
Query: 180 EEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQR 239
E++ Q+ R + + R + Q + ++ Q +E+E + +Q+ + + Q ++
Sbjct: 105 EQEGQV--REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 162
Query: 240 LQRVQNQLKSMRQAAADAKPESLMKRLEE----EIKFNLYMVTEKFPKELENKKKELHFL 295
+V+ Q +R+ + + R +E E + + E+ ++ E +K+ +
Sbjct: 163 EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM 222
Query: 296 QKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKK 355
+ + + E E ++ + ++ + E+ + E + + R+Q + ++K
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 356 EAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDERQ 398
E +E Q +++ E+E ++ + + + E ++ E Q
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,475,483
Number of Sequences: 37866
Number of extensions: 623095
Number of successful extensions: 6756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 835
Number of HSP's that attempted gapping in prelim test: 3727
Number of HSP's gapped (non-prelim): 2589
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.