Guide to the Human Genome
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Search of human proteins with 33946311

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
         (927 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ...  1862   0.0  
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ...  1851   0.0  
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ...  1845   0.0  
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ...  1809   0.0  
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),...  1326   0.0  
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),...  1317   0.0  
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),...  1317   0.0  
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ...  1315   0.0  
gi|57163987 solute carrier family 8 member 2 [Homo sapiens]          1305   0.0  
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),...   597   e-170
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ...   577   e-164
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]    80   7e-15
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    70   7e-12
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    70   7e-12
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho...    70   7e-12
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex...    69   2e-11
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs...    65   3e-10
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          65   4e-10
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e...    65   4e-10
gi|45504369 solute carrier family 24, member 5 [Homo sapiens]          64   5e-10
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa...    63   1e-09
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso...    63   1e-09
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso...    62   2e-09
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    61   6e-09
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]         52   3e-06
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]         52   3e-06
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]         52   3e-06
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]       41   0.005
gi|39995086 solute carrier family 24 member 6 [Homo sapiens]           34   0.55 
gi|223029420 SKI-like isoform 2 [Homo sapiens]                         33   0.94 

>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform C precursor [Homo sapiens]
          Length = 927

 Score = 1862 bits (4824), Expect = 0.0
 Identities = 927/927 (100%), Positives = 927/927 (100%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
           MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60

Query: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
           PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120

Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
           TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180

Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
           IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240

Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
           FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300

Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
           LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360

Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
           MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420

Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
           KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480

Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
           FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540

Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
           VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600

Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL 660
           KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL 660

Query: 661 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 720
           GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
Sbjct: 661 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 720

Query: 721 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 780
           EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
Sbjct: 721 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 780

Query: 781 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 840
           CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
Sbjct: 781 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 840

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 900
           SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
Sbjct: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 900

Query: 901 TTWLFVSLWLLYILFATLEAYCYIKGF 927
           TTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 901 TTWLFVSLWLLYILFATLEAYCYIKGF 927


>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform B precursor [Homo sapiens]
          Length = 924

 Score = 1851 bits (4795), Expect = 0.0
 Identities = 924/927 (99%), Positives = 924/927 (99%), Gaps = 3/927 (0%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
           MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60

Query: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
           PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120

Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
           TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180

Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
           IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240

Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
           FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300

Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
           LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360

Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
           MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420

Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
           KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480

Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
           FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540

Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
           VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600

Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL 660
           KIVDEEEYERQENFFIALGEPKWMERGISALLLSP   DRKLTMEEEEAKRIAEMGKPVL
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSP---DRKLTMEEEEAKRIAEMGKPVL 657

Query: 661 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 720
           GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
Sbjct: 658 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 717

Query: 721 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 780
           EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
Sbjct: 718 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 777

Query: 781 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 840
           CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
Sbjct: 778 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 837

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 900
           SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
Sbjct: 838 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 897

Query: 901 TTWLFVSLWLLYILFATLEAYCYIKGF 927
           TTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 898 TTWLFVSLWLLYILFATLEAYCYIKGF 924


>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform D precursor [Homo sapiens]
          Length = 921

 Score = 1845 bits (4780), Expect = 0.0
 Identities = 921/927 (99%), Positives = 921/927 (99%), Gaps = 6/927 (0%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
           MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60

Query: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
           PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120

Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
           TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180

Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
           IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240

Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
           FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300

Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
           LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360

Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
           MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420

Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
           KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480

Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
           FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540

Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
           VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600

Query: 601 KIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVL 660
           KIVDEEEYERQENFFIALGEPKWMERGIS      DVTDRKLTMEEEEAKRIAEMGKPVL
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGIS------DVTDRKLTMEEEEAKRIAEMGKPVL 654

Query: 661 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 720
           GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG
Sbjct: 655 GEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG 714

Query: 721 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 780
           EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG
Sbjct: 715 EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG 774

Query: 781 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 840
           CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW
Sbjct: 775 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAW 834

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 900
           SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA
Sbjct: 835 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLA 894

Query: 901 TTWLFVSLWLLYILFATLEAYCYIKGF 927
           TTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 895 TTWLFVSLWLLYILFATLEAYCYIKGF 921


>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform A precursor [Homo sapiens]
          Length = 925

 Score = 1809 bits (4686), Expect = 0.0
 Identities = 902/928 (97%), Positives = 913/928 (98%), Gaps = 4/928 (0%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
           MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1   MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60

Query: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
           PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61  PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120

Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
           TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180

Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
           IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240

Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
           FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300

Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
           LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360

Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
           MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420

Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
           KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480

Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
           FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540

Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
           VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600

Query: 601 KIVDEEEYERQENFFIALGEPKWMERGI-SALLLSPDVTDRKLTMEEEEAKRIAEMGKPV 659
           K++D+E YE+ +N+FI +  P+ ++     ALLLSP   DRKLTMEEEEAKRIAEMGKPV
Sbjct: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP---DRKLTMEEEEAKRIAEMGKPV 657

Query: 660 LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES 719
           LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES
Sbjct: 658 LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES 717

Query: 720 GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF 779
           GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF
Sbjct: 718 GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF 777

Query: 780 GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA 839
           GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA
Sbjct: 778 GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA 837

Query: 840 WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL 899
           WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL
Sbjct: 838 WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL 897

Query: 900 ATTWLFVSLWLLYILFATLEAYCYIKGF 927
           ATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 898 ATTWLFVSLWLLYILFATLEAYCYIKGF 925


>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform D [Homo sapiens]
          Length = 937

 Score = 1326 bits (3431), Expect = 0.0
 Identities = 673/942 (71%), Positives = 782/942 (83%), Gaps = 23/942 (2%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59

Query: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119

Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179

Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239

Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299

Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358

Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418

Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478

Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535

Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595

Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRK--LTME 645
           EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG+       D  D K  LT +
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655

Query: 646 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 705
           EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715

Query: 706 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 765
           ITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775

Query: 766 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 825
           G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835

Query: 826 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 885
           GSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895

Query: 886 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 927
            +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937


>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform C [Homo sapiens]
          Length = 960

 Score = 1317 bits (3409), Expect = 0.0
 Identities = 674/965 (69%), Positives = 785/965 (81%), Gaps = 46/965 (4%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59

Query: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119

Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179

Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239

Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299

Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358

Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418

Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478

Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535

Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595

Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
           EF+NDE VK I ++I D EEYE++ +F + L EPKW+ RG                    
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGQPVFRKVHARE 655

Query: 628 ---ISALLLSPDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDK 682
              +S ++   D  D K  LT +EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDK
Sbjct: 656 HPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDK 715

Query: 683 LIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVL 742
           LIKKTNLALVVGT+SWR+QF+EAITVSA  D+D+DE GEE+LPSCFDYVMHFLTVFWKVL
Sbjct: 716 LIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVL 775

Query: 743 FACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVP 802
           FA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVP
Sbjct: 776 FAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVP 835

Query: 803 DTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLA 862
           DTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A  G++F VS GTLA
Sbjct: 836 DTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLA 895

Query: 863 FSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYC 922
           FSVTLFTIFAF+ + VLLYRRRP +GGELGGPR  KL T+ LFV LWLLYI F++LEAYC
Sbjct: 896 FSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYC 955

Query: 923 YIKGF 927
           +IKGF
Sbjct: 956 HIKGF 960


>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform B [Homo sapiens]
          Length = 968

 Score = 1317 bits (3408), Expect = 0.0
 Identities = 674/973 (69%), Positives = 787/973 (80%), Gaps = 54/973 (5%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59

Query: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119

Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179

Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239

Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299

Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358

Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418

Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478

Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535

Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595

Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
           EF+NDE VKTI VK++D+EEYE+ + FF+ +GEP+ +E                      
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPV 655

Query: 628 -----------ISALLLSPDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESY 674
                      +S ++   D  D K  LT +EEE +RIAEMG+P+LGEH KLEVIIEESY
Sbjct: 656 FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY 715

Query: 675 EFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHF 734
           EFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA  D+D+DE GEE+LPSCFDYVMHF
Sbjct: 716 EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF 775

Query: 735 LTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVF 794
           LTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVF
Sbjct: 776 LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF 835

Query: 795 VAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEF 854
           VA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A  G++F
Sbjct: 836 VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF 895

Query: 855 HVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYIL 914
            VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR  KL T+ LFV LWLLYI 
Sbjct: 896 KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF 955

Query: 915 FATLEAYCYIKGF 927
           F++LEAYC+IKGF
Sbjct: 956 FSSLEAYCHIKGF 968


>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform A [Homo sapiens]
          Length = 973

 Score = 1315 bits (3403), Expect = 0.0
 Identities = 674/978 (68%), Positives = 787/978 (80%), Gaps = 59/978 (6%)

Query: 1   MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
           M  L L P  S   H  +   +LF  ++ + AE    G+   TG+    C+GS  CK+GV
Sbjct: 4   MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59

Query: 59  ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
           ILPIW P++PS GDKIAR  VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60  ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119

Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
           GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179

Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
           FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT 
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239

Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
           FFFP+CV+ AWVAD+RLLFYKY++K+YR  K RG+IIE EGD P     IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299

Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
              FLDG LV LE  E D    E+RREM RILK+LKQKHP+K+++QL+E+ANY  LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358

Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
           KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+  E D +SK+FF+  +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418

Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
           LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE  VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478

Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
           IIDDDIFEEDE+F V LSNV++  E  E+G+  A   S     A L SP  ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535

Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
           HAGIFTFE    HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595

Query: 588 EFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERG-------------------- 627
           EF+NDE VKTI VK++D+EEYE+ + FF+ +GEP+ +E                      
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYL 655

Query: 628 ----------------ISALLLSPDVTDRK--LTMEEEEAKRIAEMGKPVLGEHPKLEVI 669
                           +S ++   D  D K  LT +EEE +RIAEMG+P+LGEH KLEVI
Sbjct: 656 FGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVI 715

Query: 670 IEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFD 729
           IEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA  D+D+DE GEE+LPSCFD
Sbjct: 716 IEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFD 775

Query: 730 YVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSV 789
           YVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSV
Sbjct: 776 YVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSV 835

Query: 790 TAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAL 849
           TAVVFVA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A 
Sbjct: 836 TAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAA 895

Query: 850 QGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLW 909
            G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR  KL T+ LFV LW
Sbjct: 896 NGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLW 955

Query: 910 LLYILFATLEAYCYIKGF 927
           LLYI F++LEAYC+IKGF
Sbjct: 956 LLYIFFSSLEAYCHIKGF 973


>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
          Length = 921

 Score = 1305 bits (3377), Expect = 0.0
 Identities = 639/891 (71%), Positives = 763/891 (85%), Gaps = 23/891 (2%)

Query: 48  CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
           C GS  C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 43  CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102

Query: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
           +E+E+TI K NGETS  T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162

Query: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
            TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222

Query: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
           VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD   GIII  EGD PK IE+
Sbjct: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282

Query: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
           DG  + +    G L      P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341

Query: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
           AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+       DE +D  S++FF+P
Sbjct: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400

Query: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
             Y CLENCG+VLL+V  +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460

Query: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
           E  +GIIDDDIFEEDEHFFVRL N+R+ + Q    P+ G           P+  L +P +
Sbjct: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511

Query: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
           ATVTILDDDHAGIF+F+   +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG 
Sbjct: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571

Query: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVT 638
            +ED  GELEF +DET+KT++VKIVD+EEYE+++NFFI LG+P+W++RGISALLL+    
Sbjct: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631

Query: 639 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 698
           DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSW
Sbjct: 632 DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSW 691

Query: 699 RDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 756
           R+QF+EAITVS AGDE+E+E G  EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA
Sbjct: 692 REQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750

Query: 757 CFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVY 816
           CF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD  
Sbjct: 751 CFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQC 810

Query: 817 ADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 876
           ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V  GTLAFSVTLFT+FAFV I
Sbjct: 811 ADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI 870

Query: 877 SVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 927
           +VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 871 AVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921


>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform G [Homo sapiens]
          Length = 298

 Score =  597 bits (1539), Expect = e-170
 Identities = 298/304 (98%), Positives = 298/304 (98%), Gaps = 6/304 (1%)

Query: 624 MERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKL 683
           MERGIS      DVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKL
Sbjct: 1   MERGIS------DVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKL 54

Query: 684 IKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLF 743
           IKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLF
Sbjct: 55  IKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLF 114

Query: 744 ACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPD 803
           ACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPD
Sbjct: 115 ACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPD 174

Query: 804 TFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAF 863
           TFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAF
Sbjct: 175 TFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAF 234

Query: 864 SVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 923
           SVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY
Sbjct: 235 SVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 294

Query: 924 IKGF 927
           IKGF
Sbjct: 295 IKGF 298


>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
           member 3 isoform F [Homo sapiens]
          Length = 284

 Score =  577 bits (1487), Expect = e-164
 Identities = 284/284 (100%), Positives = 284/284 (100%)

Query: 644 MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 703
           MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM
Sbjct: 1   MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 60

Query: 704 EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 763
           EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL
Sbjct: 61  EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 120

Query: 764 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 823
           IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN
Sbjct: 121 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 180

Query: 824 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 883
           VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR
Sbjct: 181 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 240

Query: 884 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 927
           RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 241 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 284


>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
          Length = 6306

 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 35/282 (12%)

Query: 349  KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
            + ++FY  Q T +  G           ++   ++++ V +D P     +  F     +  
Sbjct: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279

Query: 409  ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
            E    V +T++R  GD      + YKT  G+A AG D+    G ++ + GE +K   V I
Sbjct: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337

Query: 469  IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
            +DDD  E  E F + ++ V          I+E   +   PP I N             + 
Sbjct: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386

Query: 520  TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
             + I+ +D+A GI  F+       V E +G++ + V+R  G  G V   F +   +A  G
Sbjct: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446

Query: 577  GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
            G D+      + F++ + +  I + I+D+ E E +E   I L
Sbjct: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 19/190 (10%)

Query: 437  DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
            D  A    DY   E  +++K    +    V I+ DD+ E +E F V ++ V +       
Sbjct: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886

Query: 497  GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECD--------TIHVSESIGVM 548
            G P     S+  P   +A   +      +DD  GIF F              V   + V+
Sbjct: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937

Query: 549  EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
            +V V+R +G+ G V V ++    +A  G EDF+ ++G LEF + +    I + I+D+ E+
Sbjct: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995

Query: 609  ERQENFFIAL 618
            E  E F I+L
Sbjct: 3996 ELTETFNISL 4005



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 24/193 (12%)

Query: 438  GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
            G A AG+DYE  T    +++ G+     +V I+ DD  E DE F + L  V +       
Sbjct: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554

Query: 497  GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
               P I             P ++TV I L+ D  G+F     + + SE    +EV+    
Sbjct: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603

Query: 552  ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
                  + RT G+ G V V +R V GTA   G DF      L F   ET KT+ + I+D+
Sbjct: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662

Query: 606  EEYERQENFFIAL 618
             E E  E+  ++L
Sbjct: 2663 SEPEDDESIIVSL 2675



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 28/221 (12%)

Query: 414  VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
            + L+++R  G M K + V Y T D              A  G DY    G  +    +++
Sbjct: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055

Query: 462  KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
               ++ I+DDD  E  E  F+ L N  +           A   S  +P +    P V T+
Sbjct: 2056 ATIAISILDDDEPERSESVFIELLNSTL----------VAKVQSRSIPNSPRLGPKVETI 2105

Query: 522  T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
                 I +DD  G        + V+E+     + V RT GA   V V F+ V  TA   G
Sbjct: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164

Query: 578  EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
            ED+     ++     ET K + + ++++   E +E+F + L
Sbjct: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (13%)

Query: 405  YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
            ++  E  G++ L   R    +       Y  ++  A  G DY FT   +    GE  K  
Sbjct: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027

Query: 465  SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
            ++ I+DDDI E DE F + L+N                    P P   L    +A + +L
Sbjct: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067

Query: 525  -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
             +DD  G+ +F         E   ++V ES+ V+ +      G  GTV V F   E  + 
Sbjct: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127

Query: 575  GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
               +D   + G +  +     K +++  + + E E  E F   L  P
Sbjct: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 59/210 (28%), Positives = 83/210 (39%), Gaps = 29/210 (13%)

Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
           + L + R G   + T  V    ED       D+  T     +  GET +   + + DDD+
Sbjct: 51  IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105

Query: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
            E DE F   L+  +                  P     L  P   TVTIL +D+A GI 
Sbjct: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147

Query: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
           +F    +I VSE  G    M + ++R  G  G V+V F  VEG      ED     G + 
Sbjct: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206

Query: 589 FKNDETVKTIRVKIVDEEEYERQENFFIAL 618
           F          + ++D+E  E  E F I L
Sbjct: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL 236



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 20/224 (8%)

Query: 409  ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
            E  G + L V+R  G + +    +++T   +A +  DY+   GT+  +PGE  K   + I
Sbjct: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792

Query: 469  IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
             D+ I E ++ F V L N+        R++     +G     F      RA L       
Sbjct: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851

Query: 521  VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
            VTI   DHA G+F F  +++ VS     +    + + V+R  G    V + +  ++    
Sbjct: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910

Query: 575  GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
            G   D   T G + F+  +T   I V+I+ +E+ E  + F +++
Sbjct: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 43/221 (19%)

Query: 414  VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
            V L V+R  G +S  T++ +  ++ DG      D  FT G +  + G+T    +V I+ D
Sbjct: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938

Query: 472  DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
            +  E D+ F V +                     L +    L +   AT+T+L  DD  G
Sbjct: 1939 EDPELDKAFSVSV---------------------LSVSSGSLGAHINATLTVLASDDPYG 1977

Query: 531  IFTF--ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK-----------GGG 577
            IF F  +   + V E+   + + ++R  G  G V+V + T++   K             G
Sbjct: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037

Query: 578  EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
             D+    G   F  +++  TI + I+D++E ER E+ FI L
Sbjct: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 27/209 (12%)

Query: 409  ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
            EN    ++ V R GG  +    V +K    +A AG DY      VVL  GET K   + +
Sbjct: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189

Query: 469  IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
            I+D   E +E F V+L N         E    A   +  L  AV+       +    DD 
Sbjct: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231

Query: 529  AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
             G+F F+   + V E    S+ V  + ++R SG  G V V +  T+ G    G  D    
Sbjct: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288

Query: 584  YGELEFKNDETVKTIRVKIVDEEEYERQE 612
             G + F   ET++T+ ++++ ++  E +E
Sbjct: 2289 SGNVTFAPGETIQTLLLEVLADDVPEIEE 2317



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 65/242 (26%), Positives = 95/242 (39%), Gaps = 32/242 (13%)

Query: 399  FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
            F   C  +  E    +   V R  G  D     Y   + E DG      D+    GT+  
Sbjct: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636

Query: 456  KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
             P +  +  ++ ++DDDI E +E+F V L +       P +G       S P   A +  
Sbjct: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687

Query: 516  PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
                T +TI   DH  G+  F                     I V E  G + + V+R  
Sbjct: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747

Query: 557  GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFI 616
            G  G V   FRTV  TA    ED+++  G LEF+  E  K I + I D    E +++F +
Sbjct: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806

Query: 617  AL 618
             L
Sbjct: 1807 EL 1808



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 22/184 (11%)

Query: 445  DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFN 504
            ++  T G + ++  ++     +  ++DDI EE   +  +L+ V       E G+      
Sbjct: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVS------EGGV------ 4247

Query: 505  SLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVSESIGVMEVKVLRTSGARGTVI 563
                   +  S   A +T++  D   G F F  + + VSE+  V  + ++R+SG  G V 
Sbjct: 4248 -------LSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQRV-NITIIRSSGDFGHVR 4299

Query: 564  VPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKW 623
            + ++T+ GTA+ G  DF    GEL F+  E  K++ V+I+D++  E  E F + + + + 
Sbjct: 4300 LWYKTMSGTAEAG-LDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358

Query: 624  MERG 627
              RG
Sbjct: 4359 QGRG 4362



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 15/210 (7%)

Query: 412  GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
            GA+ +T     G +S    +  +T    A    D+    G ++L+ GET    ++ I++D
Sbjct: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911

Query: 472  DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
            D+ E +E+F V L+ V         G+  A   S P PR          +   +D   G+
Sbjct: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961

Query: 532  FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
              ++     V+E+ G + +   R+    G V + F   +      G D+  T   L F +
Sbjct: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020

Query: 592  DETVKTIRVKIVDEEEYERQENFFIALGEP 621
             E  K + + I+D++  E  E F + L  P
Sbjct: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 57/205 (27%), Positives = 90/205 (43%), Gaps = 26/205 (12%)

Query: 419  VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
            V + G +  T  V Y T+DG A A   D+   E   T++ + G  Q+  S+ + +D I E
Sbjct: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083

Query: 476  EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
             DE F++ L N   +    + G                    VATV I  +DD  GIF+ 
Sbjct: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123

Query: 535  ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
            E     V E        +LR  G  G+V V ++  +  +A   G++F +T G + F + E
Sbjct: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182

Query: 594  TVKTIRVKIVDEEEYERQENFFIAL 618
              K I +    ++  E  E +F+ L
Sbjct: 1183 EAKPIILHAFPDKIPEFNEFYFLKL 1207



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 46/180 (25%), Positives = 80/180 (44%), Gaps = 30/180 (16%)

Query: 444  ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
            +D+  + G ++ +PGE +   +V I+DD + E++E F V+L N       P+ G    I 
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637

Query: 504  NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
            +S+             T+TIL +D A GI  F  ++++      E   ++ + V R  G 
Sbjct: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684

Query: 559  RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
             G +     T+   A G   D   T G + F   + + TI + I+ +   E  E   + L
Sbjct: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 51/206 (24%), Positives = 90/206 (43%), Gaps = 23/206 (11%)

Query: 414  VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
            V L + R GG + +   V+++   G+A  G D+      +    GET+K   + I+DD  
Sbjct: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664

Query: 474  FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
             E+DE   V L          E G            R + +S  V    + +D+ AGI +
Sbjct: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706

Query: 534  FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
            F+  +  V    G +++  V+RT   RG V V ++ +    +    +F +  G+L F   
Sbjct: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763

Query: 593  ETVKTIRVKIVDEEEYERQENFFIAL 618
                T+ V ++D+   E +E + + L
Sbjct: 2764 SLNTTLFVHLLDDNIPEEKEVYQVIL 2789



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)

Query: 409  ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
            E+   + L V R  G  S  + V Y+T  GSA    D+E  + G +  +  +T+ +F + 
Sbjct: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077

Query: 468  IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
            II+D + E +E F++ L++V I   Q         F+    PR  L    VA +TILD D
Sbjct: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128

Query: 527  DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
            D AG+  +F   T+ V+    ++ V+   T+
Sbjct: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 27/138 (19%)

Query: 511  AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
            AV   P VATVT     H G F+     +++ E +        EV + RT G  G V + 
Sbjct: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258

Query: 565  ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD 604
                            PFR + G    T     EDFE+    L F + E  + + V+I+D
Sbjct: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318

Query: 605  EEEYERQENFFIALGEPK 622
            ++E E QE F++ L  P+
Sbjct: 5319 DDEPEGQEFFYVFLTNPQ 5336



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 76/317 (23%), Positives = 119/317 (37%), Gaps = 54/317 (17%)

Query: 400  FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
            FDP   +++  E+ G +++ VVR  G        D+ ++  SA+  G DY     TV  +
Sbjct: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460

Query: 457  PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
             G+     ++ IIDD+  E +E   + L+                         AVL   
Sbjct: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500

Query: 517  CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
             V+ + I   D   G+  F      +I    S  ++ + + RT G  G + V + TV   
Sbjct: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560

Query: 573  AKGG----GEDFEDTYGELEF--KNDETVKTIRVKIVDEEEYERQENFFIAL----GEPK 622
            ++        D  D    L +  + +  V+TI + I   EE E +E F I L    GE K
Sbjct: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620

Query: 623  WMERGISALL-------------LSPDVTDRKLTMEE---EEAKRIAEMGKPVLGEHPKL 666
               R     L              +P+   +K   E    E    I    + V G   ++
Sbjct: 4621 LDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEI 4680

Query: 667  EVIIEESYEFKTTVDKL 683
             V  E S EF  T D L
Sbjct: 4681 MVYWELSSEFDITEDFL 4697



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 33/222 (14%)

Query: 404  SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
            +Y+       + + VVR  G     + V +K    SA    D++ + G +     +    
Sbjct: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984

Query: 464  FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
              + IIDD  FE  E F + L +V                         L    V TV I
Sbjct: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024

Query: 524  LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
              +D   G+F FE  T+ + ES+        + + V+R+ G +GTV + + T++  AK  
Sbjct: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081

Query: 577  GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
              +     G L F   E+ KTI +  + +   E    F I L
Sbjct: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQL 4122



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 53/213 (24%), Positives = 87/213 (40%), Gaps = 34/213 (15%)

Query: 413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDD 472
           +V L ++R  G + K  ++ Y+ E   +N   ++    G +  KPGE +   ++    D 
Sbjct: 793 SVELHIIRSRGSLVK-QFLHYRVEPRDSN---EFYGNTGVLEFKPGEREIVITLLARLDG 848

Query: 473 IFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGI 531
           I E DEH++V LS+    E +                   L S  +  +TIL +DD  GI
Sbjct: 849 IPELDEHYWVVLSSHGERESK-------------------LGSATIVNITILKNDDPHGI 889

Query: 532 FTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYG 585
             F  D + V       ++I      V+R  G  G V V +      +    +D     G
Sbjct: 890 IEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSVSW----VVSPDFTQDVFPVQG 945

Query: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
            + F + E  K I +  + +E  E  E F + L
Sbjct: 946 TVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)

Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
           LT++R+ G     M V ++ E G      D    +G +   PG     +++ ++DD++ E
Sbjct: 169 LTLIREKGTYGMVM-VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPE 227

Query: 476 EDEHFFVRLSNV 487
            DE F ++L +V
Sbjct: 228 NDEIFLIQLKSV 239



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 53/222 (23%), Positives = 88/222 (39%), Gaps = 39/222 (17%)

Query: 442  AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
            A +D     G +  + GET K F +   DD+  E +E F ++L +V    RI EE     
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558

Query: 498  MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
                                 A +TI   D+A G+F F    I  ++E    +   V RT
Sbjct: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599

Query: 556  SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQ 611
             GA   V V F T+      G     +DF +  G + F   +  + + + ++D++  E  
Sbjct: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658

Query: 612  ENFFIAL-----GEPKWMERGISALLLSPDVTDRKLTMEEEE 648
            E F + L     G+ K      S   + P+     +T++  +
Sbjct: 1659 EYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASD 1700



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 56/252 (22%), Positives = 91/252 (36%), Gaps = 46/252 (18%)

Query: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
           D P  F+  ++  P      E    +++ VVR     G  +    Y   + Y    G++ 
Sbjct: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313

Query: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
           A A             TVV  P   +      I+DD I E  E F + L    ++ +   
Sbjct: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370

Query: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
                          AVL SP V  VTI  +D   G+ +F       T+ + E       
Sbjct: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415

Query: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
           E+ V+R  G  G V   +     +        D   + G L F   + + TI + +VD++
Sbjct: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475

Query: 607 EYERQENFFIAL 618
             E  E + + +
Sbjct: 476 LPEEAEAYLLQI 487



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 55/236 (23%), Positives = 95/236 (40%), Gaps = 46/236 (19%)

Query: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
           EPEDF ++V + P                 R G D   T+Y   K    ++ A    D  
Sbjct: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708

Query: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
              G+V+   G++    ++ I  DDI E +E   + L  V +E +  + G     + S  
Sbjct: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763

Query: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
           L            + + +DD  G+F F   +     I   ES+   E+ ++R   +RG++
Sbjct: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805

Query: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
           +  F       +   E + +T G LEFK  E    I +    +   E  E++++ L
Sbjct: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWVVL 860



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)

Query: 530  GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
            G+F F   +  I VSE   ++ + V R  G    +I V ++T  G+AK   EDFE    G
Sbjct: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061

Query: 586  ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
            EL F+  +T     + I++++  E +E F+I L
Sbjct: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)

Query: 445  DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
            D+E    T++   GE +++ SV I+DDD  E  E F+V L+N     +I EE+ + G
Sbjct: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 31/233 (13%)

Query: 391  PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
            PE    K + +P + +     G +L+T  V R  G   + M   Y       +   D+  
Sbjct: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698

Query: 449  TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
            T G   +  GE++  F V ++ D++ E +E + ++L +V    E             L L
Sbjct: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745

Query: 509  PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
             +++      A     +DD  G+F    D  +I + ++ I  +++ + R +G  G V V 
Sbjct: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800

Query: 566  FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
             R +    K      E+   +L  K+  T K   V I ++       NF + L
Sbjct: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQL 4852



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 18/44 (40%), Positives = 26/44 (59%)

Query: 579  DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
            DF  + GEL F+  E   TI V I+D+   E++E+F + L  PK
Sbjct: 3586 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 12/97 (12%)

Query: 401  DPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGET 460
            DP SY        V LTVVR  G    T+ +++  ++    A  +     GT+     E+
Sbjct: 4051 DPDSY--------VTLTVVRSPGGKG-TVRLEWTIDE---KAKHNLSPLNGTLHFDETES 4098

Query: 461  QKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEG 497
            QK   +  + D + EED  F ++L ++   E  P +G
Sbjct: 4099 QKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)

Query: 410  NCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGII 469
            N   V L ++R  G +         T +G    G D     G V   PGET +   + ++
Sbjct: 2250 NSVKVNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVTFAPGETIQTLLLEVL 2308

Query: 470  DDDIFEEDEHFFVRLSN 486
             DD+ E +E   V+L++
Sbjct: 2309 ADDVPEIEEVIQVQLTD 2325


>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)

Query: 405  YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
            Y  ++     L   + + G + +T ++   T+D +A    D+++ T   +   PG+T   
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840

Query: 464  FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
            + V II D+ +E  E F + LS                     PL  AVL  P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879

Query: 524  LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
            +D  D + ++  E +   + E IG + + V R+  A   +IV   T +G+A G       
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938

Query: 577  GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
              D+    ED    L F  +ET KT +V I+D+  YE +E+F ++L  P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 400  FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
            F    Y   E+   V + V R+G D+S+   +     K+E  SA AG DY      +   
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074

Query: 457  PGETQKEFSVGIIDD 471
            PG   + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089


>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)

Query: 405  YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
            Y  ++     L   + + G + +T ++   T+D +A    D+++ T   +   PG+T   
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840

Query: 464  FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
            + V II D+ +E  E F + LS                     PL  AVL  P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879

Query: 524  LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
            +D  D + ++  E +   + E IG + + V R+  A   +IV   T +G+A G       
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938

Query: 577  GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
              D+    ED    L F  +ET KT +V I+D+  YE +E+F ++L  P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 400  FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
            F    Y   E+   V + V R+G D+S+   +     K+E  SA AG DY      +   
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074

Query: 457  PGETQKEFSVGIIDD 471
            PG   + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089


>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
            sapiens]
          Length = 2139

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)

Query: 405  YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
            Y  ++     L   + + G + +T ++   T+D +A    D+++ T   +   PG+T   
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840

Query: 464  FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
            + V II D+ +E  E F + LS                     PL  AVL  P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879

Query: 524  LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
            +D  D + ++  E +   + E IG + + V R+  A   +IV   T +G+A G       
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938

Query: 577  GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
              D+    ED    L F  +ET KT +V I+D+  YE +E+F ++L  P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)

Query: 400  FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
            F    Y   E+   V + V R+G D+S+   +     K+E  SA AG DY      +   
Sbjct: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074

Query: 457  PGETQKEFSVGIIDD 471
            PG   + F V I+DD
Sbjct: 2075 PGVRMQTFQVTILDD 2089


>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 2 [Homo sapiens]
          Length = 661

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)

Query: 77  VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
           +I++ + +IYMF+ ++I+ D F      + +++  ++                 + V+  
Sbjct: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177

Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
           T MA G SAPE+  SLI V    FIA  ++G  TIVGSA FN+  +IG+C        +R
Sbjct: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228

Query: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
           +I +L        W +F  +  Y     M++  F   V+  WE LL L
Sbjct: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)

Query: 713 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 766
           DE+ED+      PS     + FL VF      W  L     P+        F  SI  I 
Sbjct: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511

Query: 767 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 826
           + + ++   A   G TIG+ + +  +  +A GTS+PD   S   A + +  D ++ +  G
Sbjct: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570

Query: 827 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 884
           SN  ++ +G+ L W +  +    Q      S G     V LF +  FV +S+ L + R
Sbjct: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)

Query: 783 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 838
           +G+ D V    F+A G S P+ F S        +++  IG + GS   N+   IG+
Sbjct: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)

Query: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
           +E +  LT++A G+S P+++ S+I V   G   GD+  S+ VGS  F++ +
Sbjct: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578


>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
            [Homo sapiens]
          Length = 3169

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 33/229 (14%)

Query: 405  YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
            Y  +      L  V+++ G + +T ++   T D +A    D++   +  V   PG+T+  
Sbjct: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836

Query: 464  FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
            + V I+ D   E+ E F V LS              P +        A L  P VATV I
Sbjct: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875

Query: 524  LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
            +D               V E +G + + + R+      ++V   T +GTA G        
Sbjct: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935

Query: 577  GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
              D+    ED    + F  DE  K  R+ I+D+  YE +E F + L  P
Sbjct: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 62/253 (24%), Positives = 104/253 (41%), Gaps = 32/253 (12%)

Query: 375  EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
            E +K   S+++  +D P     K+ F    Y   E+ G ++ T++ + GD+     V   
Sbjct: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165

Query: 435  TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
            T  GSA    D+E    T    +   PGET+K   + ++DD ++EE E        +R+ 
Sbjct: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218

Query: 491  EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
               P+   P           A +       + I DD    +  F      V+E       
Sbjct: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269

Query: 546  GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
             V+ + V+R        IV   T +G+A  G ED+     E+EFK  ET   + +++  +
Sbjct: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328

Query: 606  EEYERQENFFIAL 618
               E +E F + L
Sbjct: 2329 GVREMREAFTVHL 2341



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 63/233 (27%), Positives = 97/233 (41%), Gaps = 42/233 (18%)

Query: 389  DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
            DEP      VF     Y   E+ G + + + R+ GD+S+ + V   T+ G+A        
Sbjct: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933

Query: 442  -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
             + +DY    E     V     E +K   + IIDD ++EE+E F V L            
Sbjct: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981

Query: 497  GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
                    S+P+   + +    A VTI+ D D   IF F      V ES G +EV+V RT
Sbjct: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033

Query: 556  S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
                    +V V  R  +  +   G D+      L+F     ++ +RV I+D+
Sbjct: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 27/232 (11%)

Query: 399  FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
            +F    Y   E+ G V + V R G D+SK+  V     KT+  SA+AG DY      +  
Sbjct: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070

Query: 456  KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
             PG   +   V I+DD            L    +E  +  E     +   +P+  A L  
Sbjct: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112

Query: 516  PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
            P  ATV+I D         F+      SES G +   + RT   +    V   T +G+A+
Sbjct: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172

Query: 575  GGGEDFEDTYGE----LEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
                DFE+        + F   ET K   ++++D+  YE  E   + LG P+
Sbjct: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 9/85 (10%)

Query: 414  VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
            + + V+R+G D SK   V   T+DGSA +G DY      +  K GETQ    + +  D +
Sbjct: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330

Query: 474  FEEDEHFFVRLSNVRIEEEQPEEGM 498
             E  E F V L        +P+E M
Sbjct: 2331 REMREAFTVHL--------KPDENM 2347



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 23/89 (25%), Positives = 43/89 (48%)

Query: 533  TFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
            +FE +   V+E    ++V + R      T  +   T + TA+   +       +++F   
Sbjct: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831

Query: 593  ETVKTIRVKIVDEEEYERQENFFIALGEP 621
            +T  T RV+I+ + E+E+ E F + L EP
Sbjct: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEP 1860


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 69/245 (28%), Positives = 99/245 (40%), Gaps = 42/245 (17%)

Query: 396  SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA---------DY 446
            S + F   SY   E  G+V +TV R G ++++   V  +TE G+A++ +         DY
Sbjct: 2552 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSRVSSQPGQQDY 2610

Query: 447  EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSL 506
                G V     E  K  ++ I DDD+FE  E F V LS            MP       
Sbjct: 2611 VEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELS------------MP------- 2651

Query: 507  PLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF 566
                A+L     A V I D +      F+     V+ES G +   + R   A   V    
Sbjct: 2652 --AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAIC 2709

Query: 567  RTVEGTAKG-------GGEDFE----DTYGELEFKNDETVKTIRVKIVDEEEYERQENFF 615
             TV  +A G        G DF+         + F    T+ T  V ++D+ EYE +E F 
Sbjct: 2710 YTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFE 2769

Query: 616  IALGE 620
            IAL +
Sbjct: 2770 IALAD 2774



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 32/245 (13%)

Query: 414  VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGII 469
            VL   + + GD+S    V   T+  SA    D+E  +      +    G+  K  +V I 
Sbjct: 2935 VLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIH 2994

Query: 470  DDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA 529
            DD +FE +E F V L            G+P     S     A +    +AT+TI +D+ A
Sbjct: 2995 DDSMFEPEEQFRVYL------------GLPLGNHWS----GARIGKNNMATITISNDEDA 3038

Query: 530  GIFTFECDTIHVSE-----SIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTY 584
                FE     V E     +I ++ +KV+R      T  V   T +G+A+  G D+    
Sbjct: 3039 PTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKS 3097

Query: 585  GELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTM 644
              L+F         +V+I+  E+ E  E+F + LG    +E  +       DVT   +T+
Sbjct: 3098 RVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLG------DVTTATVTI 3151

Query: 645  EEEEA 649
             ++EA
Sbjct: 3152 LDQEA 3156



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 36/137 (26%), Positives = 62/137 (45%), Gaps = 16/137 (11%)

Query: 531  IFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG--------GGEDFED 582
            + +F+  + +VSE  G + V V RT       IV  RT +GTA          G +D+ +
Sbjct: 2553 LISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVE 2612

Query: 583  TYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKL 642
              G+++F   E  K+  + I D++ +E  E+F + L  P        A  L  + T  K+
Sbjct: 2613 YAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELSMP--------AYALLGEFTQAKV 2664

Query: 643  TMEEEEAKRIAEMGKPV 659
             + + E +   E  K +
Sbjct: 2665 IINDTEDEPTLEFDKKI 2681



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 24/154 (15%)

Query: 381  SSMSEVHTDEPEDFISKVFFDPCSYQCLENCG----AVLLTVVRKGGDMSKTMYVDYKTE 436
            ++M+ +     ED    + F+  +YQ  E  G    A+L   V + GD ++T  V   T 
Sbjct: 3025 NNMATITISNDED-APTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTR 3083

Query: 437  DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
            DGSA +G DY      +   PG     F V I+ ++  E  E F + L       + P E
Sbjct: 3084 DGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG-----PDDPVE 3138

Query: 497  GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAG 530
                          AVL     ATVTILD + AG
Sbjct: 3139 --------------AVLGDVTTATVTILDQEAAG 3158



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 62/237 (26%), Positives = 92/237 (38%), Gaps = 33/237 (13%)

Query: 396  SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKT---EDGSANAGADYEFTEGT 452
            S V     ++   E+ G V + V+R G D+S    V   T   +  SA  G DY  +   
Sbjct: 2798 STVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRK 2857

Query: 453  VVLKPGETQKEFSVGIIDD---DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLP 509
            V   PG  ++  ++ I+DD    + E  E F V LS+ +                     
Sbjct: 2858 VEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQ--------------------- 2896

Query: 510  RAVLASPCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRT 568
             A L  P  A + I D         F  D + V E  GV+ V + R+        V   T
Sbjct: 2897 GAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYT 2956

Query: 569  VEGTAKGGGEDFEDTY----GELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
               +A+   EDFE+        + F   + VK   V I D+  +E +E F + LG P
Sbjct: 2957 QSHSAQ-VMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLP 3012


>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 3 [Homo sapiens]
          Length = 644

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)

Query: 713 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 760
           +E+EDE  +E   + FD     L TV W        VL+  VP    P         FA 
Sbjct: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482

Query: 761 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 820
           S L I   + ++  + +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  D +
Sbjct: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541

Query: 821 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 876
           + N  GSN  ++ +G+GL W++  +     G    +++  L +SV L     FV +
Sbjct: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 41/110 (37%), Positives = 58/110 (52%), Gaps = 22/110 (20%)

Query: 77  VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
           V+++ +  IYMF  ++I+ D F                  P+ E     + + +E V+  
Sbjct: 110 VVLHVLCAIYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 152

Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
           T MA GSSAPE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C
Sbjct: 153 TFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)

Query: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 839
           L + V    F+A G+S P+ F S    +     D  +G + GS   N+   IG+      
Sbjct: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203

Query: 840 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 868
             VA   W L     + +   +A  V ++
Sbjct: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ I +G+
Sbjct: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559


>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
          Length = 500

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)

Query: 77  VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
           +I+YF+ ++YMF+ +SI+ D  F+ S+E+I+                       ++ V+ 
Sbjct: 69  IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110

Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
            T MA GSSAPE++ + + V    FI  GD+G STI+GSA +N   ++GIC    +    
Sbjct: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163

Query: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
              +    +F   AA++I A      +L +     V  +EG L L  + + VL+
Sbjct: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)

Query: 738 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 797
           FWK  F              F +S + I   T I+  + +  G T+ + D+V  +  +A 
Sbjct: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377

Query: 798 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 846
           GTS+PDT AS   A +    D ++ N+ GSN  ++ L +G+ W +   +
Sbjct: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)

Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
           +TV  LTL+A G+S P+ + S++ V   G   GD+  S IVGS  F+M  +
Sbjct: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414


>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
           sapiens]
          Length = 558

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)

Query: 77  VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
           V+++ +  +YMF  ++I+ D F                  P+ E     + + +E V+  
Sbjct: 36  VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 78

Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
           T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+  
Sbjct: 79  TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 132

Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
           ++     ++     S++  I + +++       +  WEGL+ +  +   +L        +
Sbjct: 133 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 180

Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
           + Y    + + T K + I       +P   E++     + F DG+     VPL G  KE 
Sbjct: 181 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 233

Query: 310 DESRREMIRILKDLKQKHPEK 330
            +  +  + ++ ++    P K
Sbjct: 234 PQYGKNPVVMVDEIMSSSPPK 254



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451

Query: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508

Query: 878 VL 879
           VL
Sbjct: 509 VL 510



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 71  LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874
            V  + W      + V   ++ +++++  +  F+
Sbjct: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157



 Score = 33.5 bits (75), Expect = 0.94
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472


>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
           [Homo sapiens]
          Length = 605

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)

Query: 77  VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
           V+++ +  +YMF  ++I+ D F                  P+ E     + + +E V+  
Sbjct: 83  VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125

Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
           T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+  
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179

Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
           ++     ++     S++  I + +++       +  WEGL+ +  +   +L        +
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 227

Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
           + Y    + + T K + I       +P   E++     + F DG+     VPL G  KE 
Sbjct: 228 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 280

Query: 310 DESRREMIRILKDLKQKHPEK 330
            +  +  + ++ ++    P K
Sbjct: 281 PQYGKNPVVMVDEIMSSSPPK 301



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498

Query: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555

Query: 878 VL 879
           VL
Sbjct: 556 VL 557



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874
            V  + W      + V   ++ +++++  +  F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204



 Score = 33.5 bits (75), Expect = 0.94
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519


>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
           [Homo sapiens]
          Length = 586

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 28/188 (14%)

Query: 77  VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
           V+++ +  +YMF  ++I+ D F                  P+ E     + + +E V+  
Sbjct: 83  VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125

Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
           T MA GSS PE+  S+I V    FI  GD+G  TIVGSA FN+  IIG+C      G+  
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179

Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
           ++     ++     S++  I + +++       +  WEGL+ +  +   +L+     K  
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQ 235

Query: 256 LFYKYMHK 263
            F+    K
Sbjct: 236 AFFTVKQK 243



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 758 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 817
           F  + L I + + I+  L +  G T+G+ D +  + F+A GTSVPD  AS   A Q +  
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479

Query: 818 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 877
           D ++ N  GSN  ++ +G+G+ W +  +     G    +++  L +SV L  +   V ++
Sbjct: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536

Query: 878 VL 879
           VL
Sbjct: 537 VL 538



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 840
           L + V    F+A G+S P+ FAS    +   + D  +G + GS   N+   IG+    A 
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176

Query: 841 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 874
            V  + W      + V   ++ +++++  +  F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204



 Score = 33.5 bits (75), Expect = 0.94
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
           + +  +T +A G+S P+ + SLI V   G   GD+  S  +GS  F++ + +G+
Sbjct: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 40/172 (23%)

Query: 77  VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
           V+++   ++Y+F+ ++I+ D  F+ ++ VIT + +                   +E V+ 
Sbjct: 455 VVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQI------------------SEDVAG 496

Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
            T MA G SAPE+  SLI V    FI+  ++G  TIVGSA FN+  +IG C        +
Sbjct: 497 ATFMAAGGSAPELFTSLIGV----FISHSNVGIGTIVGSAVFNILFVIGTCSLF-----S 547

Query: 195 RKIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTLFFF 241
           R+I +L        W +F  +  Y     M++  F   ++  WE LL L  +
Sbjct: 548 REILNL------TWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAY 593



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 46/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)

Query: 713  DEDEDESGEERLPSCFDY--------VMHFLTVFWKVLFACVPPTEYCHGWACFAV---- 760
            +E+E+E G E  P   D+        +  FL      L+  VP          F      
Sbjct: 885  EEEEEEKGNEE-PLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLG 943

Query: 761  SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 820
            SI+ I M + ++   A   G TIG+ + +  +  +A GTS+PD   S   A + +  D +
Sbjct: 944  SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMA 1002

Query: 821  IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV 878
            + +  GSN  ++ +G+ + W + ++   LQ      S G     V LF +  FV  S+
Sbjct: 1003 VSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS-SNGLFCAIVLLFLMLLFVISSI 1059



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)

Query: 130  NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
            +E +  LT++A G+S P+++ S+I V   G   GD+  S+ VGS  F++ +
Sbjct: 969  SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 1016


>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
          Length = 1805

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 487  VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
            +R E++  ++ +  AI   +P   A L    V  +TI+ +    + +FE     VS    
Sbjct: 950  IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006

Query: 547  VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
            V  + V+R     G   V +RT +GTA+ G  D+    GEL F+  E  K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065

Query: 607  EYE------RQENFFIALGEPKW-----MERGISALLLSPDVTDRKLTME 645
            E +      +   F + L  PK+          + ++  PD  DR  T +
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQ 1115



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)

Query: 416  LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
            + V+R+  D  K+  V Y+T+DG+A    DY   EG ++ +PGE  KE  V +++    D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068

Query: 472  DIF--EEDEHFFVRLSN 486
             +    +   F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085


>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
          Length = 1822

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 487  VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
            +R E++  ++ +  AI   +P   A L    V  +TI+ +    + +FE     VS    
Sbjct: 950  IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006

Query: 547  VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
            V  + V+R     G   V +RT +GTA+ G  D+    GEL F+  E  K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065

Query: 607  EYE------RQENFFIALGEPKW-----MERGISALLLSPDVTDRKLTME 645
            E +      +   F + L  PK+          + ++  PD  DR  T +
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQ 1115



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)

Query: 416  LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
            + V+R+  D  K+  V Y+T+DG+A    DY   EG ++ +PGE  KE  V +++    D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068

Query: 472  DIF--EEDEHFFVRLSN 486
             +    +   F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085


>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
          Length = 1752

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 15/170 (8%)

Query: 487  VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
            +R E++  ++ +  AI   +P   A L    V  +TI+ +    + +FE     VS    
Sbjct: 950  IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006

Query: 547  VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
            V  + V+R     G   V +RT +GTA+ G  D+    GEL F+  E  K ++VK+++ +
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLELQ 1065

Query: 607  EYE------RQENFFIALGEPKW-----MERGISALLLSPDVTDRKLTME 645
            E +      +   F + L  PK+          + ++  PD  DR  T +
Sbjct: 1066 EVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQ 1115



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)

Query: 416  LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
            + V+R+  D  K+  V Y+T+DG+A    DY   EG ++ +PGE  KE  V +++    D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068

Query: 472  DIF--EEDEHFFVRLSN 486
             +    +   F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085


>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
          Length = 2179

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 2/92 (2%)

Query: 396  SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVV- 454
            S + +    Y+  EN G + L ++R+G  M    +V  K    SA  G D+      ++ 
Sbjct: 1741 SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSA-FVGIKVNQVSAAVGKDFTVIPSKLIQ 1799

Query: 455  LKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN 486
              PG + K +++ I  D + E+DE F V L++
Sbjct: 1800 FDPGMSTKMWNIAITYDGLEEDDEVFEVILNS 1831


>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
          Length = 584

 Score = 34.3 bits (77), Expect = 0.55
 Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)

Query: 768 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 819
           L  I+G  A+ F C        T+ L  +V  V F+AFG   PD F++  A      A  
Sbjct: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169

Query: 820 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 879
           ++G + G+    V +   +A  +  ++         ++A    F   +F + A     ++
Sbjct: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219

Query: 880 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 923
           L+R R  L   LG            ++ L++ Y++   L  + Y
Sbjct: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)

Query: 747 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 806
           P   +   +  F  S L I      + ++    G    L ++V  +  +A+G S+ D F+
Sbjct: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474

Query: 807 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 838
               A Q  Y   +     G    N+ +G+GL
Sbjct: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505


>gi|223029420 SKI-like isoform 2 [Homo sapiens]
          Length = 638

 Score = 33.5 bits (75), Expect = 0.94
 Identities = 30/127 (23%), Positives = 51/127 (40%), Gaps = 16/127 (12%)

Query: 41  TGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMA 100
           +G+ N+S    +D   G+ L  WYP     GD +++   +     Y+++   ++A     
Sbjct: 359 SGKRNQS---KTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN--V 413

Query: 101 SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
           S+    SQ +E+T  + N   S           +N T      SA   L+  I   G G 
Sbjct: 414 SLTSAVSQSKELTKTEANASIS-----------NNSTSKRKSESATCNLVRDINKVGIGL 462

Query: 161 IAGDLGP 167
           +A    P
Sbjct: 463 VAAASSP 469


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,645,332
Number of Sequences: 37866
Number of extensions: 1549611
Number of successful extensions: 4377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 4147
Number of HSP's gapped (non-prelim): 135
length of query: 927
length of database: 18,247,518
effective HSP length: 112
effective length of query: 815
effective length of database: 14,006,526
effective search space: 11415318690
effective search space used: 11415318690
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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