Search of human proteins with 33589827

Search of human proteins with 33589827

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo
sapiens]
         (468 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   950   0.0  
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   612   e-175
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   452   e-127
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    426   e-119
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   419   e-117
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   393   e-109
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   387   e-107
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     385   e-107
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   373   e-103
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   370   e-102
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   300   2e-81
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   289   4e-78
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   286   3e-77
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   281   9e-76
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   278   1e-74
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   251   8e-67
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   250   2e-66
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   213   4e-55
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   213   4e-55
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   197   2e-50
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              188   8e-48
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   172   4e-43
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   146   4e-35
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   137   2e-32
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              127   2e-29
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    75   1e-13
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...    72   1e-12
gi|4504023 glycine receptor, beta [Homo sapiens]                       69   9e-12
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...    68   2e-11
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...    68   2e-11

>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  950 bits (2456), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYER 60
           MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYER
Sbjct: 1   MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYER 60

Query: 61  WVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKV 120
           WVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKV
Sbjct: 61  WVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKV 120

Query: 121 IRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFD 180
           IRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFD
Sbjct: 121 IRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFD 180

Query: 181 LQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYV 240
           LQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYV
Sbjct: 181 LQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYV 240

Query: 241 TYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE 300
           TYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE
Sbjct: 241 TYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIE 300

Query: 301 EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTL 360
           EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTL
Sbjct: 301 EIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTL 360

Query: 361 PKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW 420
           PKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW
Sbjct: 361 PKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDW 420

Query: 421 KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK 468
           KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
Sbjct: 421 KFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK 468


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  612 bits (1577), Expect = e-175
 Identities = 295/431 (68%), Positives = 354/431 (82%), Gaps = 17/431 (3%)

Query: 41  SSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLK 100
           +SIA++ED+LL+ LFQ Y++WVRPV H ND IK+ FGL ISQLVDVDEKNQLMTTNVWLK
Sbjct: 23  NSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLK 82

Query: 101 QEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVT 159
           QEW D KLRWNPDDYGGI  I+VPS+S+W PDIVLF+NADGRFEG+  TK +++ NGTV 
Sbjct: 83  QEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVV 142

Query: 160 WTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWE 219
           WTPPA+YKSSCT+DVTFFPFD QNCSMKFGSWTYDG+ VD+IL +++VD++DFFDNGEWE
Sbjct: 143 WTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWE 202

Query: 220 IVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG 279
           I++A G KGNR D    YP++TYSFV++RLPLFYTLFLIIPC+GLSFLTVLVFYLPS+EG
Sbjct: 203 ILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG 262

Query: 280 EKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHH 339
           EK+ L TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL+F MIFVTLSI+VTVF IN+HH
Sbjct: 263 EKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322

Query: 340 RSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRY----------------FTQKEETESG 383
           RSSST++ MAP V+++FL  LPKLLCM+ HVDRY                  +K++ +  
Sbjct: 323 RSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLS 382

Query: 384 SGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGS 443
            G K     LE A DSIRYI+RH+ KE+ + +VV+DWKF+AQVLDR+FLW FL VS+ GS
Sbjct: 383 DGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGS 442

Query: 444 LGLFVPVIYKW 454
           + +F P +  W
Sbjct: 443 VLIFTPALKMW 453


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  452 bits (1163), Expect = e-127
 Identities = 241/475 (50%), Positives = 309/475 (65%), Gaps = 63/475 (13%)

Query: 37  LSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTN 96
           L +  S  + ED L K LF+ Y RW RPV + +D + ++FGL+I+QL+DVDEKNQ+MTTN
Sbjct: 49  LPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTN 108

Query: 97  VWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYN 155
           VWLKQEW D KLRWNP D+G I  +RVPS+ +W PDIVL++NADG F  T  TK  +   
Sbjct: 109 VWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFST 168

Query: 156 GTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDN 215
           GTV W PPA YKSSC+IDVTFFPFD QNC MKFGSWTYD +++D+   +Q VD +D++++
Sbjct: 169 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES 228

Query: 216 GEWEIVSATGSKGNRTDSCCW--YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFY 273
           GEW IV+ATG+  ++   CC   YP VTY+FVI+RLPLFYT+ LIIPC+ +S LTVLVFY
Sbjct: 229 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY 288

Query: 274 LPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVF 333
           LPS+ GEKI LC SVL+SLTVFLL+I EIIPS+S VIPLIGEYL+FTMIFVTLSI++TVF
Sbjct: 289 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 348

Query: 334 AINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCM------------------------RSH 369
            +N+HHRS STH  M   VR   L  +P+ L M                         S+
Sbjct: 349 VLNVHHRSPSTH-TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESN 407

Query: 370 VD---RYFTQKEET----------------------ESGSGPKSS----------RNTLE 394
           VD   R    +EE                          SGPK+              ++
Sbjct: 408 VDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQ 467

Query: 395 AALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVP 449
            AL+ + YI  H+  E+    V EDWK++A V+DR+FLW F+ V  +G++GLF+P
Sbjct: 468 KALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLP 522


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  426 bits (1095), Expect = e-119
 Identities = 212/452 (46%), Positives = 301/452 (66%), Gaps = 51/452 (11%)

Query: 47  EDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106
           E+ L   LF  Y +++RPVE+++D + + F +AI+QL +VDE NQ+M TN+WL+  W D 
Sbjct: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93

Query: 107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPPAN 165
           KLRW+P +Y GI+ +RVP+D +W PDIVL++NA G F+    TK +++YNG +TWTPPA 
Sbjct: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153

Query: 166 YKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATG 225
           +KSSC +D+TFFPFD QNCS+KFGSWTYD +++D+++    VD  DF++N EWEI+ A+G
Sbjct: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213

Query: 226 SKGNRTDSCCW--YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKIC 283
            K +   +CC   Y  +TYSF I+RLP+FYT+ LIIPC+ +SFLTVLVFYLPS+ GEK+ 
Sbjct: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273

Query: 284 LCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS 343
           LC SVL+SLTVFLLVI E IPS+S V+PL+GEYL+FTMIFVTLSI+VTVF +NIH+R+ +
Sbjct: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333

Query: 344 THNAMAPLVRKIFLHTLPKLLCMRSHVDR------------------------------- 372
           TH  M   V+ +FL  LP++L MR  +D+                               
Sbjct: 334 TH-TMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHL 392

Query: 373 ---YFTQKEETESGSGPKSSRNTL-------------EAALDSIRYITRHIMKENDVREV 416
              +   K    + S  + S   L             E  ++S+++I  ++   N+ +EV
Sbjct: 393 KECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEV 452

Query: 417 VEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV 448
            +DWK++A V+DR+FLW F+ V + G+ GLF+
Sbjct: 453 EDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL 484


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  419 bits (1076), Expect = e-117
 Identities = 212/364 (58%), Positives = 269/364 (73%), Gaps = 12/364 (3%)

Query: 7   GPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVE 66
           GP A RLL  + L+ G         G  R  S   + A  E+ LLK LF  Y +W RPV 
Sbjct: 5   GPGAPRLLPPLLLLLGT--------GLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVA 56

Query: 67  HLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSD 126
           +++D + ++FGL+I+QL+DVDEKNQ+MTTNVW+KQEW D KLRW+P DY  +  IR+PS+
Sbjct: 57  NISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSE 116

Query: 127 SVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCS 185
            +W PDIVL++NADG F  T  TK  + ++G V WTPPA YKSSC+IDVTFFPFD QNC+
Sbjct: 117 LIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCT 176

Query: 186 MKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW--YPYVTYS 243
           MKFGSWTYD +++D++     VD+ DF+++GEW IV A G+   R   CC   YP +TY+
Sbjct: 177 MKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYA 236

Query: 244 FVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEII 303
           FVI+RLPLFYT+ LIIPC+ +S LTVLVFYLPS  GEKI LC SVL+SLTVFLL+I EII
Sbjct: 237 FVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEII 296

Query: 304 PSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKL 363
           PS+S VIPLIGEYL+FTMIFVTLSI++TVF +N+HHRS  TH  M   VR++FL  +P+L
Sbjct: 297 PSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTH-TMPTWVRRVFLDIVPRL 355

Query: 364 LCMR 367
           L M+
Sbjct: 356 LLMK 359



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 25/57 (43%), Positives = 41/57 (71%)

Query: 393 LEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVP 449
           L  A++ ++YI  H+  E+    V EDWK++A V+DR+FLW F+ V ++G++GLF+P
Sbjct: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  393 bits (1009), Expect = e-109
 Identities = 220/504 (43%), Positives = 305/504 (60%), Gaps = 81/504 (16%)

Query: 6   SGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPV 65
           S PR L LLLL  L   R   A                   E  L + LF+DY   +RPV
Sbjct: 13  SPPRLLLLLLLSLLPVARASEA-------------------EHRLFERLFEDYNEIIRPV 53

Query: 66  EHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPS 125
            +++D + I F +++SQLV VDE NQ+M TN+WLKQ W D KL+WNP DYGG + +RVP+
Sbjct: 54  ANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPA 113

Query: 126 DSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNC 184
             +W PDIVL++NA G F+    TK +++Y G VTW PPA +KSSC IDVT+FPFD QNC
Sbjct: 114 QKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNC 173

Query: 185 SMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW--YPYVTY 242
           +MKFGSW+YD +++D++L    ++ +D++++GEW I+ A G K +   +CC   YP +TY
Sbjct: 174 TMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITY 233

Query: 243 SFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEI 302
           S  I+RLPLFYT+ LIIPC+ +SFLTVLVFYLPS+ GEK+ LC SVL+SLTVFLLVI E 
Sbjct: 234 SLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITET 293

Query: 303 IPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPK 362
           IPS+S VIPLIGEYL+FTMIFVTLSI++TVF +N+H+R+ +TH  M   V+ +FL+ LP+
Sbjct: 294 IPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTH-TMPSWVKTVFLNLLPR 352

Query: 363 LLCM-RSHVDRYFTQKEETESGS--------------GPK-------------------- 387
           ++ M R   +    QK     G+              G K                    
Sbjct: 353 VMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKI 412

Query: 388 ---SSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQ------------------- 425
              S+  T  ++ +S+  +        +++E ++  K+IA+                   
Sbjct: 413 SNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVA 472

Query: 426 -VLDRMFLWTFLFVSIVGSLGLFV 448
            V+DR+FLW F  V I+G+ GLF+
Sbjct: 473 MVIDRIFLWVFTLVCILGTAGLFL 496


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  387 bits (994), Expect = e-107
 Identities = 198/427 (46%), Positives = 278/427 (65%), Gaps = 24/427 (5%)

Query: 44  AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEW 103
           ++HE  L+  LF+DY   VRPVE     +++  GL + QL++VDE NQ++TTNV LKQ+W
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80

Query: 104 IDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTP 162
           +D  L+WNPDDYGG+K I +PS+ +W PD+VL++NADG F     TK +++Y G +TWTP
Sbjct: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140

Query: 163 PANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVS 222
           PA +KS C I VT FPFD QNCSMK G+WTYDGS V I  E    D  +F ++GEW I  
Sbjct: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200

Query: 223 ATGSKGNRTDSCCW---YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG 279
           + G K + T SCC    Y  +TY FV++RLPL++ + +IIPC+  SFLT LVFYLP++ G
Sbjct: 201 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 260

Query: 280 EKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHH 339
           EK+ L  SVL+SLTVFLLVI E+IPS+S  +PLIG+Y++FTM+FV  SI++TV  IN HH
Sbjct: 261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 320

Query: 340 RSSSTHNAMAPLVRKIFLHTLPKLLCM-------RSHVD-RYFTQKEETESGSG------ 385
           RS STH  M   VRK+F+ T+P ++         R   D + FT+  +    SG      
Sbjct: 321 RSPSTH-VMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPP 379

Query: 386 -----PKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSI 440
                P      +++A++ I+YI   +  + +      +WK++A V+D + L  F+ V I
Sbjct: 380 MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 439

Query: 441 VGSLGLF 447
           +G+L +F
Sbjct: 440 IGTLAVF 446


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  385 bits (989), Expect = e-107
 Identities = 197/465 (42%), Positives = 288/465 (61%), Gaps = 57/465 (12%)

Query: 43  IAKHEDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLK 100
           +A  E+ L+ DL     Y   +RP    +  I IK  L+++QL+ V+E+ Q+MTTNVWLK
Sbjct: 23  VANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLK 82

Query: 101 QEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVT 159
           QEW D +L WN   Y G+ ++R+P+  +W PDIVL++NADG +E    T  ++R NG+V 
Sbjct: 83  QEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVL 142

Query: 160 WTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWE 219
           W PPA YKS+C I+V +FPFD QNC++KF SWTYD +++D++L        DF  +GEW+
Sbjct: 143 WLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWD 202

Query: 220 IVSATGSKG-NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNE 278
           IV+  G +  N  D    Y  VTY F+IKR PLFYT+ LIIPC+  + L +LVFYLPS+ 
Sbjct: 203 IVALPGRRTVNPQDPS--YVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDC 260

Query: 279 GEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIH 338
           GEK+ LC SVL++LT FLL+I +I+P +S  +PLIG+YL+FTM+ VT SI+ +V  +N+H
Sbjct: 261 GEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 320

Query: 339 HRSSSTHNAMAPLVRKIFLHTLPKLLCMR-----SHVDRYF-------TQKEETESGSGP 386
           HRS STH  MAP V++ FLH LP  L M+     S   R F       T+ E T + + P
Sbjct: 321 HRSPSTH-TMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTSP 379

Query: 387 KS--------------------------------------SRNTLEAALDSIRYITRHIM 408
            +                                       R  ++ AL+ + +I +H+ 
Sbjct: 380 SNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMK 439

Query: 409 KENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYK 453
            +++ + VVEDWK++A V+DR+FLW F+FV ++G++GLF+P +++
Sbjct: 440 NDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLFQ 484


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  373 bits (958), Expect = e-103
 Identities = 198/452 (43%), Positives = 278/452 (61%), Gaps = 49/452 (10%)

Query: 44  AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQ-- 101
           ++HE  L+  LF+DY   VRPVE     +++  GL + QL++VDE NQ++TTNV LKQ  
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80

Query: 102 -----------------------EWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDN 138
                                  +W+D  L+WNPDDYGG+K I +PS+ +W PD+VL++N
Sbjct: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140

Query: 139 ADGRFEGTS-TKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQ 197
           ADG F     TK +++Y G +TWTPPA +KS C I VT FPFD QNCSMK G+WTYDGS 
Sbjct: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200

Query: 198 VDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW---YPYVTYSFVIKRLPLFYT 254
           V I  E    D  +F ++GEW I  + G K + T SCC    Y  +TY FV++RLPL++ 
Sbjct: 201 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 260

Query: 255 LFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIG 314
           + +IIPC+  SFLT LVFYLP++ GEK+ L  SVL+SLTVFLLVI E+IPS+S  +PLIG
Sbjct: 261 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 320

Query: 315 EYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCM-------R 367
           +Y++FTM+FV  SI++TV  IN HHRS STH  M   VRK+F+ T+P ++         R
Sbjct: 321 KYMLFTMVFVIASIIITVIVINTHHRSPSTH-VMPNWVRKVFIDTIPNIMFFSTMKRPSR 379

Query: 368 SHVD-RYFTQKEETESGSG-----------PKSSRNTLEAALDSIRYITRHIMKENDVRE 415
              D + FT+  +    SG           P      +++A++ I+YI   +  + +   
Sbjct: 380 EKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNN 439

Query: 416 VVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLF 447
              +WK++A V+D + L  F+ V I+G+L +F
Sbjct: 440 AAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  370 bits (949), Expect = e-102
 Identities = 184/458 (40%), Positives = 285/458 (62%), Gaps = 53/458 (11%)

Query: 47  EDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWI 104
           E+ L++ L     Y + +RP  + ++ + ++  ++++QL+ V E+ Q+MTTNVWL QEW 
Sbjct: 29  EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88

Query: 105 DVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPP 163
           D +L W P+++  +K +R+PS  +W PD+VL++NADG +E +  +  V+ Y+G++ W PP
Sbjct: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148

Query: 164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSA 223
           A YKS+C I+V  FPFD QNC+MKF SWTYD +++D++L+ +     DF  +GEW+IV+ 
Sbjct: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVAL 208

Query: 224 TGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKIC 283
            G +    D    Y  +TY F+I+R PLFYT+ LIIPC+ ++ L +LVFYLPS+ GEK+ 
Sbjct: 209 PGRRNENPDDST-YVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMT 267

Query: 284 LCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS 343
           LC SVL++LTVFLL+I +I+P +S  +PL+G+YL+FTM+ VT SI+ +V  +N+HHRS +
Sbjct: 268 LCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT 327

Query: 344 THNAMAPLVRKIFLHTLPKLL--------CMRSHVDRYFTQKEETESG------------ 383
           TH  MAP V+ +FL  LP LL        C R  +     Q+E   +G            
Sbjct: 328 TH-TMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADS 386

Query: 384 ------------------------SGPKSSRNT----LEAALDSIRYITRHIMKENDVRE 415
                                   +GP  S       L  A+D +R+I  H+  E+D + 
Sbjct: 387 CTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQS 446

Query: 416 VVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYK 453
           V EDWK++A V+DR+FLW F+FV + G++G+F+  +++
Sbjct: 447 VSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQ 484


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  300 bits (767), Expect = 2e-81
 Identities = 164/474 (34%), Positives = 262/474 (55%), Gaps = 76/474 (16%)

Query: 47  EDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106
           E  L + LF  Y+  VRP   + D++++  GL ++QL+ ++EK++ M+T V+L  EW D 
Sbjct: 27  EGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDY 86

Query: 107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPAN 165
           +L W+P ++ GI  +R+ ++SVW PD+VL +N DG F+       V+  +G+V W PP  
Sbjct: 87  RLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGI 146

Query: 166 YKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL---------EDQDVDKRDFFDNG 216
           Y+SSC+I VT+FPFD QNC+M F S++YD S+V +           ++  + +  F +NG
Sbjct: 147 YRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENG 206

Query: 217 EWEIVSAT------------GSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGL 264
           +WEI+               G +G R +       V +  +I+R PLFY + +I PCI +
Sbjct: 207 QWEIIHKPSRLIQPPGDPRGGREGQRQE-------VIFYLIIRRKPLFYLVNVIAPCILI 259

Query: 265 SFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFV 324
           + L + VFYLP + GEK+ L    L++LTVFLL++ + +P +S  +P+I +YL+FTM+ V
Sbjct: 260 TLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLV 319

Query: 325 TLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR----------------- 367
           T S++++V  +N+HHRS  TH  M   VR+IF+H LP  L ++                 
Sbjct: 320 TFSVILSVVVLNLHHRSPHTHQ-MPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSS 378

Query: 368 ------SHVDRYFTQKEETE------SGSGPKSSRNTLEAALD----------------- 398
                    D YF +K  ++      +   P+ S   L   +D                 
Sbjct: 379 PGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVS 438

Query: 399 SIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIY 452
           SI YI R + ++ D   + EDW+F+A V+DR+FLWTF+  + VG+L +F+   Y
Sbjct: 439 SISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATY 492


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  289 bits (739), Expect = 4e-78
 Identities = 159/471 (33%), Positives = 258/471 (54%), Gaps = 66/471 (14%)

Query: 47  EDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWI 104
           E+ L++ LFQ+  Y + +RPV H  + + +   L +S L+ + E  + +TTNVW++  W 
Sbjct: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84

Query: 105 DVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYN-GTVTWTPP 163
           D +L+WN +++G I V+R+P D VW P+IVL +N DG F+ + +  V+ Y+ G V W PP
Sbjct: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144

Query: 164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD------------VDKRD 211
           A ++SSC I VT+FPFD QNCS+KF S  Y   ++ + L+               +D   
Sbjct: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204

Query: 212 FFDNGEWEIVSATGSKGNRTDSCCWYPY---VTYSFVIKRLPLFYTLFLIIPCIGLSFLT 268
           F +NGEWEIV           +    P    +T+  +I+R PLFY + +++PC+ +SF+ 
Sbjct: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264

Query: 269 VLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSI 328
            LVFYLP++ GEK  +  SVL++ +VFLL+I + +P++S  IPLIG++L+F M+ VT+ +
Sbjct: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

Query: 329 MVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR--------------------- 367
           ++ V  +NIH R+ STH  ++  V+K+FL TLP+LL M                      
Sbjct: 325 VICVIVLNIHFRTPSTH-VLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGY 383

Query: 368 -SHVDRYFTQKEETESGSGPKSSR-------------------------NTLEAALDSIR 401
            S  + YF  K  ++     +S R                         N L+ A+D   
Sbjct: 384 ISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGAN 443

Query: 402 YITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIY 452
           +I  H+  +N+  E  + W  +A+ +DR+ L+    V +VG+  +F+  +Y
Sbjct: 444 FIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFLQGVY 494


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  286 bits (732), Expect = 3e-77
 Identities = 156/455 (34%), Positives = 245/455 (53%), Gaps = 48/455 (10%)

Query: 33  AQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQL 92
           A R  +  ++  K+   L  DLF+DY   +RPVE  +  + +   + +SQ+ D+DE+NQ+
Sbjct: 17  ASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQI 76

Query: 93  MTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRF-EGTSTKTV 151
           +T  +W++Q W D  L W+ D Y G+  IR+PSD VW PDIVL++ AD    E  +T  V
Sbjct: 77  LTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVV 136

Query: 152 IRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRD 211
           +RY+G +TW  PA  KSSC +DVT+FPFD Q C++ FGSWTY+G+QVDI       D  D
Sbjct: 137 LRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSD 196

Query: 212 FFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTV 269
           F ++ EWE+      K   +  CC  PY  VT++ ++KR   FY + L+IPC+ +SFL  
Sbjct: 197 FIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAP 256

Query: 270 LVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIM 329
           L FYLP+  GEK+ L  ++L+++TVF L++ EI+P+S  V PLIG+Y + TM  +T S  
Sbjct: 257 LSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTA 315

Query: 330 VTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLL--------CM-------RSHVDRYF 374
           +T+  +NIH   +     +    R + L  + ++L        C+       R H+ + +
Sbjct: 316 LTIMVMNIHFCGAEA-RPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVY 374

Query: 375 TQKEETE-------------------------SGSGPKSSRN---TLEAALDSIRYITRH 406
           ++  E+                           G  P+ + +     +    +I YI + 
Sbjct: 375 SKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKC 434

Query: 407 IMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIV 441
           +           +WK +A+V+DR F+W F  +  V
Sbjct: 435 LKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFV 469


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  281 bits (719), Expect = 9e-76
 Identities = 152/420 (36%), Positives = 234/420 (55%), Gaps = 20/420 (4%)

Query: 50  LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLR 109
           L +DLF +Y   +RPV   +  + +   + +SQ++D+DE+NQ++T  +W++QEW D  LR
Sbjct: 33  LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92

Query: 110 WNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVTWTPPANYKS 168
           W+P+ YGG+  IR+PS  VW PDIVL++ AD +  G+ ST  V+R++G V W  PA  +S
Sbjct: 93  WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152

Query: 169 SCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKG 228
           SC +DV  FPFD Q+C + FGSWT+ G Q+D+          DF +N EW ++     + 
Sbjct: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRR 212

Query: 229 NRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCT 286
             T  CC  PY  VT++ +++R    Y   L++PC+ +S L  L F+LP++ GEK+ L  
Sbjct: 213 VLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGV 272

Query: 287 SVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHN 346
           +VL++LTVF L++ E +P +  V PLIG+Y + TM  VT S  +T+  +N+H+   S   
Sbjct: 273 TVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRP 331

Query: 347 AMAPLVRKIFLHTLPKLLCMR--------SHVDRYFTQKEETESGSGPKSS-------RN 391
             A   R + L  L + LC+R        S         +  E G+GP +          
Sbjct: 332 VPA-WARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLC 390

Query: 392 TLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVI 451
             EA L  +  I          +   EDWK +A+V+DR FL  F  +++V SL + V  +
Sbjct: 391 RQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  278 bits (710), Expect = 1e-74
 Identities = 133/320 (41%), Positives = 204/320 (63%), Gaps = 5/320 (1%)

Query: 23  RCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQ 82
           RC   G        L   S   + +  L K+L ++Y    RPV + +  + + F L++ Q
Sbjct: 2   RCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQ 61

Query: 83  LVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGR 142
           ++DVDEKNQ++TTN+WL+  W D  L+WN  +Y G+K +R P   +W PDI+L+++AD R
Sbjct: 62  IMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADER 121

Query: 143 FEGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDII 201
           F+ T  T  ++  +G   + PP  +KSSC IDV +FPFD+Q+C +KFGSW+Y G  +D+ 
Sbjct: 122 FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 181

Query: 202 LEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLII 259
           +++ D+    +  NGEW++V   G +  R   CC  PY  VT++  ++R  L+Y L L+I
Sbjct: 182 MQEADIS--GYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 239

Query: 260 PCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVF 319
           PC+ +S L +LVF LP++ GEKI L  +VL+SLTVF+L++ EI+P++S  +PLI +Y   
Sbjct: 240 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 299

Query: 320 TMIFVTLSIMVTVFAINIHH 339
           TMI V LS++VTV  +  HH
Sbjct: 300 TMIIVGLSVVVTVIVLQYHH 319



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 21/74 (28%), Positives = 35/74 (47%)

Query: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434
           T  E    G  P      L   L+ +RYI      +++   V  +WKF A V+DR+ L  
Sbjct: 415 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 474

Query: 435 FLFVSIVGSLGLFV 448
           F   +I+ ++G+ +
Sbjct: 475 FSVFTIICTIGILM 488


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  251 bits (642), Expect = 8e-67
 Identities = 149/459 (32%), Positives = 240/459 (52%), Gaps = 55/459 (11%)

Query: 43  IAKHED-SLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQ 101
           + K+E+  L   LF +Y+   RPV    D + I   + ++ L+ ++EK + +TT+VW+  
Sbjct: 19  VGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGI 78

Query: 102 EWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRY-NGTVTW 160
           +W D +L ++ DD+GGI+ +RVPS+ VW P+IVL +N DG+F       V+ Y  G+VTW
Sbjct: 79  DWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTW 138

Query: 161 TPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI---------ILEDQDVDKRD 211
            PPA Y+S C ++VT+FPFD QNCS+ F S TY+  +V+           +   D+D   
Sbjct: 139 LPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEA 198

Query: 212 FFDNGEWEIVSATG----SKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFL 267
           + +NGEW I    G      G  TD       V YS +I+R PLFY + +I+PC+ +S L
Sbjct: 199 YTENGEWAIDFCPGVIRRHHGGATDG-PGETDVIYSLIIRRKPLFYVINIIVPCVLISGL 257

Query: 268 TVLVFYLPSNE-GEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTL 326
            +L ++LP+   G+K  +  +VL++ TVFL +I + IP +S  +PL+G +L+F M+  TL
Sbjct: 258 VLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATL 317

Query: 327 SIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLL---------------------C 365
            +M  V  +N+  R+ +TH AM+P +R + L  LP+LL                      
Sbjct: 318 IVMNCVIVLNVSQRTPTTH-AMSPRLRHVLLELLPRLLGSPPPPEAPRAASPPRRASSVG 376

Query: 366 MRSHVDRYFTQKEETE-SGSGPKSSRNTLEAA---------------LDSIRYITRHIMK 409
           +    +    +K  +E    G +  + T  AA               +D++ ++      
Sbjct: 377 LLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRCCVDAVNFVAESTRD 436

Query: 410 ENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV 448
           +    E V DW  +   LD +  W  L +  VGS  +F+
Sbjct: 437 QEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL 475


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  250 bits (638), Expect = 2e-66
 Identities = 141/379 (37%), Positives = 216/379 (56%), Gaps = 36/379 (9%)

Query: 5   GSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRP 64
           G GP  L LLL V L        GA G  Q            E+ LL DL Q+Y+  +RP
Sbjct: 4   GQGPLLLLLLLAVCL--------GAQGRNQ------------EERLLADLMQNYDPNLRP 43

Query: 65  VEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVP 124
            E  +D + +   L ++ L+ ++E+ + +TTNVW++ +W D +LRW+P DY G+ V+RVP
Sbjct: 44  AERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVP 103

Query: 125 SDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQN 183
           S  VW PDIVL +N DG FE       ++  +G + W PPA ++S+C+I VT+FPFD QN
Sbjct: 104 STMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQN 163

Query: 184 CSMKFGSWTYDGSQVDIILEDQD--------VDKRDFFDNGEWEIVSATGS---KGNRTD 232
           CS+ F S TY  +++D+ L  +D        +D   F +NGEW I               
Sbjct: 164 CSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPA 223

Query: 233 SCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNE-GEKICLCTSVLVS 291
               +  V +  +I+R PLFY + +I PC+ +S + +L+ +LP+   G+K  +  +VL++
Sbjct: 224 QEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLA 283

Query: 292 LTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPL 351
            TVFL ++ + +P +S+ +PLI +YL F ++   L ++  V  +N+  RS  TH +MA  
Sbjct: 284 QTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTH-SMARG 342

Query: 352 VRKIFLHTLPKLLCMRSHV 370
           VRK+FL  LP+LL  R HV
Sbjct: 343 VRKVFLRLLPQLL--RMHV 359


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  213 bits (541), Expect = 4e-55
 Identities = 121/429 (28%), Positives = 213/429 (49%), Gaps = 37/429 (8%)

Query: 54  LFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPD 113
           L  +Y + VRPV        +   + +  +++VDEKNQ++TT +W +Q W D  L+WNP+
Sbjct: 47  LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 106

Query: 114 DYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTID 173
           D+  I  + +P+DS+W PDI++ +  D           IR+ G V    P    ++C++D
Sbjct: 107 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLD 166

Query: 174 VTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATGS-KG 228
           +  FPFD+QNCS+ F SW +    ++I L    E    D+  F + GEWE++      + 
Sbjct: 167 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE 226

Query: 229 NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSV 288
              +S  +Y  + +  VI+R PLFY + L++P I L  + ++ FYLP N GE++    ++
Sbjct: 227 FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286

Query: 289 LVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAM 348
           L+  +VFL+++ + +P+++   PLIG Y V  M  + +S+  T+F + + H+        
Sbjct: 287 LLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVP 346

Query: 349 APLVRKIFLHTLPKLLCMR---------------------------SHV----DRYFTQK 377
           A L R + L  +  LLC+R                           SH+    D   + +
Sbjct: 347 AWL-RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPR 405

Query: 378 EETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLF 437
           +       P+ +   +   L  +  I + + K +++REV  DW  +  VLD++    +L 
Sbjct: 406 DRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465

Query: 438 VSIVGSLGL 446
             +  S+ L
Sbjct: 466 AVLAYSITL 474


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  213 bits (541), Expect = 4e-55
 Identities = 121/429 (28%), Positives = 213/429 (49%), Gaps = 37/429 (8%)

Query: 54  LFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPD 113
           L  +Y + VRPV        +   + +  +++VDEKNQ++TT +W +Q W D  L+WNP+
Sbjct: 26  LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 85

Query: 114 DYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTID 173
           D+  I  + +P+DS+W PDI++ +  D           IR+ G V    P    ++C++D
Sbjct: 86  DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLD 145

Query: 174 VTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATGS-KG 228
           +  FPFD+QNCS+ F SW +    ++I L    E    D+  F + GEWE++      + 
Sbjct: 146 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE 205

Query: 229 NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSV 288
              +S  +Y  + +  VI+R PLFY + L++P I L  + ++ FYLP N GE++    ++
Sbjct: 206 FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 265

Query: 289 LVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAM 348
           L+  +VFL+++ + +P+++   PLIG Y V  M  + +S+  T+F + + H+        
Sbjct: 266 LLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVP 325

Query: 349 APLVRKIFLHTLPKLLCMR---------------------------SHV----DRYFTQK 377
           A L R + L  +  LLC+R                           SH+    D   + +
Sbjct: 326 AWL-RHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPR 384

Query: 378 EETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLF 437
           +       P+ +   +   L  +  I + + K +++REV  DW  +  VLD++    +L 
Sbjct: 385 DRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 444

Query: 438 VSIVGSLGL 446
             +  S+ L
Sbjct: 445 AVLAYSITL 453


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  197 bits (501), Expect = 2e-50
 Identities = 121/461 (26%), Positives = 214/461 (46%), Gaps = 69/461 (14%)

Query: 54  LFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPD 113
           L  +Y + VRPV        +   + +  +++VDEKNQ++TT +W +Q W D  L+WNP+
Sbjct: 47  LLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE 106

Query: 114 DYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTID 173
           D+  I  + +P+DS+W PDI++ +  D           IR+ G V    P    ++C++D
Sbjct: 107 DFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLD 166

Query: 174 VTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATG-SKG 228
           +  FPFD+QNCS+ F SW +    ++I L    E    D+  F + GEWE++      + 
Sbjct: 167 IYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFRE 226

Query: 229 NRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSV 288
              +S  +Y  + +  VI+R PLFY + L++P I L  + ++ FYLP N GE++    ++
Sbjct: 227 FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITL 286

Query: 289 LVSLTVFLLVIEEIIPSSSKVIPLIGE--------------------------------Y 316
           L+  +VFL+++ + +P+++   PLIG+                                Y
Sbjct: 287 LLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVY 346

Query: 317 LVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR--------- 367
            V  M  + +S+  T+F + + H+        A L R + L  +  LLC+R         
Sbjct: 347 FVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWL-RHLVLERIAWLLCLREQSTSQRPP 405

Query: 368 ------------------SHV----DRYFTQKEETESGSGPKSSRNTLEAALDSIRYITR 405
                             SH+    D   + ++       P+ +   +   L  +  I +
Sbjct: 406 ATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQ 465

Query: 406 HIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGL 446
            + K +++REV  DW  +  VLD++    +L   +  S+ L
Sbjct: 466 FLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 506


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  188 bits (478), Expect = 8e-48
 Identities = 92/206 (44%), Positives = 137/206 (66%), Gaps = 5/206 (2%)

Query: 137 DNADGRFEGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDG 195
           D AD RF+ T  T  ++  +G   + PP  +KSSC IDV +FPFD+Q+C +KFGSW+Y G
Sbjct: 26  DIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG 85

Query: 196 SQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFY 253
             +D+ +++ D+    +  NGEW++V   G +  R   CC  PY  VT++  ++R  L+Y
Sbjct: 86  WSLDLQMQEADIS--GYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYY 143

Query: 254 TLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLI 313
            L L+IPC+ +S L +LVF LP++ GEKI L  +VL+SLTVF+L++ EI+P++S  +PLI
Sbjct: 144 GLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLI 203

Query: 314 GEYLVFTMIFVTLSIMVTVFAINIHH 339
            +Y   TMI V LS++VTV  +  HH
Sbjct: 204 AQYFASTMIIVGLSVVVTVIVLQYHH 229



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 21/74 (28%), Positives = 35/74 (47%)

Query: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434
           T  E    G  P      L   L+ +RYI      +++   V  +WKF A V+DR+ L  
Sbjct: 325 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 384

Query: 435 FLFVSIVGSLGLFV 448
           F   +I+ ++G+ +
Sbjct: 385 FSVFTIICTIGILM 398


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  172 bits (437), Expect = 4e-43
 Identities = 109/402 (27%), Positives = 185/402 (46%), Gaps = 26/402 (6%)

Query: 50  LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLR 109
           L K L Q Y + VRPV +      +   L +  ++DVD +NQ++ T+VW ++ W D  L 
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 110 WNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSS 169
           WN   +  I+ I +P  ++W PDI++ +  D           +  +GT+    P    S+
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSA 154

Query: 170 CTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATG 225
           C+++   FPFD+QNCS+ F S  +    VD+      ED   DK+ F ++ EWE++S + 
Sbjct: 155 CSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSS 214

Query: 226 SKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLC 285
           +      S   +  + ++ V++R PL Y + L+IP I L  + +  FYLP N   +I   
Sbjct: 215 TYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFK 274

Query: 286 TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTH 345
           TSVLV  TVF + +   +P S    PLIG +    M F+ LS+  ++  +   H      
Sbjct: 275 TSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGG 334

Query: 346 NAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEE-------TESG--SGPKSSRNTLEAA 396
                             LC+R   D    + E        TES       +   TL+  
Sbjct: 335 QEQ-------------PFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEV 381

Query: 397 LDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFV 438
              ++ I+ ++  ++   +   +W  +    DR+   ++LF+
Sbjct: 382 WSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFM 423


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  146 bits (368), Expect = 4e-35
 Identities = 77/301 (25%), Positives = 153/301 (50%), Gaps = 7/301 (2%)

Query: 63  RPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIR 122
           RPV +++   ++    A+S ++DV+E+  L+++ +WL+  W +  + WNP++  GI  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 123 VPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQ 182
           + + ++W PDI + +  D           +   G + +  P    S C +D+ +FPFD Q
Sbjct: 130 MAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQ 189

Query: 183 NCSMKFGSWTY--DGSQVDI---ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWY 237
           NC++ F S+ Y  D   +D+   + E  D  +     +GEWE++  + +    +     Y
Sbjct: 190 NCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLY 249

Query: 238 PYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLL 297
             + +   I+R P  Y + L++P   L  +  L FYLP   G ++    ++L+   VFLL
Sbjct: 250 DQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLL 309

Query: 298 VIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFL 357
           ++ +++P+S    PLIG Y    +  +  S++ T+F  ++ H +++    +   +  + L
Sbjct: 310 MMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLL 367

Query: 358 H 358
           H
Sbjct: 368 H 368


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  137 bits (346), Expect = 2e-32
 Identities = 78/309 (25%), Positives = 147/309 (47%), Gaps = 8/309 (2%)

Query: 63  RPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIR 122
           RP  + +   ++     +S ++ VD + QL+T+ +W+   W +  + WNP +  GI  + 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 123 VPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQ 182
           V ++++W PDI + ++ D     +     I   G + +  P    S C +D+ +FPFD Q
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQ 174

Query: 183 NCSMKFGSWTYDGSQVDI-----ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWY 237
           NC+  F S+ Y    + +     + E  D  ++     GEWE++    +    +     Y
Sbjct: 175 NCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLY 234

Query: 238 PYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLL 297
             + +   I+R P  Y + L++P   L  +  L FYLP+    +     ++L+   VFLL
Sbjct: 235 DQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLL 294

Query: 298 VIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFL 357
           ++ +++P+S    PLI  Y    +  + +S++ TVF   + H +++    M   +  + L
Sbjct: 295 MMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLL 352

Query: 358 H-TLPKLLC 365
           H T P   C
Sbjct: 353 HCTSPGRCC 361


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  127 bits (320), Expect = 2e-29
 Identities = 62/137 (45%), Positives = 91/137 (66%), Gaps = 2/137 (1%)

Query: 205 QDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCI 262
           Q+ D   +  NGEW++V   G +  R   CC  PY  VT++  ++R  L+Y L L+IPC+
Sbjct: 2   QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 263 GLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMI 322
            +S L +LVF LP++ GEKI L  +VL+SLTVF+L++ EI+P++S  +PLI +Y   TMI
Sbjct: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121

Query: 323 FVTLSIMVTVFAINIHH 339
            V LS++VTV  +  HH
Sbjct: 122 IVGLSVVVTVIVLQYHH 138



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 21/74 (28%), Positives = 35/74 (47%)

Query: 375 TQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWT 434
           T  E    G  P      L   L+ +RYI      +++   V  +WKF A V+DR+ L  
Sbjct: 234 THDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMA 293

Query: 435 FLFVSIVGSLGLFV 448
           F   +I+ ++G+ +
Sbjct: 294 FSVFTIICTIGILM 307


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 67/314 (21%), Positives = 135/314 (42%), Gaps = 14/314 (4%)

Query: 17  VQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKF 76
           + L   R  + G+    + G S+  S+   E+     L   Y +++RP     + ++I  
Sbjct: 12  LSLFTERMCIQGSQFNVEVGRSDKLSLPGFEN-----LTAGYNKFLRP-NFGGEPVQIAL 65

Query: 77  GLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLF 136
            L I+ +  + E N   T  ++L+Q W+D +L +  +    +    V  + +W PD  + 
Sbjct: 66  TLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLV--EFLWVPDTYIV 123

Query: 137 DNADGRF-EGTSTKTVIRY--NGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTY 193
           ++      E T    +IR   NGTV +        +C +D++ +P D Q C ++  SW Y
Sbjct: 124 ESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGY 183

Query: 194 DGSQVDI--ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPL 251
           DG+ V+   +  +  V   +     ++ I                Y  +   F ++R  L
Sbjct: 184 DGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVL 243

Query: 252 FYTLFLIIPCIGLSFLTVLVFYLP-SNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVI 310
           ++ L   +P   L  L+ + F++   +   + C+  + ++S+T  ++     +P+++  I
Sbjct: 244 YFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFI 303

Query: 311 PLIGEYLVFTMIFV 324
             I  YL     FV
Sbjct: 304 KAIDVYLGICFSFV 317


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 67/312 (21%), Positives = 145/312 (46%), Gaps = 10/312 (3%)

Query: 28  GAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVD 87
           G  G   R +++P +++  ++++ K L + Y+  +RP +     + +   + I+ +  V 
Sbjct: 19  GTRGSEPRSVNDPGNMSFVKETVDK-LLKGYDIRLRP-DFGGPPVCVGMNIDIASIDMVS 76

Query: 88  EKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS 147
           E N   T  ++ +Q W D +L ++          RV +D +W PD    ++      G +
Sbjct: 77  EVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFVHGVT 135

Query: 148 TKT-VIRYN--GTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILE- 203
            K  +IR +  GTV +       ++C +D+  +P D QNC+++  S+ Y    ++     
Sbjct: 136 VKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRG 195

Query: 204 -DQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCI 262
            D+ V   +  +  ++ IV       N   +   YP ++ SF +KR   ++ L   +P I
Sbjct: 196 GDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSI 255

Query: 263 GLSFLTVLVFYLPSN-EGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTM 321
            ++ L+ + F++  +    ++ L  + ++++T     + E +P     +  I  YL+   
Sbjct: 256 LITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLP-KIPYVKAIDMYLMGCF 314

Query: 322 IFVTLSIMVTVF 333
           +FV L+++   F
Sbjct: 315 VFVFLALLEYAF 326


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 61/296 (20%), Positives = 124/296 (41%), Gaps = 13/296 (4%)

Query: 44  AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEW 103
           A    ++L  L   Y+  +RP       + +   + I+    + E       N++L+Q+W
Sbjct: 53  ANSTSNILNRLLVSYDPRIRP-NFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111

Query: 104 IDVKLRWNPDDYGGIKVIRVPSDS---VWTPDIVLFDNADGRFEGTSTKTVIRY---NGT 157
            D +L+  P D+ G   + V       +W PD+   +     F   + + ++ +   +G 
Sbjct: 112 NDPRLKL-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGD 170

Query: 158 VTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGE 217
           V  +   +   SC +D+T FP D Q C M+  S+ Y    +  I +  D  + +     +
Sbjct: 171 VLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQ 230

Query: 218 WEIVSATGSKGNRT---DSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYL 274
           ++I       GN T       +Y  V   F ++R   FY + +  P + +  L+ L F++
Sbjct: 231 FDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWI 290

Query: 275 -PSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIM 329
            P     ++ L    ++SL      +   +P  S  +  +  +L+  ++F   S++
Sbjct: 291 NPDASAARVPLGIFSVLSLASECTTLAAELPKVS-YVKALDVWLIACLLFGFASLV 345


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 57/237 (24%), Positives = 106/237 (44%), Gaps = 19/237 (8%)

Query: 50  LLKDLFQDYERWVRPVEHLNDKIKIKF-GLAISQLVDVDEKNQLMTTNVWLKQEWIDVKL 108
           +L  L   Y+  +RP   L D I   F  + ++    V + +   T +V+ +Q+W D +L
Sbjct: 45  ILDRLLDGYDNRLRP--GLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102

Query: 109 RWNPDDYGGIKVIRVPS---DSVWTPDIVLFDNADGRFEGTSTKTV----IRYNGTVTWT 161
           ++     G + ++R+ +     +WTPD   F N         T       I+ +GT+ +T
Sbjct: 103 KFK----GPMNILRLNNLMASKIWTPD-TFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYT 157

Query: 162 PPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNG----E 217
                ++ C + +  FP D  +C +KFGS+ Y  S+V  I      D      +G    +
Sbjct: 158 MRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQ 217

Query: 218 WEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYL 274
           ++++  +  K     S   Y  +T  F +KR   ++ +   +PCI    L+ + F+L
Sbjct: 218 YDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 274


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 57/237 (24%), Positives = 106/237 (44%), Gaps = 19/237 (8%)

Query: 50  LLKDLFQDYERWVRPVEHLNDKIKIKF-GLAISQLVDVDEKNQLMTTNVWLKQEWIDVKL 108
           +L  L   Y+  +RP   L D I   F  + ++    V + +   T +V+ +Q+W D +L
Sbjct: 45  ILDRLLDGYDNRLRP--GLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102

Query: 109 RWNPDDYGGIKVIRVPS---DSVWTPDIVLFDNADGRFEGTSTKTV----IRYNGTVTWT 161
           ++     G + ++R+ +     +WTPD   F N         T       I+ +GT+ +T
Sbjct: 103 KFK----GPMNILRLNNLMASKIWTPD-TFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYT 157

Query: 162 PPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNG----E 217
                ++ C + +  FP D  +C +KFGS+ Y  S+V  I      D      +G    +
Sbjct: 158 MRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQ 217

Query: 218 WEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYL 274
           ++++  +  K     S   Y  +T  F +KR   ++ +   +PCI    L+ + F+L
Sbjct: 218 YDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 274


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,356,691
Number of Sequences: 37866
Number of extensions: 750726
Number of successful extensions: 2027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1829
Number of HSP's gapped (non-prelim): 96
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.