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Search of human proteins with 33563376
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 1568 0.0
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 202 7e-52
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 202 7e-52
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 202 7e-52
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 201 2e-51
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 153 7e-37
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 120 5e-27
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 120 5e-27
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 120 5e-27
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 120 5e-27
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 114 3e-25
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 114 3e-25
gi|23503283 TBC1 domain family, member 21 [Homo sapiens] 82 1e-15
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 81 4e-15
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 77 8e-14
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 77 8e-14
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 75 3e-13
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 67 8e-11
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 62 2e-09
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 62 3e-09
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 61 3e-09
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 61 3e-09
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 61 3e-09
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 60 6e-09
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 60 6e-09
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 60 6e-09
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 60 6e-09
gi|149999613 TBC1 domain family, member 3B [Homo sapiens] 60 1e-08
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 58 3e-08
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 58 3e-08
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 1568 bits (4061), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 60
MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP
Sbjct: 1 MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHP 60
Query: 61 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 120
GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG
Sbjct: 61 GYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSG 120
Query: 121 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 180
ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA
Sbjct: 121 ASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPA 180
Query: 181 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 240
CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS
Sbjct: 181 CSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLS 240
Query: 241 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 300
PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR
Sbjct: 241 PISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFR 300
Query: 301 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 360
VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL
Sbjct: 301 VDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQL 360
Query: 361 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 420
KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA
Sbjct: 361 KDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKA 420
Query: 421 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 480
IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF
Sbjct: 421 IFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAF 480
Query: 481 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 540
WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI
Sbjct: 481 WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI 540
Query: 541 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 600
LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED
Sbjct: 541 LAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGED 600
Query: 601 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 660
GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ
Sbjct: 601 GLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQ 660
Query: 661 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 720
LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM
Sbjct: 661 LATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSM 720
Query: 721 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 767
PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR
Sbjct: 721 PAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR 767
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 202 bits (515), Expect = 7e-52
Identities = 109/319 (34%), Positives = 178/319 (55%), Gaps = 4/319 (1%)
Query: 396 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
+ + W +++ G++ +++ IF GG+ ++R + W FLL Y+ +ST EER L+
Sbjct: 308 VSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQ 367
Query: 456 LQKRKEY--SEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513
QK EY ++Q K +S E+ + R+ + ++KDV RTDR N+F+ G+DNP + +
Sbjct: 368 KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILL 427
Query: 514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDME 573
IL+ Y +Y+ +GY QGMSDL++P+L + +E D FWCF M + + M+
Sbjct: 428 HDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMK 487
Query: 574 KQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA 633
QL+ L LLRL F +L S +D + FC RWLL+ FKREF + LR+WE W
Sbjct: 488 TQLIQLSTLLRLLDSGFCSYLES--QDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT 545
Query: 634 HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693
FHL +C AI+ ++E+ +++L H L+M ++ E +L KA ++ Q
Sbjct: 546 ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 605
Query: 694 RLLPRIPCSLHDLCKLCGS 712
+P ++ ++ L GS
Sbjct: 606 VKCKELPQAVCEILGLQGS 624
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 202 bits (515), Expect = 7e-52
Identities = 109/319 (34%), Positives = 178/319 (55%), Gaps = 4/319 (1%)
Query: 396 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
+ + W +++ G++ +++ IF GG+ ++R + W FLL Y+ +ST EER L+
Sbjct: 322 VSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQ 381
Query: 456 LQKRKEY--SEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513
QK EY ++Q K +S E+ + R+ + ++KDV RTDR N+F+ G+DNP + +
Sbjct: 382 KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILL 441
Query: 514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDME 573
IL+ Y +Y+ +GY QGMSDL++P+L + +E D FWCF M + + M+
Sbjct: 442 HDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMK 501
Query: 574 KQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA 633
QL+ L LLRL F +L S +D + FC RWLL+ FKREF + LR+WE W
Sbjct: 502 TQLIQLSTLLRLLDSGFCSYLES--QDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT 559
Query: 634 HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693
FHL +C AI+ ++E+ +++L H L+M ++ E +L KA ++ Q
Sbjct: 560 ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 619
Query: 694 RLLPRIPCSLHDLCKLCGS 712
+P ++ ++ L GS
Sbjct: 620 VKCKELPQAVCEILGLQGS 638
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 202 bits (515), Expect = 7e-52
Identities = 109/319 (34%), Positives = 178/319 (55%), Gaps = 4/319 (1%)
Query: 396 LGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
+ + W +++ G++ +++ IF GG+ ++R + W FLL Y+ +ST EER L+
Sbjct: 339 VSLEEWTKNIDSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQ 398
Query: 456 LQKRKEY--SEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513
QK EY ++Q K +S E+ + R+ + ++KDV RTDR N+F+ G+DNP + +
Sbjct: 399 KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILL 458
Query: 514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDME 573
IL+ Y +Y+ +GY QGMSDL++P+L + +E D FWCF M + + M+
Sbjct: 459 HDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMK 518
Query: 574 KQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA 633
QL+ L LLRL F +L S +D + FC RWLL+ FKREF + LR+WE W
Sbjct: 519 TQLIQLSTLLRLLDSGFCSYLES--QDSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT 576
Query: 634 HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693
FHL +C AI+ ++E+ +++L H L+M ++ E +L KA ++ Q
Sbjct: 577 ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 636
Query: 694 RLLPRIPCSLHDLCKLCGS 712
+P ++ ++ L GS
Sbjct: 637 VKCKELPQAVCEILGLQGS 655
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 201 bits (511), Expect = 2e-51
Identities = 117/348 (33%), Positives = 181/348 (52%), Gaps = 14/348 (4%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460
W H+ G++++ +L+ IF GG+ S+R E W FLL Y S E T+EE +A +K
Sbjct: 286 WARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTD 345
Query: 461 EYSEIQQKRLSMTPEEHR--AFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILL 518
EY ++ + S++PE+ R + + +++DV RTDR N+F+ G +NP + + ILL
Sbjct: 346 EYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILL 405
Query: 519 NYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLY 578
Y +Y+ +GY QGMSDL++PIL + +E D FWCF G M+ E M++QL
Sbjct: 406 TYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGR 465
Query: 579 LRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638
L LLR+ L S +D + FC RWLL+ FKREFP + LR+WE W
Sbjct: 466 LLLLLRVLDPLLCDFLDS--QDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGP 523
Query: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPR 698
HL + AI+ + D ++ ++++L H L M ++ E VL +A +L Q P
Sbjct: 524 NLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPE 583
Query: 699 IPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSP 746
+P ++ ++ G P E P + P T P+P
Sbjct: 584 LPHNVQEIL----------GLAPPAEPHSPSPTASPLPLSPTRAPPTP 621
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 153 bits (386), Expect = 7e-37
Identities = 91/236 (38%), Positives = 128/236 (54%), Gaps = 6/236 (2%)
Query: 404 HLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYS 463
+LN GQ+ +LR I+ GG++ S+R VW +LL Y T ER +K +EY
Sbjct: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266
Query: 464 EIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRG-EDNPNVESMRRILLNYAV 522
+++ + E F R+ TV KDV+RTDR + ++ G ED P++ ++ +L YAV
Sbjct: 267 QLKSEWAQRANPEDLEFIRS---TVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAV 323
Query: 523 YNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLREL 582
+P V Y QGMSDL +PILA + E F CF G+M+ P M + +L+ L
Sbjct: 324 THPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLL 383
Query: 583 LRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638
LR FYQ+L G D L FC+RWLLL KREF +ALR+ E W+ D
Sbjct: 384 LRHADPDFYQYLQEAGADDL--FFCYRWLLLELKREFAFDDALRMLEVTWSSLPPD 437
Score = 35.4 bits (80), Expect = 0.20
Identities = 17/54 (31%), Positives = 31/54 (57%)
Query: 640 FHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQF 693
F LF+C+AI+ + D ++ L +++ +HF L + VLR+AR+L +
Sbjct: 617 FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADY 670
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 120 bits (301), Expect = 5e-27
Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
E S + ++ +PE + N+ ++KDV R DRN +F N+E +R I+ +Y
Sbjct: 797 EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 852
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
+ +GY QGM DL+AP+L + DE+ F CF LM+ + + P M+ +R
Sbjct: 853 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 911
Query: 581 ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638
L+++ ++ L+ D FC+RW LL FKRE + +WE WA H +
Sbjct: 912 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 970
Query: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ LFI +A+V +Y D ++E + ++ F +A N + VL+ AR L+Y+ + L
Sbjct: 971 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1028
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEERE 452
W +L++ EE+ LR I++GGI IR VWPFLL +Y T ER+
Sbjct: 539 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERK 589
Score = 34.3 bits (77), Expect = 0.45
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KNNV V P + ++ + PGYL L+ D M L W PN
Sbjct: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 120 bits (301), Expect = 5e-27
Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
E S + ++ +PE + N+ ++KDV R DRN +F N+E +R I+ +Y
Sbjct: 858 EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 913
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
+ +GY QGM DL+AP+L + DE+ F CF LM+ + + P M+ +R
Sbjct: 914 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 972
Query: 581 ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638
L+++ ++ L+ D FC+RW LL FKRE + +WE WA H +
Sbjct: 973 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1031
Query: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ LFI +A+V +Y D ++E + ++ F +A N + VL+ AR L+Y+ + L
Sbjct: 1032 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1089
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460
W +L++ EE+ LR I++GGI IR VWPFLL +Y T ER+ + Q
Sbjct: 539 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHA 597
Query: 461 EYSE 464
Y++
Sbjct: 598 CYAQ 601
Score = 34.3 bits (77), Expect = 0.45
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KNNV V P + ++ + PGYL L+ D M L W PN
Sbjct: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 120 bits (301), Expect = 5e-27
Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
E S + ++ +PE + N+ ++KDV R DRN +F N+E +R I+ +Y
Sbjct: 852 EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 907
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
+ +GY QGM DL+AP+L + DE+ F CF LM+ + + P M+ +R
Sbjct: 908 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 966
Query: 581 ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638
L+++ ++ L+ D FC+RW LL FKRE + +WE WA H +
Sbjct: 967 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1025
Query: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ LFI +A+V +Y D ++E + ++ F +A N + VL+ AR L+Y+ + L
Sbjct: 1026 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1083
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEERE 452
W +L++ EE+ LR I++GGI IR VWPFLL +Y T ER+
Sbjct: 594 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERK 644
Score = 34.3 bits (77), Expect = 0.45
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KNNV V P + ++ + PGYL L+ D M L W PN
Sbjct: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 120 bits (301), Expect = 5e-27
Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
E S + ++ +PE + N+ ++KDV R DRN +F N+E +R I+ +Y
Sbjct: 913 EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 968
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
+ +GY QGM DL+AP+L + DE+ F CF LM+ + + P M+ +R
Sbjct: 969 IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 1027
Query: 581 ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638
L+++ ++ L+ D FC+RW LL FKRE + +WE WA H +
Sbjct: 1028 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1086
Query: 639 YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ LFI +A+V +Y D ++E + ++ F +A N + VL+ AR L+Y+ + L
Sbjct: 1087 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1144
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460
W +L++ EE+ LR I++GGI IR VWPFLL +Y T ER+ + Q
Sbjct: 594 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHA 652
Query: 461 EYSE 464
Y++
Sbjct: 653 CYAQ 656
Score = 34.3 bits (77), Expect = 0.45
Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KNNV V P + ++ + PGYL L+ D M L W PN
Sbjct: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1006
Score = 114 bits (285), Expect = 3e-25
Identities = 66/211 (31%), Positives = 113/211 (53%), Gaps = 7/211 (3%)
Query: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
+DKDV R DRN +F PN+E +R ++ +Y + VGY QGM DL+AP+L + ++
Sbjct: 797 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 853
Query: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFC 607
+ CF LM+ + + P M+ +R L+++ ++ L+ D FC
Sbjct: 854 QLAYSCFSHLMKR-MSQNFPNGGAMDTHFANMRSLIQILDSELFE-LMHQNGDYTHFYFC 911
Query: 608 HRWLLLCFKREFPEAEALRIWEACWA--HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQ 665
+RW LL FKRE + +WE WA H +++F LFI +A+V Y + + + +
Sbjct: 912 YRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTD 971
Query: 666 MLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ F A H + + +LR AR L+++ ++L
Sbjct: 972 IIKFFNERAEHHDAQEILRIARDLVHKVQML 1002
Score = 41.2 bits (95), Expect = 0.004
Identities = 17/53 (32%), Positives = 31/53 (58%)
Query: 413 EEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEI 465
+E +L + +++GGI+ IR +VWPFLL +Y + +E E + Y ++
Sbjct: 554 KELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 606
Score = 33.5 bits (75), Expect = 0.76
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KN+V V P E ++ + PGYL L+ + +L L W PN
Sbjct: 258 LLYGKNHVLVQPKEDMEAV----PGYLSLHQSAE-----SLTLKWTPN 296
>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1051
Score = 114 bits (285), Expect = 3e-25
Identities = 66/211 (31%), Positives = 113/211 (53%), Gaps = 7/211 (3%)
Query: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
+DKDV R DRN +F PN+E +R ++ +Y + VGY QGM DL+AP+L + ++
Sbjct: 842 IDKDVQRCDRNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDND 898
Query: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFC 607
+ CF LM+ + + P M+ +R L+++ ++ L+ D FC
Sbjct: 899 QLAYSCFSHLMKR-MSQNFPNGGAMDTHFANMRSLIQILDSELFE-LMHQNGDYTHFYFC 956
Query: 608 HRWLLLCFKREFPEAEALRIWEACWA--HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQ 665
+RW LL FKRE + +WE WA H +++F LFI +A+V Y + + + +
Sbjct: 957 YRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTD 1016
Query: 666 MLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696
++ F A H + + +LR AR L+++ ++L
Sbjct: 1017 IIKFFNERAEHHDAQEILRIARDLVHKVQML 1047
Score = 41.2 bits (95), Expect = 0.004
Identities = 17/53 (32%), Positives = 31/53 (58%)
Query: 413 EEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEI 465
+E +L + +++GGI+ IR +VWPFLL +Y + +E E + Y ++
Sbjct: 599 KELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 651
Score = 33.5 bits (75), Expect = 0.76
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 9/48 (18%)
Query: 37 IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84
++Y KN+V V P E ++ + PGYL L+ + +L L W PN
Sbjct: 258 LLYGKNHVLVQPKEDMEAV----PGYLSLHQSAE-----SLTLKWTPN 296
>gi|23503283 TBC1 domain family, member 21 [Homo sapiens]
Length = 336
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/292 (25%), Positives = 124/292 (42%), Gaps = 26/292 (8%)
Query: 425 GIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTP---EEHRAFW 481
G+ +R E W FL Y+S +S+ +ER + +RK Y + Q + P HR F
Sbjct: 57 GLHPFVRTEAWKFLTGYFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQPLLENLHRNFT 116
Query: 482 -------RNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMS 534
R++Q DKD + G + + + +ILL V N Y QG
Sbjct: 117 ETRNNIARDIQKIYDKDPL----------GNVLIDKKRLEKILLLSYVCNTQAEYQQGFH 166
Query: 535 DLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHL 594
+++ V + +TFW F +Q T S + + K L L L+ F +HL
Sbjct: 167 EMMMLFQLMVEHDHETFWLFQFFLQKTEH-SCVINIGVAKNLDMLSTLITFLDPVFAEHL 225
Query: 595 VSLGEDGLQMLFCHRWLLLCFKREFPEAEAL-RIWEACWAHYQTDYFHLFICVAIVAIYG 653
G +Q LF W CF+R F + + R+WE F + + +++ +
Sbjct: 226 KGKGAGAVQSLF--PWFCFCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVR 283
Query: 654 DDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHD 705
+ V+++ + D +LL NL EL+ A ++Y + +P +L D
Sbjct: 284 EQVLQESMGGDDILLACNNLIDLDADELI--SAACVVYAELIQKDVPQTLKD 333
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 80.9 bits (198), Expect = 4e-15
Identities = 76/307 (24%), Positives = 131/307 (42%), Gaps = 50/307 (16%)
Query: 425 GIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKE--YSEIQQKRLSMTPEEHRAFWR 482
G+ +R W L Y + ER L LQ+++E + I+Q S E H+ +R
Sbjct: 210 GVPREVRPITWRLLSGYLP---ANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYR 266
Query: 483 NVQFTVDKDVVRTDRNNQFFRGEDNPNVESM-RRILLNYAVYNPAVGYSQGMSDLVAPIL 541
+ D+ RT+ F+ P V+ + RIL +A+ +PA GY QG++DLV P
Sbjct: 267 QIHI----DIPRTNPLIPLFQ---QPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFF 319
Query: 542 AEVLD-----------------------ESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLY 578
L E+D+FWC L+ + ++K++
Sbjct: 320 VVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKA 379
Query: 579 LRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTD 638
L EL+ + + H + LQ F RW+ RE P +R+W+ YQ++
Sbjct: 380 LEELVSRIDEQVHNHFRRYEVEYLQ--FAFRWMNNLLMRELPLRCTIRLWDT----YQSE 433
Query: 639 -----YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGE---LVLRKARSLL 690
+FHL++C A + + ++++++ ++L +H E L+L +A L
Sbjct: 434 PEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLK 493
Query: 691 YQFRLLP 697
Y F P
Sbjct: 494 YMFADAP 500
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 76.6 bits (187), Expect = 8e-14
Identities = 63/233 (27%), Positives = 100/233 (42%), Gaps = 27/233 (11%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460
WL L + + K + I+ GI + +RGEVW LL E ++ + R
Sbjct: 77 WLKMLKGWEKYKNTEKFHRRIY-KGIPLQLRGEVWALLL----------EIPKMKEETRD 125
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
YS+++ + +P+ + +D DV RT R++ FR +S+ +L Y
Sbjct: 126 LYSKLKHRARGCSPDIRQ---------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAY 176
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
++YN VGY QGMS + A +L ++E D FW V L +LL +
Sbjct: 177 SIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQ 235
Query: 581 E----LLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWE 629
E +L + QHL S ++ + +W CF P LRIW+
Sbjct: 236 EHHEKILNKFLSKLKQHLDS--QEIYTSFYTMKWFFQCFLDRTPFTLNLRIWD 286
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 76.6 bits (187), Expect = 8e-14
Identities = 63/233 (27%), Positives = 100/233 (42%), Gaps = 27/233 (11%)
Query: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460
WL L + + K + I+ GI + +RGEVW LL E ++ + R
Sbjct: 94 WLKMLKGWEKYKNTEKFHRRIY-KGIPLQLRGEVWALLL----------EIPKMKEETRD 142
Query: 461 EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520
YS+++ + +P+ + +D DV RT R++ FR +S+ +L Y
Sbjct: 143 LYSKLKHRARGCSPDIRQ---------IDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAY 193
Query: 521 AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580
++YN VGY QGMS + A +L ++E D FW V L +LL +
Sbjct: 194 SIYNTEVGYCQGMSQITA-LLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQ 252
Query: 581 E----LLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWE 629
E +L + QHL S ++ + +W CF P LRIW+
Sbjct: 253 EHHEKILNKFLSKLKQHLDS--QEIYTSFYTMKWFFQCFLDRTPFTLNLRIWD 303
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 74.7 bits (182), Expect = 3e-13
Identities = 81/314 (25%), Positives = 136/314 (43%), Gaps = 52/314 (16%)
Query: 419 KAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEY-SEIQQKRLSMTPEEH 477
+ + + GI +R W L Y + + R A +K+KEY + I+ S E H
Sbjct: 216 RRLSWSGIPKPVRPMTWKLLSGYLP--ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVH 273
Query: 478 RAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNV-ESMRRILLNYAVYNPAVGYSQGMSDL 536
+ +R + D+ R + P V E RIL +A+ +PA GY QG++DL
Sbjct: 274 QDTYRQIHI----DIPRMSPEALILQ----PKVTEIFERILFIWAIRHPASGYVQGINDL 325
Query: 537 VAP---------ILAEVLD---------------ESDTFWCFVGLMQNTIFVSSPRDEDM 572
V P I AE +D E+DT+WC L+ + +
Sbjct: 326 VTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGI 385
Query: 573 EKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACW 632
+ ++ L EL+ + ++HL LQ F RW+ RE P +R+W+
Sbjct: 386 QMKVKMLEELVSRIDEQVHRHLDQHEVRYLQ--FAFRWMNNLLMREVPLRCTIRLWDT-- 441
Query: 633 AHYQTD-----YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNL-AMHMNGE---LVL 683
YQ++ +FHL++C A + + +++E++ ++LL NL H + E L+L
Sbjct: 442 --YQSEPDGFSHFHLYVCAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLL 498
Query: 684 RKARSLLYQFRLLP 697
+A L + F P
Sbjct: 499 AEAYRLKFAFADAP 512
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 26/177 (14%)
Query: 511 ESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLD----------ESDTFWCFVGLMQN 560
E + RIL YA NP + Y QGM+++V P+ E+DTF+CF LM
Sbjct: 209 EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAE 268
Query: 561 TI--FVSSPRDED------MEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQ-MLFCHRWL 611
F+ S D MEK L++ V Y + L E ++ F RWL
Sbjct: 269 IRDNFIKSLDDSQCGITYKMEKVYSTLKD----KDVELY---LKLQEQNIKPQFFAFRWL 321
Query: 612 LLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLL 668
L +EF + +RIW++ +A F L +C A++ + + ++E + LL
Sbjct: 322 TLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLL 378
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 62.4 bits (150), Expect = 2e-09
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 21/160 (13%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQK 458
S W+ L E + KL ++ GI ++IRG VW LL + ++L+
Sbjct: 75 SKWMEMLGEWETYKHSSKLIDRVY-KGIPMNIRGPVWSVLLNI----------QEIKLKN 123
Query: 459 RKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILL 518
Y ++++ + H +D DV T RN+ FFR + ILL
Sbjct: 124 PGRYQIMKERGKRSSEHIHH---------IDLDVRTTLRNHVFFRDRYGAKQRELFYILL 174
Query: 519 NYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
Y+ YNP VGY + +S + A L L E D FW V L+
Sbjct: 175 AYSEYNPEVGYCRDLSHITALFLL-YLPEEDAFWALVQLL 213
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 61.6 bits (148), Expect = 3e-09
Identities = 39/144 (27%), Positives = 69/144 (47%), Gaps = 2/144 (1%)
Query: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
++ D+ RT NN+ F + + +RR+LL ++ NP +GY QG++ L A L + +E
Sbjct: 670 IELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEE 729
Query: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQM-LF 606
FWC V +++ TI + + + R L L + + + LG+ + + L
Sbjct: 730 ESAFWCLVAIVE-TIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788
Query: 607 CHRWLLLCFKREFPEAEALRIWEA 630
W L+ F LR+W+A
Sbjct: 789 TFNWFLVVFADSLISNILLRVWDA 812
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+D+ T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDISGTLRKHMFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+D+ T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDISGTLRKHMFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+D+ T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDISGTLRKHMFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 60.5 bits (145), Expect = 6e-09
Identities = 47/163 (28%), Positives = 72/163 (44%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K+ SE Q+ +D+DV T R + FFR +
Sbjct: 132 KEKGKKSSEHIQR-------------------IDRDVSGTLRKHIFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 60.5 bits (145), Expect = 6e-09
Identities = 47/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+DV T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDVSGTLRKHIFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 60.5 bits (145), Expect = 6e-09
Identities = 47/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+DV T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDVSGTLRKHIFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 60.5 bits (145), Expect = 6e-09
Identities = 47/163 (28%), Positives = 71/163 (43%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+DV T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDVSGTLRKHIFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YLPEEDAFWALVQLL 214
>gi|149999613 TBC1 domain family, member 3B [Homo sapiens]
Length = 549
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/163 (27%), Positives = 70/163 (42%), Gaps = 27/163 (16%)
Query: 399 SAWLNHLNELGQVEEEYKLRKAIF---FGGIDVSIRGEVWPFLLRYYSHESTSEEREALR 455
S W++ L + E+YK + + + G+ ++IRG +W LL + + R +
Sbjct: 76 SKWVDMLGDW----EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 456 LQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRR 515
+K K SE Q+ +D+D+ T R + FFR +
Sbjct: 132 KEKGKRSSEHIQR-------------------IDRDISGTLRKHMFFRDRYGTKQRELLH 172
Query: 516 ILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLM 558
ILL Y YNP VGY + +S + A L E D FW V L+
Sbjct: 173 ILLAYEEYNPEVGYCRDLSHIAALFLL-YFPEEDAFWALVQLL 214
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 58.2 bits (139), Expect = 3e-08
Identities = 42/150 (28%), Positives = 70/150 (46%), Gaps = 15/150 (10%)
Query: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
++ D++RT NN+ + + ++ +R +LL ++ NP +GY QG++ LVA L L++
Sbjct: 710 IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL-YLEQ 768
Query: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLL-------YLRELLRLTHVRFYQHLVSLGED 600
D FWC V +++ V PRD K LL R+L+ R + H D
Sbjct: 769 EDAFWCLVTIVE----VFMPRDY-YTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823
Query: 601 GLQMLFCHRWLLLCFKREFPEAEALRIWEA 630
L W L+ F +IW++
Sbjct: 824 --YTLITFNWFLVVFVDSVVSDILFKIWDS 851
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 58.2 bits (139), Expect = 3e-08
Identities = 42/150 (28%), Positives = 70/150 (46%), Gaps = 15/150 (10%)
Query: 488 VDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDE 547
++ D++RT NN+ + + ++ +R +LL ++ NP +GY QG++ LVA L L++
Sbjct: 710 IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL-YLEQ 768
Query: 548 SDTFWCFVGLMQNTIFVSSPRDEDMEKQLL-------YLRELLRLTHVRFYQHLVSLGED 600
D FWC V +++ V PRD K LL R+L+ R + H D
Sbjct: 769 EDAFWCLVTIVE----VFMPRDY-YTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVD 823
Query: 601 GLQMLFCHRWLLLCFKREFPEAEALRIWEA 630
L W L+ F +IW++
Sbjct: 824 --YTLITFNWFLVVFVDSVVSDILFKIWDS 851
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,363,794
Number of Sequences: 37866
Number of extensions: 1744378
Number of successful extensions: 6860
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 6500
Number of HSP's gapped (non-prelim): 412
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.