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Search of human proteins with 33469931
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33469931 EGF-like, fibronectin type III and laminin G
domains isoform 2 [Homo sapiens]
(775 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 1606 0.0
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 1596 0.0
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 774 0.0
gi|54873613 agrin [Homo sapiens] 332 6e-91
gi|33469937 EGF-like, fibronectin type III and laminin G domains... 313 5e-85
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 306 4e-83
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 191 2e-48
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 142 1e-33
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 131 2e-30
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 126 9e-29
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 124 4e-28
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 114 3e-25
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 113 8e-25
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 110 4e-24
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 105 1e-22
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 101 3e-21
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 100 7e-21
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 100 9e-21
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 97 6e-20
gi|188528675 slit homolog 1 [Homo sapiens] 92 1e-18
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 89 2e-17
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 88 3e-17
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 87 5e-17
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 86 1e-16
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 85 2e-16
gi|4759146 slit homolog 2 [Homo sapiens] 84 4e-16
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 81 4e-15
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens] 81 4e-15
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 81 4e-15
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 79 2e-14
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 1606 bits (4159), Expect = 0.0
Identities = 775/775 (100%), Positives = 775/775 (100%)
Query: 1 MHPGPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVES 60
MHPGPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVES
Sbjct: 1 MHPGPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVES 60
Query: 61 KKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSA 120
KKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSA
Sbjct: 61 KKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSA 120
Query: 121 DSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLE 180
DSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLE
Sbjct: 121 DSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLE 180
Query: 181 FRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTV 240
FRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTV
Sbjct: 181 FRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTV 240
Query: 241 MLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGC 300
MLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGC
Sbjct: 241 MLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGC 300
Query: 301 VQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPL 360
VQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPL
Sbjct: 301 VQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPL 360
Query: 361 GFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY 420
GFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY
Sbjct: 361 GFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY 420
Query: 421 DTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQ 480
DTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQ
Sbjct: 421 DTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQ 480
Query: 481 KIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD 540
KIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD
Sbjct: 481 KIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD 540
Query: 541 FTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIG 600
FTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIG
Sbjct: 541 FTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIG 600
Query: 601 RSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV 660
RSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV
Sbjct: 601 RSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALV 660
Query: 661 FSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNING 720
FSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNING
Sbjct: 661 FSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNING 720
Query: 721 ALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
ALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 721 ALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 1596 bits (4133), Expect = 0.0
Identities = 771/771 (100%), Positives = 771/771 (100%)
Query: 5 PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS 64
PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS
Sbjct: 239 PEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMS 298
Query: 65 ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC 124
ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC
Sbjct: 299 ISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFC 358
Query: 125 VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE 184
VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE
Sbjct: 359 VNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAE 418
Query: 185 AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR 244
AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR
Sbjct: 419 AEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYR 478
Query: 245 DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL 304
DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL
Sbjct: 479 DGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSL 538
Query: 305 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 364
AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG
Sbjct: 539 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 598
Query: 365 RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 424
RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS
Sbjct: 599 RHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 658
Query: 425 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 484
KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE
Sbjct: 659 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 718
Query: 485 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 544
GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG
Sbjct: 719 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 778
Query: 545 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 604
VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL
Sbjct: 779 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 838
Query: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN
Sbjct: 839 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 898
Query: 665 LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV 724
LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV
Sbjct: 899 LGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYV 958
Query: 725 GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 959 GGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1009
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 774 bits (1999), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 401 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 460
MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN 60
Query: 461 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 520
WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP
Sbjct: 61 WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP 120
Query: 521 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 580
FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF
Sbjct: 121 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 180
Query: 581 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 640
EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD
Sbjct: 181 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 240
Query: 641 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 700
SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD
Sbjct: 241 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 300
Query: 701 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 760
DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV
Sbjct: 301 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLV 360
Query: 761 EDAVDGKNINTCGAK 775
EDAVDGKNINTCGAK
Sbjct: 361 EDAVDGKNINTCGAK 375
Score = 172 bits (435), Expect = 1e-42
Identities = 117/384 (30%), Positives = 193/384 (50%), Gaps = 28/384 (7%)
Query: 175 FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKL 234
F+IT FR ++ DG+LLY + G DF+S+ + ++FRF+CG+G ++ SE + L
Sbjct: 3 FEIT--FRPDSGDGVLLYSYDT--GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 58
Query: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
G WH + + R NG+LQ++ V G ++G +++I T +++GG P+ + + +G
Sbjct: 59 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 118
Query: 295 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSY 354
+ F G +Q + +N R I ++ SG +V E ++ C A C HGG+C K + Y
Sbjct: 119 KPFSGSIQKIILNDRTIHVK----HDFTSGVNV-ENAAHPCVRAPCAHGGSCRPRK-EGY 172
Query: 355 ICLCPLGFKGRHCEDAF--TLTIPQFRESLRSYAATPWP-----LEPQHYLSFMEFEITF 407
C CPLGF+G HC+ A + IPQF RSY P + FM F+ T
Sbjct: 173 DCDCPLGFEGLHCQKAIIEAIEIPQFIG--RSYLTYDNPDILKRVSGSRSNVFMRFKTTA 230
Query: 408 RPDSGDGVLLYSYDT---GSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHEL 464
+ DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH +
Sbjct: 231 K----DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRV 286
Query: 465 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGS 524
+ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVGC 345
Query: 525 IQKIILN-DRTIHVKHDFTSGVNV 547
I L+ D I + D G N+
Sbjct: 346 ISHFTLSTDYHISLVEDAVDGKNI 369
Score = 95.9 bits (237), Expect = 1e-19
Identities = 78/275 (28%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 69 KTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDY 128
K S ++ P S S+ + + I ++ +GV + + PC C+ C
Sbjct: 112 KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH--PCVRAPCAHGGSCRPRK 169
Query: 129 TWGGSRCQCTLGKGGESCSEDIV--IQYPQFFGHSYVTFEP---LKN-SYQAFQITLEFR 182
G C C LG G C + I+ I+ PQF G SY+T++ LK S + + F+
Sbjct: 170 E--GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 227
Query: 183 AEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVM 241
A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G WH V
Sbjct: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVK 287
Query: 242 LYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN----RGF 297
RDG +G + +++ TG+S G ++ LY+GG A TN RG
Sbjct: 288 AVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQYMRGL 342
Query: 298 QGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 332
GC+ ++ D + A+ G ++ C +
Sbjct: 343 VGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 374
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 332 bits (852), Expect = 6e-91
Identities = 235/764 (30%), Positives = 356/764 (46%), Gaps = 69/764 (9%)
Query: 67 NPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVN 126
+P S+ + T+A+ P T P P + G+ A PCD C C +
Sbjct: 1290 HPSHTSQPVAKTTAA-PTTRRPPTTAPSRVPGRRPPAPQQP--PKPCDSQPCFHGGTCQD 1346
Query: 127 DYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAE 186
GG C C G+GG C + + P F G S++ F L+ +Y ++ LEFRA
Sbjct: 1347 WALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLR-AYHTLRLALEFRALEP 1405
Query: 187 DGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDG 246
GLLLY G N G+ DF++LA++ +Q RF+ G+G A++ S ++ G WH + L R
Sbjct: 1406 QGLLLYNG-NARGK-DFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHW 1463
Query: 247 LNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPS--AYWLVRATGTNRGFQGCVQSL 304
G L ++ TPV G+S + T L++GG P A + T G +GC++ L
Sbjct: 1464 RRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLL 1523
Query: 305 AVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKG 364
VN +R+++ P G A G+ VGEC C C G C ++A + C CP G G
Sbjct: 1524 DVNNQRLELGIGP-GAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVG 1582
Query: 365 RHC----------------------EDAFTLTIPQFRESLRSYAATPWP----------- 391
C E P RE A+
Sbjct: 1583 PTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNG 1642
Query: 392 ---LEPQHYLSF-------MEFEITFRPDSGDGVLLYSYDT--GSKDFLSINLAGGHVEF 439
LE + +F M E+ F G+LLY+ G DF+S+ L +EF
Sbjct: 1643 FSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEF 1702
Query: 440 RFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTD 499
R+D G G V+RS +P+TLG W + + R + G L+V V G + T +
Sbjct: 1703 RYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEP 1762
Query: 500 IFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN-AAHPCVRA- 557
+++GG P++ + + + V F G+IQ + L R + V+V + A HPC RA
Sbjct: 1763 LYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRAS 1822
Query: 558 --PCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEA----IEIPQFIGRSYLTYDNPDI 611
PC +G SC PR+ Y C CP GF G HC+K ++E ++ F GR+++ Y N +
Sbjct: 1823 GHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNA-V 1881
Query: 612 LKRVSGSRSNVF-MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVA 670
+ +SN F + +T A GL+LW G + R +D+++L + DG L SYNLGS
Sbjct: 1882 TESEKALQSNHFELSLRTEATQGLVLWSGKATER--ADYVALAIVDGHLQLSYNLGSQPV 1939
Query: 671 SIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI 730
+ N RW RV A R+ + G + V + TG SP QL+ +GAL++GG+ E+
Sbjct: 1940 VLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPEL 1999
Query: 731 AL--HTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTC 772
+ + Y G VGC+ + + + L+EDAV + C
Sbjct: 2000 PVGPALPKAYGTGFVGCLRDVVVGR-HPLHLLEDAVTKPELRPC 2042
>gi|33469937 EGF-like, fibronectin type III and laminin G domains
isoform 4 [Homo sapiens]
Length = 152
Score = 313 bits (801), Expect = 5e-85
Identities = 152/152 (100%), Positives = 152/152 (100%)
Query: 624 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 683
MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW
Sbjct: 1 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 60
Query: 684 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 743
HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV
Sbjct: 61 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLV 120
Query: 744 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
GCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Sbjct: 121 GCISHFTLSTDYHISLVEDAVDGKNINTCGAK 152
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/159 (29%), Positives = 76/159 (47%), Gaps = 13/159 (8%)
Query: 179 LEFRAEAEDGLLLYCGENE-HGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW 237
+ F+ A+DGLLL+ G++ DF+SL + +L F +N G+GVA I+ G W
Sbjct: 1 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRW 60
Query: 238 HTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN--- 294
H V RDG +G + +++ TG+S G ++ LY+GG A TN
Sbjct: 61 HRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-----ALHTNRQY 115
Query: 295 -RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS 332
RG GC+ ++ D + A+ G ++ C +
Sbjct: 116 MRGLVGCISHFTLS---TDYHISLVEDAVDGKNINTCGA 151
Score = 56.6 bits (135), Expect = 9e-08
Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 5/145 (3%)
Query: 407 FRPDSGDGVLLYSYDTGSK---DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHE 463
F+ + DG+LL+ D+ + DF+S+ L G + F ++ GSG + G WH
Sbjct: 3 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR 62
Query: 464 LRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSG 523
++ R ++G + VD G + G Q+ N +++GG+ + N ++ G
Sbjct: 63 VKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEI-ALHTNRQYMRGLVG 121
Query: 524 SIQKIILN-DRTIHVKHDFTSGVNV 547
I L+ D I + D G N+
Sbjct: 122 CISHFTLSTDYHISLVEDAVDGKNI 146
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 306 bits (785), Expect = 4e-83
Identities = 205/711 (28%), Positives = 319/711 (44%), Gaps = 121/711 (17%)
Query: 151 VIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENE---------HGRG 201
V+ Y +S++ +K++Y+ F+I + FR ++ DG+LLY G+ + +
Sbjct: 3662 VVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP 3721
Query: 202 DFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTG 261
DF+S ++ +FRF+ G+G+A I T + LG +HTV L R G L + + PV G
Sbjct: 3722 DFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
Query: 262 QSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKA 321
SQG++ + LYLGG P Y + G + GF GCV+ L + G I L
Sbjct: 3782 TSQGKFQGLDLNEELYLGGYPD-YGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNL--- 3837
Query: 322 LSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE------------- 368
+ + C + C + C +GG C ++ SY+C+CP GF G CE
Sbjct: 3838 -TAHGISHCPT--CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACG 3894
Query: 369 ----------------------------DAFTLTIPQFRESLRSYAATPWPLEPQHYLSF 400
+ T+T P SY A P H L
Sbjct: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSL-SGAGSYLALPALTNTHHEL-- 3951
Query: 401 MEFEITFRPDSGDGVLLYSYDTGS--KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 458
++ F+P + DGVLL+S +DF+S+ + GGH+EFR++ GSG VLRS +PL L
Sbjct: 3952 -RLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL 4010
Query: 459 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 518
G WH + R K+G L+V+ + V + G + +T +++GGV + + +
Sbjct: 4011 GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
Query: 519 KPFSGSIQKIILNDRTIHVKHDF--TSGVNVENAAHPCVRAPCAHGGSCRPRKE------ 570
F G + ++ +N + + + + F + G+ + PC R PC HG +C P E
Sbjct: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
Query: 571 ------------------------------GYDCDCPLGFEGLHCQKAIIEAI------- 593
G C C GF G CQ+ I
Sbjct: 4131 CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHL 4190
Query: 594 ------EIPQFIGR-----SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDS- 641
+ P G +L + + + + + +T+ GLLLW+G
Sbjct: 4191 EGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEV 4250
Query: 642 -PMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 700
DFISLGL+DG LVF Y LGSG A ++ NDG WHRV A+R+G+ G I VD
Sbjct: 4251 GEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVD 4310
Query: 701 DYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
+G+SPG +N G++Y+GG ++A T ++ G+ GC+ + L
Sbjct: 4311 GEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
Score = 216 bits (549), Expect = 8e-56
Identities = 149/514 (28%), Positives = 231/514 (44%), Gaps = 84/514 (16%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGH-SYVTFEPLKNS 171
C C D+ CVN G C+C LG+ G C E + + P G SY+ L N+
Sbjct: 3888 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT 3947
Query: 172 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 231
+ ++ +EF+ A DG+LL+ G DF+SLA++ L+FR+ G+G+A++ S
Sbjct: 3948 HHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEP 4007
Query: 232 IKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRAT 291
+ LG WH V R +G L++N G PV S G+ + T LYLGG + L AT
Sbjct: 4008 LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPAT 4067
Query: 292 GTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC-SSGICDEASCIHGGTCTAIK 350
+ F+GCV ++VNG+R+D+ LG +G+C S C+ C HG TC
Sbjct: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLG----SQGIGQCYDSSPCERQPCQHGATCMPAG 4123
Query: 351 ADSYICLCPLGFKGRHCE-------------------DAFTLTIPQF------RESLRSY 385
+ CLC GFKG CE L +P F + S
Sbjct: 4124 EYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGI 4183
Query: 386 AATPWPLE-------PQHYLSFME----------------------FEITFRPDSGDGVL 416
A + W LE P Y ++ E+ R + G+L
Sbjct: 4184 AESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLL 4243
Query: 417 LY-SYDTG----SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAK 471
L+ + G KDF+S+ L GH+ FR+ GSG L SEDP+ G WH + R +
Sbjct: 4244 LWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGR 4303
Query: 472 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV---KKNSGVLKPFSGSIQKI 528
G +QVD +++V G + G + ++IGG P+ + + +SG+ +G ++ +
Sbjct: 4304 RGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGI----TGCVKNL 4359
Query: 529 ILND--------RTIHVKHDFTSGVNVENAAHPC 554
+L+ + + ++H +G N PC
Sbjct: 4360 VLHSARPGAPPPQPLDLQHRAQAGAN----TRPC 4389
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/254 (29%), Positives = 109/254 (42%), Gaps = 40/254 (15%)
Query: 114 DETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSE-------------------DIVIQY 154
+E C C++ T G+RC C G G C + D QY
Sbjct: 4143 EENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQY 4202
Query: 155 PQFF---------GHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCG--ENEHGRG-D 202
+F GH + P I LE R GLLL+ G E G+G D
Sbjct: 4203 GAYFHDDGFLAFPGHVFSRSLPEVPE----TIELEVRTSTASGLLLWQGVEVGEAGQGKD 4258
Query: 203 FMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ 262
F+SL + L FR+ G+G A +VSE I G WH V R+G G +Q++ V+G+
Sbjct: 4259 FISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGR 4318
Query: 263 SQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLG-- 319
S G + + +Y+GGAP L ++ G GCV++L ++ R P PL
Sbjct: 4319 SPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS-GITGCVKNLVLHSARPGAPPPQPLDLQ 4377
Query: 320 -KALSGADVGECSS 332
+A +GA+ C S
Sbjct: 4378 HRAQAGANTRPCPS 4391
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 191 bits (486), Expect = 2e-48
Identities = 178/749 (23%), Positives = 312/749 (41%), Gaps = 126/749 (16%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQF-----FGH-SYVTFE 166
C+ C + CV + C C G+ G C++ I I P+F FG+ S++ +
Sbjct: 2375 CENNPCGNGATCVPK-SGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYS 2433
Query: 167 PLKNSYQAFQITLEFR-----AEAEDGLLLYCGENEHGRG--DFMSLAIIRRSLQFRFNC 219
+ + ++ L+F+ + ++ L+ + G+ HG DF+++ ++ S+ + +N
Sbjct: 2434 RISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNL 2493
Query: 220 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 279
G+G+A I SE G HTV L + G L++++ + + G+ + + Y+G
Sbjct: 2494 GSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVG 2553
Query: 280 GAPSAYW---LVRATGTNRGFQGCVQSLAVNGRRIDMRPW---PLGKALSGADVGECSSG 333
G S Y L GFQGC+ +L V + P G +G VG+C +
Sbjct: 2554 GY-SEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHAS 2612
Query: 334 ICDEASCIHGGTC----------------------TAIKAD------------------- 352
C C +GGTC T D
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP 2672
Query: 353 -SYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDS 411
Y C CPLG G +CE A +++ P FR + S+ + H ++ F+P +
Sbjct: 2673 HGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMS----FASFHVRKKTHIQLQFQPLA 2728
Query: 412 GDGVLLYS---YDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL--GNWHELRV 466
DG+L Y+ S DFL I+L V+ R++ G T +L + +T+ WH ++
Sbjct: 2729 ADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKA 2788
Query: 467 SRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP--FSGS 524
R G L +D + E A + + NTD +IGGV + + V + +P F G
Sbjct: 2789 GRVGAEGYLDLDGINVTE-KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGC 2847
Query: 525 IQKIILNDRTIHVKHDFTSG---------------------------------------V 545
I+++I+N++ + + G
Sbjct: 2848 IRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAG 2907
Query: 546 NVENAAHPCVRAPCAHGGSCRPRKE-GYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 604
N N + C+ C H C P + Y C C LG+ G +C+ + +F+G SY+
Sbjct: 2908 NTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK--TSFSTAKFMGNSYI 2965
Query: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
Y +P+ R + + + + F TT +GL++W G + N DF+++GL + L + N
Sbjct: 2966 KYIDPNYRMR-NLQFTTISLNFSTTKTEGLIVWMGIAQNEEN-DFLAIGLHNQTLKIAVN 3023
Query: 665 LGSGVASIMV--NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR--QLNING 720
LG ++ M NG+F +WH V +++ K +++ + LN +G
Sbjct: 3024 LGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDG 3083
Query: 721 ALYVGGM---KEIALHTNRQYMRGLVGCI 746
Y+GG +++ + T + VG I
Sbjct: 3084 ICYLGGFEYGRKVNIVTQEIFKTNFVGKI 3112
Score = 157 bits (397), Expect = 4e-38
Identities = 180/841 (21%), Positives = 324/841 (38%), Gaps = 151/841 (17%)
Query: 61 KKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSA 120
K I+N ++ ++ PT++ + + V + VA S C + +C
Sbjct: 2056 KNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPS-----VCQQDVCHN 2110
Query: 121 DSFCVNDYTWGGS---RCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLK-----NSY 172
C + G +C C L G C +D + +P F G+SY+ LK
Sbjct: 2111 GGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHN 2170
Query: 173 QAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKI 232
+ I L + + +G +LY N G+ F+ L ++ ++ CG I+
Sbjct: 2171 RTVTIYLTIKTNSLNGTILYSNGNNCGK-QFLHLFLVEGRPSVKYGCGNSQNILTVSANY 2229
Query: 233 KLGG--------WHTVMLYRDGLNGLLQLN-NGTPVTGQSQGQYSKIT--FRTPLYLGGA 281
+ +T + G+ ++++ +G P + + S + + ++LG
Sbjct: 2230 SINTNAFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHI 2289
Query: 282 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC----------- 330
P+ + + G GF+GC+ L VN + + + +A G ++ C
Sbjct: 2290 PANVQIHKKAGPVYGFRGCILDLQVNNKEFFI----IDEARHGKNIENCHVPWCAHHLCR 2345
Query: 331 --------------------SSGICDEASCIH-----GGTCTAIKADSYICLCPLGFKGR 365
S +C ASC + G TC +CLCP G G
Sbjct: 2346 NNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGP 2405
Query: 366 HCEDAFTLTIPQFRESLRSYAATPWPLEPQ------HYLSFMEFEITFRPDSGDGVLLY- 418
C DA +T P+F ++ T + + HY ++F++ + L++
Sbjct: 2406 LCTDAINITQPRF-SGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFF 2464
Query: 419 ----SYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLG-NWHELRVSRTAKNG 473
+ DFL++ L G V + ++ GSG +RSE PL L H + + + + G
Sbjct: 2465 TGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSE-PLNLSLGVHTVHLGKFFQEG 2523
Query: 474 ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNY-DDVKKNSGVLK-PFSGSIQKI-IL 530
L+VD K +A G + + ++GG Y D+ N K F G I + +
Sbjct: 2524 WLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVR 2583
Query: 531 NDRTIHVK-------HDFTSGVNVENAAHPCVRAPCAHGG-------------------- 563
++ H + H + A PC C +GG
Sbjct: 2584 TEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGS 2643
Query: 564 -------SCRPRKE----------------GYDCDCPLGFEGLHCQKAIIEAIEIPQFIG 600
+C P + GY C CPLG G++C++A+ +I P F
Sbjct: 2644 FCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQAL--SISDPSFRS 2701
Query: 601 R--SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGA 658
S++++ + + K ++++ ++F+ A DG+L + + DF+ + L + +
Sbjct: 2702 NELSWMSFASFHVRK-----KTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSS 2756
Query: 659 LVFSYNLGSG--VASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL 716
+ YNLG + + + N WH +KA R G G + +D T K+ M L
Sbjct: 2757 VQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINV-TEKASTKMSSL 2815
Query: 717 NINGALYVGGMKEIALHTNRQYMR----GLVGCISHFTLSTDYHISLVE-DAVDGKNINT 771
+ N Y+GG+ + L N + G GCI ++ + + L E A G N+
Sbjct: 2816 DTNTDFYIGGVSSLNL-VNPMAIENEPVGFQGCIRQVIIN-NQELQLTEFGAKGGSNVGD 2873
Query: 772 C 772
C
Sbjct: 2874 C 2874
Score = 152 bits (383), Expect = 1e-36
Identities = 170/700 (24%), Positives = 281/700 (40%), Gaps = 110/700 (15%)
Query: 156 QFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEH-GRGDFMSLAIIRRSLQ 214
+++G SY+ F+ + + Q I+LEF+ + GLLLY ++ + G F+ L I +L+
Sbjct: 1887 RYYGDSYLEFQNVALNPQN-NISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLK 1945
Query: 215 FRFNCGTGVAIIVSETKIKL-GGWHTVMLYRDGLNG----LLQLNNGTPVTGQSQGQYSK 269
+ F C T +++ G +L R L+ L L T + K
Sbjct: 1946 YHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGK 2005
Query: 270 ITFRT-PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM--------------- 313
++ +++GG P + ++ + F GC++ + +N R +
Sbjct: 2006 PLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRS 2065
Query: 314 RPWPLGKALSGADVGECSSGI----------------CDEASCIHGGTCTAIKADSYI-- 355
+ + L S D + + G+ C + C +GGTC AI S I
Sbjct: 2066 QGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVS 2125
Query: 356 --CLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW---PLEPQHYLSFMEFEITFRPD 410
C CPL F GR CE L P F + SY P+ LE +H + + +T + +
Sbjct: 2126 FQCDCPLHFTGRFCEKDAGLFFPSFNGN--SYLELPFLKFVLEKEHNRTVTIY-LTIKTN 2182
Query: 411 SGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRT 469
S +G +LYS K FL + L G ++ CG+ +L ++ ++
Sbjct: 2183 SLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIR 2242
Query: 470 AKNGILQVDKQKIVEGMAEGGFTQIKCNTDI-----------FIGGVPNYDDVKKNSGVL 518
+ ++E A+G K +T+I F+G +P + K +G +
Sbjct: 2243 YTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPV 2302
Query: 519 KPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGSCRPRKEGYDCDCP 577
F G I + +N++ + + G N+EN P C C + G+C E C+CP
Sbjct: 2303 YGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECP 2362
Query: 578 LGFEGLHCQKAIIE---------------------------------AIEI--PQFIGRS 602
+ G CQ A E AI I P+F G
Sbjct: 2363 RLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTD 2422
Query: 603 YLTYDNPDILKRVSGSRSNVFMRFK-------TTAKDGLLLWRGDSPMRPN-SDFISLGL 654
Y + R+S + K + ++ L+ + G N DF+++GL
Sbjct: 2423 AFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGL 2482
Query: 655 RDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMR 714
+G++V+SYNLGSG+ASI H V + Q G + VDD+ ++ +PG +
Sbjct: 2483 LNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLV 2542
Query: 715 QLNINGALYVGGMKEIA---LHTNRQYMRGLVGCISHFTL 751
LN+ YVGG E L + G GCI FTL
Sbjct: 2543 GLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCI--FTL 2580
Score = 53.1 bits (126), Expect = 9e-07
Identities = 67/287 (23%), Positives = 94/287 (32%), Gaps = 38/287 (13%)
Query: 323 SGADVGECSSGI--CDEASCIHGGTC-TAIKADSYICLCPLGFKGRHCEDAFTLTIPQFR 379
SG CS I CD C++GG C + ++CLCP + G+ C + L
Sbjct: 799 SGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHN 858
Query: 380 ESLRSYAATPWPLEPQHYLSFMEFE-ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE 438
+ QH + EFE D D + L D G + + N
Sbjct: 859 PCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNN------- 911
Query: 439 FRFDCGSGTGVLRSEDPLTLGNWHELRV----SRTAKNGILQVDKQKIVEGMAEGGFTQI 494
FR C G G+ E+ + S KN VD E +
Sbjct: 912 FRCICRPGFS----------GSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGP 961
Query: 495 KCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC 554
C D+ N + P + D + +G+N E C
Sbjct: 962 FCELDV-------------NKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDEC 1008
Query: 555 VRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR 601
+ PC H G C Y CDC GF G HC+ + + P GR
Sbjct: 1009 LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR 1055
Score = 42.0 bits (97), Expect = 0.002
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE 594
C PC + G C+ G+ C CP G+ G +C+K+I E
Sbjct: 1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAE 1123
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/47 (36%), Positives = 22/47 (46%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 589
SG E + C +PC HG C GY C C G+ G HC+ +
Sbjct: 1154 SGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL 1200
Score = 39.3 bits (90), Expect = 0.014
Identities = 36/148 (24%), Positives = 55/148 (37%), Gaps = 35/148 (23%)
Query: 467 SRTAKNGILQVDKQ-----------KIVEG---MAEGGFTQIKCNTDIFIGGVPNYDDVK 512
S KNG +D+ K+V+G + G+ I+C DI DD
Sbjct: 687 SHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDI--------DDCI 738
Query: 513 KNS----GVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPR 568
N+ K S Q + L+D G E ++ C PC + +C
Sbjct: 739 LNACEHNSTCKDLHLSYQCVCLSD---------WEGNFCEQESNECKMNPCKNNSTCTDL 789
Query: 569 KEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
+ Y C+C G+ G +C + I E P
Sbjct: 790 YKSYRCECTSGWTGQNCSEEINECDSDP 817
Score = 37.4 bits (85), Expect = 0.053
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 6/44 (13%)
Query: 326 DVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCED 369
++ ECSS + C+HG C + Y+C C G+ G HCE+
Sbjct: 1161 NINECSS-----SPCLHGADCED-HINGYVCKCQPGWSGHHCEN 1198
Score = 34.7 bits (78), Expect = 0.35
Identities = 38/196 (19%), Positives = 83/196 (42%), Gaps = 17/196 (8%)
Query: 586 QKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRP 645
Q+ +I ++ G SYL + N + ++N+ + F+T + GLLL+
Sbjct: 1876 QRLMISDFSCVRYYGDSYLEFQNVAL-----NPQNNISLEFQTFSSYGLLLYVKQDSNLV 1930
Query: 646 NSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHR----VKAVRDGQSGKITVDD 701
+ FI L + +G L + + +N + + ++ D + ++T+
Sbjct: 1931 DGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELTILG 1990
Query: 702 YGARTGKSPG--MMRQLNINGALYVGGMKEIALHTNRQY---MRGLVGCISHFTLSTDYH 756
+ +S + + L +G++++GG + LH Q ++ GCI ++ ++
Sbjct: 1991 RNTQICESINHVLGKPLPKSGSVFIGGFPD--LHGKIQMPVPVKNFTGCIEVIEIN-NWR 2047
Query: 757 ISLVEDAVDGKNINTC 772
+ AV +IN C
Sbjct: 2048 SFIPSKAVKNYHINNC 2063
Score = 33.5 bits (75), Expect = 0.77
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 300 CVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI--CDEASCIHGGTCTAIKADSYIC 356
C+ + ++GR ++ +P G +C I C C++ G C A + C
Sbjct: 1046 CLSNPCLHGRCTELINEYPCSCDADGTST-QCKIKINDCTSIPCMNEGFCQK-SAHGFTC 1103
Query: 357 LCPLGFKGRHCE 368
+CP G+ G +CE
Sbjct: 1104 ICPRGYTGAYCE 1115
Score = 33.1 bits (74), Expect = 1.0
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 333 GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
G C C HG C+ I ++S+IC C F G CE
Sbjct: 258 GQCQPHVCFHGN-CSNITSNSFICECDEQFSGPFCE 292
Score = 32.3 bits (72), Expect = 1.7
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDI 150
C C +S C + Y RC+CT G G++CSE+I
Sbjct: 775 CKMNPCKNNSTCTDLYK--SYRCECTSGWTGQNCSEEI 810
Score = 32.3 bits (72), Expect = 1.7
Identities = 12/42 (28%), Positives = 20/42 (47%)
Query: 327 VGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
+ C+ + C++GG C ++ C C GF G+ CE
Sbjct: 1118 IDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCE 1159
Score = 31.6 bits (70), Expect = 2.9
Identities = 12/36 (33%), Positives = 19/36 (52%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 589
C P + +C+ ++ Y C C GF +C+KAI
Sbjct: 374 CESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
Score = 30.0 bits (66), Expect = 8.5
Identities = 14/41 (34%), Positives = 20/41 (48%), Gaps = 5/41 (12%)
Query: 554 CVRAPCAHGGSCRPRKE-----GYDCDCPLGFEGLHCQKAI 589
C PC + GSC ++E Y+C C F G +C + I
Sbjct: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEII 257
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 142 bits (358), Expect = 1e-33
Identities = 145/527 (27%), Positives = 209/527 (39%), Gaps = 84/527 (15%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 172
C +C CVN GG +C C G + + +P HS++TF L+ +
Sbjct: 1332 CTPGVCKNGGTCVNLLV-GGFKCDCPSGDFEKPYCQVTTRSFP---AHSFITFRGLRQRF 1387
Query: 173 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 231
F + L F + DGLLLY G NE + DF++L +I+ +Q F+ G +
Sbjct: 1388 H-FTLALSFATKERDGLLLYNGRFNE--KHDFVALEVIQEQVQLTFSAGESTTTVSPFVP 1444
Query: 232 --IKLGGWHTVML--YRDGLNGLLQLNNGTP----------------------------- 258
+ G WHTV L Y L G L G
Sbjct: 1445 GGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSC 1504
Query: 259 -VTGQSQGQYSKITFRTPLYLGGAPSA--YWLVRATGTNRGFQGCVQSLAVNGRRIDMRP 315
G G + PL LGG P + VR R F GC+++L V+ R IDM
Sbjct: 1505 AAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRM----RQFVGCMRNLQVDSRHIDMAD 1560
Query: 316 WPLGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLT 374
+ A +G G +CD +C +GGTC + D++ C CPLGF G+ C
Sbjct: 1561 FI---ANNGTVPGCPAKKNVCDSNTCHNGGTCVN-QWDAFSCECPLGFGGKSCAQEMANP 1616
Query: 375 IPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAG 434
SL ++ P+ YLS M FR DGVLL + G + +++ L
Sbjct: 1617 QHFLGSSLVAWHGLSLPISQPWYLSLM-----FRTRQADGVLLQAITRG-RSTITLQLRE 1670
Query: 435 GHVEFRFDCGSGTGVLRSEDPL-----TLGNWHELRVSRTAKNG----ILQVD-KQKIVE 484
GHV + GTG+ S L G+WH +++ A G IL D Q+ E
Sbjct: 1671 GHVMLSVE---GTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAE 1727
Query: 485 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH---DF 541
G + ++I +GG+P GV + F G +Q + ++D V
Sbjct: 1728 GNLGPRLHGLHL-SNITVGGIPG-----PAGGVARGFRGCLQGVRVSDTPEGVNSLDPSH 1781
Query: 542 TSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHC 585
+NVE PC PC C + Y C C G+ G +C
Sbjct: 1782 GESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNC 1828
Score = 82.0 bits (201), Expect = 2e-15
Identities = 111/487 (22%), Positives = 190/487 (39%), Gaps = 77/487 (15%)
Query: 332 SGICDEASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAATPW 390
SG C C +GGTC + + C CP G F+ +C+ T + P S+
Sbjct: 1329 SGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ-VTTRSFPA-----HSFITFRG 1382
Query: 391 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGSGTGV 449
+ H+ + F R DG+LLY+ K DF+++ + V+ F G T
Sbjct: 1383 LRQRFHFTLALSFATKER----DGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTT 1438
Query: 450 LRSEDP--LTLGNWHELRVSRTAKNGILQV------DKQKIV------------------ 483
+ P ++ G WH +++ K + Q +QK+
Sbjct: 1439 VSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSV 1498
Query: 484 --------EGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV-LKPFSGSIQKIILNDRT 534
+G G + + +GGVP D+ ++ V ++ F G ++ + ++ R
Sbjct: 1499 LGNYSCAAQGTQGGSKKSLDLTGPLLLGGVP---DLPESFPVRMRQFVGCMRNLQVDSRH 1555
Query: 535 IHVKHDFTSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 591
I + + V + C C +GG+C + + + C+CPLGF G C + E
Sbjct: 1556 IDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQ---E 1612
Query: 592 AIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFIS 651
F+G S + + L + + F+T DG+LL + I+
Sbjct: 1613 MANPQHFLGSSLVAWHG---LSLPISQPWYLSLMFRTRQADGVLL----QAITRGRSTIT 1665
Query: 652 LGLRDGALVFSYNLGSGVASIMVN---GSFNDGRWHRVKAVRDGQSG---KITVDDYGAR 705
L LR+G ++ S G+G+ + + G NDG WH + G I DYG +
Sbjct: 1666 LQLREGHVMLSVE-GTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQ 1724
Query: 706 --TGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDA 763
G + L+++ + VGG+ A RG GC+ +S D
Sbjct: 1725 RAEGNLGPRLHGLHLSN-ITVGGIPGPA----GGVARGFRGCLQGVRVSDTPEGVNSLDP 1779
Query: 764 VDGKNIN 770
G++IN
Sbjct: 1780 SHGESIN 1786
Score = 67.8 bits (164), Expect = 4e-11
Identities = 79/312 (25%), Positives = 112/312 (35%), Gaps = 60/312 (19%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQ-FFGHSYVTFEPLKNS 171
CD C CVN W C+C LG GG+SC++++ PQ F G S V + L
Sbjct: 1578 CDSNTCHNGGTCVNQ--WDAFSCECPLGFGGKSCAQEMA--NPQHFLGSSLVAWHGLSLP 1633
Query: 172 Y-QAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV---AIIV 227
Q + ++L FR DG+LL RG +R GTG+ ++ +
Sbjct: 1634 ISQPWYLSLMFRTRQADGVLL----QAITRGRSTITLQLREGHVMLSVEGTGLQASSLRL 1689
Query: 228 SETKIKLGGWHTVMLYRDGLNG----LLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 283
+ G WH L G +L + G + G + + +GG P
Sbjct: 1690 EPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPG 1749
Query: 284 AYWLVRATGTNRGFQGCVQSLAV-------------NGRRI------------DMRPWPL 318
A G RGF+GC+Q + V +G I D P P
Sbjct: 1750 P-----AGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPA 1804
Query: 319 GKALSGA-DVGECS----------SGICDEASCIHGGTCTAIKA--DSYICLCPLGFKGR 365
S D CS + +CD C H CT + Y C CP + G
Sbjct: 1805 NSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGP 1864
Query: 366 HCEDAFTLTIPQ 377
+CE P+
Sbjct: 1865 YCETRIDQPCPR 1876
Score = 57.8 bits (138), Expect = 4e-08
Identities = 66/298 (22%), Positives = 107/298 (35%), Gaps = 69/298 (23%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP------ 596
+G E C PC G CR R+ GY C C G+ G HC+ + P
Sbjct: 1281 TGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNG 1340
Query: 597 -------------------------QFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAK 631
Q RS+ + + + F T +
Sbjct: 1341 GTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKER 1400
Query: 632 DGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI--MVNGSFNDGRWHRVKAV 689
DGLLL+ G DF++L + + +++ G ++ V G +DG+WH V+
Sbjct: 1401 DGLLLYNG--RFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLK 1458
Query: 690 RD-----GQSG-----------KITVD--DYG--------------ARTGKSPGMMRQLN 717
GQ+G +TVD D G A G G + L+
Sbjct: 1459 YYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLD 1518
Query: 718 INGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 775
+ G L +GG+ ++ + MR VGC+ + + + HI + + + + C AK
Sbjct: 1519 LTGPLLLGGVPDLP-ESFPVRMRQFVGCMRNLQVDS-RHIDMADFIANNGTVPGCPAK 1574
Score = 37.7 bits (86), Expect = 0.041
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 112 PCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCS 147
PCD C A+S+C ND W C C G G++C+
Sbjct: 1796 PCDSNPCPANSYCSND--WDSYSCSCDPGYYGDNCT 1829
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 131 bits (330), Expect = 2e-30
Identities = 163/761 (21%), Positives = 311/761 (40%), Gaps = 137/761 (18%)
Query: 72 SRLIPPTSASLPVTTVAPQ-----PIPIQRKGKNGVAIMSRLFDMPCDETLC--SADSFC 124
S+++P S + + P P +G+ GV + + + D+ +C S F
Sbjct: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFR 251
Query: 125 VNDYTWGGSRCQ----CTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QIT 178
D + + + +G G+S ++ I F G Y ++ +N Q+ +IT
Sbjct: 252 GKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEIT 309
Query: 179 LEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLG 235
L F+ +GL+L+ G++ D+++LA+ ++ N G+G + E K
Sbjct: 310 LSFKTLQRNGLMLHTGKS----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
Query: 236 GWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWL 287
WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+PS L
Sbjct: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
Query: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
+ +N F GC++ + + + L K D IHG
Sbjct: 426 PGSPVSNN-FMGCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VV 469
Query: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEIT 406
A K ++ L P+ F E+ S+ + P W + +SF
Sbjct: 470 AFKCENVATLDPITF-----------------ETPESFISLPKWNAKKTGSISF-----D 507
Query: 407 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 453
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
Query: 454 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 513
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
Query: 514 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 555
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
Query: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 614
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
Query: 615 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 665
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
Query: 666 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 725
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
Query: 726 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 762
E + T R+Y+ + +G + T + +I L ++
Sbjct: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
Score = 121 bits (304), Expect = 2e-27
Identities = 152/650 (23%), Positives = 256/650 (39%), Gaps = 101/650 (15%)
Query: 112 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 169
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 679 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 734
Query: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 222
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 735 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
Query: 223 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 274
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 795 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 854
Query: 275 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 334
YL PS F G +QSL NG A + C +G
Sbjct: 855 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 887
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
D I AD P+ FK + A +L++Y +
Sbjct: 888 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 926
Query: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 452
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 927 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 979
Query: 453 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 509
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 980 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1037
Query: 510 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 564
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 1038 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1097
Query: 565 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 623
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 1098 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1153
Query: 624 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 682
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 1154 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1211
Query: 683 WHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 729
+H V+ R G + + VD + G RQL N + +GG ++
Sbjct: 1212 YHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
Score = 105 bits (262), Expect = 2e-22
Identities = 102/382 (26%), Positives = 161/382 (42%), Gaps = 33/382 (8%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 914 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 969
Query: 221 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 970 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1028
Query: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 1029 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1085
Query: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 1086 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1141
Query: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 450
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 1142 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1201
Query: 451 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPNYD 509
S + G +H +R +R+ N LQVD ++E G T I IGG
Sbjct: 1202 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG----- 1256
Query: 510 DVKKNSGVLKPFSGSIQKIILN 531
K G +PF G + + N
Sbjct: 1257 ---KEQG--QPFQGQLSGLYYN 1273
Score = 103 bits (256), Expect = 8e-22
Identities = 109/404 (26%), Positives = 164/404 (40%), Gaps = 73/404 (18%)
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 455
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
Query: 456 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 515
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
Query: 516 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 555
LK PF G I+ + +N + VK D + G + A
Sbjct: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
Query: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKA--IIEAIE----------------IP 596
C +GG C + CDC GF G C + +E + I
Sbjct: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA 284
Query: 597 QFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 653
F G Y YD NP + S + + FKT ++GL+L G S +D+++L
Sbjct: 285 TFKGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLA 334
Query: 654 LRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRD--GQSG------KITVDDY 702
L++GA+ NLGSG + VNG FND WH VK R+ SG I+VD
Sbjct: 335 LKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGI 394
Query: 703 GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 746
TG + L + YVGG A +GC+
Sbjct: 395 LTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
Score = 102 bits (253), Expect = 2e-21
Identities = 145/627 (23%), Positives = 259/627 (41%), Gaps = 114/627 (18%)
Query: 167 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 223
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 282
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
Query: 283 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 327
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
Query: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------AFTLTIPQF 378
GE G C++GG C+ + D +C C GF+G+ C A + Q
Sbjct: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQG 274
Query: 379 R-ESLRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFL 428
+ + Y AT E Y S E ++F+ +G++L+ TG S D++
Sbjct: 275 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH---TGKSADYV 331
Query: 429 SINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAK--NGI------LQV 477
++ L G V + GSG E N WH+++V+R + +GI + V
Sbjct: 332 NLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISV 391
Query: 478 DKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHV 537
D G + +T + + ++GG P+ D+ S V F G +++++ + + +
Sbjct: 392 DGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL-PGSPVSNNFMGCLKEVVYKNNDVRL 450
Query: 538 KHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQ 597
+ R K+G D + G+ K A P
Sbjct: 451 E-------------------------LSRLAKQG---DPKMKIHGVVAFKCENVATLDP- 481
Query: 598 FIGRSYLTYDNPD----ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS------ 647
+T++ P+ + K + ++ F+TT +GL+L+ P
Sbjct: 482 ------ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQM 535
Query: 648 ---DFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYG 703
DF ++ + DG L ++GSG I + NDG W+ V RDG+SG I+V+
Sbjct: 536 IKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT-- 593
Query: 704 ARTG-KSPGMMRQLNINGALYVGGMKE 729
RT +PG L+++ LY+GG+ E
Sbjct: 594 LRTPYTAPGESEILDLDDELYLGGLPE 620
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 126 bits (316), Expect = 9e-29
Identities = 151/690 (21%), Positives = 284/690 (41%), Gaps = 133/690 (19%)
Query: 139 LGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGEN 196
+G G+S ++ I F G Y ++ +N Q+ +ITL F+ +GL+L+ G++
Sbjct: 303 MGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
Query: 197 EHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD-------- 245
D+++LA+ ++ N G+G + E K WH V + R+
Sbjct: 361 ----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG 416
Query: 246 --GLNGL-----LQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQ 298
+N L + ++ TG +Q Y+ + Y+GG+PS L + +N F
Sbjct: 417 HAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNN-FM 475
Query: 299 GCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLC 358
GC++ + + + L K D IHG A K ++ L
Sbjct: 476 GCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VVAFKCENVATLD 520
Query: 359 PLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLL 417
P+ F E+ S+ + P W + +SF FR +G++L
Sbjct: 521 PITF-----------------ETPESFISLPKWNAKKTGSISF-----DFRTTEPNGLIL 558
Query: 418 YSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE-DPLTLGNWHEL 464
+S+ DF +I + GH+ D GSGT +++ + G W+ +
Sbjct: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHV 618
Query: 465 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP---- 520
R ++G + V+ + A G + + ++++GG+P + +G++ P
Sbjct: 619 DFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----ENKAGLVFPTEVW 672
Query: 521 -------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCVRAPCAHGGSCR 566
+ G I+ + ++ ++ ++ T+GV + A PC+ PC + G CR
Sbjct: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
Query: 567 PRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMR 625
Y CDC G+ G C++ + + G ++ P ++ + +V +R
Sbjct: 733 DGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHTEA---EDVSLR 785
Query: 626 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GSGVASIMVNG 676
F++ G+L+ + R ++D + L L G + + NL G ++
Sbjct: 786 FRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY 842
Query: 677 SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNR 736
+ ND WH V+ VR G+S K+TVDD A TG+ G +L + E + T R
Sbjct: 843 NLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI-------ETGIITER 895
Query: 737 QYMRGL----VGCISHFTLSTDYHISLVED 762
+Y+ + +G + T + +I L ++
Sbjct: 896 RYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
Score = 120 bits (301), Expect = 5e-27
Identities = 145/620 (23%), Positives = 245/620 (39%), Gaps = 96/620 (15%)
Query: 112 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 169
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 719 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 774
Query: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 222
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 775 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
Query: 223 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 274
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 835 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 894
Query: 275 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 334
YL PS F G +QSL NG A + C +G
Sbjct: 895 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 927
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
D I AD P+ FK + A +L++Y +
Sbjct: 928 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 966
Query: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 452
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 967 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 1019
Query: 453 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 509
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 1020 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1077
Query: 510 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 564
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 1078 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1137
Query: 565 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 623
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 1138 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1193
Query: 624 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 682
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 1194 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1251
Query: 683 WHRVKAVRDGQSGKITVDDY 702
+H V+ R G + + VD +
Sbjct: 1252 YHVVRFTRSGGNATLQVDSW 1271
Score = 101 bits (251), Expect = 3e-21
Identities = 91/339 (26%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 954 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 1009
Query: 221 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 1010 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1068
Query: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 1069 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1125
Query: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 1126 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1181
Query: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 450
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 1182 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1241
Query: 451 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG 489
S + G +H +R +R+ N LQVD ++E G
Sbjct: 1242 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG 1280
Score = 90.9 bits (224), Expect = 4e-18
Identities = 108/444 (24%), Positives = 164/444 (36%), Gaps = 113/444 (25%)
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 455
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
Query: 456 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 515
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
Query: 516 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 555
LK PF G I+ + +N + VK D + G + A
Sbjct: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
Query: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE-------------------- 594
C +GG C + CDC GF G C + I ++
Sbjct: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT 284
Query: 595 -------------------------------IPQFIGRSYLTYD---NPDILKRVSGSRS 620
I F G Y YD NP + S
Sbjct: 285 AKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSD 339
Query: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM---VNGS 677
+ + FKT ++GL+L G S +D+++L L++GA+ NLGSG + VNG
Sbjct: 340 EITLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
Query: 678 FNDGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGAL 722
FND WH VK R+ + S I+VD TG + L +
Sbjct: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFF 454
Query: 723 YVGGMKEIALHTNRQYMRGLVGCI 746
YVGG A +GC+
Sbjct: 455 YVGGSPSTADLPGSPVSNNFMGCL 478
Score = 53.9 bits (128), Expect = 6e-07
Identities = 54/221 (24%), Positives = 98/221 (44%), Gaps = 29/221 (13%)
Query: 167 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 223
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 282
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
Query: 283 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 327
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
Query: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHC 367
GE G C++GG C+ + D +C C GF+G+ C
Sbjct: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDC 255
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 124 bits (310), Expect = 4e-28
Identities = 139/531 (26%), Positives = 215/531 (40%), Gaps = 82/531 (15%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 172
C +C CVN GG C C G+ E +P S+VTF L+ +
Sbjct: 1407 CANGVCKNGGTCVN-LLIGGFHCVCPPGEYERPYCEVTTRSFPP---QSFVTFRGLRQRF 1462
Query: 173 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSE-- 229
F I+L F + +GLLLY G NE + DF++L I+ +Q F+ G + +
Sbjct: 1463 H-FTISLTFATQERNGLLLYNGRFNE--KHDFIALEIVDEQVQLTFSAGETTTTVAPKVP 1519
Query: 230 TKIKLGGWHTVML--YRDGLNGLLQLNNG------TPVT------------GQSQGQYS- 268
+ + G WH+V + Y G L L +G VT G+ G YS
Sbjct: 1520 SGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSC 1579
Query: 269 -----------KITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWP 317
+ PL LGG P+ NR F GC+++L+V+G+ +DM +
Sbjct: 1580 AAQGTQTGSKKSLDLTGPLLLGGVPNL--PEDFPVHNRQFVGCMRNLSVDGKNVDMAGF- 1636
Query: 318 LGKALSGADVGECSS--GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTI 375
A +G G C++ CD C +GGTC + + Y+C CPL F G++CE A
Sbjct: 1637 --IANNGTREG-CAARRNFCDGRRCQNGGTCVN-RWNMYLCECPLRFGGKNCEQAMPHPQ 1692
Query: 376 PQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGG 435
ES+ S++ + YL M FR D VL+ + G F + +
Sbjct: 1693 LFSGESVVSWSDLNIIISVPWYLGLM-----FRTRKEDSVLMEATSGGPTSF-RLQILNN 1746
Query: 436 HVEFRFDCGSG--TGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQ 493
+++F G V+ S +T G WH L + KN + + +V + G Q
Sbjct: 1747 YLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIE--LKNVKEDSEMKHLVTMTLDYGMDQ 1804
Query: 494 IKCNTDIFIGGVPNYDDV-----KKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE 548
K + + G+ V + V + F G +Q + + +V + +N+
Sbjct: 1805 NKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNV-----ATLNMN 1859
Query: 549 NAA-----------HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 588
NA PC +PC C E Y C C G+ G++C A
Sbjct: 1860 NALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDA 1910
Score = 90.9 bits (224), Expect = 4e-18
Identities = 112/470 (23%), Positives = 195/470 (41%), Gaps = 81/470 (17%)
Query: 329 ECSSGICDEASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAA 387
+ SG C C +GGTC + + C+CP G ++ +CE PQ + R
Sbjct: 1401 DARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRG--- 1457
Query: 388 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGSG 446
L + + + +TF +G+LLY+ K DF+++ + V+ F G
Sbjct: 1458 ----LRQRFHFTI---SLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGET 1510
Query: 447 TGVLRSEDP--LTLGNWHELRVSRTAKNGILQV--------DKQKIV------------- 483
T + + P ++ G WH ++V K I + +K +V
Sbjct: 1511 TTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRF 1570
Query: 484 -----------EGMAEGGFTQIKCNTDIFIGGVPNY-DDVKKNSGVLKPFSGSIQKIILN 531
+G G + + +GGVPN +D ++ + F G ++ + ++
Sbjct: 1571 GKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHN---RQFVGCMRNLSVD 1627
Query: 532 DRTIHVKHDFTSGVNVENAA---HPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 588
+ + + + E A + C C +GG+C R Y C+CPL F G +C+
Sbjct: 1628 GKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCE-- 1685
Query: 589 IIEAIEIPQ-FIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 647
+A+ PQ F G S +++ + +I+ V + + F+T +D +L+ P S
Sbjct: 1686 --QAMPHPQLFSGESVVSWSDLNIIISVPW---YLGLMFRTRKEDSVLMEATSG--GPTS 1738
Query: 648 DFISLGLRDGALVFSYNLG-SGVASIMVNG-SFNDGRWH----RVKAVRDGQSGKITVD- 700
L + + L F + G S V S+M++G DG WH +K V++ K V
Sbjct: 1739 --FRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTM 1796
Query: 701 --DYGARTGKSP--GMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 746
DYG K+ GM+ L + ++ VGG E + RG GC+
Sbjct: 1797 TLDYGMDQNKADIGGMLPGLTVR-SVVVGGASEDKVSVR----RGFRGCM 1841
Score = 67.0 bits (162), Expect = 6e-11
Identities = 77/316 (24%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFF-GHSYVTFEPLKNS 171
CD C CVN W C+C L GG++C + + +PQ F G S V++ L
Sbjct: 1653 CDGRRCQNGGTCVN--RWNMYLCECPLRFGGKNCEQ--AMPHPQLFSGESVVSWSDLNII 1708
Query: 172 YQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG--VAIIVS 228
+ + L FR ED +L+ E G L I+ LQF + G ++++S
Sbjct: 1709 ISVPWYLGLMFRTRKEDSVLM---EATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLS 1765
Query: 229 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVT---GQSQ------GQYSKITFRTPLYLG 279
++ G WH +++ + ++ + +T G Q G +T R+ + +G
Sbjct: 1766 GLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRS-VVVG 1824
Query: 280 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS-----GADVGE-CSSG 333
GA VR RGF+GC+Q + + G ++ + AL G DV + C+S
Sbjct: 1825 GASEDKVSVR-----RGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSS 1879
Query: 334 IC----------DEASCI--------------HGGTCTAIKA--------DSYICLCPLG 361
C ++ SC+ H C + A Y+C C
Sbjct: 1880 PCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPS 1939
Query: 362 FKGRHCEDAFTLTIPQ 377
G +CE+ L P+
Sbjct: 1940 HYGPYCENKLDLPCPR 1955
Score = 62.8 bits (151), Expect = 1e-09
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 95/292 (32%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIE--------------IPQFI 599
C PC G CR R+ GY C+C F G HC+ ++A + I
Sbjct: 1367 CYSDPCGANGRCRSREGGYTCECFEDFTGEHCE---VDARSGRCANGVCKNGGTCVNLLI 1423
Query: 600 GRSYLT-----YDNP--DILKRVSGSRSNVFMR-------------FKTTAKDGLLLWRG 639
G + Y+ P ++ R +S V R F T ++GLLL+ G
Sbjct: 1424 GGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNG 1483
Query: 640 DSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM--VNGSFNDGRWHRVK---------- 687
DFI+L + D + +++ G ++ V +DGRWH V+
Sbjct: 1484 R--FNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIG 1541
Query: 688 --AVRDGQSGK----ITVDD--------YG--------ARTGKSPGMMRQLNINGALYVG 725
+ G SG+ +TVDD +G A G G + L++ G L +G
Sbjct: 1542 HLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLG 1601
Query: 726 GM----KEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCG 773
G+ ++ +H NRQ+ VGC+ + +VDGKN++ G
Sbjct: 1602 GVPNLPEDFPVH-NRQF----VGCMRNL-------------SVDGKNVDMAG 1635
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 114 bits (286), Expect = 3e-25
Identities = 141/629 (22%), Positives = 254/629 (40%), Gaps = 118/629 (18%)
Query: 135 CQCT-LGKGGESCSEDIVIQYPQ-------------------FFGHSYVTFEPLKNSYQA 174
C C+ G GG+ CSE+ ++P F G+ + ++ N Q+
Sbjct: 229 CDCSHTGFGGKFCSEE---EHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQS 285
Query: 175 F--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET-- 230
+ITL FR +GL+L+ G++ D+++L++ ++ N G+G + E
Sbjct: 286 STDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
Query: 231 -KIKLGGWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGA 281
K WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+
Sbjct: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGS 401
Query: 282 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCI 341
P+ L + +N F GC++ + + L K
Sbjct: 402 PNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELSRLAK--------------------- 439
Query: 342 HGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSF 400
G ++ D L F+ CED L F ES ++ A P W + +S
Sbjct: 440 EGDPKMKLQGD-------LSFR---CEDVAALDPVTF-ESPEAFVALPRWSAKRTGSIS- 487
Query: 401 MEFEITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTG 448
+ FR +G+LL+S GS D+ ++ L GH+ D GSG
Sbjct: 488 ----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGI 543
Query: 449 VLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 507
LR S + G W + R + G + V+ + +A G + +++++GG+P
Sbjct: 544 KLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE 602
Query: 508 YDDVKK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHP 553
V + + + G ++ + ++ R+ ++ + V V
Sbjct: 603 GGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQ 662
Query: 554 CVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 612
C APC +GG CR + CDC GF G C++ + + G Y+ P+ +
Sbjct: 663 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAM 718
Query: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
+ +V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 719 HTEA---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETL 772
Query: 673 MVNGSFNDGRWHRVKAVRDGQSGKITVDD 701
ND WH V+ VR G+S +++VD+
Sbjct: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
Score = 110 bits (274), Expect = 6e-24
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 460
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 461 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 519
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 520 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 571
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 572 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 612
CDC GF G C + E E + F G + YD NP
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
Query: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
Query: 673 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 721
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
Query: 722 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 766
Y+GG A +GC+ + D+ + L A +G
Sbjct: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Score = 108 bits (269), Expect = 2e-23
Identities = 153/651 (23%), Positives = 259/651 (39%), Gaps = 84/651 (12%)
Query: 95 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 151
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 644 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 700
Query: 152 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIR 210
+ + G Y+ P +A ++L F ++ GL++ E D + L +
Sbjct: 701 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESA--DTLRLELDG 756
Query: 211 RSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKI 270
++ N G G + + K+ WHTV + R G + L ++N T V GQ G + ++
Sbjct: 757 GQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQMAGAHMRL 815
Query: 271 TFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC 330
F G + + +N F G + L NG+ P D+ C
Sbjct: 816 EFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCKDGDITYC 864
Query: 331 SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW 390
E + G AI AD P+ FK R A +L++YA+
Sbjct: 865 ------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQAYAS--- 899
Query: 391 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 450
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G ++
Sbjct: 900 ----------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLM 948
Query: 451 R--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 507
+ S+ P+ WH + VSR N L++D + + + G + +++IGG+
Sbjct: 949 KGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSK 1006
Query: 508 --YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCA 560
+ ++ K F G + + LN R + D + + + C CA
Sbjct: 1007 NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1066
Query: 561 HGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSR 619
+ G C + +G+ CDC + + G C I G + +TY P R S
Sbjct: 1067 NQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRM 1122
Query: 620 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSF 678
+ + F T + +L+ R DS D++ L + G + +N+G+ +I N
Sbjct: 1123 DRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
Query: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 726
+DG++H V+ R G + + VD + G RQL N A+ +GG
Sbjct: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
Score = 102 bits (255), Expect = 1e-21
Identities = 143/603 (23%), Positives = 249/603 (41%), Gaps = 101/603 (16%)
Query: 176 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 234
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
Query: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
Query: 295 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 351
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
Query: 352 DSYICLCP-LGFKGRHCEDA---------FTLTIPQFRESLRSYAATPW--------PLE 393
C C GF G+ C + TL E + ++ + P++
Sbjct: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQ 284
Query: 394 PQHYLSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRS 452
S E + FR +G++L+ TG S D+++++L G V + GSG
Sbjct: 285 S----STDEITLAFRTLQRNGLMLH---TGKSADYVNLSLKSGAVWLVINLGSGAFEALV 337
Query: 453 EDPLTLGN---WHELRVSRTAKN--GI------LQVDKQKIVEGMAEGGFTQIKCNTDIF 501
E N WH++RV+R + GI + VD G + +T + + +
Sbjct: 338 EPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY 397
Query: 502 IGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAH 561
IGG PN D+ S V F G ++ + ++ +DF ++
Sbjct: 398 IGGSPNTADL-PGSPVSNNFMGCLKDV------VYKNNDFKLELS--------------- 435
Query: 562 GGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAIEIPQFIGRSYLTYDNPD---ILKRVSG 617
R KEG D + +G L + + A++ +T+++P+ L R S
Sbjct: 436 ----RLAKEG---DPKMKLQGDLSFRCEDVAALD--------PVTFESPEAFVALPRWSA 480
Query: 618 SRS-NVFMRFKTTAKDGLLLW---------RGDSPMRPNSDFISLGLRDGALVFSYNLGS 667
R+ ++ + F+TT +GLLL+ G +D+ ++ L DG L ++GS
Sbjct: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
Query: 668 GVASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 726
G + + NDG W V RDG+ G I+V+ + + G L++ LY+GG
Sbjct: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGG 599
Query: 727 MKE 729
+ E
Sbjct: 600 LPE 602
Score = 94.7 bits (234), Expect = 3e-19
Identities = 99/384 (25%), Positives = 165/384 (42%), Gaps = 37/384 (9%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 887 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 942
Query: 221 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 943 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1001
Query: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 1002 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1058
Query: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 1059 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1114
Query: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 451
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 1115 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1172
Query: 452 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPN 507
++P + G +H +R +R+ N LQVD + E G T I IGG
Sbjct: 1173 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG--- 1229
Query: 508 YDDVKKNSGVLKPFSGSIQKIILN 531
++ G +PF G + + N
Sbjct: 1230 -----RDQG--RPFQGQVSGLYYN 1246
Score = 92.8 bits (229), Expect = 1e-18
Identities = 97/365 (26%), Positives = 151/365 (41%), Gaps = 44/365 (12%)
Query: 163 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 204
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 464 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 523
Query: 205 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 262
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 524 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 581
Query: 263 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 315
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 582 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRG 641
Query: 316 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 370
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 642 --LAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCERE 698
Query: 371 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 430
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 699 --ATVLSYDGSMYMKIMLPNAMHTEAE----DVSLRFMSQRAYGLMMATTSRESADTLRL 752
Query: 431 NLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGG 490
L GG ++ + G G L + L WH +RV R K+ L VD VEG G
Sbjct: 753 ELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-NVTVEGQMAGA 811
Query: 491 FTQIK 495
+++
Sbjct: 812 HMRLE 816
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 678
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
Query: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
Score = 46.2 bits (108), Expect = 1e-04
Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 20/205 (9%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 170
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 1060 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
Query: 171 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 228
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 1118 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1176
Query: 229 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ--SQGQYSKITFRTPLYLGGAPSAYW 286
+ G +H V R G N LQ+++ PV + + Q + + + +GG
Sbjct: 1177 NAIVSDGKYHVVRFTRSGGNATLQVDS-WPVNERYPAGRQLTIFNSQAAIKIGGRDQ--- 1232
Query: 287 LVRATGTNRGFQGCVQSLAVNGRRI 311
R FQG V L NG ++
Sbjct: 1233 -------GRPFQGQVSGLYYNGLKV 1250
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 113 bits (282), Expect = 8e-25
Identities = 155/656 (23%), Positives = 258/656 (39%), Gaps = 108/656 (16%)
Query: 106 SRLFDMPCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVT 164
SR+ CD C ++ C + W C CT G G +C + I + G Y+
Sbjct: 267 SRMSAKQCDSYPCKNNAVCKDG--WNRFICDCTGTGYWGRTCEREASIL--SYDGSMYMK 322
Query: 165 F-EPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDFMSLAIIRRSLQFR 216
P+ +A ++ F ++ GLL+ + G + L + ++
Sbjct: 323 IIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRIN 382
Query: 217 FNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-- 274
N G + + K+ WHTV + R G + L +++ G G ++++ F
Sbjct: 383 CNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDV-AEGTMVGDHTRLEFHNIE 441
Query: 275 ------PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR-IDMRPWPLGKALSGADV 327
Y+ PS+ F G +QSL NG ID+
Sbjct: 442 TGIMTEKRYISVVPSS------------FIGHLQSLMFNGLLYIDL-------------- 475
Query: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 387
C +G D I AD P+ FK + S S A
Sbjct: 476 --CKNGDIDYCELKARFGLRNIIAD------PVTFKTK--------------SSYLSLAT 513
Query: 388 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT 447
Q Y S M F+ S DG +L++ G+ DF+++ L G++ + FD G+G
Sbjct: 514 L------QAYTS-MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGP 565
Query: 448 GVLR--SEDPLTLGNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG 504
V++ S+ PL WH + ++R N L+VD + + + + G + D+++ G
Sbjct: 566 NVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAG 623
Query: 505 VPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRA 557
+ Y ++ K F G + + LN R + +D SG E + C
Sbjct: 624 LAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQED 683
Query: 558 PCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKR 614
CA+ G C + EG+ CDC + + G C I G+S + Y P R
Sbjct: 684 SCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDR 737
Query: 615 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV 674
S + + F TT KDG+L+ +P DF+ L + G + +N+G+ SI
Sbjct: 738 PSTRSDRLAVGFSTTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKE 795
Query: 675 NGS-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 726
+ NDG++H V+ R+G + + VD++ G RQL N + +GG
Sbjct: 796 ERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
Score = 87.0 bits (214), Expect = 6e-17
Identities = 102/467 (21%), Positives = 189/467 (40%), Gaps = 96/467 (20%)
Query: 277 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 336
Y+GG+PS L + +N F GC++ + I + L + I D
Sbjct: 9 YVGGSPSTADLPGSPVSNN-FMGCLKEVVYKNNDIRLELSRLAR-------------IAD 54
Query: 337 EASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQ 395
I+G K ++ L P+ F E+ +Y + P W +
Sbjct: 55 TKMKIYGEV--VFKCENVATLDPINF-----------------ETPEAYISLPKWNTKRM 95
Query: 396 HYLSFMEFEITFRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDC 443
+SF FR +G++L+++ D S+ DF ++ L G++ D
Sbjct: 96 GSISF-----DFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDM 150
Query: 444 GSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFI 502
GSGT V ++ G W+ + + R ++G + V+ ++ A G + D+++
Sbjct: 151 GSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYL 209
Query: 503 GGVPNYDDVKKNSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVEN 549
GG+P + +G++ P + G I+ + ++ R+ +++ + + V++
Sbjct: 210 GGLP-----ENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKS 264
Query: 550 A-----AHPCVRAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSY 603
+ A C PC + C+ + CDC G+ G C++ I + G Y
Sbjct: 265 SCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMY 320
Query: 604 LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSY 663
+ P ++ + +V RF + GLL+ + R ++D + L L G +
Sbjct: 321 MKIIMPMVMHTEA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMV 374
Query: 664 NL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 701
NL G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 375 NLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
Score = 85.9 bits (211), Expect = 1e-16
Identities = 96/396 (24%), Positives = 168/396 (42%), Gaps = 46/396 (11%)
Query: 167 PLKNSYQAFQITLEFRAEAEDGLLLY----------CGENEHGRGDFMSLAIIRRSLQFR 216
P N+ + I+ +FR +GL+L+ ++ + DF ++ ++ +L
Sbjct: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
Query: 217 FNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQSQGQYSKITFRT 274
+ G+G + + ++ K G W+ V + RDG +G + +N+ TP T + G+ +
Sbjct: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT--ASGESEILDLEG 205
Query: 275 PLYLGGAP-SAYWLVRATG-----TNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG--AD 326
+YLGG P + L+ T N G+ GC++ L ++GR ++R + +G +
Sbjct: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSS 265
Query: 327 VGECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCEDAFTLTIPQFRESLRSY 385
S+ CD C + C + +IC C G+ GR CE +I + S+
Sbjct: 266 CSRMSAKQCDSYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCER--EASILSYDGSMYMK 322
Query: 386 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE------- 438
P + + + F G+L+ + S D L + L GG V+
Sbjct: 323 IIMPMVM----HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDC 378
Query: 439 FRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKC 496
R +C S G L + L WH +RV R K+ L VD + EG G T+++
Sbjct: 379 IRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD-DDVAEGTMVGDHTRLEF 437
Query: 497 -NTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 531
N + I Y V +S F G +Q ++ N
Sbjct: 438 HNIETGIMTEKRYISVVPSS-----FIGHLQSLMFN 468
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 110 bits (276), Expect = 4e-24
Identities = 128/530 (24%), Positives = 210/530 (39%), Gaps = 100/530 (18%)
Query: 135 CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPL--KNSYQAFQITLEFRAEAEDGLLLY 192
C C G G+ C + F SY+ F L N+Y I ++F LLLY
Sbjct: 3962 CHCPFGVFGKHCE----LNSYGFEELSYMEFPSLDPNNNY----IYVKFATIKSHALLLY 4013
Query: 193 CGENEHG-RGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLL 251
+N+ G R +F++L I L+F +N G+G + + K+ G +HTV+ R G+ L
Sbjct: 4014 NYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARRAGMAASL 4073
Query: 252 QLNNGTPVTGQSQGQYSKITFR---------TPLYLGGAPSAYWLVRATG--TNRGFQGC 300
+++ + S + + +GG S +++ G + F GC
Sbjct: 4074 TVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGC 4133
Query: 301 VQSLAVNGRRIDMRPWPLGKALSGADVGECS--SGICDEASCIHGGTCTAIKADSYICLC 358
+ AVNGR ++ P + + +C G C + C HGGTC + C C
Sbjct: 4134 IMEFAVNGRPLE----PSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQ-CHC 4188
Query: 359 PLGFKGRHCEDAFT----------------LTIPQFRESLRSYAATPWPLEPQHYLSFME 402
G G++CE + T ++ + RE L + LEP
Sbjct: 4189 KEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEP---FGVNS 4245
Query: 403 FEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRS--EDPLTLGN 460
E+ FR S +GVL++ + S ++ ++ + G V F D G V R+ E + G+
Sbjct: 4246 LEVKFRTRSENGVLIHIQE--SSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGH 4303
Query: 461 WHELRVSRTAKNGILQVDK---QKIVEGMAEGGFTQIKCNTDIFIGGVP----------- 506
WH + + +L VD+ + I+ + G + I +GG+P
Sbjct: 4304 WHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDV---LTISLGGIPPNQAHRDAQTA 4360
Query: 507 NYDDVKKN---SGVLKPFSG--SIQKIILNDRTIHVKHDFTSGVNVENAAHP-------- 553
+D + G PFSG S+ I D ++ + G N+ A++P
Sbjct: 4361 GFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIG---CRGPNI-CASNPCWGDLLCI 4416
Query: 554 -------------CVRAPCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAI 589
C PC +GGSC P G+ C CP G C+ +
Sbjct: 4417 NQWYAYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVV 4466
Score = 109 bits (272), Expect = 1e-23
Identities = 116/492 (23%), Positives = 207/492 (42%), Gaps = 62/492 (12%)
Query: 295 RGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGE-CSSGI--CDEASCIHGGTCTAIKA 351
R C+QS NG P G+ C S + C+ C +GG+C +
Sbjct: 3899 RDINECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQS-GV 3957
Query: 352 DSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDS 411
DSY C CP G G+HCE L F E SY P L+P + +++F
Sbjct: 3958 DSYYCHCPFGVFGKHCE----LNSYGFEEL--SYMEFP-SLDPNNNYIYVKFATI----K 4006
Query: 412 GDGVLLYSYD--TGSK-DFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSR 468
+LLY+YD TG + +FL++ +A + F ++ GSGT L + ++ G++H + R
Sbjct: 4007 SHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTMKKVSDGHFHTVIARR 4066
Query: 469 TAKNGILQVDKQKIVEGMAEGGFTQIKCNTD---------IFIGGVPNYDDVKKNSGVLK 519
L VD + + + + D + +GG+ + + + + G ++
Sbjct: 4067 AGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVE 4126
Query: 520 P--FSGSIQKIILNDRTIHVKHDFTSGVNVENAAH---PCVRAPCAHGGSCRPRKEGYDC 574
F G I + +N R + + ++ C R+PC HGG+C C
Sbjct: 4127 SHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQC 4186
Query: 575 DCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR-------VSGSRSNVF---- 623
C G G +C+K++ + G+ L Y KR + G+ F
Sbjct: 4187 HCKEGLTGKYCEKSVTPDTAL-SLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNS 4245
Query: 624 --MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFN 679
++F+T +++G+L+ ++ +S++ ++ +++G + F+ + G V +
Sbjct: 4246 LEVKFRTRSENGVLI-----HIQESSNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVA 4300
Query: 680 DGRWHRVKAVRDGQSGKITVDDYGARTGKSP----GMMRQLNINGALYVGGMKEIALHTN 735
DG WH ++G + ++VD R P G + L I+ +GG+ H +
Sbjct: 4301 DGHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLTIS----LGGIPPNQAHRD 4356
Query: 736 RQYMRGLVGCIS 747
Q G GCI+
Sbjct: 4357 AQ-TAGFDGCIA 4367
Score = 89.0 bits (219), Expect = 2e-17
Identities = 72/277 (25%), Positives = 114/277 (41%), Gaps = 41/277 (14%)
Query: 490 GFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVEN 549
GFT C DI KN + + F GS + T G E+
Sbjct: 3891 GFTGRACERDIN----ECLQSPCKNGAICQNFPGSFNCVCKTGYT---------GKMCES 3937
Query: 550 AAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 609
+ + C PC +GGSC+ + Y C CP G G HC+ + F SY+ + +
Sbjct: 3938 SVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE------LNSYGFEELSYMEFPSL 3991
Query: 610 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 669
D + + ++++F T LLL+ D+ ++F++L + + L FSYNLGSG
Sbjct: 3992 D------PNNNYIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGT 4045
Query: 670 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNI----------- 718
+ +DG +H V A R G + +TVD + PG N+
Sbjct: 4046 YKLTTMKKVSDGHFHTVIARRAGMAASLTVD--SCSENQEPGYCTVSNVAVSDDWTLDVQ 4103
Query: 719 NGALYVGGMKEIALHTNRQ---YMRGLVGCISHFTLS 752
+ VGG++ + R+ VGCI F ++
Sbjct: 4104 PNRVTVGGIRSLEPILQRRGHVESHDFVGCIMEFAVN 4140
Score = 50.1 bits (118), Expect = 8e-06
Identities = 63/330 (19%), Positives = 113/330 (34%), Gaps = 66/330 (20%)
Query: 93 PIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIV- 151
P Q G+ + C + C C++ ++W +C C G G+ C + +
Sbjct: 4146 PSQALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSW--QQCHCKEGLTGKYCEKSVTP 4203
Query: 152 -------------IQYPQFFGHSYVTFEPLKNS----YQAFQITLEFRAEAEDGLLLYCG 194
Q Y+ + L+ + + + ++FR +E+G+L++
Sbjct: 4204 DTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQ 4263
Query: 195 ENEHGRGDFMSLAIIRRSLQFRFNCGTG--VAIIVSETKIKLGGWHTVMLYRDGLNGLLQ 252
E+ ++ ++ I + F + G V + E + G WHT ++ ++G +L
Sbjct: 4264 ES----SNYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLS 4319
Query: 253 L----NNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNG 308
+ N Q G +T + LGG P GF GC+ S+ G
Sbjct: 4320 VDRIYNRDIIHPTQDFGGLDVLT----ISLGGIPPNQ--AHRDAQTAGFDGCIASMWYGG 4373
Query: 309 RRIDMRPWPLGKALSGADVGE---------CSS---------------------GICDEA 338
+ ++S D C+S G C
Sbjct: 4374 ESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPPGDCASH 4433
Query: 339 SCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
C +GG+C + C CP GR CE
Sbjct: 4434 PCQNGGSCEPGLHSGFTCSCPDSHTGRTCE 4463
Score = 45.1 bits (105), Expect = 3e-04
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
C+ +PC GG+C G+ C CP GF G C++ I E ++ P
Sbjct: 3866 CLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSP 3908
Score = 35.8 bits (81), Expect = 0.16
Identities = 45/174 (25%), Positives = 66/174 (37%), Gaps = 46/174 (26%)
Query: 448 GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP- 506
GV +D LT H LR++ + G+ G A ++ + N F+
Sbjct: 3718 GVPTVKDFLTNHYLHFLRIASSQLTGL----------GTAVQLYSAYEENNRTFLLAAVK 3767
Query: 507 -NYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHP-CVRAPCAHGGS 564
N++ SGV F SI++I+L SGV VE+ H CV PC +GGS
Sbjct: 3768 RNHNQYVNPSGVATFFE-SIKEILLRQ----------SGVKVESVDHDSCVHGPCQNGGS 3816
Query: 565 CRPR----------------------KEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
C R + + C C G+ G C+ I E + P
Sbjct: 3817 CLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDECLPSP 3870
Score = 33.9 bits (76), Expect = 0.59
Identities = 21/53 (39%), Positives = 24/53 (45%), Gaps = 3/53 (5%)
Query: 318 LGKALSGADVGECSSGI--CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
L K L G C I C + C GGTC + + C CP GF GR CE
Sbjct: 3847 LCKCLPGYAGSWCEIDIDECLPSPCHSGGTCHNL-VGGFSCSCPDGFTGRACE 3898
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 105 bits (263), Expect = 1e-22
Identities = 131/610 (21%), Positives = 244/610 (40%), Gaps = 119/610 (19%)
Query: 176 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLG 235
QI + F + +GLLLY G +G DF+S+ + R ++ + G+G ++++ + G
Sbjct: 2328 QIIMLFNTFSPNGLLLYLGS--YGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNG 2385
Query: 236 GWHTVMLYRDGLNGLLQL------NNGTPVTGQSQGQYSKITF--RTPLYLGGAPSAYWL 287
W+ + R+ G+L + +N G++ G S + + P+Y+GG P + +
Sbjct: 2386 TWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSR-V 2444
Query: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
VR T + F GC+++L ++ D+ + + G
Sbjct: 2445 VRRGVTTKSFVGCIKNLEISRSTFDL--------------------LRNSYGVRKGCLLE 2484
Query: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITF 407
I++ S++ KG + E L P+ E+ +TF
Sbjct: 2485 PIRSVSFL-------KGGYIE-----------------------LPPKSLSPESEWLVTF 2514
Query: 408 RPDSGDGVLLYSYD-----TGSKD-----FLSINLAGGHVEFRFDCGSGTGVLRS----- 452
+ G++L + G ++ F S+ L GG++E + G GTG+ ++
Sbjct: 2515 ATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAP 2574
Query: 453 EDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN--TDIFIGGVPNYDD 510
+ G H + + R + +Q+D+ VE M G + + +++++GG+P +
Sbjct: 2575 TGTCSDGQAHSISLVRNRRIITVQLDENNPVE-MKLGTLVESRTINVSNLYVGGIPEGEG 2633
Query: 511 VKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENA-------AHPCVRAPCAHGG 563
+ + + F G I+ +I N + DF S V E + AP A
Sbjct: 2634 TSLLT-MRRSFHGCIKNLIFNLELL----DFNSAVGHEQVDLDTCWLSERPKLAPDAEDS 2688
Query: 564 SCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSY-----LTYDNPDILKRVSGS 618
P + C + A +E + G + L ++ + K++S
Sbjct: 2689 KLLPEPRAFPEQCVVD--------AALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLS-- 2738
Query: 619 RSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSF 678
V + +T A GL+ + + +D+ L L G L F ++LG G +
Sbjct: 2739 ---VELSIRTFASSGLIYYMAH---QNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALL 2792
Query: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQY 738
+DG+WH VK + G ITVD + G L++ G Y+GG+ QY
Sbjct: 2793 SDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPS-------QY 2845
Query: 739 MRGLVGCISH 748
+G I+H
Sbjct: 2846 QARKIGNITH 2855
Score = 85.1 bits (209), Expect = 2e-16
Identities = 88/393 (22%), Positives = 160/393 (40%), Gaps = 71/393 (18%)
Query: 379 RESLRSYAATPWPLEPQ-HYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHV 437
R+ +R+Y +PQ ++ + + D +L Y + + DFL++ + G V
Sbjct: 2124 RDCIRAY-------QPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRV 2176
Query: 438 EFRFDCGSGTGVLRSED-PLTLGNWHELRVSRTAKNGILQVDKQ--------KIVEGMAE 488
F +D GSG+ L D P+ WH + V+R G L V + K +
Sbjct: 2177 AFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGT 2236
Query: 489 GGFTQIKCNTDIFIGGVPNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNV 547
+ +T +F+GG+ +KK+ V + F G + + LN ++I + + +
Sbjct: 2237 ANVLDVNNSTLMFVGGLGG--QIKKSPAVKVTHFKGCLGEAFLNGKSIGL----WNYIER 2290
Query: 548 ENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYD 607
E C GS + + D G Y +
Sbjct: 2291 EGKCRGCF-------GSSQNEDPSFHFD------------------------GSGYSVVE 2319
Query: 608 NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS 667
K + + + + M F T + +GLLL+ G + DF+S+ L G + +LGS
Sbjct: 2320 -----KSLPATVTQIIMLFNTFSPNGLLLYLGSYGTK---DFLSIELFRGRVKVMTDLGS 2371
Query: 668 GVASIMVNGSFNDGRWHRVKAVRDGQSGKITV-DDYG-----ARTGKSPGMMRQLN--IN 719
G +++ + +N+G W+++ R+ + G + V D Y + G++PG LN
Sbjct: 2372 GPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDK 2431
Query: 720 GALYVGGMKEIALHTNRQYMRGLVGCISHFTLS 752
+YVGG+ + + VGCI + +S
Sbjct: 2432 DPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEIS 2464
Score = 80.9 bits (198), Expect = 4e-15
Identities = 113/546 (20%), Positives = 196/546 (35%), Gaps = 73/546 (13%)
Query: 194 GENEHGRGDFMSLAIIRRSLQFRFNCGTGV----AIIVSETKIKLGGW-HTVMLYRDGLN 248
G+ E F S+ +I +++ N G G A++ + T G H++ L R+
Sbjct: 2535 GDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRI 2594
Query: 249 GLLQLNNGTPVTGQSQGQYSKITFRTP-LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVN 307
+QL+ PV + T LY+GG P T R F GC+++L N
Sbjct: 2595 ITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLT-MRRSFHGCIKNLIFN 2653
Query: 308 GRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHC 367
+D A+ V + + + DS + P F +
Sbjct: 2654 LELLDFN-----SAVGHEQVDLDTCWLSERPKLAPDAE------DSKLLPEPRAFPEQCV 2702
Query: 368 EDAFTLTIP---QFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGS 424
DA +P QF + S+ P+ + E++ R + G++ Y
Sbjct: 2703 VDAALEYVPGAHQFGLTQNSHFILPF--NQSAVRKKLSVELSIRTFASSGLIYYMAHQNQ 2760
Query: 425 KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVE 484
D+ + L GG + F FD G G + L+ G WH ++ + G + VD ++
Sbjct: 2761 ADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPM 2820
Query: 485 GMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSG 544
G T + ++GG+P+ +K + I + +N + + K S
Sbjct: 2821 VTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQLD-KDSPVSA 2879
Query: 545 VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 604
V N + + GS GY L EG Q +
Sbjct: 2880 FTV-NRCYAVAQEGTYFDGS------GY---AALVKEGYKVQSDV--------------- 2914
Query: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
N+ + F+T++++G+LL + + D I L L DG ++F N
Sbjct: 2915 ----------------NITLEFRTSSQNGVLLGISTAKV----DAIGLELVDGKVLFHVN 2954
Query: 665 LGSGVASIMVNGS----FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNING 720
G+G + DG+WH ++A + + VD ++ N
Sbjct: 2955 NGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNN 3014
Query: 721 ALYVGG 726
+YVGG
Sbjct: 3015 PIYVGG 3020
Score = 77.8 bits (190), Expect = 4e-14
Identities = 139/641 (21%), Positives = 238/641 (37%), Gaps = 130/641 (20%)
Query: 165 FEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG-V 223
++P +S +TL + + D LL Y G + DF+++ + R + F ++ G+G
Sbjct: 2130 YQPQISSTNYNTLTLNVKTQEPDNLLFYLGSST--ASDFLAVEMRRGRVAFLWDLGSGST 2187
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPV-TGQSQGQYS--KITFRTP 275
+ + I WH++ + R G G L + N +P T +S G + + T
Sbjct: 2188 RLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTL 2247
Query: 276 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGIC 335
+++GG A F+GC+ +NG+ I + W + I
Sbjct: 2248 MFVGGLGGQIKKSPAVKVTH-FKGCLGEAFLNGKSIGL--W---------------NYIE 2289
Query: 336 DEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQ 395
E C R C + P F Y+ L
Sbjct: 2290 REGKC------------------------RGCFGSSQNEDPSFHFDGSGYSVVEKSLPAT 2325
Query: 396 HYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP 455
M F TF P +G+LLY G+KDFLSI L G V+ D GSG L ++
Sbjct: 2326 VTQIIMLFN-TFSP---NGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRR 2381
Query: 456 LTLGNWHELRVSRTAKNGILQV------DKQKIVEGMAEGGFTQI-KCNTD-IFIGGVPN 507
G W+++ R K G+L V ++ +G G + + + + D I++GG+P
Sbjct: 2382 YNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPR 2441
Query: 508 YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRP 567
V + K F G I+ + ++ T + + VR C
Sbjct: 2442 -SRVVRRGVTTKSFVGCIKNLEISRSTFDLLRNSYG-----------VRKGC-------- 2481
Query: 568 RKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFK 627
++E I F+ Y+ ++ + S + F
Sbjct: 2482 ---------------------LLEPIRSVSFLKGGYI-----ELPPKSLSPESEWLVTFA 2515
Query: 628 TTAKDGLLL--WRGDSPMRPNSD-----FISLGLRDGALVFSYNLGSGVASIMV-----N 675
TT G++L GD R + + F S+ L G + N G G
Sbjct: 2516 TTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPT 2575
Query: 676 GSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNIN-GALYVGGMKEIALHT 734
G+ +DG+ H + VR+ + + +D+ K ++ IN LYVGG+ E +
Sbjct: 2576 GTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTS 2635
Query: 735 NRQYMRGLVGCISHFTLS---TDYHISLVEDAVDGKNINTC 772
R GCI + + D++ ++ + VD ++TC
Sbjct: 2636 LLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVD---LDTC 2673
Score = 64.7 bits (156), Expect = 3e-10
Identities = 71/335 (21%), Positives = 114/335 (34%), Gaps = 56/335 (16%)
Query: 177 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 236
+ L R A GL+ Y + D+ L + L F F+ G G + + G
Sbjct: 2739 VELSIRTFASSGLIYYMAHQN--QADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGK 2796
Query: 237 WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRG 296
WHTV G + ++ G + + YLGG PS Y +
Sbjct: 2797 WHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHS 2856
Query: 297 FQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYIC 356
C+ + VN +++D +S V C + + E + G Y
Sbjct: 2857 IPACIGDVTVNSKQLDK-----DSPVSAFTVNRCYA-VAQEGTYFDG--------SGYAA 2902
Query: 357 LCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVL 416
L G+K + S + + FR S +GVL
Sbjct: 2903 LVKEGYKVQ---------------------------------SDVNITLEFRTSSQNGVL 2929
Query: 417 LYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----GNWHELRVSRTAK 471
L T D + + L G V F + G+G + + +P T G WH L+ +++
Sbjct: 2930 L-GISTAKVDAIGLELVDGKVLFHVNNGAGR-ITAAYEPKTATVLCDGKWHTLQANKSKH 2987
Query: 472 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP 506
L VD + T + N I++GG P
Sbjct: 2988 RITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Score = 45.1 bits (105), Expect = 3e-04
Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 13/157 (8%)
Query: 157 FFGHSYVTFEPLKNSYQA---FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSL 213
F G Y +K Y+ ITLEFR +++G+LL + D + L ++ +
Sbjct: 2895 FDGSGYAAL--VKEGYKVQSDVNITLEFRTSSQNGVLLGIST---AKVDAIGLELVDGKV 2949
Query: 214 QFRFNCGTGVAIIVSETKIKL----GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSK 269
F N G G E K G WHT+ + L ++ Q +
Sbjct: 2950 LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTS 3009
Query: 270 ITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAV 306
+ P+Y+GG P+ + + F+GC++ LA+
Sbjct: 3010 VDTNNPIYVGGYPAGV-KQKCLRSQTSFRGCLRKLAL 3045
Score = 32.3 bits (72), Expect = 1.7
Identities = 29/107 (27%), Positives = 37/107 (34%), Gaps = 28/107 (26%)
Query: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 387
G C C+ +HG C C+C LG G C++
Sbjct: 1504 GSCQKCDCNPHGSVHGD-CDRTSGQ---CVCRLGASGLRCDEC----------------- 1542
Query: 388 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAG 434
EP+H L ME + D GVLL D LS+NL G
Sbjct: 1543 -----EPRHIL--METDCVSCDDECVGVLLNDLDEIGDAVLSLNLTG 1582
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 101 bits (251), Expect = 3e-21
Identities = 129/533 (24%), Positives = 199/533 (37%), Gaps = 80/533 (15%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 172
C +C C D GG RCQC G E ++ + F S+V F L+ +
Sbjct: 1479 CVPGVCRNGGTCT-DAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSFVMFRGLRQRF 1535
Query: 173 QAFQITLEFRAEAEDGLLLYCGE-NEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 231
++L F + GLL Y G NE + DF++L ++ ++ ++ G ++
Sbjct: 1536 H-LTLSLSFATVQQSGLLFYNGRLNE--KHDFLALELVAGQVRLTYSTGESNTVVSPTVP 1592
Query: 232 IKL--GGWHTVMLY------RDGLNGL---------------------LQL-----NNGT 257
L G WHTV L D L G LQ N
Sbjct: 1593 GGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSC 1652
Query: 258 PVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWP 317
G + PL LGG P+ +++ F GC++ L ++GRR+DM +
Sbjct: 1653 AAAGVQTSSKKSLDLTGPLLLGGVPNLP--ENFPVSHKDFIGCMRDLHIDGRRVDMAAFV 1710
Query: 318 LGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 376
A +G G + CD C + G C+ + S+ C CP+GF G+ C+ T+ P
Sbjct: 1711 ---ANNGTMAGCQAKLHFCDSGPCKNSGFCSE-RWGSFSCDCPVGFGGKDCQ--LTMAHP 1764
Query: 377 QFRESLRSYAATPWPLEPQHYLSFMEF-EITFRPDSGDGVLLYSYDTGSKDFLSINLAGG 435
R W +S + + FR + GVL+ G L L G
Sbjct: 1765 HH---FRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLM-QVQAGPHSTLLCQLDRG 1820
Query: 436 HVEFRFDCGSGTGVLRSEDPLTL--GNWHELRVSRTAKNG--------ILQVDKQKIVEG 485
+ GSG D +T+ G WH+LR+ + G ++ +D +
Sbjct: 1821 LLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDT 1880
Query: 486 MAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT------IHVKH 539
MA G Q + +GG+P + G++ G IQ + L + H
Sbjct: 1881 MAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLV----GCIQGVWLGSTPSGSPALLPPSH 1936
Query: 540 DFTS--GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAII 590
+ G V NA C PC CR + + C C G+ G C A +
Sbjct: 1937 RVNAEPGCVVTNA---CASGPCPPHADCRDLWQTFSCTCQPGYYGPGCVDACL 1986
Score = 87.8 bits (216), Expect = 3e-17
Identities = 115/469 (24%), Positives = 183/469 (39%), Gaps = 76/469 (16%)
Query: 329 ECSSGICDEASCIHGGTCTAIKADSYICLCPLG--FKGRHCEDAFTLTIPQFRESLRSYA 386
+ +G C C +GGTCT + C CP G F+G CE A P R
Sbjct: 1473 DTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRG-- 1530
Query: 387 ATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSK-DFLSINLAGGHVEFRFDCGS 445
L + +L+ ++F G+L Y+ K DFL++ L G V + G
Sbjct: 1531 -----LRQRFHLTL---SLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 446 GTGVLRSEDP--LTLGNWHELRVS-----RTAKNG-----------ILQVDKQKIVEGM- 486
V+ P L+ G WH + + RT G +L VD + +
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
Query: 487 -----------AEGGFTQIKCNTDI----FIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 531
A G T K + D+ +GGVPN + S K F G ++ + ++
Sbjct: 1643 FGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSH--KDFIGCMRDLHID 1700
Query: 532 DRTIHVKHDFTSG---VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 588
R + + + + H C PC + G C R + CDCP+GF G CQ
Sbjct: 1701 GRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLT 1760
Query: 589 IIEAIEIPQFIGRSYLTYD-NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 647
+ F G L+++ D+ V + + F+T A G+L+ P+S
Sbjct: 1761 MAHP---HHFRGNGTLSWNFGSDMAVSVPW---YLGLAFRTRATQGVLM---QVQAGPHS 1811
Query: 648 DFISLGLRDGALVFSYNLGSGVAS--IMVNGSFNDGRWHRVKAVRDGQSG--------KI 697
+ L G L + GSG AS ++ + +DGRWH ++ + G +
Sbjct: 1812 TLL-CQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMV 1870
Query: 698 TVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 746
++D + + G Q L+VGG+ + + +GLVGCI
Sbjct: 1871 SLDFSLFQDTMAVGSELQGLKVKQLHVGGLPP---GSAEEAPQGLVGCI 1916
Score = 54.3 bits (129), Expect = 4e-07
Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 26/149 (17%)
Query: 547 VENAAHPCVRAPCAHGGSCRPRKE-GYDCDCPLG--FEGLHCQKAIIEAIEIPQFIGRSY 603
++ A CV C +GG+C G+ C CP G FEG C+ A RS+
Sbjct: 1472 LDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVA-----------ARSF 1520
Query: 604 LTYDNPDILKRVSGSRS----NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGAL 659
P G R + + F T + GLL + G + DF++L L G +
Sbjct: 1521 ----PPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNG--RLNEKHDFLALELVAGQV 1574
Query: 660 VFSYNLGSG--VASIMVNGSFNDGRWHRV 686
+Y+ G V S V G +DG+WH V
Sbjct: 1575 RLTYSTGESNTVVSPTVPGGLSDGQWHTV 1603
Score = 50.1 bits (118), Expect = 8e-06
Identities = 68/294 (23%), Positives = 103/294 (35%), Gaps = 33/294 (11%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFF---GHSYVTFEPLK 169
CD C FC WG C C +G GG+ C + + +P F G F
Sbjct: 1726 CDSGPCKNSGFCSE--RWGSFSCDCPVGFGGKDC--QLTMAHPHHFRGNGTLSWNFGSDM 1781
Query: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVA--IIV 227
+ + L FR A G+L+ H + + R L G+G A +++
Sbjct: 1782 AVSVPWYLGLAFRTRATQGVLMQVQAGPHST---LLCQLDRGLLSVTVTRGSGRASHLLL 1838
Query: 228 SETKIKLGGWHTVMLY-------RDGLNGLL-----QLNNGTPVTGQSQGQYSKITFRTP 275
+ + G WH + L R G + L+ L T G S+ Q K+
Sbjct: 1839 DQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVG-SELQGLKV---KQ 1894
Query: 276 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGIC 335
L++GG P A +G GC+Q + + A+ G + C
Sbjct: 1895 LHVGGLPPG----SAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNAC 1950
Query: 336 DEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP 389
C C + ++ C C G+ G C DA L Q + S R P
Sbjct: 1951 ASGPCPPHADCRDL-WQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAP 2003
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 100 bits (248), Expect = 7e-21
Identities = 81/285 (28%), Positives = 127/285 (44%), Gaps = 36/285 (12%)
Query: 112 PCDETLCSADSFCVNDYTWGGSR----CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEP 167
PC E C D CV+ + SR CQC GK GE CS + F G+SY+ +
Sbjct: 3798 PCVEKPCPGDMQCVS---YEASRRPFLCQCPPGKLGE-CSGHTSLS---FAGNSYIKYRL 3850
Query: 168 LKNSYQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAII 226
+NS + F++ L R +G+++Y N + L I+ L F+ +CG+G I+
Sbjct: 3851 SENSKEEDFKLALRLRTLQSNGIIMYTRANP-----CIILKIVDGKLWFQLDCGSGPGIL 3905
Query: 227 -VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAY 285
+S + G WH+V L + L L++ ++ + ++ + +Y G A
Sbjct: 3906 GISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQAD 3965
Query: 286 WL-----VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADV---GECSSGI--- 334
+ R T GFQGC+ S+ +N + ++ K S A+V E G
Sbjct: 3966 NIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQ----NKRSSFAEVVGLTELKLGCVLY 4021
Query: 335 ---CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 376
C + C HGG+CT + + Y C C F GR+CE T P
Sbjct: 4022 PDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFP 4066
Score = 79.3 bits (194), Expect = 1e-14
Identities = 67/293 (22%), Positives = 115/293 (39%), Gaps = 37/293 (12%)
Query: 330 CSSGICD-------EASCIHGGTCTAIKADS--YICLCPLGFKGRHCEDAFTLTIPQFRE 380
C+ G+C E C C + +A ++C CP G G C +L
Sbjct: 3787 CNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGE-CSGHTSL------- 3838
Query: 381 SLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFR 440
S + + L + + R +G+++Y T + + + + G + F+
Sbjct: 3839 SFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMY---TRANPCIILKIVDGKLWFQ 3895
Query: 441 FDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTD 499
DCGSG G+L S + G+WH + + L +D + A F + +
Sbjct: 3896 LDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESS 3955
Query: 500 IFIGGVPNYDDVK-----KNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAH-- 552
I+ G + D+++ + + VL F G + +ILN+ + +++ +S V
Sbjct: 3956 IYFGALVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELK 4015
Query: 553 --------PCVRAPCAHGGSCRPRKE-GYDCDCPLGFEGLHCQKAIIEAIEIP 596
C R+PC HGGSC GY C C F G +C+ I P
Sbjct: 4016 LGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNP 4068
Score = 57.0 bits (136), Expect = 7e-08
Identities = 50/212 (23%), Positives = 87/212 (41%), Gaps = 25/212 (11%)
Query: 553 PCVRAPCAHGGSC---RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 609
PCV PC C + + C CP G G + F G SY+ Y
Sbjct: 3798 PCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLS------FAGNSYIKYRLS 3851
Query: 610 DILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV 669
+ K + +R +T +G++++ +P I L + DG L F + GSG
Sbjct: 3852 ENSKEED---FKLALRLRTLQSNGIIMYTRANPC------IILKIVDGKLWFQLDCGSGP 3902
Query: 670 ASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMK 728
+ ++G + NDG WH V + +++DD ++P + L+ ++Y G +
Sbjct: 3903 GILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALV 3962
Query: 729 EI----ALHTNR--QYMRGLVGCISHFTLSTD 754
+ +L R Q + G GC+ L+ +
Sbjct: 3963 QADNIRSLTDTRVTQVLSGFQGCLDSVILNNN 3994
Score = 35.4 bits (80), Expect = 0.20
Identities = 19/63 (30%), Positives = 30/63 (47%), Gaps = 4/63 (6%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQF-IGR 601
+GV E + C R C +GGSC + C+C G+ G +C + + +P G
Sbjct: 4091 TGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCG---LRPVVVPNIQAGH 4147
Query: 602 SYL 604
SY+
Sbjct: 4148 SYV 4150
Score = 31.6 bits (70), Expect = 2.9
Identities = 11/33 (33%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHC 367
C+ C +GG+C + S++C C G+ G++C
Sbjct: 4102 CEREECENGGSCVNVFG-SFLCNCTPGYVGQYC 4133
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 99.8 bits (247), Expect = 9e-21
Identities = 132/603 (21%), Positives = 240/603 (39%), Gaps = 111/603 (18%)
Query: 157 FFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 214
F G+ + ++ N Q+ +ITL FR +GL+L+ G++ D+++L++ ++
Sbjct: 292 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVW 347
Query: 215 FRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD----------GLNGL-----LQLNNG 256
N G+G + E K WH V + R+ +N L + ++
Sbjct: 348 LVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGI 407
Query: 257 TPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPW 316
TG +Q Y+ + Y+GG+P+ L + +N F GC++ + +
Sbjct: 408 LTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELS 466
Query: 317 PLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 376
L K G ++ D L F+ CED L
Sbjct: 467 RLAK---------------------EGDPKMKLQGD-------LSFR---CEDVAALDPV 495
Query: 377 QFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLLYSYD------TGSK---- 425
F ES ++ A P W + +S + FR +G+LL+S GS
Sbjct: 496 TF-ESPEAFVALPRWSAKRTGSIS-----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQ 549
Query: 426 --DFLSINLAGGHVEFRFDCGSGTGVLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKI 482
D+ ++ L GH+ D GSG LR S + G W + R + G + V+ +
Sbjct: 550 RADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS- 608
Query: 483 VEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-------NSGVLKPFSGSIQKIILNDRTI 535
+A G + +++++GG+P V + + + G ++ + ++ R+
Sbjct: 609 TPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSR 668
Query: 536 HVKH--DFTSGVNV-----ENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQK 587
++ + V V C APC +GG CR + CDC GF G C++
Sbjct: 669 DLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 728
Query: 588 AIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 647
+ + G Y+ P+ + + +V +RF + GL++ + R ++
Sbjct: 729 EAT----VLSYDGSMYMKIMLPNAMHTEA---EDVSLRFMSQRAYGLMM---ATTSRESA 778
Query: 648 DFISLGLRDGALVFSYNL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 698
D + L L G + + NL G ++ ND WH V+ VR G+S +++
Sbjct: 779 DTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLS 838
Query: 699 VDD 701
VD+
Sbjct: 839 VDN 841
Score = 98.2 bits (243), Expect = 3e-20
Identities = 107/437 (24%), Positives = 170/437 (38%), Gaps = 88/437 (20%)
Query: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 460
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
Query: 461 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 519
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
Query: 520 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 571
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
Query: 572 -YDCDCP-LGFEGLHC--------------------------------------QKAIIE 591
CDC GF G C Q +
Sbjct: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGK 285
Query: 592 AIEIPQFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSD 648
+ F G + YD NP + S + + F+T ++GL+L G S +D
Sbjct: 286 EEFVATFKGNEFFCYDLSHNP-----IQSSTDEITLAFRTLQRNGLMLHTGKS-----AD 335
Query: 649 FISLGLRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRDGQSG---------- 695
+++L L+ GA+ NLGSG + VNG FND WH V+ R+ +
Sbjct: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
Query: 696 -----KITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFT 750
I+VD TG + L + Y+GG A +GC+
Sbjct: 396 LHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 455
Query: 751 L-STDYHISLVEDAVDG 766
+ D+ + L A +G
Sbjct: 456 YKNNDFKLELSRLAKEG 472
Score = 97.4 bits (241), Expect = 4e-20
Identities = 145/631 (22%), Positives = 247/631 (39%), Gaps = 84/631 (13%)
Query: 95 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 151
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 675 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 731
Query: 152 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDF 203
+ + G Y+ P +A ++L F ++ GL++ E G
Sbjct: 732 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQ 789
Query: 204 MSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQS 263
M L + L+ G + + K+ WHTV + R G + L ++N T V GQ
Sbjct: 790 MKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQM 848
Query: 264 QGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALS 323
G + ++ F G + + +N F G + L NG+ P
Sbjct: 849 AGAHMRLEFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCK 897
Query: 324 GADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLR 383
D+ C E + G AI AD P+ FK R A +L+
Sbjct: 898 DGDITYC------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQ 935
Query: 384 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 443
+YA+ M F+ + DG+LL++ G+ DF+ I L G++ + FD
Sbjct: 936 AYAS-------------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDL 981
Query: 444 GSGTGVLR--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDI 500
G+G +++ S+ P+ WH + VSR N L++D + + + G + ++
Sbjct: 982 GNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGEL 1039
Query: 501 FIGGVPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHP 553
+IGG+ + ++ K F G + + LN R + D + + +
Sbjct: 1040 YIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT 1099
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 612
C CA+ G C + +G+ CDC + + G C I G + +TY P
Sbjct: 1100 CTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-N 1155
Query: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
R S + + F T + +L+ R DS D++ L + G + +N+G+ +I
Sbjct: 1156 DRPSTRMDRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITI 1213
Query: 673 -MVNGSFNDGRWHRVKAVRDGQSGKITVDDY 702
N +DG++H V+ R G + + VD +
Sbjct: 1214 DEPNAIVSDGKYHVVRFTRSGGNATLQVDSW 1244
Score = 94.4 bits (233), Expect = 4e-19
Identities = 90/343 (26%), Positives = 151/343 (44%), Gaps = 26/343 (7%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 927 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 982
Query: 221 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 983 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1041
Query: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 1042 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1098
Query: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 1099 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1154
Query: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 451
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 1155 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1212
Query: 452 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGF 491
++P + G +H +R +R+ N LQVD + E G F
Sbjct: 1213 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 1255
Score = 90.9 bits (224), Expect = 4e-18
Identities = 146/630 (23%), Positives = 249/630 (39%), Gaps = 124/630 (19%)
Query: 176 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 234
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
Query: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
Query: 295 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 351
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
Query: 352 DSYICLCP-LGFKGRHCEDA---------FTLT--------------------IPQFRES 381
C C GF G+ C + TL + Q +
Sbjct: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKG 284
Query: 382 LRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINL 432
+ AT E Y S E + FR +G++L+ TG S D+++++L
Sbjct: 285 KEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH---TGKSADYVNLSL 341
Query: 433 AGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAKN--GI------------- 474
G V + GSG E N WH++RV+R + GI
Sbjct: 342 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVT 401
Query: 475 LQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRT 534
+ VD G + +T + + +IGG PN D+ S V F G ++ +
Sbjct: 402 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADL-PGSPVSNNFMGCLKDV------ 454
Query: 535 IHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAI 593
++ +DF ++ R KEG D + +G L + + A+
Sbjct: 455 VYKNNDFKLELS-------------------RLAKEG---DPKMKLQGDLSFRCEDVAAL 492
Query: 594 EIPQFIGRSYLTYDNPD---ILKRVSGSRS-NVFMRFKTTAKDGLLLW---------RGD 640
+ +T+++P+ L R S R+ ++ + F+TT +GLLL+ G
Sbjct: 493 D--------PVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 544
Query: 641 SPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG-SFNDGRWHRVKAVRDGQSGKITV 699
+D+ ++ L DG L ++GSG + + NDG W V RDG+ G I+V
Sbjct: 545 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISV 604
Query: 700 DDYGARTGKSPGMMRQLNINGALYVGGMKE 729
+ + + G L++ LY+GG+ E
Sbjct: 605 NS-RSTPFLATGDSEILDLESELYLGGLPE 633
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/375 (26%), Positives = 153/375 (40%), Gaps = 55/375 (14%)
Query: 163 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 204
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 495 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 554
Query: 205 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 262
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 555 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 612
Query: 263 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 315
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 613 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR- 671
Query: 316 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 370
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 672 -GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCER- 728
Query: 371 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 430
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 729 -EATVLSYDGSMYMKIMLPNAM----HTEAEDVSLRFMSQRAYGLMMATTSRESADTLRL 783
Query: 431 NLAGGHVEF--RFDCGSGTGVLRSEDPLTL--------GNWHELRVSRTAKNGILQVDKQ 480
L GG ++ DC G S+ P TL WH +RV R K+ L VD
Sbjct: 784 ELDGGQMKLTVNLDC-LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-N 841
Query: 481 KIVEGMAEGGFTQIK 495
VEG G +++
Sbjct: 842 VTVEGQMAGAHMRLE 856
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 678
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 941 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 996
Query: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 997 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1046
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/224 (23%), Positives = 84/224 (37%), Gaps = 28/224 (12%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 170
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 1100 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1157
Query: 171 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 228
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 1158 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1216
Query: 229 ETKIKLGGWHTVMLYRDGLNGLLQ-----LNNGTPVTGQSQGQYSKITFRTPLYLGGAPS 283
+ G +H V R G N LQ +N P + + R P LG
Sbjct: 1217 NAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVD 1276
Query: 284 AYWL--------------VRATGTNRG--FQGCVQSLAVNGRRI 311
+ L ++ G ++G FQG V L NG ++
Sbjct: 1277 EWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
Score = 43.9 bits (102), Expect = 6e-04
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 616 SGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGV-ASIMV 674
+ S + +T A LLL+ D + DF+ L L DG L + L A++ +
Sbjct: 47 AASSGELSFSLRTNATRALLLYLDDGG---DCDFLELLLVDGRLRLRFTLSCAEPATLQL 103
Query: 675 NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 727
+ D RWH V RD + + VD AR + R++ + L+VGG+
Sbjct: 104 DTPVADDRWHMVLLTRDARRTALAVDG-EARAAEVRSKRREMQVASDLFVGGI 155
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 97.1 bits (240), Expect = 6e-20
Identities = 125/545 (22%), Positives = 197/545 (36%), Gaps = 96/545 (17%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVI-QYPQFFGHSYVTFEPLKNS 171
C+ C + C+N W +C C G +C + V ++ Q YV F ++
Sbjct: 676 CESQPCQSRGRCIN--LWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESY 733
Query: 172 YQAFQITLEFRAEAEDGLLLYCGENEHG-------RGDFMSLAIIRRSLQFRFNCGTGVA 224
+++ R GLLL + + RG L L +F G
Sbjct: 734 GDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFVLNDGNV 793
Query: 225 IIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSA 284
++S KIK + + LY+ N G KI +Y+GG P
Sbjct: 794 HLIS-LKIKP---YKIELYQSSQN-----------LGFISASTWKIEKGDVIYIGGLPDK 838
Query: 285 YWLVRATGTNRGF-QGCVQSLAVNGRRIDMRPWPLGKA-----LSGADVGECSSGICDEA 338
+ T N GF +GC+Q + +N + ++ P P A L G C
Sbjct: 839 ----QETELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSN 894
Query: 339 SCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 398
C +GG C + + D + C CP G+ CE+ ++ P + Q L
Sbjct: 895 PCHNGGVCHS-RWDDFSCSCPALTSGKACEEV----------QWCGFSPCPHGAQCQPVL 943
Query: 399 SFMEF--------------------------EITFRPDSGDGVLLYSYDTGSKDFLSINL 432
E ITF + D ++ + +FL+I++
Sbjct: 944 QGFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHAEKEPEFLNISI 1003
Query: 433 AGGHVEFRFDCGSGTGVLR--SEDPLTLGNWHELRVSRT-----AKNGILQVDKQK--IV 483
+ F+ G+ +L S + G WHE+ +S T ++VD + +
Sbjct: 1004 QDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVT 1063
Query: 484 EGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILND-RTIH------ 536
+A G +K NTDI++G D++K G L I I L+ +H
Sbjct: 1064 STIATGSLNFLKDNTDIYVGDRA-IDNIKGLQGCLSTIE--IGGIYLSYFENVHGFINKP 1120
Query: 537 -----VKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 591
+K S V + C PC HGG+C Y C CPLG+ G HC+ I E
Sbjct: 1121 QEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDE 1180
Query: 592 AIEIP 596
P
Sbjct: 1181 CFSNP 1185
Score = 76.3 bits (186), Expect = 1e-13
Identities = 147/700 (21%), Positives = 253/700 (36%), Gaps = 95/700 (13%)
Query: 113 CDETLCSADSFCVNDYTWG--GSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN 170
C C + C+ + G G C C G G C + + + G +V +
Sbjct: 445 CTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSF-EGDGFLWVKSGSVTT 503
Query: 171 SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRR--SLQFRFNCGTGVAIIVS 228
I L F+ LLL+ R F+ L ++ L + N + V + +S
Sbjct: 504 KGSVCNIALRFQTVQPMALLLF----RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFIS 559
Query: 229 ETKIKLGGWH----------TVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
G WH T+ L D TP+ + +F L +
Sbjct: 560 HNTSD-GEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPV 618
Query: 279 GGAPSAYWLVRATG--TNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 336
G + L+ + F GC+Q + ++ I + G +L+ G C+
Sbjct: 619 GMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLN-VKAGCVRKDWCE 677
Query: 337 EASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQF-RESLRSYAATPWPLEPQ 395
C G C + SY C C ++G +C + +F ++ Y
Sbjct: 678 SQPCQSRGRCINLWL-SYQCDCHRPYEGPNCLREYVAG--RFGQDDSTGYVIFTLDESYG 734
Query: 396 HYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP 455
+S F T +P LL + + + ++ + L G + + L +
Sbjct: 735 DTISLSMFVRTLQPSG----LLLALENSTYQYIRVWLERGRLAM---LTPNSPKLVVKFV 787
Query: 456 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 515
L GN H + + L Q + G +I+ I+IGG+P+ + + N
Sbjct: 788 LNDGNVHLISLKIKPYKIELYQSSQNL--GFISASTWKIEKGDVIYIGGLPDKQETELNG 845
Query: 516 GVLKPFSGSIQKIILNDRTIHVKHDFTSG-------VNVENAA---HPCVRAPCAHGGSC 565
G F G IQ + LN++ + + T+ VNV + C PC +GG C
Sbjct: 846 GF---FKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVC 902
Query: 566 RPRKEGYDCDCP-------------LGF----EGLHCQKAI--IEAIEIPQFIGRS--YL 604
R + + C CP GF G CQ + E I F G+S L
Sbjct: 903 HSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQIL 962
Query: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
N +I + + +N+ F+T + ++L P +F+++ ++D L F
Sbjct: 963 FRSNGNITREL----TNITFGFRTRDANVIILHAEKEP-----EFLNISIQDSRLFFQLQ 1013
Query: 665 LGSG--VASIMVNGSFNDGRWHRV-----KAVRDGQSGKITVDDYG--ARTGKSPGMMRQ 715
G+ + S+ S NDG WH V + ++ VD+ + + G +
Sbjct: 1014 SGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNF 1073
Query: 716 LNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDY 755
L N +YVG + A+ ++GL GC+S + Y
Sbjct: 1074 LKDNTDIYVG---DRAIDN----IKGLQGCLSTIEIGGIY 1106
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/296 (24%), Positives = 118/296 (39%), Gaps = 45/296 (15%)
Query: 100 NGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRC----QCTLGKGGESCSEDIVIQYP 155
NG SR D C ++ C G S C QC G C + V
Sbjct: 898 NGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAV---- 953
Query: 156 QFFGHS-YVTFEPLKN-SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSL 213
F G S + F N + + IT FR + ++L+ + +F++++I L
Sbjct: 954 -FNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHAEKEP----EFLNISIQDSRL 1008
Query: 214 QFRFNCGTGVAII--VSETKIKLGGWHTVML-YRDGLNGL----LQLNNGTPVTGQS--Q 264
F+ G ++ S + G WH V L D L+ ++++N TP +
Sbjct: 1009 FFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIAT 1068
Query: 265 GQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM---------RP 315
G + + T +Y+G RA +G QGC+ ++ + G + +P
Sbjct: 1069 GSLNFLKDNTDIYVGD--------RAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKP 1120
Query: 316 WP---LGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
L + + G +C+ C+HGG C I + SY C CPLG+ G+HCE
Sbjct: 1121 QEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCEDIYS-SYHCSCPLGWSGKHCE 1175
Score = 59.3 bits (142), Expect = 1e-08
Identities = 82/386 (21%), Positives = 131/386 (33%), Gaps = 97/386 (25%)
Query: 329 ECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCEDAFTLTIPQ-------FRE 380
E ++ C C+HGG C + Y C C GF G HCE L + +
Sbjct: 260 ELNTDECASQPCLHGGLCVD-GENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCED 318
Query: 381 SLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLL-------YSYDTGSKDFLSINLA 433
S+ +Y WP E P +G + Y TG S + A
Sbjct: 319 SVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEA 378
Query: 434 GGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQ 493
G+V C + + GFT
Sbjct: 379 SGYV-----C------------------------------------------ICQPGFTG 391
Query: 494 IKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVE 548
I C D+ + +N G + G+ T H D F G +
Sbjct: 392 IHCEEDV----NECSSNPCQNGGTCENLPGNY--------TCHCPFDNLSRTFYGGRDCS 439
Query: 549 NAAHPCVRAPCAHGGSCRPR----KEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYL 604
+ C C + G+C P + G+ C CP G+ G C+ A + E G +L
Sbjct: 440 DILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFE-----GDGFL 494
Query: 605 TYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYN 664
+ + + GS N+ +RF+T LLL+R + + F+ L L G + S
Sbjct: 495 WVKSGSVTTK--GSVCNIALRFQTVQPMALLLFRSNRDV-----FVKLELLSGYIHLSIQ 547
Query: 665 LGS-GVASIMVNGSFNDGRWHRVKAV 689
+ + + ++ + +DG WH V+ +
Sbjct: 548 VNNQSKVLLFISHNTSDGEWHFVEVI 573
Score = 53.9 bits (128), Expect = 6e-07
Identities = 114/527 (21%), Positives = 187/527 (35%), Gaps = 90/527 (17%)
Query: 254 NNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATG----TNRGFQG---------C 300
+NG V S+ QY +IT G PS++ A+G GF G C
Sbjct: 350 SNGECVELSSEKQYGRIT--------GLPSSFSYHEASGYVCICQPGFTGIHCEEDVNEC 401
Query: 301 VQSLAVNGRRIDMRPWP---------LGKALSGADVGECSSGI--CDEASCIHGGTCTAI 349
+ NG + P L + G +CS + C C++ GTC
Sbjct: 402 SSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGR--DCSDILLGCTHQQCLNNGTCIPH 459
Query: 350 KADS---YICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEIT 406
D + CLCP G+ G CE A TL+ W I
Sbjct: 460 FQDGQHGFSCLCPSGYTGSLCEIATTLSFEG--------DGFLWVKSGSVTTKGSVCNIA 511
Query: 407 FRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-GNWHELR 465
R + + L + + F+ + L G++ + + VL T G WH +
Sbjct: 512 LRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVE 571
Query: 466 VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDI------FIGGVP-----------NY 508
V + +D + +A+ T ++ + I F+GG+P N+
Sbjct: 572 VIFAEAVTLTLIDDSCKEKCIAKAP-TPLESDQSICAFQNSFLGGLPVGMTSNGVALLNF 630
Query: 509 DDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRA------PCAHG 562
++ F G +Q I ++ I +++ +SG ++ N CVR PC
Sbjct: 631 YNMPSTPS----FVGCLQDIKIDWNHITLEN-ISSGSSL-NVKAGCVRKDWCESQPCQSR 684
Query: 563 GSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNV 622
G C Y CDC +EG +C + + A Q Y+ + L G ++
Sbjct: 685 GRCINLWLSYQCDCHRPYEGPNCLREYV-AGRFGQDDSTGYVIF----TLDESYGDTISL 739
Query: 623 FMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGR 682
M +T GLLL +S + +I + L G L L ++V NDG
Sbjct: 740 SMFVRTLQPSGLLLALENSTYQ----YIRVWLERGRLAM---LTPNSPKLVVKFVLNDGN 792
Query: 683 WHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
H + + KI + G ++ +Y+GG+ +
Sbjct: 793 VHLISL--KIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPD 837
Score = 43.9 bits (102), Expect = 6e-04
Identities = 19/44 (43%), Positives = 23/44 (52%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
SGVN E C PC +G +C+ Y CDC GF G HC+
Sbjct: 217 SGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCE 260
Score = 41.2 bits (95), Expect = 0.004
Identities = 15/43 (34%), Positives = 22/43 (51%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
C +PC +G C+ +GY C C G++G HC + E P
Sbjct: 152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDP 194
Score = 39.3 bits (90), Expect = 0.014
Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 4/71 (5%)
Query: 298 QGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICL 357
QG + G R + P G + + E + G C + SC HGG C +C+
Sbjct: 80 QGSATCVNTPGERSFLCKCPPGYS---GTICETTIGSCGKNSCQHGGICHQDPIYP-VCI 135
Query: 358 CPLGFKGRHCE 368
CP G+ GR CE
Sbjct: 136 CPAGYAGRFCE 146
Score = 38.9 bits (89), Expect = 0.018
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 544 GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQ 586
G + E C PC HGG C + Y C+C GF G HC+
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299
Score = 35.0 bits (79), Expect = 0.27
Identities = 16/46 (34%), Positives = 22/46 (47%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 588
+GVN E C CA+G +C GY C C F G C+++
Sbjct: 1207 TGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQS 1252
Score = 34.3 bits (77), Expect = 0.45
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 6/43 (13%)
Query: 326 DVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
D EC+S C + G D Y C C G++GRHC+
Sbjct: 148 DHDECASSPCQNGAVCQDGI------DGYSCFCVPGYQGRHCD 184
Score = 33.9 bits (76), Expect = 0.59
Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 6/43 (13%)
Query: 326 DVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
D+ EC+S C++GG C + + + CLC + F G CE
Sbjct: 1297 DIDECASD-----PCVNGGLCQDL-LNKFQCLCDVAFAGERCE 1333
Score = 33.1 bits (74), Expect = 1.0
Identities = 15/44 (34%), Positives = 18/44 (40%)
Query: 543 SGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
SG E C + C HGG C C CP G+ G C+
Sbjct: 103 SGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Score = 33.1 bits (74), Expect = 1.0
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 14/58 (24%)
Query: 326 DVGECSSGICDE-ASCIH------GGTCTAI-------KADSYICLCPLGFKGRHCED 369
D+ EC+S C C+ G T + +A Y+C+C GF G HCE+
Sbjct: 339 DLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEE 396
Score = 32.3 bits (72), Expect = 1.7
Identities = 11/33 (33%), Positives = 16/33 (48%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQ 586
C PC +GG C+ + C C + F G C+
Sbjct: 1301 CASDPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/44 (34%), Positives = 25/44 (56%), Gaps = 8/44 (18%)
Query: 326 DVGECSSGIC-DEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
+V EC+S C +EA+C++ + Y C+CP + G +CE
Sbjct: 186 EVDECASDPCKNEATCLN-------EIGRYTCICPHNYSGVNCE 222
Score = 32.0 bits (71), Expect = 2.2
Identities = 14/34 (41%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
C C++G TC +Y C C GF G HCE
Sbjct: 228 CWSQPCLNGATCQDALG-AYFCDCAPGFLGDHCE 260
Score = 31.6 bits (70), Expect = 2.9
Identities = 13/43 (30%), Positives = 19/43 (44%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
C PC + +C Y C CP + G++C+ I E P
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQP 232
Score = 30.0 bits (66), Expect = 8.5
Identities = 12/30 (40%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 339 SCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
+C +GG CT + + C+C GF G CE
Sbjct: 1267 TCYNGGNCTEFQTELK-CMCRPGFTGEWCE 1295
Score = 30.0 bits (66), Expect = 8.5
Identities = 14/38 (36%), Positives = 18/38 (47%)
Query: 559 CAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIP 596
C +GG+C + C C GF G C+K I E P
Sbjct: 1268 CYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDP 1305
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 92.4 bits (228), Expect = 1e-18
Identities = 82/306 (26%), Positives = 133/306 (43%), Gaps = 55/306 (17%)
Query: 112 PCDETLCSADSFCVNDYTWGGSR--CQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLK 169
PC+ T C + CV+ G+R CQC G GG C + + + + +Y+ F L+
Sbjct: 1130 PCEGTECQNGANCVDQ----GNRPVCQCLPGFGGPECEKLLSVNFVD--RDTYLQFTDLQ 1183
Query: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT--GVAIIV 227
N +A ITL+ ++G+LLY G+N+H +++ + + ++ ++ G+ AI
Sbjct: 1184 NWPRA-NITLQVSTAEDNGILLYNGDNDH-----IAVELYQGHVRVSYDPGSYPSSAIYS 1237
Query: 228 SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP----S 283
+ET I G +HTV L L ++ G+P+T + G++ + PLY+GG P S
Sbjct: 1238 AET-INDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNS 1296
Query: 284 AYWLVRATGTNRGFQGCVQSLAVNGRRIDMR----------------------------- 314
A + + GF GC+++L +N D
Sbjct: 1297 AAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNA 1356
Query: 315 -PWPLGKALSGADVGEC---SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDA 370
P P+ +G C + G C C+HG C + A SY C C G+ G C A
Sbjct: 1357 TPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQA 1415
Query: 371 FTLTIP 376
L P
Sbjct: 1416 GALAEP 1421
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 18/177 (10%)
Query: 553 PCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDI 611
PC C +G +C + C C GF G C+K + F+ R +YL + +
Sbjct: 1130 PCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSV-----NFVDRDTYLQFTDLQ- 1183
Query: 612 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 671
+ R+N+ ++ T +G+LL+ GD+ D I++ L G + SY+ GS +S
Sbjct: 1184 ----NWPRANITLQVSTAEDNGILLYNGDN------DHIAVELYQGHVRVSYDPGSYPSS 1233
Query: 672 IMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 727
+ + + NDG++H V+ V Q +++D T + G LN LYVGGM
Sbjct: 1234 AIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGM 1290
Score = 67.4 bits (163), Expect = 5e-11
Identities = 63/266 (23%), Positives = 107/266 (40%), Gaps = 34/266 (12%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
C+ C +G C + + +C C GF G CE ++ L+ WP
Sbjct: 1131 CEGTECQNGANCVD-QGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPR-- 1187
Query: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVLRSE 453
+ + +++ D+G +LLY+ G D +++ L GHV +D GS + + S
Sbjct: 1188 ----ANITLQVSTAEDNG--ILLYN---GDNDHIAVELYQGHVRVSYDPGSYPSSAIYSA 1238
Query: 454 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 513
+ + G +H + + + L +D + G + +++GG+P V
Sbjct: 1239 ETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMP----VDV 1294
Query: 514 NSGVLK--------PFSGSIQKIILNDRTIHVKHDFTSGV---NVENAAHPCVRAPCAHG 562
NS + F G I+ + +N+ DFT V PC + C HG
Sbjct: 1295 NSAAFRLWQILNGTGFHGCIRNLYINNEL----QDFTKTQMKPGVVPGCEPCRKLYCLHG 1350
Query: 563 GSCRPRKE-GYDCDCPLGFEGLHCQK 587
C+P G C C G+ GLHC +
Sbjct: 1351 -ICQPNATPGPMCHCEAGWVGLHCDQ 1375
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 4/48 (8%)
Query: 542 TSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAI 589
T GVN ++ CV CA+GG C Y C CPL +EG C++ +
Sbjct: 1001 TCGVNTDD----CVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
Score = 39.7 bits (91), Expect = 0.011
Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 10/133 (7%)
Query: 246 GLNGLLQLN-NGTPVTGQSQGQYSKITFRTPLYLGGAP-----SAYWL---VRATGTNRG 296
GL L L+ +G ++ +G ++ +T + L +G P WL V+ G
Sbjct: 830 GLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPG 889
Query: 297 FQGCVQSLAVNGRRIDMRPWPLGKALSGADVG-ECSSGICDEASCIHGGTCTAIKADSYI 355
C + G+ + P + + + +C + C + GTC + Y
Sbjct: 890 IARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYR 949
Query: 356 CLCPLGFKGRHCE 368
C CP G+KGR CE
Sbjct: 950 CACPSGYKGRDCE 962
Score = 37.7 bits (86), Expect = 0.041
Identities = 19/46 (41%), Positives = 24/46 (52%), Gaps = 5/46 (10%)
Query: 544 GVNVENAAHPCVRAPCAHGGSCRPRKEGYD----CDCPLGFEGLHC 585
G + E + C PC +GG+C + EG D C CP GFEG C
Sbjct: 958 GRDCEVSLDSCSSGPCENGGTCHAQ-EGEDAPFTCSCPTGFEGPTC 1002
Score = 35.8 bits (81), Expect = 0.16
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 2/41 (4%)
Query: 329 ECSSGICDEASCIHGGTCTAIKADS--YICLCPLGFKGRHC 367
E S C C +GGTC A + + + C CP GF+G C
Sbjct: 962 EVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTC 1002
Score = 35.8 bits (81), Expect = 0.16
Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 1/42 (2%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIP 376
C + +C +GG C +Y C CPL ++G+ CE L P
Sbjct: 1009 CVDHACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLCSP 1049
Score = 33.9 bits (76), Expect = 0.59
Identities = 13/37 (35%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 554 CVRAPCAHGGSCRPRK-EGYDCDCPLGFEGLHCQKAI 589
C+ +PC + G+C E Y C CP G++G C+ ++
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
Score = 31.6 bits (70), Expect = 2.9
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 9/59 (15%)
Query: 93 PIQRKGKNGVAIMSRLFDMPCDETL--CSADSFCVNDYTWGGSRCQCTLGKGGESCSED 149
P+Q +GK +L D+ C L C ++ CV T G RC+C G G++CSE+
Sbjct: 1032 PLQYEGK----ACEQLVDL-CSPDLNPCQHEAQCVG--TPDGPRCECMPGYAGDNCSEN 1083
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 88.6 bits (218), Expect = 2e-17
Identities = 71/274 (25%), Positives = 114/274 (41%), Gaps = 35/274 (12%)
Query: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSY 172
C++ C S CV+D C C G+ G+ + G+SYV + +N
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMT----LTGNSYVKYRLTENEN 3849
Query: 173 QA-FQITLEFRAEAEDGLLLYCGENEHGRG-DFMSLAIIRRSLQFRFNCGTGVAII-VSE 229
+ ++T+ R + +++Y RG D+ L I LQ++F+CG+G I+ V
Sbjct: 3850 KLEMKLTMRLRTYSTHAVVMYA------RGTDYSILEIHHGRLQYKFDCGSGPGIVSVQS 3903
Query: 230 TKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 289
++ G WH V L +G L L+ +G + G + ++ GG +R
Sbjct: 3904 IQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGH------IR 3957
Query: 290 ATGTNRG--------FQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI------- 334
GT G F+GC+ S+ +NG+ + + P A V + S G
Sbjct: 3958 QQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESV-DVSPGCFLTATED 4016
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
C C +GG C A Y C C + G HCE
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCE 4050
Score = 83.2 bits (204), Expect = 8e-16
Identities = 65/271 (23%), Positives = 115/271 (42%), Gaps = 27/271 (9%)
Query: 335 CDEASCIHGGTCTAIK-ADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLE 393
C++ C G C + + + C+CP G G+ C + ++T+ S Y T E
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ-CPGSSSMTLTG--NSYVKYRLT----E 3846
Query: 394 PQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSE 453
++ L M+ + R S V++Y+ T D+ + + G ++++FDCGSG G++ +
Sbjct: 3847 NENKLE-MKLTMRLRTYSTHAVVMYARGT---DYSILEIHHGRLQYKFDCGSGPGIVSVQ 3902
Query: 454 D-PLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVK 512
+ G WH + + L +D+ G A G + + +F GG +
Sbjct: 3903 SIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTR 3962
Query: 513 --KNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE-----------NAAHPCVRAPC 559
++ V F G + I LN + + + S ++E A C PC
Sbjct: 3963 HGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPC 4022
Query: 560 AHGGSCRPRKE-GYDCDCPLGFEGLHCQKAI 589
+GG C P GY C C + G HC+ ++
Sbjct: 4023 QNGGVCNPSPAGGYYCKCSALYIGTHCEISV 4053
Score = 65.9 bits (159), Expect = 1e-10
Identities = 52/208 (25%), Positives = 92/208 (44%), Gaps = 23/208 (11%)
Query: 552 HPCVRAPCAHGGSC--RPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNP 609
H C PC G C P +E + C CP G G C + + G SY+ Y
Sbjct: 3792 HGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFG-QCPGSSSMTLT-----GNSYVKYR-- 3843
Query: 610 DILKRVSGSRSNVFMRFKTTAKDGLLLW-RGDSPMRPNSDFISLGLRDGALVFSYNLGSG 668
+ + + + MR +T + ++++ RG +D+ L + G L + ++ GSG
Sbjct: 3844 -LTENENKLEMKLTMRLRTYSTHAVVMYARG-------TDYSILEIHHGRLQYKFDCGSG 3895
Query: 669 VASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG- 726
+ V NDG+WH V +G ++ +D +G +PG ++ LN++ ++ GG
Sbjct: 3896 PGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGH 3955
Query: 727 MKEIALHTNR--QYMRGLVGCISHFTLS 752
+++ R Q G GC+ L+
Sbjct: 3956 IRQQGTRHGRSPQVGNGFRGCMDSIYLN 3983
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/66 (34%), Positives = 30/66 (45%), Gaps = 16/66 (24%)
Query: 325 ADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRS 384
+D+ ECS C+HG C SY C C ++GRHCEDA +
Sbjct: 4126 SDIDECSGN-----PCLHGALCENTHG-SYHCNCSHEYRGRHCEDA----------APNQ 4169
Query: 385 YAATPW 390
Y +TPW
Sbjct: 4170 YVSTPW 4175
Score = 37.7 bits (86), Expect = 0.041
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 554 CVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIE 591
C PC +GG+C +G C C GF G CQ I E
Sbjct: 4093 CKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130
Score = 36.2 bits (82), Expect = 0.12
Identities = 14/45 (31%), Positives = 19/45 (42%)
Query: 544 GVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKA 588
G ++ C PC HG C Y C+C + G HC+ A
Sbjct: 4121 GERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDA 4165
Score = 33.9 bits (76), Expect = 0.59
Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 332 SGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCE 368
S C + C +GGTC D +C C GF+G C+
Sbjct: 4090 SPYCKDEPCKNGGTCFD-SLDGAVCQCDSGFRGERCQ 4125
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo
sapiens]
Length = 1331
Score = 87.8 bits (216), Expect = 3e-17
Identities = 106/433 (24%), Positives = 180/433 (41%), Gaps = 66/433 (15%)
Query: 177 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG-VAIIVSETKIKLG 235
I L F+ +G++L+ GE + +GD+++L + + L N G+ + I T + G
Sbjct: 212 IALNFKTSESEGVILH-GEGQ--QGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTG 268
Query: 236 G------WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 289
WH+V++ R G + L L+ ++ G++ + + GG P +
Sbjct: 269 SLLDDHHWHSVVIERQGRSINLTLDRSMQHF-RTNGEFDYLDLDYEITFGGIPFSG--KP 325
Query: 290 ATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTA- 348
++ + + F+GC++S+ NG +++ K L ++VG S SC+ T
Sbjct: 326 SSSSRKNFKGCMESINYNG--VNITDLARRKKLEPSNVGNLS------FSCVEPYTVPVF 377
Query: 349 IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFR 408
A SY L GR +D F+++ QFR W P L F F
Sbjct: 378 FNATSY-----LEVPGRLNQDLFSVSF-QFR---------TW--NPNGLLVFSHF----- 415
Query: 409 PDSGDGVLLYSYD-TGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVS 467
D + D T SK + IN+ + + D SG+G L G WHE+R
Sbjct: 416 ---ADNLGNVEIDLTESKVGVHINITQTKMS-QIDISSGSG-------LNDGQWHEVRFL 464
Query: 468 RTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQK 527
IL +D + + Q+K F GG N + +S + F G +Q
Sbjct: 465 AKENFAILTIDGDE-ASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQL 523
Query: 528 IILNDRTIHV------KHDFTSGVNVENAA--HPCVRAPCAHGGSCRPRKEGYDCDC-PL 578
I ++D+ +++ K + V+++ A CV C HGG C + + C C
Sbjct: 524 IQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDET 583
Query: 579 GFEGLHCQKAIIE 591
G+ G C +I E
Sbjct: 584 GYSGATCHNSIYE 596
Score = 80.9 bits (198), Expect = 4e-15
Identities = 99/396 (25%), Positives = 163/396 (41%), Gaps = 63/396 (15%)
Query: 394 PQHYLSFMEFE--------ITFRPDSGDGVLLYSYDTGSKDFLSINLAGG-HVEFRFDCG 444
P YL F F+ F+ + GV L + G +DF+ + L V F FD G
Sbjct: 806 PSSYLHFSTFQGETSADISFYFKTLTPWGVFLENM--GKEDFIKLELKSATEVSFSFDVG 863
Query: 445 SGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDK--QKIVEGMAEGGFTQIKCNTDI 500
+G V+RS PL WH + R K LQVD+ Q+I + EG T+++ + +
Sbjct: 864 NGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEG-HTRLELYSQL 922
Query: 501 FIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNVENAAHPCVR-- 556
F+GG +G + F G I+ + +N T+ ++ TSG + + C
Sbjct: 923 FVGG----------AGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGF-ISGCSGHCTSYG 971
Query: 557 APCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRV 615
C +GG C R GY CDC ++G C K + E ++ + P R
Sbjct: 972 TNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWL---RYNFQAPATNARD 1028
Query: 616 SGSR----------------SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLR-DGA 658
S SR + F TT +LL+ +DF+++ ++ G+
Sbjct: 1029 SSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSF----TTDFLAVLVKPTGS 1084
Query: 659 LVFSYNLGSGVASIMV---NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQ 715
L YNLG + + + +G+ H V R ++ + +D Y + + P
Sbjct: 1085 LQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDT 1144
Query: 716 L-NINGALYVGGMKE---IALHTNRQYMRGLVGCIS 747
L N +L++G + E I ++ G GC+S
Sbjct: 1145 LFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLS 1180
Score = 52.4 bits (124), Expect = 2e-06
Identities = 81/344 (23%), Positives = 136/344 (39%), Gaps = 48/344 (13%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS-LQFRFNC 219
SY+ F + A I+ F+ G+ L G+ DF+ L + + + F F+
Sbjct: 808 SYLHFSTFQGETSA-DISFYFKTLTPWGVFL----ENMGKEDFIKLELKSATEVSFSFDV 862
Query: 220 GTGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQ-YSKITFRTPL 276
G G IV S T + WH V R+ LQ++ ++ + ++++ + L
Sbjct: 863 GNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQL 922
Query: 277 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 336
++GGA G +GF GC++SL +NG +D+ K SG G SG C
Sbjct: 923 FVGGA----------GGQQGFLGCIRSLRMNGVTLDLE--ERAKVTSGFISG--CSGHCT 968
Query: 337 E--ASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------------AFTLTIPQFR 379
+C +GG C + Y C C + G C F R
Sbjct: 969 SYGTNCENGGKCLE-RYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNAR 1027
Query: 380 ESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINL-AGGHVE 438
+S P L+ E +F +LLY + + DFL++ + G ++
Sbjct: 1028 DSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLY-ISSFTTDFLAVLVKPTGSLQ 1086
Query: 439 FRFDCGSGTGVLRSED----PLTLGNWHELRVSRTAKNGILQVD 478
R++ G GT + D + G H + ++R K L++D
Sbjct: 1087 IRYNLG-GTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLD 1129
Score = 47.8 bits (112), Expect = 4e-05
Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 11/95 (11%)
Query: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS----- 667
K++ + + + FKT+ +G++L G+ D+I+L L+ LV S NLGS
Sbjct: 203 KKMKTLKDVIALNFKTSESEGVIL-HGEGQQ---GDYITLELKKAKLVLSLNLGSNQLGP 258
Query: 668 --GVASIMVNGSFNDGRWHRVKAVRDGQSGKITVD 700
G S+M +D WH V R G+S +T+D
Sbjct: 259 IYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLD 293
Score = 42.7 bits (99), Expect = 0.001
Identities = 62/307 (20%), Positives = 116/307 (37%), Gaps = 56/307 (18%)
Query: 405 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT-GVLRSEDPLTLGN--- 460
+ F+ +GV+L+ + D++++ L + + GS G + + G+
Sbjct: 214 LNFKTSESEGVILHG-EGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLD 272
Query: 461 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 517
WH + + R ++ L +D+ + G F + + +I GG+P K +S
Sbjct: 273 DHHWHSVVIERQGRSINLTLDRS-MQHFRTNGEFDYLDLDYEITFGGIPFSG--KPSSSS 329
Query: 518 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 577
K F G ++ I N GVN+ + A P G + C
Sbjct: 330 RKNFKGCMESINYN------------GVNITDLARRKKLEPSNVGNL------SFSC--- 368
Query: 578 LGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLL 636
+E +P F SYL ++ R++ +V +F+T +GLL+
Sbjct: 369 ------------VEPYTVPVFFNATSYL-----EVPGRLNQDLFSVSFQFRTWNPNGLLV 411
Query: 637 WRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS---IMVNGSFNDGRWHRVKAVRDGQ 693
+ S N + + L + + N+ S I NDG+WH V+ +
Sbjct: 412 F---SHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKEN 468
Query: 694 SGKITVD 700
+T+D
Sbjct: 469 FAILTID 475
Score = 39.3 bits (90), Expect = 0.014
Identities = 52/241 (21%), Positives = 92/241 (38%), Gaps = 29/241 (12%)
Query: 145 SCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFM 204
SC E + P FF + P + + F ++ +FR +GLL++ H +
Sbjct: 367 SCVEPYTV--PVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVF----SHFADNLG 420
Query: 205 SLAIIRRSLQFRFNCGTGVAIIVSETKIKL-----------GGWHTVMLYRDGLNGLLQL 253
++ I + GV I +++TK+ G WH V +L +
Sbjct: 421 NVEIDLTESK------VGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTI 474
Query: 254 NNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM 313
+G + ++ + GG + + FQGC+Q + V+ + +++
Sbjct: 475 -DGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNL 533
Query: 314 RPWPLGKALSGADVGECSSGICDEA---SCIHGGTCTAIKADSYICLC-PLGFKGRHCED 369
K S A+V I D C HGG C+ DS+ C C G+ G C +
Sbjct: 534 YEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQ-TWDSFKCTCDETGYSGATCHN 592
Query: 370 A 370
+
Sbjct: 593 S 593
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 87.4 bits (215), Expect = 5e-17
Identities = 88/334 (26%), Positives = 142/334 (42%), Gaps = 47/334 (14%)
Query: 397 YLSFMEFEITFRPDSG--------DGVLLYSYDTGSKDFLSINLAG-GHVEFRFDCGSGT 447
YL F F F D GV L + G KDF+ + ++ + F D G+G
Sbjct: 801 YLHFPTFHAEFSADISFFFKTTALSGVFLENL--GIKDFIRLEISSPSEITFAIDVGNGP 858
Query: 448 GVLRSEDPLTLGN--WHELRVSRTAKNGILQVDK-QKIVEGMAEGGFTQIKCNTDIFIGG 504
L + P L + WH +R R K LQVD + +E G +++ N+ +F+GG
Sbjct: 859 VELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGG 918
Query: 505 VPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNVENAAH-PCVRAPCAH 561
S K F G I+ + LN + + ++ TSGV H + C +
Sbjct: 919 T---------SSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHN 969
Query: 562 GGSCRPRKEGYDCDCPLG-FEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS---- 616
GG C + GY CDC +EG C+K + E + +Y+ + + K +S
Sbjct: 970 GGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSV--TYMFQEPYPVTKNISLSSS 1027
Query: 617 -------GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSG 668
S+ N+ + F TT LLL+ S + DF+ + L ++G+L Y+L
Sbjct: 1028 AIYTDSAPSKENIALSFVTTQAPSLLLFINSS----SQDFVVVLLCKNGSLQVRYHLNKE 1083
Query: 669 VASIMV--NGSFNDGRWHRVKAVRDGQSGKITVD 700
+ +F + R H +K R+G+ I +D
Sbjct: 1084 ETHVFTIDADNFANRRMHHLKINREGRELTIQMD 1117
Score = 60.5 bits (145), Expect = 6e-09
Identities = 78/339 (23%), Positives = 140/339 (41%), Gaps = 38/339 (11%)
Query: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS-LQFRFNC 219
SY+ F + A I+ F+ A G+ L G DF+ L I S + F +
Sbjct: 800 SYLHFPTFHAEFSA-DISFFFKTTALSGVFL----ENLGIKDFIRLEISSPSEITFAIDV 854
Query: 220 GTGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQ-SQGQYSKITFRTPL 276
G G +V ++ L WH V R+ LQ++N T + S+ + ++ + L
Sbjct: 855 GNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQL 914
Query: 277 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 336
++GG S +GF GC++SL +NG+++D+ K SG G C
Sbjct: 915 FVGGTSSR---------QKGFLGCIRSLHLNGQKMDLE--ERAKVTSGVRPG-CPGHCSS 962
Query: 337 EASCIHGGTCTAIKADSYICLCPLG-FKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQ 395
S H G K + Y+C C ++G C+ + + + S+ P+P+
Sbjct: 963 YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVS-AVFEAGTSVTYMFQEPYPVTKN 1021
Query: 396 HYLSFM-----------EFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFDC 443
LS ++F +LL+ ++ S+DF+ + L G ++ R+
Sbjct: 1022 ISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLF-INSSSQDFVVVLLCKNGSLQVRYHL 1080
Query: 444 GSGTGVLRSEDPLTLGN--WHELRVSRTAKNGILQVDKQ 480
+ + D N H L+++R + +Q+D+Q
Sbjct: 1081 NKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQ 1119
Score = 53.9 bits (128), Expect = 6e-07
Identities = 78/330 (23%), Positives = 120/330 (36%), Gaps = 52/330 (15%)
Query: 405 ITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDP-LTLGN--- 460
+ F+ GDGVL + + D +++ L G + + G L S P TLG+
Sbjct: 207 LKFKSMQGDGVLFHG-EGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLD 265
Query: 461 ---WHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 517
WH + + R K VDK +G + + ++ GG+P K + +
Sbjct: 266 DQHWHSVLIERVGKQVNFTVDKHT-QHFRTKGETDALDIDYELSFGGIPVPG--KPGTFL 322
Query: 518 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 577
K F G I+ + N GVN+ + A R + + Y
Sbjct: 323 KKNFHGCIENLYYN------------GVNIIDLAK-------------RRKHQIYT---- 353
Query: 578 LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLW 637
G C + I I G L P I +V +F+T KDGLLL
Sbjct: 354 -GNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQI------DGLSVSFQFRTWNKDGLLL- 405
Query: 638 RGDSPMRPNSDFISLGLRDGAL-VFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGK 696
+ + S + L L G L + + VA I+ + NDG WH V
Sbjct: 406 --STELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRIT 463
Query: 697 ITVDDYGARTGKSPGMMRQLNINGALYVGG 726
+T+DD A + Q+ + Y GG
Sbjct: 464 LTLDDEAAPPAPDSTWV-QIYSGNSYYFGG 492
Score = 52.0 bits (123), Expect = 2e-06
Identities = 87/433 (20%), Positives = 159/433 (36%), Gaps = 67/433 (15%)
Query: 177 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGG 236
I+L+F++ DG+L + GE + RGD ++L + + L N G A + S G
Sbjct: 205 ISLKFKSMQGDGVLFH-GEGQ--RGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLG 261
Query: 237 -------WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 289
WH+V++ R G ++ T +++G+ + L GG P
Sbjct: 262 SLLDDQHWHSVLIERVGKQVNFTVDKHTQHF-RTKGETDALDIDYELSFGGIPVPG--KP 318
Query: 290 ATGTNRGFQGCVQSLAVNG-RRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTA 348
T + F GC+++L NG ID+ + +G CS + ++
Sbjct: 319 GTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGNVTFSCSEPQIVPITFVN------ 372
Query: 349 IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFR 408
+ SY+ L P PQ + + FR
Sbjct: 373 -SSGSYLLL---------------------------------PGTPQ--IDGLSVSFQFR 396
Query: 409 PDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFD-CGSGTGVLRSEDPLTLGNWHELRVS 467
+ DG+LL + + L ++L GG + + + L G WH + ++
Sbjct: 397 TWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSIN 456
Query: 468 RTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQK 527
L +D + + + QI + GG P+ + +K F G ++
Sbjct: 457 ARRNRITLTLD-DEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRL 515
Query: 528 IILNDR---TIHVKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PL 578
I ++++ I V+ +++ + C+ C HGGSC + C+C
Sbjct: 516 IFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDT 575
Query: 579 GFEGLHCQKAIIE 591
+ G C +I E
Sbjct: 576 SYTGATCHNSIYE 588
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/132 (30%), Positives = 63/132 (47%), Gaps = 19/132 (14%)
Query: 626 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGA-LVFSYNLGSGVASIMVNGS--FNDGR 682
FKTTA G+ L DFI L + + + F+ ++G+G ++V ND +
Sbjct: 819 FKTTALSGVFLENLGI-----KDFIRLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQ 873
Query: 683 WHRVKAVRDGQSGKITVDDY--GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMR 740
WH V+A R+ + + VD+ R G R L +N L+VGG ++RQ +
Sbjct: 874 WHYVRAERNLKETSLQVDNLPRSTRETSEEGHFR-LQLNSQLFVGGT------SSRQ--K 924
Query: 741 GLVGCISHFTLS 752
G +GCI L+
Sbjct: 925 GFLGCIRSLHLN 936
Score = 43.5 bits (101), Expect = 7e-04
Identities = 40/141 (28%), Positives = 64/141 (45%), Gaps = 14/141 (9%)
Query: 594 EIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 653
++ F GRS L Y K +S + + ++FK+ DG+L + G+ D I+L
Sbjct: 179 DVADFDGRSSLLYRFNQ--KLMSTLKDVISLKFKSMQGDGVL-FHGEGQ---RGDHITLE 232
Query: 654 LRDGALVFSYNLG-------SGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGART 706
L+ G L NLG S + S + +D WH V R G+ TVD + +
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKH-TQH 291
Query: 707 GKSPGMMRQLNINGALYVGGM 727
++ G L+I+ L GG+
Sbjct: 292 FRTKGETDALDIDYELSFGGI 312
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 15/234 (6%)
Query: 145 SCSEDIVIQYPQFFGHSYVTFEPLKNSYQ--AFQITLEFRAEAEDGLLLYCGENEHGRGD 202
SCSE ++ P F +S ++ L + Q ++ +FR +DGLLL +E
Sbjct: 359 SCSEPQIV--PITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTL 416
Query: 203 FMSL--AIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPV 259
+SL I+R +Q VA I++ + + G WH+V + L L++ P
Sbjct: 417 LLSLEGGILRLVIQ---KMTERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPP 473
Query: 260 TGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLG 319
S + +I Y GG P + + FQGC++ + ++ + D+ G
Sbjct: 474 APDST--WVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQG 531
Query: 320 KA--LSGADVGECS-SGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDA 370
S + CS C C HGG+C+ Y + G C ++
Sbjct: 532 SLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHNS 585
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 86.3 bits (212), Expect = 1e-16
Identities = 94/388 (24%), Positives = 157/388 (40%), Gaps = 64/388 (16%)
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 458
S+ + + D +L Y DFL+I + G V F +D GSG G + D LT+
Sbjct: 2166 SYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTI 2224
Query: 459 GN--WHELRVSRTAKNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGV 505
+ W+ + SRT +NG + V K IV + G+T + N +F+GG+
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGL 2284
Query: 506 PNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGS 564
+KK V + F+G + + +++ I G
Sbjct: 2285 TG--KLKKADAVRVITFTGCMGETYFDNKPI---------------------------GL 2315
Query: 565 CRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFM 624
R++ DC +G + ++ QF G Y P R + S V
Sbjct: 2316 WNFREKEGDC------KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMF 2366
Query: 625 RFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWH 684
+F+T + LL++ +R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W
Sbjct: 2367 KFRTFSSSALLMYLATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWK 2423
Query: 685 RVKAVRDGQSGKITVDDYG-------ARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQ 737
R + I++ D A + L + +Y GG+ +
Sbjct: 2424 SFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEV 2483
Query: 738 YMRGLVGCISHFTLS-TDYHISLVEDAV 764
++ GC+ +S T Y+I D V
Sbjct: 2484 NLKKYSGCLKDIEISRTPYNILSSPDYV 2511
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/617 (23%), Positives = 246/617 (39%), Gaps = 117/617 (18%)
Query: 156 QFFGHSY-VTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 214
QF G Y + P++ + +FR + LL+Y + DFMS+ + ++
Sbjct: 2342 QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD--LRDFMSVELTDGHIK 2399
Query: 215 FRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPVTGQSQGQYSK 269
++ G+G+A +VS G W + L R + + N + S G
Sbjct: 2400 VSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFG 2459
Query: 270 ITFRTP--LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADV 327
+ + +Y GG P+ L R + + GC++ + I P+ +
Sbjct: 2460 LDLKADDKIYFGGLPTLRNL-RPEVNLKKYSGCLKDI-----EISRTPYNI--------- 2504
Query: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQ--FRESLRSY 385
+ + Y+ + KG E+ +T++ P+ F E
Sbjct: 2505 ---------------------LSSPDYVGVT----KGCSLENVYTVSFPKPGFVE----- 2534
Query: 386 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY------------DTGSKDFLSINLA 433
+P P++ E ++F + G++L TG ++ I L
Sbjct: 2535 -LSPVPIDVG-----TEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYV-ILLN 2587
Query: 434 GGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVEGMAE 488
G +E G+ T V+R E L G H + V RT +QVD+ ++ ++ +
Sbjct: 2588 RGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTV 2647
Query: 489 GGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVE 548
++K +F+GG P + PF G I +++N V DF V+ +
Sbjct: 2648 EQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARPVSFK 2699
Query: 549 NA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEAIEI- 595
NA AH +R AP P + P+ G C A+ I
Sbjct: 2700 NADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPALLIG 2758
Query: 596 -PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFI 650
QF + R+ + +D+ + R++ + + +T A+ GLL + ++DF
Sbjct: 2759 SKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---HADFA 2810
Query: 651 SLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSP 710
++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT SP
Sbjct: 2811 TVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISP 2869
Query: 711 GMMRQLNINGALYVGGM 727
L++ G LYVGG+
Sbjct: 2870 KKADILDVVGMLYVGGL 2886
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 62/381 (16%)
Query: 160 HSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 219
H + F+ K + I LE R EAE GLL Y H DF ++ + F ++
Sbjct: 2769 HIAIAFDDTKVKNR-LTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDL 2825
Query: 220 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 279
G+G + TKI G WH + + R G+L ++ + T S + + LY+G
Sbjct: 2826 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISPKKADILDVVGMLYVG 2884
Query: 280 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEAS 339
G P Y R GCV++L + E + + S
Sbjct: 2885 GLPINYTTRRIGPVTYSIDGCVRNL---------------------HMAEAPADLEQPTS 2923
Query: 340 CIHGGTCTA-IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 398
H GTC A + +Y F G F + F+ L
Sbjct: 2924 SFHVGTCFANAQRGTY-------FDG----TGFAKAVGGFKVGLD--------------- 2957
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP- 455
+EFE FR + GVLL + D + I + + F D G+G T V + P
Sbjct: 2958 LLVEFE--FRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPG 3014
Query: 456 -LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKN 514
L G WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3015 HLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQF 3072
Query: 515 SGVLK-PFSGSIQKIILNDRT 534
PF G I+ + L T
Sbjct: 3073 GLTTSIPFRGCIRSLKLTKGT 3093
Score = 67.0 bits (162), Expect = 6e-11
Identities = 107/507 (21%), Positives = 182/507 (35%), Gaps = 102/507 (20%)
Query: 276 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI 334
L++GGAP + F+GC+ +L +N +D RP + AD+G C+
Sbjct: 2656 LFVGGAPPEFQPSPLRNIPP-FEGCIWNLVINSVPMDFARP----VSFKNADIGRCAHQK 2710
Query: 335 CDEASCIHGGTCTA--------IKADSYICLCPLGFKG---RHCEDAFTLTIPQFRESLR 383
E G A + ++ P+ G E A + QF S
Sbjct: 2711 LREDE---DGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRN 2767
Query: 384 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 443
S+ A + + + + E+ R ++ G+L Y DF ++ L G F +D
Sbjct: 2768 SHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDL 2825
Query: 444 GSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT----- 498
GSG + G WH++++ R+ + GIL VD G + + K +
Sbjct: 2826 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVG 2879
Query: 499 DIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAP 558
+++GG+P ++ V G ++ + + + ++ +S
Sbjct: 2880 MLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSS--------------- 2924
Query: 559 CAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSG 617
H G+C F TY D K V G
Sbjct: 2925 -FHVGTC--------------------------------FANAQRGTYFDGTGFAKAVGG 2951
Query: 618 SRSN----VFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----V 669
+ V F+TT G+LL M D + + + D L+F + G+G V
Sbjct: 2952 FKVGLDLLVEFEFRTTTTTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAV 3007
Query: 670 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG--- 726
V G DG+WH+V A + ++TVD + N ++VGG
Sbjct: 3008 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3067
Query: 727 -MKEIALHTNRQYMRGLVGCISHFTLS 752
+K+ L T+ + GCI L+
Sbjct: 3068 DLKQFGLTTSIPFR----GCIRSLKLT 3090
Score = 61.6 bits (148), Expect = 3e-09
Identities = 85/411 (20%), Positives = 157/411 (38%), Gaps = 71/411 (17%)
Query: 164 TFEP--LKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT 221
T++P K SY I + + D LL Y G + DF+++ + + + F ++ G+
Sbjct: 2157 TYKPEIKKGSYN--NIVVNVKTAVADNLLFYLGSAKFI--DFLAIEMRKGKVSFLWDVGS 2212
Query: 222 GVAII-VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG 280
GV + + I W+ ++ R G NG + + G + I T +
Sbjct: 2213 GVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVR-------ALDGPKASIVPST--HHST 2263
Query: 281 APSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASC 340
+P Y ++ F G + +G +A
Sbjct: 2264 SPPGYTILDVDANAMLFVGGL------------------------------TGKLKKADA 2293
Query: 341 IHGGTCTAIKADSYICLCPLG---FKGRHCEDAFTLTIPQFRESL-------RSYAATPW 390
+ T T ++Y P+G F+ + + PQ +S YA
Sbjct: 2294 VRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSR 2353
Query: 391 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 450
P+ +S + F+ FR S +L+Y +DF+S+ L GH++ +D GSG +
Sbjct: 2354 PIRWYPNISTVMFK--FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 451 RSEDPLTLGNWHELRVSRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIG 503
S G W +SR K I+ +D ++ I + F +K + I+ G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 504 GVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 549
G+P +++ LK +SG ++ I ++ ++ T G ++EN
Sbjct: 2472 GLPTLRNLRPEVN-LKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2521
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 609 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 668
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 669 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 716
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 717 NINGALYVGGM 727
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 85.1 bits (209), Expect = 2e-16
Identities = 142/620 (22%), Positives = 246/620 (39%), Gaps = 119/620 (19%)
Query: 156 QFFGHSY-VTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ 214
QF G Y + P++ + +FR + LL+Y + DFMS+ + ++
Sbjct: 2342 QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD--LRDFMSVELTDGHIK 2399
Query: 215 FRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQL-----NNGTPVTGQSQGQYSK 269
++ G+G+A +VS G W + L R + + N + S G
Sbjct: 2400 VSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFG 2459
Query: 270 ITFRTP--LYLGGAPSAYWL---VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG 324
+ + +Y GG P+ L R + + GC++ + I P+ +
Sbjct: 2460 LDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDI-----EISRTPYNI------ 2508
Query: 325 ADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQ--FRESL 382
+ + Y+ + KG E+ +T++ P+ F E
Sbjct: 2509 ------------------------LSSPDYVGVT----KGCSLENVYTVSFPKPGFVE-- 2538
Query: 383 RSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSY------------DTGSKDFLSI 430
+P P++ E ++F + G++L TG ++ I
Sbjct: 2539 ----LSPVPIDVG-----TEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYV-I 2588
Query: 431 NLAGGHVEFRFDCGSGTG---VLRSEDPLTL-GNWHELRVSRTAKNGILQVDK-QKIVEG 485
L G +E G+ T V+R E L G H + V RT +QVD+ ++ ++
Sbjct: 2589 LLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQN 2648
Query: 486 MAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGV 545
+ ++K +F+GG P + PF G I +++N V DF V
Sbjct: 2649 LTVEQPIEVK---KLFVGGAPPEFQPSPLRNI-PPFEGCIWNLVINS----VPMDFARPV 2700
Query: 546 NVENA-----AHPCVR------APCAHGGSCRP-RKEGYDCDCPLGFEGLHCQKAIIEAI 593
+ +NA AH +R AP P + P+ G C A+
Sbjct: 2701 SFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG-PCAAESEPAL 2759
Query: 594 EI--PQF-IGRSY---LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS 647
I QF + R+ + +D+ + R++ + + +T A+ GLL + ++
Sbjct: 2760 LIGSKQFGLSRNSHIAIAFDDTKVKNRLT-----IELEVRTEAESGLLFYMARIN---HA 2811
Query: 648 DFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTG 707
DF ++ LR+G FSY+LGSG M+ NDG+WH++K +R Q G + VD RT
Sbjct: 2812 DFATVQLRNGLPYFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT- 2870
Query: 708 KSPGMMRQLNINGALYVGGM 727
SP L++ G LYVGG+
Sbjct: 2871 ISPKKADILDVVGMLYVGGL 2890
Score = 83.6 bits (205), Expect = 7e-16
Identities = 94/392 (23%), Positives = 161/392 (41%), Gaps = 68/392 (17%)
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 458
S+ + + D +L Y DFL+I + G V F +D GSG G + D LT+
Sbjct: 2166 SYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPD-LTI 2224
Query: 459 GN--WHELRVSRTAKNGILQV-----DKQKIV----EGMAEGGFT--QIKCNTDIFIGGV 505
+ W+ + SRT +NG + V K IV + G+T + N +F+GG+
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGL 2284
Query: 506 PNYDDVKKNSGV-LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGS 564
+KK V + F+G + + +++ I G
Sbjct: 2285 TG--KLKKADAVRVITFTGCMGETYFDNKPI---------------------------GL 2315
Query: 565 CRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFM 624
R++ DC +G + ++ QF G Y P R + S V
Sbjct: 2316 WNFREKEGDC------KGCTVSPQVEDSEGTIQFDGEGYALVSRPI---RWYPNISTVMF 2366
Query: 625 RFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWH 684
+F+T + LL++ +R DF+S+ L DG + SY+LGSG+AS++ N + NDG+W
Sbjct: 2367 KFRTFSSSALLMYLATRDLR---DFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWK 2423
Query: 685 RVKAVRDGQSGKITVDDYG-------ARTGKSPGMMRQLNINGALYVGG---MKEIALHT 734
R + I++ D A + L + +Y GG ++ +++
Sbjct: 2424 SFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKA 2483
Query: 735 NRQY-MRGLVGCISHFTLS-TDYHISLVEDAV 764
+ ++ GC+ +S T Y+I D V
Sbjct: 2484 RPEVNLKKYSGCLKDIEISRTPYNILSSPDYV 2515
Score = 73.9 bits (180), Expect = 5e-13
Identities = 95/381 (24%), Positives = 143/381 (37%), Gaps = 62/381 (16%)
Query: 160 HSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNC 219
H + F+ K + I LE R EAE GLL Y H DF ++ + F ++
Sbjct: 2773 HIAIAFDDTKVKNR-LTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDL 2829
Query: 220 GTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLG 279
G+G + TKI G WH + + R G+L ++ + T S + + LY+G
Sbjct: 2830 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT-ISPKKADILDVVGMLYVG 2888
Query: 280 GAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEAS 339
G P Y R GCV++L + E + + S
Sbjct: 2889 GLPINYTTRRIGPVTYSIDGCVRNL---------------------HMAEAPADLEQPTS 2927
Query: 340 CIHGGTCTA-IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYL 398
H GTC A + +Y F G F + F+ L
Sbjct: 2928 SFHVGTCFANAQRGTY-------FDG----TGFAKAVGGFKVGLD--------------- 2961
Query: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG--TGVLRSEDP- 455
+EFE FR + GVLL + D + I + + F D G+G T V + P
Sbjct: 2962 LLVEFE--FRTTTTTGVLL-GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPG 3018
Query: 456 -LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKN 514
L G WH++ ++ L VD ++ T N +F+GG P DD+K+
Sbjct: 3019 HLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFP--DDLKQF 3076
Query: 515 SGVLK-PFSGSIQKIILNDRT 534
PF G I+ + L T
Sbjct: 3077 GLTTSIPFRGCIRSLKLTKGT 3097
Score = 67.0 bits (162), Expect = 6e-11
Identities = 107/507 (21%), Positives = 182/507 (35%), Gaps = 102/507 (20%)
Query: 276 LYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLGKALSGADVGECSSGI 334
L++GGAP + F+GC+ +L +N +D RP + AD+G C+
Sbjct: 2660 LFVGGAPPEFQPSPLRNIPP-FEGCIWNLVINSVPMDFARP----VSFKNADIGRCAHQK 2714
Query: 335 CDEASCIHGGTCTA--------IKADSYICLCPLGFKG---RHCEDAFTLTIPQFRESLR 383
E G A + ++ P+ G E A + QF S
Sbjct: 2715 LREDE---DGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRN 2771
Query: 384 SYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDC 443
S+ A + + + + E+ R ++ G+L Y DF ++ L G F +D
Sbjct: 2772 SHIAIAF--DDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDL 2829
Query: 444 GSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNT----- 498
GSG + G WH++++ R+ + GIL VD G + + K +
Sbjct: 2830 GSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVD------GASNRTISPKKADILDVVG 2883
Query: 499 DIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAP 558
+++GG+P ++ V G ++ + + + ++ +S
Sbjct: 2884 MLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSS--------------- 2928
Query: 559 CAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTY-DNPDILKRVSG 617
H G+C F TY D K V G
Sbjct: 2929 -FHVGTC--------------------------------FANAQRGTYFDGTGFAKAVGG 2955
Query: 618 SRSN----VFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG----V 669
+ V F+TT G+LL M D + + + D L+F + G+G V
Sbjct: 2956 FKVGLDLLVEFEFRTTTTTGVLLGISSQKM----DGMGIEMIDEKLMFHVDNGAGRFTAV 3011
Query: 670 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG--- 726
V G DG+WH+V A + ++TVD + N ++VGG
Sbjct: 3012 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3071
Query: 727 -MKEIALHTNRQYMRGLVGCISHFTLS 752
+K+ L T+ + GCI L+
Sbjct: 3072 DLKQFGLTTSIPFR----GCIRSLKLT 3094
Score = 59.7 bits (143), Expect = 1e-08
Identities = 85/414 (20%), Positives = 157/414 (37%), Gaps = 73/414 (17%)
Query: 164 TFEP--LKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT 221
T++P K SY I + + D LL Y G + DF+++ + + + F ++ G+
Sbjct: 2157 TYKPEIKKGSYN--NIVVNVKTAVADNLLFYLGSAKFI--DFLAIEMRKGKVSFLWDVGS 2212
Query: 222 GVAII-VSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG 280
GV + + I W+ ++ R G NG + + G + I T +
Sbjct: 2213 GVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVR-------ALDGPKASIVPST--HHST 2263
Query: 281 APSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASC 340
+P Y ++ F G + +G +A
Sbjct: 2264 SPPGYTILDVDANAMLFVGGL------------------------------TGKLKKADA 2293
Query: 341 IHGGTCTAIKADSYICLCPLG---FKGRHCEDAFTLTIPQFRESL-------RSYAATPW 390
+ T T ++Y P+G F+ + + PQ +S YA
Sbjct: 2294 VRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSR 2353
Query: 391 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 450
P+ +S + F+ FR S +L+Y +DF+S+ L GH++ +D GSG +
Sbjct: 2354 PIRWYPNISTVMFK--FRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 451 RSEDPLTLGNWHELRVSRTAKN---GILQVD---KQKIVEGMAEGGF-TQIKCNTDIFIG 503
S G W +SR K I+ +D ++ I + F +K + I+ G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 504 GVPNYDDVKKNSGV---LKPFSGSIQKIILNDRTIHVKHD-----FTSGVNVEN 549
G+P ++ + LK +SG ++ I ++ ++ T G ++EN
Sbjct: 2472 GLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLEN 2525
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 18/131 (13%)
Query: 609 PDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSG 668
P+I K GS +N+ + KT D LL + G + DF+++ +R G + F +++GSG
Sbjct: 2160 PEIKK---GSYNNIVVNVKTAVADNLLFYLGSAKF---IDFLAIEMRKGKVSFLWDVGSG 2213
Query: 669 VASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYGA----------RTGKSPG-MMRQL 716
V + + + +D W+R+ A R G++G I+V + PG + +
Sbjct: 2214 VGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 717 NINGALYVGGM 727
+ N L+VGG+
Sbjct: 2274 DANAMLFVGGL 2284
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 84.3 bits (207), Expect = 4e-16
Identities = 80/303 (26%), Positives = 126/303 (41%), Gaps = 49/303 (16%)
Query: 112 PCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNS 171
PCD C + C+ CQC G GE C + + + + SY+ K
Sbjct: 1124 PCDNFDCQNGAQCI--VRINEPICQCLPGYQGEKCEKLVSVNFIN--KESYLQIPSAKVR 1179
Query: 172 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVA-IIVSET 230
Q ITL+ + + G+LLY G+ +H +++ + R ++ ++ G+ A I S
Sbjct: 1180 PQT-NITLQIATDEDSGILLYKGDKDH-----IAVELYRGRVRASYDTGSHPASAIYSVE 1233
Query: 231 KIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP---SAYWL 287
I G +H V L + L ++ G P + + S + F +PLY+GG P + L
Sbjct: 1234 TINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASL 1293
Query: 288 VRATGTN-RGFQGCVQSLAVNGRRIDMRPWPL------------------GKALSGADVG 328
+A G N F GC+++L +N D + P+ G + G
Sbjct: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG 1353
Query: 329 ---ECSSG----ICDEAS--------CIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTL 373
EC G +CD+ + C+H GTC I A SY C C G G C++ L
Sbjct: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412
Query: 374 TIP 376
P
Sbjct: 1413 FNP 1415
Score = 74.7 bits (182), Expect = 3e-13
Identities = 64/266 (24%), Positives = 117/266 (43%), Gaps = 34/266 (12%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
CD C +G C ++ + IC C G++G CE ++ L+ +A + P
Sbjct: 1125 CDNFDCQNGAQCI-VRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAK---VRP 1180
Query: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSG-TGVLRSE 453
Q ++ + D G+LLY G KD +++ L G V +D GS + S
Sbjct: 1181 QTNIT-----LQIATDEDSGILLYK---GDKDHIAVELYRGRVRASYDTGSHPASAIYSV 1232
Query: 454 DPLTLGNWHELRVSRTAKNGILQVD--KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 511
+ + GN+H + + ++ L VD KI+ +++ + + ++ +++GG+P +V
Sbjct: 1233 ETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQ--STLNFDSPLYVGGMPGKSNV 1290
Query: 512 KK------NSGVLKPFSGSIQKIILNDRTIHVKHDFTS---GVNVENAAHPCVRAPCAHG 562
+G F G I+ + +N DF + PC + CAH
Sbjct: 1291 ASLRQAPGQNGT--SFHGCIRNLYINSEL----QDFQKVPMQTGILPGCEPCHKKVCAH- 1343
Query: 563 GSCRPRKE-GYDCDCPLGFEGLHCQK 587
G+C+P + G+ C+C G+ G C +
Sbjct: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQ 1369
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/177 (28%), Positives = 82/177 (46%), Gaps = 18/177 (10%)
Query: 553 PCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGR-SYLTYDNPDI 611
PC C +G C R C C G++G C+K + FI + SYL + +
Sbjct: 1124 PCDNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSV-----NFINKESYLQIPSAKV 1178
Query: 612 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 671
+ +N+ ++ T G+LL++GD D I++ L G + SY+ GS AS
Sbjct: 1179 RPQ-----TNITLQIATDEDSGILLYKGDK------DHIAVELYRGRVRASYDTGSHPAS 1227
Query: 672 IMVN-GSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 727
+ + + NDG +H V+ + QS ++VD + + LN + LYVGGM
Sbjct: 1228 AIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGM 1284
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/46 (36%), Positives = 27/46 (58%), Gaps = 3/46 (6%)
Query: 544 GVNVENAAHPCVRAPCAHGGSCRPR---KEGYDCDCPLGFEGLHCQ 586
G + + H C+ PC HGG+C + ++G+ C C GFEG +C+
Sbjct: 951 GQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
Score = 41.2 bits (95), Expect = 0.004
Identities = 31/124 (25%), Positives = 46/124 (37%), Gaps = 15/124 (12%)
Query: 488 EGGFTQIKCNTDIFIGGVPNYDDVK------------KNSGVLKPFSGS--IQKIILNDR 533
EG F + + + IG P Y D K G+ + K++L
Sbjct: 842 EGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTP 901
Query: 534 TIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRK-EGYDCDCPLGFEGLHCQKAIIEA 592
+ VN+ +PC+ PC + G+C + Y C CP GF+G C I
Sbjct: 902 SKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHAC 961
Query: 593 IEIP 596
I P
Sbjct: 962 ISNP 965
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/136 (25%), Positives = 57/136 (41%), Gaps = 14/136 (10%)
Query: 245 DGLNGLLQLN-NGTPVTGQSQGQYSKITFRTPLYLGGAP-----SAYWL---VRATGTNR 295
DGL L L+ +G ++ +G ++ ++ + L +G P + WL V++
Sbjct: 822 DGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEP 881
Query: 296 GFQGCVQSLAVNGRRIDMRPWPLGKALSGADVG---ECSSGICDEASCIHGGTCTAIKAD 352
G C + + + P DV +C+ C C + GTC + D
Sbjct: 882 GIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNP--CLSNPCKNDGTCNSDPVD 939
Query: 353 SYICLCPLGFKGRHCE 368
Y C CP GFKG+ C+
Sbjct: 940 FYRCTCPYGFKGQDCD 955
Score = 35.4 bits (80), Expect = 0.20
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 335 CDEASCIHGGTCTAIKA--DSYICLCPLGFKGRHCE 368
C C HGGTC + D + C+C GF+G +CE
Sbjct: 961 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCE 996
Score = 35.0 bits (79), Expect = 0.27
Identities = 12/28 (42%), Positives = 15/28 (53%)
Query: 558 PCAHGGSCRPRKEGYDCDCPLGFEGLHC 585
PC H C +G+ CDC G+ G HC
Sbjct: 1046 PCQHDSKCILTPKGFKCDCTPGYVGEHC 1073
Score = 30.8 bits (68), Expect = 5.0
Identities = 12/35 (34%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCED 369
C++ C + TC ++Y CLCP + G CE+
Sbjct: 1002 CEDNDCENNSTCVD-GINNYTCLCPPEYTGELCEE 1035
>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 80.9 bits (198), Expect = 4e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 461
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1487 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1546
Query: 462 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 520
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1547 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1606
Query: 521 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 580
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1607 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1650
Query: 581 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 640
L E+ I G + + + + G L+ G
Sbjct: 1651 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1682
Query: 641 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 698
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1683 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1739
Query: 699 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 756
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1740 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1796
Query: 757 ----ISLVEDAVDGKNINTCGA 774
+LV AV +IN+C A
Sbjct: 1797 SFSKAALVSGAV---SINSCPA 1815
Score = 67.4 bits (163), Expect = 5e-11
Identities = 84/377 (22%), Positives = 146/377 (38%), Gaps = 61/377 (16%)
Query: 165 FEPLKNSYQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV 223
FE LK + A Q ++ R + G++ Y + E DFM+L + L + FN G
Sbjct: 1475 FEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEEN--DFMTLFLAHGRLVYMFNVGHKK 1532
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG-AP 282
I S+ K G WH V+ R+ +G L ++ + + + P+YLGG AP
Sbjct: 1533 LKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP 1592
Query: 283 SAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIH 342
+ F GC+ +L +NG I A V C G +
Sbjct: 1593 GKAVKNVQINSIYSFSGCLSNLQLNGASIT-------SASQTFSVTPCFEGPMET----- 1640
Query: 343 GGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFME 402
GT + + Y+ L +++F + + +
Sbjct: 1641 -GTYFSTEG-GYVVL----------DESFNIGL--------------------------K 1662
Query: 403 FEITF--RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG--SGTGVLRSEDPLTL 458
FEI F RP S G L++ + ++L++++ G V + + G + + + L
Sbjct: 1663 FEIAFEVRPRSSSGTLVHGHSVNG-EYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD 1721
Query: 459 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 518
G WH + V R + L VD + + + I +F+GGVP +
Sbjct: 1722 GRWHRITVIRDSNVVQLDVDSE-VNHVVGPLNPKPIDHREPVFVGGVPE-SLLTPRLAPS 1779
Query: 519 KPFSGSIQKIILNDRTI 535
KPF+G I+ +++ +
Sbjct: 1780 KPFTGCIRHFVIDGHPV 1796
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 612 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 671
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1478 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1534
Query: 672 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 731
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1535 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1594
Query: 732 LHTNRQY--MRGLVGCISHFTLS 752
N Q + GC+S+ L+
Sbjct: 1595 AVKNVQINSIYSFSGCLSNLQLN 1617
Score = 35.8 bits (81), Expect = 0.16
Identities = 79/346 (22%), Positives = 133/346 (38%), Gaps = 65/346 (18%)
Query: 184 EAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW----HT 239
E D +LY G +++ + ++M LAI +L + +N GT I ++K + W
Sbjct: 869 ETADQFILYLG-SKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSK-PVSSWPAYFSI 926
Query: 240 VMLYRDGLNGLLQLNNGTPVT---------GQSQGQYSKITF---RTPLYLGGAPSAYWL 287
V + R G +G + L + + G+ G S + T Y+GG PS + L
Sbjct: 927 VKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKL 986
Query: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
+ GF GC++ +N I + + K + D D+ + T
Sbjct: 987 PTSLNL-PGFVGCLELATLNNDVISLYNF---KHIYNMDPSTSVPCARDKLA------FT 1036
Query: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITF 407
+A SY F G YA + F+I
Sbjct: 1037 QSRAASYF------FDG------------------SGYAVVRDITRRGKFGQVTRFDIEV 1072
Query: 408 RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----GNWH 462
R + +G++L + GS F + + G++ +D G G + ED L +H
Sbjct: 1073 RTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYH 1130
Query: 463 ELR-VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 506
E+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1131 EISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1172
Score = 34.3 bits (77), Expect = 0.45
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 628 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 684
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 868 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 925
Query: 685 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 732
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 926 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 985
Query: 733 HTNRQYMRGLVGCISHFTLSTD 754
+ G VGC+ TL+ D
Sbjct: 986 LPTSLNLPGFVGCLELATLNND 1007
>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
Length = 1823
Score = 80.9 bits (198), Expect = 4e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 461
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1494 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1553
Query: 462 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 520
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1554 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1613
Query: 521 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 580
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1614 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1657
Query: 581 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 640
L E+ I G + + + + G L+ G
Sbjct: 1658 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1689
Query: 641 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 698
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1690 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1746
Query: 699 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 756
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1747 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1803
Query: 757 ----ISLVEDAVDGKNINTCGA 774
+LV AV +IN+C A
Sbjct: 1804 SFSKAALVSGAV---SINSCPA 1822
Score = 67.4 bits (163), Expect = 5e-11
Identities = 84/377 (22%), Positives = 146/377 (38%), Gaps = 61/377 (16%)
Query: 165 FEPLKNSYQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV 223
FE LK + A Q ++ R + G++ Y + E DFM+L + L + FN G
Sbjct: 1482 FEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEEN--DFMTLFLAHGRLVYMFNVGHKK 1539
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG-AP 282
I S+ K G WH V+ R+ +G L ++ + + + P+YLGG AP
Sbjct: 1540 LKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP 1599
Query: 283 SAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIH 342
+ F GC+ +L +NG I A V C G +
Sbjct: 1600 GKAVKNVQINSIYSFSGCLSNLQLNGASIT-------SASQTFSVTPCFEGPMET----- 1647
Query: 343 GGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFME 402
GT + + Y+ L +++F + + +
Sbjct: 1648 -GTYFSTEG-GYVVL----------DESFNIGL--------------------------K 1669
Query: 403 FEITF--RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG--SGTGVLRSEDPLTL 458
FEI F RP S G L++ + ++L++++ G V + + G + + + L
Sbjct: 1670 FEIAFEVRPRSSSGTLVHGHSVNG-EYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD 1728
Query: 459 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 518
G WH + V R + L VD + + + I +F+GGVP +
Sbjct: 1729 GRWHRITVIRDSNVVQLDVDSE-VNHVVGPLNPKPIDHREPVFVGGVPE-SLLTPRLAPS 1786
Query: 519 KPFSGSIQKIILNDRTI 535
KPF+G I+ +++ +
Sbjct: 1787 KPFTGCIRHFVIDGHPV 1803
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 612 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 671
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1485 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1541
Query: 672 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 731
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1542 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1601
Query: 732 LHTNRQY--MRGLVGCISHFTLS 752
N Q + GC+S+ L+
Sbjct: 1602 AVKNVQINSIYSFSGCLSNLQLN 1624
Score = 35.8 bits (81), Expect = 0.16
Identities = 79/346 (22%), Positives = 133/346 (38%), Gaps = 65/346 (18%)
Query: 184 EAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW----HT 239
E D +LY G +++ + ++M LAI +L + +N GT I ++K + W
Sbjct: 876 ETADQFILYLG-SKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSK-PVSSWPAYFSI 933
Query: 240 VMLYRDGLNGLLQLNNGTPVT---------GQSQGQYSKITF---RTPLYLGGAPSAYWL 287
V + R G +G + L + + G+ G S + T Y+GG PS + L
Sbjct: 934 VKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKL 993
Query: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
+ GF GC++ +N I + + K + D D+ + T
Sbjct: 994 PTSLNL-PGFVGCLELATLNNDVISLYNF---KHIYNMDPSTSVPCARDKLA------FT 1043
Query: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITF 407
+A SY F G YA + F+I
Sbjct: 1044 QSRAASYF------FDG------------------SGYAVVRDITRRGKFGQVTRFDIEV 1079
Query: 408 RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----GNWH 462
R + +G++L + GS F + + G++ +D G G + ED L +H
Sbjct: 1080 RTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYH 1137
Query: 463 ELR-VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 506
E+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1138 EISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1179
Score = 34.3 bits (77), Expect = 0.45
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 628 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 684
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 875 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 932
Query: 685 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 732
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 933 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 992
Query: 733 HTNRQYMRGLVGCISHFTLSTD 754
+ G VGC+ TL+ D
Sbjct: 993 LPTSLNLPGFVGCLELATLNND 1014
>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 80.9 bits (198), Expect = 4e-15
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 62/382 (16%)
Query: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 461
+F I R S G++ Y D DF+++ LA G + + F+ G +RS++ G W
Sbjct: 1487 QFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLW 1546
Query: 462 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK-NSGVLKP 520
H++ R +G L +D +++E K I++GGV VK +
Sbjct: 1547 HDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGKAVKNVQINSIYS 1606
Query: 521 FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGF 580
FSG + + LN G ++ +A+ PC G P + G G+
Sbjct: 1607 FSGCLSNLQLN------------GASITSASQTFSVTPCFEG----PMETGTYFSTEGGY 1650
Query: 581 EGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGD 640
L E+ I G + + + + G L+ G
Sbjct: 1651 VVLD------ESFNI---------------------GLKFEIAFEVRPRSSSGTLV-HGH 1682
Query: 641 SPMRPNSDFISLGLRDGALVFSYNLG--SGVASIMVNGSFNDGRWHRVKAVRDGQSGKIT 698
S N +++++ +++G ++ N G S+ S DGRWHR+ +RD ++
Sbjct: 1683 S---VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLD 1739
Query: 699 VDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYH-- 756
VD P + ++ ++VGG+ E L + GCI HF + D H
Sbjct: 1740 VDS-EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI--DGHPV 1796
Query: 757 ----ISLVEDAVDGKNINTCGA 774
+LV AV +IN+C A
Sbjct: 1797 SFSKAALVSGAV---SINSCPA 1815
Score = 67.4 bits (163), Expect = 5e-11
Identities = 84/377 (22%), Positives = 146/377 (38%), Gaps = 61/377 (16%)
Query: 165 FEPLKNSYQA-FQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV 223
FE LK + A Q ++ R + G++ Y + E DFM+L + L + FN G
Sbjct: 1475 FEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEEN--DFMTLFLAHGRLVYMFNVGHKK 1532
Query: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG-AP 282
I S+ K G WH V+ R+ +G L ++ + + + P+YLGG AP
Sbjct: 1533 LKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP 1592
Query: 283 SAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIH 342
+ F GC+ +L +NG I A V C G +
Sbjct: 1593 GKAVKNVQINSIYSFSGCLSNLQLNGASIT-------SASQTFSVTPCFEGPMET----- 1640
Query: 343 GGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFME 402
GT + + Y+ L +++F + + +
Sbjct: 1641 -GTYFSTEG-GYVVL----------DESFNIGL--------------------------K 1662
Query: 403 FEITF--RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG--SGTGVLRSEDPLTL 458
FEI F RP S G L++ + ++L++++ G V + + G + + + L
Sbjct: 1663 FEIAFEVRPRSSSGTLVHGHSVNG-EYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCD 1721
Query: 459 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 518
G WH + V R + L VD + + + I +F+GGVP +
Sbjct: 1722 GRWHRITVIRDSNVVQLDVDSE-VNHVVGPLNPKPIDHREPVFVGGVPE-SLLTPRLAPS 1779
Query: 519 KPFSGSIQKIILNDRTI 535
KPF+G I+ +++ +
Sbjct: 1780 KPFTGCIRHFVIDGHPV 1796
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/143 (27%), Positives = 68/143 (47%), Gaps = 5/143 (3%)
Query: 612 LKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVAS 671
LK G++S +R +T + G++ + D + +DF++L L G LV+ +N+G
Sbjct: 1478 LKGDFGAKSQFSIRLRTRSSHGMIFYVSD---QEENDFMTLFLAHGRLVYMFNVGHKKLK 1534
Query: 672 IMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIA 731
I +NDG WH V +R+ SG++ +D P I G +Y+GG+
Sbjct: 1535 IRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAPGK 1594
Query: 732 LHTNRQY--MRGLVGCISHFTLS 752
N Q + GC+S+ L+
Sbjct: 1595 AVKNVQINSIYSFSGCLSNLQLN 1617
Score = 35.8 bits (81), Expect = 0.16
Identities = 79/346 (22%), Positives = 133/346 (38%), Gaps = 65/346 (18%)
Query: 184 EAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW----HT 239
E D +LY G +++ + ++M LAI +L + +N GT I ++K + W
Sbjct: 869 ETADQFILYLG-SKNAKKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSK-PVSSWPAYFSI 926
Query: 240 VMLYRDGLNGLLQLNNGTPVT---------GQSQGQYSKITF---RTPLYLGGAPSAYWL 287
V + R G +G + L + + G+ G S + T Y+GG PS + L
Sbjct: 927 VKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKL 986
Query: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
+ GF GC++ +N I + + K + D D+ + T
Sbjct: 987 PTSLNL-PGFVGCLELATLNNDVISLYNF---KHIYNMDPSTSVPCARDKLA------FT 1036
Query: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITF 407
+A SY F G YA + F+I
Sbjct: 1037 QSRAASYF------FDG------------------SGYAVVRDITRRGKFGQVTRFDIEV 1072
Query: 408 RPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL-----GNWH 462
R + +G++L + GS F + + G++ +D G G + ED L +H
Sbjct: 1073 RTPADNGLILLMVN-GSM-FFRLEMRNGYLHVFYDFGFSGGPVHLEDTLKKAQINDAKYH 1130
Query: 463 ELR-VSRTAKNGILQVDKQKIVEGMAEGGFTQIKCN-TDIFIGGVP 506
E+ + K IL VD++ + E ++K TDI+IGG P
Sbjct: 1131 EISIIYHNDKKMILVVDRRHVKSMDNE----KMKIPFTDIYIGGAP 1172
Score = 34.3 bits (77), Expect = 0.45
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 17/142 (11%)
Query: 628 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG---SFNDGRWH 684
T D +L+ G + +++ L +++ LV+ YNLG+ I ++ S +
Sbjct: 868 TETADQFILYLGSKNAK--KEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFS 925
Query: 685 RVKAVRDGQSGKI---------TVDDYGARTGKSPGMMRQLNI---NGALYVGGMKEIAL 732
VK R G+ GK+ T ++ + G+ G L++ + YVGG+
Sbjct: 926 IVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFK 985
Query: 733 HTNRQYMRGLVGCISHFTLSTD 754
+ G VGC+ TL+ D
Sbjct: 986 LPTSLNLPGFVGCLELATLNND 1007
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 78.6 bits (192), Expect = 2e-14
Identities = 100/384 (26%), Positives = 154/384 (40%), Gaps = 50/384 (13%)
Query: 397 YLSFMEF--EIT------FRPDSGDGVLLYSYDTGSKDFLSINL-AGGHVEFRFDCGSGT 447
YL F F E+T F+ GV + + G DF+ I L A V F FD G+G
Sbjct: 803 YLHFPAFHGELTADVCFFFKTTVSSGVFMENL--GITDFIRIELRAPTEVTFSFDVGNGP 860
Query: 448 G--VLRSEDPLTLGNWHELRVSRTAKNGILQVDK--QKIVEGMAEGGFTQIKCNTDIFIG 503
++S P WH +R R K LQVD+ QK+ A+G +++ N+ +FIG
Sbjct: 861 CEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADG-HVRLQLNSQLFIG 919
Query: 504 GVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNVENAAHPCVRAP-CA 560
G + F G I+ + LN + ++ T GV A H C
Sbjct: 920 GTATRQ---------RGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCR 970
Query: 561 HGGSCRPRKEGYDCDCPL-GFEGLHCQKAI----IEAIEIPQFIGRSYLTYDNPDIL--- 612
+GG CR ++ G CDC ++G C I + Y +N L
Sbjct: 971 NGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSS 1030
Query: 613 --KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGV 669
+ V+ +R + + F+TT LLL+ +++S+ L +G+L Y L
Sbjct: 1031 LYRDVTLTREMITLSFRTTRSPSLLLYVSSF----YEEYLSVILANNGSLQIRYKLDRHQ 1086
Query: 670 ASIMVNGSFN---DGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 726
F DG+ H+VK R+ + V+ A+ + N +L +G
Sbjct: 1087 NPDAFTFDFKNMADGQLHQVKINREEAVVMVEVNQ-SAKKQVILSSGTEFNAVKSLILGK 1145
Query: 727 MKEIA---LHTNRQYMRGLVGCIS 747
+ E A T R G GC+S
Sbjct: 1146 VLEAAGADPDTRRAATSGFTGCLS 1169
Score = 49.3 bits (116), Expect = 1e-05
Identities = 95/433 (21%), Positives = 157/433 (36%), Gaps = 69/433 (15%)
Query: 177 ITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTG-VAIIVSETKIKLG 235
I+L+F+A +G+LL+ E +HG + ++L +I+ L F N G + ++ + LG
Sbjct: 208 ISLKFKAMQSNGILLH-REGQHG--NHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTLG 264
Query: 236 G------WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVR 289
WH+V++ ++ T Q++G S + + GG S R
Sbjct: 265 SLLDDQHWHSVLIELLDTQVNFTVDKHTHHF-QAKGDSSNLDLNFEISFGGILSP-GRSR 322
Query: 290 ATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAI 349
A T + F GC+++L NG DV E + H +
Sbjct: 323 AF-TRKSFHGCLENLYYNG----------------VDVTELAKK--------HKPQILMM 357
Query: 350 KADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPL-EPQHYLSFMEFEITFR 408
S+ C P T+P S RSY A P E + ++F FR
Sbjct: 358 GNVSFSCPQPQ-------------TVPVTFLSSRSYLALPGNSGEDKVSVTFQ-----FR 399
Query: 409 PDSGDGVLLYS-YDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVS 467
+ G LL+ GS F+ G F G + + L G WH + S
Sbjct: 400 TWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQWHSVSFS 459
Query: 468 RTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQK 527
+ + VD V+ + I + GG L F G ++
Sbjct: 460 AKWSHMNVVVDDDTAVQPLVA---VLIDSGDTYYFGGCLGNSSGSGCKSPLGGFQGCLRL 516
Query: 528 IILNDRTIH---VKHDFTSG-----VNVENAAHPCVRAPCAHGGSCRPRKEGYDCDC-PL 578
I + D+ + V+ ++ C+ + C HGG C + + CDC
Sbjct: 517 ITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGT 576
Query: 579 GFEGLHCQKAIIE 591
G+ G C ++ E
Sbjct: 577 GYTGETCHSSLYE 589
Score = 37.4 bits (85), Expect = 0.053
Identities = 80/383 (20%), Positives = 135/383 (35%), Gaps = 63/383 (16%)
Query: 380 ESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEF 439
+S Y PL+P + + F+ +G+LL+ + + +++ L G + F
Sbjct: 189 QSALLYTLDKKPLKPIRDV----ISLKFKAMQSNGILLHR-EGQHGNHITLELIKGKLVF 243
Query: 440 RFDCGSGTGVLRSEDP---LTLGN------WHELRVSRTAKNGILQVDKQKIVEGMAEGG 490
+ SG L S LTLG+ WH + + VDK A+G
Sbjct: 244 FLN--SGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGD 300
Query: 491 FTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENA 550
+ + N +I GG+ + + K F G ++ + N GV+V
Sbjct: 301 SSNLDLNFEISFGGI--LSPGRSRAFTRKSFHGCLENLYYN------------GVDVTEL 346
Query: 551 AHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPD 610
A G + C P + + + RSYL
Sbjct: 347 AKKHKPQILMMGNV------SFSCPQP-------------QTVPVTFLSSRSYLALPGNS 387
Query: 611 ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFS-YNLGSGV 669
+VS V +F+T + G LL+ ++ S L L+DG L S + G
Sbjct: 388 GEDKVS-----VTFQFRTWNRAGHLLF---GELQRGSGSFVLFLKDGKLKLSLFQAGQSP 439
Query: 670 ASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
++ NDG+WH V + VDD T P + ++ Y GG
Sbjct: 440 RNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDD---DTAVQPLVAVLIDSGDTYYFGGCLG 496
Query: 730 IALHTN-RQYMRGLVGCISHFTL 751
+ + + + G GC+ T+
Sbjct: 497 NSSGSGCKSPLGGFQGCLRLITI 519
Score = 36.2 bits (82), Expect = 0.12
Identities = 40/166 (24%), Positives = 62/166 (37%), Gaps = 30/166 (18%)
Query: 215 FRFNCGTGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNN------GTPVTGQSQGQ 266
F F+ G G + S T WH V R+ LQ++ P G
Sbjct: 852 FSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADG----- 906
Query: 267 YSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGAD 326
+ ++ + L++GG + RGF GC++SL +NG +D+ +A
Sbjct: 907 HVRLQLNSQLFIGGTATR---------QRGFLGCIRSLQLNGVALDLEE----RATVTPG 953
Query: 327 VGECSSGICDEAS--CIHGGTCTAIKADSYICLCPL-GFKGRHCED 369
V +G C C +GG C K C C + G C +
Sbjct: 954 VEPGCAGHCSTYGHLCRNGGRCRE-KRRGVTCDCAFSAYDGPFCSN 998
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,730,374
Number of Sequences: 37866
Number of extensions: 1576521
Number of successful extensions: 6143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 3911
Number of HSP's gapped (non-prelim): 1889
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.