Guide to the Human Genome
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Search of human proteins with 33356550

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33356550 G patch domain containing 4 isoform 2 [Homo
sapiens]
         (370 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33356550 G patch domain containing 4 isoform 2 [Homo sapiens]      751   0.0  
gi|33356552 G patch domain containing 4 isoform 1 [Homo sapiens]      741   0.0  
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    64   3e-10
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            62   1e-09
gi|148747556 PIN2-interacting protein 1 [Homo sapiens]                 61   2e-09
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            60   3e-09
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    55   1e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    54   2e-07
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    54   3e-07
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    53   5e-07
gi|148746195 trichohyalin [Homo sapiens]                               53   5e-07
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     52   7e-07
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    52   7e-07
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    52   7e-07
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    52   7e-07
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    52   7e-07
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ...    52   9e-07
gi|50962882 G patch domain containing 8 [Homo sapiens]                 51   1e-06
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ...    49   7e-06
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]            49   7e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    49   7e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    49   7e-06
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    49   9e-06
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                48   2e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   2e-05
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    47   2e-05
gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]      47   2e-05
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    47   4e-05
gi|33356179 transcription termination factor, RNA polymerase I [...    47   4e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       47   4e-05

>gi|33356550 G patch domain containing 4 isoform 2 [Homo sapiens]
          Length = 370

 Score =  751 bits (1940), Expect = 0.0
 Identities = 370/370 (100%), Positives = 370/370 (100%)

Query: 1   MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEF 60
           MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEF
Sbjct: 1   MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEF 60

Query: 61  TNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGE 120
           TNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGE
Sbjct: 61  TNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGE 120

Query: 121 KPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQA 180
           KPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQA
Sbjct: 121 KPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQA 180

Query: 181 FLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKS 240
           FLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKS
Sbjct: 181 FLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKS 240

Query: 241 KKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEE 300
           KKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEE
Sbjct: 241 KKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEE 300

Query: 301 EKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWW 360
           EKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWW
Sbjct: 301 EKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWW 360

Query: 361 NQGSREQSMQ 370
           NQGSREQSMQ
Sbjct: 361 NQGSREQSMQ 370


>gi|33356552 G patch domain containing 4 isoform 1 [Homo sapiens]
          Length = 375

 Score =  741 bits (1913), Expect = 0.0
 Identities = 365/365 (100%), Positives = 365/365 (100%)

Query: 6   EVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWW 65
           EVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWW
Sbjct: 11  EVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWW 70

Query: 66  NELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKD 125
           NELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKD
Sbjct: 71  NELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKD 130

Query: 126 LESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARL 185
           LESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARL
Sbjct: 131 LESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARL 190

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
           KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR
Sbjct: 191 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 250

Query: 246 RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
           RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV
Sbjct: 251 RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 310

Query: 306 LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSR 365
           LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSR
Sbjct: 311 LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSR 370

Query: 366 EQSMQ 370
           EQSMQ
Sbjct: 371 EQSMQ 375


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 74/348 (21%), Positives = 140/348 (40%), Gaps = 32/348 (9%)

Query: 33   KENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSK 92
            K + + + +  T+K+D+     D        +    F K   + + +  +         K
Sbjct: 869  KSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK-------RK 921

Query: 93   ETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQAC 152
            E T  +   P  L +K  K       G      LESC +  +  +K  +   +E+    C
Sbjct: 922  EQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGC 981

Query: 153  EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
            E     K+   G   K     LE  E+   AR K +  G  + + E   P++ K+K   K
Sbjct: 982  ESGFKDKSD--GDFGKG----LEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDK 1035

Query: 213  EEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTS 272
            ++ E +  E+   D++  +  ++  +K  K+K +   GK  + +    +G EK++ A   
Sbjct: 1036 DKSEKSILEKCQKDKEFDKCFKE--KKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPG 1093

Query: 273  GLGELNSREQTNQSLRKGKKKKRWH--------HEEEKMGVLEEGGKGKEAAGSVRTEEV 324
             + E  S ++ +   +KGK+K  W+         E+++   +  G K  EA+   RT+ +
Sbjct: 1094 IISEDFSEKKDD---KKGKEKS-WYIADIFTDESEDDRDSCMGSGFKMGEASDLPRTDGL 1149

Query: 325  ESR-----AYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
            + +     AYA    R+   +Q  E   + E R     R      R++
Sbjct: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDK 1197



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 4/142 (2%)

Query: 210  RQKEE-EEATASERN--DADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKE 266
            ++KEE  EA AS+R+   +D++HPE  +    + ++K R   +     + +   K  EK+
Sbjct: 1150 QEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKK 1209

Query: 267  DAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVES 326
            D   T    +   R   + +  K K K++   + EK    E+  K K    S +    E 
Sbjct: 1210 DKESTEKYKDRKDRASVDSTQDK-KNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKER 1268

Query: 327  RAYADPCSRRKKRQQQEEEDLN 348
            ++     + +   ++ EEE L+
Sbjct: 1269 KSSRSADAEKSLLEKLEEEALH 1290



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 53/261 (20%), Positives = 97/261 (37%), Gaps = 53/261 (20%)

Query: 59  EFTNHW------------WNE---LFNKTAANLVVET--GQDGVQIRSLSKETTRYNHPK 101
           + T HW            W+E   L + T   L  E+    +G  + SL     R  H K
Sbjct: 541 QHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRK 600

Query: 102 PNLLYQKFVKMATLTSGG------------------EKPNKDLESCS------------D 131
              L +K     +   G                   +  NK+   CS            +
Sbjct: 601 RASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYE 660

Query: 132 DDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPG 191
            ++   KS K +  E  L         K  R     + KL++++ +E+ +L + +     
Sbjct: 661 YEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKR 720

Query: 192 APQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSK------KKKR 245
                 +     +++K R  K E+E +  E++  +EK   + E+  +KSK      +KK 
Sbjct: 721 IKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKN 780

Query: 246 RHQEGKVSDEREGTTKGNEKE 266
             +E K+S E+E   K ++++
Sbjct: 781 DLKEDKISKEKEKIFKEDKEK 801



 Score = 35.4 bits (80), Expect = 0.083
 Identities = 67/329 (20%), Positives = 126/329 (38%), Gaps = 47/329 (14%)

Query: 81   GQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKP-----------NKDLESC 129
            G+D  +  SL +   +     P ++ + F +      G EK              D +SC
Sbjct: 1071 GKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSC 1130

Query: 130  SDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQD 189
                 +  ++  +   + L +  EGR A+ + R     K+   +   +++    R + +D
Sbjct: 1131 MGSGFKMGEASDLPRTDGLQEKEEGREAYASDR---HRKSSDKQHPERQKDKEPRDRRKD 1187

Query: 190  PGAPQLQSESKPP---KKKKKKRRQKEEEEATASERNDAD--------EKHPEHAEQNIR 238
             GA     + K     K K+KK ++  E+     +R   D        +K PE AE+   
Sbjct: 1188 RGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHA 1247

Query: 239  KSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNS------REQTNQSLRKGKK 292
               K K +H+E   SD+     + + +   A  S L +L        RE +N  + +   
Sbjct: 1248 AEDKAKSKHKE--KSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSS 1305

Query: 293  KKRWHHEEE-------KMGVLEEGGKGKEAAGSVRTEEV-ESRAYADPCSRRKK---RQQ 341
                   +E       ++   E  G  K    +   E++ E   +    S  KK   R++
Sbjct: 1306 DSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRER 1365

Query: 342  QEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
             ++E    +++GE+   +   GSR+ S Q
Sbjct: 1366 AKKEKAEKKEKGED---YKEGGSRKDSGQ 1391



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 15/61 (24%)

Query: 228 KHPEHAEQNIRKSKKKKRRHQE--------GKVSD-------EREGTTKGNEKEDAAGTS 272
           + P +A+Q   K+K KK+R +E        GK SD       E E +  G +  D+ G+S
Sbjct: 440 REPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSS 499

Query: 273 G 273
           G
Sbjct: 500 G 500



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 19/71 (26%), Positives = 34/71 (47%)

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
           K +   A + +S  +   K++K R  KEE +  + +R    EK  +  E  I K K+K  
Sbjct: 736 KDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIF 795

Query: 246 RHQEGKVSDER 256
           +  + K+  E+
Sbjct: 796 KEDKEKLKKEK 806



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 2/83 (2%)

Query: 185 LKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKK 244
           LK + P   +L+   +  KKK K R  K E++    E  D   K  E   +  ++  KK+
Sbjct: 748 LKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKE--DKISKEKEKIFKEDKEKLKKE 805

Query: 245 RRHQEGKVSDEREGTTKGNEKED 267
           + ++E    DE     +  E ED
Sbjct: 806 KVYREDSAFDEYCNKNQFLENED 828



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 36/182 (19%), Positives = 75/182 (41%), Gaps = 9/182 (4%)

Query: 180  AFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRK 239
            AFL     + PG  + +  +  P+K K+K R +    +++ + +D +    E AE+    
Sbjct: 1319 AFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSS-SSSKKSHDRERAKKEKAEK---- 1373

Query: 240  SKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLR---KGKKKKRW 296
             K+K   ++EG    +     K   + DA G S   + +  ++ ++++      KK K  
Sbjct: 1374 -KEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKND 1432

Query: 297  HHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEET 356
               E    + +E      +A ++  E+ +   + +     K+R +    D  L    +E 
Sbjct: 1433 SEREPSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDEL 1492

Query: 357  FR 358
             R
Sbjct: 1493 LR 1494


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 43/189 (22%), Positives = 86/189 (45%), Gaps = 17/189 (8%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           + E +  +KK+++ R+K + E     + +  +K  +   +   + +KK+RR +E K  +E
Sbjct: 52  KKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEE 111

Query: 256 REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEK------------M 303
           +E   K  +KE    +    E   +E+  +  RK +++K+   E+E+            +
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQV 171

Query: 304 GVLEEGGKGKEAAGSV-----RTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
           G  EE  K KE          R E  + R   +   R+K+R+++EE     +   +  +R
Sbjct: 172 GEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWR 231

Query: 359 WWNQGSREQ 367
              +G RE+
Sbjct: 232 EKERGKRER 240



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 12/180 (6%)

Query: 193 PQLQSESKPPKKKKKKRRQ--KEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEG 250
           P  QSE +  +++ + R++  KE E     ER + +++  E  ++  R+  KK+++ +  
Sbjct: 32  PGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERK 91

Query: 251 KVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGG 310
           K  +ERE   +  EKE+       GE   + +  +   +G+  K     E K     E  
Sbjct: 92  K--EERERKKRRREKENKE-----GEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144

Query: 311 KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
           K +E     R +E E +   +   R +K+  ++EE+   ++R E   R  N+  R++  +
Sbjct: 145 KERERKKEEREKERERK---ERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 37/161 (22%), Positives = 71/161 (44%), Gaps = 8/161 (4%)

Query: 168 KAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKE------EEEATASE 221
           K K    + +E+    R + ++    + + + K  +KK++ R  KE      +EE    E
Sbjct: 84  KEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREE 143

Query: 222 RNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSRE 281
           R + + K  E  ++  RK +KK+ R Q G+  +ER+   +   K+             RE
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK--ERKKERE 201

Query: 282 QTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTE 322
           +  +  RK ++KK+   ++E+    +   + KE     R E
Sbjct: 202 RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 42/212 (19%), Positives = 87/212 (41%), Gaps = 34/212 (16%)

Query: 153 EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
           EG+   ++ R     + +  + E +++    R K +  G        K  +++KK+RR+K
Sbjct: 50  EGKKERESERKKERREREKRKREREKERKRERGKKEKKG-----ERKKEERERKKRRREK 104

Query: 213 EEEEATASERNDADEKHPE----------HAEQNIRKSKKKKRRHQEGKVSDEREGTTKG 262
           E +E    E+    EK               ++  ++ ++K+R  ++ +   ERE   + 
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK 164

Query: 263 NEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTE 322
             +    G          E+  +  RK +KK+  + +E K          KE     R E
Sbjct: 165 KRERKQVG-------EKEEERKEKERKERKKRERNRKERK----------KERERKERRE 207

Query: 323 EVESRAYADPCSRRKKRQQQEEEDLNLEDRGE 354
             + R   +   R+K+RQ+  + +   ++RG+
Sbjct: 208 RKKERKKKE--ERKKERQKDRQTNWREKERGK 237


>gi|148747556 PIN2-interacting protein 1 [Homo sapiens]
          Length = 328

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 70/244 (28%), Positives = 103/244 (42%), Gaps = 19/244 (7%)

Query: 13  KFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKT 72
           KF +  L K GW++GKGLG +E G T  ++V +K +  G+G     E       + FN+ 
Sbjct: 28  KFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQL 87

Query: 73  AANLVVETGQ------DGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDL 126
            A L    GQ      D  + +S S E  +    K  + Y KF K   L+S   +   DL
Sbjct: 88  LAELNTCHGQETTDSSDKKEKKSFSLE-EKSKISKNRVHYMKFTKGKDLSS---RSKTDL 143

Query: 127 ESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLA-RLEAQEQAFLARL 185
           + C     Q  K+P+   D       E  T   +A    T++   A R+ A +      +
Sbjct: 144 D-CIFGKRQSKKTPE--GDASPSTPEENETTTTSA---FTIQEYFAKRMAALKNKPQVPV 197

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
            G D    + Q E K  KK+ K+   K+ E     +     E  PE AE   R +KKK  
Sbjct: 198 PGSD--ISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSA 255

Query: 246 RHQE 249
             +E
Sbjct: 256 PAEE 259


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 18/160 (11%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           +   K  KKK+KKR + +E E    ER    ++  E   +  +K KKK+ R Q G+    
Sbjct: 56  RERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR---- 111

Query: 256 REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE-EGGKGKE 314
           RE   K   KE             RE+ N+  R+ K+KKR   +  K    E E GK + 
Sbjct: 112 RERKKKKERKE-------------RERENKQRRERKRKKRRKKKRRKERKREKERGKRER 158

Query: 315 AAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGE 354
                + EE E +   +   R+K+R+++E  +   E + E
Sbjct: 159 KRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 12/163 (7%)

Query: 197 SESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDER 256
           S    P  +++  R+KE  E    +R    E+  E   +  +K KKK+++ + GK   ER
Sbjct: 23  SHISKPCTQRESERKKERREREKRKR----EREKERKRERGKKEKKKRKKRERGK---ER 75

Query: 257 EGTTKGNEKE-----DAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGK 311
           E   K  EK+     +        E   RE+  +  R+ KKKK     E +     E  +
Sbjct: 76  ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135

Query: 312 GKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGE 354
            K      R E    +       +RKKR+++E E     +R E
Sbjct: 136 KKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKE 178



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 34/150 (22%), Positives = 68/150 (45%), Gaps = 2/150 (1%)

Query: 155 RTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEE 214
           R   +    G   K K  + E  ++    R + +     + + E +  KK+KKKR +K+ 
Sbjct: 50  REKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQR 109

Query: 215 EEATASERNDADEKHPEHAEQNIRKSKK--KKRRHQEGKVSDEREGTTKGNEKEDAAGTS 272
                 ++ +  E+  E+ ++  RK KK  KK+R +E K   ER    +  +K       
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEERE 169

Query: 273 GLGELNSREQTNQSLRKGKKKKRWHHEEEK 302
              E N +E+  +  RK +++++   ++E+
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKER 199



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 10/162 (6%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDAD-EKHPEHAEQNIRKSKK 242
           R +G+     + + E    +++K+K R+K+ +E    ER     EK     +Q  R+ +K
Sbjct: 56  RERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERK 115

Query: 243 KKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEK 302
           KK+  +E     ERE   +   K          +   RE+  +  R+ K+KKR   E EK
Sbjct: 116 KKKERKE----RERENKQRRERKRKKRRKKKRRKERKREK-ERGKRERKRKKRKKEEREK 170

Query: 303 MGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEE 344
                   + KE     R E  + R       RRKK++++++
Sbjct: 171 KRERNRKERKKERERKERRERKKERKK----ERRKKKERKKD 208



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 30/135 (22%), Positives = 60/135 (44%), Gaps = 18/135 (13%)

Query: 173 RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEK---- 228
           R E +E+    R K +     + +   +  KKK++K R++E ++    +R    +K    
Sbjct: 86  RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK 145

Query: 229 -HPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSL 287
                 E+  R+ K+KKR+ +E +   ER    +  E+E             R++  +  
Sbjct: 146 ERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERE-------------RKERRERK 192

Query: 288 RKGKKKKRWHHEEEK 302
           ++ KK++R   E +K
Sbjct: 193 KERKKERRKKKERKK 207



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 3/130 (2%)

Query: 238 RKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWH 297
           R+S++KK R +  K   ERE   K  ++E         +   R +  +  RK ++K+R  
Sbjct: 32  RESERKKERREREKRKRERE---KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKE 88

Query: 298 HEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETF 357
             E++    ++  K +E     R E  + +   +     K+R++++ +    + R +E  
Sbjct: 89  RREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148

Query: 358 RWWNQGSREQ 367
           R   +G RE+
Sbjct: 149 REKERGKRER 158



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 18/61 (29%), Positives = 37/61 (60%), Gaps = 1/61 (1%)

Query: 198 ESKPPKKKKKKRRQKEEEEATASERNDAD-EKHPEHAEQNIRKSKKKKRRHQEGKVSDER 256
           E +  K+++K++++K+EE     ERN  + +K  E  E+  RK ++KK R ++ +   +R
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209

Query: 257 E 257
           +
Sbjct: 210 K 210



 Score = 33.5 bits (75), Expect = 0.31
 Identities = 12/54 (22%), Positives = 30/54 (55%)

Query: 203 KKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDER 256
           KK+KK+ R+K+ E      + + + K     ++  +K ++KK+  ++ + +D +
Sbjct: 161 KKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214



 Score = 32.7 bits (73), Expect = 0.54
 Identities = 14/72 (19%), Positives = 37/72 (51%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           R + ++ G  + + + +  ++++KKR +  +E     ER +  E+  E  ++  +K ++K
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERK 206

Query: 244 KRRHQEGKVSDE 255
           K R  + +   +
Sbjct: 207 KDRKTDRQTDSQ 218



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 15/74 (20%), Positives = 40/74 (54%), Gaps = 1/74 (1%)

Query: 196 QSESKPPKKK-KKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSD 254
           + E K  K++ K++R++K+ ++    ++ + + K  +   +   + ++KK R +E +   
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203

Query: 255 EREGTTKGNEKEDA 268
           ER+   K + + D+
Sbjct: 204 ERKKDRKTDRQTDS 217


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 49/154 (31%), Positives = 74/154 (48%), Gaps = 34/154 (22%)

Query: 203 KKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKG 262
           KKKKKK+++ EE E T       +E   E  ++  RK K+K++R ++ K    +E T K 
Sbjct: 1   KKKKKKKKETEETEET-------EETEEEEEKEGKRKEKRKEKRKEKEKKKKTKE-TEKR 52

Query: 263 NEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTE 322
            EKE              E+  +  RK KKKK    EEE+    EE  + KE       E
Sbjct: 53  KEKE--------------EEEKKRKRKRKKKKE---EEEREEEEEEEEEEKE-----EEE 90

Query: 323 EVESRAYADPCSRRKKRQQQEEEDLNLEDRGEET 356
           + E R       ++KKR+++EEE+   + R  +T
Sbjct: 91  KEEGRRR----KKKKKRRRKEEEEEKKKKRRRKT 120



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 24/70 (34%), Positives = 42/70 (60%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           + E +  K+K+K++++KEEEE    E  + +EK  E  E+  R+ KKKKRR +E +   +
Sbjct: 54  EKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKK 113

Query: 256 REGTTKGNEK 265
           ++   K  +K
Sbjct: 114 KKRRRKTKKK 123



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 29/109 (26%), Positives = 57/109 (52%), Gaps = 16/109 (14%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
           + + E +   K+K+KR++K +E+    +  + +++  +  E+  RK K+KK++ +E +  
Sbjct: 18  ETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREE 77

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEK 302
           +E E   +  EKE+             E+  +  R+ KKKKR   EEE+
Sbjct: 78  EEEE---EEEEKEE-------------EEKEEGRRRKKKKKRRRKEEEE 110


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 11/185 (5%)

Query: 186  KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
            +G+  G  + + E K  ++ ++   + EEEE      +   E   E  E    + + +  
Sbjct: 907  EGEGEGEEE-EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE 965

Query: 246  RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
              +EG+   E EG  +G E+E      G GE    E+  +   +G+++     EEE+ G 
Sbjct: 966  GEEEGEGEGE-EGEGEGEEEEG----EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020

Query: 306  LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSR 365
            +E   +G+E  G    EE E          R+K  + EE   N E+  EE  ++   G  
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEG-----EEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075

Query: 366  EQSMQ 370
            E   Q
Sbjct: 1076 ENERQ 1080



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 43/171 (25%), Positives = 78/171 (45%), Gaps = 8/171 (4%)

Query: 191 GAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEK--HPEHAEQNIRKSKKKKRRHQ 248
           G  +L  + +  K+  +++ QKE E+    ERN   E+    EH E    +  +++   +
Sbjct: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751

Query: 249 EGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQS---LRKGKKKK-RWHHEEEKMG 304
           EG+  +E EG     E+E   G     E   +E+  +      +G++++     EE++ G
Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEG 811

Query: 305 VLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
              EGG+ +E  G    EE E     +     ++  + EEE+   E +GEE
Sbjct: 812 GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE--GEGKGEE 860



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 20/169 (11%)

Query: 190 PGAPQLQSESKPPKKKKKKR--RQKEEEEATASERNDADEK--HPEHAEQNIRKSKKKKR 245
           PG  + +   K   KK+      QKE E+    ERN   E+    EH E    +  +++ 
Sbjct: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748

Query: 246 RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
             +EG+  +E EG     E+E        GE    E+  +  +  ++  +   EEE+   
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEE-----GERKKEERAGKEEKGEEEGDQGEGEEEE--- 800

Query: 306 LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGE 354
            E  G+ KE  G V   EVE          + +R+++EEE    E+ GE
Sbjct: 801 TEGRGEEKEEGGEVEGGEVE--------EGKGEREEEEEEGEGEEEEGE 841



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 40/169 (23%), Positives = 71/169 (42%), Gaps = 10/169 (5%)

Query: 187 GQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRR 246
           G++      + E    ++++K+   KEE E    E     E+     E+   K +K +  
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790

Query: 247 HQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVL 306
             +G+  +E E   +G EKE+       GE+   E       + ++++    EEE+    
Sbjct: 791 GDQGE-GEEEETEGRGEEKEEG------GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843

Query: 307 EEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
           EE G+G+E  G  + EE       +      + + +EEE    E  GEE
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEG---EGEGEE 889



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 42/183 (22%), Positives = 79/183 (43%), Gaps = 11/183 (6%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHA-EQNIRKSKKKKRRHQEGKVS- 253
           + E    ++++  R ++EE+E    E  + +E   E   E+  RK +++  + ++G+   
Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791

Query: 254 -----DEREGTTKGNEKEDAAGTSG--LGELNSREQTNQSLRKGKKKKRWHHEEEKMGVL 306
                +E E   +G EKE+     G  + E     +  +   +G++++    EEE  G  
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851

Query: 307 EEG-GKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEE-EDLNLEDRGEETFRWWNQGS 364
           EEG GKG+E       EE       +      + + +EE E    E+ GE       +G 
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911

Query: 365 REQ 367
            E+
Sbjct: 912 GEE 914



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 44/186 (23%), Positives = 71/186 (38%), Gaps = 26/186 (13%)

Query: 207  KKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR-----------------RHQE 249
            K  R++EEEE    E     E+     E+   + K ++                    +E
Sbjct: 823  KGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882

Query: 250  GKVSDEREGTTKGNEK--EDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
            G+   E EG  +G E+  E      G GE    E   +   +G++ +    EEE  G  E
Sbjct: 883  GEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE 942

Query: 308  EG-GKGKEAAGSVRTEEVESRAYADPCSRRK------KRQQQEEEDLNLEDRGEETFRWW 360
            +G G+G+E  G    EE E     +     +      + +++E E    E+ GEE     
Sbjct: 943  DGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002

Query: 361  NQGSRE 366
             +G  E
Sbjct: 1003 GEGEEE 1008



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 5/163 (3%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPE-HAEQNIRKSKKKKRRHQEGKVSD 254
           + E +  ++KK++R  KEE+     ++ + +E+  E   E+     + +    +EGK   
Sbjct: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826

Query: 255 EREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV-LEEGGKGK 313
           E E      E+E+  G    GE    E   +   +G++ +     EE  G   EE G+G+
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886

Query: 314 -EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
            E  G    EE E     +     +   ++EE +   E+ GEE
Sbjct: 887 GEEEGEGEGEEEEGEGEGE--EEGEGEGEEEEGEGKGEEEGEE 927



 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 43/186 (23%), Positives = 78/186 (41%), Gaps = 14/186 (7%)

Query: 186 KGQDPG----APQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSK 241
           KG++ G      + ++E +  +K++    +  E E    ER + +E+     E+   + +
Sbjct: 786 KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE 845

Query: 242 KKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEE 301
           + +   +EG+   E EG     E+E   G  G GE    E   +   +G+ +     E E
Sbjct: 846 EGEGEEEEGEGKGEEEGEEGEGEEE---GEEGEGEGEEEEGEGEGEEEGEGEGE-EEEGE 901

Query: 302 KMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWN 361
             G  E  G+G+E  G  + EE       +      + ++ E E  + E  GEE    W 
Sbjct: 902 GEGEEEGEGEGEEEEGEGKGEEEGEEGEGE-----GEEEEGEGEGEDGEGEGEEEEGEW- 955

Query: 362 QGSREQ 367
           +G  E+
Sbjct: 956 EGEEEE 961



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/206 (22%), Positives = 84/206 (40%), Gaps = 19/206 (9%)

Query: 164  GITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERN 223
            G   + K  R E +E+      +G++      + E +  +++ + + ++E EE    E  
Sbjct: 817  GEVEEGKGEREEEEEEG-----EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG 871

Query: 224  DADEKH--PEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKE-----DAAGTSGLGE 276
            +  E     E  E    +  + +   +EG+   E EG  +G E+E     +  G  G GE
Sbjct: 872  EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE 931

Query: 277  LNSRE---QTNQSLRKGKKKK-RWHHEEEK---MGVLEEGGKGKEAAGSVRTEEVESRAY 329
                E   +      +G++++  W  EEE+    G  E  G+G+E  G    EE E    
Sbjct: 932  GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991

Query: 330  ADPCSRRKKRQQQEEEDLNLEDRGEE 355
             +      + + + EE+   E   EE
Sbjct: 992  EEEGEEEGEEEGEGEEEGEGEGEEEE 1017



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 35/159 (22%), Positives = 70/159 (44%), Gaps = 14/159 (8%)

Query: 186  KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
            +G+D G  + + E    + ++++   + EEE          E   E  E    + + ++ 
Sbjct: 940  EGED-GEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998

Query: 246  RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
              +EG+  +E EG  +G E+E+       GE+    +  +   +G++++     EE+   
Sbjct: 999  GEEEGEGEEEGEG--EGEEEEE-------GEVEGEVEGEEGEGEGEEEEGEEEGEER--- 1046

Query: 306  LEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEE 344
             E+ G+G+E   +   EE E   Y +      +RQ  EE
Sbjct: 1047 -EKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 18/194 (9%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E +E+    R + ++ G    + E    ++ K +R ++EEE     E  + +E+  E  E
Sbjct: 795 EGEEEETEGRGEEKEEGG---EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851

Query: 235 QNIRKSKKKKRRHQEGKVS--------DEREGTTKGNEKEDAAGTS----GLGELNSREQ 282
           +      +++    EG+          +E EG  +G E+ +  G      G GE     +
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911

Query: 283 TNQSLRKGKKKKRWHHEEEKMGVLEEG-GKGKEAAGSVRTEEVESRAYADPCSRRKKRQQ 341
             +   +GK ++    E E  G  EEG G+G++  G    EE E     +     +  ++
Sbjct: 912 GEEEEGEGKGEEEGE-EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE-GEGEGEEE 969

Query: 342 QEEEDLNLEDRGEE 355
            E E    E  GEE
Sbjct: 970 GEGEGEEGEGEGEE 983



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 6/126 (4%)

Query: 196  QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGK-VSD 254
            + E +  +++ +   ++EE E    E  + +E+     E+      + +   +EG+   +
Sbjct: 976  EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035

Query: 255  EREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKE 314
            E EG  +G E+E      G GE N R +  +   +GK ++    E E+    EE  K  +
Sbjct: 1036 EEEGEEEGEEREK----EGEGEENRRNREEEEEEEGKYQETGEEENERQDG-EEYKKVSK 1090

Query: 315  AAGSVR 320
              GSV+
Sbjct: 1091 IKGSVK 1096



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 22/169 (13%)

Query: 208 KRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDER--EGTTKGNEK 265
           K +   E E     R D   +      ++ +  +++K    +G+   ER  EG  +  EK
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699

Query: 266 EDAAGTSG-LGELNSREQ-----TNQSLRKGKKKKRW---------HHEEEKMGVLEEGG 310
           E+     G   E   REQ      NQ + +G +++             EEEK G  +E G
Sbjct: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759

Query: 311 KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQ----EEEDLNLEDRGEE 355
           +G+E  G    EE E R   +   + +K +++    E E+   E RGEE
Sbjct: 760 EGEEVEGEREKEEGE-RKKEERAGKEEKGEEEGDQGEGEEEETEGRGEE 807



 Score = 33.5 bits (75), Expect = 0.31
 Identities = 40/180 (22%), Positives = 73/180 (40%), Gaps = 17/180 (9%)

Query: 201 PPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTT 260
           P +K+KK++   E  + TA   ND  +++ E +E  +++ K  K+   +G    +   T 
Sbjct: 519 PVQKQKKQQTIGELTQDTALTENDDSDEYEEMSE--MKEGKACKQHVSQGIFMTQPATTI 576

Query: 261 KG---------NEKEDAAGTSGLG----ELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +           EKE A  + G G    E+ + E+ N  +  G+K+K     ++     E
Sbjct: 577 EAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEE-NVKVHGGRKEKTEILSDDLTDKAE 635

Query: 308 -EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSRE 366
              GK K    +    E       +  S   +  Q EE +   +D+G        +G +E
Sbjct: 636 VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695



 Score = 32.0 bits (71), Expect = 0.91
 Identities = 26/124 (20%), Positives = 48/124 (38%), Gaps = 9/124 (7%)

Query: 196  QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
            + E +   +++ +   +EEEE       + +E   E  E+   +  +++ +  EG    E
Sbjct: 998  EGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG----E 1053

Query: 256  REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRK-----GKKKKRWHHEEEKMGVLEEGG 310
                 +  E+E+       GE  +  Q  +  +K     G  K   H   +K  V    G
Sbjct: 1054 ENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQG 1113

Query: 311  KGKE 314
             GKE
Sbjct: 1114 NGKE 1117


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 66/290 (22%), Positives = 123/290 (42%), Gaps = 11/290 (3%)

Query: 86  QIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTD 145
           Q ++  KE  R    +     +K  +   L +G +  +K  ES    + +  KS K+  D
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS-KVTVD 288

Query: 146 EMLLQACEGR----TAHKAARLGITMKA-KLARLEAQEQAFLARLKGQDPGAPQLQSESK 200
             ++ A E +    TA +    G   K  K  +   +E+    + KG      +   E+ 
Sbjct: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348

Query: 201 PPKKKKKKRRQKEEEEATAS-ERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGT 259
              K++++R+++EEEE     E  +A  K  E  EQ  R+ KK+K + ++ ++  E +  
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLL 408

Query: 260 TKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSV 319
           TK +++E  A      +L   +      +    KKR  +E++K   + +  + KE + S+
Sbjct: 409 TK-SQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM 467

Query: 320 R-TEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQS 368
                VE      P         + EE+ + ED G +   W    S E++
Sbjct: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDD--WEAMASDEET 515



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 57/296 (19%), Positives = 121/296 (40%), Gaps = 59/296 (19%)

Query: 121 KPNKDLESCSDDDNQGSKSPKILTDEMLL--QACEGRTAHKAARLGITMKAKL---ARLE 175
           KP  ++ S SDDD+  +K PK    +     +  +G    +     I  ++++       
Sbjct: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG 187

Query: 176 AQEQAFLARLKGQ------------------DPGAPQLQSESKPPKKKKKKRRQKEEEEA 217
            +   FL   KGQ                  D  + ++++ ++   +KK++ R+K +EE 
Sbjct: 188 DESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEE- 246

Query: 218 TASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKV------------------------S 253
            A  R   +++  E  +++  K K+ +R+ +E  V                         
Sbjct: 247 KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE 306

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVL---EEGG 310
           D+ EG  K  +K+   G         +E+  +  +KG  K      +E +  L   EE  
Sbjct: 307 DDNEGDKKKKDKKKKKG--------EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358

Query: 311 KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSRE 366
           K +E     R EE+E++   +    ++KR+++++++   ++R ++  +   +  RE
Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQRE 414



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 43/184 (23%), Positives = 79/184 (42%), Gaps = 8/184 (4%)

Query: 118 GGEKPNKDL---ESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKL--- 171
           G E P+KD    +    +D +  K P+ L  + + ++ E   A +    G+  K +    
Sbjct: 430 GVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPP 489

Query: 172 ARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPE 231
              E +E    A L   +  A   ++E     K   + ++  EEE    E  + DE+  E
Sbjct: 490 VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE 549

Query: 232 HAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGK 291
             E+   +S+  +   ++ KVSDE++ + K  +K+ +   S   E +S +   +  R   
Sbjct: 550 EEEEE-GESEGSEGDEEDEKVSDEKD-SGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYD 607

Query: 292 KKKR 295
           K KR
Sbjct: 608 KAKR 611



 Score = 35.4 bits (80), Expect = 0.083
 Identities = 46/204 (22%), Positives = 81/204 (39%), Gaps = 34/204 (16%)

Query: 180 AFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEE-------------EATASERNDAD 226
           A  A ++G      Q   +SK  KKK+KK++  +E+             +   ++R    
Sbjct: 21  ALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVA 80

Query: 227 EKHPEHAEQNIRKSKKKKRRHQEGKV-------SDEREGTTKGNEKEDAAGTSGLGELNS 279
            K  E+ E+    SK KK++ Q+GK        S+E E     ++K            + 
Sbjct: 81  VKPTENNEEEF-TSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDD 139

Query: 280 REQTNQSLRKGKKK-----KRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCS 334
            +  N+  +K K K     K+W   EE     +E    K    S      ES   +D   
Sbjct: 140 DDDFNKLPKKAKGKAQKSNKKWDGSEE-----DEDNSKKIKERSRINSSGESGDESDEFL 194

Query: 335 RRKKRQQQEEEDL---NLEDRGEE 355
           + +K Q++ +++    N+E   E+
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNED 218



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 39/198 (19%), Positives = 74/198 (37%), Gaps = 10/198 (5%)

Query: 165 ITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKP---PKKKKKKRRQKEEEEATASE 221
           +T   + AR  A+    L + +G +  +     + +P    KK+KK  +Q E +E + S 
Sbjct: 408 LTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESM 467

Query: 222 RNDAD----EKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGEL 277
              A     E+     E+     + ++    E    D+ E      E E   G     E+
Sbjct: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEV 527

Query: 278 NSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRK 337
               +  +   + +++     EEE+     EG +G E    V  E+   +      S+  
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEM 587

Query: 338 KRQQQEEEDLNLEDRGEE 355
               + + D   +DR +E
Sbjct: 588 SSDSEYDSD---DDRTKE 602


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 55/227 (24%), Positives = 100/227 (44%), Gaps = 26/227 (11%)

Query: 167 MKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDAD 226
           ++ +  ++  QE+    + K       +L+ + K  +++KK R Q+E+ +    +  + +
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 227 EKHPEHAEQNIRKSKK-----KKRRHQEGKVSDEREGTTKGNEK-----EDAAGTSGLGE 276
           EK  E  E+  R+ ++     K+ R QE K+ D+ E   + +E+     E       + E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383

Query: 277 LNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRR 336
              + Q  + +R+ +KK R   EEE M   EE  + K+       EE E +    P  + 
Sbjct: 384 QEEKMQEEERIREREKKMR--EEEETMREQEEKMQ-KQEENMWEQEEKEWQQQRLPEQKE 440

Query: 337 K-----KRQQQEEEDLNLEDR--------GEETFRWWNQGSREQSMQ 370
           K     K Q+QEE+    E++        G+E   W  +  REQ  Q
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 487



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 43/197 (21%), Positives = 87/197 (44%), Gaps = 24/197 (12%)

Query: 184 RLKGQDPGAPQLQSESKPPKKK-KKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKK 242
           R+  QD    + +   +  KK  +++ + +EE++    E+   D++     E+ +R+ +K
Sbjct: 508 RMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK 567

Query: 243 KKR------RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRW 296
           K R      R QE K+ ++ E   +  EK        + E   + Q  +     +++K W
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEK--------MWEQEEKMQEQEEKMWEQEEKMW 619

Query: 297 HHEEE-KMG-----VLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLE 350
             EEE KM      + E+  K +E    +  +E + R   +    ++++ Q +EE +  +
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679

Query: 351 DRGEETFRWWNQGSREQ 367
              EE  +   +  REQ
Sbjct: 680 ---EEKMQGQEEKMREQ 693



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 29/167 (17%), Positives = 79/167 (47%), Gaps = 5/167 (2%)

Query: 204 KKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGN 263
           ++++K+ ++EEE     E    +++     ++     +++K + QE K+ ++ E   +  
Sbjct: 563 REREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622

Query: 264 EKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEE 323
           E++       +      +   Q  +  +++++   +EEKM   EE  +G+E    +R +E
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE--KMREQE 680

Query: 324 VESRAYADPCSRRKKRQQQEEEDLNLEDR---GEETFRWWNQGSREQ 367
            + +   +    ++++ + +EE +  ++    G+E   W  +  RE+
Sbjct: 681 EKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK 727



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/171 (23%), Positives = 78/171 (45%), Gaps = 15/171 (8%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E +E+ +    K Q+      + E K  +++++ + Q++EE     E    +++     +
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ 651

Query: 235 QNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKK 294
           +   + +++K R QE K+  + E   +  EK          E   REQ  +   +G+++K
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQ------EEKMREQEEKM--RGQEEK 703

Query: 295 RWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEE 345
            W  +EEKM   EE   G+E    +R +E   R   D   + ++R  + EE
Sbjct: 704 MW-GQEEKMWGQEEKMWGQE---EMREKEERIR---DQKEKMQERLPEHEE 747



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 43/191 (22%), Positives = 84/191 (43%), Gaps = 18/191 (9%)

Query: 196 QSESKPPKKKKKKRRQKE---EEEATASERNDA---DEKHPEHAEQNIRKSKK-----KK 244
           + E K  K+++K  RQ+E   E+E    E+ +     EK     E+ +R+ +K     KK
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304

Query: 245 RRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMG 304
            R QE ++ ++ E   +  EK          +     +  + +R+ ++K R   +EE+M 
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR--DQEERMW 362

Query: 305 VLEEGGKGKEAAGSVRT---EEVESRAYADPCSRRKKRQQQEEEDLNLEDR--GEETFRW 359
             +E  + KE     +    E+ E     +    R+K+ ++EEE +  ++    ++    
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422

Query: 360 WNQGSREQSMQ 370
           W Q  +E   Q
Sbjct: 423 WEQEEKEWQQQ 433



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 44/203 (21%), Positives = 94/203 (46%), Gaps = 17/203 (8%)

Query: 166 TMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK-EEEEATASERND 224
           TM+ +  +++ QE+    + +       + Q +  P +K+K   ++K +E+E    E+ +
Sbjct: 407 TMREQEEKMQKQEENMWEQEE------KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460

Query: 225 ADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTN 284
                 E   Q  +  +++K R QE ++  E+E   +  E++       + E + R +  
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMW-EQEEKMRDQEQKMWDQEERMWEQDERLREK 519

Query: 285 QSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEE 344
           +  R  ++KK W  EE+    + E  K +E     +T + E +   +   R ++++ +EE
Sbjct: 520 EE-RMREQKKMWQQEEK----MREEKKTQEQ--EKKTWDQEEKMREEERMREREKKMREE 572

Query: 345 EDLNLEDRGEETFRWWNQGSREQ 367
           E++  E   EE  +   +  REQ
Sbjct: 573 EEMMREQ--EEKMQEQEEKMREQ 593



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 54/210 (25%), Positives = 87/210 (41%), Gaps = 18/210 (8%)

Query: 170 KLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKH 229
           K    E QE+    RL   +    QL  +    K ++ K    + +  T  E     E+ 
Sbjct: 186 KKKNAELQEKL---RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 242

Query: 230 PEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNS--REQTNQSL 287
               E+ IRK ++K  R +E     E+EG  +  E++       L E     REQ  + L
Sbjct: 243 LREQEKKIRKQEEKMWRQEERL--REQEGKMREQEEKMRRQEKRLREQEKELREQ-EKEL 299

Query: 288 RKGKK----KKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQE 343
           R+ KK    +++   +EEKM   EE  + +E     + E +  +        +K R Q+E
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359

Query: 344 ---EEDLNL---EDRGEETFRWWNQGSREQ 367
              E+D  L   E+R  E  + W Q  + Q
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQ 389



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 16/186 (8%)

Query: 194 QLQSESKPPKKKKKKRRQK----EEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQE 249
           ++  + K   +++K R Q+    E+EE    +     ++     EQ+ R  +K++R  ++
Sbjct: 467 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526

Query: 250 GKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHE-----EEKMG 304
            K+  + E   +  + ++    +   E   RE+  + +R+ +KK R   E     EEKM 
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE--ERMREREKKMREEEEMMREQEEKMQ 584

Query: 305 VLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGS 364
             EE  K +E    +  +E + +   +    ++++  ++EE+  ++++ E     W Q  
Sbjct: 585 EQEE--KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE---MMWEQEE 639

Query: 365 REQSMQ 370
           + Q  +
Sbjct: 640 KMQEQE 645



 Score = 32.3 bits (72), Expect = 0.70
 Identities = 24/128 (18%), Positives = 62/128 (48%), Gaps = 6/128 (4%)

Query: 173 RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEH 232
           +++ QE+    + +       ++  + +  +++++K R++EE+     E+    E+  + 
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685

Query: 233 AEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKK 292
            E+ +R+ +++K R QE K+  + E      EK       G  E+  +E+  +  ++  +
Sbjct: 686 QEEKMRE-QEEKMRGQEEKMWGQEEKMWGQEEK-----MWGQEEMREKEERIRDQKEKMQ 739

Query: 293 KKRWHHEE 300
           ++   HEE
Sbjct: 740 ERLPEHEE 747


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 46/199 (23%), Positives = 93/199 (46%), Gaps = 17/199 (8%)

Query: 171  LARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERN-----DA 225
            L R E   +     L+ Q+ G   L+ E +  +++++++  KEE++    ER      D 
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412

Query: 226  DEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQ--- 282
            D K  E  +Q  R+ + +K R +E +V   +E   K  E+E         +    EQ   
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVR-RQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471

Query: 283  --TNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQ 340
                Q L + ++ +++  EE+++   E   K +E    +R++E E +   +     ++++
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ--ELRSQEPERKFLEEEQQLHRQQR 1529

Query: 341  Q----QEEEDLNLEDRGEE 355
            Q    QEE+ L  ++RG++
Sbjct: 1530 QRKFLQEEQQLRRQERGQQ 1548



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 46/203 (22%), Positives = 93/203 (45%), Gaps = 24/203 (11%)

Query: 168 KAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADE 227
           + ++ RLE QE+    RLK ++P   + Q   K  ++++++++Q   E+    E+    E
Sbjct: 604 REEVERLE-QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 228 KHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSL 287
           +  E  EQ +++  +++RR QE  +++E +   +   K      S + +   + ++    
Sbjct: 663 EEEERLEQRLKREHEEERREQE--LAEEEQEQARERIK------SRIPKWQWQLESEADA 714

Query: 288 RKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDL 347
           R+ K   R   +E +    E+  K +     ++ +E E          R  RQQQEE   
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE----------RAHRQQQEE--- 761

Query: 348 NLEDRGEETFRWWNQGSREQSMQ 370
             E R + T++W  +   E+  Q
Sbjct: 762 --EQRRDFTWQWQAEEKSERGRQ 782



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 40/172 (23%), Positives = 81/172 (47%), Gaps = 21/172 (12%)

Query: 194  QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
            Q + E    ++++K+RRQ++E +    E+   +E+     E+  R+ ++++R++++ K  
Sbjct: 907  QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966

Query: 254  DEREGTTKGNEKEDAAGTSGLGELNSREQTNQS----LRKGKKKKR---WHHEEEKMGVL 306
             ++E    G E E         +    E+  Q     LR+ ++K+R   W  +  K   L
Sbjct: 967  QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026

Query: 307  EEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR---GEE 355
            ++     E    +R E  + R       + ++RQ +EEE+L  E+    GEE
Sbjct: 1027 QQ-----EEEQLLREEREKRRL------QERERQYREEEELQQEEEQLLGEE 1067



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 43/173 (24%), Positives = 84/173 (48%), Gaps = 25/173 (14%)

Query: 195  LQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSD 254
            LQ E +  +++++++R+++E+E    E    +E+  +  EQ +R+ ++K+RR        
Sbjct: 906  LQEEEEELQREEREKRRRQEQERQYRE----EEQLQQEEEQLLREEREKRRRQ------- 954

Query: 255  EREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKE 314
            ERE   + ++K        LGE   + +  +  +K ++++    EEE++ + EE  K   
Sbjct: 955  ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL-LREEREK--- 1010

Query: 315  AAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
                 R  +   R Y     R+K   QQEEE L  E+R +   +   +  RE+
Sbjct: 1011 -----RRRQEWERQY-----RKKDELQQEEEQLLREEREKRRLQERERQYREE 1053



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 55/243 (22%), Positives = 109/243 (44%), Gaps = 19/243 (7%)

Query: 120  EKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAAR--LGITMKAKLARLEAQ 177
            E+  K LE   +   +  +  K   +E LLQ  E +  H+  R    +  + +L R E  
Sbjct: 1443 ERERKFLEE--EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500

Query: 178  EQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASE-----RNDADEKHPEH 232
             +     L+ Q+P    L+ E +  +++++++  +EE++    E     R D D K  E 
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE- 1559

Query: 233  AEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKK 292
             E+ +R+ +++++  ++ +    R    K   +E         +   R++  Q LR+ + 
Sbjct: 1560 -EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618

Query: 293  KKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
            +K    E+E++  L+E    +E     R E        +P  RR++R+QQ   D + + R
Sbjct: 1619 RK--FREDEQL--LQE----REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670

Query: 353  GEE 355
             EE
Sbjct: 1671 EEE 1673



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 45/170 (26%), Positives = 82/170 (48%), Gaps = 19/170 (11%)

Query: 194  QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHP----EHAEQNIRKSKKKKRRHQE 249
            QLQ E +   ++++++R+++E E    +     +K      E  E+  R+ ++KK R +E
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994

Query: 250  GKVSDE----REGTTKGNEKEDAAGTSGLGELNSREQT----NQSLRKGKKKKRWHHEEE 301
                +E    RE   K   +E         EL   E+      +  R+ ++++R + EEE
Sbjct: 995  ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054

Query: 302  KMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED 351
            ++   EE   G+E   + R +E+E R Y     R+++  QQEEE L  E+
Sbjct: 1055 ELQQEEEQLLGEERE-TRRRQELE-RQY-----RKEEELQQEEEQLLREE 1097



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 40/193 (20%), Positives = 89/193 (46%), Gaps = 10/193 (5%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E Q+Q  L R +       + + E +  ++++++RR+++EE      R + +E+     E
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR----E 348

Query: 235 QNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKK 294
           Q +R+ ++++RR Q+ +   E E   +   +E             + +  Q LR+ ++ +
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408

Query: 295 RWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGE 354
           R    E+++   ++  + ++       E  E +   +   +R KR+Q+E  D     R E
Sbjct: 409 R----EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD--WLKREE 462

Query: 355 ETFRWWNQGSREQ 367
           ET R   +  ++Q
Sbjct: 463 ETERHEQERRKQQ 475



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 25/177 (14%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
           QL+ E +  ++++ +R Q+   E     R   +E+H +  EQ  R+ ++ KR  +E +  
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQL-RREQEEERHEQKHEQE-RREQRLKREQEERRDW 457

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
            +RE  T+ +E+E             R+Q  +  ++ ++++RW   EE+    E   + +
Sbjct: 458 LKREEETERHEQE------------RRKQQLKRDQEEERRERWLKLEEE----ERREQQE 501

Query: 314 EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
                +R E+ E R        ++ ++Q+EEE L    R E+  R   +  REQ ++
Sbjct: 502 RREQQLRREQEERR-------EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 40/194 (20%), Positives = 82/194 (42%), Gaps = 12/194 (6%)

Query: 173  RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEH 232
            R + +E+ +    K Q      L  E +  ++++++++ +EEEE    E     E+  + 
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 233  AEQNIRKSKKKK-----------RRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSRE 281
              Q   +  +KK           R  +E +   ERE   +  E+        LGE     
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071

Query: 282  QTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQ 341
            +  +  R+ +K++    EEE++ + EE  K +      +  E E     +    R++R++
Sbjct: 1072 RRQELERQYRKEEELQQEEEQL-LREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130

Query: 342  QEEEDLNLEDRGEE 355
            +  ++L  + R EE
Sbjct: 1131 RRRQELERQYREEE 1144



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 40/176 (22%), Positives = 80/176 (45%), Gaps = 15/176 (8%)

Query: 177 QEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQN 236
           QE+    RLK Q+    +LQ   +    +++ RR++EE      +R +      E  EQ 
Sbjct: 511 QEERREQRLKRQEE-EERLQQRLR---SEQQLRREQEERREQLLKREEEKRLEQERREQR 566

Query: 237 IRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRW 296
           +++ ++++R     +  + R+   K  ++E         E+   EQ  +  R+ + K+  
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ--EERREQRLKREE 624

Query: 297 HHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
             EE +  +L+   + +     +R E+ E         RR++R ++EEE+  LE R
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQE---------RREQRLKREEEEERLEQR 671



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 53/231 (22%), Positives = 98/231 (42%), Gaps = 39/231 (16%)

Query: 141  KILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESK 200
            K   DE LLQ  E +  H+  R               ++ FL          PQL+ + +
Sbjct: 1620 KFREDEQLLQEREEQQLHRQER---------------DRKFLEE-------EPQLRRQER 1657

Query: 201  PPKKKKKKRRQKEEEEATASE-------RNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
              + +  + R+  EEE    E       R + D K  E  EQ +R+ +++++  QE +  
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE-EQQLRRQERERKFLQEEQQL 1716

Query: 254  DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
              +E   K  E+E     +   +L  +E+  + L   +++ R   EE+++   E   K +
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILE--EEQLRPEREEQQLRRQERDRKFR 1774

Query: 314  EAAGSVRTEEVESRAYADPCSRR-----KKRQQQEEEDLNLEDRGEETFRW 359
            E    +R E  E +  +    R+     + RQ++EE+ L  + R +  +RW
Sbjct: 1775 EEE-QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR-DGKYRW 1823



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 42/210 (20%), Positives = 97/210 (46%), Gaps = 19/210 (9%)

Query: 141  KILTDEMLLQACEGRTAHKAAR-LGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSES 199
            K   +E LLQ  E +   +  R      + +  R + +E+ FL     Q+    + Q   
Sbjct: 1668 KFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL-----QEEQQLRRQELE 1722

Query: 200  KPPKKKKKKRRQKEEEEATASERN----DADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
            +  +++++ R++ E+E+    ER     + ++  PE  EQ +R+ ++ ++  +E ++  E
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782

Query: 256  REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEA 315
            RE     +++ D        E   +E+  Q LR  ++  ++  EEE++ + E+  +    
Sbjct: 1783 REEQQLRSQESDRKFREE--EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR---- 1836

Query: 316  AGSVRTEEVESRAYADPCSRRKKRQQQEEE 345
               +R E        +  + ++K +++E+E
Sbjct: 1837 ---LRQERDRQYRAEEQFATQEKSRREEQE 1863



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 41/192 (21%), Positives = 84/192 (43%), Gaps = 19/192 (9%)

Query: 194 QLQSESKPPKKKKKKR-----RQKEEEEATASERNDADEKH-PEHAEQNIRKSKKKKRRH 247
           Q Q+E K  + +++       R++ E +  A ER   +++  PE  E+  R+ ++++R  
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEK----- 302
           +   + +E +   +   ++      GL E   R ++ +  R   +K RW  EEE+     
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR--DQKWRWQLEEERKRRRH 887

Query: 303 ----MGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
                  L+E  + ++       EE++         + ++RQ +EEE L  E+  E+  R
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE--EQLLR 945

Query: 359 WWNQGSREQSMQ 370
              +  R Q  +
Sbjct: 946 EEREKRRRQERE 957



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 39/194 (20%), Positives = 87/194 (44%), Gaps = 18/194 (9%)

Query: 177 QEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQN 236
           +E+  L +L+ Q+    + + E +  + +++++ ++++EE    ER +  E+  E  E+ 
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE----ERREQQEERREQQER- 327

Query: 237 IRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRW 296
            R+ ++++R  Q  +  +ER       E+E+      L      E+  Q LR+ ++ +R 
Sbjct: 328 -REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386

Query: 297 HHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEET 356
                +  +  E    +E    +R E+            R+++Q + E+ L  E   E  
Sbjct: 387 QQLRREQQLRREQQLRREQ--QLRREQ----------QLRREQQLRREQQLRREQEEERH 434

Query: 357 FRWWNQGSREQSMQ 370
            +   Q  REQ ++
Sbjct: 435 EQKHEQERREQRLK 448



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 36/161 (22%), Positives = 71/161 (44%), Gaps = 3/161 (1%)

Query: 194  QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
            Q + E    ++++K+RRQ+ E +    +    +E+     E+  R+ ++++R+++E +  
Sbjct: 997  QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 254  DEREGTTKGNEKEDAAGTSGLGELNSREQTNQS---LRKGKKKKRWHHEEEKMGVLEEGG 310
             + E    G E+E         +    E+  Q    L + + +KR   E E+    EE  
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 311  KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED 351
            + +E        E   R   +   R ++  QQEEE L  E+
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 46/195 (23%), Positives = 89/195 (45%), Gaps = 26/195 (13%)

Query: 184  RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEE--------ATASERNDAD--------- 226
            R + +D   P+ +   +  +K+ K+R +K +EE             R + D         
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344

Query: 227  ----EKHPEHAEQNIRKSKKKKRRHQE-GKVSDEREGTTKGNEKEDAAGTSGLGELNSRE 281
                E+ P   ++  RK ++++ RHQE G+   E E   +  E+E         +L  +E
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE-RKFLKEEQQLRCQE 1403

Query: 282  QTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQ 341
            +  Q LR+ + +K +  EE+++   E   K +E    VR +E E +   +    R++R +
Sbjct: 1404 R-EQQLRQDRDRK-FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461

Query: 342  Q-EEEDLNLEDRGEE 355
            +  EE+  L++R E+
Sbjct: 1462 KFREEEQLLQEREEQ 1476



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 47/217 (21%), Positives = 97/217 (44%), Gaps = 32/217 (14%)

Query: 141  KILTDEMLLQACEGRTAHKAAR-LGITMKAKLARLEAQEQAFLA---RLKGQDPGAPQLQ 196
            K   +E L Q  E +   +  R     ++ +  R + QE+ F+    +L+ Q+ G  QL+
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE-GQQQLR 1614

Query: 197  SESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRH-QEGKVSDE 255
             E     ++ ++  Q+ EE+     R + D K  E   Q  R+ ++++ RH ++ K  +E
Sbjct: 1615 QERDRKFREDEQLLQEREEQQL--HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672

Query: 256  REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEA 315
             +   +G E                    Q LR+ ++ +++  EE+++   E   K  + 
Sbjct: 1673 EQLLQEGEE--------------------QQLRRQERDRKFREEEQQLRRQERERKFLQE 1712

Query: 316  AGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
               +R +E+E +   +     + RQ+ E+E L  ++R
Sbjct: 1713 EQQLRRQELERKFREE----EQLRQETEQEQLRRQER 1745



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 37/181 (20%), Positives = 84/181 (46%), Gaps = 21/181 (11%)

Query: 196 QSESKPPKKKKKKRR--QKEEEEATASERND--ADEKHPEHAEQNIRKSKKKKRRHQEGK 251
           + E K  +++ +++R  Q+EEE+    ER +   + +  E  +Q +R+ ++ +R+ +E +
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314

Query: 252 VSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGK 311
              + E   +   +E              E+  Q LR+ ++++R    E+++   +E  +
Sbjct: 315 REQQEERREQQERRE-----------QQEERREQQLRREQEERR----EQQLRREQEEER 359

Query: 312 GKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED--RGEETFRWWNQGSREQSM 369
            ++     + EE   +        R+++Q + E+ L  E   R E+  R   Q  REQ +
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419

Query: 370 Q 370
           +
Sbjct: 420 R 420



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 49/228 (21%), Positives = 98/228 (42%), Gaps = 22/228 (9%)

Query: 145 DEMLLQACEGRTAHKAARLGITMKAKLARL--EAQEQAFLARLKGQDPGAPQLQSESKPP 202
           +E  LQ+C+G    +        + +L  L  + +E+    R + QD      Q E +  
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR---VFQEEEEKE 245

Query: 203 KKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKG 262
            +K++   +KEEE+    E     ++  +  E+ +RK ++++ R +  +   +++   + 
Sbjct: 246 WRKRETVLRKEEEK--LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303

Query: 263 NEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTE 322
            +           E   REQ  Q  R+ ++++R   EE +   L    + +      R +
Sbjct: 304 QQLRRKQ------EEERREQ--QEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355

Query: 323 EVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
           E E R        ++ R++QEEE    + R E+  R   Q  REQ ++
Sbjct: 356 EEERR-------EQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/199 (21%), Positives = 88/199 (44%), Gaps = 16/199 (8%)

Query: 175  EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDA---DEKHPE 231
            + Q Q  L  L G+     +   E +  + +++ R   EEE+    E+ +A   D K  E
Sbjct: 1260 DRQSQQDLQHLLGEQQ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQE 1316

Query: 232  HAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGK 291
              +    + ++K+RR +  +   E E   +  E++         +   R+   + LR  +
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR-----RQERDRKFREEELRHQE 1371

Query: 292  KKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED 351
            + +++  EE+++   E   K  +    +R +E E +   D    R ++ ++EE+ L+ ++
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD----RDRKFREEEQQLSRQE 1427

Query: 352  RGEETFRWWNQGSREQSMQ 370
            R +  FR   Q  R Q  +
Sbjct: 1428 R-DRKFREEEQQVRRQERE 1445



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/165 (21%), Positives = 77/165 (46%), Gaps = 20/165 (12%)

Query: 203  KKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKG 262
            ++++K+RR     +    E+   +++  +  E+ +++ +++KRR QE +     E   + 
Sbjct: 879  EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 263  NEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTE 322
             E           E   RE+  +  R+ ++++R + +++K+   EE   G+E        
Sbjct: 939  EE-----------EQLLREEREK--RRRQERERQYRKDKKLQQKEEQLLGEE-------P 978

Query: 323  EVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
            E   R   +   R ++  QQEEE L  E+R +   + W +  R++
Sbjct: 979  EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 38/182 (20%), Positives = 78/182 (42%), Gaps = 24/182 (13%)

Query: 196  QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
            Q E +  +++++KRRQ+ E +    E     ++   + +++ R   K +   ++     +
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237

Query: 256  REGTTKGNEKEDAAGTSG---------------LGELNSREQTNQSLRKGKKKKRWHHEE 300
             +   KG E E                      LGE   R++  Q  R+ +++ R   EE
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR-EQERRRWQQRDRHFPEE 1296

Query: 301  EKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQE----EEDLNLEDRGEET 356
            E++    E  + KEA    R  + E +   +    +++RQ+ +    EE+  L++R E+ 
Sbjct: 1297 EQL----EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352

Query: 357  FR 358
             R
Sbjct: 1353 LR 1354



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 36/166 (21%), Positives = 74/166 (44%), Gaps = 25/166 (15%)

Query: 194  QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
            Q + E    ++ +K+RRQ+ E +    E    +E      EQ +R+ ++K+RR +  +  
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEE------EQLLREEREKRRRQELERQY 1140

Query: 254  DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
             E E   +  E+        L E   + +  +  R+ ++++    EEE++   E+  + +
Sbjct: 1141 REEEEVQQEEEQL-------LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 314  EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRW 359
            E     R EE           R+K++Q+  +ED     R +  ++W
Sbjct: 1194 ERERQYREEE--------ELQRQKRKQRYRDED----QRSDLKWQW 1227



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 31/162 (19%), Positives = 71/162 (43%), Gaps = 14/162 (8%)

Query: 205 KKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNE 264
           ++K+ R   +E      R + D++  E  ++ + +   ++RR +  +   E     + +E
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 265 KEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE--EGGKGKEAAGSVRTE 322
           K++         L  R++  +     ++++ W   EE+    E  +  KG E       E
Sbjct: 157 KQE--------RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208

Query: 323 EVESRAYADPCSRRKKRQQQEEEDLNLEDR--GEETFRWWNQ 362
           ++  R   +   RRK R++++++    +DR   EE  + W +
Sbjct: 209 QLRRRELLE--LRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 46/237 (19%), Positives = 100/237 (42%), Gaps = 33/237 (13%)

Query: 162 RLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK--EEEEATA 219
           RL   ++++      QE+     LK ++    + +   +  K+++++RR +  + EE   
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586

Query: 220 SERNDADEKHPEHAEQNIRK---------SKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
            +R   +++  E  EQ +++          ++++R  +E    + R+   K  E+E+   
Sbjct: 587 QQRLKREQE--ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644

Query: 271 TSGLGELNSR-----EQTNQSLRKGKKKKRWHHEEEKMGVL--EEGGKGKEAAGS----- 318
                E   R     ++  +  R  ++ KR H EE +   L  EE  + +E   S     
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704

Query: 319 -----VRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
                   +  +S+ Y+ P  +  +R++QE+E+   + R  E+   W +  R    Q
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEE---KRRRRESELQWQEEERAHRQQ 758



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 43/173 (24%), Positives = 73/173 (42%), Gaps = 16/173 (9%)

Query: 203  KKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKG 262
            +++++ R   EEEE    E     E+      Q + +  +K+   Q+ +    RE   K 
Sbjct: 1045 ERERQYR---EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101

Query: 263  NEKEDAAGTSGLGELNSREQTNQSLRKGKKKKR-----WHHEEEKMGVLEEGGKGKEAAG 317
              +E         EL   E+  Q LR+ ++K+R       + EE+    EE    +E   
Sbjct: 1102 RRQERERQCREEEELQQEEE--QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159

Query: 318  SVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
              R +E+E R Y     R ++  QQEEE L  E++ +       Q   E+ +Q
Sbjct: 1160 KRRRQELE-RQY-----REEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206



 Score = 32.0 bits (71), Expect = 0.91
 Identities = 29/123 (23%), Positives = 53/123 (43%), Gaps = 9/123 (7%)

Query: 141  KILTDEMLLQACEGRTAHKAARLG-ITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSES 199
            K   +E L Q  E +      R G    + +  +LE QEQ        Q     Q  ++ 
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ- 1854

Query: 200  KPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGT 259
                   +K R++E+E     E+    E+  +  E++IR+ +K+++RH++      +EG 
Sbjct: 1855 -------EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907

Query: 260  TKG 262
              G
Sbjct: 1908 GHG 1910



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 41/209 (19%), Positives = 87/209 (41%), Gaps = 43/209 (20%)

Query: 141  KILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESK 200
            K   +E L Q  E     +  R    ++ +  R E +EQ              QL+ + +
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ--------------QLRRQER 1769

Query: 201  PPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR---RHQEGKVSDERE 257
              +K +++ + ++E E       ++D K  E  E+ +R+ +++++   + ++GK   E E
Sbjct: 1770 D-RKFREEEQLRQEREEQQLRSQESDRKFRE--EEQLRQEREEQQLRPQQRDGKYRWEEE 1826

Query: 258  GTTKGNEKEDAAGTSGLGELNSREQ-TNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAA 316
               +  E+E         +  + EQ   Q   + ++++ W  EE+K        + +E  
Sbjct: 1827 -QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK--------RRQERE 1877

Query: 317  GSVRTEEVESRAYADPCSRRKKRQQQEEE 345
              +R E +             +RQQ+EE+
Sbjct: 1878 RKLREEHI-------------RRQQKEEQ 1893


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 25/228 (10%)

Query: 161 ARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATAS 220
           +R G   ++K +R  +Q ++   + K + P   + +S S    K + K + + EE+    
Sbjct: 222 SRSGSRSRSK-SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKI--- 277

Query: 221 ERNDADEKHPEHAEQNIRKSKKKKR-RHQEGKVSDEREGT-TKGNEKEDAAGTS------ 272
            +N+ +   P+    +  KSK K R R QE +V +E+ G+ ++G  +E +   S      
Sbjct: 278 -QNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRS 336

Query: 273 -GLGELNSREQT-NQSLRKGKKKKRWHHEEEKMG------VLEEGGKGKEAAGSVRTEEV 324
            G     SR ++ ++  RKG+K+ R                 + G K    AGS + ++ 
Sbjct: 337 KGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKK 396

Query: 325 E----SRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQS 368
           E    S++ +   S  K+R+  + E    E RGE      NQ +R +S
Sbjct: 397 EDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRS 444



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 39/217 (17%), Positives = 93/217 (42%), Gaps = 6/217 (2%)

Query: 127 ESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFL---A 183
           E   ++DN G   PK  +        + R+  +  R+    +  ++R  +QE++     +
Sbjct: 275 EKIQNNDNVGK--PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRS 332

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           R + +     + +S SK   K+K ++R +EE  + +  R+ ++      ++++ +    K
Sbjct: 333 RSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSK 392

Query: 244 KRRHQEGKVSDERE-GTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEK 302
           K++ ++   S  R    +   E+E A   S   E     +   + ++ + + R + + + 
Sbjct: 393 KKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKP 452

Query: 303 MGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKR 339
               E   + K A+ +    +  SR+ +   SR + R
Sbjct: 453 NLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSR 489



 Score = 32.7 bits (73), Expect = 0.54
 Identities = 31/156 (19%), Positives = 61/156 (39%), Gaps = 17/156 (10%)

Query: 207 KKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKE 266
           +K R  E++  +   R+ +  +    +    R S+K + R    K S  +      +   
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSK------SRSR 221

Query: 267 DAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVE- 325
             +G+    +  SR Q+    R  K+K R   +E+        GK +  +     E+++ 
Sbjct: 222 SRSGSRSRSKSRSRSQSRS--RSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQN 279

Query: 326 --------SRAYADPCSRRKKRQQQEEEDLNLEDRG 353
                   SR+ +   S+ K R + +E  +  E RG
Sbjct: 280 NDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRG 315


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 51/220 (23%), Positives = 94/220 (42%), Gaps = 22/220 (10%)

Query: 153 EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
           E R A   A+     + +   L  Q++  L R + ++    + + E    K+++  RRQ+
Sbjct: 734 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE-EEELARRKQEEALRRQR 792

Query: 213 EEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
           E+E A   +R + + +  E A + +  R+ ++++RR QE  +  + E   K   +E+ A 
Sbjct: 793 EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA- 851

Query: 271 TSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYA 330
                    R      LR  ++  R  HEEE+        K KE     + E +  R   
Sbjct: 852 --------QRRLEENRLRMEEEAARLRHEEEER-------KRKELEVQRQKELMRQRQQQ 896

Query: 331 DPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
               RR ++QQQ+++   ++     T   W Q S   + Q
Sbjct: 897 QEALRRLQQQQQQQQLAQMKLPSSST---WGQQSNTTACQ 933



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 9/171 (5%)

Query: 190 PGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRH 247
           P   QLQ   K    K ++ R++ E  A   E     ++     ++ I  R+ +++++R 
Sbjct: 715 PALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 774

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +E +++  ++      ++E         E   R+Q  ++LR+ ++++R   EEE+    E
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR--EEEERRKQEE 832

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
              K +E A     EE E++   +     + R + EEE   L    EE  R
Sbjct: 833 LLRKQEEEAAKWAREEEEAQRRLE-----ENRLRMEEEAARLRHEEEERKR 878


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 51/220 (23%), Positives = 94/220 (42%), Gaps = 22/220 (10%)

Query: 153 EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
           E R A   A+     + +   L  Q++  L R + ++    + + E    K+++  RRQ+
Sbjct: 761 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE-EEELARRKQEEALRRQR 819

Query: 213 EEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
           E+E A   +R + + +  E A + +  R+ ++++RR QE  +  + E   K   +E+ A 
Sbjct: 820 EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA- 878

Query: 271 TSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYA 330
                    R      LR  ++  R  HEEE+        K KE     + E +  R   
Sbjct: 879 --------QRRLEENRLRMEEEAARLRHEEEER-------KRKELEVQRQKELMRQRQQQ 923

Query: 331 DPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
               RR ++QQQ+++   ++     T   W Q S   + Q
Sbjct: 924 QEALRRLQQQQQQQQLAQMKLPSSST---WGQQSNTTACQ 960



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 9/171 (5%)

Query: 190 PGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRH 247
           P   QLQ   K    K ++ R++ E  A   E     ++     ++ I  R+ +++++R 
Sbjct: 742 PALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 801

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +E +++  ++      ++E         E   R+Q  ++LR+ ++++R   EEE+    E
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR--EEEERRKQEE 859

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
              K +E A     EE E++   +     + R + EEE   L    EE  R
Sbjct: 860 LLRKQEEEAAKWAREEEEAQRRLE-----ENRLRMEEEAARLRHEEEERKR 905


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 51/220 (23%), Positives = 94/220 (42%), Gaps = 22/220 (10%)

Query: 153 EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
           E R A   A+     + +   L  Q++  L R + ++    + + E    K+++  RRQ+
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE-EEELARRKQEEALRRQR 798

Query: 213 EEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
           E+E A   +R + + +  E A + +  R+ ++++RR QE  +  + E   K   +E+ A 
Sbjct: 799 EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA- 857

Query: 271 TSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYA 330
                    R      LR  ++  R  HEEE+        K KE     + E +  R   
Sbjct: 858 --------QRRLEENRLRMEEEAARLRHEEEER-------KRKELEVQRQKELMRQRQQQ 902

Query: 331 DPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
               RR ++QQQ+++   ++     T   W Q S   + Q
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSST---WGQQSNTTACQ 939



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 9/171 (5%)

Query: 190 PGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRH 247
           P   QLQ   K    K ++ R++ E  A   E     ++     ++ I  R+ +++++R 
Sbjct: 721 PALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +E +++  ++      ++E         E   R+Q  ++LR+ ++++R   EEE+    E
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR--EEEERRKQEE 838

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
              K +E A     EE E++   +     + R + EEE   L    EE  R
Sbjct: 839 LLRKQEEEAAKWAREEEEAQRRLE-----ENRLRMEEEAARLRHEEEERKR 884


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 51/220 (23%), Positives = 94/220 (42%), Gaps = 22/220 (10%)

Query: 153 EGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQK 212
           E R A   A+     + +   L  Q++  L R + ++    + + E    K+++  RRQ+
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE-EEELARRKQEEALRRQR 798

Query: 213 EEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
           E+E A   +R + + +  E A + +  R+ ++++RR QE  +  + E   K   +E+ A 
Sbjct: 799 EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA- 857

Query: 271 TSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYA 330
                    R      LR  ++  R  HEEE+        K KE     + E +  R   
Sbjct: 858 --------QRRLEENRLRMEEEAARLRHEEEER-------KRKELEVQRQKELMRQRQQQ 902

Query: 331 DPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
               RR ++QQQ+++   ++     T   W Q S   + Q
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSST---WGQQSNTTACQ 939



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 39/171 (22%), Positives = 76/171 (44%), Gaps = 9/171 (5%)

Query: 190 PGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNI--RKSKKKKRRH 247
           P   QLQ   K    K ++ R++ E  A   E     ++     ++ I  R+ +++++R 
Sbjct: 721 PALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +E +++  ++      ++E         E   R+Q  ++LR+ ++++R   EEE+    E
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR--EEEERRKQEE 838

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
              K +E A     EE E++   +     + R + EEE   L    EE  R
Sbjct: 839 LLRKQEEEAAKWAREEEEAQRRLE-----ENRLRMEEEAARLRHEEEERKR 884


>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 1153

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 40/160 (25%), Positives = 74/160 (46%), Gaps = 17/160 (10%)

Query: 119 GEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAAR-----LGITMKAKLA- 172
           G++ +  L + SD+D   ++   I+T+EM   A       K        L I +   LA 
Sbjct: 753 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD 812

Query: 173 --RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHP 230
             +L  Q+       K  +   P ++ +SK PKKK+KK ++KE          D ++K  
Sbjct: 813 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKE---------RDKEKKKE 863

Query: 231 EHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAG 270
           +  +++ +  KKK R+ +E +   +++   +    E+AAG
Sbjct: 864 KEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAG 903



 Score = 33.1 bits (74), Expect = 0.41
 Identities = 36/143 (25%), Positives = 54/143 (37%), Gaps = 12/143 (8%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSE---SKPPKKKKKKRRQKEEEEATASERNDADEKHPE 231
           E  E A  +    +DP  P    +    KP    +K   QK         RN    K PE
Sbjct: 780 EMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKH--------RNTETSKSPE 831

Query: 232 HAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGK 291
                + K K KK + +E K  ++     K  EKE         + + +E+  ++  K K
Sbjct: 832 KDVPMVEK-KSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKK 890

Query: 292 KKKRWHHEEEKMGVLEEGGKGKE 314
            KK+    EE  G   + G  +E
Sbjct: 891 SKKQPPGSEEAAGEPVQNGAPEE 913


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 56/249 (22%), Positives = 97/249 (38%), Gaps = 25/249 (10%)

Query: 116 TSGGEKPNKDLESCSDDDNQG-----SKSPKILTDEMLLQACEGRTAHKAARLGITMKAK 170
           T G EKP KD+ S S D  QG         K +  E ++++  GR    A+       + 
Sbjct: 586 TKGTEKP-KDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASG------SA 638

Query: 171 LARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHP 230
            + L  QE       + +D G      + +  K  + K+++K ++ +    ++ AD +  
Sbjct: 639 CSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK 698

Query: 231 EHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKG 290
               ++  KSKK+K+R ++   S     + +G + E     S       R   + S R+ 
Sbjct: 699 SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRS 758

Query: 291 KKKKRWHHEEEKMGVLEEGG--------KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQ 342
                   EE   G  +EGG         G++  G +     + RA     SR   R Q 
Sbjct: 759 LPA-----EEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQP 813

Query: 343 EEEDLNLED 351
              D + +D
Sbjct: 814 SSGDEDSDD 822



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 15/35 (42%), Positives = 21/35 (60%)

Query: 19 LLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVG 53
          L KHGW  G+GLG+   G T  + + +K D  G+G
Sbjct: 48 LQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMG 82



 Score = 30.0 bits (66), Expect = 3.5
 Identities = 30/175 (17%), Positives = 69/175 (39%), Gaps = 11/175 (6%)

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
           +G  P  P   S S  P +++++ +   +  +  +E   + +K       + +    +K 
Sbjct: 729 RGPKPEPPG--SGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKH 786

Query: 246 RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
           + +    S +R   TK + +         G+ +S + ++  L + K   ++  EEE+   
Sbjct: 787 KGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQ-KSPSQYSEEEEEEDS 845

Query: 306 LEEGGKGKEAAG--------SVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
             E  + +  +G        S R+    S A +D     ++R   ++   +  DR
Sbjct: 846 GSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR 900


>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
           isoform 1 [Homo sapiens]
          Length = 1112

 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 53/204 (25%), Positives = 86/204 (42%), Gaps = 25/204 (12%)

Query: 119 GEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAAR-----LGITMKAKLA- 172
           G++ +  L + SD+D   ++   I+T+EM   A       K        L I +   LA 
Sbjct: 662 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD 721

Query: 173 --RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHP 230
             +L  Q+       K  +   P ++ +SK PKKK+KK ++KE ++    E+    EK  
Sbjct: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDK----EKKKEKEKKA 777

Query: 231 EHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKG 290
           E  +  +  +           V          +E EDA  T   GE +  E  +Q  +  
Sbjct: 778 EDLDFWLSTTPPPAPAPAPAPVPST-------DECEDAK-TEAQGEEDDAEGQDQDKKSP 829

Query: 291 KKKKRWHHEEEKMGVLEEGGKGKE 314
           K KK+ H +E+     EE  KGK+
Sbjct: 830 KPKKKKHRKEK-----EERTKGKK 848



 Score = 32.3 bits (72), Expect = 0.70
 Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 13/116 (11%)

Query: 120 EKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQ 179
           EK +K+ E   +   +  K  + L D  L        A   A +  T + + A+ EAQ  
Sbjct: 757 EKKHKEKERDKEKKKEKEKKAEDL-DFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQ-- 813

Query: 180 AFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQ 235
                  G++  A     + K PK KKKK R KE+EE T  ++    +K P  +E+
Sbjct: 814 -------GEEDDAEGQDQDKKSPKPKKKKHR-KEKEERTKGKKK--SKKQPPGSEE 859


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 33/168 (19%), Positives = 71/168 (42%), Gaps = 20/168 (11%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           + + +  +K++ ++RQ+E E    +ER    ++  E   Q  R+  K + R ++ +    
Sbjct: 52  REKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRN 111

Query: 256 REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEA 315
           RE   KG  + D            R++  +  R+ +++++   + E+    E   + KE 
Sbjct: 112 RERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKE- 170

Query: 316 AGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQG 363
                              R+K+R+++ +E    E R E+  R W +G
Sbjct: 171 -------------------RKKERKKERKEKKKEEKRREDKKRKWGEG 199



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 32/164 (19%), Positives = 69/164 (42%), Gaps = 9/164 (5%)

Query: 204 KKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGN 263
           K+ ++ R ++ E    +ER +   +   H E++ +  ++K+R  Q  K  D +    +  
Sbjct: 15  KETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQ--KERDRQRQRERET 72

Query: 264 EKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEE 323
           E+E         +   + QT++   K + ++R    +       +GG+ ++     +TE 
Sbjct: 73  ERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDK----QTER 128

Query: 324 VESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
              R       R ++RQ+Q E      +   E  RW  +  R++
Sbjct: 129 ERDRERERQRQRERERQRQRERK---RETDRERQRWAEREERKK 169



 Score = 37.0 bits (84), Expect = 0.028
 Identities = 21/122 (17%), Positives = 53/122 (43%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E + Q    R + +     + + + +  ++K++  R +E       ER+   E+  +   
Sbjct: 75  ETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRER 134

Query: 235 QNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKK 294
           +  R+ +++++R +E K   +RE       +E         +   +E+  +  R+  KK+
Sbjct: 135 ERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKR 194

Query: 295 RW 296
           +W
Sbjct: 195 KW 196



 Score = 32.0 bits (71), Expect = 0.91
 Identities = 16/79 (20%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           Q+E +  ++++++R+++ E +     + + D +    AE   R+ +KK+R+ +  K   E
Sbjct: 125 QTERERDRERERQRQRERERQRQRERKRETDRERQRWAE---REERKKERKKERKKERKE 181

Query: 256 REGTTKGNEKEDAAGTSGL 274
           ++   K  E +      G+
Sbjct: 182 KKKEEKRREDKKRKWGEGI 200


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 47/210 (22%), Positives = 94/210 (44%), Gaps = 20/210 (9%)

Query: 131 DDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQE------QAFLAR 184
           D+  + +K  ++  ++   +A   +     AR     +A+  R   QE      Q  L +
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 666

Query: 185 LKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKK 244
            K ++    +  +E+K  +  +++ +++ E+E    ER + + +  E  EQ  + +++++
Sbjct: 667 KKEEEQERLRKAAEAK--RLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724

Query: 245 RRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMG 304
           RR QE ++  ERE      E+E A           +EQ  + L + KKK+      E+  
Sbjct: 725 RREQE-RLQAERE----LQEREKALRL-------QKEQLQRELEEKKKKEEQQRLAERQL 772

Query: 305 VLEEGGKGKEAAGSVRTEEVESRAYADPCS 334
             E+  K KEAAG+ +   V     +  C+
Sbjct: 773 QEEQEKKAKEAAGASKALNVTVDVQSPACT 802



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 12/170 (7%)

Query: 189 DPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQ 248
           D    + + E    +K KKK   K+ EE  A  + + + +     +Q     ++++RRHQ
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ-----EEEERRHQ 661

Query: 249 E---GKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
           E    K  +E+E   K  E +  A      E   +E+  Q  R+ +++++   E+E+   
Sbjct: 662 ELLQKKKEEEQERLRKAAEAKRLA-EQREQERREQERREQERREQERREQERREQERQLA 720

Query: 306 LEEGGKGKE---AAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
            +E  + +E   A   ++  E   R   +   R  + ++++EE   L +R
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 48/210 (22%), Positives = 92/210 (43%), Gaps = 21/210 (10%)

Query: 165 ITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERND 224
           + M  K + +E + Q  L  L+ ++  A QL+ +    K ++ KRR+ EE +    ER  
Sbjct: 526 LRMDPKCSFVEKERQR-LENLRRKEE-AEQLRRQ----KVEEDKRRRLEEVKLKREERL- 578

Query: 225 ADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEK---EDAAGTSGLGELNSRE 281
              +    A + + + K++K++  E K +   E T K  E+   E+ A      +     
Sbjct: 579 ---RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635

Query: 282 QTNQSLRKGKKKKRW-HHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQ 340
           +  +   +  ++ RW   EEE+    E   K KE       +  E++  A+   + ++ Q
Sbjct: 636 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695

Query: 341 QQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
           ++ E++   ++R E       Q  REQ  Q
Sbjct: 696 ERREQERREQERRE-------QERREQERQ 718



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 41/175 (23%), Positives = 81/175 (46%), Gaps = 15/175 (8%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           +LK ++     LQ+  +  + K++K++Q E++ A        DEK  +  E+ + + K K
Sbjct: 571 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFA------QIDEKTEKAKEERLAEEKAK 624

Query: 244 KRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKM 303
           K+     K  +E E   K  ++E+A     L +    E+ +Q L + KK++    E+E++
Sbjct: 625 KKA--AAKKMEEVEARRK--QEEEARRLRWLQQ-EEEERRHQELLQKKKEE----EQERL 675

Query: 304 GVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
               E  +  E     R E+           RR++ ++++E  L  ++R  E  R
Sbjct: 676 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQER 730



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 51/265 (19%), Positives = 109/265 (41%), Gaps = 15/265 (5%)

Query: 90  LSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLL 149
           + + T     PK + + ++  ++  L    E      +   +D  +  +  K+  +E L 
Sbjct: 520 IKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR 579

Query: 150 QACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKR 209
           +  + R   +  ++    K ++ +  AQ      + K +     + + ++   K ++ + 
Sbjct: 580 KVLQAR--ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 637

Query: 210 RQKEEEEATASERNDADEKHPEHAEQNIRKSKKKK------RRHQEGK-VSDEREGTTKG 262
           R+K+EEEA        +E+   H E      KKK+      R+  E K ++++RE   + 
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQEL---LQKKKEEEQERLRKAAEAKRLAEQREQERRE 694

Query: 263 NE-KEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRT 321
            E +E         E   REQ  Q   + +++++   + E+   L+E  K          
Sbjct: 695 QERREQERREQERREQERREQERQLAEQERRREQERLQAER--ELQEREKALRLQKEQLQ 752

Query: 322 EEVESRAYADPCSRRKKRQQQEEED 346
            E+E +   +   R  +RQ QEE++
Sbjct: 753 RELEEKKKKEEQQRLAERQLQEEQE 777


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 47/210 (22%), Positives = 94/210 (44%), Gaps = 20/210 (9%)

Query: 131 DDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQE------QAFLAR 184
           D+  + +K  ++  ++   +A   +     AR     +A+  R   QE      Q  L +
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQK 662

Query: 185 LKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKK 244
            K ++    +  +E+K  +  +++ +++ E+E    ER + + +  E  EQ  + +++++
Sbjct: 663 KKEEEQERLRKAAEAK--RLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720

Query: 245 RRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMG 304
           RR QE ++  ERE      E+E A           +EQ  + L + KKK+      E+  
Sbjct: 721 RREQE-RLQAERE----LQEREKALRL-------QKEQLQRELEEKKKKEEQQRLAERQL 768

Query: 305 VLEEGGKGKEAAGSVRTEEVESRAYADPCS 334
             E+  K KEAAG+ +   V     +  C+
Sbjct: 769 QEEQEKKAKEAAGASKALNVTVDVQSPACT 798



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 42/225 (18%), Positives = 100/225 (44%), Gaps = 9/225 (4%)

Query: 127 ESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLK 186
           +   +D  +  +  K+  +E L +  + R   +  ++    K ++ +  AQ      + K
Sbjct: 553 QKVEEDKRRRLEEVKLKREERLRKVLQAR--ERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610

Query: 187 GQDPGAPQLQSESKPPKKKKKKRRQKEEEEATA---SERNDADEKHPEHAEQNIRKSKKK 243
            +     + + ++   K ++ + R+K+EEEA      ++ + + +H E  ++   + +++
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 670

Query: 244 KRRHQEGK-VSDEREGTTKGNE-KEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEE 301
            R+  E K ++++RE   +  E +E         E   REQ  Q   + +++++   + E
Sbjct: 671 LRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE 730

Query: 302 KMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEED 346
           +   L+E  K           E+E +   +   R  +RQ QEE++
Sbjct: 731 R--ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQE 773



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 30/192 (15%)

Query: 202 PKKKKKKR----RQKEEEEATASERNDADE---------KHPEH------AEQNIRKSKK 242
           PK+K+++R    R+KEE E    ++ + D+         K  E       A + + + K+
Sbjct: 530 PKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 589

Query: 243 KKRRHQEGKVSDEREGTTKGNEK---EDAAGTSGLGELNSREQTNQSLRKGKKKKRW-HH 298
           +K++  E K +   E T K  E+   E+ A      +     +  +   +  ++ RW   
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ 649

Query: 299 EEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
           EEE+    E   K KE       +  E++  A+   + ++ Q++ E++   ++R E    
Sbjct: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE---- 705

Query: 359 WWNQGSREQSMQ 370
              Q  REQ  Q
Sbjct: 706 ---QERREQERQ 714



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 12/170 (7%)

Query: 189 DPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQ 248
           D    + + E    +K KKK   K+ EE  A  + + + +     +Q     ++++RRHQ
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ-----EEEERRHQ 657

Query: 249 E---GKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV 305
           E    K  +E+E   K  E +  A      E   +E+  Q  R+ +++++   E+E+   
Sbjct: 658 ELLQKKKEEEQERLRKAAEAKRLA-EQREQERREQERREQERREQERREQERREQERQLA 716

Query: 306 LEEGGKGKE---AAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
            +E  + +E   A   ++  E   R   +   R  + ++++EE   L +R
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 766



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 41/175 (23%), Positives = 81/175 (46%), Gaps = 15/175 (8%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           +LK ++     LQ+  +  + K++K++Q E++ A        DEK  +  E+ + + K K
Sbjct: 567 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFA------QIDEKTEKAKEERLAEEKAK 620

Query: 244 KRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKM 303
           K+     K  +E E   K  ++E+A     L +    E+ +Q L + KK++    E+E++
Sbjct: 621 KKA--AAKKMEEVEARRK--QEEEARRLRWLQQ-EEEERRHQELLQKKKEE----EQERL 671

Query: 304 GVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
               E  +  E     R E+           RR++ ++++E  L  ++R  E  R
Sbjct: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQER 726


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 40/185 (21%), Positives = 91/185 (49%), Gaps = 11/185 (5%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
           Q+Q + +   +++++ R++EE+     E+    E+  +  E+ +RK ++++ R QE ++ 
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK-QEEQMREQEEQMR 272

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
           ++ E   K  E+ +    +G  E   REQ  Q +R+ +++ R   EE+     E+ GK +
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ-MREQEEQMR-EQEEQMREQEEQMGKQE 330

Query: 314 EAAGSVRTEEVESR----AYADPCSRRKKRQQQEEEDLNLED----RGEETFRWWNQGSR 365
           E     + +  E +       +    ++++ Q++EE +  ++    + EE  R   +  R
Sbjct: 331 EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMR 390

Query: 366 EQSMQ 370
           +Q  Q
Sbjct: 391 KQEEQ 395



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 40/179 (22%), Positives = 92/179 (51%), Gaps = 20/179 (11%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
           Q++ + +  ++++++ R++EE+     E+ + +E+  E  EQ   + ++++ R QE ++ 
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ--MREQEEQMREQEEQMR 313

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
           ++ E   +  E+E+  G         +EQ  +     +K++ W  +EE+MG  EE  + +
Sbjct: 314 EQEE---QMREQEEQMGKQEEQMWEQKEQMWE-----QKEQMW-KQEEQMGEQEEQMQKQ 364

Query: 314 EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDL--NLEDRGEETFRWWNQGSREQSMQ 370
           E    VR +E + R   +   +++++ +++EE +    E  GE+      +  REQ  Q
Sbjct: 365 EE--QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ-----KEQMREQEEQ 416



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 38/199 (19%), Positives = 93/199 (46%), Gaps = 30/199 (15%)

Query: 177 QEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDAD-EKHPEHAEQ 235
           +++  +   +GQ     +   E +   +K++++  ++EE+    E    + E+  +  E+
Sbjct: 189 EQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE 248

Query: 236 NIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKR 295
            ++K +++ R+ +E      RE   +  E+E+         L  +EQT Q  + G+++++
Sbjct: 249 QVQKQEEQMRKQEE----QMREQEEQMREQEEQM-------LKQKEQTEQEEQTGEQEEQ 297

Query: 296 WHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
              +EE+M   EE          +R +E + R   +   +++++  +++E +      E+
Sbjct: 298 MREQEEQMREQEE---------QMREQEEQMREQEEQMGKQEEQMWEQKEQM-----WEQ 343

Query: 356 TFRWWNQ----GSREQSMQ 370
             + W Q    G +E+ MQ
Sbjct: 344 KEQMWKQEEQMGEQEEQMQ 362



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 35/167 (20%), Positives = 80/167 (47%), Gaps = 6/167 (3%)

Query: 205 KKKKRRQKEEEEATASERNDADEKHPEHAEQNIR-KSKKKKRRHQEGKVSDEREGTTKGN 263
           ++++ + +E+E     +     E+  +  EQ  + + ++ + R QEG+V  E+EG  +  
Sbjct: 125 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQ 183

Query: 264 EKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEE 323
           E +       +GE    +   Q  + G+++++   +EE+MG  EE  + +E     + E+
Sbjct: 184 EGQVREQEGQMGEQEG-QMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242

Query: 324 V---ESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
           V   E +        RK+ +Q  E++  + ++ E+  +   Q  +E+
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 29/164 (17%), Positives = 72/164 (43%), Gaps = 3/164 (1%)

Query: 145 DEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKK 204
           ++ML Q  +     +       M+ +  ++  QE+    + +       Q+  + +   +
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335

Query: 205 KKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNE 264
           +K++  +++E+     E+    E+  +  E+ +RK +++ R+ +E     E +   +  +
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ 395

Query: 265 KEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEE 308
             +     G  +   REQ  Q    G++K++   +EE MG  +E
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQ---MGEQKEQMRKQEEHMGEQKE 436



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 34/169 (20%), Positives = 77/169 (45%), Gaps = 20/169 (11%)

Query: 205 KKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNE 264
           ++++ + +E+E     +     E+  +  EQ      + +   QE ++ ++ E   K  E
Sbjct: 167 REQEGQVREQEGQVREQEGQVREQEGQMGEQ------EGQMGEQEEQMGEQEEQMQKQEE 220

Query: 265 KEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEV 324
           +        +GE    +   Q  + G+++++   +EE++   EE  + +E    +R +E 
Sbjct: 221 Q--------MGE-QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE--QMREQEE 269

Query: 325 ESRAYADPCSRRKKRQQQEEEDLNLEDR---GEETFRWWNQGSREQSMQ 370
           + R   +   ++K++ +QEE+    E++    EE  R   +  REQ  Q
Sbjct: 270 QMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQ 318


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 34/174 (19%), Positives = 80/174 (45%), Gaps = 7/174 (4%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           R +  D    + +S  K   +++++ R++E E     ER    E+  E   +  R+  KK
Sbjct: 371 RERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKK 430

Query: 244 KRRHQEGKVSDEREGTTKGNEKEDAAGTSGL--GELNSREQTNQSLRKGKKKKRWHHEEE 301
           + R ++ + + ER    +   +++AA    L   E+  R++T +  ++ +++     EE 
Sbjct: 431 RDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAERE-----EER 485

Query: 302 KMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
           +  + +E  + KE       +  + + Y     +++ R +++E + +  DR  E
Sbjct: 486 RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKRE 539



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 32/155 (20%), Positives = 62/155 (40%), Gaps = 3/155 (1%)

Query: 198 ESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDERE 257
           E K  K+K+++  +KE  E       + + +  E   +  R+ +K+K R +E +   +R+
Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352

Query: 258 GTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAG 317
            T + +   D           S ++     R  +K +    E E+     E  + +E   
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE---RERERERERER 409

Query: 318 SVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
               E    R       + KKR ++E+E+   E R
Sbjct: 410 EREREREREREREREREKDKKRDREEDEEDAYERR 444



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/157 (19%), Positives = 67/157 (42%), Gaps = 7/157 (4%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDE 255
           + E +  ++++++ R++E E     E+    E+  E      R  ++ + R +E     +
Sbjct: 311 ERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRD 370

Query: 256 REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEA 315
           RE ++  N+    +          RE+  +  R+ ++++    E E+     E  + +E 
Sbjct: 371 RERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE---REREREREK 427

Query: 316 AGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR 352
                 EE E  AY     RRK  ++  E++   ++R
Sbjct: 428 DKKRDREEDEEDAY----ERRKLERKLREKEAAYQER 460



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 34/179 (18%), Positives = 68/179 (37%), Gaps = 9/179 (5%)

Query: 168 KAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADE 227
           K K    E +      R K +D    + +   +  ++   + + +      + +R    E
Sbjct: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396

Query: 228 KHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSL 287
           +  E   +  R+ ++++ R +E +   ERE   K + +ED        +L          
Sbjct: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE--------- 447

Query: 288 RKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEED 346
           RK ++K+  + E  K   + E  K +E       EE   R  A    R K+  +  ++D
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 43/205 (20%), Positives = 74/205 (36%), Gaps = 32/205 (15%)

Query: 182 LARLKGQDPGAPQLQSESKPPKKKKKKRRQ-----------------KEEEEATASERND 224
           L R    +  AP  +S+S P KKKK+K+                   KE+  A   E + 
Sbjct: 214 LIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDK 273

Query: 225 AD----------EKHPEHAEQNIRKSKK-----KKRRHQEGKVSDEREGTTKGNEKEDAA 269
            D          + H +  E+  +K K+     K+RR +E +   ERE   +  E+E   
Sbjct: 274 RDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERER 333

Query: 270 GTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAY 329
                 E     + ++   + K++ R    E       E    +    S   E+   R  
Sbjct: 334 EREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRER 393

Query: 330 ADPCSRRKKRQQQEEEDLNLEDRGE 354
                R ++R+++ E +   E   E
Sbjct: 394 ERERERERERERERERERERERERE 418



 Score = 36.2 bits (82), Expect = 0.048
 Identities = 39/182 (21%), Positives = 75/182 (41%), Gaps = 17/182 (9%)

Query: 203 KKKKKKRRQKEEEEATASERNDAD----EKHPEHAEQ----NIRKSKKKKRRHQEGKVSD 254
           +++K K+R +EE+E  A ER   +    EK   + E+     IR+ KK +   +E +  +
Sbjct: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483

Query: 255 EREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKE 314
           ER    +   KE       L + +      +  R    +KR    E++M   E   K ++
Sbjct: 484 ERR---REMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540

Query: 315 AAGSVRTEEVESRAYADPCSRRKKRQQQEEE------DLNLEDRGEETFRWWNQGSREQS 368
                  + + +  + DP +  ++ +Q+ E           E   EE  +   +  RE+ 
Sbjct: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600

Query: 369 MQ 370
           M+
Sbjct: 601 ME 602



 Score = 35.8 bits (81), Expect = 0.063
 Identities = 36/169 (21%), Positives = 69/169 (40%), Gaps = 23/169 (13%)

Query: 203 KKKKKKRRQKEEEEATASERNDAD-----------EKHPEHAEQNIRKSKKKKRRHQEGK 251
           ++++++R +++E+E       D D           ++  +      R S + K R +  +
Sbjct: 327 REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386

Query: 252 VSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGV-----L 306
            S +RE   +   + +            RE+  +  R+ +K K+   EE++        L
Sbjct: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKL 446

Query: 307 EEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
           E   + KEAA   R +  E R        RKK ++ E+E    E+R  E
Sbjct: 447 ERKLREKEAAYQERLKNWEIR-------ERKKTREYEKEAEREEERRRE 488



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 19/75 (25%), Positives = 34/75 (45%), Gaps = 1/75 (1%)

Query: 168 KAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADE 227
           K +   LE   Q  LA     DP A   + E +  ++++ + +Q+ E E    E+ + +E
Sbjct: 537 KREKEELEEIRQRLLAE-GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEE 595

Query: 228 KHPEHAEQNIRKSKK 242
           K  E  E+     +K
Sbjct: 596 KREEPMEEEEEPEQK 610


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 43/210 (20%), Positives = 99/210 (47%), Gaps = 24/210 (11%)

Query: 167 MKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDAD 226
           ++ +  ++  QE+    + K       +L+ + K  +++K+ R Q+E+ +    +  + +
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361

Query: 227 EKHPEHAEQNIRKSKK-----KKRRHQEGKVSDEREGTTKGN----EKEDAAGTSGLGEL 277
           EK  E  E+  R+ ++     K+ R QE K+ D+ E   + +    EKE+         +
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE--------RM 413

Query: 278 NSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRK 337
             +E+  + + K +++K+   +E+K    EE  + +E    +R  E + R   +    ++
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE---RIREREKKMREEEETMREQE 470

Query: 338 KRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
           ++ Q++EE++  ++  E    W  Q   EQ
Sbjct: 471 EKMQKQEENMWEQEEKE----WQQQRLPEQ 496



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 42/204 (20%), Positives = 91/204 (44%), Gaps = 15/204 (7%)

Query: 167 MKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKK-KKKRRQKEEEEATASERNDA 225
           M+ +  ++  QE+    R+  QD    + +   +  +K  ++  + +EE++    E+   
Sbjct: 385 MREQEQKMRDQEE----RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440

Query: 226 DEKHPEHAEQNIRKSKKKKR------RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNS 279
           D++     E+ IR+ +KK R      R QE K+  + E   +  EKE       L E   
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKE 498

Query: 280 REQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKR 339
           +    + +++ +++K W  EE+     E  G+ K+     +  E E + +      R + 
Sbjct: 499 KLWEQEKMQE-QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557

Query: 340 QQQEEEDLNLEDR-GEETFRWWNQ 362
           Q+  +++  +E +  E+  + W+Q
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQ 581



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 46/183 (25%), Positives = 88/183 (48%), Gaps = 22/183 (12%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           RL+ ++    + +   +  +K +++++ +E+E+ T     D +EK  E  E+ IR+ +KK
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT----RDQEEKMQE--EERIREREKK 458

Query: 244 KRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKM 303
            R         E E T +  E++       + E   +E   Q L + +K+K W  E+EKM
Sbjct: 459 MR---------EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE-QKEKLW--EQEKM 506

Query: 304 GVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR-GEETFRWWNQ 362
              EE  K  E    +R +E E         R++K ++QE++    E++  ++  + W+Q
Sbjct: 507 QEQEE--KIWEQEEKIRDQE-EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563

Query: 363 GSR 365
             R
Sbjct: 564 EER 566



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 40/197 (20%), Positives = 88/197 (44%), Gaps = 22/197 (11%)

Query: 184 RLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK 243
           +++ Q+    + + + +  ++K   + ++ E++    E+   D++     E+ +R+ +KK
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK 597

Query: 244 KR------RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWH 297
            R      R QE K+ ++ E   +  EK        + E   + Q  +     +++K W 
Sbjct: 598 MREEEEMMREQEEKMQEQEEKMQEQEEK--------MWEQEEKMQEQEEKMWEQEEKMWE 649

Query: 298 HEE---EKMGVLEEGGK---GKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED 351
            EE   E+  + E+  K    ++     + +E E + +       KK Q+QE++  + E 
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE-KMEKKTQEQEKKTWDQEK 708

Query: 352 -RGEETFRWWNQGSREQ 367
            R EE+ R   +  RE+
Sbjct: 709 MREEESMREREKKMREE 725



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 35/162 (21%), Positives = 76/162 (46%), Gaps = 9/162 (5%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVS 253
           ++  E +   ++++++ Q++EEE    E    +++     +Q + + K+K   H++    
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK---M 783

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
            E+E   +  EK         G+        + +R G+++K W  +EEKM   EE   G+
Sbjct: 784 QEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR-GQEEKMWG-QEEKMWGQEEKMWGQ 841

Query: 314 EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEE 355
           E     + E++E +       + +K ++QEE+    E++  E
Sbjct: 842 EEKMWGQEEKMEEKMQ----GQEEKMREQEEKMRGQEEKMRE 879



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/205 (21%), Positives = 92/205 (44%), Gaps = 22/205 (10%)

Query: 167 MKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDAD 226
           M+ +  ++  QE+    + + Q+      + + +  ++ +++ ++  EEE    E+   +
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ---E 609

Query: 227 EKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQS 286
           EK  E  E+   + +++K   QE K+ ++ E   +  EK        + E   +    Q 
Sbjct: 610 EKMQEQEEK--MQEQEEKMWEQEEKMQEQEEKMWEQEEK--------MWEQEEKMWEQQR 659

Query: 287 LRKGKKKKRWHH----EEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQ 342
           L + +K+K W H    E+EKM   EE    +E     +T+E E + +     R ++  ++
Sbjct: 660 LPE-QKEKLWEHEKMQEQEKMQEQEEKIWEQEKM-EKKTQEQEKKTWDQEKMREEESMRE 717

Query: 343 EEEDLNLEDRGEETFRWWNQGSREQ 367
            E+ +  E   EE  R   +  +EQ
Sbjct: 718 REKKMREE---EEMMREQEEKMQEQ 739



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 38/178 (21%), Positives = 78/178 (43%), Gaps = 36/178 (20%)

Query: 198 ESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDERE 257
           E +  ++++KK R++EE                      + + +++K + QE K+ ++ E
Sbjct: 711 EEESMREREKKMREEEE----------------------MMREQEEKMQEQEEKMQEQEE 748

Query: 258 GTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHE--EEKMGVLEEGGKGKEA 315
              +  EK        + E   +    Q L + +K+K W HE  +E+  + E+  K ++ 
Sbjct: 749 EMWEQEEK--------MWEQEEKMWEQQRLPE-QKEKLWEHEKMQEQEKIWEQEEKMRDQ 799

Query: 316 AGSVRTEEVESRAYADPC-SRRKKRQQQEEEDLNLEDR--GEETFRWWNQGSREQSMQ 370
              +R +E + R   +    + +K   QEE+    E++  G+E   W  +   E+ MQ
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 39/171 (22%), Positives = 82/171 (47%), Gaps = 16/171 (9%)

Query: 203 KKKKKKRRQKEEEEATASER-NDADEKHPEHAEQNIRKSKK-----KKRRHQEGKVSDER 256
           ++++KK R++EE+     ER  + + K  E  E+  R+ K+     K+ R QE ++ +++
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341

Query: 257 EGTTKGNEKEDAAGTSGLGELNSREQT----NQSLRKGKKKKRWHHEEEKM-----GVLE 307
           E   +  + ++        E   REQ      Q  R  +++K+   +E+KM      + E
Sbjct: 342 ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFR 358
           +  + +E    +R +E +     +     KK Q+QE++  + E++ +E  R
Sbjct: 402 QDERLREKEERMREQE-KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 38/182 (20%), Positives = 82/182 (45%), Gaps = 14/182 (7%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRR--HQEGK 251
           ++  + K   +++K R Q+++      +  D ++K  +  E+  +K+++++++   QE K
Sbjct: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584

Query: 252 VSDE---REGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEE 308
           + +E   RE   K  E+E+      + E   + Q  +   + +++K W  +EEKM   EE
Sbjct: 585 MREEERMREREKKMREEEEM-----MREQEEKMQEQEEKMQEQEEKMW-EQEEKMQEQEE 638

Query: 309 GGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQS 368
               +E       E+ E          +K++  + E+    E   E+  + W Q   E+ 
Sbjct: 639 KMWEQE---EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695

Query: 369 MQ 370
            Q
Sbjct: 696 TQ 697



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 39/177 (22%), Positives = 80/177 (45%), Gaps = 28/177 (15%)

Query: 194 QLQSESKPPKKKKKKRRQKEEEEATASERN-DADEKHPEHAE-----QNIRKSKKKKRRH 247
           ++Q + +  +++++K  ++EE+     E+  + +EK  E  E     Q + + K+K   H
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670

Query: 248 QEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           ++     E+E   +  EK        + E    E+  Q     ++KK W  ++EKM    
Sbjct: 671 EK---MQEQEKMQEQEEK--------IWEQEKMEKKTQE----QEKKTW--DQEKM---R 710

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDL--NLEDRGEETFRWWNQ 362
           E    +E    +R EE   R   +    ++++ Q++EE++    E   E+  + W Q
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 46/201 (22%), Positives = 94/201 (46%), Gaps = 16/201 (7%)

Query: 177 QEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQN 236
           +E+    + K Q+  A   + E K  ++++K R Q+E  +    +  + +EK  E  E+ 
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE- 426

Query: 237 IRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGK---KK 293
             + +++K R QE K+   RE   K  E+E+        E+   ++     ++GK   ++
Sbjct: 427 -MQEQEEKMRRQEEKI---REQEKKIREQEEKIREQ--EEMMQEQEEKMGEQEGKMCEQE 480

Query: 294 KRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED-- 351
            +   +EEKM   EE  K +E    +R +E + R   +    ++++  ++EE +  ++  
Sbjct: 481 AKMQEQEEKMRRQEE--KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 538

Query: 352 --RGEETFRWWNQGSREQSMQ 370
               EE  R   +  REQ ++
Sbjct: 539 MQEQEEKMRRQEEKMREQEVR 559



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 41/177 (23%), Positives = 77/177 (43%), Gaps = 25/177 (14%)

Query: 203 KKKKKKRRQ------KEEEEATASERNDADEKHPEHAEQNIRKSK---KKKRRHQEGKVS 253
           +K++K RRQ      KEE+     E+    EK  E  E+   + K   ++KR+ QE K+ 
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 386

Query: 254 DEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGK 313
            + E   +  EK        + E     Q  +     +++K W  EEE   + E+  K +
Sbjct: 387 RQEEKIREQEEK--------IREQEEMMQEQEEKMGEQEEKMWEQEEE---MQEQEEKMR 435

Query: 314 EAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
                +R +E + R   +    +++  Q++EE +     GE+  +   Q ++ Q  +
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM-----GEQEGKMCEQEAKMQEQE 487



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 41/192 (21%), Positives = 87/192 (45%), Gaps = 21/192 (10%)

Query: 198 ESKPPKKKKKKRRQKEEEEATASERNDADEKHPE--HAEQNIRKSKKKKR------RHQE 249
           E    ++K +++ +K +EE    E+    E+  +    E+ IR+ ++K R      + QE
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQE 410

Query: 250 GKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHE-----EEKMG 304
            K+ ++ E   +  E+          +     +  + +R+ ++K R   E     EEKMG
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG 470

Query: 305 VLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDR--GEETFRWWNQ 362
             E+ GK  E    ++ +E + R   +    ++K+ +++EE +  ++    E+  + W Q
Sbjct: 471 --EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 528

Query: 363 GSR----EQSMQ 370
             +    E+ MQ
Sbjct: 529 EEKMCEQEEKMQ 540



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 42/176 (23%), Positives = 81/176 (46%), Gaps = 29/176 (16%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQ----KEEEEATASERNDADEKHP 230
           E +E+ +    + Q+      + E K  +++KK R Q    +E+EE    +     E+  
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEG 474

Query: 231 EHAEQNIR-KSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRK 289
           +  EQ  + + +++K R QE K+   RE   K  E+E+            REQ  + + +
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKI---REQEKKIREQEE----------KIREQ--EEMMQ 519

Query: 290 GKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEE 345
            +++K W  EE+   + E+  K +E    +R +E + R       +  + +QQEE+
Sbjct: 520 EQEEKMWEQEEK---MCEQEEKMQEQEEKMRRQEEKMR------EQEVRLRQQEEK 566


>gi|118600973 RNA binding motif protein, X-linked 2 [Homo sapiens]
          Length = 322

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 42/173 (24%), Positives = 71/173 (41%), Gaps = 11/173 (6%)

Query: 188 QDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRH 247
           +D    +   + K  KKKKKK ++K + E  A + + +  +     E++    KK   ++
Sbjct: 150 EDEKPTKKHKKDKKEKKKKKKEKEKADREVQAEQPSSSSPRRKTVKEKDDTGPKKHSSKN 209

Query: 248 QE-GKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVL 306
            E  + S+ REG  +   K   A + G  +L    +  +   + K   R    EEK  + 
Sbjct: 210 SERAQKSEPREG--QKLPKSRTAYSGGAEDLERELKKEKPKHEHKSSSRREAREEKTRI- 266

Query: 307 EEGGKGKEAAGSVRTEEVESRAYADPCSRRKK-------RQQQEEEDLNLEDR 352
            + G+  +A  S      E R+Y      R K       R+ +E E  N  DR
Sbjct: 267 RDRGRSSDAHSSWYNGRSEGRSYRSRSRSRDKSHRHKRARRSRERESSNPSDR 319


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 38/177 (21%), Positives = 85/177 (48%), Gaps = 23/177 (12%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRR-----HQEG 250
           Q E +  ++K +++ +++E+EA    +    E+     E+ IR+ +KK  R     H++ 
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQ----EEKIREQEEKIREQEKKMWRQEEKIHEQE 464

Query: 251 KVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGG 310
           K+ +E     K  E+E+             E+ ++     ++K++ H +EEK+   EE  
Sbjct: 465 KIREEE----KRQEQEEM--------WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE-- 510

Query: 311 KGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQ 367
           K       +R +E + R   +   R++++ +++EE    E++  E  + W +  R++
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 47/203 (23%), Positives = 89/203 (43%), Gaps = 36/203 (17%)

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKK-- 243
           K Q+      + E K  ++++K  RQ+E+      +R + +EK  +  E+ IR+ ++K  
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ-EEKIREQEEKIQ 622

Query: 244 ----KRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHE 299
               K R QE K+ ++ E T +  EK        +GE   +    +   + +++  W  E
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEK--------MGEQEEKMCEQEEKMQEQEETMWRQE 674

Query: 300 EEKMGVLEEGGKGKEAAGSVRTEEVESRAYADP--------CSRRKKRQQQEEEDLNLED 351
           E+   + E+  K +E    +R +E   +   +         C + +K Q+QEE+    E+
Sbjct: 675 EK---IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731

Query: 352 RGEETFRWWNQGSR----EQSMQ 370
                 + W Q  R    E+ MQ
Sbjct: 732 ------KMWEQEVRLRQQEEKMQ 748



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 54/249 (21%), Positives = 104/249 (41%), Gaps = 36/249 (14%)

Query: 141 KILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQ---------------EQAFLARL 185
           K+L  +  LQA       +A  LG  +++  A+L+AQ               E+ +    
Sbjct: 255 KLLLPQQQLQA-------EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 307

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKR 245
           K Q+      + E K  ++++K R Q+E+         + +EK     E    K +K +R
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 246 RHQ-----EGKVSDEREGTTKGNEK--EDAAGTSGLGELNSREQTNQSLRKGKKKKRWHH 298
           + +     E K+  + E   +  EK  E         ++  +E+  Q   K +++++   
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427

Query: 299 EEEKMGVLEEGGKGKEAAGSVRTEE-----VESRAYADPCSRRKKRQQQEEEDLNLEDRG 353
           +E KM   EE  K +E    +R +E      E + +     R ++++Q++EE    E++ 
Sbjct: 428 QEAKMWRQEE--KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485

Query: 354 EETFRWWNQ 362
            E    W Q
Sbjct: 486 HEQEEIWRQ 494



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 35/148 (23%), Positives = 74/148 (50%), Gaps = 8/148 (5%)

Query: 205 KKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNE 264
           +++KR+++E++     E+    E+     E+ IR+ +++KR+ QE K+  + E   +  E
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE-QEEKRQEQEEKMWKQEEKIREQEE 619

Query: 265 K-EDAAGTSGLGELNSREQ----TNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSV 319
           K ++        E   REQ      Q  + G+++++   +EEKM   EE    +E    +
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE--KI 677

Query: 320 RTEEVESRAYADPCSRRKKRQQQEEEDL 347
           R +E + R   +    +++  Q++EE +
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKM 705



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 37/178 (20%), Positives = 81/178 (45%), Gaps = 16/178 (8%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E +E+ +    K ++    + + E K  K+++K R Q+E+ +    +  + +EK  E  E
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640

Query: 235 QNIRKSKK-----KKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRK 289
               + +K     +K   QE K+ ++ E T    E++       + E   + +  + + +
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEE-TMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699

Query: 290 GKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDL 347
            +++K W  +EEKM   EE          ++ +E + R   +    ++ R +Q+EE +
Sbjct: 700 EQEEKMW-EQEEKMCEQEE---------KMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 747



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 45/209 (21%), Positives = 96/209 (45%), Gaps = 29/209 (13%)

Query: 177 QEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASER-NDADEKHPEHAEQ 235
           QEQ  + R + +     ++  + +   ++++K R++EE+     E+  + +EK  E  E+
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532

Query: 236 NIRKSKK----------KKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQ 285
             R+ +K          +++ H++ K+ +E     K  E+ED        E   REQ  +
Sbjct: 533 MWRQEEKIREQEEMWREEEKMHEQEKIWEEE----KRQEQEDKMWRQ---EEKIREQEEK 585

Query: 286 SLRKGKK----KKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQ 341
             R+ +K    +++   +EEKM   EE  K +E    ++ +E + R   +    +++  Q
Sbjct: 586 VWRQEEKIREQEEKRQEQEEKMWKQEE--KIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643

Query: 342 QEEEDLNLEDRGEETFRWWNQGSREQSMQ 370
           ++EE +     GE+  +   Q  + Q  +
Sbjct: 644 EQEEKM-----GEQEEKMCEQEEKMQEQE 667


>gi|33356179 transcription termination factor, RNA polymerase I
           [Homo sapiens]
          Length = 905

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 49/215 (22%), Positives = 88/215 (40%), Gaps = 36/215 (16%)

Query: 165 ITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERND 224
           ++++ KL R + +   F    K     +  L S+ +  K KK +R+    E   A +   
Sbjct: 130 MSIEQKLPR-KPKTDKFQVLAKSHAHKSEALHSKVREKKNKKHQRKAASWESQRARDTLP 188

Query: 225 ADEKH-----------------PEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEK-- 265
             E H                 P  A +N  K KKKK  ++E +     EG+  G E   
Sbjct: 189 QSESHQEESWLSVGPGGEITELPASAHKNKSKKKKKKSSNREYETLAMPEGSQAGREAGT 248

Query: 266 --EDAAGTSGLGELNSR--EQTNQSLRKGKKKKRWHHEEEKMGVLEEGGK-GKEAAGSVR 320
             +++  T GL +   +    T++   K KKKK+ +H+E +   + EG + G E    ++
Sbjct: 249 DMQESQPTVGLDDETPQLLGPTHKKKSKKKKKKKSNHQEFEALAMPEGSQVGSEVGADMQ 308

Query: 321 -----------TEEVESRAYADPCSRRKKRQQQEE 344
                      T  + + AY +   ++KK+   +E
Sbjct: 309 ESRPAVGLHGETAGIPAPAYKNKSKKKKKKSNHQE 343



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 38/139 (27%), Positives = 55/139 (39%), Gaps = 34/139 (24%)

Query: 187 GQDPGAPQLQSESKPPKKKKKKRRQKEEEE-----------------ATASERNDADEKH 229
           G D   PQL   +   K KKKK+++   +E                 A   E   A   H
Sbjct: 258 GLDDETPQLLGPTHKKKSKKKKKKKSNHQEFEALAMPEGSQVGSEVGADMQESRPAVGLH 317

Query: 230 ------PEHAEQNIRKSKKKKRRHQEGKV--------SDEREGTTKGNEKEDAAGTSGLG 275
                 P  A +N  K KKKK  HQE +         S   EG+  G+E     G++   
Sbjct: 318 GETAGIPAPAYKNKSKKKKKKSNHQEFEAVAMPESLESAYPEGSQVGSEVGTVEGSTA-- 375

Query: 276 ELNSREQTNQSLRKGKKKK 294
            L   +++N + +K KK+K
Sbjct: 376 -LKGFKESNSTKKKSKKRK 393



 Score = 32.0 bits (71), Expect = 0.91
 Identities = 40/219 (18%), Positives = 87/219 (39%), Gaps = 31/219 (14%)

Query: 156 TAHKAARLGITMKAKLARLEAQEQAFLARL---------------KGQDPGAPQLQSESK 200
           TA+  + L    K + + LE  E+A +  +               K  D     +  E K
Sbjct: 76  TANATSTLKKRKKRRYSALEVDEEAGVTVVLVDKENINNTPKHFRKDVDVVCVDMSIEQK 135

Query: 201 PPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGT- 259
            P+K K  + Q          ++ A +    H++   +K+KK +R+    +    R+   
Sbjct: 136 LPRKPKTDKFQ-------VLAKSHAHKSEALHSKVREKKNKKHQRKAASWESQRARDTLP 188

Query: 260 -TKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGS 318
            ++ +++E        GE+     +    +  KKKK+  + E +   + EG +    AG+
Sbjct: 189 QSESHQEESWLSVGPGGEITELPASAHKNKSKKKKKKSSNREYETLAMPEGSQAGREAGT 248

Query: 319 VRTE-------EVESRAYADPCSRRKKRQQQEEEDLNLE 350
              E       + E+     P  ++K +++++++  + E
Sbjct: 249 DMQESQPTVGLDDETPQLLGPTHKKKSKKKKKKKSNHQE 287



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 27/134 (20%), Positives = 52/134 (38%), Gaps = 17/134 (12%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           + QE      L G+  G P    ++K  KKKKK   Q+ E  A       A   +PE ++
Sbjct: 306 DMQESRPAVGLHGETAGIPAPAYKNKSKKKKKKSNHQEFEAVAMPESLESA---YPEGSQ 362

Query: 235 --------------QNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSR 280
                         +  ++S   K++ ++ K++  +     G++    +  S     +S 
Sbjct: 363 VGSEVGTVEGSTALKGFKESNSTKKKSKKRKLTSVKRARVSGDDFSVPSKNSESTLFDSV 422

Query: 281 EQTNQSLRKGKKKK 294
           E     + +G K +
Sbjct: 423 EGDGAMMEEGVKSR 436


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 41/202 (20%), Positives = 92/202 (45%), Gaps = 31/202 (15%)

Query: 168 KAKLARLEAQEQAFL------------ARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEE 215
           +A+ ARLEA+E+  +            AR++ ++  A Q     +  ++ +++ R +EEE
Sbjct: 266 EAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ----ERERREAEERERMREEE 321

Query: 216 EATASERNDADEKHPEHAEQNIR-KSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGL 274
           +  A ER    E+    AE+  R K ++K+   +  ++ +E +   +  ++         
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR--------- 372

Query: 275 GELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEV-ESRAYADPC 333
               +R +  +  +  ++K+    EE+K  + E   KG++    +  + V E +A  D  
Sbjct: 373 ----ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL 428

Query: 334 SRRKKRQQQEEEDLNLEDRGEE 355
                ++Q EE+   ++ + E+
Sbjct: 429 QTAVLKKQGEEKGTKVQAKREK 450



 Score = 42.0 bits (97), Expect = 9e-04
 Identities = 52/209 (24%), Positives = 89/209 (42%), Gaps = 16/209 (7%)

Query: 126 LESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARL 185
           LE+   +  +  +  KI  +   ++A E   A +  R     + ++   E +      R+
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331

Query: 186 KGQDPGAPQLQSESKPPKKKKKKRRQ--KEEEEATASERNDADEKHPEHAEQNIRKSKK- 242
           K ++  A + +   K  +K+  + RQ  KEEE+  A ER  A  +  E A+   +K  K 
Sbjct: 332 KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391

Query: 243 ---KKRRHQEGKVSDER-EGTTKG---NEK---EDAAGTSGLGELNSREQTNQSLRKGK- 291
              KK   QE K+  E+ E   +G   NEK   ED   T+ L +    + T    ++ K 
Sbjct: 392 LEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKL 451

Query: 292 --KKKRWHHEEEKMGVLEEGGKGKEAAGS 318
              K  +  EE K   +++  + KE   S
Sbjct: 452 QEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 38/172 (22%), Positives = 74/172 (43%), Gaps = 15/172 (8%)

Query: 196 QSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQE----GK 251
           ++E+   ++K + R+++ E E T +      +     AE+N ++ K+K+   +E    G 
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 202

Query: 252 VSDER-----EGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHH---EEEKM 303
           + + +     E  T  +++E    +   G+++S E   +  R+    +  HH   EEE  
Sbjct: 203 IGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDK 262

Query: 304 GVLEEGGKGKEAAGSVRTEEVESRAYADPCSR---RKKRQQQEEEDLNLEDR 352
              E      EA    R +  + +  AD  +R    +K   QE E    E+R
Sbjct: 263 ERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 40/184 (21%), Positives = 83/184 (45%), Gaps = 31/184 (16%)

Query: 175 EAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAE 234
           E+QE+  +  LK       Q+ SE    + K+++ R++  +E +  E+ + ++K    AE
Sbjct: 218 ESQEETVVMSLKNG-----QISSE----EPKQEEEREQGSDEISHHEKMEEEDKERAEAE 268

Query: 235 QNIRKSKKKKR--RHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKK 292
           +   ++++++R    Q+ K++DER       E E+ A          RE+     R+ ++
Sbjct: 269 RARLEAEERERIKAEQDKKIADERARI----EAEEKAAAQ------ERER-----REAEE 313

Query: 293 KKRWHHE-----EEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDL 347
           ++R   E     EE+  + EE  +  E    ++ EE  +          +KR  +E +  
Sbjct: 314 RERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRA 373

Query: 348 NLED 351
             E+
Sbjct: 374 RAEE 377



 Score = 35.8 bits (81), Expect = 0.063
 Identities = 33/164 (20%), Positives = 82/164 (50%), Gaps = 19/164 (11%)

Query: 203 KKKKKKRRQKEEE-----EATASERNDADEKHPEHAEQNIRKSKKKKRRHQE-----GKV 252
           +++++ RRQK EE     E  A +RND DE+  E A +  R++++++ R ++     G+V
Sbjct: 5   ERRRELRRQKREEMRLEAERIAYQRNDDDEE--EAARERRRRARQERLRQKQEEESLGQV 62

Query: 253 SDEREGTTKGNEKEDAAGTSGL-----GELNSREQTNQSLRKGKKKKRWHHEEEKMGVLE 307
           +D+ E   + +  ++ A T+       G+  +      + R+ +++KR     E+    E
Sbjct: 63  TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ--KE 120

Query: 308 EGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLED 351
                 +A+ S+ +  +++    +  + ++++ +  +E   +E+
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEE 164



 Score = 32.7 bits (73), Expect = 0.54
 Identities = 28/121 (23%), Positives = 54/121 (44%), Gaps = 4/121 (3%)

Query: 173 RLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEH 232
           R E + + F    + Q   A +L+      KKK+++RR+  EEE    ++ +AD K  E 
Sbjct: 543 RGETESEEFEKLKQKQQEAALELEEL----KKKREERRKVLEEEEQRRKQEEADRKLREE 598

Query: 233 AEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKK 292
            E+   K + ++RR +  +   +       ++K+     +  G     E+  + L K  +
Sbjct: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQ 658

Query: 293 K 293
           K
Sbjct: 659 K 659



 Score = 29.3 bits (64), Expect = 5.9
 Identities = 36/189 (19%), Positives = 69/189 (36%), Gaps = 12/189 (6%)

Query: 170 KLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKH 229
           +LAR E + Q  L     +        +++      ++ +    E E T  E      + 
Sbjct: 99  RLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQE 158

Query: 230 PEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLG----ELNSREQTNQ 285
               E+    +K  ++        +++E   K  E+E+      +G    E+   E+T +
Sbjct: 159 RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTE 218

Query: 286 SLRK----GKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQ 341
           S  +      K  +   EE K     E G  + +      EE + RA A+    R + + 
Sbjct: 219 SQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAE----RARLEA 274

Query: 342 QEEEDLNLE 350
           +E E +  E
Sbjct: 275 EERERIKAE 283


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.125    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,136,593
Number of Sequences: 37866
Number of extensions: 749941
Number of successful extensions: 13569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 389
Number of HSP's successfully gapped in prelim test: 601
Number of HSP's that attempted gapping in prelim test: 5911
Number of HSP's gapped (non-prelim): 4183
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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