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Search of human proteins with 33285015
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
(367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 746 0.0
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 105 8e-23
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 102 4e-22
gi|45827729 scribble isoform b [Homo sapiens] 102 7e-22
gi|45827731 scribble isoform a [Homo sapiens] 102 7e-22
gi|62241040 leucine rich repeat containing 8 family, member A [H... 100 2e-21
gi|187829877 leucine rich repeat containing 8 family, member A [... 100 2e-21
gi|187829871 leucine rich repeat containing 8 family, member A [... 100 2e-21
gi|40217803 leucine rich repeat containing 8 family, member E [H... 100 2e-21
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 98 1e-20
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 98 1e-20
gi|19923729 leucine rich repeat containing 8 family, member C [H... 97 2e-20
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 97 3e-20
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 97 3e-20
gi|61742786 leucine rich repeat and death domain containing prot... 96 7e-20
gi|61742784 leucine rich repeat and death domain containing prot... 96 7e-20
gi|197333706 leucine rich repeat containing 8 family, member D [... 91 2e-18
gi|34222199 leucine rich repeat containing 8 family, member D [H... 91 2e-18
gi|238908508 leucine-rich repeat and death domain-containing pro... 91 2e-18
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 89 5e-18
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 88 1e-17
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 87 2e-17
gi|197333692 leucine rich repeat containing 8 family, member B [... 87 2e-17
gi|21245134 leucine rich repeat containing 8 family, member B [H... 87 2e-17
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 87 2e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 86 5e-17
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 86 7e-17
gi|61742782 leucine rich repeat and death domain containing prot... 85 1e-16
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 85 1e-16
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 83 4e-16
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 746 bits (1926), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENL 60
MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENL
Sbjct: 1 MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENL 60
Query: 61 AQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLAN 120
AQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLAN
Sbjct: 61 AQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLAN 120
Query: 121 NQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
NQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP
Sbjct: 121 NQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
Query: 181 SLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVS 240
SLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVS
Sbjct: 181 SLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVS 240
Query: 241 EVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKDLNFLSPISL 300
EVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKDLNFLSPISL
Sbjct: 241 EVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQELAMRGLYHTYHSLLKDLNFLSPISL 300
Query: 301 PRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQWKTTVSFVAYCCSTQCL 360
PRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQWKTTVSFVAYCCSTQCL
Sbjct: 301 PRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQWKTTVSFVAYCCSTQCL 360
Query: 361 QTFDLLS 367
QTFDLLS
Sbjct: 361 QTFDLLS 367
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 105 bits (261), Expect = 8e-23
Identities = 80/254 (31%), Positives = 132/254 (51%), Gaps = 25/254 (9%)
Query: 10 SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVE 69
++A LE +NL L + P L + L+ LE L + N + +LPE++ L +L +
Sbjct: 152 NLASLELRENL------LTYLPDSLTQ---LRRLEELDLGNNEIYNLPESIGALL-HLKD 201
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
L+L N + +P+ IG+L L CLD+S+N LE + EI L +L L ++ N L+ +P
Sbjct: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG 261
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+G LK+L L + NRL LPE + C SL L + N+L +P+ + +L L+ L+
Sbjct: 262 IGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADR 321
Query: 190 NRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSS 249
N+L LP ++G L V +N L +P+ + Q +E+ +L +
Sbjct: 322 NKLVSLPKEIGGCCSLTVFCVRDN-RLTRIPAEV-------------SQATELHVLDV-A 366
Query: 250 GQRTVFLPAEVKAI 263
G R + LP + A+
Sbjct: 367 GNRLLHLPLSLTAL 380
Score = 88.6 bits (218), Expect = 8e-18
Identities = 81/293 (27%), Positives = 136/293 (46%), Gaps = 16/293 (5%)
Query: 41 QYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNAL 100
+++E + + SL +PE + + +L EL L +N + +PE LVKL+ L LSDN +
Sbjct: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
Query: 101 EIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
+ + PEI L L ++ N++ +P + K LQ D S N L LPE +L
Sbjct: 72 QRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
L+V+ L +P ++ L +L L + N L +LP L + R L+ + + NN + LP
Sbjct: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNN-EIYNLP 190
Query: 221 ----SYLYNKVIGCSG---CGAPIQVSEVK--LLSFSSGQRTVFLPAEVKAIGTEHDHVL 271
+ L+ K + G P ++ +K L S R LP E+ + + D V+
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
Query: 272 PLQELAMRGLYHTYHSLLKDLNFLSPISLPRSLLELLHCPLGHCHRCSEPMFT 324
+ L T + L LS + + ++ L L +G C +E + T
Sbjct: 251 ------SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLT 297
Score = 46.6 bits (109), Expect = 4e-05
Identities = 42/147 (28%), Positives = 70/147 (47%), Gaps = 7/147 (4%)
Query: 1 MASELCKTI--SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPE 58
++ L +TI + +L+K L ++ L P + + E L L + N L +LP+
Sbjct: 250 ISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT---ELVLTENQLLTLPK 306
Query: 59 NLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRL 118
++ KL L L N +V +P+ IG L + DN L + E+ + L L +
Sbjct: 307 SIG-KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDV 365
Query: 119 ANNQLQFLPPEVGDLKELQTLDISTNR 145
A N+L LP + LK L+ L +S N+
Sbjct: 366 AGNRLLHLPLSLTALK-LKALWLSDNQ 391
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 102 bits (255), Expect = 4e-22
Identities = 72/194 (37%), Positives = 108/194 (55%), Gaps = 3/194 (1%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L+ R L HFP + L + + + RN +PE Q L +L L L+ N +
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQ-LVSLEGLSLYHNCLRC 105
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
+ A+G+L L L+LS N L ++ P I +L LR L ++NN+L LPP++G L L+ L
Sbjct: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQL 164
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
D+S+N L +LP L SL+ L V RN+L +P L LP L L + NR++ +P+
Sbjct: 165 DVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSF 223
Query: 200 GRSRELQYVYVDNN 213
R R LQ + +D+N
Sbjct: 224 CRLRHLQVILLDSN 237
Score = 72.0 bits (175), Expect = 8e-13
Identities = 56/154 (36%), Positives = 79/154 (51%), Gaps = 5/154 (3%)
Query: 26 NLHHFPLELLKDE--GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEA 83
+L+H L L L L L + RN L+ LP + Q LP V L + +N + +P
Sbjct: 97 SLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQ-LPLRV-LIVSNNKLGALPPD 154
Query: 84 IGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
IG+L L+ LD+S N L+ + E+ L +LR L + NQL LP E+GDL L LD S
Sbjct: 155 IGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSC 213
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
NR+ +P LQ + +D N L P +C
Sbjct: 214 NRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVC 247
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 102 bits (253), Expect = 7e-22
Identities = 64/171 (37%), Positives = 95/171 (55%), Gaps = 1/171 (0%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
LE+L + N L LP+ L LPNL EL+L N + +P +G+L +L CLD+S+N LE
Sbjct: 176 LEQLDLGGNDLEVLPDTLGA-LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
+ E+G L L L L+ N L+ LP +G LK+L L + NRL + E + C +L L
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 163 TVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ N L +PR L +L L L++ N L LP ++G L + + +N
Sbjct: 295 ILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Score = 101 bits (251), Expect = 1e-21
Identities = 81/215 (37%), Positives = 108/215 (50%), Gaps = 27/215 (12%)
Query: 31 PLELLKD--EGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLV 88
PL L D L+ L L + SL +LP ++ L NLV L L N + +P ++ LV
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGN-LANLVTLELRENLLKSLPASLSFLV 174
Query: 89 KLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLT 148
KL+ LDL N LE++ +G L LR L L NQL LPPE+G+L+ L LD+S NRL
Sbjct: 175 KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 149 LPERL-------HMCLS----------------LQYLTVDRNRLWYVPRHLCQLPSLNEL 185
LP L + LS L L VD+NRL V + +L+EL
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 186 SMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
+ N L LP LG+ +L + VD N HL+ LP
Sbjct: 295 ILTENLLMALPRSLGKLTKLTNLNVDRN-HLEALP 328
Score = 94.4 bits (233), Expect = 1e-19
Identities = 72/211 (34%), Positives = 107/211 (50%), Gaps = 5/211 (2%)
Query: 18 KNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
+ L L+ L P + L L +L + N + LP +A + LVEL + N+I
Sbjct: 39 EELLLDANQLRELPKPFFR---LLNLRKLGLSDNEIQRLPPEVANFM-QLVELDVSRNDI 94
Query: 78 VVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQ 137
+PE+I L+ D S N L + +LR+L HL L + LQ LP +VG+L L
Sbjct: 95 PEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLV 154
Query: 138 TLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPL 197
TL++ N L +LP L + L+ L + N L +P L LP+L EL + N+L+ LP
Sbjct: 155 TLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPP 214
Query: 198 DLGRSRELQYVYVDNNIHLKGLPSYLYNKVI 228
+LG R L + V N L+ LP+ L V+
Sbjct: 215 ELGNLRRLVCLDVSEN-RLEELPAELGGLVL 244
Score = 76.6 bits (187), Expect = 3e-14
Identities = 60/172 (34%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L ++ L P EL GL L L + +N L LP+ + Q L L L + N +
Sbjct: 225 LDVSENRLEELPAEL---GGLVLLTDLLLSQNLLRRLPDGIGQ-LKQLSILKVDQNRLCE 280
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
V EAIG L L L++N L + +G+L L +L + N L+ LPPE+G L L
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNR 191
+ NRL LP L L L V NRL +P L L +L L +A N+
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 102 bits (253), Expect = 7e-22
Identities = 64/171 (37%), Positives = 95/171 (55%), Gaps = 1/171 (0%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
LE+L + N L LP+ L LPNL EL+L N + +P +G+L +L CLD+S+N LE
Sbjct: 176 LEQLDLGGNDLEVLPDTLGA-LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
+ E+G L L L L+ N L+ LP +G LK+L L + NRL + E + C +L L
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 163 TVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ N L +PR L +L L L++ N L LP ++G L + + +N
Sbjct: 295 ILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Score = 101 bits (251), Expect = 1e-21
Identities = 81/215 (37%), Positives = 108/215 (50%), Gaps = 27/215 (12%)
Query: 31 PLELLKD--EGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLV 88
PL L D L+ L L + SL +LP ++ L NLV L L N + +P ++ LV
Sbjct: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGN-LANLVTLELRENLLKSLPASLSFLV 174
Query: 89 KLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLT 148
KL+ LDL N LE++ +G L LR L L NQL LPPE+G+L+ L LD+S NRL
Sbjct: 175 KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 149 LPERL-------HMCLS----------------LQYLTVDRNRLWYVPRHLCQLPSLNEL 185
LP L + LS L L VD+NRL V + +L+EL
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 186 SMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
+ N L LP LG+ +L + VD N HL+ LP
Sbjct: 295 ILTENLLMALPRSLGKLTKLTNLNVDRN-HLEALP 328
Score = 94.4 bits (233), Expect = 1e-19
Identities = 72/211 (34%), Positives = 107/211 (50%), Gaps = 5/211 (2%)
Query: 18 KNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
+ L L+ L P + L L +L + N + LP +A + LVEL + N+I
Sbjct: 39 EELLLDANQLRELPKPFFR---LLNLRKLGLSDNEIQRLPPEVANFM-QLVELDVSRNDI 94
Query: 78 VVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQ 137
+PE+I L+ D S N L + +LR+L HL L + LQ LP +VG+L L
Sbjct: 95 PEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLV 154
Query: 138 TLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPL 197
TL++ N L +LP L + L+ L + N L +P L LP+L EL + N+L+ LP
Sbjct: 155 TLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPP 214
Query: 198 DLGRSRELQYVYVDNNIHLKGLPSYLYNKVI 228
+LG R L + V N L+ LP+ L V+
Sbjct: 215 ELGNLRRLVCLDVSEN-RLEELPAELGGLVL 244
Score = 76.6 bits (187), Expect = 3e-14
Identities = 60/172 (34%), Positives = 82/172 (47%), Gaps = 5/172 (2%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L ++ L P EL GL L L + +N L LP+ + Q L L L + N +
Sbjct: 225 LDVSENRLEELPAEL---GGLVLLTDLLLSQNLLRRLPDGIGQ-LKQLSILKVDQNRLCE 280
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
V EAIG L L L++N L + +G+L L +L + N L+ LPPE+G L L
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNR 191
+ NRL LP L L L V NRL +P L L +L L +A N+
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 100 bits (250), Expect = 2e-21
Identities = 60/162 (37%), Positives = 96/162 (59%), Gaps = 1/162 (0%)
Query: 40 LQYLERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
L L+ + +K N+L ++ E ++ Q L L L L N+I +P IG+L L+ L L+ N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
+E + ++ R LR+L L++N L FLP ++G L+ LQ L I+ NR+ TLP L C
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLG 200
L+ L + N L +P + +L +L ++ + GNRL LP++LG
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELG 774
Score = 96.3 bits (238), Expect = 4e-20
Identities = 62/198 (31%), Positives = 112/198 (56%), Gaps = 5/198 (2%)
Query: 26 NLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG 85
NL P +++ D G+ +L++L + + N +K+ NL EL L ++ +P +I
Sbjct: 554 NLSKLP-QVVTDVGV-HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 86 SLVKLQCLDLSDNALEIVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
SL LQ +DL DN L+ + I L L L+L N + ++P ++G+L L+ L ++
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSR 203
N++ +P +L C L+YL + N L ++P + L +L L++ NR+ LP +L + R
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 204 ELQYVYVDNNIHLKGLPS 221
+L+ +++ NN+ L+ LPS
Sbjct: 732 KLRALHLGNNV-LQSLPS 748
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNAL 100
L L + R L +P ++ L NL E+ L NN+ + E I L +L CL L N +
Sbjct: 593 LTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 101 EIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
+ +IG L L L L N+++ +P ++ ++L+ LD+S N L LP + + +LQ
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
L + NR+ +P L Q L L + N L LP +G L + + N L+ LP
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLP 770
Score = 73.2 bits (178), Expect = 4e-13
Identities = 48/150 (32%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Query: 33 ELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQC 92
E++ + L L L + N + +P + L NL LYL+ N I +P + KL+
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGN-LTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 93 LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPER 152
LDLS N L + +IG L+ L++L + N+++ LPPE+ ++L+ L + N L +LP R
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSR 749
Query: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQLPSL 182
+ +L + + NRL +P L + P L
Sbjct: 750 VGELTNLTQIELRGNRLECLPVELGECPLL 779
Score = 67.4 bits (163), Expect = 2e-11
Identities = 46/148 (31%), Positives = 65/148 (43%), Gaps = 27/148 (18%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
I + L + L+LN + P +L L+YL+
Sbjct: 656 IQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLD------------------------ 691
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L NN+ +P IG L LQ L ++ N +E + PE+ + R LR L L NN LQ LP
Sbjct: 692 ---LSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMC 156
VG+L L +++ NRL LP L C
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGEC 776
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 100 bits (250), Expect = 2e-21
Identities = 60/162 (37%), Positives = 96/162 (59%), Gaps = 1/162 (0%)
Query: 40 LQYLERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
L L+ + +K N+L ++ E ++ Q L L L L N+I +P IG+L L+ L L+ N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
+E + ++ R LR+L L++N L FLP ++G L+ LQ L I+ NR+ TLP L C
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLG 200
L+ L + N L +P + +L +L ++ + GNRL LP++LG
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELG 774
Score = 96.3 bits (238), Expect = 4e-20
Identities = 62/198 (31%), Positives = 112/198 (56%), Gaps = 5/198 (2%)
Query: 26 NLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG 85
NL P +++ D G+ +L++L + + N +K+ NL EL L ++ +P +I
Sbjct: 554 NLSKLP-QVVTDVGV-HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 86 SLVKLQCLDLSDNALEIVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
SL LQ +DL DN L+ + I L L L+L N + ++P ++G+L L+ L ++
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSR 203
N++ +P +L C L+YL + N L ++P + L +L L++ NR+ LP +L + R
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 204 ELQYVYVDNNIHLKGLPS 221
+L+ +++ NN+ L+ LPS
Sbjct: 732 KLRALHLGNNV-LQSLPS 748
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNAL 100
L L + R L +P ++ L NL E+ L NN+ + E I L +L CL L N +
Sbjct: 593 LTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 101 EIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
+ +IG L L L L N+++ +P ++ ++L+ LD+S N L LP + + +LQ
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
L + NR+ +P L Q L L + N L LP +G L + + N L+ LP
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLP 770
Score = 73.2 bits (178), Expect = 4e-13
Identities = 48/150 (32%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Query: 33 ELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQC 92
E++ + L L L + N + +P + L NL LYL+ N I +P + KL+
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGN-LTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 93 LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPER 152
LDLS N L + +IG L+ L++L + N+++ LPPE+ ++L+ L + N L +LP R
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSR 749
Query: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQLPSL 182
+ +L + + NRL +P L + P L
Sbjct: 750 VGELTNLTQIELRGNRLECLPVELGECPLL 779
Score = 67.4 bits (163), Expect = 2e-11
Identities = 46/148 (31%), Positives = 65/148 (43%), Gaps = 27/148 (18%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
I + L + L+LN + P +L L+YL+
Sbjct: 656 IQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLD------------------------ 691
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L NN+ +P IG L LQ L ++ N +E + PE+ + R LR L L NN LQ LP
Sbjct: 692 ---LSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMC 156
VG+L L +++ NRL LP L C
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGEC 776
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 100 bits (250), Expect = 2e-21
Identities = 60/162 (37%), Positives = 96/162 (59%), Gaps = 1/162 (0%)
Query: 40 LQYLERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
L L+ + +K N+L ++ E ++ Q L L L L N+I +P IG+L L+ L L+ N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
+E + ++ R LR+L L++N L FLP ++G L+ LQ L I+ NR+ TLP L C
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLG 200
L+ L + N L +P + +L +L ++ + GNRL LP++LG
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELG 774
Score = 96.3 bits (238), Expect = 4e-20
Identities = 62/198 (31%), Positives = 112/198 (56%), Gaps = 5/198 (2%)
Query: 26 NLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG 85
NL P +++ D G+ +L++L + + N +K+ NL EL L ++ +P +I
Sbjct: 554 NLSKLP-QVVTDVGV-HLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611
Query: 86 SLVKLQCLDLSDNALEIVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
SL LQ +DL DN L+ + I L L L+L N + ++P ++G+L L+ L ++
Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSR 203
N++ +P +L C L+YL + N L ++P + L +L L++ NR+ LP +L + R
Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCR 731
Query: 204 ELQYVYVDNNIHLKGLPS 221
+L+ +++ NN+ L+ LPS
Sbjct: 732 KLRALHLGNNV-LQSLPS 748
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNAL 100
L L + R L +P ++ L NL E+ L NN+ + E I L +L CL L N +
Sbjct: 593 LTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 101 EIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
+ +IG L L L L N+++ +P ++ ++L+ LD+S N L LP + + +LQ
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
L + NR+ +P L Q L L + N L LP +G L + + N L+ LP
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLP 770
Score = 73.2 bits (178), Expect = 4e-13
Identities = 48/150 (32%), Positives = 80/150 (53%), Gaps = 1/150 (0%)
Query: 33 ELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQC 92
E++ + L L L + N + +P + L NL LYL+ N I +P + KL+
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGN-LTNLERLYLNRNKIEKIPTQLFYCRKLRY 689
Query: 93 LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPER 152
LDLS N L + +IG L+ L++L + N+++ LPPE+ ++L+ L + N L +LP R
Sbjct: 690 LDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSR 749
Query: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQLPSL 182
+ +L + + NRL +P L + P L
Sbjct: 750 VGELTNLTQIELRGNRLECLPVELGECPLL 779
Score = 67.4 bits (163), Expect = 2e-11
Identities = 46/148 (31%), Positives = 65/148 (43%), Gaps = 27/148 (18%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
I + L + L+LN + P +L L+YL+
Sbjct: 656 IQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLD------------------------ 691
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L NN+ +P IG L LQ L ++ N +E + PE+ + R LR L L NN LQ LP
Sbjct: 692 ---LSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPS 748
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMC 156
VG+L L +++ NRL LP L C
Sbjct: 749 RVGELTNLTQIELRGNRLECLPVELGEC 776
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 100 bits (249), Expect = 2e-21
Identities = 72/188 (38%), Positives = 106/188 (56%), Gaps = 4/188 (2%)
Query: 43 LERLYMKRNSLTSLPENLA-QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
L+ L +K N L S+ E L+ Q LV L L N I VPE + L L+ L LS N LE
Sbjct: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
Query: 102 IVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQY 161
+ ++G LR L +++N L LPPEVG L+ LQ L +S N L LPE L C L+
Sbjct: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
Query: 162 LTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQY--VYVDNNIHLKGL 219
L + N+L + H+ L +L+ L + GNRL LP +LG L+ + V++ ++ +GL
Sbjct: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLY-QGL 785
Query: 220 PSYLYNKV 227
P+ + +K+
Sbjct: 786 PAEVRDKM 793
Score = 83.6 bits (205), Expect = 3e-16
Identities = 59/174 (33%), Positives = 93/174 (53%), Gaps = 2/174 (1%)
Query: 42 YLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
+L+RL + + + N +KL L EL L + + +P A+ SL LQ LDL DN L
Sbjct: 559 HLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLR 618
Query: 102 IV--CPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
+ R L LRL +NQ+ ++P V L+ L+ L +S N+L TLP +L +C L
Sbjct: 619 SIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGL 678
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ L V N L +P + L +L L+++ N L LP +L R+L+ + + +N
Sbjct: 679 RLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDN 732
Score = 73.2 bits (178), Expect = 4e-13
Identities = 56/152 (36%), Positives = 76/152 (50%), Gaps = 4/152 (2%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
+S K L L + + + P + K L+ LE+LY+ N L +LP L L
Sbjct: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRK---LRSLEQLYLSYNKLETLPSQLG-LCSGLR 679
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L + N + +P +G L LQ L LS NALE + E+ R LR L L +NQL L P
Sbjct: 680 LLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSP 739
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
VG L+ L L++ NRL LPE L C L+
Sbjct: 740 HVGALRALSRLELKGNRLEALPEELGNCGGLK 771
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 97.8 bits (242), Expect = 1e-20
Identities = 72/249 (28%), Positives = 122/249 (48%), Gaps = 28/249 (11%)
Query: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQ 62
+E+ K ++ R E L L+ R++H P + + L L LY+ N L SLP +
Sbjct: 88 AEVIKELNKCREENSMRLDLSKRSIHILPSSIKE---LTQLTELYLYSNKLQSLPAEVGC 144
Query: 63 KLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE--------------------- 101
L NL+ L L N++ +P+++ +L KL+ LDL N L
Sbjct: 145 -LVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNR 203
Query: 102 --IVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
V +I L L L + N+++ LP E+G+L L TLD++ N+L LP+ + C +
Sbjct: 204 ITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQI 263
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGL 219
L + N L +P + L SL+ L + NRL+ +P L + L+ + ++NN ++ L
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENN-NISTL 322
Query: 220 PSYLYNKVI 228
P L + ++
Sbjct: 323 PESLLSSLV 331
Score = 89.4 bits (220), Expect = 5e-18
Identities = 52/175 (29%), Positives = 94/175 (53%)
Query: 46 LYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP 105
L M+ N + +P + + L +L + N + +P G+ + L+L+ N L +
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Query: 106 EIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVD 165
++ L +L L L+NN L+ LP +G+L++L+ LD+ N+L +LP + LQ L +
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLT 479
Query: 166 RNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
N+L +PR + L +L L + N L LP ++G L+ +Y+++N +L LP
Sbjct: 480 NNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLP 534
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 97.8 bits (242), Expect = 1e-20
Identities = 76/245 (31%), Positives = 131/245 (53%), Gaps = 11/245 (4%)
Query: 26 NLHHFPLELLKDE--GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEA 83
N+ H L++L +E L+ L+ LY++ N LT + E Q L NL +L L +N++ VP +
Sbjct: 134 NVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQ-LSNLEDLDLSNNHLTTVPAS 192
Query: 84 IGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
SL L L+LS N L+ + EI R++ L+HL +N L+ +PPE+ ++ L+ L +
Sbjct: 193 FSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRR 252
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVP-RHLCQLPSLNELSMAGNRLAFLPLDLGRS 202
N+L LPE C L+ L V N++ + HL L S+ L + N+L +P ++
Sbjct: 253 NKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILL 311
Query: 203 RELQYVYVDNNIHLKGLPSYLYN---KVIGCSGCGAPIQVSEVKLLSFSSGQRTVFLPAE 259
R L+ + + NN + LP L N K + G P++ +++S + + +L ++
Sbjct: 312 RSLERLDLSNN-DISSLPYSLGNLHLKFLALE--GNPLRTIRREIISKGTQEVLKYLRSK 368
Query: 260 VKAIG 264
+K G
Sbjct: 369 IKDDG 373
Score = 88.2 bits (217), Expect = 1e-17
Identities = 60/180 (33%), Positives = 91/180 (50%), Gaps = 2/180 (1%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
L +L + N L SL ++L + LP L L +H N + +P AI L LQ L++S N L+I
Sbjct: 84 LTKLIISNNKLQSLTDDL-RLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
+ EI LR L+ L L +N+L + L L+ LD+S N L T+P SL L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 163 TVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSY 222
+ N L +P + ++ L L N L +P +L L+ +Y+ N L+ LP +
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRN-KLRFLPEF 261
Score = 73.6 bits (179), Expect = 3e-13
Identities = 45/158 (28%), Positives = 84/158 (53%), Gaps = 1/158 (0%)
Query: 66 NLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQF 125
+L +L + +N + + + + L L LD+ DN L + I L L+ L +++N+L+
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 126 LPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNEL 185
LP E+ +L+ L+ L + N L + E +L+ L + N L VP L SL L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 186 SMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
+++ N L LP ++ R + L+++ ++N+ L+ +P L
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNL-LETIPPEL 239
Score = 68.2 bits (165), Expect = 1e-11
Identities = 48/164 (29%), Positives = 84/164 (51%), Gaps = 4/164 (2%)
Query: 54 TSLPENL--AQKLPNLVELYLHSNNIVVVPEAIGSLVKLQC-LDLSDNALEIVCPEIGRL 110
T +P+ + A K + + N + +P+ + L ++ +DLS N L + E+ L
Sbjct: 412 TLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL 471
Query: 111 RALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLW 170
+ L L L NN L LP E+ L LQT+++S NR LPE L+ +L+ + + N++
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
Query: 171 YV-PRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
V P+ + + +L L + N L +P +LG L+ + +D N
Sbjct: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 64.7 bits (156), Expect = 1e-10
Identities = 51/195 (26%), Positives = 88/195 (45%), Gaps = 24/195 (12%)
Query: 50 RNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSL---------------------- 87
R+ TS+P+ L + +L L N+ VP+ + +
Sbjct: 21 RDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWE 80
Query: 88 -VKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRL 146
L L +S+N L+ + ++ L AL L + +NQL LP + +L+ LQ L++S N+L
Sbjct: 81 QTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL 140
Query: 147 LTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQ 206
LPE + +L+ L + N L + QL +L +L ++ N L +P L
Sbjct: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 207 YVYVDNNIHLKGLPS 221
+ + +N LK LP+
Sbjct: 201 RLNLSSN-ELKSLPA 214
Score = 64.7 bits (156), Expect = 1e-10
Identities = 52/140 (37%), Positives = 77/140 (55%), Gaps = 7/140 (5%)
Query: 11 VARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVEL 70
+ R+++ K+L N L P EL G++ LE LY++RN L LPE + L L EL
Sbjct: 216 INRMKRLKHLDCNSNLLETIPPELA---GMESLELLYLRRNKLRFLPEFPSCSL--LKEL 270
Query: 71 YLHSNNIVVVP-EAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
++ N I ++ E + L + LDL DN L+ V EI LR+L L L+NN + LP
Sbjct: 271 HVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS 330
Query: 130 VGDLKELQTLDISTNRLLTL 149
+G+L L+ L + N L T+
Sbjct: 331 LGNL-HLKFLALEGNPLRTI 349
Score = 52.4 bits (124), Expect = 6e-07
Identities = 47/196 (23%), Positives = 92/196 (46%), Gaps = 7/196 (3%)
Query: 2 ASELCKTI-SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLER-----LYMKRNSLTS 55
A+E T+ S +R+ H + L + L+ DE ++ + +N L
Sbjct: 380 ATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCE 439
Query: 56 LPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRH 115
+P+ + + + ++ L N + + + L KL LDL +N L + E+ L L+
Sbjct: 440 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 499
Query: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNRLLTL-PERLHMCLSLQYLTVDRNRLWYVPR 174
+ L+ N+ + LP + + L+T+ IS N++ ++ P+++ M +L L + N L +P
Sbjct: 500 INLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPP 559
Query: 175 HLCQLPSLNELSMAGN 190
L +L L + GN
Sbjct: 560 ELGNCVNLRTLLLDGN 575
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 97.4 bits (241), Expect = 2e-20
Identities = 66/203 (32%), Positives = 106/203 (52%), Gaps = 5/203 (2%)
Query: 7 KTISVARLEKHKNLFLNYRNLHHFPLELLKDE--GLQYLERLYMKRNSLTSLPENLA-QK 63
K + + L+K NL L H LE + L L+ L +K N+L S+ E ++ Q
Sbjct: 578 KLVMLNNLKKMTNL--TELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQH 635
Query: 64 LPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL 123
L L L L N+I +PE I L L+ L S N +E++ + +R+L L+ N +
Sbjct: 636 LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDI 695
Query: 124 QFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLN 183
+F+PPE+G L+ LQ I+ N++ +LP+ L+ C L+ L + +N L + + L L+
Sbjct: 696 RFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLS 755
Query: 184 ELSMAGNRLAFLPLDLGRSRELQ 206
L + GN LP +LG R L+
Sbjct: 756 YLDVKGNHFEILPPELGDCRALK 778
Score = 80.1 bits (196), Expect = 3e-15
Identities = 49/174 (28%), Positives = 93/174 (53%), Gaps = 2/174 (1%)
Query: 42 YLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
+L+++ + + + N +K+ NL EL L ++ +P A+ SL+ LQ LDL +N L+
Sbjct: 566 HLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLK 625
Query: 102 IVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
+ + LR L L+L +N + ++P + L L+ L S N++ LP L +C +
Sbjct: 626 SIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKI 685
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+YL + N + ++P + L SL S+ N++ LP +L ++L+ + + N
Sbjct: 686 RYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKN 739
Score = 47.8 bits (112), Expect = 2e-05
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 6/117 (5%)
Query: 16 KHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSN 75
K + L L+Y ++ P E+ + LQY + N + SLP+ L L L + N
Sbjct: 684 KIRYLDLSYNDIRFIPPEIGVLQSLQYFS---ITCNKVESLPDEL-YFCKKLKTLKIGKN 739
Query: 76 NIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQF--LPPEV 130
++ V+ IG+L+ L LD+ N EI+ PE+G RAL+ L F LP +V
Sbjct: 740 SLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 96.7 bits (239), Expect = 3e-20
Identities = 69/208 (33%), Positives = 109/208 (52%), Gaps = 5/208 (2%)
Query: 13 RLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYL 72
RL K + L L L P + + L LERL + N T +PE L Q L L E ++
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNR---LTQLERLDLGSNEFTEVPEVLEQ-LSGLKEFWM 214
Query: 73 HSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGD 132
+N + +P IGSL +L LD+S N +E+V I L+ L L++N LQ LP +G
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGS 274
Query: 133 LKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRL 192
LK + TL I N+L+ LP+ + +S++ L N + +P + QL +L + N L
Sbjct: 275 LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYL 334
Query: 193 AFLPLDLGRSRELQYVYVDNNIHLKGLP 220
LP ++G + + +++ +N L+ LP
Sbjct: 335 QQLPPEIGSWKNITVLFLHSN-KLETLP 361
Score = 90.5 bits (223), Expect = 2e-18
Identities = 60/195 (30%), Positives = 103/195 (52%), Gaps = 6/195 (3%)
Query: 22 LNYRNLHHFPLELLKDEGL---QYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78
L Y ++ +E++ +EG+ + L+ L + NSL LPE + L N+ L + N ++
Sbjct: 232 LTYLDVSKNNIEMV-EEGISTCENLQDLLLSSNSLQQLPETIGS-LKNITTLKIDENQLM 289
Query: 79 VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138
+P++IG L+ ++ LD S N +E + IG+L LR +N LQ LPPE+G K +
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITV 349
Query: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNR-LAFLPL 197
L + +N+L TLPE + L+ + + NRL +P +L L + ++ N+ +PL
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 198 DLGRSRELQYVYVDN 212
E Q + + N
Sbjct: 410 QKETDSETQKMVLTN 424
Score = 89.4 bits (220), Expect = 5e-18
Identities = 64/196 (32%), Positives = 97/196 (49%), Gaps = 4/196 (2%)
Query: 18 KNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
+ L+L+ + P +L Q L +L + N LT+LP ++A L NL EL + N I
Sbjct: 49 EELYLDANQIEELPKQLFN---CQSLHKLSLPDNDLTTLPASIAN-LINLRELDVSKNGI 104
Query: 78 VVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQ 137
PE I + L ++ S N + + +L L L L + L+FLP G L +LQ
Sbjct: 105 QEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQ 164
Query: 138 TLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPL 197
L++ N+L LP+ ++ L+ L + N VP L QL L E M NRL F+P
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 198 DLGRSRELQYVYVDNN 213
+G ++L Y+ V N
Sbjct: 225 FIGSLKQLTYLDVSKN 240
Score = 84.3 bits (207), Expect = 2e-16
Identities = 70/268 (26%), Positives = 123/268 (45%), Gaps = 21/268 (7%)
Query: 10 SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVE 69
S+A L + L ++ + FP + + L +E N ++ LP+ +Q L NL +
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV---NPISKLPDGFSQLL-NLTQ 142
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
LYL+ + +P G L KLQ L+L +N L+++ + RL L L L +N+ +P
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+ L L+ + NRL +P + L YL V +N + V + +L +L ++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 190 NRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKV----IGCSGCGAPIQVSEVKLL 245
N L LP +G + + + +D N L LP + + + CS +EV+ L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEELDCS-------FNEVEAL 314
Query: 246 SFSSGQRTVFLPAEVKAIGTEHDHVLPL 273
S GQ T ++ +H+++ L
Sbjct: 315 PSSIGQLT-----NLRTFAADHNYLQQL 337
Score = 77.0 bits (188), Expect = 2e-14
Identities = 47/174 (27%), Positives = 90/174 (51%), Gaps = 1/174 (0%)
Query: 40 LQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNA 99
L+ L L + +N++ + E ++ NL +L L SN++ +PE IGSL + L + +N
Sbjct: 229 LKQLTYLDVSKNNIEMVEEGIST-CENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 100 LEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
L + IG L ++ L + N+++ LP +G L L+T N L LP + ++
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
L + N+L +P + + L ++++ NRL LP + ++L +++ +N
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 96.7 bits (239), Expect = 3e-20
Identities = 69/208 (33%), Positives = 109/208 (52%), Gaps = 5/208 (2%)
Query: 13 RLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYL 72
RL K + L L L P + + L LERL + N T +PE L Q L L E ++
Sbjct: 159 RLTKLQILELRENQLKMLPKTMNR---LTQLERLDLGSNEFTEVPEVLEQ-LSGLKEFWM 214
Query: 73 HSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGD 132
+N + +P IGSL +L LD+S N +E+V I L+ L L++N LQ LP +G
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGS 274
Query: 133 LKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRL 192
LK + TL I N+L+ LP+ + +S++ L N + +P + QL +L + N L
Sbjct: 275 LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYL 334
Query: 193 AFLPLDLGRSRELQYVYVDNNIHLKGLP 220
LP ++G + + +++ +N L+ LP
Sbjct: 335 QQLPPEIGSWKNITVLFLHSN-KLETLP 361
Score = 90.5 bits (223), Expect = 2e-18
Identities = 60/195 (30%), Positives = 103/195 (52%), Gaps = 6/195 (3%)
Query: 22 LNYRNLHHFPLELLKDEGL---QYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78
L Y ++ +E++ +EG+ + L+ L + NSL LPE + L N+ L + N ++
Sbjct: 232 LTYLDVSKNNIEMV-EEGISTCENLQDLLLSSNSLQQLPETIGS-LKNITTLKIDENQLM 289
Query: 79 VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138
+P++IG L+ ++ LD S N +E + IG+L LR +N LQ LPPE+G K +
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITV 349
Query: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNR-LAFLPL 197
L + +N+L TLPE + L+ + + NRL +P +L L + ++ N+ +PL
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 198 DLGRSRELQYVYVDN 212
E Q + + N
Sbjct: 410 QKETDSETQKMVLTN 424
Score = 89.4 bits (220), Expect = 5e-18
Identities = 64/196 (32%), Positives = 97/196 (49%), Gaps = 4/196 (2%)
Query: 18 KNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNI 77
+ L+L+ + P +L Q L +L + N LT+LP ++A L NL EL + N I
Sbjct: 49 EELYLDANQIEELPKQLFN---CQSLHKLSLPDNDLTTLPASIAN-LINLRELDVSKNGI 104
Query: 78 VVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQ 137
PE I + L ++ S N + + +L L L L + L+FLP G L +LQ
Sbjct: 105 QEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQ 164
Query: 138 TLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPL 197
L++ N+L LP+ ++ L+ L + N VP L QL L E M NRL F+P
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
Query: 198 DLGRSRELQYVYVDNN 213
+G ++L Y+ V N
Sbjct: 225 FIGSLKQLTYLDVSKN 240
Score = 84.3 bits (207), Expect = 2e-16
Identities = 70/268 (26%), Positives = 123/268 (45%), Gaps = 21/268 (7%)
Query: 10 SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVE 69
S+A L + L ++ + FP + + L +E N ++ LP+ +Q L NL +
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV---NPISKLPDGFSQLL-NLTQ 142
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
LYL+ + +P G L KLQ L+L +N L+++ + RL L L L +N+ +P
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+ L L+ + NRL +P + L YL V +N + V + +L +L ++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 190 NRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKV----IGCSGCGAPIQVSEVKLL 245
N L LP +G + + + +D N L LP + + + CS +EV+ L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEELDCS-------FNEVEAL 314
Query: 246 SFSSGQRTVFLPAEVKAIGTEHDHVLPL 273
S GQ T ++ +H+++ L
Sbjct: 315 PSSIGQLT-----NLRTFAADHNYLQQL 337
Score = 77.0 bits (188), Expect = 2e-14
Identities = 47/174 (27%), Positives = 90/174 (51%), Gaps = 1/174 (0%)
Query: 40 LQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNA 99
L+ L L + +N++ + E ++ NL +L L SN++ +PE IGSL + L + +N
Sbjct: 229 LKQLTYLDVSKNNIEMVEEGIST-CENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 100 LEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
L + IG L ++ L + N+++ LP +G L L+T N L LP + ++
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
L + N+L +P + + L ++++ NRL LP + ++L +++ +N
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 95.5 bits (236), Expect = 7e-20
Identities = 62/161 (38%), Positives = 90/161 (55%), Gaps = 1/161 (0%)
Query: 39 GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
GL +L L + NSL +LP + Q + L L L N + +PEA+G+L L L ++ N
Sbjct: 123 GLAHLAHLDLSFNSLETLPACVLQ-MRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
L+ + P +G L L+ L L+ N L LPPE+G L L L++++NRL +LP L S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
L+ L + N L VP L +LP L L + N+L LP +L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 85.9 bits (211), Expect = 5e-17
Identities = 66/174 (37%), Positives = 91/174 (52%), Gaps = 2/174 (1%)
Query: 50 RNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGR 109
R +LT+LP L+ L +L L L N++ +P + + L L LS N L + +G
Sbjct: 111 RGALTNLPAGLSG-LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169
L AL L + +N+LQ LPP +G L LQ LD+S N L TLP + SL L + NRL
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Query: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
+P L L SL L + N LA +P DL R L + + +N L+ LP L
Sbjct: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/162 (36%), Positives = 87/162 (53%), Gaps = 4/162 (2%)
Query: 19 NLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78
+L L++ +L P +L+ GL L + N L+ LPE L LP L L + N +
Sbjct: 129 HLDLSFNSLETLPACVLQMRGLG---ALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQ 184
Query: 79 VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138
+P A+G+L LQ LDLS N L+ + PEIG L +L L LA+N+LQ LP + L+ L+
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
L + +N L ++P L L L + N+L +P L P
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 95.5 bits (236), Expect = 7e-20
Identities = 62/161 (38%), Positives = 90/161 (55%), Gaps = 1/161 (0%)
Query: 39 GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
GL +L L + NSL +LP + Q + L L L N + +PEA+G+L L L ++ N
Sbjct: 123 GLAHLAHLDLSFNSLETLPACVLQ-MRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
L+ + P +G L L+ L L+ N L LPPE+G L L L++++NRL +LP L S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
L+ L + N L VP L +LP L L + N+L LP +L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 85.9 bits (211), Expect = 5e-17
Identities = 66/174 (37%), Positives = 91/174 (52%), Gaps = 2/174 (1%)
Query: 50 RNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGR 109
R +LT+LP L+ L +L L L N++ +P + + L L LS N L + +G
Sbjct: 111 RGALTNLPAGLSG-LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169
L AL L + +N+LQ LPP +G L LQ LD+S N L TLP + SL L + NRL
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Query: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
+P L L SL L + N LA +P DL R L + + +N L+ LP L
Sbjct: 230 QSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN-QLRDLPPEL 282
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/162 (36%), Positives = 87/162 (53%), Gaps = 4/162 (2%)
Query: 19 NLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIV 78
+L L++ +L P +L+ GL L + N L+ LPE L LP L L + N +
Sbjct: 129 HLDLSFNSLETLPACVLQMRGLG---ALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQ 184
Query: 79 VVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQT 138
+P A+G+L LQ LDLS N L+ + PEIG L +L L LA+N+LQ LP + L+ L+
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 139 LDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
L + +N L ++P L L L + N+L +P L P
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAP 286
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 90.9 bits (224), Expect = 2e-18
Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 10/205 (4%)
Query: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
+ L K ++VA LE L L P + LQ L+ +K N++ ++ E ++
Sbjct: 629 NSLKKMMNVAELE------LQNCELERIPHAIFSLSNLQELD---LKSNNIRTIEEIISF 679
Query: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Q L L L L N IV +P +I + L+ L S+N LE + + L+ LR L ++ N
Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN 739
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
+ +P E+G L+ LQ L I+ N++ LP++L C+ L+ L + +N + +P + QL
Sbjct: 740 NISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQ 206
L +L + GN L LP LG+ R L+
Sbjct: 800 LTQLELKGNCLDRLPAQLGQCRMLK 824
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/162 (32%), Positives = 87/162 (53%), Gaps = 3/162 (1%)
Query: 64 LPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
L NL EL L SNNI + E I L +L CL L N + + P I ++ L L +NN
Sbjct: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
+L+ LP V L++L+ LD+S N + +P + + +LQ+L + N++ +P+ L +
Sbjct: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
L L++ N + LP +G+ +L + + N L LP+ L
Sbjct: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNC-LDRLPAQL 817
Score = 77.8 bits (190), Expect = 1e-14
Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 29/218 (13%)
Query: 22 LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV-- 79
LN N LE L++ L++L+ L++K N LT +P N+ P+L +L +H++ +
Sbjct: 571 LNSENNKMIGLESLRE--LRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV 627
Query: 80 ----------------------VPEAIGSLVKLQCLDLSDNALEIVCPEIG--RLRALRH 115
+P AI SL LQ LDL N + + I L+ L
Sbjct: 628 LNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTC 687
Query: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRH 175
L+L +N++ +PP + +K L++L S N+L +LP + L+ L V N + +P
Sbjct: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 176 LCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ L +L L + GN++ LP L + +L+ + + N
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 90.9 bits (224), Expect = 2e-18
Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 10/205 (4%)
Query: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
+ L K ++VA LE L L P + LQ L+ +K N++ ++ E ++
Sbjct: 629 NSLKKMMNVAELE------LQNCELERIPHAIFSLSNLQELD---LKSNNIRTIEEIISF 679
Query: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Q L L L L N IV +P +I + L+ L S+N LE + + L+ LR L ++ N
Sbjct: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN 739
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
+ +P E+G L+ LQ L I+ N++ LP++L C+ L+ L + +N + +P + QL
Sbjct: 740 NISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQ 206
L +L + GN L LP LG+ R L+
Sbjct: 800 LTQLELKGNCLDRLPAQLGQCRMLK 824
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/162 (32%), Positives = 87/162 (53%), Gaps = 3/162 (1%)
Query: 64 LPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
L NL EL L SNNI + E I L +L CL L N + + P I ++ L L +NN
Sbjct: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
+L+ LP V L++L+ LD+S N + +P + + +LQ+L + N++ +P+ L +
Sbjct: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
L L++ N + LP +G+ +L + + N L LP+ L
Sbjct: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNC-LDRLPAQL 817
Score = 77.8 bits (190), Expect = 1e-14
Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 29/218 (13%)
Query: 22 LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV-- 79
LN N LE L++ L++L+ L++K N LT +P N+ P+L +L +H++ +
Sbjct: 571 LNSENNKMIGLESLRE--LRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV 627
Query: 80 ----------------------VPEAIGSLVKLQCLDLSDNALEIVCPEIG--RLRALRH 115
+P AI SL LQ LDL N + + I L+ L
Sbjct: 628 LNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTC 687
Query: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRH 175
L+L +N++ +PP + +K L++L S N+L +LP + L+ L V N + +P
Sbjct: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
Query: 176 LCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ L +L L + GN++ LP L + +L+ + + N
Sbjct: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 90.5 bits (223), Expect = 2e-18
Identities = 55/192 (28%), Positives = 101/192 (52%), Gaps = 3/192 (1%)
Query: 22 LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVP 81
L + L FP ++LK ++Y++ LY+ +N + + + L L L L N + +P
Sbjct: 148 LEAKGLQEFPKDILK---IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
Query: 82 EAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDI 141
I L L+ L++S N + + EI +L +R L NN ++ P ++ L L+ L +
Sbjct: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 142 STNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGR 201
N+L +P+ L +L+ L ++ N+L P+ LC LP L L + GN ++ LP ++
Sbjct: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
Query: 202 SRELQYVYVDNN 213
+ L+ + +D+N
Sbjct: 325 LKNLETLLMDHN 336
Score = 87.4 bits (215), Expect = 2e-17
Identities = 59/208 (28%), Positives = 105/208 (50%), Gaps = 7/208 (3%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
I + +K + L+Y + +FPL L + L YL + N ++ +P +++ L+
Sbjct: 458 IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLS---VNGNYISEIPVDISFS-KQLL 513
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L L N +++ E SL+ L+ LDL N ++ + I + +L L L N+ + P
Sbjct: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMA 188
E+ L+ LQ LD+S N+L + + +Q L N+ + P LCQL SL +L+++
Sbjct: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
Query: 189 ---GNRLAFLPLDLGRSRELQYVYVDNN 213
G +L LP +L +L+ + + NN
Sbjct: 634 QIKGRKLTRLPGELSNMTQLKELDISNN 661
Score = 85.5 bits (210), Expect = 7e-17
Identities = 64/225 (28%), Positives = 113/225 (50%), Gaps = 10/225 (4%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L L P E+ + L L L + N ++ +P+ ++Q L N+ +L+ ++N I
Sbjct: 193 LSLQENGLSSLPSEI---QLLHNLRILNVSHNHISHIPKEISQ-LGNIRQLFFYNNYIEN 248
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
P + L L+ L L N L + + L+ LR L L NQL P + L +L +L
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
D++ N + +LP+ + +L+ L +D N+L ++ + QL + EL +A N+L + +
Sbjct: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
Query: 200 GRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKL 244
REL+ + +D N+ LK +P + I C + +S+ KL
Sbjct: 369 ENFRELRILILDKNL-LKNIP-----EKISCCAMLECLSLSDNKL 407
Score = 84.0 bits (206), Expect = 2e-16
Identities = 60/207 (28%), Positives = 106/207 (51%), Gaps = 4/207 (1%)
Query: 11 VARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVEL 70
+++L + LF + +FP +L E L LE L + +N L +P+ L L L L
Sbjct: 230 ISQLGNIRQLFFYNNYIENFPSDL---ECLGNLEILSLGKNKLRHIPDTLPS-LKTLRVL 285
Query: 71 YLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEV 130
L N + P+A+ L KL LDL+ N + + EI L+ L L + +N+L FL E+
Sbjct: 286 NLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEI 345
Query: 131 GDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGN 190
L +++ L ++ N+L + ++ L+ L +D+N L +P + L LS++ N
Sbjct: 346 FQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDN 405
Query: 191 RLAFLPLDLGRSRELQYVYVDNNIHLK 217
+L LP + + L+ ++V+ N +K
Sbjct: 406 KLTELPKYIHKLNNLRKLHVNRNNMVK 432
Score = 80.1 bits (196), Expect = 3e-15
Identities = 55/206 (26%), Positives = 101/206 (49%), Gaps = 10/206 (4%)
Query: 11 VARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVEL 70
+ L+ + L +++ L +E+ + L ++ L + N L E ++ K+ N EL
Sbjct: 322 IRELKNLETLLMDHNKLTFLAVEIFQ---LLKIKELQLADNKL----EVISHKIENFREL 374
Query: 71 ---YLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLP 127
L N + +PE I L+CL LSDN L + I +L LR L + N + +
Sbjct: 375 RILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKIT 434
Query: 128 PEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSM 187
+ L + +L+ S N + +P + C + + + N++ Y P LC L SL LS+
Sbjct: 435 DCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSV 494
Query: 188 AGNRLAFLPLDLGRSRELQYVYVDNN 213
GN ++ +P+D+ S++L ++ + N
Sbjct: 495 NGNYISEIPVDISFSKQLLHLELSEN 520
Score = 79.7 bits (195), Expect = 4e-15
Identities = 52/178 (29%), Positives = 85/178 (47%), Gaps = 30/178 (16%)
Query: 1 MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENL 60
++S++C + +L N F+ HFP+EL + + L+ L +K LT LP L
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFI------HFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647
Query: 61 AQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLAN 120
+ ++ +L+ LD+S+NA+ + IG LR L L N
Sbjct: 648 S------------------------NMTQLKELDISNNAIREIPRNIGELRNLVSLHAYN 683
Query: 121 NQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQ 178
NQ+ +LPP + L +LQ L++S N L LP ++ SL+ + D N L P +C+
Sbjct: 684 NQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICK 741
Score = 71.2 bits (173), Expect = 1e-12
Identities = 51/197 (25%), Positives = 92/197 (46%), Gaps = 27/197 (13%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
L+ L + +N + +P +++ + +L L L N P + +L LQ LDLS+N L+
Sbjct: 535 LKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQK 593
Query: 103 VCPEIGRLRALRHLRLANNQ--------------------------LQFLPPEVGDLKEL 136
+ +I L+ ++ L ++NQ L LP E+ ++ +L
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653
Query: 137 QTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLP 196
+ LDIS N + +P + +L L N++ Y+P L L L +L+++GN L LP
Sbjct: 654 KELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALP 713
Query: 197 LDLGRSRELQYVYVDNN 213
+ L+ + D+N
Sbjct: 714 SAIYNIFSLKEINFDDN 730
Score = 68.6 bits (166), Expect = 9e-12
Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 1/157 (0%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
LE L + N LT LP+ + KL NL +L+++ NN+V + + I L + L+ S N +
Sbjct: 397 LECLSLSDNKLTELPKYI-HKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITD 455
Query: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
V EI + + + L+ N++ + P + L L L ++ N + +P + L +L
Sbjct: 456 VPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHL 515
Query: 163 TVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
+ N+L H C L +L L + N++ +P +
Sbjct: 516 ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASI 552
Score = 67.4 bits (163), Expect = 2e-11
Identities = 50/197 (25%), Positives = 92/197 (46%), Gaps = 6/197 (3%)
Query: 31 PLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKL 90
P+E+ + Q + ++ + N + P L L +L L ++ N I +P I +L
Sbjct: 457 PIEI---KNCQKIIKIELSYNKIMYFPLGLCA-LDSLYYLSVNGNYISEIPVDISFSKQL 512
Query: 91 QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLP 150
L+LS+N L I L L++L L NQ++ +P + ++ L L + N+ T P
Sbjct: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP 572
Query: 151 ERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYV 210
L +LQ L + N+L + +C L + +L+ + N+ P++L + + L+ + +
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Query: 211 D--NNIHLKGLPSYLYN 225
L LP L N
Sbjct: 633 SQIKGRKLTRLPGELSN 649
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/189 (25%), Positives = 88/189 (46%), Gaps = 7/189 (3%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L FP EL E LQ L+ + N L + ++ L + +L SN +
Sbjct: 561 LILCCNKFETFPRELCTLENLQVLD---LSENQLQKISSDICN-LKGIQKLNFSSNQFIH 616
Query: 80 VPEAIGSLVKLQCLDLSD---NALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKEL 136
P + L L+ L++S L + E+ + L+ L ++NN ++ +P +G+L+ L
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
Query: 137 QTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLP 196
+L N++ LP L LQ L + N L +P + + SL E++ N L P
Sbjct: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
Query: 197 LDLGRSREL 205
+++ + ++L
Sbjct: 737 VEICKGKQL 745
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 89.4 bits (220), Expect = 5e-18
Identities = 65/194 (33%), Positives = 102/194 (52%), Gaps = 3/194 (1%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L+ R L FP L + + +N L +P L + +L L L+ N I V
Sbjct: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV-SLEILNLYHNCIRV 134
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
+PEAI +L L L+LS N L + + L L+ L +NN+L LP E+G LK+L L
Sbjct: 135 IPEAIVNLQMLTYLNLSRNQLSALPACLCGL-PLKVLIASNNKLGSLPEEIGQLKQLMEL 193
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
D+S N + LP+++ SL+ L V RN L +P+ L LP L + + N++ +P+
Sbjct: 194 DVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLP-LVKFDFSCNKVLVIPICF 252
Query: 200 GRSRELQYVYVDNN 213
++LQ + ++NN
Sbjct: 253 REMKQLQVLLLENN 266
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 88.2 bits (217), Expect = 1e-17
Identities = 66/194 (34%), Positives = 101/194 (52%), Gaps = 4/194 (2%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L+ R L FP + L R + RN L+ +P A +L L L+ N I
Sbjct: 62 LSLSGRKLREFPRGAANHD-LTDTTRADLSRNRLSEIPIE-ACHFVSLENLNLYQNCIRY 119
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
+PEAI +L L L++S N L + + L L+ L +NN+L LP E+G L+ L L
Sbjct: 120 IPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMEL 178
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
D+S N + T+P ++ +L+ L V RN L ++P L +LP L L + N++ +P+
Sbjct: 179 DVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCY 237
Query: 200 GRSRELQYVYVDNN 213
R LQ + +DNN
Sbjct: 238 RNLRHLQTITLDNN 251
Score = 82.0 bits (201), Expect = 8e-16
Identities = 60/174 (34%), Positives = 90/174 (51%), Gaps = 12/174 (6%)
Query: 4 ELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQK 63
E C +S+ L ++N + + P +L LQ L L + RN L++LP +L
Sbjct: 100 EACHFVSLENLNLYQNC------IRYIPEAILN---LQALTFLNISRNQLSTLPVHLCN- 149
Query: 64 LPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL 123
LP L L +N +V +PE IG L L LD+S N ++ + +IG L ALR L + N L
Sbjct: 150 LP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHL 208
Query: 124 QFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
LP E+ +L ++ LD S N++ T+P LQ +T+D N L P +C
Sbjct: 209 VHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 87.4 bits (215), Expect = 2e-17
Identities = 56/201 (27%), Positives = 107/201 (53%), Gaps = 4/201 (1%)
Query: 13 RLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYL 72
+++ + L+++ L P + K + L YL+ M +N + ++ +++ L +L L
Sbjct: 205 QIQNLRELWMDNNALQVLPGSIGKLKMLVYLD---MSKNRIETVDMDISG-CEALEDLLL 260
Query: 73 HSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGD 132
SN + +P++IG L KL L + DN L ++ IG L L + N+L+ LP +G
Sbjct: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY 320
Query: 133 LKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRL 192
L L+TL + N L LP + C ++ +++ N+L ++P + Q+ L L+++ NRL
Sbjct: 321 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL 380
Query: 193 AFLPLDLGRSRELQYVYVDNN 213
LP + +EL +++ +N
Sbjct: 381 KNLPFSFTKLKELAALWLSDN 401
Score = 84.7 bits (208), Expect = 1e-16
Identities = 63/216 (29%), Positives = 107/216 (49%), Gaps = 5/216 (2%)
Query: 10 SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVE 69
++A L K L ++ + FP + + L +E N ++ LP+ Q L NL +
Sbjct: 87 TIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASV---NPISKLPDGFTQLL-NLTQ 142
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
LYL+ + +P G LVKL+ L+L +N L+ + + +L L L L NN+ LP
Sbjct: 143 LYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEV 202
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+ ++ L+ L + N L LP + L YL + +NR+ V + +L +L ++
Sbjct: 203 LDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSS 262
Query: 190 NRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYN 225
N L LP +G ++L + VD+N L LP+ + N
Sbjct: 263 NMLQQLPDSIGLLKKLTTLKVDDN-QLTMLPNTIGN 297
Score = 83.6 bits (205), Expect = 3e-16
Identities = 57/194 (29%), Positives = 101/194 (52%), Gaps = 4/194 (2%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L+LN L P + L+ LE ++ N L +LP+++ KL L L L +N
Sbjct: 143 LYLNDAFLEFLPANFGRLVKLRILE---LRENHLKTLPKSM-HKLAQLERLDLGNNEFGE 198
Query: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
+PE + + L+ L + +NAL+++ IG+L+ L +L ++ N+++ + ++ + L+ L
Sbjct: 199 LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDL 258
Query: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
+S+N L LP+ + + L L VD N+L +P + L L E + N L LP +
Sbjct: 259 LLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTI 318
Query: 200 GRSRELQYVYVDNN 213
G L+ + VD N
Sbjct: 319 GYLHSLRTLAVDEN 332
Score = 78.6 bits (192), Expect = 8e-15
Identities = 53/160 (33%), Positives = 82/160 (51%), Gaps = 2/160 (1%)
Query: 39 GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDN 98
G + LE L + N L LP+++ L L L + N + ++P IG+L L+ D S N
Sbjct: 251 GCEALEDLLLSSNMLQQLPDSIGL-LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCN 309
Query: 99 ALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLS 158
LE + IG L +LR L + N L LP E+G K + + + +N+L LPE +
Sbjct: 310 ELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQK 369
Query: 159 LQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNR-LAFLPL 197
L+ L + NRL +P +L L L ++ N+ A +PL
Sbjct: 370 LRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPL 409
Score = 77.8 bits (190), Expect = 1e-14
Identities = 63/211 (29%), Positives = 98/211 (46%), Gaps = 26/211 (12%)
Query: 26 NLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIG 85
+L P E+ E + LE LY+ N + LP+ L L +L + N++ +P I
Sbjct: 33 SLQQVPKEVFNFE--RTLEELYLDANQIEELPKQLFN-CQALRKLSIPDNDLSNLPTTIA 89
Query: 86 SLVKLQCLDLSDNALE-----IVCPE------------------IGRLRALRHLRLANNQ 122
SLV L+ LD+S N ++ I C + +L L L L +
Sbjct: 90 SLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAF 149
Query: 123 LQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSL 182
L+FLP G L +L+ L++ N L TLP+ +H L+ L + N +P L Q+ +L
Sbjct: 150 LEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 209
Query: 183 NELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
EL M N L LP +G+ + L Y+ + N
Sbjct: 210 RELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
Score = 65.1 bits (157), Expect = 1e-10
Identities = 47/154 (30%), Positives = 73/154 (47%), Gaps = 1/154 (0%)
Query: 71 YLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEV 130
Y H + V E L+ L L N +E + ++ +ALR L + +N L LP +
Sbjct: 29 YSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTI 88
Query: 131 GDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGN 190
L L+ LDIS N + PE + C L + N + +P QL +L +L +
Sbjct: 89 ASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDA 148
Query: 191 RLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLY 224
L FLP + GR +L+ + + N HLK LP ++
Sbjct: 149 FLEFLPANFGRLVKLRILELREN-HLKTLPKSMH 181
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/231 (29%), Positives = 115/231 (49%), Gaps = 7/231 (3%)
Query: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
S+L ++ ++ K+L L +L P + L L L ++ N+L ++ E ++
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS---LNNLHELDLRENNLKTVEEIISF 629
Query: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Q L NL L L NNI +P IG+L L+ L L N +E + ++ L +L L+ N
Sbjct: 630 QHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
L F+P E+ L LQ ++ N + LP+ L C LQ L + +N L + H+ +L +
Sbjct: 690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQ--YVYVDNNIHLKGLPSYLYNKVIGC 230
L L + GN L LP +L + L+ + V+ N+ L LP + ++ C
Sbjct: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENL-LNTLPLPVTERLQTC 799
Score = 78.2 bits (191), Expect = 1e-14
Identities = 66/233 (28%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 11 VARLEKHKNLFLNY----RNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLP- 65
V L+ K L+L+ L LE +D L+ L LY+K +SL+ +P+ + LP
Sbjct: 506 VFHLKNLKELYLSGCVLPEQLSTMQLEGFQD--LKNLRTLYLK-SSLSRIPQVVTDLLPS 562
Query: 66 -----------------------NLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
NL L L S ++ +P +I SL L LDL +N L+
Sbjct: 563 LQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKT 622
Query: 103 VCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
V I L+ L L+L +N + ++P ++G L L+ L + N + LP +L +C L
Sbjct: 623 VEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLH 682
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
YL + N L ++P + L +L ++ N + LP L + ++LQ + + N
Sbjct: 683 YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKN 735
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 87.4 bits (215), Expect = 2e-17
Identities = 69/231 (29%), Positives = 115/231 (49%), Gaps = 7/231 (3%)
Query: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
S+L ++ ++ K+L L +L P + L L L ++ N+L ++ E ++
Sbjct: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS---LNNLHELDLRENNLKTVEEIISF 629
Query: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Q L NL L L NNI +P IG+L L+ L L N +E + ++ L +L L+ N
Sbjct: 630 QHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689
Query: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
L F+P E+ L LQ ++ N + LP+ L C LQ L + +N L + H+ +L +
Sbjct: 690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
Query: 182 LNELSMAGNRLAFLPLDLGRSRELQ--YVYVDNNIHLKGLPSYLYNKVIGC 230
L L + GN L LP +L + L+ + V+ N+ L LP + ++ C
Sbjct: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENL-LNTLPLPVTERLQTC 799
Score = 78.2 bits (191), Expect = 1e-14
Identities = 66/233 (28%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 11 VARLEKHKNLFLNY----RNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLP- 65
V L+ K L+L+ L LE +D L+ L LY+K +SL+ +P+ + LP
Sbjct: 506 VFHLKNLKELYLSGCVLPEQLSTMQLEGFQD--LKNLRTLYLK-SSLSRIPQVVTDLLPS 562
Query: 66 -----------------------NLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
NL L L S ++ +P +I SL L LDL +N L+
Sbjct: 563 LQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKT 622
Query: 103 VCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ 160
V I L+ L L+L +N + ++P ++G L L+ L + N + LP +L +C L
Sbjct: 623 VEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLH 682
Query: 161 YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
YL + N L ++P + L +L ++ N + LP L + ++LQ + + N
Sbjct: 683 YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKN 735
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 87.0 bits (214), Expect = 2e-17
Identities = 81/247 (32%), Positives = 117/247 (47%), Gaps = 41/247 (16%)
Query: 56 LPENLAQKLPNLVELYLHSNNIVVVPEAIGSLV-------------------------KL 90
LP NL ++ L L +N + VPE +GS + L
Sbjct: 58 LPANLG----DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 91 QCLDLSDNALEIVCPE-IGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTL 149
LD+S N L + E + LR LR L L++NQL LP ++G L L+ LD+S NRL L
Sbjct: 114 TELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
Query: 150 PERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVY 209
P+ L L+ L VD N+L PR L QL +L EL ++ NRL LP D+ R L+ ++
Sbjct: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILW 233
Query: 210 VDNNIHLKGLP------SYLYNKVIGCSGCGA-PIQVS---EVKLLSFSSGQRTVFLPAE 259
+ + L LP + L + ++ +G A P Q S +K+L+ SS F A
Sbjct: 234 L-SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAAL 292
Query: 260 VKAIGTE 266
+ G E
Sbjct: 293 LPLAGLE 299
Score = 82.4 bits (202), Expect = 6e-16
Identities = 65/219 (29%), Positives = 111/219 (50%), Gaps = 12/219 (5%)
Query: 10 SVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVE 69
S++ L + + L +++ L FP +LL+ L LE L + N L LPE+++ L L
Sbjct: 176 SLSCLSRLRTLDVDHNQLTAFPRQLLQ---LVALEELDVSSNRLRGLPEDISA-LRALKI 231
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
L+L + +P L L+ L L +N L+ + + L+ L+ L L++N + P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+ L L+ L +S N+L ++P + L L +D NR+ Y+P + +L L EL + G
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 190 NRLAFLPLDLGR-SRELQYVYVDN-------NIHLKGLP 220
N++A LP G+ SR + DN + +KG+P
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIP 390
Score = 82.0 bits (201), Expect = 8e-16
Identities = 54/173 (31%), Positives = 87/173 (50%)
Query: 42 YLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
+L L + N LT+L + L L +L L N + +P +G+L L+ LD+S N L
Sbjct: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 102 IVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQY 161
+ + L LR L + +NQL P ++ L L+ LD+S+NRL LPE + +L+
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 162 LTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNI 214
L + L +P C+L SL L + N L LP + L+ + + +N+
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284
Score = 74.7 bits (182), Expect = 1e-13
Identities = 62/215 (28%), Positives = 106/215 (49%), Gaps = 5/215 (2%)
Query: 10 SVARLEKH-KNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
+VA L H L +++ L E++ L+ L +L + N L +LP L L +L
Sbjct: 105 AVAELGHHLTELDVSHNRLTALGAEVVS--ALRELRKLNLSHNQLPALPAQLGA-LAHLE 161
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
EL + N + +P+++ L +L+ LD+ N L ++ +L AL L +++N+L+ LP
Sbjct: 162 ELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPE 221
Query: 129 EVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMA 188
++ L+ L+ L +S L TLP SL+ L +D N L +P L L L+++
Sbjct: 222 DISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLS 281
Query: 189 GNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
N P L L+ +Y+ N L +PS +
Sbjct: 282 SNLFEEFPAALLPLAGLEELYLSRN-QLTSVPSLI 315
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 85.9 bits (211), Expect = 5e-17
Identities = 56/181 (30%), Positives = 94/181 (51%), Gaps = 3/181 (1%)
Query: 46 LYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCP 105
L +++ +LP +L KL L E LH ++ +PE IG L LDLS N + + P
Sbjct: 65 LKIEKEEWKTLPSSLL-KLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
Query: 106 EIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNR-LLTLPERLHMCLSLQYLTV 164
IG L L+ L L+ N+++ +P E+ + L+ L+++ NR + LP+ L L L +L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
Query: 165 DRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLY 224
N +P + +P+L L M N+L LP + R + L +++ N + LP +
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN-EITCLPQTIS 242
Query: 225 N 225
N
Sbjct: 243 N 243
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/179 (29%), Positives = 93/179 (51%), Gaps = 3/179 (1%)
Query: 41 QYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNAL 100
Q L L + RN+++ +P + L L EL L N I VP+ + + L+ L+L+ N
Sbjct: 106 QNLIVLDLSRNTISEIPPGIGL-LTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRD 164
Query: 101 EIVCP-EIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
P E+ L L HL L+ N +P V ++ L+ LD+ +N+L LP+ + +L
Sbjct: 165 ICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNL 224
Query: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYV-YVDNNIHLK 217
L + RN + +P+ + + +L L ++ N+L +P+ + L++V + DN + LK
Sbjct: 225 HTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLK 283
Score = 40.0 bits (92), Expect = 0.003
Identities = 23/73 (31%), Positives = 42/73 (57%), Gaps = 3/73 (4%)
Query: 32 LELLKD--EGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVK 89
LE L D E +Q L L+++RN +T LP+ ++ + NL L L +N + +P + +
Sbjct: 211 LEQLPDTIERMQNLHTLWLQRNEITCLPQTIS-NMKNLGTLVLSNNKLQDIPVCMEEMAN 269
Query: 90 LQCLDLSDNALEI 102
L+ ++ DN L++
Sbjct: 270 LRFVNFRDNPLKL 282
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 85.5 bits (210), Expect = 7e-17
Identities = 58/166 (34%), Positives = 92/166 (55%), Gaps = 3/166 (1%)
Query: 48 MKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEI 107
+ RN T +P ++ P L L L+ N I +PEAI +L L L++S N L + +
Sbjct: 118 LSRNRFTEIPSDVWLFAP-LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYL 176
Query: 108 GRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRN 167
L L+ L ++NN+L +P E+G LK+L LDIS N + LP+++ SL+ L + RN
Sbjct: 177 FDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRN 235
Query: 168 RLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
L +P L LP L +L + N++ +P+ + LQ + +DNN
Sbjct: 236 NLHVLPDELGDLP-LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNN 280
Score = 84.0 bits (206), Expect = 2e-16
Identities = 55/154 (35%), Positives = 86/154 (55%), Gaps = 5/154 (3%)
Query: 26 NLHHFPLELLKD--EGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEA 83
NL+H ++ + + + LQ L L + RN L++LP+ L LP L L + +N +V +PE
Sbjct: 140 NLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFD-LP-LKVLVVSNNKLVSIPEE 197
Query: 84 IGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
IG L L LD+S N ++++ ++G+L +LR L + N L LP E+GDL L LD S
Sbjct: 198 IGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSC 256
Query: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
N++ +P LQ + +D N L P +C
Sbjct: 257 NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQIC 290
Score = 42.4 bits (98), Expect = 7e-04
Identities = 31/121 (25%), Positives = 54/121 (44%), Gaps = 24/121 (19%)
Query: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNR-----------------------LLTLPER 152
L L+ +L+ P DL + D+S NR + T+PE
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
Query: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDN 212
+ L YL + RN L +P++L LP L L ++ N+L +P ++G+ ++L + +
Sbjct: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211
Query: 213 N 213
N
Sbjct: 212 N 212
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 84.7 bits (208), Expect = 1e-16
Identities = 51/130 (39%), Positives = 74/130 (56%)
Query: 70 LYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPE 129
L L N + +PEA+G+L L L ++ N L+ + P +G L L+ L L+ N L LPPE
Sbjct: 7 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 66
Query: 130 VGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
+G L L L++++NRL +LP L SL+ L + N L VP L +LP L L +
Sbjct: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
Query: 190 NRLAFLPLDL 199
N+L LP +L
Sbjct: 127 NQLRDLPPEL 136
Score = 79.3 bits (194), Expect = 5e-15
Identities = 53/138 (38%), Positives = 75/138 (54%), Gaps = 1/138 (0%)
Query: 43 LERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI 102
L L + N L+ LPE L LP L L + N + +P A+G+L LQ LDLS N L+
Sbjct: 4 LGALLLSHNCLSELPEALGA-LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62
Query: 103 VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYL 162
+ PEIG L +L L LA+N+LQ LP + L+ L+ L + +N L ++P L L L
Sbjct: 63 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 122
Query: 163 TVDRNRLWYVPRHLCQLP 180
+ N+L +P L P
Sbjct: 123 DLRDNQLRDLPPELLDAP 140
Score = 71.6 bits (174), Expect = 1e-12
Identities = 54/134 (40%), Positives = 70/134 (52%), Gaps = 1/134 (0%)
Query: 90 LQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTL 149
L L LS N L + +G L AL L + +N+LQ LPP +G L LQ LD+S N L TL
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 150 PERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVY 209
P + SL L + NRL +P L L SL L + N LA +P DL R L +
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 210 VDNNIHLKGLPSYL 223
+ +N L+ LP L
Sbjct: 124 LRDN-QLRDLPPEL 136
Score = 61.6 bits (148), Expect = 1e-09
Identities = 43/114 (37%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Query: 110 LRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRL 169
+R L L L++N L LP +G L L L ++ NRL TLP L +LQ L + +N L
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 170 WYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
+P + L SL EL++A NRL LP L R L+ + + +N+ L +P+ L
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNL-LASVPADL 113
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 84.7 bits (208), Expect = 1e-16
Identities = 72/236 (30%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 11 VARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVEL 70
+ L + ++ NL P L + L L+ + N L S+P++ A+ L + E+
Sbjct: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD---LSHNLLHSIPKSFAE-LRKMTEI 262
Query: 71 YLHSNNIVVVPEAI--------------------GS---LVKLQCLDLSDNALEIVCPEI 107
L N + VP I GS LV L+ LDLS N L +I
Sbjct: 263 GLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQI 322
Query: 108 GRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRN 167
L+ L L L +N++ LP E+G L +L+ L ++ N L+ PE + SL+ L + ++
Sbjct: 323 CALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQD 382
Query: 168 ---RLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLP 220
+L YVP H+ +L SL EL + N L +LP+ LG L+ + +N+ LK LP
Sbjct: 383 QGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNL-LKQLP 437
Score = 81.6 bits (200), Expect = 1e-15
Identities = 54/208 (25%), Positives = 97/208 (46%), Gaps = 4/208 (1%)
Query: 6 CKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLP 65
C + K + ++L FP EL L LE + + N + ++PE + L
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCV---LYTLEIIDLDENKIGAIPEEIGH-LT 211
Query: 66 NLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQF 125
L + Y+ SNN+ V+P ++ +L LDLS N L + LR + + L+ N+L+
Sbjct: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEK 271
Query: 126 LPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNEL 185
+P + L L + L L ++L++L + +N L + P +C L +L L
Sbjct: 272 VPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVL 331
Query: 186 SMAGNRLAFLPLDLGRSRELQYVYVDNN 213
+ N++ LP +LG +L+ + + N
Sbjct: 332 GLDDNKIGQLPSELGSLSKLKILGLTGN 359
Score = 79.7 bits (195), Expect = 4e-15
Identities = 58/208 (27%), Positives = 100/208 (48%), Gaps = 4/208 (1%)
Query: 5 LCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKL 64
LC + + L ++L L+Y + F L+ L L L + + L +P + + L
Sbjct: 86 LCPALGL--LSSLESLDLSYNPI--FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNL 141
Query: 65 PNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQ 124
+L L L N++ +P+ I + KL+ + L N E+ E+ L L + L N++
Sbjct: 142 HHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIG 201
Query: 125 FLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNE 184
+P E+G L LQ +++N L LP L C L L + N L +P+ +L + E
Sbjct: 202 AIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTE 261
Query: 185 LSMAGNRLAFLPLDLGRSRELQYVYVDN 212
+ ++GNRL +P + R L +Y+ N
Sbjct: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGN 289
Score = 78.2 bits (191), Expect = 1e-14
Identities = 59/198 (29%), Positives = 98/198 (49%), Gaps = 8/198 (4%)
Query: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
L L+ +LHH PL++ L+ LE L + N + LP L L L L L N +
Sbjct: 308 LDLSQNHLHHCPLQIC---ALKNLEVLGLDDNKIGQLPSELGS-LSKLKILGLTGNEFLS 363
Query: 80 VPEAIGSLVKLQCLDLSDNA---LEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKEL 136
PE + SL L+ L + + L V I +L++L+ L + NN L++LP +G + L
Sbjct: 364 FPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNL 423
Query: 137 QTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLP 196
+ LD N L LP+ + +L+ L ++ N L ++P +L L +L L++ N + P
Sbjct: 424 EVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
Query: 197 LDL-GRSRELQYVYVDNN 213
++ E + Y+ N
Sbjct: 484 KEVCAEGNEAIWKYLKEN 501
Score = 76.3 bits (186), Expect = 4e-14
Identities = 56/215 (26%), Positives = 100/215 (46%), Gaps = 29/215 (13%)
Query: 25 RNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAI 84
++L PLE+ LE ++++ N + +P+ + Q+L N+ LYL NN+ + A+
Sbjct: 35 QSLTAIPLEIFT---FTELEEVHLENNQIEEIPQEI-QRLKNIRVLYLDKNNLRSLCPAL 90
Query: 85 GSLVKLQCLDLSDNAL-EIVCPEIGRLRALRHLRL------------------------A 119
G L L+ LDLS N + + L ALR LRL
Sbjct: 91 GLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLT 150
Query: 120 NNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQL 179
N L+ LP E+ + +L+ + + N+ P+ L + +L+ + +D N++ +P + L
Sbjct: 151 GNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHL 210
Query: 180 PSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNI 214
L + MA N L LP L + +L + + +N+
Sbjct: 211 TGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNL 245
Score = 68.6 bits (166), Expect = 9e-12
Identities = 54/163 (33%), Positives = 87/163 (53%), Gaps = 14/163 (8%)
Query: 14 LEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNS---LTSLPENLAQKLPNLVEL 70
L K K L L FP E+L L LE+LY+ ++ LT +PE++ +KL +L EL
Sbjct: 348 LSKLKILGLTGNEFLSFPEEVLS---LASLEKLYIGQDQGFKLTYVPEHI-RKLQSLKEL 403
Query: 71 YLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEV 130
Y+ +N++ +P ++GS+ L+ LD N L+ + I + +AL+ LRL +N L LP +
Sbjct: 404 YIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
Query: 131 GDLKELQTLDISTNRLLTLPERLHMCLS-----LQYLTVDRNR 168
L L+ L + N + P+ +C +YL +RNR
Sbjct: 464 DSLVNLKVLTLMDNPMEEPPK--EVCAEGNEAIWKYLKENRNR 504
Score = 68.2 bits (165), Expect = 1e-11
Identities = 57/206 (27%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 11 VARLEKHKNLFLNYRNLHHF--PLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
+ RL+ + L+L+ NL L LL LE L + N + S + L L
Sbjct: 67 IQRLKNIRVLYLDKNNLRSLCPALGLLSS-----LESLDLSYNPIFSSSLVVVSFLHALR 121
Query: 69 ELYLHSNNIVVVPEAI-GSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLP 127
EL L+ ++ +P I +L L+ L L+ N L+ + EI LR + L NQ + P
Sbjct: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 128 PEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSM 187
E+ L L+ +D+ N++ +PE + LQ + N L +P LCQ L+ L +
Sbjct: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
Query: 188 AGNRLAFLPLDLGRSRELQYVYVDNN 213
+ N L +P R++ + + N
Sbjct: 242 SHNLLHSIPKSFAELRKMTEIGLSGN 267
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/218 (29%), Positives = 101/218 (46%), Gaps = 21/218 (9%)
Query: 9 ISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLV 68
+S RLEK L + +LH L L + GL L + + L NL
Sbjct: 264 LSGNRLEKVPRLICRWTSLH---LLYLGNTGLHRLRGSF--------------RCLVNLR 306
Query: 69 ELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPP 128
L L N++ P I +L L+ L L DN + + E+G L L+ L L N+ P
Sbjct: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
Query: 129 EVGDLKELQTLDISTN---RLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNEL 185
EV L L+ L I + +L +PE + SL+ L ++ N L Y+P L +P+L L
Sbjct: 367 EVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVL 426
Query: 186 SMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223
N L LP + +++ L+ + +++N+ L LP L
Sbjct: 427 DCRHNLLKQLPDAICQAQALKELRLEDNL-LTHLPENL 463
Score = 55.8 bits (133), Expect = 6e-08
Identities = 41/144 (28%), Positives = 70/144 (48%), Gaps = 6/144 (4%)
Query: 74 SNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDL 133
+ ++ +P I + +L+ + L +N +E + EI RL+ +R L L N L+ L P +G L
Sbjct: 34 NQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLL 93
Query: 134 KELQTLDISTNRL----LTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAG 189
L++LD+S N + L + LH L+ D + V L L L + G
Sbjct: 94 SSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVV--IFKNLHHLELLGLTG 151
Query: 190 NRLAFLPLDLGRSRELQYVYVDNN 213
N L LP ++ +L+ +Y+ N
Sbjct: 152 NHLKCLPKEIVNQTKLREIYLKRN 175
Score = 45.8 bits (107), Expect = 6e-05
Identities = 37/136 (27%), Positives = 68/136 (50%), Gaps = 3/136 (2%)
Query: 93 LDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPER 152
+D S+ +L + EI L + L NNQ++ +P E+ LK ++ L + N L +L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 153 LHMCLSLQYLTVDRNRLWYVPRHLCQ-LPSLNELSMAGNRLAFLPLDLGRS-RELQYVYV 210
L + SL+ L + N ++ + L +L EL + L +P+ + ++ L+ + +
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 211 DNNIHLKGLPSYLYNK 226
N HLK LP + N+
Sbjct: 150 TGN-HLKCLPKEIVNQ 164
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/177 (34%), Positives = 92/177 (51%), Gaps = 7/177 (3%)
Query: 33 ELLKDEGLQYLERLYMKRNSLTSLPENLAQK--LPNLVELYLHSNNIVVVPEAIGSLVKL 90
ELL GL+ L + ++LP+ LAQ +L L L N VP ++ L L
Sbjct: 86 ELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRAL 145
Query: 91 QCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLP 150
Q L L N L+ + EI L++L L L N ++ +PPE+G+L L L + N++ ++P
Sbjct: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIP 205
Query: 151 ERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQY 207
+L SL+ L++ N L Y+PR + L L ELS+ GN PL + R+L Y
Sbjct: 206 PQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGN-----PLVVRFVRDLTY 257
Score = 76.6 bits (187), Expect = 3e-14
Identities = 59/191 (30%), Positives = 91/191 (47%), Gaps = 31/191 (16%)
Query: 67 LVELYLHSNNIVVVPEAIGS-LVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL-- 123
L+ L L N +V +P A+GS LQ LD+S NAL + PE+ LR LR L NN+L
Sbjct: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
Query: 124 ---------------------------QFLPPEVGDLKELQTLDISTNRLLTLPERLHMC 156
Q +P + +L+ LQTL + N+L ++P +
Sbjct: 106 PSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENL 165
Query: 157 LSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHL 216
SL+ L + N + +P L LPSLN L + N++ +P L + L+ + + NN+ L
Sbjct: 166 QSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNL-L 224
Query: 217 KGLPSYLYNKV 227
LP + N +
Sbjct: 225 TYLPREILNLI 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,122,135
Number of Sequences: 37866
Number of extensions: 637407
Number of successful extensions: 3621
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 1923
Number of HSP's gapped (non-prelim): 878
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.