Search of human proteins with 122937416

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|122937416 hypothetical protein LOC85452 [Homo sapiens]
         (762 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|122937416 hypothetical protein LOC85452 [Homo sapiens]            1506   0.0  
gi|148746195 trichohyalin [Homo sapiens]                               74   4e-13
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           68   3e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           68   3e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           68   3e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        64   4e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        64   4e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         64   4e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         64   4e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         64   4e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         64   4e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         64   4e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         64   4e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    64   5e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    64   5e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    64   5e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    64   5e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    63   9e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    63   1e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                63   1e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                63   1e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    63   1e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    62   3e-09
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        62   3e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    61   3e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    61   3e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    61   4e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    60   6e-09
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap...    58   3e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    58   4e-08

>gi|122937416 hypothetical protein LOC85452 [Homo sapiens]
          Length = 762

 Score = 1506 bits (3898), Expect = 0.0
 Identities = 762/762 (100%), Positives = 762/762 (100%)

Query: 1   MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA 60
           MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA
Sbjct: 1   MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA 60

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA 120
           DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA
Sbjct: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA 120

Query: 121 AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL 180
           AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL
Sbjct: 121 AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL 180

Query: 181 EAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK 240
           EAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK
Sbjct: 181 EAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK 240

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR
Sbjct: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300

Query: 301 KFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQ 360
           KFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQ
Sbjct: 301 KFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQ 360

Query: 361 EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISDFCKKTTVPTNTYTLDYEAA 420
           EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISDFCKKTTVPTNTYTLDYEAA
Sbjct: 361 EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISDFCKKTTVPTNTYTLDYEAA 420

Query: 421 AGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDYKPYQVPKEDVDRKPVGG 480
           AGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDYKPYQVPKEDVDRKPVGG
Sbjct: 421 AGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDYKPYQVPKEDVDRKPVGG 480

Query: 481 TKMDKDILERTVERLRSRVVHKQVVWGREFQGRPFNSKPELLHFQDFDIGKVYKKKITLV 540
           TKMDKDILERTVERLRSRVVHKQVVWGREFQGRPFNSKPELLHFQDFDIGKVYKKKITLV
Sbjct: 481 TKMDKDILERTVERLRSRVVHKQVVWGREFQGRPFNSKPELLHFQDFDIGKVYKKKITLV 540

Query: 541 NTTYTINYCKLVGVEEHLRDFIHVDFDPPGPLSAGMSCEVLVTFKPMINKDLEGNISFLA 600
           NTTYTINYCKLVGVEEHLRDFIHVDFDPPGPLSAGMSCEVLVTFKPMINKDLEGNISFLA
Sbjct: 541 NTTYTINYCKLVGVEEHLRDFIHVDFDPPGPLSAGMSCEVLVTFKPMINKDLEGNISFLA 600

Query: 601 QTGEFSVPLKCSTKKCSLSLDKELIDFGSYVVGETTSRTITLTNVGGLGTTFKFLPASEP 660
           QTGEFSVPLKCSTKKCSLSLDKELIDFGSYVVGETTSRTITLTNVGGLGTTFKFLPASEP
Sbjct: 601 QTGEFSVPLKCSTKKCSLSLDKELIDFGSYVVGETTSRTITLTNVGGLGTTFKFLPASEP 660

Query: 661 CEMDDSQSALKLSSLLTYEDKSLYDKAATSFSEQQLEGTESSQADMQSRKELEKLDKEQE 720
           CEMDDSQSALKLSSLLTYEDKSLYDKAATSFSEQQLEGTESSQADMQSRKELEKLDKEQE
Sbjct: 661 CEMDDSQSALKLSSLLTYEDKSLYDKAATSFSEQQLEGTESSQADMQSRKELEKLDKEQE 720

Query: 721 EEQPAGEPGCQAKPGWAGGEGLRAAFQGAEGPRGGLESREFS 762
           EEQPAGEPGCQAKPGWAGGEGLRAAFQGAEGPRGGLESREFS
Sbjct: 721 EEQPAGEPGCQAKPGWAGGEGLRAAFQGAEGPRGGLESREFS 762


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 99/418 (23%), Positives = 183/418 (43%), Gaps = 63/418 (15%)

Query: 16  DALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKK----KTAEDR 71
           D +  E+E  E    E     +L++ E+ +        +EL  + ++L+K    +   +R
Sbjct: 235 DRVFQEEEEKEWRKRE----TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290

Query: 72  TQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGN 131
            +    +Q L    ++  +QE    + + E R  ++RR+   +Q+E    ++  E+E   
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE---QQEERREQQLRREQEERR 347

Query: 132 MAAVGRLQAVSRR---LFAELENER-DLQSRTEAVLKESENTMWHIEIQ-EGRLEAFRTA 186
              + R Q   RR   L  E E ER + Q R E  L+  +      +++ E +L   +  
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 187 DREEVEATGRRLQVRAAEQLCREQEA---------------LGKVERNRLLRIRKSLNTQ 231
            RE+     R  Q+R  +QL REQE                L + +  R   +++   T+
Sbjct: 408 RREQ--QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465

Query: 232 K-ELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECH--------------- 275
           + E   R Q+L  D  +  +   R+LK      REQ+++ E +                 
Sbjct: 466 RHEQERRKQQLKRDQEEERRE--RWLKLEEEERREQQERREQQLRREQEERREQRLKRQE 523

Query: 276 --EYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFR 333
             E +++R+ +   L+      R+ L K +   R + E  EQR++ E++    + RD   
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE----ERRDQLL 579

Query: 334 HLVHQRRRQELEAQKRAFEE--EQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRL 389
               +RR+Q L   KR  EE  EQ+L+++E+  R+ +EE  E++ K++ P    R +L
Sbjct: 580 KREEERRQQRL---KREQEERLEQRLKREEV-ERLEQEERREQRLKREEPEEERRQQL 633



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 78/372 (20%), Positives = 157/372 (42%), Gaps = 34/372 (9%)

Query: 19  LLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLR 78
           LL+D R E +   F+ +    + + + +PG     K  + +     ++ AE   Q+   +
Sbjct: 109 LLQDRRQEEDQRRFEPR----DRQLEEEPGQRRRQKRQEQE-----RELAEGEEQS-EKQ 158

Query: 79  QNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRL 138
           + L   D+   ++EL+ ++   + R   +RR   ++ Q     E    EE  +   + R 
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQER--EERRAEEEQLQSCKGHET---EEFPDEEQLRRR 213

Query: 139 QAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRL 198
           + +  R     E ++  + R + V +E E   W       + E     + E+++    + 
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR------KRETVLRKEEEKLQEEEPQR 267

Query: 199 QVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKA 258
           Q     +L  E+E L K+ER  L R R+    Q++   R Q+L     +  +      + 
Sbjct: 268 Q----RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323

Query: 259 SLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAEL-AEQRV 317
              R  +QE++ E +       R +  +  +         LR+ Q  +R + +L  EQ++
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383

Query: 318 QAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRK 377
           + E++    +     R     RR Q+L  +++   E+Q  R+Q+     L+ E EEE+ +
Sbjct: 384 RREQQ---LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ-----LRREQEEERHE 435

Query: 378 KQHPPTSARHRL 389
           ++H       RL
Sbjct: 436 QKHEQERREQRL 447



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 101/451 (22%), Positives = 185/451 (41%), Gaps = 45/451 (9%)

Query: 64  KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
           +++  E R Q     Q L    ++  EQ+L  E+     +  R+ + L  +QQ     ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425

Query: 124 ATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSR---TEAVLKESENTMWHIEIQEGRL 180
             E+E          +   +RL  E E  RD   R   TE   +E        + +E R 
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485

Query: 181 EAFRTADREE--VEATGRRLQVRAAEQLCREQEALGKVERNRLL-RIRKSLNTQKELGLR 237
           E +   + EE   +   R  Q+R  ++  REQ    + E  RL  R+R     ++E   R
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 238 HQKLL---EDARKNHKVAVRFLKASLGRIREQE-KKEEMECHEYMRRRMDAVVALKGSIS 293
            ++LL   E+ R   +   + LK      R+Q  K+EE    + ++R  +  +  +    
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR---- 601

Query: 294 ANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAF-- 351
             R+ + + +  +R +  L  +  + E++  L +  +       Q RR++ E +++    
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 352 EEEQKLRKQEIISRILKEEAEEEKRKK---QHPPTSARHRLTLRDKTWNYISDFCKKTTV 408
           EEE++  +Q      LK E EEE+R++   +     AR R+               K+ +
Sbjct: 662 EEEEERLEQR-----LKREHEEERREQELAEEEQEQARERI---------------KSRI 701

Query: 409 PTNTYTLDYEAAAGPGPSRLLEVVSSELIQ-GDPGASSEEETLAEPEISGLWNEDYKPYQ 467
           P   + L+ EA A     R  +V S    Q G      +EE     E    W E+ + ++
Sbjct: 702 PKWQWQLESEADA-----RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756

Query: 468 VPKEDVDRKPVGGTKMDKDILERTVERLRSR 498
             +E+  R+        ++  ER  +RL +R
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 82/348 (23%), Positives = 160/348 (45%), Gaps = 38/348 (10%)

Query: 38   LQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSAL-DKMHEEQELFTE 96
            LQE ED +         +      K + +  E+R +  H      AL +++ +EQ+L  E
Sbjct: 849  LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908

Query: 97   KMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQ 156
            +     R  R++R   +++++    E   +EE   +    R +   RR       ER+ Q
Sbjct: 909  EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL----REEREKRR-----RQERERQ 959

Query: 157  SRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKV 216
             R +  L++ E  +   E ++ R +      REE E     LQ    + L  E+E   + 
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE-----LQQEEEQLLREEREKRRRQ 1014

Query: 217  ERNRLLRIRKSLNTQKELGLRHQ---KLLEDARKNHKVAVRFLKAS---LGRIREQEKKE 270
            E  R  R +  L  ++E  LR +   + L++  + ++      +     LG  RE  +++
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074

Query: 271  EMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRD 330
            E+E  +Y  R+ + +   +  +       R+ Q  +R   E  E+ +Q E++ +L + R+
Sbjct: 1075 ELE-RQY--RKEEELQQEEEQLLREEPEKRRRQERERQCRE--EEELQQEEEQLLREERE 1129

Query: 331  AFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKK 378
                   +RRRQELE   R + EE++++++E   ++L+EE E+ +R++
Sbjct: 1130 -------KRRRQELE---RQYREEEEVQQEE--EQLLREEPEKRRRQE 1165



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/347 (24%), Positives = 153/347 (44%), Gaps = 43/347 (12%)

Query: 62  KLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKM--RGELRACRQRRDL-IDKQQEA 118
           +L+++    R Q     Q L    ++  EQ+L  E+   R E +  ++RR+  + ++QE 
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453

Query: 119 VAAEIATEEEAGNMAAVGRLQAVSRR---------LFAELENERDLQSRTEAVLKESENT 169
               +  EEE        R Q + R          L  E E  R+ Q R E  L+  +  
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE- 512

Query: 170 MWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEA-----LGKVERNRLLRI 224
               E +E RL+      +EE E   +RL  R+ +QL REQE      L + E  RL + 
Sbjct: 513 ----ERREQRLKR-----QEEEERLQQRL--RSEQQLRREQEERREQLLKREEEKRLEQE 561

Query: 225 RKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDA 284
           R+    ++E   R  +LL+  R+  +   R  +    R+ ++ K+EE+E  E   RR   
Sbjct: 562 RREQRLKREQEERRDQLLK--REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619

Query: 285 VVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQEL 344
           +   +      +  L+  +  +R + +L  ++ +  ++ +    R+     + QR ++E 
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK---REEEEERLEQRLKREH 676

Query: 345 EAQKRA---FEEEQKLRKQEIISRI------LKEEAEEEKRKKQHPP 382
           E ++R     EEEQ+  ++ I SRI      L+ EA+  + K    P
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 73/328 (22%), Positives = 146/328 (44%), Gaps = 41/328 (12%)

Query: 56   LDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQ 115
            L  + ++L+++  E R +    RQ         EE++L  E+     R  R+R+   DK+
Sbjct: 906  LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965

Query: 116  QEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEI 175
             +    ++  EE               RR       ER+ + R E  L++ E  +   E 
Sbjct: 966  LQQKEEQLLGEEPE------------KRR-----RQEREKKYREEEELQQEEEQLLREER 1008

Query: 176  QEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELG 235
            ++ R + +    R++ E        +  EQL RE+      E+ RL    +    ++EL 
Sbjct: 1009 EKRRRQEWERQYRKKDELQ------QEEEQLLREER-----EKRRLQERERQYREEEELQ 1057

Query: 236  LRHQKLL---EDARKNHKVAVRFLKAS-LGRIREQEKKEEMECHEYMRRRMDAVVALKGS 291
               ++LL    + R+  ++  ++ K   L +  EQ  +EE E  +  R+  +     +  
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE--KRRRQERERQCREEEE 1115

Query: 292  ISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAF 351
            +    + L + +   R + EL  +R   E++ +  +     R    +RRRQELE   R +
Sbjct: 1116 LQQEEEQLLREEREKRRRQEL--ERQYREEEEVQQEEEQLLREEPEKRRRQELE---RQY 1170

Query: 352  EEEQKLRKQEIISRILKEEAEEEKRKKQ 379
             EE++L+++E   ++L+EE E+ +++++
Sbjct: 1171 REEEELQQEE--EQLLREEQEKRRQERE 1196



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 87/396 (21%), Positives = 162/396 (40%), Gaps = 51/396 (12%)

Query: 21   EDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQN 80
            E ER  L++ E  ++C  +E +   D       +E      +  +K  E+  Q     + 
Sbjct: 1387 ERERKFLKE-EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445

Query: 81   LSALD-----------KMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEA 129
               L+           K  EE++L  E+   +L    + R  ++++Q+     +  +E  
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ-----LRRQERD 1500

Query: 130  GNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADRE 189
                          R F E E +   Q R    L+E +                R  +R 
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ--------------LRRQERG 1546

Query: 190  EVEATGRRLQVRAAEQLC--REQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARK 247
            +     R  + R  EQL   RE++ L + ER+R  R+ +    ++E   + +K +ED ++
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE---QERKFMEDEQQ 1603

Query: 248  -NHKVAVRFLKASLGR-IREQEK----KEEMECHEYMRRRMDAVVALKGSISANRDTLRK 301
               +   + L+    R  RE E+    +EE + H   R R      L+      R    +
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK----FLEEEPQLRRQEREQ 1659

Query: 302  FQAWDRAKAELAEQRV--QAEKKAILAQGRDA-FRHLVHQRRRQELEAQKRAFEEEQKLR 358
                DR +    E+++  + E++ +  Q RD  FR    Q RRQE E  ++  +EEQ+LR
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE--RKFLQEEQQLR 1717

Query: 359  KQEIISRILKEEAEEEKRKKQHPPTSARHRLTLRDK 394
            +QE+  +  +EE   ++ +++      R+R  L ++
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 96/415 (23%), Positives = 167/415 (40%), Gaps = 71/415 (17%)

Query: 23   ERDELEDPEFDI------KCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFH 76
            ++DEL+  E  +      K  LQE E           +EL  + ++L  +  E R +   
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQY-----REEEELQQEEEQLLGEERETRRRQEL 1076

Query: 77   LRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVG 136
             RQ     +   EE++L  E+     R  R+R+   +++ +    ++  EE         
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR----- 1131

Query: 137  RLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEV---EA 193
            R Q + R    +   E ++Q   E +L+E        E++    E       EE    E 
Sbjct: 1132 RRQELER----QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 194  TGRRLQVRAAEQLCREQEALGKVERNRLLR-------IRKSLNTQKELGLRHQKL----- 241
              +R Q R  E+  RE+E L + +R +  R       ++     +KE  +R  K+     
Sbjct: 1188 QEKRRQER--ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245

Query: 242  -------LEDARKNHKVAVRFLKASLG----RIREQEKKE--------------EMECHE 276
                   LED++   + + + L+  LG    R REQE++               E E  +
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305

Query: 277  YMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLV 336
              +RR       K  +   R+  R+ Q  DR   E  +   + E++ +  Q RD      
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD------ 1359

Query: 337  HQRRRQELEAQKRA---FEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHR 388
             + R +EL  Q++     EEEQ+LR+QE   + LKEE +   ++++      R R
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 93/382 (24%), Positives = 162/382 (42%), Gaps = 67/382 (17%)

Query: 62  KLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTE---KMRGELRACRQRRDL-IDKQQE 117
           +LK++  E+R     L+Q L +  ++  EQE   E   K   E R  ++RR+  + ++QE
Sbjct: 518 RLKRQEEEER-----LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572

Query: 118 AVAAEIATEEEAGNMAAVGRLQA--VSRRLFAELENERDLQSRTEAVLKESENTMWHIEI 175
               ++   EE      + R Q   + +RL  E     + + R E  LK  E        
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE------ 626

Query: 176 QEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELG 235
           +E R +  ++ ++EE     R+ Q+R  +Q  REQ    + E  RL    + L  + E  
Sbjct: 627 EERRQQLLKSEEQEE----RRQQQLRREQQERREQRLKREEEEERL---EQRLKREHEEE 679

Query: 236 LRHQKLLED----ARKNHKVAVRFLKASL------------GRIREQEKKEEMECHEYMR 279
            R Q+L E+    AR+  K  +   +  L             R R+QE +   +  E  R
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739

Query: 280 RRMDAVVALKGSISANRDTLRKFQAWD------------------RAKAELAEQR---VQ 318
           RR ++ +  +    A+R    + Q  D                   A+  L EQR   ++
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799

Query: 319 AEKKAILAQGRDAFRHLVHQRRRQELEAQK--RAFEEEQKLRKQEIISRILKEE----AE 372
           AE++    Q          QRRRQ  E +K  +  EEE++L+++E   ++ +EE     +
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859

Query: 373 EEKRKKQHPPTSARHRLTLRDK 394
           +E+R+ Q      + R  L ++
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEE 881



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 93/374 (24%), Positives = 161/374 (43%), Gaps = 40/374 (10%)

Query: 16   DALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAF 75
            + LL E E  +L   E D K  L+E +           +E +  + + ++K  E+  Q  
Sbjct: 1467 EQLLQEREEQQLHRQERDRK-FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQ-L 1524

Query: 76   HLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAV 135
            H +Q       + EEQ+L  ++ RG+ R  RQ RD   +++E +  E   EE+       
Sbjct: 1525 HRQQRQRKF--LQEEQQLRRQE-RGQQR--RQDRDRKFREEEQLRQE--REEQ------- 1570

Query: 136  GRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATG 195
             +L    R     LE ++  +   E    E E     +  QEG+ +  +  DR+  E   
Sbjct: 1571 -QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ---QLRRQEGQQQLRQERDRKFREDE- 1625

Query: 196  RRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF 255
            + LQ R  +QL R++     +E    LR       ++E  LRH +     RK  +     
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLR-----RQEREQQLRHDR----DRKFREEEQLL 1676

Query: 256  LKASLGRIREQEKKEEMECHEYMRRRMDAVVA-LKGSISANRDTL-RKFQAWDRAKAELA 313
             +    ++R QE+  +    E   RR +     L+      R  L RKF+  ++ + E  
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736

Query: 314  EQRVQAEKK--AILAQGRDAFRHLVHQRRRQEL------EAQKRAFEEEQKLRKQEIISR 365
            +++++ +++   IL + +        Q RRQE       E Q R   EEQ+LR QE   +
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796

Query: 366  ILKEEAEEEKRKKQ 379
              +EE   ++R++Q
Sbjct: 1797 FREEEQLRQEREEQ 1810



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 77/344 (22%), Positives = 142/344 (41%), Gaps = 48/344 (13%)

Query: 63  LKKKTAEDRTQAFHLRQNLSALD---KMHEEQELFTEKMRGELRACRQRRDLIDKQQEAV 119
           LK +  E+R Q    R+     +   K  EE+E   ++++ E    R+ ++L +++QE  
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693

Query: 120 AAEIATEEEAGNMAAVGRLQAVSRRLFA---ELENERDLQSRTEAVLKESENTMWHIEIQ 176
              I +              A   ++++   + E +R  Q + E   +      W  E +
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 177 EGRLEAFRTADR--------EEVEATGRRL-------------QVRAAEQLCREQEALGK 215
             R +      R        EE    GR+              Q+RA E+  REQ  L +
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 216 VERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECH 275
            E     R R+    +KEL    +   E+  +  + A +  +   G   +QE++   E  
Sbjct: 814 EEEKEQRR-RQRREREKELQFLEE---EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869

Query: 276 EYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHL 335
              + R      L+      R TL        AK  L EQ ++ E++ +  +  +  R  
Sbjct: 870 RDQKWRWQ----LEEERKRRRHTLY-------AKPALQEQ-LRKEQQLLQEEEEELQREE 917

Query: 336 VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQ 379
             +RRRQE E   R + EE++L+++E   ++L+EE E+ +R+++
Sbjct: 918 REKRRRQEQE---RQYREEEQLQQEE--EQLLREEREKRRRQER 956



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 88/387 (22%), Positives = 147/387 (37%), Gaps = 68/387 (17%)

Query: 55   ELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDK 114
            EL  + ++L ++  E R      RQ     +   EE++L      GE R  R+R++L  +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL-----GEERETRRRQEL--E 1077

Query: 115  QQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIE 174
            +Q     E+  EEE      + R +   RR       ER+ Q R E  L++ E  +   E
Sbjct: 1078 RQYRKEEELQQEEEQ-----LLREEPEKRR-----RQERERQCREEEELQQEEEQLLREE 1127

Query: 175  IQEGRLEAFRTADREEVEATGRRLQV------------------------RAAEQLCREQ 210
             ++ R +      REE E      Q+                        +  EQL RE+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 211  EALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKV--------AVRFLKASLGR 262
            +   + ER R  R  + L  QK    + +   ED R + K         AVR  K    +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKR---KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC-K 1243

Query: 263  IREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQ------- 315
             RE E+  ++E  +   R+    +         RD  ++ + W +      E+       
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303

Query: 316  --------RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRIL 367
                    R   E+K +L + R+  R      R+   E Q     EEQ LR+QE   +  
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363

Query: 368  KEEAEEEKRKKQHPPTSARHRLTLRDK 394
            +EE   +++ ++      R R   R++
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERER 1390



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 87/353 (24%), Positives = 146/353 (41%), Gaps = 70/353 (19%)

Query: 86   KMHEEQELFTEKMRGEL-RACRQRRDLIDKQ----QEAVAAEIATEEEAGNMAAVGRLQA 140
            K  EE++L  E+   +L R  R R+  +++Q    QE     +  E++        +L+ 
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615

Query: 141  VSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQV 200
               R F E  +E+ LQ R E  L   E     +E +E +L   R  +RE+     R  + 
Sbjct: 1616 ERDRKFRE--DEQLLQEREEQQLHRQERDRKFLE-EEPQL---RRQEREQQLRHDRDRKF 1669

Query: 201  RAAEQLCRE--QEALGKVERNRLLRI---------RKSLNTQKELGLRHQKLLEDARKNH 249
            R  EQL +E  ++ L + ER+R  R          R+    Q+E  LR Q+L    R+  
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729

Query: 250  KVAVRFLKASLGR-------IREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTL--- 299
            ++     +  L R       + E++ + E E  +  R+  D     +  +   R+     
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789

Query: 300  -----RKFQAWDRAKAELAEQRVQA-----------------EKKAILAQGRDAFRHLVH 337
                 RKF+  ++ + E  EQ+++                  E++  L Q RD       
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849

Query: 338  Q--------RRRQEL---EAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQ 379
            Q        R  QEL   E QKR  E E+KLR++ I     + + +EE+R +Q
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHI-----RRQQKEEQRHRQ 1897



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 75/364 (20%), Positives = 148/364 (40%), Gaps = 53/364 (14%)

Query: 54  KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLID 113
           +E +   ++L K+  E R +     Q L    +   +Q L  E+ R + R  R++ + ++
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599

Query: 114 KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHI 173
           ++ +    E   +EE        R Q + R    E E ER  Q       +E        
Sbjct: 600 QRLKREEVERLEQEER-------REQRLKRE---EPEEERRQQLLKSEEQEERRQQQLRR 649

Query: 174 EIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSL----- 228
           E QE R +  R    EE E   +RL+ R  E+  REQE   + +     RI+  +     
Sbjct: 650 EQQERREQ--RLKREEEEERLEQRLK-REHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 229 ---------------NTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEM- 272
                            +K+ G R ++  E+ R+  +  +++ +      ++QE+++   
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 273 --------ECHEYMRRRMDAVVALKGS------ISANRDTLRKFQAWDRAKAELAEQRVQ 318
                   E  E  R+R+ A   L+            +   ++F   +  K +   QR +
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 319 AEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILK--EEAEEEKR 376
            EK+    +  +    L  + R Q+L+ ++   +E+Q+ R+ +   R  K   + EEE++
Sbjct: 827 REKELQFLEEEE---QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883

Query: 377 KKQH 380
           +++H
Sbjct: 884 RRRH 887



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 86/403 (21%), Positives = 162/403 (40%), Gaps = 85/403 (21%)

Query: 10   EDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVK----ELDTDADKLKK 65
            E+E L   L  E E +  E        L +E ++       S +     +L+++AD  + 
Sbjct: 664  EEERLEQRLKREHEEERREQE------LAEEEQEQARERIKSRIPKWQWQLESEADARQS 717

Query: 66   KTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIAT 125
            K         + R       +  +EQE    +   EL+   + R    +Q+E    +   
Sbjct: 718  KV--------YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769

Query: 126  EEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRT 185
            + +A   +  GR +  +R     L  +R+ Q R E   +  +  +   E +E R    R 
Sbjct: 770  QWQAEEKSERGRQRLSAR---PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 186  ADRE-----EVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK 240
             ++E     E E   RR     A+QL  E++ L + +  R     +S   +++   R Q 
Sbjct: 827  REKELQFLEEEEQLQRR---ERAQQLQEEEDGLQEDQERR-----RSQEQRRDQKWRWQ- 877

Query: 241  LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
             LE+ RK  +  +    A   ++R++++  + E  E  R   +                R
Sbjct: 878  -LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK---------------R 921

Query: 301  KFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQ------------- 347
            + Q  +R   E  E+++Q E++ +L + R+       +RRRQE E Q             
Sbjct: 922  RRQEQERQYRE--EEQLQQEEEQLLREERE-------KRRRQERERQYRKDKKLQQKEEQ 972

Query: 348  --------KRAFEEEQKLRKQEII----SRILKEEAEEEKRKK 378
                    +R  E E+K R++E +     ++L+EE E+ +R++
Sbjct: 973  LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 56/236 (23%), Positives = 98/236 (41%), Gaps = 24/236 (10%)

Query: 176 QEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELG 235
           QE     F   DR+  E  G+R + +  EQ     E   + E+   L  R      +EL 
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174

Query: 236 LRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
            + Q+  E  R+  +     L++  G      + EE    E +RRR    +  KG     
Sbjct: 175 RQRQEWQE--REERRAEEEQLQSCKGH-----ETEEFPDEEQLRRRELLELRRKGREEKQ 227

Query: 296 RDTL----RKFQA-----WDRAKAELA--EQRVQAE---KKAILAQGRDAFRHLVHQ--- 338
           +       R FQ      W + +  L   E+++Q E   ++  L +  +  R L  Q   
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287

Query: 339 RRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLRDK 394
           R RQE E Q++    EQ+LR+++   R  ++E   E+++++      R +   R++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 80/408 (19%), Positives = 157/408 (38%), Gaps = 28/408 (6%)

Query: 1   MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA 60
           +  +  L  E E   + LL  +E   LE    + + L +E E+  D      +K  +   
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQR-LKREQEERRD----QLLKREEERR 586

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHE----------EQELFTEKMRGELRACRQRRD 110
            +  K+  E+R +    R+ +  L++             E+E   + ++ E +  R+++ 
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 111 LIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTM 170
           L  +QQE     +  EEE   +    + +    R   EL  E   Q+R E +        
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR-ERIKSRIPKWQ 705

Query: 171 WHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNT 230
           W +E  E      +   R   +   RR Q +  ++  RE E L   E  R  R ++    
Sbjct: 706 WQLE-SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE-LQWQEEERAHRQQQEEEQ 763

Query: 231 QKELGLRHQKLLEDARKNHKVAVR---------FLKASLGRIREQEKKEEMECHEYMRRR 281
           +++   + Q   +  R   +++ R          L+A   + REQ    E E  E  RR+
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823

Query: 282 MDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFR-HLVHQRR 340
                     +       R+ +A    + E   Q  Q  +++   +    +R  L  +R+
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883

Query: 341 RQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHR 388
           R+      +   +EQ  ++Q+++    +E   EE+ K++      ++R
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 122/522 (23%), Positives = 212/522 (40%), Gaps = 50/522 (9%)

Query: 11   DELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAED 70
            +E  +  + L  E    E    D + LLQE E        S V+ ++ +A  L+++  E+
Sbjct: 1322 NEAESKTIRLSKELSSTEAQLHDAQELLQE-ETRAKLALGSRVRAMEAEAAGLREQLEEE 1380

Query: 71   RTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAG 130
                    + L        E     E+  G L A  + R    ++ EA+   +A + E  
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET- 1439

Query: 131  NMAAVGRLQAVSRRLFAELEN-ERDLQSRTEAV--LKESENTMWHIEIQEGRLEAFRTAD 187
                V RL+   RRL  EL++   DL+ + + V  L++ +     +  +E         +
Sbjct: 1440 ----VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1495

Query: 188  REEVEATGRRLQVRA---AEQLCREQEALGKVER-NRLLR--IRKSLNTQKELGLRHQKL 241
            RE  EA GR  + RA      L  EQEA  ++ER NR LR  +   L+++ ++G +    
Sbjct: 1496 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG-KSVHE 1554

Query: 242  LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV-ALKGSISANRDTLR 300
            LE A +  + A   L+A +      E ++E+   E  + R++  V ALK      RD   
Sbjct: 1555 LERACRVAEQAANDLRAQV-----TELEDELTAAEDAKLRLEVTVQALK--TQHERDLQG 1607

Query: 301  KFQAWDRAKAELAEQRVQAE--------KKAILAQGRDAFRHLVHQRRRQELEAQKRAFE 352
            + +A +  + +LA+Q   AE        ++ +    R      + + + Q   A +   E
Sbjct: 1608 RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1667

Query: 353  EEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARH---RL------TLRDKTWNYISDFC 403
              ++LRK +   + L  E EE +  ++   +  R    RL       LR +     SD  
Sbjct: 1668 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1727

Query: 404  KKTTVPTNTYTLDYEAAAGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDY 463
            ++          D  A      + +LE      ++G  G   EEE   E   S L N+ Y
Sbjct: 1728 RRQAQQDRDEMADEVANGNLSKAAILE--EKRQLEGRLG-QLEEELEEEQSNSELLNDRY 1784

Query: 464  KPYQVPKEDV------DRKPVGGTKMDKDILERTVERLRSRV 499
            +   +  E +      +R      +  +  LER ++ LR R+
Sbjct: 1785 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 86/389 (22%), Positives = 165/389 (42%), Gaps = 54/389 (13%)

Query: 34   IKCLLQEA-EDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSAL-DKMHEEQ 91
            +K LLQ   +D+V    +  ++++     +  ++  E + +   L +  + L +++  E 
Sbjct: 866  VKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 925

Query: 92   ELFTE--KMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVG--RLQAVSRRLFA 147
            EL  E  + RG L A +Q  +L+  + EA   E   EEE          RLQ   + L A
Sbjct: 926  ELCAEAEETRGRLAARKQELELVVSELEARVGE---EEECSRQMQTEKKRLQQHIQELEA 982

Query: 148  ELENERDLQSR-------TEAVLKESENTMWHIEIQEGRLEAFR-------------TAD 187
             LE E   + +       TEA +K+ E  +  +E Q  +L   R              A+
Sbjct: 983  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1042

Query: 188  REEVEATGRRLQVRAAEQLCREQEALGKVERNR--LLRIRKSLNTQKELGLRHQKLLEDA 245
             EE   +  +L+++    +   ++ L K E+ R  L ++++ L+ +    L+ Q + +  
Sbjct: 1043 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS-ELQEQMVEQQQ 1101

Query: 246  RKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAW 305
            R         L+A LGR  E+ +       +    R   + +L+ + +A  +     ++ 
Sbjct: 1102 RAEE------LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1155

Query: 306  D--RAKAELAEQRVQAEKKAILAQGRDAF-----RHLVHQRRRQELEAQKRAFEEEQKLR 358
               R KAE   + +  E +A+  +  D       +  +  +R QE+   K+  EEE ++ 
Sbjct: 1156 RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 1215

Query: 359  K---QEIISR------ILKEEAEEEKRKK 378
            +   QE+  R       L E+ E+ +R K
Sbjct: 1216 EAAVQELRQRHGQALGELAEQLEQARRGK 1244



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 99/421 (23%), Positives = 170/421 (40%), Gaps = 76/421 (18%)

Query: 20   LEDERDELEDPEFDIKCLLQEAE------DDVDPGHSSSVKELDTDADKLKKKTAED-RT 72
            LE+E++  E+ E   + L  E E      DDV      SV EL+  A ++ ++ A D R 
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDV----GKSVHELER-ACRVAEQAANDLRA 1571

Query: 73   QAFHLRQNLSALD-------------KMHEEQELFTEKMRGELRACRQRRDLIDKQQE-- 117
            Q   L   L+A +             K   E++L      GE R  +  + L D + E  
Sbjct: 1572 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1631

Query: 118  --------AVAA----EIATEEEAGNMAAVG-----------RLQAVSRRLFAELENERD 154
                    AVAA    E   EE    MA+ G           ++QA  + L+ E+E  R 
Sbjct: 1632 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1691

Query: 155  LQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGR-RLQVRAAEQLCREQEAL 213
             +    +  +ESE  +  +E +  RL+       EE+ A+ R R Q +       ++ A 
Sbjct: 1692 SREEIFSQNRESEKRLKGLEAEVLRLQ-------EELAASDRARRQAQQDRDEMADEVAN 1744

Query: 214  GKVERNRLLRIRK-------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQ 266
            G + +  +L  ++        L  + E    + +LL D  +   + V  L   L   R  
Sbjct: 1745 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1804

Query: 267  EKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQ-AWDRAKAELAEQRVQAEKKAIL 325
              K E    + + R++  +    G   A      K   A   +K   AE++++ E +  +
Sbjct: 1805 SAKAE-SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1863

Query: 326  AQGRDAFRHLVHQRRRQ---ELEAQKRAFEE-EQKLRKQEIISRILK---EEAEEEKRKK 378
              G+   R    +R ++   ++E ++R  ++   +L K  +  + LK   EEAEEE  + 
Sbjct: 1864 LSGKLVRR--AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRA 1921

Query: 379  Q 379
            Q
Sbjct: 1922 Q 1922


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 122/522 (23%), Positives = 212/522 (40%), Gaps = 50/522 (9%)

Query: 11   DELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAED 70
            +E  +  + L  E    E    D + LLQE E        S V+ ++ +A  L+++  E+
Sbjct: 1314 NEAESKTIRLSKELSSTEAQLHDAQELLQE-ETRAKLALGSRVRAMEAEAAGLREQLEEE 1372

Query: 71   RTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAG 130
                    + L        E     E+  G L A  + R    ++ EA+   +A + E  
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET- 1431

Query: 131  NMAAVGRLQAVSRRLFAELEN-ERDLQSRTEAV--LKESENTMWHIEIQEGRLEAFRTAD 187
                V RL+   RRL  EL++   DL+ + + V  L++ +     +  +E         +
Sbjct: 1432 ----VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1487

Query: 188  REEVEATGRRLQVRA---AEQLCREQEALGKVER-NRLLR--IRKSLNTQKELGLRHQKL 241
            RE  EA GR  + RA      L  EQEA  ++ER NR LR  +   L+++ ++G +    
Sbjct: 1488 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG-KSVHE 1546

Query: 242  LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV-ALKGSISANRDTLR 300
            LE A +  + A   L+A +      E ++E+   E  + R++  V ALK      RD   
Sbjct: 1547 LERACRVAEQAANDLRAQV-----TELEDELTAAEDAKLRLEVTVQALK--TQHERDLQG 1599

Query: 301  KFQAWDRAKAELAEQRVQAE--------KKAILAQGRDAFRHLVHQRRRQELEAQKRAFE 352
            + +A +  + +LA+Q   AE        ++ +    R      + + + Q   A +   E
Sbjct: 1600 RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1659

Query: 353  EEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARH---RL------TLRDKTWNYISDFC 403
              ++LRK +   + L  E EE +  ++   +  R    RL       LR +     SD  
Sbjct: 1660 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1719

Query: 404  KKTTVPTNTYTLDYEAAAGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDY 463
            ++          D  A      + +LE      ++G  G   EEE   E   S L N+ Y
Sbjct: 1720 RRQAQQDRDEMADEVANGNLSKAAILE--EKRQLEGRLG-QLEEELEEEQSNSELLNDRY 1776

Query: 464  KPYQVPKEDV------DRKPVGGTKMDKDILERTVERLRSRV 499
            +   +  E +      +R      +  +  LER ++ LR R+
Sbjct: 1777 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 86/389 (22%), Positives = 165/389 (42%), Gaps = 54/389 (13%)

Query: 34   IKCLLQEA-EDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSAL-DKMHEEQ 91
            +K LLQ   +D+V    +  ++++     +  ++  E + +   L +  + L +++  E 
Sbjct: 858  VKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 917

Query: 92   ELFTE--KMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVG--RLQAVSRRLFA 147
            EL  E  + RG L A +Q  +L+  + EA   E   EEE          RLQ   + L A
Sbjct: 918  ELCAEAEETRGRLAARKQELELVVSELEARVGE---EEECSRQMQTEKKRLQQHIQELEA 974

Query: 148  ELENERDLQSR-------TEAVLKESENTMWHIEIQEGRLEAFR-------------TAD 187
             LE E   + +       TEA +K+ E  +  +E Q  +L   R              A+
Sbjct: 975  HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1034

Query: 188  REEVEATGRRLQVRAAEQLCREQEALGKVERNR--LLRIRKSLNTQKELGLRHQKLLEDA 245
             EE   +  +L+++    +   ++ L K E+ R  L ++++ L+ +    L+ Q + +  
Sbjct: 1035 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS-ELQEQMVEQQQ 1093

Query: 246  RKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAW 305
            R         L+A LGR  E+ +       +    R   + +L+ + +A  +     ++ 
Sbjct: 1094 RAEE------LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1147

Query: 306  D--RAKAELAEQRVQAEKKAILAQGRDAF-----RHLVHQRRRQELEAQKRAFEEEQKLR 358
               R KAE   + +  E +A+  +  D       +  +  +R QE+   K+  EEE ++ 
Sbjct: 1148 RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 1207

Query: 359  K---QEIISR------ILKEEAEEEKRKK 378
            +   QE+  R       L E+ E+ +R K
Sbjct: 1208 EAAVQELRQRHGQALGELAEQLEQARRGK 1236



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 99/421 (23%), Positives = 170/421 (40%), Gaps = 76/421 (18%)

Query: 20   LEDERDELEDPEFDIKCLLQEAE------DDVDPGHSSSVKELDTDADKLKKKTAED-RT 72
            LE+E++  E+ E   + L  E E      DDV      SV EL+  A ++ ++ A D R 
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDV----GKSVHELER-ACRVAEQAANDLRA 1563

Query: 73   QAFHLRQNLSALD-------------KMHEEQELFTEKMRGELRACRQRRDLIDKQQE-- 117
            Q   L   L+A +             K   E++L      GE R  +  + L D + E  
Sbjct: 1564 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1623

Query: 118  --------AVAA----EIATEEEAGNMAAVG-----------RLQAVSRRLFAELENERD 154
                    AVAA    E   EE    MA+ G           ++QA  + L+ E+E  R 
Sbjct: 1624 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1683

Query: 155  LQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGR-RLQVRAAEQLCREQEAL 213
             +    +  +ESE  +  +E +  RL+       EE+ A+ R R Q +       ++ A 
Sbjct: 1684 SREEIFSQNRESEKRLKGLEAEVLRLQ-------EELAASDRARRQAQQDRDEMADEVAN 1736

Query: 214  GKVERNRLLRIRK-------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQ 266
            G + +  +L  ++        L  + E    + +LL D  +   + V  L   L   R  
Sbjct: 1737 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1796

Query: 267  EKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQ-AWDRAKAELAEQRVQAEKKAIL 325
              K E    + + R++  +    G   A      K   A   +K   AE++++ E +  +
Sbjct: 1797 SAKAE-SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1855

Query: 326  AQGRDAFRHLVHQRRRQ---ELEAQKRAFEE-EQKLRKQEIISRILK---EEAEEEKRKK 378
              G+   R    +R ++   ++E ++R  ++   +L K  +  + LK   EEAEEE  + 
Sbjct: 1856 LSGKLVRR--AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRA 1913

Query: 379  Q 379
            Q
Sbjct: 1914 Q 1914


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 122/522 (23%), Positives = 212/522 (40%), Gaps = 50/522 (9%)

Query: 11   DELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAED 70
            +E  +  + L  E    E    D + LLQE E        S V+ ++ +A  L+++  E+
Sbjct: 1355 NEAESKTIRLSKELSSTEAQLHDAQELLQE-ETRAKLALGSRVRAMEAEAAGLREQLEEE 1413

Query: 71   RTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAG 130
                    + L        E     E+  G L A  + R    ++ EA+   +A + E  
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTET- 1472

Query: 131  NMAAVGRLQAVSRRLFAELEN-ERDLQSRTEAV--LKESENTMWHIEIQEGRLEAFRTAD 187
                V RL+   RRL  EL++   DL+ + + V  L++ +     +  +E         +
Sbjct: 1473 ----VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEE 1528

Query: 188  REEVEATGRRLQVRA---AEQLCREQEALGKVER-NRLLR--IRKSLNTQKELGLRHQKL 241
            RE  EA GR  + RA      L  EQEA  ++ER NR LR  +   L+++ ++G +    
Sbjct: 1529 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG-KSVHE 1587

Query: 242  LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV-ALKGSISANRDTLR 300
            LE A +  + A   L+A +      E ++E+   E  + R++  V ALK      RD   
Sbjct: 1588 LERACRVAEQAANDLRAQV-----TELEDELTAAEDAKLRLEVTVQALK--TQHERDLQG 1640

Query: 301  KFQAWDRAKAELAEQRVQAE--------KKAILAQGRDAFRHLVHQRRRQELEAQKRAFE 352
            + +A +  + +LA+Q   AE        ++ +    R      + + + Q   A +   E
Sbjct: 1641 RDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1700

Query: 353  EEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARH---RL------TLRDKTWNYISDFC 403
              ++LRK +   + L  E EE +  ++   +  R    RL       LR +     SD  
Sbjct: 1701 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1760

Query: 404  KKTTVPTNTYTLDYEAAAGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDY 463
            ++          D  A      + +LE      ++G  G   EEE   E   S L N+ Y
Sbjct: 1761 RRQAQQDRDEMADEVANGNLSKAAILE--EKRQLEGRLG-QLEEELEEEQSNSELLNDRY 1817

Query: 464  KPYQVPKEDV------DRKPVGGTKMDKDILERTVERLRSRV 499
            +   +  E +      +R      +  +  LER ++ LR R+
Sbjct: 1818 RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 86/389 (22%), Positives = 165/389 (42%), Gaps = 54/389 (13%)

Query: 34   IKCLLQEA-EDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSAL-DKMHEEQ 91
            +K LLQ   +D+V    +  ++++     +  ++  E + +   L +  + L +++  E 
Sbjct: 899  VKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEA 958

Query: 92   ELFTE--KMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVG--RLQAVSRRLFA 147
            EL  E  + RG L A +Q  +L+  + EA   E   EEE          RLQ   + L A
Sbjct: 959  ELCAEAEETRGRLAARKQELELVVSELEARVGE---EEECSRQMQTEKKRLQQHIQELEA 1015

Query: 148  ELENERDLQSR-------TEAVLKESENTMWHIEIQEGRLEAFR-------------TAD 187
             LE E   + +       TEA +K+ E  +  +E Q  +L   R              A+
Sbjct: 1016 HLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1075

Query: 188  REEVEATGRRLQVRAAEQLCREQEALGKVERNR--LLRIRKSLNTQKELGLRHQKLLEDA 245
             EE   +  +L+++    +   ++ L K E+ R  L ++++ L+ +    L+ Q + +  
Sbjct: 1076 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESS-ELQEQMVEQQQ 1134

Query: 246  RKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAW 305
            R         L+A LGR  E+ +       +    R   + +L+ + +A  +     ++ 
Sbjct: 1135 RAEE------LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESE 1188

Query: 306  D--RAKAELAEQRVQAEKKAILAQGRDAF-----RHLVHQRRRQELEAQKRAFEEEQKLR 358
               R KAE   + +  E +A+  +  D       +  +  +R QE+   K+  EEE ++ 
Sbjct: 1189 RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIH 1248

Query: 359  K---QEIISR------ILKEEAEEEKRKK 378
            +   QE+  R       L E+ E+ +R K
Sbjct: 1249 EAAVQELRQRHGQALGELAEQLEQARRGK 1277



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 99/421 (23%), Positives = 170/421 (40%), Gaps = 76/421 (18%)

Query: 20   LEDERDELEDPEFDIKCLLQEAE------DDVDPGHSSSVKELDTDADKLKKKTAED-RT 72
            LE+E++  E+ E   + L  E E      DDV      SV EL+  A ++ ++ A D R 
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDV----GKSVHELER-ACRVAEQAANDLRA 1604

Query: 73   QAFHLRQNLSALD-------------KMHEEQELFTEKMRGELRACRQRRDLIDKQQE-- 117
            Q   L   L+A +             K   E++L      GE R  +  + L D + E  
Sbjct: 1605 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1664

Query: 118  --------AVAA----EIATEEEAGNMAAVG-----------RLQAVSRRLFAELENERD 154
                    AVAA    E   EE    MA+ G           ++QA  + L+ E+E  R 
Sbjct: 1665 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1724

Query: 155  LQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGR-RLQVRAAEQLCREQEAL 213
             +    +  +ESE  +  +E +  RL+       EE+ A+ R R Q +       ++ A 
Sbjct: 1725 SREEIFSQNRESEKRLKGLEAEVLRLQ-------EELAASDRARRQAQQDRDEMADEVAN 1777

Query: 214  GKVERNRLLRIRK-------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQ 266
            G + +  +L  ++        L  + E    + +LL D  +   + V  L   L   R  
Sbjct: 1778 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1837

Query: 267  EKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQ-AWDRAKAELAEQRVQAEKKAIL 325
              K E    + + R++  +    G   A      K   A   +K   AE++++ E +  +
Sbjct: 1838 SAKAE-SGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1896

Query: 326  AQGRDAFRHLVHQRRRQ---ELEAQKRAFEE-EQKLRKQEIISRILK---EEAEEEKRKK 378
              G+   R    +R ++   ++E ++R  ++   +L K  +  + LK   EEAEEE  + 
Sbjct: 1897 LSGKLVRR--AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRA 1954

Query: 379  Q 379
            Q
Sbjct: 1955 Q 1955


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2027

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2073

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2074 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2112

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 402  FCKKT 406
            F ++T
Sbjct: 2173 FAEQT 2177



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2253

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2254 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2311

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2432 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2609

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2668



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1550 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1607

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1608 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1660 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1712

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1713 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1714

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 377  KKQ 379
              Q
Sbjct: 1895 LAQ 1897



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1274

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1275 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1328

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1329 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1437

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1438 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1493

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1533



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 921  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 981  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1038

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1095

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1150

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1859 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1917

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2031

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2077

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2078 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2116

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176

Query: 402  FCKKT 406
            F ++T
Sbjct: 2177 FAEQT 2181



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2257

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2258 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2315

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2436 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2613

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2672



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1554 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1611

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1612 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1663

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1664 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1716

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1717 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1718

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898

Query: 377  KKQ 379
              Q
Sbjct: 1899 LAQ 1901



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1278

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1279 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1332

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1333 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1387

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1441

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1442 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1497

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1537



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 925  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 984

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 985  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1042

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1099

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1100 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1154

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1212


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1855 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2027

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2073

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2074 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2112

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172

Query: 402  FCKKT 406
            F ++T
Sbjct: 2173 FAEQT 2177



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2253

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2254 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2311

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2432 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2609

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2668



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1550 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1607

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1608 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1660 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1712

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1713 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1714

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 377  KKQ 379
              Q
Sbjct: 1895 LAQ 1897



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1274

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1275 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1328

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1329 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1437

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1438 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1493

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1533



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 921  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 981  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1038

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1095

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1150

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1823 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1881

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 1995

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2041

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2042 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2080

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140

Query: 402  FCKKT 406
            F ++T
Sbjct: 2141 FAEQT 2145



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2221

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2222 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2279

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2400 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2577

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2636



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1518 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1575

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1576 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1627

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1628 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1680

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1681 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1682

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862

Query: 377  KKQ 379
              Q
Sbjct: 1863 LAQ 1865



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1242

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1243 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1296

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1297 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1351

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1405

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1406 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1461

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1501



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 889  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 948

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 949  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1006

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1063

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1064 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1118

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1176


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1992 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 2050

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2164

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2210

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2211 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2249

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309

Query: 402  FCKKT 406
            F ++T
Sbjct: 2310 FAEQT 2314



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2390

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2391 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2448

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2569 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2746

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2805



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1687 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1744

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1745 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1796

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1797 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1849

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1850 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1851

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031

Query: 377  KKQ 379
              Q
Sbjct: 2032 LAQ 2034



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1367 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1411

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1412 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1465

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1466 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1520

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1574

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1575 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1630

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1670



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 1058 EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1117

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 1118 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1175

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1232

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1233 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1287

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1833 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1891

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2005

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2051

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2052 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2090

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150

Query: 402  FCKKT 406
            F ++T
Sbjct: 2151 FAEQT 2155



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2231

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2232 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2289

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2410 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2587

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2646



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1528 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1585

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1586 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1637

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1638 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1690

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1691 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1692

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872

Query: 377  KKQ 379
              Q
Sbjct: 1873 LAQ 1875



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1208 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1252

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1253 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1306

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1307 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1361

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1415

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1416 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1471

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1511



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 899  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 958

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 959  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1016

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1073

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1074 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1128

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1841 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1899

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2013

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2059

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2060 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2098

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158

Query: 402  FCKKT 406
            F ++T
Sbjct: 2159 FAEQT 2163



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2239

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2240 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2297

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2418 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2595

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2654



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1536 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1593

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1594 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1645

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1646 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1698

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1699 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1526 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1700

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880

Query: 377  KKQ 379
              Q
Sbjct: 1881 LAQ 1883



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1216 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1260

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1261 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1314

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1315 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1369

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1423

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1424 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1479

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1519



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 907  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 966

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 967  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1024

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1081

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1082 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1136

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1194


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 87/365 (23%), Positives = 154/365 (42%), Gaps = 52/365 (14%)

Query: 52   SVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDL 111
            ++KE + + ++L++   ++  Q   L +  +A  K   E+ L   +   +    RQ+  +
Sbjct: 1882 ALKEKEAENERLRRLAEDEAFQRRRLEEQ-AAQHKADIEERLAQLRKASDSELERQKGLV 1940

Query: 112  ID--KQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENT 169
             D  +Q+  V  EI   + +   AA G+ +            E  L+S+ +A L+ +   
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000

Query: 170  MWHIEIQEGRLEAFRTADR----EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR 225
                E +  R EA     +    EE  A  R+  +   E+L        KVE  R LR R
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL------KAKVEEARRLRER 2054

Query: 226  KSLNTQKELGLRH---QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
                + ++L L     QK L+   K H  AV            Q+K++E++  + +++  
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAV------------QQKEQELQ--QTLQQEQ 2100

Query: 283  DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQ 342
              +  L+G   A R          RA  E  E RVQAE++A  AQ R         R+ +
Sbjct: 2101 SVLDQLRGEAEAAR----------RAAEEAEEARVQAEREA--AQSR---------RQVE 2139

Query: 343  ELEAQKRAFEEEQKLRKQ-EIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISD 401
            E E  K++ EE+ + R Q +  +  L++EAE+E  ++     +A  +    D        
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199

Query: 402  FCKKT 406
            F ++T
Sbjct: 2200 FAEQT 2204



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/480 (22%), Positives = 205/480 (42%), Gaps = 51/480 (10%)

Query: 6    SLLPED--ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKL 63
            +LL E+   L A+A     +R ++E+  F ++  ++E          S +K      ++ 
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL---------SKLKARIEAENRA 2280

Query: 64   KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI 123
                 +D TQ F L++    + ++ EE    +   + E    RQ  +    QQ A+A ++
Sbjct: 2281 LILRDKDNTQRF-LQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKM 2338

Query: 124  ATE-----EEAGNMAAVGRLQAVSRRLFAELEN--ERDLQSRTEAVLKESENTMWHIEIQ 176
              E     +EA  + A   L    + L  E     + D +   + + +E++     +E +
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398

Query: 177  EGR-LEAFRTADREEVE-ATGRRLQVRA---AEQLCREQEALGKVERNRLLRIRKSLNTQ 231
              R LE    A+R ++  A   R Q RA   A++  ++ E +G+      L  ++ +   
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458

Query: 232  KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVV----A 287
            + L ++ Q+   DA +  + A+  L+    +++++ K  +++  E    + + ++    A
Sbjct: 2459 QTLEIQRQQSDHDAERLRE-AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517

Query: 288  LKGSISANRDTL---RKFQAWDRAKAELAEQRVQAEKKAI----------LAQGRDAFRH 334
            L+ S  + +D+L    +F   ++AK E   Q   A+ + +          + Q R     
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577

Query: 335  LVHQRRRQELEAQ---KRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTL 391
             + + RR++ EA+   +R  EE Q+L +Q      L  E E ++ ++Q      +HR  L
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQHRAAL 2636

Query: 392  RDKTWNYISDFCKKTTVPTNTYTLDYEAA-AGPGPS--RLLEVVSSELIQGDPGASSEEE 448
                    S      T+P     LD  AA A P  S   L   VS++ +Q + G  S EE
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEE 2695



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 101/411 (24%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 10   EDELLADALLLED-ERDELE-DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT 67
            E E+ A A   E  ER  L  + E  +  L  EA +    G    ++ L   A++ + + 
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQEL-FTEKMRGELRACRQRRDLIDKQQEA-VAAEIA- 124
             + + +A  LR+ +    +   + E+    +++ E  A R+++  +   +E  + AE A 
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576

Query: 125  -----TEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
                  E E      V  L+   R   AEL+++R   +   A L+ S     H+ + + R
Sbjct: 1577 RRLRQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEE-HVAVAQLR 1634

Query: 180  LEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIR---KSLNTQKELGL 236
             EA R A +++ EA       RA E+  RE E   +++ N  LR+R   + +  QK L  
Sbjct: 1635 EEAERRA-QQQAEAE------RAREEAERELERW-QLKANEALRLRLQAEEVAQQKSLAQ 1686

Query: 237  RH-QKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISAN 295
               +K  E+A +    A R  KA    +R++E  E+    E  ++R  A    +  ++A 
Sbjct: 1687 AEAEKQKEEAERE---ARRRGKAEEQAVRQRELAEQ----ELEKQRQLAEGTAQQRLAAE 1739

Query: 296  RDTLRKFQAWDRAKAELAEQRVQA--------------------EKKAILAQGRDAFRHL 335
            ++ +R      RA+ E  EQ+ Q                     E +A LA+ R     L
Sbjct: 1740 QELIRL-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794

Query: 336  VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEE-------AEEEKRKKQ 379
            +  + R E E++  + + +Q+L  +    R L EE       AEE KR++Q
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 69/363 (19%), Positives = 147/363 (40%), Gaps = 21/363 (5%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKT-AEDRTQAFHLRQNLSALDKMHEEQ 91
            +++   +EAE  +        +++    +  ++   AE +++     +  + L++  +E+
Sbjct: 1567 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626

Query: 92   ELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQA---VSRRLFAE 148
             +   ++R E     Q++   ++ +E    E+   +   N A   RLQA     ++  A+
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686

Query: 149  LENERDLQSRTEAVL---KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQ 205
             E E+  +          K  E  +   E+ E  LE      R+  E T ++ ++ A ++
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGTAQQ-RLAAEQE 1741

Query: 206  LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRF--LKASLGRI 263
            L R +    + E+ R L   +    Q+E     QK  E   +  KV      L AS  R 
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801

Query: 264  REQEK------KEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRV 317
             E+ +      K+ +E      R +    A   +++      R+    D A+     +RV
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861

Query: 318  QAEKKAILAQGRDAFRHLVHQRRRQELEAQK-RAFEEEQKLRKQEIISRILKEEAEEEKR 376
             AEK A + +            + +E E ++ R   E++  +++ +  +  + +A+ E+R
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921

Query: 377  KKQ 379
              Q
Sbjct: 1922 LAQ 1924



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 78/341 (22%), Positives = 145/341 (42%), Gaps = 67/341 (19%)

Query: 69   EDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEE 128
            +++ QA  L  + +  +++ +EQ L  E               I++  E V       ++
Sbjct: 1257 QEQIQAMPLADSQAVREQLRQEQALLEE---------------IERHGEKVEECQRFAKQ 1301

Query: 129  AGNMAAVGRLQAVSRRLFAELE------NERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
              N      LQ V+ +  A+LE       +  +QS +E+V++E  +   H       L  
Sbjct: 1302 YINAIKDYELQLVTYK--AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS----ELTT 1355

Query: 183  FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
              +   + +  T RR++    E+L  +Q A    ER RL  +  +L  Q++L   H +  
Sbjct: 1356 LTSQYIKFISETLRRMEEE--ERLAEQQRA---EERERLAEVEAALEKQRQLAEAHAQAK 1410

Query: 243  EDARKNHKVAVRFLKASLGRIRE------QEKKEEMECHEYMRRRMDAVVALKGSISANR 296
              A +  K   + ++  + R  E      Q+K+   E  + +R+  +A +  K       
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA------ 1464

Query: 297  DTLRKFQAWDRAKAELAEQ----RVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKR-AF 351
               R+ +A +R++  + E+    R+Q E       G +     + + R +E EAQKR A 
Sbjct: 1465 ---RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL-RARAEEAEAQKRQAQ 1520

Query: 352  EEEQKLRKQ-------------EIISRILKEEAEEEKRKKQ 379
            EE ++LR+Q             E+ SR+ K EAE  + K++
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQR 1560



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 35/298 (11%)

Query: 107  QRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVS---------RRLFAELENERDLQS 157
            ++R  +   +    A +   ++AG      RL A           ++L   LE     +S
Sbjct: 948  EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1007

Query: 158  RTEAVLKESENTMWHIEIQEGR-LEAFRTA-DREEVEATGRRLQVRAAEQLCREQEALGK 215
            R +  + E ++    +E  E R +   R   D+E      +R+  +   Q   E E LGK
Sbjct: 1008 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQA--EVEGLGK 1065

Query: 216  ------VERNRLLRIRK------SLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
                   E  ++L + +      +L ++ EL L     LE  R    + +  LK     I
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK---LEQVRSLSAIYLEKLKTISLVI 1122

Query: 264  REQEKKEE-MECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            R  +  EE +  HE   +   AV A    + A + +L+K     RA+AE A+Q      +
Sbjct: 1123 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL----RAQAE-AQQPTFDALR 1177

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKL-RKQEIISRILKEEAEEEKRKKQ 379
              L   ++    L  +   +++E ++      Q L R Q ++++    + E E+  +Q
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 93/406 (22%), Positives = 171/406 (42%), Gaps = 67/406 (16%)

Query: 10   EDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHS--SSVKELDTDADKLKKKT 67
            E + L+ A  LE+  +  E+ E   K L  E ED V        +V EL+     L+ + 
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRD--------LIDKQQEAV 119
             E +TQ   L   L A +      E+  + ++G+     Q RD         + +Q    
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 120  AAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
              E+  E +   +AA     A  ++L  +L   +DL+ + ++ +K  E  +  +   + +
Sbjct: 1602 ETELEDERKQRALAA-----AAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 180  LEAFR------TADREEVEATGRRLQVRAAE---QLCREQEALGKVERNRLLRIRKSLNT 230
            ++ F+       A R+E+ AT +  + +A      L + QE L   ER R          
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR---------- 1703

Query: 231  QKELGLRHQKLLEDARKNHKVAVRFLKASL-GRIREQEKKEEMECHEYMRRRMDAVVALK 289
             K+  L  ++L E+           L +SL GR   Q++K  +E    + +  + +   +
Sbjct: 1704 -KQADLEKEELAEE-----------LASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQ 1749

Query: 290  GSISANRDTLRK-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQK 348
            G++ A  D +RK  Q  ++   ELA +R  A+K     Q          +R+ +EL ++ 
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL--------ERQNKELRSKL 1801

Query: 349  RAFEEEQKLRKQEIISRI------LKEEAEEEKRKKQHPPTSARHR 388
               E   K + +  I+ +      L+E+ E+E R+KQ    S + +
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/415 (21%), Positives = 170/415 (40%), Gaps = 48/415 (11%)

Query: 54   KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGE----LRACRQRR 109
            +E+    D+L+K     +     L++      ++ EE+ L  E+++ E      A   R 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911

Query: 110  DLIDKQQE------AVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSR----- 158
             L  K+QE       + A +  EE+ G      R +   + L  E + E +  +R     
Sbjct: 912  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971

Query: 159  ----TEAVLKESENTMWHIEIQEGRLEAFRTADREEVE--ATGRRLQVRAAEQLCREQEA 212
                 EA +K+ E+ +  ++ Q  +L   R    E +    T    +   A+ L + +  
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031

Query: 213  LGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEM 272
               +     +R++K   +++EL    +KL  DA   H+  +  L+A +  ++ Q  K+E 
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEE 1090

Query: 273  ECHEYMRRRMDAVV----------ALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            E    + R  D +            L+G IS  ++ L   +A  R KAE  ++ +  E +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQKRDLGEELE 1149

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPP 382
            A+  +  D       Q   QEL A++   E+E  + K+ +       EA+ ++ +++H  
Sbjct: 1150 ALKTELEDTLDSTATQ---QELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKH-- 1201

Query: 383  TSARHRLTLRDKTWNYISDFCK-KTTVPTNTYTLDYEAAAGPGPSRLLEVVSSEL 436
              A   LT        +  F + K  +  N  TL+ E A   G  R+L     E+
Sbjct: 1202 AQAVEELT------EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 40/378 (10%)

Query: 20   LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRT----QAF 75
            LE  +  LE    ++K  L+E ED++     + ++ L+ +   LK +   D      Q  
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNE 1588

Query: 76   HLRQNLSALDKMHE-EQELFTEKMRGELRACRQRR---DLIDKQQEAVAAEIATEEEAGN 131
              R+ L    ++HE E EL  E+ +  L A  +++   DL D + +A +A I   EEA  
Sbjct: 1589 EKRRQLQR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGREEA-- 1643

Query: 132  MAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEV 191
            +  + +LQA  +    ELE+ R  +    A  KE+E     +E    +L+       E++
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ-------EDL 1696

Query: 192  EATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKV 251
             A       RA +Q   E+E L +   + L       + ++ L  R  +L E+  +    
Sbjct: 1697 AAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-- 1749

Query: 252  AVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAE 311
                ++A   R+R+  ++ E   +E    R  A         + R  L +     R+K  
Sbjct: 1750 --GNMEAMSDRVRKATQQAEQLSNELATERSTA-----QKNESARQQLERQNKELRSKLH 1802

Query: 312  LAEQRVQAEKKAILAQGRDAFRHL---VHQRRRQELEAQKRAFEEEQKLRKQEIISRILK 368
              E  V+++ K+ +A        L   V Q  R++  A K   ++++KL+  EI+ ++  
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVED 1860

Query: 369  EEAEEEKRKKQHPPTSAR 386
            E    E+ K+Q    +AR
Sbjct: 1861 ERKMAEQYKEQAEKGNAR 1878



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 82/383 (21%), Positives = 164/383 (42%), Gaps = 45/383 (11%)

Query: 14   LADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQ 73
            L D L     + EL         +L++A D+    H + V+E+     +  ++  E   Q
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 74   AFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
                + NL   DK  +  E     + GELR   Q +  ++ +++ + A++   +E  +  
Sbjct: 1215 FKRAKANL---DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKC 1268

Query: 134  AVGRLQAVSRRLFAELENE-RDLQSRTEAV---LKESENTMWHIEIQEGRLEAFRTADRE 189
            + G       R  AEL ++   LQ+  E+V   L E+E     +      L + +  D +
Sbjct: 1269 SDG------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQ 1321

Query: 190  EVEATGRRLQVRAAEQLCREQEALGKVERNRLL-RIRKSLNTQKELGLRHQKLLEDARKN 248
            E+     R ++  + +L + +E     ERN L  ++ + +  ++ L  RH   L     +
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSD 1375

Query: 249  HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRA 308
             K  ++   +++  + E +K+ + E  E + ++ +   A    +   ++ L+  Q  D  
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQ--QELDDL 1432

Query: 309  KAELAEQR---VQAEKK-----AILAQGRDAFRHLVHQRRRQELEAQK---------RAF 351
              +L  QR      EKK      +LA+ ++       +R R E EA++         RA 
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 352  EEEQKLRKQ-EIISRILKEEAEE 373
            EE  + +++ E  +++LK E E+
Sbjct: 1493 EEALEAKEELERTNKMLKAEMED 1515



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 32/142 (22%), Positives = 68/142 (47%), Gaps = 21/142 (14%)

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           LL+  R+  ++  +  +  L + +E+++K E E  E  ++           ++  ++ L+
Sbjct: 844 LLQVTRQEEEMQAK--EDELQKTKERQQKAENELKELEQKH--------SQLTEEKNLLQ 893

Query: 301 K-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQR--RRQELEAQKRAFEEEQKL 357
           +  QA     AE  E RV+      LA  +     ++H+   R +E E + +  + E+K 
Sbjct: 894 EQLQAETELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947

Query: 358 RKQEIISRILKEEAEEEKRKKQ 379
             Q+++   L+E+ EEE+  +Q
Sbjct: 948 MAQQMLD--LEEQLEEEEAARQ 967


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 93/406 (22%), Positives = 171/406 (42%), Gaps = 67/406 (16%)

Query: 10   EDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHS--SSVKELDTDADKLKKKT 67
            E + L+ A  LE+  +  E+ E   K L  E ED V        +V EL+     L+ + 
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRD--------LIDKQQEAV 119
             E +TQ   L   L A +      E+  + ++G+     Q RD         + +Q    
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 120  AAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
              E+  E +   +AA     A  ++L  +L   +DL+ + ++ +K  E  +  +   + +
Sbjct: 1609 ETELEDERKQRALAA-----AAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 180  LEAFR------TADREEVEATGRRLQVRAAE---QLCREQEALGKVERNRLLRIRKSLNT 230
            ++ F+       A R+E+ AT +  + +A      L + QE L   ER R          
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR---------- 1710

Query: 231  QKELGLRHQKLLEDARKNHKVAVRFLKASL-GRIREQEKKEEMECHEYMRRRMDAVVALK 289
             K+  L  ++L E+           L +SL GR   Q++K  +E    + +  + +   +
Sbjct: 1711 -KQADLEKEELAEE-----------LASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQ 1756

Query: 290  GSISANRDTLRK-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQK 348
            G++ A  D +RK  Q  ++   ELA +R  A+K     Q          +R+ +EL ++ 
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL--------ERQNKELRSKL 1808

Query: 349  RAFEEEQKLRKQEIISRI------LKEEAEEEKRKKQHPPTSARHR 388
               E   K + +  I+ +      L+E+ E+E R+KQ    S + +
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/415 (21%), Positives = 170/415 (40%), Gaps = 48/415 (11%)

Query: 54   KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGE----LRACRQRR 109
            +E+    D+L+K     +     L++      ++ EE+ L  E+++ E      A   R 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918

Query: 110  DLIDKQQE------AVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSR----- 158
             L  K+QE       + A +  EE+ G      R +   + L  E + E +  +R     
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 159  ----TEAVLKESENTMWHIEIQEGRLEAFRTADREEVE--ATGRRLQVRAAEQLCREQEA 212
                 EA +K+ E+ +  ++ Q  +L   R    E +    T    +   A+ L + +  
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038

Query: 213  LGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEM 272
               +     +R++K   +++EL    +KL  DA   H+  +  L+A +  ++ Q  K+E 
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEE 1097

Query: 273  ECHEYMRRRMDAVV----------ALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            E    + R  D +            L+G IS  ++ L   +A  R KAE  ++ +  E +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQKRDLGEELE 1156

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPP 382
            A+  +  D       Q   QEL A++   E+E  + K+ +       EA+ ++ +++H  
Sbjct: 1157 ALKTELEDTLDSTATQ---QELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKH-- 1208

Query: 383  TSARHRLTLRDKTWNYISDFCK-KTTVPTNTYTLDYEAAAGPGPSRLLEVVSSEL 436
              A   LT        +  F + K  +  N  TL+ E A   G  R+L     E+
Sbjct: 1209 AQAVEELT------EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 40/378 (10%)

Query: 20   LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRT----QAF 75
            LE  +  LE    ++K  L+E ED++     + ++ L+ +   LK +   D      Q  
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNE 1595

Query: 76   HLRQNLSALDKMHE-EQELFTEKMRGELRACRQRR---DLIDKQQEAVAAEIATEEEAGN 131
              R+ L    ++HE E EL  E+ +  L A  +++   DL D + +A +A I   EEA  
Sbjct: 1596 EKRRQLQR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGREEA-- 1650

Query: 132  MAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEV 191
            +  + +LQA  +    ELE+ R  +    A  KE+E     +E    +L+       E++
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ-------EDL 1703

Query: 192  EATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKV 251
             A       RA +Q   E+E L +   + L       + ++ L  R  +L E+  +    
Sbjct: 1704 AAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-- 1756

Query: 252  AVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAE 311
                ++A   R+R+  ++ E   +E    R  A         + R  L +     R+K  
Sbjct: 1757 --GNMEAMSDRVRKATQQAEQLSNELATERSTA-----QKNESARQQLERQNKELRSKLH 1809

Query: 312  LAEQRVQAEKKAILAQGRDAFRHL---VHQRRRQELEAQKRAFEEEQKLRKQEIISRILK 368
              E  V+++ K+ +A        L   V Q  R++  A K   ++++KL+  EI+ ++  
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVED 1867

Query: 369  EEAEEEKRKKQHPPTSAR 386
            E    E+ K+Q    +AR
Sbjct: 1868 ERKMAEQYKEQAEKGNAR 1885



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 82/383 (21%), Positives = 164/383 (42%), Gaps = 45/383 (11%)

Query: 14   LADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQ 73
            L D L     + EL         +L++A D+    H + V+E+     +  ++  E   Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 74   AFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
                + NL   DK  +  E     + GELR   Q +  ++ +++ + A++   +E  +  
Sbjct: 1222 FKRAKANL---DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKC 1275

Query: 134  AVGRLQAVSRRLFAELENE-RDLQSRTEAV---LKESENTMWHIEIQEGRLEAFRTADRE 189
            + G       R  AEL ++   LQ+  E+V   L E+E     +      L + +  D +
Sbjct: 1276 SDG------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQ 1328

Query: 190  EVEATGRRLQVRAAEQLCREQEALGKVERNRLL-RIRKSLNTQKELGLRHQKLLEDARKN 248
            E+     R ++  + +L + +E     ERN L  ++ + +  ++ L  RH   L     +
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSD 1382

Query: 249  HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRA 308
             K  ++   +++  + E +K+ + E  E + ++ +   A    +   ++ L+  Q  D  
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQ--QELDDL 1439

Query: 309  KAELAEQR---VQAEKK-----AILAQGRDAFRHLVHQRRRQELEAQK---------RAF 351
              +L  QR      EKK      +LA+ ++       +R R E EA++         RA 
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 352  EEEQKLRKQ-EIISRILKEEAEE 373
            EE  + +++ E  +++LK E E+
Sbjct: 1500 EEALEAKEELERTNKMLKAEMED 1522



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 32/142 (22%), Positives = 68/142 (47%), Gaps = 21/142 (14%)

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           LL+  R+  ++  +  +  L + +E+++K E E  E  ++           ++  ++ L+
Sbjct: 851 LLQVTRQEEEMQAK--EDELQKTKERQQKAENELKELEQKH--------SQLTEEKNLLQ 900

Query: 301 K-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQR--RRQELEAQKRAFEEEQKL 357
           +  QA     AE  E RV+      LA  +     ++H+   R +E E + +  + E+K 
Sbjct: 901 EQLQAETELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954

Query: 358 RKQEIISRILKEEAEEEKRKKQ 379
             Q+++   L+E+ EEE+  +Q
Sbjct: 955 MAQQMLD--LEEQLEEEEAARQ 974


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 93/406 (22%), Positives = 171/406 (42%), Gaps = 67/406 (16%)

Query: 10   EDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHS--SSVKELDTDADKLKKKT 67
            E + L+ A  LE+  +  E+ E   K L  E ED V        +V EL+     L+ + 
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRD--------LIDKQQEAV 119
             E +TQ   L   L A +      E+  + ++G+     Q RD         + +Q    
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608

Query: 120  AAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
              E+  E +   +AA     A  ++L  +L   +DL+ + ++ +K  E  +  +   + +
Sbjct: 1609 ETELEDERKQRALAA-----AAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 180  LEAFR------TADREEVEATGRRLQVRAAE---QLCREQEALGKVERNRLLRIRKSLNT 230
            ++ F+       A R+E+ AT +  + +A      L + QE L   ER R          
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR---------- 1710

Query: 231  QKELGLRHQKLLEDARKNHKVAVRFLKASL-GRIREQEKKEEMECHEYMRRRMDAVVALK 289
             K+  L  ++L E+           L +SL GR   Q++K  +E    + +  + +   +
Sbjct: 1711 -KQADLEKEELAEE-----------LASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQ 1756

Query: 290  GSISANRDTLRK-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQK 348
            G++ A  D +RK  Q  ++   ELA +R  A+K     Q          +R+ +EL ++ 
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL--------ERQNKELRSKL 1808

Query: 349  RAFEEEQKLRKQEIISRI------LKEEAEEEKRKKQHPPTSARHR 388
               E   K + +  I+ +      L+E+ E+E R+KQ    S + +
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/415 (21%), Positives = 170/415 (40%), Gaps = 48/415 (11%)

Query: 54   KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGE----LRACRQRR 109
            +E+    D+L+K     +     L++      ++ EE+ L  E+++ E      A   R 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918

Query: 110  DLIDKQQE------AVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSR----- 158
             L  K+QE       + A +  EE+ G      R +   + L  E + E +  +R     
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 159  ----TEAVLKESENTMWHIEIQEGRLEAFRTADREEVE--ATGRRLQVRAAEQLCREQEA 212
                 EA +K+ E+ +  ++ Q  +L   R    E +    T    +   A+ L + +  
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038

Query: 213  LGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEM 272
               +     +R++K   +++EL    +KL  DA   H+  +  L+A +  ++ Q  K+E 
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEE 1097

Query: 273  ECHEYMRRRMDAVV----------ALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            E    + R  D +            L+G IS  ++ L   +A  R KAE  ++ +  E +
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQKRDLGEELE 1156

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPP 382
            A+  +  D       Q   QEL A++   E+E  + K+ +       EA+ ++ +++H  
Sbjct: 1157 ALKTELEDTLDSTATQ---QELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKH-- 1208

Query: 383  TSARHRLTLRDKTWNYISDFCK-KTTVPTNTYTLDYEAAAGPGPSRLLEVVSSEL 436
              A   LT        +  F + K  +  N  TL+ E A   G  R+L     E+
Sbjct: 1209 AQAVEELT------EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 40/378 (10%)

Query: 20   LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRT----QAF 75
            LE  +  LE    ++K  L+E ED++     + ++ L+ +   LK +   D      Q  
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNE 1595

Query: 76   HLRQNLSALDKMHE-EQELFTEKMRGELRACRQRR---DLIDKQQEAVAAEIATEEEAGN 131
              R+ L    ++HE E EL  E+ +  L A  +++   DL D + +A +A I   EEA  
Sbjct: 1596 EKRRQLQR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGREEA-- 1650

Query: 132  MAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEV 191
            +  + +LQA  +    ELE+ R  +    A  KE+E     +E    +L+       E++
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ-------EDL 1703

Query: 192  EATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKV 251
             A       RA +Q   E+E L +   + L       + ++ L  R  +L E+  +    
Sbjct: 1704 AAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-- 1756

Query: 252  AVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAE 311
                ++A   R+R+  ++ E   +E    R  A         + R  L +     R+K  
Sbjct: 1757 --GNMEAMSDRVRKATQQAEQLSNELATERSTA-----QKNESARQQLERQNKELRSKLH 1809

Query: 312  LAEQRVQAEKKAILAQGRDAFRHL---VHQRRRQELEAQKRAFEEEQKLRKQEIISRILK 368
              E  V+++ K+ +A        L   V Q  R++  A K   ++++KL+  EI+ ++  
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVED 1867

Query: 369  EEAEEEKRKKQHPPTSAR 386
            E    E+ K+Q    +AR
Sbjct: 1868 ERKMAEQYKEQAEKGNAR 1885



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 82/383 (21%), Positives = 164/383 (42%), Gaps = 45/383 (11%)

Query: 14   LADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQ 73
            L D L     + EL         +L++A D+    H + V+E+     +  ++  E   Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 74   AFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
                + NL   DK  +  E     + GELR   Q +  ++ +++ + A++   +E  +  
Sbjct: 1222 FKRAKANL---DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKC 1275

Query: 134  AVGRLQAVSRRLFAELENE-RDLQSRTEAV---LKESENTMWHIEIQEGRLEAFRTADRE 189
            + G       R  AEL ++   LQ+  E+V   L E+E     +      L + +  D +
Sbjct: 1276 SDG------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQ 1328

Query: 190  EVEATGRRLQVRAAEQLCREQEALGKVERNRLL-RIRKSLNTQKELGLRHQKLLEDARKN 248
            E+     R ++  + +L + +E     ERN L  ++ + +  ++ L  RH   L     +
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSD 1382

Query: 249  HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRA 308
             K  ++   +++  + E +K+ + E  E + ++ +   A    +   ++ L+  Q  D  
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQ--QELDDL 1439

Query: 309  KAELAEQR---VQAEKK-----AILAQGRDAFRHLVHQRRRQELEAQK---------RAF 351
              +L  QR      EKK      +LA+ ++       +R R E EA++         RA 
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 352  EEEQKLRKQ-EIISRILKEEAEE 373
            EE  + +++ E  +++LK E E+
Sbjct: 1500 EEALEAKEELERTNKMLKAEMED 1522



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 32/142 (22%), Positives = 68/142 (47%), Gaps = 21/142 (14%)

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           LL+  R+  ++  +  +  L + +E+++K E E  E  ++           ++  ++ L+
Sbjct: 851 LLQVTRQEEEMQAK--EDELQKTKERQQKAENELKELEQKH--------SQLTEEKNLLQ 900

Query: 301 K-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQR--RRQELEAQKRAFEEEQKL 357
           +  QA     AE  E RV+      LA  +     ++H+   R +E E + +  + E+K 
Sbjct: 901 EQLQAETELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954

Query: 358 RKQEIISRILKEEAEEEKRKKQ 379
             Q+++   L+E+ EEE+  +Q
Sbjct: 955 MAQQMLD--LEEQLEEEEAARQ 974


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 93/406 (22%), Positives = 171/406 (42%), Gaps = 67/406 (16%)

Query: 10   EDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHS--SSVKELDTDADKLKKKT 67
            E + L+ A  LE+  +  E+ E   K L  E ED V        +V EL+     L+ + 
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541

Query: 68   AEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRD--------LIDKQQEAV 119
             E +TQ   L   L A +      E+  + ++G+     Q RD         + +Q    
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601

Query: 120  AAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGR 179
              E+  E +   +AA     A  ++L  +L   +DL+ + ++ +K  E  +  +   + +
Sbjct: 1602 ETELEDERKQRALAA-----AAKKKLEGDL---KDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 180  LEAFR------TADREEVEATGRRLQVRAAE---QLCREQEALGKVERNRLLRIRKSLNT 230
            ++ F+       A R+E+ AT +  + +A      L + QE L   ER R          
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR---------- 1703

Query: 231  QKELGLRHQKLLEDARKNHKVAVRFLKASL-GRIREQEKKEEMECHEYMRRRMDAVVALK 289
             K+  L  ++L E+           L +SL GR   Q++K  +E    + +  + +   +
Sbjct: 1704 -KQADLEKEELAEE-----------LASSLSGRNALQDEKRRLEAR--IAQLEEELEEEQ 1749

Query: 290  GSISANRDTLRK-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQK 348
            G++ A  D +RK  Q  ++   ELA +R  A+K     Q          +R+ +EL ++ 
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL--------ERQNKELRSKL 1801

Query: 349  RAFEEEQKLRKQEIISRI------LKEEAEEEKRKKQHPPTSARHR 388
               E   K + +  I+ +      L+E+ E+E R+KQ    S + +
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/415 (21%), Positives = 170/415 (40%), Gaps = 48/415 (11%)

Query: 54   KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGE----LRACRQRR 109
            +E+    D+L+K     +     L++      ++ EE+ L  E+++ E      A   R 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911

Query: 110  DLIDKQQE------AVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSR----- 158
             L  K+QE       + A +  EE+ G      R +   + L  E + E +  +R     
Sbjct: 912  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971

Query: 159  ----TEAVLKESENTMWHIEIQEGRLEAFRTADREEVE--ATGRRLQVRAAEQLCREQEA 212
                 EA +K+ E+ +  ++ Q  +L   R    E +    T    +   A+ L + +  
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031

Query: 213  LGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEM 272
               +     +R++K   +++EL    +KL  DA   H+  +  L+A +  ++ Q  K+E 
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQLAKKEE 1090

Query: 273  ECHEYMRRRMDAVV----------ALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            E    + R  D +            L+G IS  ++ L   +A  R KAE  ++ +  E +
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQKRDLGEELE 1149

Query: 323  AILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPP 382
            A+  +  D       Q   QEL A++   E+E  + K+ +       EA+ ++ +++H  
Sbjct: 1150 ALKTELEDTLDSTATQ---QELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKH-- 1201

Query: 383  TSARHRLTLRDKTWNYISDFCK-KTTVPTNTYTLDYEAAAGPGPSRLLEVVSSEL 436
              A   LT        +  F + K  +  N  TL+ E A   G  R+L     E+
Sbjct: 1202 AQAVEELT------EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 90/378 (23%), Positives = 163/378 (43%), Gaps = 40/378 (10%)

Query: 20   LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRT----QAF 75
            LE  +  LE    ++K  L+E ED++     + ++ L+ +   LK +   D      Q  
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNE 1588

Query: 76   HLRQNLSALDKMHE-EQELFTEKMRGELRACRQRR---DLIDKQQEAVAAEIATEEEAGN 131
              R+ L    ++HE E EL  E+ +  L A  +++   DL D + +A +A I   EEA  
Sbjct: 1589 EKRRQLQR--QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA-IKGREEA-- 1643

Query: 132  MAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEV 191
            +  + +LQA  +    ELE+ R  +    A  KE+E     +E    +L+       E++
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ-------EDL 1696

Query: 192  EATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKV 251
             A       RA +Q   E+E L +   + L       + ++ L  R  +L E+  +    
Sbjct: 1697 AAA-----ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-- 1749

Query: 252  AVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAE 311
                ++A   R+R+  ++ E   +E    R  A         + R  L +     R+K  
Sbjct: 1750 --GNMEAMSDRVRKATQQAEQLSNELATERSTA-----QKNESARQQLERQNKELRSKLH 1802

Query: 312  LAEQRVQAEKKAILAQGRDAFRHL---VHQRRRQELEAQKRAFEEEQKLRKQEIISRILK 368
              E  V+++ K+ +A        L   V Q  R++  A K   ++++KL+  EI+ ++  
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK--EILLQVED 1860

Query: 369  EEAEEEKRKKQHPPTSAR 386
            E    E+ K+Q    +AR
Sbjct: 1861 ERKMAEQYKEQAEKGNAR 1878



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 82/383 (21%), Positives = 164/383 (42%), Gaps = 45/383 (11%)

Query: 14   LADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQ 73
            L D L     + EL         +L++A D+    H + V+E+     +  ++  E   Q
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 74   AFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
                + NL   DK  +  E     + GELR   Q +  ++ +++ + A++   +E  +  
Sbjct: 1215 FKRAKANL---DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV---QELQSKC 1268

Query: 134  AVGRLQAVSRRLFAELENE-RDLQSRTEAV---LKESENTMWHIEIQEGRLEAFRTADRE 189
            + G       R  AEL ++   LQ+  E+V   L E+E     +      L + +  D +
Sbjct: 1269 SDG------ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS-QLQDTQ 1321

Query: 190  EVEATGRRLQVRAAEQLCREQEALGKVERNRLL-RIRKSLNTQKELGLRHQKLLEDARKN 248
            E+     R ++  + +L + +E     ERN L  ++ + +  ++ L  RH   L     +
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSD 1375

Query: 249  HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRA 308
             K  ++   +++  + E +K+ + E  E + ++ +   A    +   ++ L+  Q  D  
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEI-ENLTQQYEEKAAAYDKLEKTKNRLQ--QELDDL 1432

Query: 309  KAELAEQR---VQAEKK-----AILAQGRDAFRHLVHQRRRQELEAQK---------RAF 351
              +L  QR      EKK      +LA+ ++       +R R E EA++         RA 
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 352  EEEQKLRKQ-EIISRILKEEAEE 373
            EE  + +++ E  +++LK E E+
Sbjct: 1493 EEALEAKEELERTNKMLKAEMED 1515



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 32/142 (22%), Positives = 68/142 (47%), Gaps = 21/142 (14%)

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           LL+  R+  ++  +  +  L + +E+++K E E  E  ++           ++  ++ L+
Sbjct: 844 LLQVTRQEEEMQAK--EDELQKTKERQQKAENELKELEQKH--------SQLTEEKNLLQ 893

Query: 301 K-FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQR--RRQELEAQKRAFEEEQKL 357
           +  QA     AE  E RV+      LA  +     ++H+   R +E E + +  + E+K 
Sbjct: 894 EQLQAETELYAEAEEMRVR------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947

Query: 358 RKQEIISRILKEEAEEEKRKKQ 379
             Q+++   L+E+ EEE+  +Q
Sbjct: 948 MAQQMLD--LEEQLEEEEAARQ 967


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 94/405 (23%), Positives = 169/405 (41%), Gaps = 57/405 (14%)

Query: 16  DALLLEDERDELEDPEFDIK-CLLQEAEDDVDPGHSS---SVKELDTDADKLKKKTAEDR 71
           DAL LE  R+ + D E   K   LQE    V+   S    +VKEL    ++ K    + +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ 262

Query: 72  TQAF--HLRQNLSA----LDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAA---E 122
            QA   HL + L +    L    EE EL+        R  +Q+ + + +Q+E +     +
Sbjct: 263 LQAEADHLGKELQSVSAKLQAQVEENELWN-------RLNQQQEEKMWRQEEKIQEWEEK 315

Query: 123 IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
           I  +EE      +   +   R    ++  + ++    E  ++  E  MW  E +  RLE 
Sbjct: 316 IQEQEEK-----IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370

Query: 183 FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
                 E++         R  E+   EQE + + E  R          Q+E  +R Q+  
Sbjct: 371 MMWEKEEKI---------RELEEKMHEQEKIREQEEKR----------QEEEKIREQEKR 411

Query: 243 EDARKNHKVAVRFLKASLGRIREQEKK---EEMECHEYMRRRMDAVVALKGSISANRDTL 299
           ++           ++    +IREQEKK   +E + HE  + R +     +  +    + +
Sbjct: 412 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 471

Query: 300 RKFQAWDRAKAELAEQ---RVQAEK----KAILAQGRDAFRHLVHQRRRQE---LEAQKR 349
           R+ +   R K ++ EQ   R Q EK    +  +    +  R    +  RQE    E +++
Sbjct: 472 REQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK 531

Query: 350 AFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLRDK 394
             E+E+K+R+QE + +  +E+  E++ K Q      R    +R++
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 71/358 (19%), Positives = 161/358 (44%), Gaps = 33/358 (9%)

Query: 54  KELDTDADKLKKKTAEDRTQAFHLRQNLSAL----DKMHEEQELF---TEKMRGELRACR 106
           +++    +K++++  + R Q   +R+    +    +KM  ++E+     EKMR       
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373

Query: 107 QRRDLIDKQQEAVAAE--IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLK 164
           ++ + I + +E +  +  I  +EE        R Q   +   A++  + +     E  ++
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433

Query: 165 ESENTMWHIEIQEGRLEAFRTADR--EEVEATGRRLQVRAAEQLCREQEALGKVERNRLL 222
           E E  MW  E +    E  R  ++  E+ E   +  ++R  E++ R++E + + E+    
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK---- 489

Query: 223 RIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRM 282
            IRK    Q+E   R ++ + D  +  +     +     +IREQE+K   E  E +R + 
Sbjct: 490 -IRK----QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR-EQEEKIREQE 543

Query: 283 DAVVALKGSISANRDTLRKFQAWDRAKAELAEQ--RVQAEKKAILAQGRDAFRHLVHQRR 340
           + +   +  +    + +++ +   R + ++ EQ  +++ +K+ I  Q    +      R 
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603

Query: 341 RQEL---------EAQKRAFEEEQKLRKQEIISRILKEEA-EEEKRKKQHPPTSARHR 388
           ++E+         E +++  E+E+K+++QE   R  +E+  E+E R +Q       H+
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 99/422 (23%), Positives = 186/422 (44%), Gaps = 84/422 (19%)

Query: 9   PEDELLADALLLEDERDELEDPEFDIKCLL-QEAEDDVDPGHSS-SVKELDTDADKLKKK 66
           PEDE  A     E  R ELE     I+ L  Q+ E  +   +S  +VK+L+ +A  L  +
Sbjct: 107 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 166

Query: 67  TAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI--- 123
             +    A  L Q LSA+    ++ + + E++               K+++A++ E+   
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELT--------------KERDALSLELYRN 212

Query: 124 -ATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
             T+EE                       E++ + + +  L ESE +    EIQ    E 
Sbjct: 213 TITDEEL---------------------KEKNAKLQEKLQLVESEKS----EIQLNVKEL 247

Query: 183 FRTADREEVEATGRRLQVRAAEQLCREQEALG-----KVERNRLLRIRKSLNTQKELGL- 236
            R  +R ++    ++LQ  A + L +E +++      +VE N L      LN Q+E  + 
Sbjct: 248 KRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQAQVEENELWN---RLNQQQEEKMW 303

Query: 237 RHQKLLEDARKNHKVAVRFLKASLGRIREQEKK----EEM--ECHEYMRRRMDAVVALKG 290
           R ++ +++  +  +     ++    +IREQE+K    EEM  E  E MRR+ + +   + 
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363

Query: 291 SISANRDTLRKFQAWDRAKA--ELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEA-- 346
            +    + +     W++ +   EL E+  + EK     + R     +  Q +RQE EA  
Sbjct: 364 KMRRLEEMM-----WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 418

Query: 347 ---QKRAFEEEQKLRKQEIISRILKEEA---------EEEKRKKQHPPTSARHRLTLRDK 394
              +++  E+E+K+R+QE   ++ ++E          EEEKR++Q        ++  +++
Sbjct: 419 WRQEEKIREQEEKIREQE--KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 476

Query: 395 TW 396
            W
Sbjct: 477 IW 478


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 84/391 (21%), Positives = 169/391 (43%), Gaps = 45/391 (11%)

Query: 16  DALLLEDERDELEDPEFDIK-CLLQEAEDDVDPGHSS---SVKELDTDADKLKKKTAEDR 71
           DAL LE  R+ + D E   K   LQE    V+   S    +VKEL    ++ K    + +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ 262

Query: 72  TQAF--HLRQNLSA----LDKMHEEQELFT-------EKMRGELRACRQRRDLIDKQQEA 118
            QA   HL + L +    L    EE EL+        EKM  +    ++  + I +Q+E 
Sbjct: 263 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK 322

Query: 119 VAAE---IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEI 175
           +  +   I  +EE      + R + +      ++  + ++    E  ++  E  MW  E 
Sbjct: 323 IREQEEKIREQEEK-----MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 377

Query: 176 QEGRLEAFRTADREEVEATGRRL----QVRAAEQLCREQEALGKVERNRLLRIRKSLNTQ 231
           +  R E       E++     ++    ++R  E+  +E+E + + E+ R  +  K    +
Sbjct: 378 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK-RQEQEAKMWRQE 436

Query: 232 KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEME---CHEYMRRRMDAVVAL 288
           +++  + +K+ E  +K  +   +  +    +IRE+EK++E E     E      + +   
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQE--KIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494

Query: 289 KGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQK 348
           K  +    + +RK       K    E++++ +++ I  Q    +R      + +++  Q+
Sbjct: 495 KEKMHEQEEKIRK----QEEKVWRQEEKIREQEEKIREQEEKMWR------QEEKIREQE 544

Query: 349 RAFEEEQKLRKQEIISRILKEEAEEEKRKKQ 379
             + EE+K+ +QE I    K + +E+K  +Q
Sbjct: 545 EMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 76/396 (19%), Positives = 173/396 (43%), Gaps = 29/396 (7%)

Query: 7   LLPEDELLADALLLEDERDEL------EDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA 60
           LLP+ +L A+A  L  E   +      +  E ++   L + +++        ++E +   
Sbjct: 257 LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI 316

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAV- 119
            + ++K  E   +     + +   ++M  E+E   EKMR +     ++ + + +Q+E + 
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKE---EKMRRQEEMMWEKEEKMRRQEEMMW 373

Query: 120 --------AAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMW 171
                     E+  E+E        ++    +    E + + + + R +   +E E  MW
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433

Query: 172 HIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQ 231
               QE ++       RE+ +   R+ +    ++  RE+E   + E+  + R  + ++ Q
Sbjct: 434 R---QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIHEQ 488

Query: 232 KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGS 291
           +E+  + +K+ E   K  K   +  +    +IREQE+K   E  E M R+ + +   +  
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQE-EKIREQEEKIR-EQEEKMWRQEEKIREQEEM 546

Query: 292 ISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRH--LVHQRRRQELEAQKR 349
                    + + W+  K +  E ++  +++ I  Q    +R    + ++  +  E +++
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606

Query: 350 AFEEEQKLRKQE--IISRILKEEAEEEKRKKQHPPT 383
            +++E+K+R+QE  I  +  K   +EEK ++Q   T
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMT 642



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 80/404 (19%), Positives = 176/404 (43%), Gaps = 34/404 (8%)

Query: 9   PEDELLADALLLEDERDELEDPEFDIKCLL-QEAEDDVDPGHSS-SVKELDTDADKLKKK 66
           PEDE  A     E  R ELE     I+ L  Q+ E  +   +S  +VK+L+ +A  L  +
Sbjct: 107 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 166

Query: 67  TAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACR---QRRDLIDKQQEAVAAEI 123
             +    A  L Q LSA+    ++ + + E++  E  A      R  + D++ +   A++
Sbjct: 167 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 226

Query: 124 ATEEEAGNMAAVGRLQAVSRRLFAELEN------ERDLQSRTEAVLKESENTMWHIEIQE 177
             + +    +    +Q   + L  +LE       ++ LQ+  + + KE ++    ++ Q 
Sbjct: 227 QEKLQLVE-SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285

Query: 178 GRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLR 237
              E +   ++++ E   R+      E+  +E E   + +  ++    + +  Q+E   R
Sbjct: 286 EENELWNRLNQQQEEKMWRQ------EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339

Query: 238 HQKLLEDARKNHKVAVRFLKASLGRIREQE-----KKEEMECHEYMRRRMDAVVALKGSI 292
            ++++ +  +  +     +     ++R QE     K+E+M   E M    +  +      
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 399

Query: 293 SANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFE 352
              ++ +R+ +   + + ++ EQ  + E++A + +  +  R    + R QE    K+ + 
Sbjct: 400 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE----KKMWR 455

Query: 353 EEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTW 396
           +E+K+ +QE I        EEEKR++Q        ++  +++ W
Sbjct: 456 QEEKIHEQEKIR-------EEEKRQEQEEMWRQEEKIHEQEEIW 492



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 65/322 (20%), Positives = 148/322 (45%), Gaps = 29/322 (9%)

Query: 64  KKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAE- 122
           +K+  E++ +    RQ   A  KM  ++E    K+R +    R++   + +Q+E +  + 
Sbjct: 411 EKRQEEEKIREQEKRQEQEA--KMWRQEE----KIREQEEKIREQEKKMWRQEEKIHEQE 464

Query: 123 -IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLE 181
            I  EE+      + R +        E+  +++     E  +++ E  +W    QE ++ 
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHEQ-EEIWRQKEKMHEQEEKIRKQEEKVWR---QEEKIR 520

Query: 182 AFRTADREEVEATGRRLQ-VRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK 240
                 RE+ E   R+ + +R  E++ RE+E +   E+ ++    K    + ++  + +K
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH--EQEKIWEEEKRQEQEDKMWRQEEK 578

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           + E   K  +   +        IREQE+K + E  E M ++ + +   +  I    + +R
Sbjct: 579 IREQEEKVWRQEEK--------IREQEEKRQ-EQEEKMWKQEEKIREQEEKIQEQEEKIR 629

Query: 301 KFQAWDRAKAELAEQRVQ--AEKKAILAQGRDAFRHLVHQRRRQE---LEAQKRAFEEEQ 355
           + +   R + E+ +++ +   E++  + +  +  +       RQE    E +K+  E+E+
Sbjct: 630 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE 689

Query: 356 KLRKQEIISRILKEEAEEEKRK 377
           K+R+QE + +  +E+  E++ K
Sbjct: 690 KIREQEEMMQEQEEKMWEQEEK 711



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 67/379 (17%), Positives = 163/379 (43%), Gaps = 30/379 (7%)

Query: 21  EDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQN 80
           E++  ELE+   + + + ++ E   +       ++      K+ ++  + R Q   +R+ 
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449

Query: 81  LSAL----DKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAA-- 134
              +    +K+HE++++  E+ R E     ++ + I +Q+E    +    E+   +    
Sbjct: 450 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE 509

Query: 135 --VGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVE 192
             V R +   R    ++  + +   R E  ++E E      E    + + +    R+E E
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQE 569

Query: 193 ATGRRLQVRAAEQ---LCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNH 249
               R + +  EQ   + R++E + + E  R  +  K    ++++  + +K+ E   K  
Sbjct: 570 DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK-- 627

Query: 250 KVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAK 309
                 ++    +IREQE+  + E  E M  + + +   +  +    +T+ +       K
Sbjct: 628 ------IREQEEKIREQEEMTQ-EQEEKMGEQEEKMCEQEEKMQEQEETMWR----QEEK 676

Query: 310 AELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKE 369
               E++++ +++ I  Q       ++ ++  +  E +++  E+E+K+++QE   R  +E
Sbjct: 677 IREQEKKIREQEEKIREQ-----EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731

Query: 370 EA-EEEKRKKQHPPTSARH 387
           +  E+E R +Q       H
Sbjct: 732 KMWEQEVRLRQQEEKMQEH 750


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 91/381 (23%), Positives = 163/381 (42%), Gaps = 72/381 (18%)

Query: 56  LDTDADKLKKK---TAEDRTQAFHLRQNL-------SALDKMHEEQELFTEKMRGEL-RA 104
           L+ +  +L+KK   T ED+ +    R NL       + L++  +EQE   +  R E  R 
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERK 394

Query: 105 CRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTE---- 160
            R+R++   K+Q  +  ++  + E        R + + RR  A+ E ER  Q   E    
Sbjct: 395 ERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRR 454

Query: 161 --------------AVLKESENTMWHIEIQ---------EGRLEAFR---TADREEVEAT 194
                          VLK  + T+   E++         EG+L+  R   T  R+E+E+T
Sbjct: 455 QELLNQRNKEQEDIVVLKAKKKTL-EFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513

Query: 195 GRRLQVRAAE------QLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKN 248
            +  ++R AE      QL   Q+ LG     RL+  ++ LN Q +  ++   L  D+   
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLG-----RLIPEKQILNDQLK-QVQQNSLHRDSLVT 567

Query: 249 HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK--FQAWD 306
            K A+   + +   +R+Q  + E E     R ++  +      +   R+   K   Q   
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKE----TRSKLQEIDIFNNQLKELREIHNKQQLQKQK 623

Query: 307 RAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELE--------AQKRAFEEEQKLR 358
             +AE  +Q+ Q  K   L + ++  +    +R +Q LE         + R   EE+KL+
Sbjct: 624 SMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLK 683

Query: 359 KQEIISRILKEEAEEEKRKKQ 379
           ++E +    K++  EEK K++
Sbjct: 684 REESV----KKKDGEEKGKQE 700



 Score = 36.6 bits (83), Expect = 0.089
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 9/83 (10%)

Query: 307 RAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRI 366
           R +A L +QR + E+ A L +     +    +R RQE E +KR  E E++L KQ    R 
Sbjct: 368 RRQALLEQQRKEQERLAQLERAEQERK----ERERQEQE-RKRQLELEKQLEKQ----RE 418

Query: 367 LKEEAEEEKRKKQHPPTSARHRL 389
           L+ + EEE+RK+     +A+  L
Sbjct: 419 LERQREEERRKEIERREAAKREL 441



 Score = 33.5 bits (75), Expect = 0.76
 Identities = 41/188 (21%), Positives = 74/188 (39%), Gaps = 35/188 (18%)

Query: 5   GSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAE----------DDVDPGHSSSVK 54
           G L+PE ++L D L    +     D    +K  L+  E          D+V+    S ++
Sbjct: 539 GRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQ 598

Query: 55  ELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDK 114
           E+D   ++LK+                  L ++H +Q+L  +K         +   L  K
Sbjct: 599 EIDIFNNQLKE------------------LREIHNKQQLQKQK-------SMEAERLKQK 633

Query: 115 QQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIE 174
           +QE    E+  ++E     A  R +     +  E E++R  +   E  LK  E+      
Sbjct: 634 EQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693

Query: 175 IQEGRLEA 182
            ++G+ EA
Sbjct: 694 EEKGKQEA 701



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 38/184 (20%), Positives = 79/184 (42%), Gaps = 24/184 (13%)

Query: 20  LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQ 79
           L D++ +LE    DI+C L     +++  + S  +EL         + AE       L++
Sbjct: 485 LNDKKHQLEGKLQDIRCRLTTQRQEIESTNKS--REL---------RIAEITHLQQQLQE 533

Query: 80  NLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAV---- 135
           +   L ++  E+++  ++++   +    R  L+  ++   A E+A +     +  V    
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593

Query: 136 -GRLQAV-----SRRLFAELENERDLQ---SRTEAVLKESENTMWHIEIQEGRLEAFRTA 186
             +LQ +       +   E+ N++ LQ   S     LK+ E     IE+++ + EA R A
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 187 DREE 190
              +
Sbjct: 654 QERD 657


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 91/381 (23%), Positives = 163/381 (42%), Gaps = 72/381 (18%)

Query: 56  LDTDADKLKKK---TAEDRTQAFHLRQNL-------SALDKMHEEQELFTEKMRGEL-RA 104
           L+ +  +L+KK   T ED+ +    R NL       + L++  +EQE   +  R E  R 
Sbjct: 335 LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERK 394

Query: 105 CRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTE---- 160
            R+R++   K+Q  +  ++  + E        R + + RR  A+ E ER  Q   E    
Sbjct: 395 ERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRR 454

Query: 161 --------------AVLKESENTMWHIEIQ---------EGRLEAFR---TADREEVEAT 194
                          VLK  + T+   E++         EG+L+  R   T  R+E+E+T
Sbjct: 455 QELLNQRNKEQEDIVVLKAKKKTL-EFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513

Query: 195 GRRLQVRAAE------QLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKN 248
            +  ++R AE      QL   Q+ LG     RL+  ++ LN Q +  ++   L  D+   
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLG-----RLIPEKQILNDQLK-QVQQNSLHRDSLVT 567

Query: 249 HKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK--FQAWD 306
            K A+   + +   +R+Q  + E E     R ++  +      +   R+   K   Q   
Sbjct: 568 LKRALEAKELARQHLRDQLDEVEKE----TRSKLQEIDIFNNQLKELREIHNKQQLQKQK 623

Query: 307 RAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELE--------AQKRAFEEEQKLR 358
             +AE  +Q+ Q  K   L + ++  +    +R +Q LE         + R   EE+KL+
Sbjct: 624 SMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLK 683

Query: 359 KQEIISRILKEEAEEEKRKKQ 379
           ++E +    K++  EEK K++
Sbjct: 684 REESV----KKKDGEEKGKQE 700



 Score = 36.6 bits (83), Expect = 0.089
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 9/83 (10%)

Query: 307 RAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRI 366
           R +A L +QR + E+ A L +     +    +R RQE E +KR  E E++L KQ    R 
Sbjct: 368 RRQALLEQQRKEQERLAQLERAEQERK----ERERQEQE-RKRQLELEKQLEKQ----RE 418

Query: 367 LKEEAEEEKRKKQHPPTSARHRL 389
           L+ + EEE+RK+     +A+  L
Sbjct: 419 LERQREEERRKEIERREAAKREL 441



 Score = 33.5 bits (75), Expect = 0.76
 Identities = 41/188 (21%), Positives = 74/188 (39%), Gaps = 35/188 (18%)

Query: 5   GSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAE----------DDVDPGHSSSVK 54
           G L+PE ++L D L    +     D    +K  L+  E          D+V+    S ++
Sbjct: 539 GRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQ 598

Query: 55  ELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDK 114
           E+D   ++LK+                  L ++H +Q+L  +K         +   L  K
Sbjct: 599 EIDIFNNQLKE------------------LREIHNKQQLQKQK-------SMEAERLKQK 633

Query: 115 QQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIE 174
           +QE    E+  ++E     A  R +     +  E E++R  +   E  LK  E+      
Sbjct: 634 EQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693

Query: 175 IQEGRLEA 182
            ++G+ EA
Sbjct: 694 EEKGKQEA 701



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 38/184 (20%), Positives = 79/184 (42%), Gaps = 24/184 (13%)

Query: 20  LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQ 79
           L D++ +LE    DI+C L     +++  + S  +EL         + AE       L++
Sbjct: 485 LNDKKHQLEGKLQDIRCRLTTQRQEIESTNKS--REL---------RIAEITHLQQQLQE 533

Query: 80  NLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAV---- 135
           +   L ++  E+++  ++++   +    R  L+  ++   A E+A +     +  V    
Sbjct: 534 SQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKET 593

Query: 136 -GRLQAV-----SRRLFAELENERDLQ---SRTEAVLKESENTMWHIEIQEGRLEAFRTA 186
             +LQ +       +   E+ N++ LQ   S     LK+ E     IE+++ + EA R A
Sbjct: 594 RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653

Query: 187 DREE 190
              +
Sbjct: 654 QERD 657


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 88/357 (24%), Positives = 155/357 (43%), Gaps = 44/357 (12%)

Query: 25   DELEDPEFDIKCLLQEAEDD--VDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLS 82
            ++LE  EF+I  L+ + ED+  V+      +KEL    ++L ++   +R       +  S
Sbjct: 1081 EKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRS 1140

Query: 83   ALDKMHEEQELFTEKMRG------ELRACRQ------RRDLIDK--QQEAVAAEIATEEE 128
             L +  EE     E+  G      EL   R+      RRDL +   Q EA+ A +  ++ 
Sbjct: 1141 DLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR-KKH 1199

Query: 129  AGNMAAVGRLQAVSRRLFAELENER--------DLQSRTEAVLKESENTMWHIEIQEGRL 180
            A +MA +G      +R+  +LE E+        DL S  EA+ K   N        E ++
Sbjct: 1200 ADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQV 1259

Query: 181  EAFRTADREE------VEATGRRLQVRAAE---QLCREQEALGKVERNRLLRIRKSLNTQ 231
               +T + E+      + A   RLQ  A E   QL  +   + ++ R+      K  +TQ
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRS------KQASTQ 1313

Query: 232  KELGLRHQKLLEDARKNHKV-AVRFLKASLGRIREQEKKEEMECHEYMRR--RMDAVVAL 288
            +   L+HQ   E   KN    A++  +     +REQ ++E+    E  R   + ++ VA 
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA- 1372

Query: 289  KGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELE 345
            +       D +++ +  + AK +LA++  +AE+       + A      QR + E+E
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 79/357 (22%), Positives = 146/357 (40%), Gaps = 39/357 (10%)

Query: 49   HSSSVKELDTDADK---LKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRAC 105
            H  ++ +L  + DK   L K   +   Q   L  +L    K+  + E    K+ G+L+  
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1065

Query: 106  RQRRDLIDKQQEAVAAEIATEE-EAGNMAA-VGRLQAVSRRLFAELENERDLQSRTEAVL 163
            ++    ++  ++ +  ++  +E E  N+ + +   QAV  +L  ++   ++LQ+R E + 
Sbjct: 1066 QESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKI---KELQARIEELG 1122

Query: 164  KESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLR 223
            +E E           + E  R+    E+E    RL+   A      Q  L K       +
Sbjct: 1123 EEIEAE----RASRAKAEKQRSDLSRELEEISERLE--EAGGATSAQVELNKKREAEFQK 1176

Query: 224  IRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMD 283
            +R+ L   +E  L+H+ ++   RK H  ++  L   +  ++  ++K E E  E      D
Sbjct: 1177 LRRDL---EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDD 1233

Query: 284  AVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQE 343
                    +S+N + + K +          E +V +E K    + +     L  QR R +
Sbjct: 1234 --------LSSNAEAISKAKGNLEKMCRSLEDQV-SELKTKEEEQQRLINDLTAQRARLQ 1284

Query: 344  LEA--------QKRAFEEEQKLRKQEIISRI--LKEEAEEEKRKKQ---HPPTSARH 387
             EA        +K A   +    KQ    +I  LK + EEE + K    H   S+RH
Sbjct: 1285 TEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRH 1341



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 87/383 (22%), Positives = 160/383 (41%), Gaps = 64/383 (16%)

Query: 26   ELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDT-------------DADKLKKKTAEDRT 72
            EL   + ++   + E ++++D    +  + ++T             DA ++KKK   D  
Sbjct: 1567 ELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLN 1626

Query: 73   QAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNM 132
            +   +   L+  +++  E        +G L+  +   D   + QE +  ++A  E   N+
Sbjct: 1627 E---MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL 1683

Query: 133  AAVGRLQAVSRRLFAELEN-ERDLQSRTEAVLKESE-------------NTMWHIEIQEG 178
                 LQA    L+A LE  ER  +   + +L  SE             NT   +E    
Sbjct: 1684 -----LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738

Query: 179  RLEAFRTADREEVEATGRRLQVRA----------AEQLCREQEALGKVERNRLLRIRKSL 228
            +L++    + EEV    R  + +A          AE+L +EQ+    +E     R++K+L
Sbjct: 1739 QLQS----EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE-----RMKKNL 1789

Query: 229  -NTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIR---EQEKKEEMECHEYMRRRMDA 284
              T K+L  R  +  + A K  K  ++ L+A +  +    E E+K   E  + +R+    
Sbjct: 1790 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERR 1849

Query: 285  VVALKGSISANR-DTLRKFQAWDRAKAELAEQRVQAEKKAILAQGR-DAFRHLVHQRRRQ 342
            V  L      +R + LR     D+ +A++   + QAE+    +      FR L H+    
Sbjct: 1850 VKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELE-- 1907

Query: 343  ELEAQKRAFEEEQKLRKQEIISR 365
              EA++RA   E ++ K  + SR
Sbjct: 1908 --EAEERADIAESQVNKLRVKSR 1928


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 76/382 (19%), Positives = 171/382 (44%), Gaps = 33/382 (8%)

Query: 7   LLPEDELLADALLLEDERDEL------EDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDA 60
           LLP+ +L A+A  L  E   +      +  E ++   L + +++        ++E +   
Sbjct: 318 LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI 377

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA 120
            + ++K  E   +     + +   ++M  E+E   EKMR +     ++ + + +Q+E + 
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKE---EKMRRQEEMMWEKEEKMRRQEEMMW 434

Query: 121 AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL 180
            +   EE+   +      Q   R    E + + + + R +   +E E  MW    QE ++
Sbjct: 435 EK---EEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWR---QEEKI 486

Query: 181 EAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQK 240
                  RE+ E   R+ +    ++  RE+E   + E+  + R  + +  Q+E+  + +K
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIREQEEIWRQKEK 544

Query: 241 LLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLR 300
           + E   K  K   +         R++EK  + E  E +R + + V   +  I    + +R
Sbjct: 545 IHEQEEKIRKQEEKMW-------RQEEKMHDQE--EKIREQEEKVWRQEEKIREQEEKIR 595

Query: 301 KFQAWDRAKAELAEQRVQ--AEKKAILAQGRDAFRHLVHQRRRQE---LEAQKRAFEEEQ 355
           + +   R + E+ +++ +   E++  + +  +  +    + RRQE    E +K+  E+E+
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655

Query: 356 KLRKQEIISRILKEEAEEEKRK 377
           K+R+QE + +  +E+  E++ K
Sbjct: 656 KIREQEEMMQEQEEKMWEQEEK 677



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 68/353 (19%), Positives = 160/353 (45%), Gaps = 28/353 (7%)

Query: 54  KELDTDADKLKKKTAEDRTQAFHLRQNLSAL----DKMHEEQELF---TEKMRGELRACR 106
           +++    +K++++  + R Q   +R+    +    +KM  ++E+     EKMR +     
Sbjct: 375 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 434

Query: 107 QRRDLIDKQQEAVAAE--IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLK 164
           ++ + I + +E +  +  I  +EE        R Q   +   A++  + +     E  ++
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 494

Query: 165 ESENTMWHIEIQEGRLEAFRTADR--EEVEATGRRLQVRAAEQLCREQEALGKVERNRLL 222
           E E  MW  E +    E  R  ++  E+ E   +  ++R  E++ R++E + + E     
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554

Query: 223 RIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKK----EEM--ECHE 276
           +  K    ++++  + +K+ E   K  +   + ++    +IREQE+K    EEM  E  E
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEK-IREQEEKIREQEEKIREQEEMTQEQEE 613

Query: 277 YMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLV 336
            M  + + +   +  +    + +R+       K    E++++ +++ I  Q       ++
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRR----QEEKIREQEKKIREQEEKIREQ-----EEMM 664

Query: 337 HQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEA-EEEKRKKQHPPTSARHR 388
            ++  +  E +++  E+E+K+++QE   R  +E+  E+E R +Q       H+
Sbjct: 665 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 99/422 (23%), Positives = 186/422 (44%), Gaps = 84/422 (19%)

Query: 9   PEDELLADALLLEDERDELEDPEFDIKCLL-QEAEDDVDPGHSS-SVKELDTDADKLKKK 66
           PEDE  A     E  R ELE     I+ L  Q+ E  +   +S  +VK+L+ +A  L  +
Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227

Query: 67  TAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI--- 123
             +    A  L Q LSA+    ++ + + E++               K+++A++ E+   
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELT--------------KERDALSLELYRN 273

Query: 124 -ATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
             T+EE                       E++ + + +  L ESE +    EIQ    E 
Sbjct: 274 TITDEEL---------------------KEKNAKLQEKLQLVESEKS----EIQLNVKEL 308

Query: 183 FRTADREEVEATGRRLQVRAAEQLCREQEALG-----KVERNRLLRIRKSLNTQKELGL- 236
            R  +R ++    ++LQ  A + L +E +++      +VE N L      LN Q+E  + 
Sbjct: 309 KRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQAQVEENELWN---RLNQQQEEKMW 364

Query: 237 RHQKLLEDARKNHKVAVRFLKASLGRIREQEKK----EEM--ECHEYMRRRMDAVVALKG 290
           R ++ +++  +  +     ++    +IREQE+K    EEM  E  E MRR+ + +   + 
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424

Query: 291 SISANRDTLRKFQAWDRAKA--ELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEA-- 346
            +    + +     W++ +   EL E+  + EK     + R     +  Q +RQE EA  
Sbjct: 425 KMRRQEEMM-----WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 479

Query: 347 ---QKRAFEEEQKLRKQEIISRILKEEA---------EEEKRKKQHPPTSARHRLTLRDK 394
              +++  E+E+K+R+QE   ++ ++E          EEEKR++Q        ++  +++
Sbjct: 480 WRQEEKIREQEEKIREQE--EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 537

Query: 395 TW 396
            W
Sbjct: 538 IW 539



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 83/380 (21%), Positives = 158/380 (41%), Gaps = 50/380 (13%)

Query: 16  DALLLEDERDELEDPEFDIK-CLLQEAEDDVDPGHSS---SVKELDTDADKLKKKTAEDR 71
           DAL LE  R+ + D E   K   LQE    V+   S    +VKEL    ++ K    + +
Sbjct: 264 DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ 323

Query: 72  TQAF--HLRQNLSA----LDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAA---E 122
            QA   HL + L +    L    EE EL+        R  +Q+ + + +Q+E +     +
Sbjct: 324 LQAEADHLGKELQSVSAKLQAQVEENELWN-------RLNQQQEEKMWRQEEKIQEWEEK 376

Query: 123 IATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
           I  +EE      +   +   R    ++  + ++    E  ++  E  MW  E +  R E 
Sbjct: 377 IQEQEEK-----IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 431

Query: 183 FRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
                 E++         R  E+   EQE + + E  R          Q+E  +R Q+  
Sbjct: 432 MMWEKEEKI---------RELEEKMHEQEKIREQEEKR----------QEEEKIREQEKR 472

Query: 243 EDARKNHKVAVRFLKASLGRIREQEKK---EEMECHEYMRRRMDAVVALKGSISANRDTL 299
           ++           ++    +IREQE+K   +E + HE  + R +     +  +    + +
Sbjct: 473 QEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 532

Query: 300 RKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRK 359
           R+ +   R K ++ EQ  +  K+      ++     +H +  +  E +++ + +E+K+R+
Sbjct: 533 REQEEIWRQKEKIHEQEEKIRKQEEKMWRQE---EKMHDQEEKIREQEEKVWRQEEKIRE 589

Query: 360 QEIISRILKEEAEEEKRKKQ 379
           QE   R  +E+  E++   Q
Sbjct: 590 QEEKIREQEEKIREQEEMTQ 609


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 92/396 (23%), Positives = 170/396 (42%), Gaps = 51/396 (12%)

Query: 19  LLEDERDELEDPEFDIKCLLQEAEDD--VDPGHSSSVKELDTDADKLKKKTAEDRTQAFH 76
           LL++E+ EL     D++  +Q+AE++  +        ++L  +  KLK ++ +D      
Sbjct: 59  LLQNEQFEL-----DMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQ 113

Query: 77  LRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATE--EEAGNM-- 132
           +R+N   L ++  E++L    M  E  A    +D I  +Q    AEIA    EE   +  
Sbjct: 114 VRENSIELREL--EKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIK 171

Query: 133 ---AAVGRLQAVSRRLFAELEN-----ERDLQSRTEAVLKES------------------ 166
              AA  +      + + +LE      E+  Q   E +LKE                   
Sbjct: 172 EENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEK 231

Query: 167 ------ENTMW-HIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERN 219
                  N M  +IE  +     +R   REE+E   R++   A  Q  RE++ + KV+ N
Sbjct: 232 QQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQEN 291

Query: 220 --RLLRIRKSLNTQKELGLRHQKLLEDARKN--HKVAVRFLKASLGRIREQEKKEEMECH 275
             + L+++ +L  + E  LR ++ LE  R+    +      K+ L    E++ +++ E  
Sbjct: 292 EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351

Query: 276 EYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHL 335
           +    +M     +  +     +  RK      A+ +  E     +++    + R A   L
Sbjct: 352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKL 411

Query: 336 VHQRRRQELEAQKRAFEEEQ-KLRKQEIISRILKEE 370
           + +RR+Q L  ++R  EE Q + R+Q  I+ I++EE
Sbjct: 412 IEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEE 447



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 47/237 (19%), Positives = 108/237 (45%), Gaps = 29/237 (12%)

Query: 150 ENER--DLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQV------R 201
           EN+R  +LQ + E  L      + H  +++ ++      +  E+    ++L+       R
Sbjct: 78  ENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKER 137

Query: 202 AAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLG 261
           AA+    E++A+   +  R   I K++  + +  ++ +   ED  K +K   ++      
Sbjct: 138 AAQ--IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAED--KRNKAKAQYYLDLEK 193

Query: 262 RIREQEKKEEMECHEYMRRRM--DAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQA 319
           ++ EQEKK++    + ++ ++  D +V             RK    D+ + +   +++ A
Sbjct: 194 QLEEQEKKKQEAYEQLLKEKLMIDEIV-------------RKIYEEDQLEKQQKLEKMNA 240

Query: 320 EKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKR 376
            ++ I    ++  + L  +++R+E+E + R   E   +++Q    R+ K +  EEKR
Sbjct: 241 MRRYIEEFQKE--QALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKR 295


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 68/342 (19%), Positives = 157/342 (45%), Gaps = 26/342 (7%)

Query: 54  KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLID 113
           +EL     +L++K     ++   ++ N+  L +  E  +L   + + ++ A     D + 
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEA-----DRLG 268

Query: 114 KQQEAVAAEIATEEEAGNMAAVGRLQAVSR--RLFAELENERDLQSRTEAVLKESENTMW 171
           K+ ++V+A++  + E   +  +   Q   +  R   +++ + +     E  ++E E  MW
Sbjct: 269 KELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMW 328

Query: 172 HIEIQEGRLEAFRTADREEVEATGRRLQ-VRAAEQLCREQEA-LGKVERNRLLRIRKSLN 229
               QE ++       RE+ +   R+ + +R  E+  REQE  + + E     +  K   
Sbjct: 329 R---QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQE 385

Query: 230 TQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALK 289
            ++E+  + +K+ E   K  +   R  K    ++REQ++K   E  E M R+ + +  L+
Sbjct: 386 QEEEMWRQEEKIREQEEKRQEKMWRQEK----KMREQDEKIR-EQEEEMWRQEEKIRELE 440

Query: 290 GSISANRDTLRKFQAW---DRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEA 346
             +    + LR+ +     +  K +  E+++Q +++ I  Q    +R      + + L+ 
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR------QEKLLKQ 494

Query: 347 QKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHR 388
           +++ +E+E+K+ +QE      +E+ +E++ K Q      R +
Sbjct: 495 EEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQ 536



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 75/370 (20%), Positives = 162/370 (43%), Gaps = 44/370 (11%)

Query: 12  ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDR 71
           EL     L+E E+ E++    D+K  L+ A+  +        ++L  +AD+L K+     
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQ------QQLQVEADRLGKEL---- 271

Query: 72  TQAFHLRQNLSA-LDKMHEEQELFTE-KMRGELRACRQRRDLIDKQQEAVAAEIATEEEA 129
                  Q++SA L    EE EL+     + E +  RQ   + +++++    E+   E+ 
Sbjct: 272 -------QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324

Query: 130 GNMAAVGRLQAVSRRLFAELENERDLQSRT----EAVLKESENTMWHIEIQEGRLEAFRT 185
             M               E E++   Q       E  ++E E  MW  E      E  R 
Sbjct: 325 EKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE------EKIRE 378

Query: 186 ADR--EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKL-- 241
            D   +E E    R + +  EQ  + QE + + E+    +  K    ++E+  + +K+  
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 242 LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK 301
           LE+  ++ +  +R ++  +     QE++E+M+  E   +R +  +  +   +  ++ L K
Sbjct: 439 LEEMMQDQEEKLREVEEKM-----QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493

Query: 302 FQA--WDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRK 359
            +   W++ +    ++    E++  + +  +  +    + R QE+    R +++E+K+++
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEV----RLWQQEEKMQE 549

Query: 360 QEIISRILKE 369
           QE+  + L+E
Sbjct: 550 QEVRLQELEE 559



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 72/344 (20%), Positives = 155/344 (45%), Gaps = 66/344 (19%)

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA 120
           ++LK+K AE       L++ L  ++    E +L  + ++ +L   +    L+ +QQ  V 
Sbjct: 214 EELKEKNAE-------LQEKLRLVESEKSEIQLNVKDLKRKLERAQL---LLPQQQLQVE 263

Query: 121 AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL 180
           A+   +E          LQ+VS +L A++E                EN +W++  Q+   
Sbjct: 264 ADRLGKE----------LQSVSAKLQAQVE----------------ENELWNLLNQQQEE 297

Query: 181 EAFRTADR---EEVEATGRRLQVRAAEQ-LCREQEALGKVERNRLLRIRKSLNTQKELGL 236
           + +R  ++   +E +   + L++R  E+ + R++E + + E     +  K    ++++  
Sbjct: 298 KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIRE 357

Query: 237 RHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANR 296
           + +K+ E   K  +   +        IREQ++K + E  E M R+ + +          +
Sbjct: 358 QEEKIREQEEKMWRQEEK--------IREQDEKIQ-EQEEEMWRQEEKI--------REQ 400

Query: 297 DTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQE---LEAQKRAFEE 353
           +  R+ + W + K    +     E++  + +  +  R L    + QE    E +++  EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460

Query: 354 EQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLR-DKTW 396
           E+K+++QE      K + +EEK ++Q   T  + +L  + +K W
Sbjct: 461 EEKMQEQEE-----KIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 84/376 (22%), Positives = 165/376 (43%), Gaps = 45/376 (11%)

Query: 22  DERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNL 81
           DE D+LE+ E   +C  +E+   V           D     +KK + E ++ +F  RQ  
Sbjct: 85  DEDDDLEESEDSKQC--KESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKS-SFKKRQ-- 139

Query: 82  SALDKMHEEQELFTEKM--------RGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
              +KM+E+   F +++         GE+ A  Q+R      +E +  + A         
Sbjct: 140 ---EKMNEKNYTFRKRVVIKKPWLRLGEVTA--QKRPENSLLEETLHFDHAVRMGTYIEK 194

Query: 134 AVGRLQAVSRRLFAELENERDLQSRTEAV-----LKESENTMWHIEIQEGRLEAFRTADR 188
                 A S  L+     + +L+ +   +     L ESE +    EIQ    +  R  +R
Sbjct: 195 LTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKS----EIQLNVKDLKRKLER 250

Query: 189 EEVEATGRRLQVRAAEQLCREQEALG-----KVERNRLLRIRKSLNTQKE--LGLRHQKL 241
            ++    ++LQV A ++L +E +++      +VE N L  +   LN Q+E  +  + +K+
Sbjct: 251 AQLLLPQQQLQVEA-DRLGKELQSVSAKLQAQVEENELWNL---LNQQQEEKMWRQEEKI 306

Query: 242 LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK 301
            E   K  +  ++  +      R++EK  E E  E +R + D +   +  I    + +R+
Sbjct: 307 QEQEEKMCEQELKIREQEEKMWRQEEKMHEQE--EKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 302 FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQE 361
                  K    E++++ + + I  Q  + +R    + R QE + Q++ + +E+K+R+Q+
Sbjct: 365 ----QEEKMWRQEEKIREQDEKIQEQEEEMWRQ-EEKIREQEEKRQEKMWRQEKKMREQD 419

Query: 362 IISRILKEEAEEEKRK 377
              R  +EE   ++ K
Sbjct: 420 EKIREQEEEMWRQEEK 435


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 68/342 (19%), Positives = 157/342 (45%), Gaps = 26/342 (7%)

Query: 54  KELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLID 113
           +EL     +L++K     ++   ++ N+  L +  E  +L   + + ++ A     D + 
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEA-----DRLG 268

Query: 114 KQQEAVAAEIATEEEAGNMAAVGRLQAVSR--RLFAELENERDLQSRTEAVLKESENTMW 171
           K+ ++V+A++  + E   +  +   Q   +  R   +++ + +     E  ++E E  MW
Sbjct: 269 KELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMW 328

Query: 172 HIEIQEGRLEAFRTADREEVEATGRRLQ-VRAAEQLCREQEA-LGKVERNRLLRIRKSLN 229
               QE ++       RE+ +   R+ + +R  E+  REQE  + + E     +  K   
Sbjct: 329 R---QEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQE 385

Query: 230 TQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALK 289
            ++E+  + +K+ E   K  +   R  K    ++REQ++K   E  E M R+ + +  L+
Sbjct: 386 QEEEMWRQEEKIREQEEKRQEKMWRQEK----KMREQDEKIR-EQEEEMWRQEEKIRELE 440

Query: 290 GSISANRDTLRKFQAW---DRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEA 346
             +    + LR+ +     +  K +  E+++Q +++ I  Q    +R      + + L+ 
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR------QEKLLKQ 494

Query: 347 QKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHR 388
           +++ +E+E+K+ +QE      +E+ +E++ K Q      R +
Sbjct: 495 EEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQ 536



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 75/370 (20%), Positives = 162/370 (43%), Gaps = 44/370 (11%)

Query: 12  ELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDR 71
           EL     L+E E+ E++    D+K  L+ A+  +        ++L  +AD+L K+     
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQ------QQLQVEADRLGKEL---- 271

Query: 72  TQAFHLRQNLSA-LDKMHEEQELFTE-KMRGELRACRQRRDLIDKQQEAVAAEIATEEEA 129
                  Q++SA L    EE EL+     + E +  RQ   + +++++    E+   E+ 
Sbjct: 272 -------QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQE 324

Query: 130 GNMAAVGRLQAVSRRLFAELENERDLQSRT----EAVLKESENTMWHIEIQEGRLEAFRT 185
             M               E E++   Q       E  ++E E  MW  E      E  R 
Sbjct: 325 EKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE------EKIRE 378

Query: 186 ADR--EEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKL-- 241
            D   +E E    R + +  EQ  + QE + + E+    +  K    ++E+  + +K+  
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 242 LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK 301
           LE+  ++ +  +R ++  +     QE++E+M+  E   +R +  +  +   +  ++ L K
Sbjct: 439 LEEMMQDQEEKLREVEEKM-----QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493

Query: 302 FQA--WDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRK 359
            +   W++ +    ++    E++  + +  +  +    + R QE+    R +++E+K+++
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEV----RLWQQEEKMQE 549

Query: 360 QEIISRILKE 369
           QE+  + L+E
Sbjct: 550 QEVRLQELEE 559



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 84/376 (22%), Positives = 166/376 (44%), Gaps = 45/376 (11%)

Query: 22  DERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNL 81
           DE D+LE+ E   +C  +E+   V           D     +KK + E ++ +F  RQ  
Sbjct: 85  DEDDDLEESEDSKQC--KESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKS-SFKKRQ-- 139

Query: 82  SALDKMHEEQELFTEKM--------RGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMA 133
              +KM+E+   F +++         GE+ A  Q+R      +E +  + A         
Sbjct: 140 ---EKMNEKNYTFRKRVVIKKPWLRLGEVTA--QKRPENSLLEETLHFDHAVRMGTYIEK 194

Query: 134 AVGRLQAVSRRLFAELENERDLQSRTEAV-----LKESENTMWHIEIQEGRLEAFRTADR 188
                 A+S  L+     + +L+ +   +     L ESE +    EIQ    +  R  +R
Sbjct: 195 LTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKS----EIQLNVKDLKRKLER 250

Query: 189 EEVEATGRRLQVRAAEQLCREQEALG-----KVERNRLLRIRKSLNTQKE--LGLRHQKL 241
            ++    ++LQV A ++L +E +++      +VE N L  +   LN Q+E  +  + +K+
Sbjct: 251 AQLLLPQQQLQVEA-DRLGKELQSVSAKLQAQVEENELWNL---LNQQQEEKMWRQEEKI 306

Query: 242 LEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRK 301
            E   K  +  ++  +      R++EK  E E  E +R + D +   +  I    + +R+
Sbjct: 307 QEQEEKMCEQELKIREQEEKMWRQEEKMHEQE--EKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 302 FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQE 361
                  K    E++++ + + I  Q  + +R    + R QE + Q++ + +E+K+R+Q+
Sbjct: 365 ----QEEKMWRQEEKIREQDEKIQEQEEEMWRQ-EEKIREQEEKRQEKMWRQEKKMREQD 419

Query: 362 IISRILKEEAEEEKRK 377
              R  +EE   ++ K
Sbjct: 420 EKIREQEEEMWRQEEK 435



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 72/344 (20%), Positives = 155/344 (45%), Gaps = 66/344 (19%)

Query: 61  DKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVA 120
           ++LK+K AE       L++ L  ++    E +L  + ++ +L   +    L+ +QQ  V 
Sbjct: 214 EELKEKNAE-------LQEKLRLVESEKSEIQLNVKDLKRKLERAQL---LLPQQQLQVE 263

Query: 121 AEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRL 180
           A+   +E          LQ+VS +L A++E                EN +W++  Q+   
Sbjct: 264 ADRLGKE----------LQSVSAKLQAQVE----------------ENELWNLLNQQQEE 297

Query: 181 EAFRTADR---EEVEATGRRLQVRAAEQ-LCREQEALGKVERNRLLRIRKSLNTQKELGL 236
           + +R  ++   +E +   + L++R  E+ + R++E + + E     +  K    ++++  
Sbjct: 298 KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIRE 357

Query: 237 RHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANR 296
           + +K+ E   K  +   +        IREQ++K + E  E M R+ + +          +
Sbjct: 358 QEEKIREQEEKMWRQEEK--------IREQDEKIQ-EQEEEMWRQEEKI--------REQ 400

Query: 297 DTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQE---LEAQKRAFEE 353
           +  R+ + W + K    +     E++  + +  +  R L    + QE    E +++  EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460

Query: 354 EQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLR-DKTW 396
           E+K+++QE      K + +EEK ++Q   T  + +L  + +K W
Sbjct: 461 EEKMQEQEE-----KIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 90/400 (22%), Positives = 171/400 (42%), Gaps = 48/400 (12%)

Query: 16  DALLLEDERDELEDPEFDIK-CLLQEAEDDVDPGHSS---SVKELDTDADKLKKKTAEDR 71
           DAL LE  R+ + D E   K   LQE    V+   S    +VKEL    ++ K    + +
Sbjct: 191 DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQ 250

Query: 72  TQAF--HLRQNLSA----LDKMHEEQELFT-------EKMRGELRACRQRRDLIDKQQEA 118
            QA   HL + L +    L    EE EL+        EKM  +    ++R + I +Q+E 
Sbjct: 251 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEK 310

Query: 119 VAA--EIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRT---EAVLKESENTMWHI 173
           +    E    +E        +++     ++ + E  R+L+ +    E + ++ E      
Sbjct: 311 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 370

Query: 174 EI--QEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQ 231
           +I  QE R E      R+E +   +  ++R  E++ +EQE     +  ++    + +  Q
Sbjct: 371 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQ 430

Query: 232 KELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGS 291
           +E   R ++ + +  K              +IREQE+K   E  E M+ + + +   +G 
Sbjct: 431 EEKMRRQEEKIREQEK--------------KIREQEEKIR-EQEEMMQEQEEKMGEQEGK 475

Query: 292 ISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQE---LEAQK 348
           +      +++       K    E++++ ++K I  Q  +  R      + QE    E ++
Sbjct: 476 MCEQEAKMQE----QEEKMRRQEEKIREQEKKIREQ-EEKIREQEEMMQEQEEKMWEQEE 530

Query: 349 RAFEEEQKLRKQEIISRILKEE-AEEEKRKKQHPPTSARH 387
           +  E+E+K+++QE   R  +E+  E+E R +Q       H
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 92/403 (22%), Positives = 175/403 (43%), Gaps = 76/403 (18%)

Query: 9   PEDELLADALLLEDERDELEDPEFDIKCLL-QEAEDDVDPGHSS-SVKELDTDADKLKKK 66
           PEDE  A     E  R ELE     I+ L  Q+ E  +   +S  +VK+L+ +A  L  +
Sbjct: 95  PEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 154

Query: 67  TAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEI--- 123
             +    A  L Q LSA+    ++ + + E++               K+++A++ E+   
Sbjct: 155 LHDSWKFAGELEQALSAVATQKKKADRYIEELT--------------KERDALSLELYRN 200

Query: 124 -ATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEA 182
             T+EE                       E++ + + +  L ESE +    EIQ    E 
Sbjct: 201 TITDEEL---------------------KEKNAKLQEKLQLVESEKS----EIQLNVKEL 235

Query: 183 FRTADREEVEATGRRLQVRAAEQLCREQEALG-----KVERNRLLRIRKSLNTQKELGLR 237
            R  +R ++    ++LQ  A + L +E +++      +VE N L   R +   ++++  +
Sbjct: 236 KRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQAQVEENELWN-RLNQQQEEKMWRQ 293

Query: 238 HQKLLEDARKNHKVAVRFLKASLGRIREQEKK----EEM--ECHEYMRRRMDAVVALKGS 291
            +K+ E   K        ++    +IREQE+K    EEM  E  E MRR+ + +   +  
Sbjct: 294 EEKIQEREEK--------IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 345

Query: 292 ISA------NRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELE 345
           I         ++ +R+ +   + + ++ EQ  + E++A + +  +  R    + R QE  
Sbjct: 346 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405

Query: 346 AQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHR 388
            Q    E+E+K+ +QE      +EE +E++ K +      R +
Sbjct: 406 MQ----EQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 75/371 (20%), Positives = 149/371 (40%), Gaps = 55/371 (14%)

Query: 38  LQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEK 97
           L EA++ +   H  +   + T A   KKK   + T         +     H  ++     
Sbjct: 48  LAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNP-----ETTTSGGCHSPED----- 97

Query: 98  MRGELRACRQRRDLIDKQQEAVAAEI---ATEEEAGNMAAVGRLQAVSRRLFAELENE-R 153
              E +A  Q ++ + ++ EA    I     ++    MA      AV      +LE E R
Sbjct: 98  ---EQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVK-----QLEGEAR 149

Query: 154 DLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEAL 213
           DL SR     K +           G LE   +A      AT ++   R  E+L +E++AL
Sbjct: 150 DLISRLHDSWKFA-----------GELEQALSA-----VATQKKKADRYIEELTKERDAL 193

Query: 214 GKVERNRLLRIRKSLNTQKELGLRHQKL------LEDARKNHKVAVRFLKASLGRIREQE 267
                   L + ++  T +EL  ++ KL      +E  +   ++ V+ LK  L R +   
Sbjct: 194 S-------LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 246

Query: 268 KKEEMECH-EYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILA 326
            +++++   +++ + + +V A   +     +   +       K    E+++Q  ++ I  
Sbjct: 247 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQE 306

Query: 327 QGRDAFRHLVHQRRRQEL---EAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPT 383
           Q           RR++E+   + +K   +EE    K+E I  + ++  E+EK ++Q    
Sbjct: 307 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 366

Query: 384 SARHRLTLRDK 394
               ++  ++K
Sbjct: 367 QEEEKIREQEK 377


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 90/384 (23%), Positives = 157/384 (40%), Gaps = 54/384 (14%)

Query: 33   DIKCLLQEAEDDVDPGHSSSVKELDTDADK---LKKKTAEDRTQAFHLRQNLSALDKMHE 89
            +I   L + +  +   H  ++ +L  + DK   L K   +   Q   L  +L    K+  
Sbjct: 987  EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046

Query: 90   EQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAEL 149
            + E    K+ G+L+  ++   ++D + +    +   +++   + A+           A +
Sbjct: 1047 DLERAKRKLEGDLKLTQE--SIMDLENDKQQLDERLKKKDFELNALN----------ARI 1094

Query: 150  ENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCRE 209
            E+E+ L S+ +  LKE +     IE  E  LEA RTA R +VE     L     E   R 
Sbjct: 1095 EDEQALGSQLQKKLKELQA---RIEELEEELEAERTA-RAKVEKLRSDLSRELEEISERL 1150

Query: 210  QEALG------KVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRI 263
            +EA G      ++ + R    +K     +E  L+H+      RK H  +V  L   +  +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210

Query: 264  REQEKKEEMECHEY------MRRRMDAVVALKGSISANRDTLRKFQAWDRAKAE------ 311
            +  ++K E E  E+      +   M+ ++  K ++     TL       R+KAE      
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270

Query: 312  --LAEQRVQAE-KKAILAQGRDAFRHLVHQRRR------QELEAQKRAFEEEQK------ 356
              L  QR + + +   L++  D    L+ Q  R      Q+LE  KR  EEE K      
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330

Query: 357  --LRKQEIISRILKEEAEEEKRKK 378
              L+       +L+E+ EEE   K
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAK 1354



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 96/420 (22%), Positives = 179/420 (42%), Gaps = 69/420 (16%)

Query: 20   LEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVK---ELDTDADKLKKKTAE-DRTQAF 75
            LE  R +LE  + +++  L+EAE  ++      ++   E +    ++++K AE D     
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585

Query: 76   HLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATE-EEAGNMAA 134
              R +L  +D +    +  T      LR        + K+ E    E+  +   A  MAA
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALR--------VKKKMEGDLNEMEIQLSHANRMAA 1637

Query: 135  VGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEAT 194
              + Q  S +        +D Q + +  ++ +++   +I I E R    + A+ EE+ A 
Sbjct: 1638 EAQKQVKSLQSLL-----KDTQIQLDDAVRANDDLKENIAIVERRNNLLQ-AELEELRAV 1691

Query: 195  GRRLQVRAAEQLCREQEALGKVERNRLLRIRK-SLNTQK--------ELGLRHQKLLEDA 245
                Q   + +L  EQE +   ER +LL  +  SL  QK        +L    ++ +++ 
Sbjct: 1692 VE--QTERSRKLA-EQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748

Query: 246  RKNHKVAVRFLKASLGRIREQEKKEEMECH-EYMRRRMDAVV---------ALKGSISAN 295
            R   + A + +  +     E +K+++   H E M++ M+  +         A + ++   
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1808

Query: 296  RDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQ 355
            +  L+K +    A+    E  ++AE+K   A+     R    +RR +EL  Q    EE++
Sbjct: 1809 KKQLQKLE----ARVRELENELEAEQKR-NAESVKGMRK--SERRIKELTYQT---EEDR 1858

Query: 356  K--LRKQEIISRI-LK--------EEAEEEK-------RKKQHPPTSARHRLTLRDKTWN 397
            K  LR Q+++ ++ LK        EEAEE+        RK QH    A  R  + +   N
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1918



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 94/394 (23%), Positives = 159/394 (40%), Gaps = 75/394 (19%)

Query: 22   DERDELEDPEFDIKCLLQEAEDDVDPGH--SSSVKELDTDADKLKKKTAEDRTQAFHLRQ 79
            DER + +D  F++  L    ED+   G      +KEL    ++L+++   +RT    + +
Sbjct: 1077 DERLKKKD--FELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEK 1134

Query: 80   NLSALDKMHEEQELFTEKMRG------------ELRACRQRRDLIDK--QQEAVAAEIAT 125
              S L +  EE     E+  G            E    + RRDL +   Q EA AA +  
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL-R 1193

Query: 126  EEEAGNMAAVGRLQAVSRRLFAELENER--------DLQSRTEAVLKESENTMWHIEIQE 177
            ++ A ++A +G      +R+  +LE E+        D+ S  E ++K   N    +E   
Sbjct: 1194 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN----LEKMC 1249

Query: 178  GRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELG-L 236
              LE      R + E T R +    +++   + E     E +R L  +++L +Q   G L
Sbjct: 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE---NGELSRQLDEKEALISQLTRGKL 1306

Query: 237  RHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANR 296
             + + LED ++              ++ E+ K +    H     R D             
Sbjct: 1307 TYTQQLEDLKR--------------QLEEEVKAKNALAHALQSARHDC------------ 1340

Query: 297  DTLR-KFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQ 355
            D LR +++    AKAEL  QRV ++  + +AQ R  +     QR  +  EA+K+  +  Q
Sbjct: 1341 DLLREQYEEETEAKAEL--QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398

Query: 356  KLRKQEIISRILKEEAEEEKRKKQHPPTSARHRL 389
            +            EEA E    K       +HRL
Sbjct: 1399 E-----------AEEAVEAVNAKCSSLEKTKHRL 1421



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 91/432 (21%), Positives = 181/432 (41%), Gaps = 61/432 (14%)

Query: 4    DGSLLPEDELLADALLLEDERDELED----PEFDIKCLLQEAEDDVDPGHS--SSVKELD 57
            +G L    E + D   LE+++ +L++     +F++  L    ED+   G      +KEL 
Sbjct: 1056 EGDLKLTQESIMD---LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112

Query: 58   TDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRG------------ELRAC 105
               ++L+++   +RT    + +  S L +  EE     E+  G            E    
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172

Query: 106  RQRRDLIDK--QQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENER--------DL 155
            + RRDL +   Q EA AA +  ++ A ++A +G      +R+  +LE E+        D+
Sbjct: 1173 KMRRDLEEATLQHEATAAALR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231

Query: 156  QSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGK 215
             S  E ++K   N    +E     LE      R + E T R +    +++   + E    
Sbjct: 1232 TSNMEQIIKAKAN----LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE---N 1284

Query: 216  VERNRLLRIRKSLNTQKELG-LRHQKLLEDARKNHKVAVRFLKASLGRIRE--------- 265
             E +R L  +++L +Q   G L + + LED ++  +  V+   A    ++          
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344

Query: 266  QEKKEEMECHEYMRR---RMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
            ++ +EE E    ++R   + ++ VA +       D +++ +  + AK +LA++  +AE+ 
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVA-QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403

Query: 323  AILAQGRDAFRHLVHQRRRQELE--------AQKRAFEEEQKLRKQEIISRILKEEAEEE 374
                  + +       R + E+E        +   A   ++K R  + I    K++ EE 
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463

Query: 375  KRKKQHPPTSAR 386
            + + +     AR
Sbjct: 1464 QSELESSQKEAR 1475



 Score = 36.6 bits (83), Expect = 0.089
 Identities = 55/238 (23%), Positives = 104/238 (43%), Gaps = 15/238 (6%)

Query: 148  ELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLC 207
            E    ++   ++EA  KE E  M  +  ++  L+    A+++ +     R      +QL 
Sbjct: 855  EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEER-----CDQLI 909

Query: 208  REQEAL-GKV-ERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIRE 265
            + +  L  KV E N  L   + +N   EL  + +KL ED     K  +  L+ +L ++ E
Sbjct: 910  KNKIQLEAKVKEMNERLEDEEEMNA--ELTAKKRKL-EDECSELKRDIDDLELTLAKV-E 965

Query: 266  QEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKF--QAWDRAKAELAEQRVQAEKKA 323
            +EK       + +   M  +  +   ++  +  L++   QA D  +AE  +     + K 
Sbjct: 966  KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025

Query: 324  ILAQGRDAFRHLVHQRR--RQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQ 379
             L Q  D     + Q +  R +LE  KR  E + KL ++ I+     ++  +E+ KK+
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083


>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
           sapiens]
          Length = 955

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 102/453 (22%), Positives = 198/453 (43%), Gaps = 79/453 (17%)

Query: 12  ELLADALLLEDERDEL-EDPEFDIKCLLQEAEDDVD----------PGHSSSVKELDTDA 60
           E+ A    L  E+D L  D E ++K L  + + D++             SS ++EL+ + 
Sbjct: 454 EVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNV 513

Query: 61  DKLKKKTAED---RTQAFHLRQNLSALDKMHEEQ--ELFTEKMRGEL-RACRQRRDLIDK 114
            +LK++  E    R Q    ++N   ++K H +   E     ++ EL +     +  I K
Sbjct: 514 CQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHK 573

Query: 115 QQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIE 174
            +EA+  +   EE+   +  V RLQA       E E +R ++  +E V  E +  M  +E
Sbjct: 574 FEEALKEK---EEQLTRVTEVQRLQAQQADAALE-EFKRQVELNSEKVYAEMKEQMEKVE 629

Query: 175 IQEGRLEAFRTADREE----VEATGRRLQVRAAE-QLCREQEALG-----KVERNRLLRI 224
               R ++ R    +E    +E   +R + +  E +L  EQE          E++ L+R 
Sbjct: 630 ADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRD 689

Query: 225 --RKSLNTQKEL---GLRHQKLLEDARKN------------HKVAVRFLKAS-------- 259
             R+  N +K+L    + H+  +++ +K             HK+    +  +        
Sbjct: 690 HEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLV 749

Query: 260 -LGRIREQEKKEEMECHEYMRRRMDAV-----VALKGSISANRD-TLRKFQAWDRAKAEL 312
            LG +RE+EK+     HE +  ++ A      + LK + +A  + TL K  +  +   + 
Sbjct: 750 ELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKE 809

Query: 313 AEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRA------FEEEQK--LRKQEIIS 364
             Q++ A+   I+A+ +     L  +  +Q+L A++R       FE+E+K  +R  +   
Sbjct: 810 YTQKL-AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAI 868

Query: 365 RILKEEAEEE-------KRKKQHPPTSARHRLT 390
           ++L++E E         ++K QH    ++ ++T
Sbjct: 869 KVLQDELENRSNQVRCAEKKLQHKELESQEQIT 901



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 83/414 (20%), Positives = 161/414 (38%), Gaps = 65/414 (15%)

Query: 20  LEDERDELEDPEFDIKCLLQ----EAEDDVDPGHSSSVKELDTDADKLKKK----TAEDR 71
           L D+ ++ +  +  +K + +    + + ++D G   + K++    + LK+K    T    
Sbjct: 531 LRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE 590

Query: 72  TQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGN 131
            Q    +Q  +AL++   + EL +EK+  E++          +Q E V A++   +    
Sbjct: 591 VQRLQAQQADAALEEFKRQVELNSEKVYAEMK----------EQMEKVEADLTRSKSLR- 639

Query: 132 MAAVGRLQAVSRRLFAELENERDLQSRTEAVLK-ESENTMWHIEIQEGRLEAFRTADREE 190
                  +  S+    +LE+ R    +    LK E E    H+ +Q+   E        E
Sbjct: 640 -------EKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHL-LQQHNAEKDSLVRDHE 691

Query: 191 VEATGRRLQVRAAE---------------QLCREQEALGKVERNRLLRIRKSLNTQK-EL 234
            E      Q+RAA                Q+  + EA     R  L+ +      Q  EL
Sbjct: 692 REIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVEL 751

Query: 235 GLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKE-------------------EMECH 275
           GL  ++  + A + H++ V  LKA   +++ + KK                    E E  
Sbjct: 752 GLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYT 811

Query: 276 EYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHL 335
           + + +    +  L+ +IS+ ++   + Q     + +   Q+ + EKK ++     A +  
Sbjct: 812 QKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIK-- 869

Query: 336 VHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRL 389
           V Q   +    Q R  E++ + ++ E   +I     E E + K   P S R  L
Sbjct: 870 VLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQEL 923


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 74/331 (22%), Positives = 145/331 (43%), Gaps = 40/331 (12%)

Query: 78  RQNLSALDKMH--EEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAV 135
           +Q L+AL +M   + Q+   ++   ++ A +Q+  L  +QQ+ +A  +            
Sbjct: 607 QQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQ----------- 655

Query: 136 GRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIE-------IQEGR----LEAFR 184
            + Q +  R+     ++  + S T +V      ++W ++       + EG     L    
Sbjct: 656 -QFQTLKMRI----SDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDT 710

Query: 185 TADREEVEATGRRLQVRAA--EQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLL 242
           T     +E   +  + +AA  EQ  RE E   K E     R  +    Q+E+  R Q+  
Sbjct: 711 TTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE 770

Query: 243 EDARKNHKVAVRFLKASLGRIREQE-------KKEEMECHEYMRRRMDAVVALKGSISAN 295
              R+  ++A R  + +L R REQE       ++EE +  E   RR++     +      
Sbjct: 771 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 830

Query: 296 RDTLRK--FQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEE 353
            + LRK   +A   A+ E   QR   E +  + +     RH   +R+R+ELE Q++    
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 890

Query: 354 EQKLRKQEIISRILKEEAEEEKRKKQHPPTS 384
            Q+ ++QE + R+ +++ +++  + + P +S
Sbjct: 891 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSS 921



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 37/130 (28%), Positives = 64/130 (49%), Gaps = 17/130 (13%)

Query: 263 IREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKK 322
           +R + ++EE +  E +RR+ + ++  +      R   R+ +   R K E A +R Q E++
Sbjct: 740 MRAKREEEERKRQEELRRQQEEILRRQQEEERKR---REEEELARRKQEEALRR-QREQE 795

Query: 323 AILAQGRDAFRHLVHQRRRQELEAQKRAFE---EEQKLRKQEIISRILKEEAEEEKRKKQ 379
             L + R+       + R+Q+ EA +R  E   EE++ RKQE + R    + EEE  K  
Sbjct: 796 IALRRQRE------EEERQQQEEALRRLEERRREEEERRKQEELLR----KQEEEAAKWA 845

Query: 380 HPPTSARHRL 389
                A+ RL
Sbjct: 846 REEEEAQRRL 855



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 70/348 (20%), Positives = 136/348 (39%), Gaps = 69/348 (19%)

Query: 15   ADALLLEDERDELE------DPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTA 68
            A A  LE ER E E      + E   +  L+  ++++        ++   + +  ++K  
Sbjct: 726  AKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 785

Query: 69   E----DRTQAFHLRQNLSALDKMHEEQELFT-EKMRGELRACRQRRDLIDKQQEAVAAEI 123
            E     R Q   LR+     ++  +E+ L   E+ R E    R++ +L+ KQ+E  AA+ 
Sbjct: 786  EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEE-AAKW 844

Query: 124  ATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAF 183
            A EEE                               EA  +  EN +  +E +  RL   
Sbjct: 845  AREEE-------------------------------EAQRRLEENRL-RMEEEAARLR-- 870

Query: 184  RTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLE 243
                 EE E   + L+V+  ++L R+++     ++  L R+++    Q++  L   KL  
Sbjct: 871  ----HEEEERKRKELEVQRQKELMRQRQQ----QQEALRRLQQQ---QQQQQLAQMKLPS 919

Query: 244  DA----RKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTL 299
             +    + N          SL  I++ E++ E +  E  RR+   +  +K      +   
Sbjct: 920  SSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL--MKALQQQQQQQQ 977

Query: 300  RKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQ 347
            +K   W          +     K++L   ++  R +  Q+++Q+   Q
Sbjct: 978  QKLSGWGNV------SKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1019



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 18/55 (32%), Positives = 33/55 (60%), Gaps = 7/55 (12%)

Query: 336 VHQRRRQELEAQKRAFEEEQKLRKQEIISR----ILKEEAEEEKRKKQHPPTSAR 386
           + Q RR   EA+ RA  EE++ ++QE + R    IL+ + EEE+++++    + R
Sbjct: 731 LEQERR---EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARR 782


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,537,837
Number of Sequences: 37866
Number of extensions: 1450464
Number of successful extensions: 12270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 695
Number of HSP's that attempted gapping in prelim test: 7852
Number of HSP's gapped (non-prelim): 3335
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.