Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 32528297
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform
b [Homo sapiens]
(549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 1101 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 1099 0.0
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 746 0.0
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 729 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 436 e-122
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 433 e-121
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 433 e-121
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 433 e-121
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 427 e-119
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 417 e-116
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 353 2e-97
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 344 1e-94
gi|4502023 AKT2 kinase [Homo sapiens] 287 2e-77
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 285 6e-77
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 284 2e-76
gi|133908623 protein kinase C, iota [Homo sapiens] 268 1e-71
gi|62241015 AKT1 kinase [Homo sapiens] 267 2e-71
gi|62241013 AKT1 kinase [Homo sapiens] 267 2e-71
gi|62241011 AKT1 kinase [Homo sapiens] 267 2e-71
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 263 3e-70
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 263 3e-70
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 263 3e-70
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 260 3e-69
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 260 3e-69
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 258 8e-69
gi|4506067 protein kinase C, alpha [Homo sapiens] 256 4e-68
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 255 8e-68
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 255 8e-68
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 254 1e-67
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 254 1e-67
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 1101 bits (2847), Expect = 0.0
Identities = 549/549 (100%), Positives = 549/549 (100%)
Query: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
Sbjct: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
Query: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
Sbjct: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
Query: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
Sbjct: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
Query: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
Sbjct: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
Query: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
Sbjct: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
Query: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
Sbjct: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
Query: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
Sbjct: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
Query: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
Sbjct: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
Query: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
Sbjct: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
Query: 541 VHRDLKPEV 549
VHRDLKPEV
Sbjct: 541 VHRDLKPEV 549
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 1099 bits (2843), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
Sbjct: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
Query: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
Sbjct: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
Query: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
Sbjct: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
Query: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
Sbjct: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
Query: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
Sbjct: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
Query: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
Sbjct: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
Query: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
Sbjct: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
Query: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
Sbjct: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
Query: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
Sbjct: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
Query: 541 VHRDLKPE 548
VHRDLKPE
Sbjct: 541 VHRDLKPE 548
Score = 129 bits (325), Expect = 5e-30
Identities = 80/260 (30%), Positives = 140/260 (53%), Gaps = 23/260 (8%)
Query: 53 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112
K LG G++ + RK + + +A+K++ K + +T+ E L+ P
Sbjct: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
Query: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172
+V LH F + L+++ +NGGELF + +++ F+E E + ++V A+ H+H +G
Sbjct: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
Query: 173 IIYRDIKLENILL---DSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGD 229
+++RD+K EN+L + N + + DFG ++ + + + C T+ Y AP+++
Sbjct: 540 VVHRDLKPENLLFTDENDNLEIKIIDFGFAR-LKPPDNQPLKTPCFTLHYAAPELL--NQ 596
Query: 230 SGHDKAVDWWSLGVLMYELLTGASPFTVDGEK---NSQAEISRRILKSEPPYPQE----M 282
+G+D++ D WSLGV++Y +L+G PF S EI ++I K + + E +
Sbjct: 597 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV 656
Query: 283 SALAKDLIQRLLMKDPKKRL 302
S AKDLIQ LL DP KRL
Sbjct: 657 SQEAKDLIQGLLTVDPNKRL 676
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 746 bits (1926), Expect = 0.0
Identities = 361/534 (67%), Positives = 442/534 (82%), Gaps = 4/534 (0%)
Query: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
Query: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
Query: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
Query: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
FVAPSILF N AV+ D L+ +RPG VARSAMM+DSPF+Q Y+LDL++ LG+G
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
Query: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
Query: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPE 548
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPE
Sbjct: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPE 534
Score = 110 bits (275), Expect = 3e-24
Identities = 77/259 (29%), Positives = 137/259 (52%), Gaps = 23/259 (8%)
Query: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
LG G++ + R+ +G+ +A+K+L + + +T+ E L + P +
Sbjct: 417 LGQGSFS---VCRRCRQRQSGQEFAVKILSR-------RLEANTQREVAALRLCQSHPNV 466
Query: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHK-LGI 173
V LH + +L+L+ + GGEL H+ ++ F+E E + +V A+ +H+ G+
Sbjct: 467 VNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGV 526
Query: 174 IYRDIKLENILL--DSNGHVV-LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDS 230
++RD+K ENIL D+ G V + DFG ++ + C T++Y AP+++
Sbjct: 527 VHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELL--AQQ 584
Query: 231 GHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKS----EPPYPQEMS 283
G+D++ D WSLGV++Y +L+G PF + G ++ AEI +I + + Q +S
Sbjct: 585 GYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS 644
Query: 284 ALAKDLIQRLLMKDPKKRL 302
AK+L++ LL DP KRL
Sbjct: 645 EEAKELVRGLLTVDPAKRL 663
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 729 bits (1882), Expect = 0.0
Identities = 357/534 (66%), Positives = 436/534 (81%), Gaps = 10/534 (1%)
Query: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
Query: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
Query: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
Query: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
FVAPSILF N AV+ D L+ +RPG VARSAMM Q Y+LDL++ LG+G
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
Query: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
Query: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPE 548
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPE
Sbjct: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPE 528
Score = 110 bits (275), Expect = 3e-24
Identities = 77/259 (29%), Positives = 137/259 (52%), Gaps = 23/259 (8%)
Query: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
LG G++ + R+ +G+ +A+K+L + + +T+ E L + P +
Sbjct: 411 LGQGSFS---VCRRCRQRQSGQEFAVKILSR-------RLEANTQREVAALRLCQSHPNV 460
Query: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHK-LGI 173
V LH + +L+L+ + GGEL H+ ++ F+E E + +V A+ +H+ G+
Sbjct: 461 VNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGV 520
Query: 174 IYRDIKLENILL--DSNGHVV-LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDS 230
++RD+K ENIL D+ G V + DFG ++ + C T++Y AP+++
Sbjct: 521 VHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELL--AQQ 578
Query: 231 GHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKS----EPPYPQEMS 283
G+D++ D WSLGV++Y +L+G PF + G ++ AEI +I + + Q +S
Sbjct: 579 GYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS 638
Query: 284 ALAKDLIQRLLMKDPKKRL 302
AK+L++ LL DP KRL
Sbjct: 639 EEAKELVRGLLTVDPAKRL 657
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 436 bits (1122), Expect = e-122
Identities = 238/546 (43%), Positives = 337/546 (61%), Gaps = 29/546 (5%)
Query: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
E G +SG AG +G + +++ H ++ + EK +FELLKVLG G++GK
Sbjct: 21 ENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGK 75
Query: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQ 122
VFLVRK++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQ
Sbjct: 76 VFLVRKVTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQ 132
Query: 123 TETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182
TE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K EN
Sbjct: 133 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192
Query: 183 ILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLG 242
ILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS G
Sbjct: 193 ILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYG 249
Query: 243 VLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
VLM+E+LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RL
Sbjct: 250 VLMFEMLTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRL 305
Query: 303 GCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPA 362
G GP A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP
Sbjct: 306 GSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPG 365
Query: 363 ALPQS-SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQ 421
P + + +LF+G+SFVA ++ H V++ N+ S
Sbjct: 366 IPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS---------- 415
Query: 422 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNI 481
D + + +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI
Sbjct: 416 --DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNI 472
Query: 482 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 541
+ L +V+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVV
Sbjct: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
Query: 542 HRDLKP 547
HRDLKP
Sbjct: 533 HRDLKP 538
Score = 108 bits (271), Expect = 1e-23
Identities = 76/264 (28%), Positives = 140/264 (53%), Gaps = 23/264 (8%)
Query: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+ + + + +G G+Y + ++ T YA+KV+ K+ K +E E ++L
Sbjct: 416 DGYVVKETIGVGSYSEC---KRCVHKATNMEYAVKVIDKS----KRDPSE----EIEILL 464
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Q P ++TL + ++L+ + + GGEL + +++ F+E E + I +E
Sbjct: 465 RYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 524
Query: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 525 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 583
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
++++ G+D+ D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 584 EVLK--RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGN 640
Query: 280 -QEMSALAKDLIQRLLMKDPKKRL 302
+S AKDL+ ++L DP +RL
Sbjct: 641 WNTVSETAKDLVSKMLHVDPHQRL 664
Score = 83.2 bits (204), Expect = 6e-16
Identities = 47/154 (30%), Positives = 83/154 (53%), Gaps = 18/154 (11%)
Query: 405 VTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-- 459
+T+ ++ K P H++L K LG+GSF + RK S +A+K++ K
Sbjct: 46 ITHHVKAGSEKADP--SHFELL---KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT 100
Query: 460 -----RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
R+ +++I A HP +VKLH F + +L+++ L GG+LF R+ K+
Sbjct: 101 LKVRDRVRTKMERDILA---DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV 157
Query: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPE 548
F+E + + + +L + H+H +G+++RDLKPE
Sbjct: 158 MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPE 191
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 433 bits (1114), Expect = e-121
Identities = 235/540 (43%), Positives = 334/540 (61%), Gaps = 29/540 (5%)
Query: 9 GGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRK 68
G +G D +G + +++ H ++ + EK +FELLKVLG G++GKVFLVRK
Sbjct: 36 GPGSGPQRDSDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGKVFLVRK 90
Query: 69 ISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLH 128
++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQTE KL+
Sbjct: 91 VTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQTEGKLY 147
Query: 129 LILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN 188
LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K ENILLD
Sbjct: 148 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE 207
Query: 189 GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYEL 248
GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS GVLM+E+
Sbjct: 208 GHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYGVLMFEM 264
Query: 249 LTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRD 308
LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RLG GP
Sbjct: 265 LTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 320
Query: 309 ADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQS- 367
A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP P +
Sbjct: 321 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAG 380
Query: 368 SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDL 427
+ +LF+G+SFVA ++ H V++ N+ S D +
Sbjct: 381 AHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS------------DGYV 428
Query: 428 KDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEV 487
+ +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI+ L +V
Sbjct: 429 VKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNIITLKDV 487
Query: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547
+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVVHRDLKP
Sbjct: 488 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 547
Score = 108 bits (271), Expect = 1e-23
Identities = 76/264 (28%), Positives = 140/264 (53%), Gaps = 23/264 (8%)
Query: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+ + + + +G G+Y + ++ T YA+KV+ K+ K +E E ++L
Sbjct: 425 DGYVVKETIGVGSYSEC---KRCVHKATNMEYAVKVIDKS----KRDPSE----EIEILL 473
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Q P ++TL + ++L+ + + GGEL + +++ F+E E + I +E
Sbjct: 474 RYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 533
Query: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 534 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 592
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
++++ G+D+ D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 593 EVLK--RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGN 649
Query: 280 -QEMSALAKDLIQRLLMKDPKKRL 302
+S AKDL+ ++L DP +RL
Sbjct: 650 WNTVSETAKDLVSKMLHVDPHQRL 673
Score = 83.2 bits (204), Expect = 6e-16
Identities = 47/154 (30%), Positives = 83/154 (53%), Gaps = 18/154 (11%)
Query: 405 VTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-- 459
+T+ ++ K P H++L K LG+GSF + RK S +A+K++ K
Sbjct: 55 ITHHVKAGSEKADP--SHFELL---KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT 109
Query: 460 -----RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
R+ +++I A HP +VKLH F + +L+++ L GG+LF R+ K+
Sbjct: 110 LKVRDRVRTKMERDILA---DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV 166
Query: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPE 548
F+E + + + +L + H+H +G+++RDLKPE
Sbjct: 167 MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPE 200
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 433 bits (1113), Expect = e-121
Identities = 235/507 (46%), Positives = 326/507 (64%), Gaps = 24/507 (4%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 117
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 118 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 176
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 177 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 235
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 236 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 289
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 290 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 349
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 350 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 409
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 410 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 456
Query: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 457 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 516
Query: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKP 547
AS ++ + + ++H GVVHRDLKP
Sbjct: 517 ASDVLCTITKTMDYLHSQGVVHRDLKP 543
Score = 106 bits (265), Expect = 5e-23
Identities = 83/323 (25%), Positives = 161/323 (49%), Gaps = 30/323 (9%)
Query: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+ +E+ + +G G+Y + ++ T YA+K++ K+ K +E E ++L
Sbjct: 421 DGYEIKEDIGVGSYS---VCKRCVHKATDTEYAVKIIDKS----KRDPSE----EIEILL 469
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Q P ++TL + ++L+++ + GGEL + ++ F+E E + I ++
Sbjct: 470 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 529
Query: 167 HLHKLGIIYRDIKLENILL-DSNG---HVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
+LH G+++RD+K NIL D +G + + DFG +K+ A + C T ++AP
Sbjct: 530 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAP 588
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
++++ G+D A D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 589 EVLK--RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGN 645
Query: 280 -QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
+S AKD++ ++L DP +RL A ++ +H + +N + L+ ++ +
Sbjct: 646 WDSISDAAKDVVSKMLHVDPHQRL-----TAMQVLKHPWV--VNREYLSPNQLSRQDVHL 698
Query: 339 IRDELDVSNFAEEFTEMDPTYSP 361
++ + + FA T P P
Sbjct: 699 VKGAMAATYFALNRTPQAPRLEP 721
Score = 83.2 bits (204), Expect = 6e-16
Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 13/129 (10%)
Query: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
K LG+GS+ + RK + Q +A+K++ K R+ + +++I A HP
Sbjct: 71 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV---NHP 127
Query: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +G
Sbjct: 128 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 187
Query: 540 VVHRDLKPE 548
+++RDLKPE
Sbjct: 188 IIYRDLKPE 196
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 433 bits (1113), Expect = e-121
Identities = 235/507 (46%), Positives = 326/507 (64%), Gaps = 24/507 (4%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 109
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 110 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 168
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 169 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 227
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 228 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 281
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 341
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 401
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 402 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 448
Query: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 449 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 508
Query: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKP 547
AS ++ + + ++H GVVHRDLKP
Sbjct: 509 ASDVLCTITKTMDYLHSQGVVHRDLKP 535
Score = 106 bits (265), Expect = 5e-23
Identities = 83/323 (25%), Positives = 161/323 (49%), Gaps = 30/323 (9%)
Query: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+ +E+ + +G G+Y + ++ T YA+K++ K+ K +E E ++L
Sbjct: 413 DGYEIKEDIGVGSYS---VCKRCVHKATDTEYAVKIIDKS----KRDPSE----EIEILL 461
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Q P ++TL + ++L+++ + GGEL + ++ F+E E + I ++
Sbjct: 462 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 521
Query: 167 HLHKLGIIYRDIKLENILL-DSNG---HVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
+LH G+++RD+K NIL D +G + + DFG +K+ A + C T ++AP
Sbjct: 522 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAG-NGLLMTPCYTANFVAP 580
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP--- 279
++++ G+D A D WSLG+L+Y +L G +PF +G ++ EI RI +
Sbjct: 581 EVLK--RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGN 637
Query: 280 -QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
+S AKD++ ++L DP +RL A ++ +H + +N + L+ ++ +
Sbjct: 638 WDSISDAAKDVVSKMLHVDPHQRL-----TAMQVLKHPWV--VNREYLSPNQLSRQDVHL 690
Query: 339 IRDELDVSNFAEEFTEMDPTYSP 361
++ + + FA T P P
Sbjct: 691 VKGAMAATYFALNRTPQAPRLEP 713
Score = 83.2 bits (204), Expect = 6e-16
Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 13/129 (10%)
Query: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
K LG+GS+ + RK + Q +A+K++ K R+ + +++I A HP
Sbjct: 63 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV---NHP 119
Query: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +G
Sbjct: 120 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 179
Query: 540 VVHRDLKPE 548
+++RDLKPE
Sbjct: 180 IIYRDLKPE 188
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 427 bits (1097), Expect = e-119
Identities = 239/554 (43%), Positives = 334/554 (60%), Gaps = 42/554 (7%)
Query: 11 AAGTSADGGDGGEQLL------------TVKHELRTANLTGHA----EKVGIENFELLKV 54
A + +D + G+Q++ T + ++ +T H EK FELLKV
Sbjct: 14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKV 73
Query: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
LG G++GKVFLV+KISG D +LYAMKVLKKAT+ K + T+ ER +L + PF+
Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNH-PFI 130
Query: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGII 174
V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ LAL+HLH LGII
Sbjct: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190
Query: 175 YRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK 234
YRD+K ENILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH +
Sbjct: 191 YRDLKPENILLDEEGHIKLTDFGLSKESI-DHEKKAYSFCGTVEYMAPEVV--NRRGHTQ 247
Query: 235 AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLL 294
+ DWWS GVLM+E+LTG PF + + E ILK++ PQ +S A+ L++ L
Sbjct: 248 SADWWSFGVLMFEMLTGTLPF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
Query: 295 MKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTE 354
++P RLG GP +EIK H FF I+W+ L +++ PFKP D F EFT
Sbjct: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTA 363
Query: 355 MDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAM 413
P SP P ++ +LF+G+SFVA I ++ GV ++ +
Sbjct: 364 KTPKDSPGIPPSANAHQLFRGFSFVA-----------ITSDDESQAMQTVGVHSIVQQLH 412
Query: 414 MKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK 473
F Y++ + +G GS+S+C++C+HK +N FAVKII K T+ EI L
Sbjct: 413 RNSIQFTDGYEV---KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILL 468
Query: 474 LCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVS 533
HPNI+ L +V+ D + ++V EL+ GGEL ++I ++K FSE EAS ++ + V
Sbjct: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
Query: 534 HMHDVGVVHRDLKP 547
++H GVVHRDLKP
Sbjct: 529 YLHAQGVVHRDLKP 542
Score = 115 bits (288), Expect = 1e-25
Identities = 92/335 (27%), Positives = 165/335 (49%), Gaps = 34/335 (10%)
Query: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+ +E+ + +G G+Y + ++ T +A+K++ K+ K TE E ++L
Sbjct: 420 DGYEVKEDIGVGSYS---VCKRCIHKATNMEFAVKIIDKS----KRDPTE----EIEILL 468
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Q P ++TL + ++++ + + GGEL + +++ F+E E + I +E
Sbjct: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
Query: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 529 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 587
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI----LKSEPPY 278
++++ G+D A D WSLGVL+Y +LTG +PF +G ++ EI RI Y
Sbjct: 588 EVLK--RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGY 644
Query: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
+S AKDL+ ++L DP +RL A + H + ++WD L ++ P
Sbjct: 645 WNSVSDTAKDLVSKMLHVDPHQRL-----TAALVLRHPWI--VHWDQLPQYQLNRQDAP- 696
Query: 339 IRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQ 373
L A ++ ++ SP P L Q
Sbjct: 697 ---HLVKGAMAATYSALNRNQSPVLEPVGRSTLAQ 728
Score = 81.6 bits (200), Expect = 2e-15
Identities = 44/130 (33%), Positives = 75/130 (57%), Gaps = 15/130 (11%)
Query: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCE-GH 478
K LG+GSF + +K + Q +A+K++ K R+ +++I L E H
Sbjct: 72 KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDI----LVEVNH 127
Query: 479 PNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 538
P IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +
Sbjct: 128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSL 187
Query: 539 GVVHRDLKPE 548
G+++RDLKPE
Sbjct: 188 GIIYRDLKPE 197
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 417 bits (1071), Expect = e-116
Identities = 241/508 (47%), Positives = 323/508 (63%), Gaps = 29/508 (5%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G++GKVFLVRK +G D G+LYAMKVLKKA++ K + T+ E
Sbjct: 66 EKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKME 123
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG++FT LS+ FTE +V+ Y+ E+
Sbjct: 124 RDILVEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 182
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH+LGI+YRD+K ENILLD GH+ LTDFGLSKE V D+ ++AYSFCGT+EYMA
Sbjct: 183 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV-DQEKKAYSFCGTVEYMA 241
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG PF + + E ILK++ PQ
Sbjct: 242 PEVV--NRRGHSQSADWWSYGVLMFEMLTGTLPF----QGKDRNETMNMILKAKLGMPQF 295
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+SA A+ L++ L ++P RL G +EIK HLFF I+WD L ++V PFKP
Sbjct: 296 LSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQS--SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMG 399
D F EFT P SP LP S + +LF+G+SFVA SI + I
Sbjct: 354 PDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPI 412
Query: 400 VERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISK 459
V+ G N A+ F + Y+L + +G GS+S+C++C+H +N FAVKII K
Sbjct: 413 VQING--NAAQ--------FGEVYEL---KEDIGVGSYSVCKRCIHATTNMEFAVKIIDK 459
Query: 460 RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSET 519
+ + +EI L HPNI+ L +VF D + +LV +L+ GGEL +RI K+K FSE
Sbjct: 460 -SKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSER 518
Query: 520 EASYIMRKLVSAVSHMHDVGVVHRDLKP 547
EAS I+ + V ++H GVVHRDLKP
Sbjct: 519 EASDILYVISKTVDYLHCQGVVHRDLKP 546
Score = 106 bits (265), Expect = 5e-23
Identities = 85/298 (28%), Positives = 149/298 (50%), Gaps = 29/298 (9%)
Query: 26 LTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKK 85
+T + L + G+A + G E +EL + +G G+Y + ++ T +A+K++ K
Sbjct: 404 ITSANVLPIVQINGNAAQFG-EVYELKEDIGVGSYS---VCKRCIHATTNMEFAVKIIDK 459
Query: 86 ATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQ 145
+ K +E E ++L Q P ++TL F ++L+ D + GGEL + +
Sbjct: 460 S----KRDPSE----EIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILK 511
Query: 146 RERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL----DSNGHVVLTDFGLSKE 201
++ F+E E + I +++LH G+++RD+K NIL S + + DFG +K+
Sbjct: 512 QKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 571
Query: 202 FVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEK 261
+ E + C T ++AP+++ G+D A D WSLGVL Y +L G +PF +G
Sbjct: 572 -LRGENGLLLTPCYTANFVAPEVLM--QQGYDAACDIWSLGVLFYTMLAGYTPF-ANGPN 627
Query: 262 NSQAEISRRILKSEPPYP----QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEH 315
++ EI RI + +S AKDL+ +L DP +R A++I +H
Sbjct: 628 DTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY-----TAEQILKH 680
Score = 81.3 bits (199), Expect = 2e-15
Identities = 45/130 (34%), Positives = 75/130 (57%), Gaps = 15/130 (11%)
Query: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCE-GH 478
K LG+GSF + RK + Q +A+K++ K R+ +++I L E H
Sbjct: 77 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI----LVEVNH 132
Query: 479 PNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 538
P IVKLH F + +L+++ L GG++F R+ K+ F+E + + + +L A+ H+H +
Sbjct: 133 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 192
Query: 539 GVVHRDLKPE 548
G+V+RDLKPE
Sbjct: 193 GIVYRDLKPE 202
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 353 bits (907), Expect = 2e-97
Identities = 190/387 (49%), Positives = 260/387 (67%), Gaps = 14/387 (3%)
Query: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKH----ELRTANLTGHAEKVGIENFELLKVLGTG 58
E+ GG S D G G L ++H E+ ++ EK+ E FELL+VLG G
Sbjct: 41 EDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKG 100
Query: 59 AYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLH 118
YGKVF VRK++G +TGK++AMKVLKKA IV+ AK T HT+ ER +LE ++ PF+V L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLI 159
Query: 119 YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDI 178
YAFQT KL+LIL+Y++GGELF L + F E Y+ EI +AL HLH+ GIIYRD+
Sbjct: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
Query: 179 KLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDW 238
K ENI+L+ GHV LTDFGL KE + D T ++FCGTIEYMAP+I+ SGH++AVDW
Sbjct: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTV-THTFCGTIEYMAPEILM--RSGHNRAVDW 276
Query: 239 WSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDP 298
WSLG LMY++LTGA PFT + K + +ILK + P ++ A+DL+++LL ++
Sbjct: 277 WSLGALMYDMLTGAPPFTGENRKKT----IDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
Query: 299 KKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPT 358
RLG GP DA E++ H FF+ INW++L A+KV PFKP+++ E DVS F +FT P
Sbjct: 333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPV 392
Query: 359 YSP--AALPQSSEKLFQGYSFVAPSIL 383
SP + L +S+ ++F G+++VAPS+L
Sbjct: 393 DSPDDSTLSESANQVFLGFTYVAPSVL 419
Score = 68.6 bits (166), Expect = 1e-11
Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 6/122 (4%)
Query: 433 GEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG------HPNIVKLHE 486
G G RK + + FA+K++ K M K+ K HP IV L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
Query: 487 VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546
F +L++E L+GGELF +++++ F E A + + ++ A+ H+H G+++RDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 547 PE 548
PE
Sbjct: 221 PE 222
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 344 bits (883), Expect = 1e-94
Identities = 181/355 (50%), Positives = 244/355 (68%), Gaps = 10/355 (2%)
Query: 31 ELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQ 90
EL ++ E++G FELL+VLG G YGKVF VRK+ G + GK+YAMKVL+KA IV+
Sbjct: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
Query: 91 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150
AK T HTR ER +LE ++ PF+V L YAFQT KL+LIL+ ++GGELFTHL + F
Sbjct: 109 NAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
Query: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 210
E Y+ EI LAL HLH GIIYRD+K ENI+L S GH+ LTDFGL KE + E
Sbjct: 168 EDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVT 226
Query: 211 YSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRR 270
++FCGTIEYMAP+I+ SGH++AVDWWSLG LMY++LTG+ PFT + K + +I R
Sbjct: 227 HTFCGTIEYMAPEIL--VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG 284
Query: 271 ILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKK 330
L + PPY ++ A+DL+++ L ++P +R+G GP DA +++ H FF+ +NWDDL A +
Sbjct: 285 KL-ALPPY---LTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
Query: 331 VPAPFKPVIRDELDVSNFAEEFTEMDPTYSP--AALPQSSEKLFQGYSFVAPSIL 383
V PF+P ++ E DVS F FT P SP AL +S+ + F G+++VAPS+L
Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
Score = 64.7 bits (156), Expect = 2e-10
Identities = 38/123 (30%), Positives = 66/123 (53%), Gaps = 8/123 (6%)
Query: 433 GEGSFSICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHPNIVKLH 485
G G RK + +A+K++ K + A+T+ E L+ + HP IV+L
Sbjct: 77 GYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELA 135
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F +L++E L+GGELF ++++ F E A + + ++ A+ H+H G+++RDL
Sbjct: 136 YAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDL 195
Query: 546 KPE 548
KPE
Sbjct: 196 KPE 198
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 287 bits (734), Expect = 2e-77
Identities = 151/319 (47%), Positives = 204/319 (63%), Gaps = 12/319 (3%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
KV + +F+ LK+LG G +GKV LVR+ + TG+ YAMK+L+K I+ K + HT TE
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIAKDEVA-HTVTES 201
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L YAFQT +L +++Y NGGELF HLS+ FTE + Y EIV
Sbjct: 202 RVLQNTRH-PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260
Query: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
ALE+LH ++YRDIKLEN++LD +GH+ +TDFGL KE ++D +FCGT EY+AP
Sbjct: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK-TFCGTPEYLAP 319
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEM 282
+++ D G +AVDWW LGV+MYE++ G PF + IL E +P+ +
Sbjct: 320 EVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPF----YNQDHERLFELILMEEIRFPRTL 373
Query: 283 SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDE 342
S AK L+ LL KDPK+RLG GP DA E+ EH FF INW D+ KK+ PFKP + E
Sbjct: 374 SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSE 433
Query: 343 LDVSNFAEEFTEMDPTYSP 361
+D F +EFT T +P
Sbjct: 434 VDTRYFDDEFTAQSITITP 452
Score = 63.9 bits (154), Expect = 4e-10
Identities = 55/191 (28%), Positives = 86/191 (45%), Gaps = 11/191 (5%)
Query: 365 PQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPG-VTNVARSAMMKDSPFYQHY 423
P E+ + VA S+ K+ A DP+ + G T A+ K
Sbjct: 93 PDEREEWMRAIQMVANSL--KQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMN 150
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEG 477
D D K LG+G+F K + + +A+KI+ K + A+T E L+
Sbjct: 151 DFDYL-KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR- 208
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
HP + L F VME NGGELF + +++ F+E A + ++VSA+ ++H
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
Query: 538 VGVVHRDLKPE 548
VV+RD+K E
Sbjct: 269 RDVVYRDIKLE 279
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 285 bits (730), Expect = 6e-77
Identities = 157/347 (45%), Positives = 218/347 (62%), Gaps = 15/347 (4%)
Query: 24 QLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVL 83
Q+ + E A+ T H K + +F+ LK+LG G +GKV LVR+ + +GK YAMK+L
Sbjct: 124 QIDNIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKIL 179
Query: 84 KKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHL 143
KK I+ K + HT TE +VL++ R PFL +L Y+FQT+ +L +++Y+NGGELF HL
Sbjct: 180 KKEVIIAKDEVA-HTLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHL 237
Query: 144 SQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFV 203
S+ F+E + Y EIV AL++LH I+YRD+KLEN++LD +GH+ +TDFGL KE +
Sbjct: 238 SRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 204 ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKN 262
D +FCGT EY+AP+++ D G +AVDWW LGV+MYE++ G PF D EK
Sbjct: 298 TDAATMK-TFCGTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK- 353
Query: 263 SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKIN 322
+ IL + +P+ +S+ AK L+ LL+KDP KRLG GP DA EI H FF +N
Sbjct: 354 ----LFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVN 409
Query: 323 WDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE 369
W D+ KK+ PFKP + E D F EEFT T +P Q S+
Sbjct: 410 WQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
Score = 63.5 bits (153), Expect = 5e-10
Identities = 42/125 (33%), Positives = 65/125 (52%), Gaps = 7/125 (5%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K LG+G+F K S + +A+KI+ K + A+T E LK HP +
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTS 210
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
L F + VME +NGGELF + +++ FSE + ++VSA+ ++H +V+R
Sbjct: 211 LKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYR 270
Query: 544 DLKPE 548
DLK E
Sbjct: 271 DLKLE 275
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 284 bits (726), Expect = 2e-76
Identities = 155/339 (45%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 24 QLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVL 83
Q+ + E A+ T H K + +F+ LK+LG G +GKV LVR+ + +GK YAMK+L
Sbjct: 124 QIDNIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKIL 179
Query: 84 KKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHL 143
KK I+ K + HT TE +VL++ R PFL +L Y+FQT+ +L +++Y+NGGELF HL
Sbjct: 180 KKEVIIAKDEVA-HTLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHL 237
Query: 144 SQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFV 203
S+ F+E + Y EIV AL++LH I+YRD+KLEN++LD +GH+ +TDFGL KE +
Sbjct: 238 SRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 204 ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKN 262
D +FCGT EY+AP+++ D G +AVDWW LGV+MYE++ G PF D EK
Sbjct: 298 TDAATMK-TFCGTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK- 353
Query: 263 SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKIN 322
+ IL + +P+ +S+ AK L+ LL+KDP KRLG GP DA EI H FF +N
Sbjct: 354 ----LFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVN 409
Query: 323 WDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP 361
W D+ KK+ PFKP + E D F EEFT T +P
Sbjct: 410 WQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 63.5 bits (153), Expect = 5e-10
Identities = 42/125 (33%), Positives = 65/125 (52%), Gaps = 7/125 (5%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K LG+G+F K S + +A+KI+ K + A+T E LK HP +
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTS 210
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
L F + VME +NGGELF + +++ FSE + ++VSA+ ++H +V+R
Sbjct: 211 LKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYR 270
Query: 544 DLKPE 548
DLK E
Sbjct: 271 DLKLE 275
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 268 bits (685), Expect = 1e-71
Identities = 141/370 (38%), Positives = 227/370 (61%), Gaps = 16/370 (4%)
Query: 23 EQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKV 82
+Q+ K + T + +G+++F+LL+V+G G+Y KV LVR T ++YAMKV
Sbjct: 228 DQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRL---KKTDRIYAMKV 284
Query: 83 LKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTH 142
+KK +V + + +TE+ V E PFLV LH FQTE++L +++Y+NGG+L H
Sbjct: 285 VKKE-LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFH 343
Query: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202
+ ++ + E + Y EI LAL +LH+ GIIYRD+KL+N+LLDS GH+ LTD+G+ KE
Sbjct: 344 MQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEG 403
Query: 203 VADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDG--- 259
+ + +FCGT Y+AP+I+RG D G +VDWW+LGVLM+E++ G SPF + G
Sbjct: 404 LR-PGDTTSTFCGTPNYIAPEILRGEDYGF--SVDWWALGVLMFEMMAGRSPFDIVGSSD 460
Query: 260 --EKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHL 316
++N++ + + IL+ + P+ +S A +++ L KDPK+RLGC P+ +I+ H
Sbjct: 461 NPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
Query: 317 FFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQ 373
FF+ ++WD + K+V PFKP I E + NF +FT +P + + + F+
Sbjct: 521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 580
Query: 374 GYSFVAPSIL 383
G+ ++ P ++
Sbjct: 581 GFEYINPLLM 590
Score = 67.0 bits (162), Expect = 4e-11
Identities = 39/152 (25%), Positives = 75/152 (49%), Gaps = 9/152 (5%)
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
E N S S Q +DL + +G GS++ KK+++ +A+K++ K
Sbjct: 232 EEKEAMNTRESGKASSSLGLQDFDLL---RVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 288
Query: 461 MEAN------TQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
+ + Q E + HP +V LH F + F V+E +NGG+L +++++
Sbjct: 289 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQR 348
Query: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546
E A + ++ A++++H+ G+++RDLK
Sbjct: 349 KLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 2e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 59.7 bits (143), Expect = 7e-09
Identities = 43/127 (33%), Positives = 64/127 (50%), Gaps = 10/127 (7%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPE 548
+RDLK E
Sbjct: 272 YRDLKLE 278
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 2e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 59.7 bits (143), Expect = 7e-09
Identities = 43/127 (33%), Positives = 64/127 (50%), Gaps = 10/127 (7%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPE 548
+RDLK E
Sbjct: 272 YRDLKLE 278
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 2e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 59.7 bits (143), Expect = 7e-09
Identities = 43/127 (33%), Positives = 64/127 (50%), Gaps = 10/127 (7%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPE 548
+RDLK E
Sbjct: 272 YRDLKLE 278
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 263 bits (672), Expect = 3e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 116
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 235
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 236 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 293
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 294 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 353
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 354 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 68 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 126
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 127 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 186
Query: 538 VGVVHRDLK 546
G+++RDLK
Sbjct: 187 RGIIYRDLK 195
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 263 bits (672), Expect = 3e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 116
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 235
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 236 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 293
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 294 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 353
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 354 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 68 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 126
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 127 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 186
Query: 538 VGVVHRDLK 546
G+++RDLK
Sbjct: 187 RGIIYRDLK 195
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 263 bits (672), Expect = 3e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 299
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 300 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 359
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 360 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 418
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 419 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 476
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 477 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 536
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 537 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 586
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 251 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 309
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 310 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 369
Query: 538 VGVVHRDLK 546
G+++RDLK
Sbjct: 370 RGIIYRDLK 378
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 260 bits (664), Expect = 3e-69
Identities = 148/336 (44%), Positives = 199/336 (59%), Gaps = 18/336 (5%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEH 107
+F+ LKV+G G YGKV L ++ S G YA+KVL+K +I++K K H ER VL
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK-KEQSHIMAERSVLLK 89
Query: 108 IRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEH 167
+ PFLV L Y+FQT KL+ +LDY+NGGELF HL + RF E + Y E+ A+ +
Sbjct: 90 NVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGY 149
Query: 168 LHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG 227
LH L IIYRD+K ENILLD GHVVLTDFGL KE V E + +FCGT EY+AP+++R
Sbjct: 150 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE-DTTSTFCGTPEYLAPEVLR- 207
Query: 228 GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAK 287
+D+AVDWW LG ++YE+L G PF +++ IL P + A
Sbjct: 208 -KEPYDRAVDWWCLGAVLYEMLHGLPPF----YSQDVSQMYENILHQPLQIPGGRTVAAC 262
Query: 288 DLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSN 347
DL+Q LL KD ++RLG D EIK H+FF INWDDL K++ PF P + D+ +
Sbjct: 263 DLLQSLLHKDQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 348 FAEEFTEMDPTYSPAALPQS------SEKLFQGYSF 377
F EFT+ + S P + + F G+S+
Sbjct: 322 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
Score = 68.2 bits (165), Expect = 2e-11
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 7/138 (5%)
Query: 417 SPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEIT 470
+P Q D D K +G+G++ K +AVK++ K+ +++ E +
Sbjct: 27 NPNAQPTDFDFL-KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 85
Query: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVS 530
L HP +V L F + V++ +NGGELF +++++ F E A + ++ S
Sbjct: 86 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 145
Query: 531 AVSHMHDVGVVHRDLKPE 548
A+ ++H + +++RDLKPE
Sbjct: 146 AIGYLHSLNIIYRDLKPE 163
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 260 bits (664), Expect = 3e-69
Identities = 148/336 (44%), Positives = 199/336 (59%), Gaps = 18/336 (5%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEH 107
+F+ LKV+G G YGKV L ++ S G YA+KVL+K +I++K K H ER VL
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK-KEQSHIMAERSVLLK 149
Query: 108 IRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEH 167
+ PFLV L Y+FQT KL+ +LDY+NGGELF HL + RF E + Y E+ A+ +
Sbjct: 150 NVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGY 209
Query: 168 LHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG 227
LH L IIYRD+K ENILLD GHVVLTDFGL KE V E + +FCGT EY+AP+++R
Sbjct: 210 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE-DTTSTFCGTPEYLAPEVLR- 267
Query: 228 GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAK 287
+D+AVDWW LG ++YE+L G PF +++ IL P + A
Sbjct: 268 -KEPYDRAVDWWCLGAVLYEMLHGLPPF----YSQDVSQMYENILHQPLQIPGGRTVAAC 322
Query: 288 DLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSN 347
DL+Q LL KD ++RLG D EIK H+FF INWDDL K++ PF P + D+ +
Sbjct: 323 DLLQSLLHKDQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 348 FAEEFTEMDPTYSPAALPQS------SEKLFQGYSF 377
F EFT+ + S P + + F G+S+
Sbjct: 382 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
Score = 68.2 bits (165), Expect = 2e-11
Identities = 38/138 (27%), Positives = 71/138 (51%), Gaps = 7/138 (5%)
Query: 417 SPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEIT 470
+P Q D D K +G+G++ K +AVK++ K+ +++ E +
Sbjct: 87 NPNAQPTDFDFL-KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 145
Query: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVS 530
L HP +V L F + V++ +NGGELF +++++ F E A + ++ S
Sbjct: 146 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 205
Query: 531 AVSHMHDVGVVHRDLKPE 548
A+ ++H + +++RDLKPE
Sbjct: 206 AIGYLHSLNIIYRDLKPE 223
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 258 bits (660), Expect = 8e-69
Identities = 139/349 (39%), Positives = 207/349 (59%), Gaps = 16/349 (4%)
Query: 39 GHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT 98
G+ +++ + +F L VLG G++GKV L + T +LYA+K+LKK ++Q E T
Sbjct: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECT 387
Query: 99 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYV 158
E++VL + PFL LH FQT +L+ +++Y+NGG+L H+ Q RF E Y
Sbjct: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447
Query: 159 GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIE 218
EI + L L GIIYRD+KL+N++LDS GH+ + DFG+ KE + D +FCGT +
Sbjct: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV-TTKTFCGTPD 506
Query: 219 YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 278
Y+AP+I+ G K+VDWW+ GVL+YE+L G +PF E + E+ + I++ Y
Sbjct: 507 YIAPEIIAYQPYG--KSVDWWAFGVLLYEMLAGQAPF----EGEDEDELFQSIMEHNVAY 560
Query: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
P+ MS A + + L+ K P KRLGCGP +IKEH FF+ I+W+ L K++ P+KP
Sbjct: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620
Query: 339 IRDELDVSNFAEEFT----EMDPTYSPAALPQSSEKLFQGYSFVAPSIL 383
RD+ D SNF +EFT E+ PT + + F G+S+ P +
Sbjct: 621 ARDKRDTSNFDKEFTRQPVELTPT-DKLFIMNLDQNEFAGFSYTNPEFV 668
Score = 56.6 bits (135), Expect = 6e-08
Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 6/121 (4%)
Query: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEGHPNIVKLH 485
LG+GSF K +++ +AVKI+ K + T E L L P + +LH
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F + VME +NGG+L I++ F E A + ++ + + G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 546 K 546
K
Sbjct: 468 K 468
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 256 bits (654), Expect = 4e-68
Identities = 140/385 (36%), Positives = 223/385 (57%), Gaps = 17/385 (4%)
Query: 2 EEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYG 61
+EEG A G G ++++ + + + + ++V + +F L VLG G++G
Sbjct: 294 DEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPS--NNLDRVKLTDFNFLMVLGKGSFG 351
Query: 62 KVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAF 121
KV L + T +LYA+K+LKK ++Q E T E++VL + + PFL LH F
Sbjct: 352 KVMLADR---KGTEELYAIKILKKDVVIQD-DDVECTMVEKRVLALLDKPPFLTQLHSCF 407
Query: 122 QTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLE 181
QT +L+ +++Y+NGG+L H+ Q +F E + Y EI + L LHK GIIYRD+KL+
Sbjct: 408 QTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLD 467
Query: 182 NILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 241
N++LDS GH+ + DFG+ KE + D +FCGT +Y+AP+I+ G K+VDWW+
Sbjct: 468 NVMLDSEGHIKIADFGMCKEHMMDGV-TTRTFCGTPDYIAPEIIAYQPYG--KSVDWWAY 524
Query: 242 GVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKR 301
GVL+YE+L G PF DGE + E+ + I++ YP+ +S A + + L+ K P KR
Sbjct: 525 GVLLYEMLAGQPPF--DGE--DEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKR 580
Query: 302 LGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP 361
LGCGP +++EH FF++I+W+ L +++ PFKP + + NF + FT P +P
Sbjct: 581 LGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTP 639
Query: 362 ---AALPQSSEKLFQGYSFVAPSIL 383
+ + F+G+S+V P +
Sbjct: 640 PDQLVIANIDQSDFEGFSYVNPQFV 664
Score = 59.3 bits (142), Expect = 9e-09
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 6/121 (4%)
Query: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEGHPNIVKLH 485
LG+GSF K + + +A+KI+ K + T E L L + P + +LH
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F + VME +NGG+L I++ F E +A + ++ + +H G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 546 K 546
K
Sbjct: 465 K 465
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 255 bits (651), Expect = 8e-68
Identities = 147/344 (42%), Positives = 200/344 (58%), Gaps = 23/344 (6%)
Query: 48 NFELLKVLGTGAYGKVFLV-RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F+ LKV+G G++GKV L RK+ G K YA+KVL+K ++ + K +H ER VL
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKVLQKKIVLNR-KEQKHIMAERNVLL 215
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LHY+FQT KL+ +LD++NGGELF HL + F EH + Y EI AL
Sbjct: 216 KNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALG 275
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH + I+YRD+K ENILLDS GHVVLTDFGL KE +A ++ +FCGT EY+AP+++R
Sbjct: 276 YLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA-ISDTTTTFCGTPEYLAPEVIR 334
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D VDWW LG ++YE+L G PF AE+ IL +S A
Sbjct: 335 --KQPYDNTVDWWCLGAVLYEMLYGLPPFYC----RDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+++ LL KD + RLG D EI+ H FF+ ++W DL KK+P PF P + D+
Sbjct: 389 WSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 347 NFAEEFTEMDPTYSPA---------ALPQSSEKLFQGYSFVAPS 381
NF FTE YS A ++ F G+S+ PS
Sbjct: 448 NFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
Score = 74.7 bits (182), Expect = 2e-13
Identities = 43/126 (34%), Positives = 71/126 (56%), Gaps = 8/126 (6%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANT--QKEITA-----LKLCEGHPNIV 482
K +G+GSF K + +AVK++ K++ N QK I A LK + HP +V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK-HPFLV 224
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+
Sbjct: 225 GLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVY 284
Query: 543 RDLKPE 548
RDLKPE
Sbjct: 285 RDLKPE 290
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 255 bits (651), Expect = 8e-68
Identities = 147/344 (42%), Positives = 200/344 (58%), Gaps = 23/344 (6%)
Query: 48 NFELLKVLGTGAYGKVFLV-RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F+ LKV+G G++GKV L RK+ G K YA+KVL+K ++ + K +H ER VL
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKVLQKKIVLNR-KEQKHIMAERNVLL 215
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LHY+FQT KL+ +LD++NGGELF HL + F EH + Y EI AL
Sbjct: 216 KNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALG 275
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH + I+YRD+K ENILLDS GHVVLTDFGL KE +A ++ +FCGT EY+AP+++R
Sbjct: 276 YLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA-ISDTTTTFCGTPEYLAPEVIR 334
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D VDWW LG ++YE+L G PF AE+ IL +S A
Sbjct: 335 --KQPYDNTVDWWCLGAVLYEMLYGLPPFYC----RDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+++ LL KD + RLG D EI+ H FF+ ++W DL KK+P PF P + D+
Sbjct: 389 WSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 347 NFAEEFTEMDPTYSPA---------ALPQSSEKLFQGYSFVAPS 381
NF FTE YS A ++ F G+S+ PS
Sbjct: 448 NFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
Score = 74.7 bits (182), Expect = 2e-13
Identities = 43/126 (34%), Positives = 71/126 (56%), Gaps = 8/126 (6%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANT--QKEITA-----LKLCEGHPNIV 482
K +G+GSF K + +AVK++ K++ N QK I A LK + HP +V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK-HPFLV 224
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+
Sbjct: 225 GLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVY 284
Query: 543 RDLKPE 548
RDLKPE
Sbjct: 285 RDLKPE 290
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 254 bits (649), Expect = 1e-67
Identities = 149/347 (42%), Positives = 201/347 (57%), Gaps = 23/347 (6%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKL-YAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F LKV+G G++GKV L R H ++ YA+KVL+K I++K K +H +ER VL
Sbjct: 97 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 151
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LH++FQT KL+ +LDYINGGELF HL + F E + Y EI AL
Sbjct: 152 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 211
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH L I+YRD+K ENILLDS GH+VLTDFGL KE + + +FCGT EY+AP+++
Sbjct: 212 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 270
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D+ VDWW LG ++YE+L G PF + AE+ IL ++ A
Sbjct: 271 --KQPYDRTVDWWCLGAVLYEMLYGLPPF----YSRNTAEMYDNILNKPLQLKPNITNSA 324
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+ L++ LL KD KRLG D EIK H+FF INWDDL KK+ PF P + D+
Sbjct: 325 RHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383
Query: 347 NFAEEFTEMDPTYSPAALPQS---------SEKLFQGYSFVAPSILF 384
+F EFTE S P S + + F G+S+ P+ F
Sbjct: 384 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 430
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/125 (32%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K +G+GSF HK +AVK++ K+ E + E L HP +V
Sbjct: 102 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 161
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+R
Sbjct: 162 LHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYR 221
Query: 544 DLKPE 548
DLKPE
Sbjct: 222 DLKPE 226
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 254 bits (649), Expect = 1e-67
Identities = 149/347 (42%), Positives = 201/347 (57%), Gaps = 23/347 (6%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKL-YAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F LKV+G G++GKV L R H ++ YA+KVL+K I++K K +H +ER VL
Sbjct: 111 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 165
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LH++FQT KL+ +LDYINGGELF HL + F E + Y EI AL
Sbjct: 166 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 225
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH L I+YRD+K ENILLDS GH+VLTDFGL KE + + +FCGT EY+AP+++
Sbjct: 226 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 284
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D+ VDWW LG ++YE+L G PF + AE+ IL ++ A
Sbjct: 285 --KQPYDRTVDWWCLGAVLYEMLYGLPPF----YSRNTAEMYDNILNKPLQLKPNITNSA 338
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+ L++ LL KD KRLG D EIK H+FF INWDDL KK+ PF P + D+
Sbjct: 339 RHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 397
Query: 347 NFAEEFTEMDPTYSPAALPQS---------SEKLFQGYSFVAPSILF 384
+F EFTE S P S + + F G+S+ P+ F
Sbjct: 398 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 444
Score = 73.9 bits (180), Expect = 3e-13
Identities = 40/125 (32%), Positives = 66/125 (52%), Gaps = 6/125 (4%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K +G+GSF HK +AVK++ K+ E + E L HP +V
Sbjct: 116 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 175
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+R
Sbjct: 176 LHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYR 235
Query: 544 DLKPE 548
DLKPE
Sbjct: 236 DLKPE 240
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,584,231
Number of Sequences: 37866
Number of extensions: 915841
Number of successful extensions: 7049
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 666
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 3539
Number of HSP's gapped (non-prelim): 1651
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.