Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 32528295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform
a [Homo sapiens]
(802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 1613 0.0
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 1099 0.0
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 1000 0.0
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 983 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 569 e-162
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 566 e-161
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 560 e-159
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 558 e-159
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 558 e-159
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 542 e-154
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 353 3e-97
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 344 2e-94
gi|4502023 AKT2 kinase [Homo sapiens] 287 3e-77
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 285 9e-77
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 284 3e-76
gi|133908623 protein kinase C, iota [Homo sapiens] 268 1e-71
gi|62241015 AKT1 kinase [Homo sapiens] 267 3e-71
gi|62241013 AKT1 kinase [Homo sapiens] 267 3e-71
gi|62241011 AKT1 kinase [Homo sapiens] 267 3e-71
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 263 5e-70
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 263 5e-70
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 263 5e-70
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 260 4e-69
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 260 4e-69
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 258 1e-68
gi|4506067 protein kinase C, alpha [Homo sapiens] 256 6e-68
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 255 1e-67
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 255 1e-67
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 254 2e-67
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 254 2e-67
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 1613 bits (4177), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
Sbjct: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
Query: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
Sbjct: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
Query: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
Sbjct: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
Query: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
Sbjct: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
Query: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
Sbjct: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
Query: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
Sbjct: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
Query: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
Sbjct: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
Query: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
Sbjct: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
Query: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
Sbjct: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
Query: 541 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 600
VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD
Sbjct: 541 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 600
Query: 601 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660
ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA
Sbjct: 601 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660
Query: 661 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH 720
KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH
Sbjct: 661 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH 720
Query: 721 AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL 780
AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL
Sbjct: 721 AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTL 780
Query: 781 QPSNPADSNNPETLFQFSDSVA 802
QPSNPADSNNPETLFQFSDSVA
Sbjct: 781 QPSNPADSNNPETLFQFSDSVA 802
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 1099 bits (2843), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY
Sbjct: 1 MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAY 60
Query: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA
Sbjct: 61 GKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYA 120
Query: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL
Sbjct: 121 FQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKL 180
Query: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS
Sbjct: 181 ENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWS 240
Query: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK
Sbjct: 241 LGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKK 300
Query: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS
Sbjct: 301 RLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYS 360
Query: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY
Sbjct: 361 PAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFY 420
Query: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN
Sbjct: 421 QHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPN 480
Query: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV
Sbjct: 481 IVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 540
Query: 541 VHRDLKPE 548
VHRDLKPE
Sbjct: 541 VHRDLKPE 548
Score = 129 bits (325), Expect = 8e-30
Identities = 80/260 (30%), Positives = 140/260 (53%), Gaps = 23/260 (8%)
Query: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHP 479
K LG G++ + RK + + +A+K++ K + +T+ E L+ P
Sbjct: 53 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112
Query: 480 NIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 539
+V LH F + L+++ +NGGELF + +++ F+E E + ++V A+ H+H +G
Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172
Query: 540 VVHRDLKPENLLFTDENDNLEIKIIDFGFAR-LKPPDNQPLKTPCFTLHYAAPELL--NQ 596
+++RD+K EN+L + N + + DFG ++ + + + C T+ Y AP+++
Sbjct: 173 IIYRDIKLENILL---DSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGD 229
Query: 597 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV 656
+G+D++ D WSLGV++Y +L+G PF S EI ++I K + + E +
Sbjct: 230 SGHDKAVDWWSLGVLMYELLTGASPFTVDGEK---NSQAEISRRILKSEPPYPQE----M 282
Query: 657 SQEAKDLIQGLLTVDPNKRL 676
S AKDLIQ LL DP KRL
Sbjct: 283 SALAKDLIQRLLMKDPKKRL 302
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 1000 bits (2586), Expect = 0.0
Identities = 497/773 (64%), Positives = 610/773 (78%), Gaps = 6/773 (0%)
Query: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
Query: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
Query: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
Query: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
FVAPSILF N AV+ D L+ +RPG VARSAMM+DSPF+Q Y+LDL++ LG+G
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
Query: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
Query: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTD 554
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPEN+L+ D
Sbjct: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540
Query: 555 ENDNLEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILY 613
+ +KIIDFGFARL+P P++TPCFTL YAAPELL Q GYDESCDLWSLGVILY
Sbjct: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600
Query: 614 TMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPN 673
MLSGQVPFQ + A EIM KI++G FS +GEAW+ VS+EAK+L++GLLTVDP
Sbjct: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
Query: 674 KRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQ 733
KRLK+ GLR + WLQDGS SS PL TPD+L SSG AV + + ATF AFN+ KREGF L+
Sbjct: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720
Query: 734 NVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPA 786
+V+ APLAKRRK K S +T +R S ++ + K P + P P+
Sbjct: 721 SVENAPLAKRRKQKLRS-ATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 983 bits (2542), Expect = 0.0
Identities = 493/773 (63%), Positives = 604/773 (78%), Gaps = 12/773 (1%)
Query: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
Query: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
Query: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
Query: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
FVAPSILF N AV+ D L+ +RPG VARSAMM Q Y+LDL++ LG+G
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
Query: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
Query: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTD 554
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPEN+L+ D
Sbjct: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 534
Query: 555 ENDNLEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILY 613
+ +KIIDFGFARL+P P++TPCFTL YAAPELL Q GYDESCDLWSLGVILY
Sbjct: 535 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
Query: 614 TMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPN 673
MLSGQVPFQ + A EIM KI++G FS +GEAW+ VS+EAK+L++GLLTVDP
Sbjct: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
Query: 674 KRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQ 733
KRLK+ GLR + WLQDGS SS PL TPD+L SSG AV + + ATF AFN+ KREGF L+
Sbjct: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
Query: 734 NVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPA 786
+V+ APLAKRRK K S +T +R S ++ + K P + P P+
Sbjct: 715 SVENAPLAKRRKQKLRS-ATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 569 bits (1467), Expect = e-162
Identities = 316/752 (42%), Positives = 455/752 (60%), Gaps = 40/752 (5%)
Query: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
E G +SG AG +G + +++ H ++ + EK +FELLKVLG G++GK
Sbjct: 21 ENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGK 75
Query: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQ 122
VFLVRK++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQ
Sbjct: 76 VFLVRKVTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQ 132
Query: 123 TETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 182
TE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K EN
Sbjct: 133 TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPEN 192
Query: 183 ILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLG 242
ILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS G
Sbjct: 193 ILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYG 249
Query: 243 VLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRL 302
VLM+E+LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RL
Sbjct: 250 VLMFEMLTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRL 305
Query: 303 GCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPA 362
G GP A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP
Sbjct: 306 GSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPG 365
Query: 363 ALPQS-SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQ 421
P + + +LF+G+SFVA ++ H V++ N+ S
Sbjct: 366 IPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS---------- 415
Query: 422 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNI 481
D + + +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI
Sbjct: 416 --DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNI 472
Query: 482 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 541
+ L +V+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVV
Sbjct: 473 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 532
Query: 542 HRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD 600
HRDLKP N+L+ DE+ N E ++I DFGFA+ +N L TPC+T ++ APE+L + GYD
Sbjct: 533 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD 592
Query: 601 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 660
E CD+WSLG++LYTML+G PF + + EI+ +I G F+ G W VS+ A
Sbjct: 593 EGCDIWSLGILLYTMLAGYTPFANGPSD----TPEEILTRIGSGKFTLSGGNWNTVSETA 648
Query: 661 KDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFH 720
KDL+ +L VDP++RL + + W+ +L + L D+ GA + AT+
Sbjct: 649 KDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGA-----MAATYS 703
Query: 721 AFNKYKREGFCLQNVDKAPLAKRRKMKKTSTS 752
A N K L+ ++ + LA+RR K ST+
Sbjct: 704 ALNSSKPTP-QLKPIESSILAQRRVRKLPSTT 734
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 566 bits (1459), Expect = e-161
Identities = 313/746 (41%), Positives = 452/746 (60%), Gaps = 40/746 (5%)
Query: 9 GGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRK 68
G +G D +G + +++ H ++ + EK +FELLKVLG G++GKVFLVRK
Sbjct: 36 GPGSGPQRDSDEGVLKEISITHHVKAGS-----EKADPSHFELLKVLGQGSFGKVFLVRK 90
Query: 69 ISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLH 128
++ D+G LYAMKVLKKAT+ K + T+ ER +L + PF+V LHYAFQTE KL+
Sbjct: 91 VTRPDSGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNH-PFVVKLHYAFQTEGKLY 147
Query: 129 LILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN 188
LILD++ GG+LFT LS+ FTE +V+ Y+ E+ L L+HLH LGIIYRD+K ENILLD
Sbjct: 148 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE 207
Query: 189 GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYEL 248
GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH + DWWS GVLM+E+
Sbjct: 208 GHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV--NRQGHSHSADWWSYGVLMFEM 264
Query: 249 LTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRD 308
LTG+ PF + + E ILK++ PQ +S A+ L++ L ++P RLG GP
Sbjct: 265 LTGSLPF----QGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDG 320
Query: 309 ADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQS- 367
A+EIK H+F+ I+W+ L +++ PFKP + D F EFT P SP P +
Sbjct: 321 AEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAG 380
Query: 368 SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDL 427
+ +LF+G+SFVA ++ H V++ N+ S D +
Sbjct: 381 AHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLVFS------------DGYV 428
Query: 428 KDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEV 487
+ +G GS+S C++CVHK +N +AVK+I K + + +EI L HPNI+ L +V
Sbjct: 429 VKETIGVGSYSECKRCVHKATNMEYAVKVIDK-SKRDPSEEIEILLRYGQHPNIITLKDV 487
Query: 488 FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 547
+ D H +LV EL+ GGEL ++I ++K FSE EAS+++ + V ++H GVVHRDLKP
Sbjct: 488 YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 547
Query: 548 ENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLW 606
N+L+ DE+ N E ++I DFGFA+ +N L TPC+T ++ APE+L + GYDE CD+W
Sbjct: 548 SNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIW 607
Query: 607 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 666
SLG++LYTML+G PF + + EI+ +I G F+ G W VS+ AKDL+
Sbjct: 608 SLGILLYTMLAGYTPFANGPSD----TPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 663
Query: 667 LLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYK 726
+L VDP++RL + + W+ +L + L D+ GA + AT+ A N K
Sbjct: 664 MLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGA-----MAATYSALNSSK 718
Query: 727 REGFCLQNVDKAPLAKRRKMKKTSTS 752
L+ ++ + LA+RR K ST+
Sbjct: 719 PTP-QLKPIESSILAQRRVRKLPSTT 743
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 560 bits (1442), Expect = e-159
Identities = 321/761 (42%), Positives = 455/761 (59%), Gaps = 54/761 (7%)
Query: 11 AAGTSADGGDGGEQLL------------TVKHELRTANLTGHA----EKVGIENFELLKV 54
A + +D + G+Q++ T + ++ +T H EK FELLKV
Sbjct: 14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKV 73
Query: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
LG G++GKVFLV+KISG D +LYAMKVLKKAT+ K + T+ ER +L + PF+
Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNH-PFI 130
Query: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGII 174
V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ LAL+HLH LGII
Sbjct: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190
Query: 175 YRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK 234
YRD+K ENILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH +
Sbjct: 191 YRDLKPENILLDEEGHIKLTDFGLSKESI-DHEKKAYSFCGTVEYMAPEVV--NRRGHTQ 247
Query: 235 AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLL 294
+ DWWS GVLM+E+LTG PF + + E ILK++ PQ +S A+ L++ L
Sbjct: 248 SADWWSFGVLMFEMLTGTLPF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
Query: 295 MKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTE 354
++P RLG GP +EIK H FF I+W+ L +++ PFKP D F EFT
Sbjct: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTA 363
Query: 355 MDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAM 413
P SP P ++ +LF+G+SFVA I ++ GV ++ +
Sbjct: 364 KTPKDSPGIPPSANAHQLFRGFSFVA-----------ITSDDESQAMQTVGVHSIVQQLH 412
Query: 414 MKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK 473
F Y++ + +G GS+S+C++C+HK +N FAVKII K T+ EI L
Sbjct: 413 RNSIQFTDGYEV---KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILL 468
Query: 474 LCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVS 533
HPNI+ L +V+ D + ++V EL+ GGEL ++I ++K FSE EAS ++ + V
Sbjct: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
Query: 534 HMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE 592
++H GVVHRDLKP N+L+ DE+ N E I+I DFGFA+ +N L TPC+T ++ APE
Sbjct: 529 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPE 588
Query: 593 LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEA 652
+L + GYD +CD+WSLGV+LYTML+G PF + + EI+ +I G FS G
Sbjct: 589 VLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD----TPEEILARIGSGKFSLSGGY 644
Query: 653 WKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVH 712
W +VS AKDL+ +L VDP++RL + + + W+ QL L D + V
Sbjct: 645 WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVK 700
Query: 713 TCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TSTS 752
+ AT+ A N + + L+ V ++ LA+RR +KK TST+
Sbjct: 701 GAMAATYSALN--RNQSPVLEPVGRSTLAQRRGIKKITSTA 739
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 558 bits (1438), Expect = e-159
Identities = 312/713 (43%), Positives = 446/713 (62%), Gaps = 36/713 (5%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 60 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 117
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 118 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 176
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 177 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 235
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 236 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 289
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 290 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 349
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 350 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 409
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 410 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 456
Query: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 457 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 516
Query: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPL 579
AS ++ + + ++H GVVHRDLKP N+L+ DE+ + E I++ DFGFA+ N L
Sbjct: 517 ASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLL 576
Query: 580 KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 639
TPC+T ++ APE+L + GYD +CD+WSLG++LYTML+G PF + + EI+
Sbjct: 577 MTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDD----TPEEILA 632
Query: 640 KIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 699
+I G ++ G W ++S AKD++ +L VDP++RL + + W+ + LS N L
Sbjct: 633 RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLS 692
Query: 700 TPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
D+ GA + AT+ A N+ + L+ V + LA+RR MK+ TST
Sbjct: 693 RQDVHLVKGA-----MAATYFALNR-TPQAPRLEPVLSSNLAQRRGMKRLTST 739
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 558 bits (1438), Expect = e-159
Identities = 312/713 (43%), Positives = 446/713 (62%), Gaps = 36/713 (5%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G+YGKVFLVRK+ G D G+LYAMKVLKKAT+ K + ++ E
Sbjct: 52 EKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATL--KVRDRVRSKME 109
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+
Sbjct: 110 RDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 168
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH LGIIYRD+K ENILLD GH+ +TDFGLSKE + D +RAYSFCGTIEYMA
Sbjct: 169 ALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMA 227
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG+ PF K + A ILK++ PQ
Sbjct: 228 PEVV--NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA----LILKAKLGMPQF 281
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+S A+ L++ L ++P RLG G +EIK H FF I+W+ L K++ PFKP +
Sbjct: 282 LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGR 341
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGV 400
D +F EFT PT SP P ++ LF+G+SFVA S++ + + + + H V
Sbjct: 342 PEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIV 401
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
++ N+ F Y++ + +G GS+S+C++CVHK ++ +AVKII K
Sbjct: 402 QQLHGNNI---------HFTDGYEI---KEDIGVGSYSVCKRCVHKATDTEYAVKIIDK- 448
Query: 461 MEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETE 520
+ + +EI L HPNI+ L +V+ D +LVMEL+ GGEL +RI ++++FSE E
Sbjct: 449 SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE 508
Query: 521 ASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPL 579
AS ++ + + ++H GVVHRDLKP N+L+ DE+ + E I++ DFGFA+ N L
Sbjct: 509 ASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLL 568
Query: 580 KTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 639
TPC+T ++ APE+L + GYD +CD+WSLG++LYTML+G PF + + EI+
Sbjct: 569 MTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDD----TPEEILA 624
Query: 640 KIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 699
+I G ++ G W ++S AKD++ +L VDP++RL + + W+ + LS N L
Sbjct: 625 RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLS 684
Query: 700 TPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
D+ GA + AT+ A N+ + L+ V + LA+RR MK+ TST
Sbjct: 685 RQDVHLVKGA-----MAATYFALNR-TPQAPRLEPVLSSNLAQRRGMKRLTST 731
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 542 bits (1396), Expect = e-154
Identities = 319/714 (44%), Positives = 439/714 (61%), Gaps = 40/714 (5%)
Query: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
EK FELLKVLG G++GKVFLVRK +G D G+LYAMKVLKKA++ K + T+ E
Sbjct: 66 EKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKME 123
Query: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
R +L + PF+V LHYAFQTE KL+LILD++ GG++FT LS+ FTE +V+ Y+ E+
Sbjct: 124 RDILVEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 182
Query: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
LAL+HLH+LGI+YRD+K ENILLD GH+ LTDFGLSKE V D+ ++AYSFCGT+EYMA
Sbjct: 183 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV-DQEKKAYSFCGTVEYMA 241
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
P++V GH ++ DWWS GVLM+E+LTG PF + + E ILK++ PQ
Sbjct: 242 PEVV--NRRGHSQSADWWSYGVLMFEMLTGTLPF----QGKDRNETMNMILKAKLGMPQF 295
Query: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
+SA A+ L++ L ++P RL G +EIK HLFF I+WD L ++V PFKP
Sbjct: 296 LSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Query: 342 ELDVSNFAEEFTEMDPTYSPAALPQS--SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMG 399
D F EFT P SP LP S + +LF+G+SFVA SI + I
Sbjct: 354 PDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPI 412
Query: 400 VERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISK 459
V+ G N A+ F + Y+L + +G GS+S+C++C+H +N FAVKII K
Sbjct: 413 VQING--NAAQ--------FGEVYEL---KEDIGVGSYSVCKRCIHATTNMEFAVKIIDK 459
Query: 460 RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSET 519
+ + +EI L HPNI+ L +VF D + +LV +L+ GGEL +RI K+K FSE
Sbjct: 460 -SKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSER 518
Query: 520 EASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQP 578
EAS I+ + V ++H GVVHRDLKP N+L+ DE+ + + I+I DFGFA+ +N
Sbjct: 519 EASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGL 578
Query: 579 LKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM 638
L TPC+T ++ APE+L Q GYD +CD+WSLGV+ YTML+G PF + + EI+
Sbjct: 579 LLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPND----TPEEIL 634
Query: 639 KKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPL 698
+I G FS G W N+S AKDL+ +L +DP++R + + W+ QL ++
Sbjct: 635 LRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQP 694
Query: 699 MTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
D+ V + AT+ A +K L+ V + LA+RR MKK TST
Sbjct: 695 KRNDV----SHVVKGAMVATYSALT-HKTFQPVLEPVAASSLAQRRSMKKRTST 743
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 353 bits (907), Expect = 3e-97
Identities = 190/387 (49%), Positives = 260/387 (67%), Gaps = 14/387 (3%)
Query: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKH----ELRTANLTGHAEKVGIENFELLKVLGTG 58
E+ GG S D G G L ++H E+ ++ EK+ E FELL+VLG G
Sbjct: 41 EDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKG 100
Query: 59 AYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLH 118
YGKVF VRK++G +TGK++AMKVLKKA IV+ AK T HT+ ER +LE ++ PF+V L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLI 159
Query: 119 YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDI 178
YAFQT KL+LIL+Y++GGELF L + F E Y+ EI +AL HLH+ GIIYRD+
Sbjct: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
Query: 179 KLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDW 238
K ENI+L+ GHV LTDFGL KE + D T ++FCGTIEYMAP+I+ SGH++AVDW
Sbjct: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTV-THTFCGTIEYMAPEILM--RSGHNRAVDW 276
Query: 239 WSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDP 298
WSLG LMY++LTGA PFT + K + +ILK + P ++ A+DL+++LL ++
Sbjct: 277 WSLGALMYDMLTGAPPFTGENRKKT----IDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
Query: 299 KKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPT 358
RLG GP DA E++ H FF+ INW++L A+KV PFKP+++ E DVS F +FT P
Sbjct: 333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPV 392
Query: 359 YSP--AALPQSSEKLFQGYSFVAPSIL 383
SP + L +S+ ++F G+++VAPS+L
Sbjct: 393 DSPDDSTLSESANQVFLGFTYVAPSVL 419
Score = 128 bits (321), Expect = 2e-29
Identities = 79/250 (31%), Positives = 127/250 (50%), Gaps = 20/250 (8%)
Query: 433 GEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG------HPNIVKLHE 486
G G RK + + FA+K++ K M K+ K HP IV L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
Query: 487 VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK 546
F +L++E L+GGELF +++++ F E A + + ++ A+ H+H G+++RDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 547 PENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLW 606
PEN++ N +K+ DFG + D T C T+ Y APE+L ++G++ + D W
Sbjct: 221 PENIML---NHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWW 277
Query: 607 SLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQG 666
SLG ++Y ML+G PF +R T + KI K + ++QEA+DL++
Sbjct: 278 SLGALMYDMLTGAPPFTGENRKKT-------IDKILKCKLNLP----PYLTQEARDLLKK 326
Query: 667 LLTVDPNKRL 676
LL + RL
Sbjct: 327 LLKRNAASRL 336
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 344 bits (883), Expect = 2e-94
Identities = 181/355 (50%), Positives = 244/355 (68%), Gaps = 10/355 (2%)
Query: 31 ELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQ 90
EL ++ E++G FELL+VLG G YGKVF VRK+ G + GK+YAMKVL+KA IV+
Sbjct: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
Query: 91 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150
AK T HTR ER +LE ++ PF+V L YAFQT KL+LIL+ ++GGELFTHL + F
Sbjct: 109 NAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
Query: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 210
E Y+ EI LAL HLH GIIYRD+K ENI+L S GH+ LTDFGL KE + E
Sbjct: 168 EDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVT 226
Query: 211 YSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRR 270
++FCGTIEYMAP+I+ SGH++AVDWWSLG LMY++LTG+ PFT + K + +I R
Sbjct: 227 HTFCGTIEYMAPEIL--VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG 284
Query: 271 ILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKK 330
L + PPY ++ A+DL+++ L ++P +R+G GP DA +++ H FF+ +NWDDL A +
Sbjct: 285 KL-ALPPY---LTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
Query: 331 VPAPFKPVIRDELDVSNFAEEFTEMDPTYSP--AALPQSSEKLFQGYSFVAPSIL 383
V PF+P ++ E DVS F FT P SP AL +S+ + F G+++VAPS+L
Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
Score = 127 bits (318), Expect = 5e-29
Identities = 76/251 (30%), Positives = 135/251 (53%), Gaps = 22/251 (8%)
Query: 433 GEGSFSICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHPNIVKLH 485
G G RK + +A+K++ K + A+T+ E L+ + HP IV+L
Sbjct: 77 GYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELA 135
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F +L++E L+GGELF ++++ F E A + + ++ A+ H+H G+++RDL
Sbjct: 136 YAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDL 195
Query: 546 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL 605
KPEN++ + + IK+ DFG + + T C T+ Y APE+L ++G++ + D
Sbjct: 196 KPENIMLSSQG---HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDW 252
Query: 606 WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ 665
WSLG ++Y ML+G PF + +R T M KI +G + ++ +A+DL++
Sbjct: 253 WSLGALMYDMLTGSPPFTAENRKKT-------MDKIIRGKLALP----PYLTPDARDLVK 301
Query: 666 GLLTVDPNKRL 676
L +P++R+
Sbjct: 302 KFLKRNPSQRI 312
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 287 bits (734), Expect = 3e-77
Identities = 151/319 (47%), Positives = 204/319 (63%), Gaps = 12/319 (3%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
KV + +F+ LK+LG G +GKV LVR+ + TG+ YAMK+L+K I+ K + HT TE
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIAKDEVA-HTVTES 201
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L YAFQT +L +++Y NGGELF HLS+ FTE + Y EIV
Sbjct: 202 RVLQNTRH-PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260
Query: 163 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
ALE+LH ++YRDIKLEN++LD +GH+ +TDFGL KE ++D +FCGT EY+AP
Sbjct: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK-TFCGTPEYLAP 319
Query: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEM 282
+++ D G +AVDWW LGV+MYE++ G PF + IL E +P+ +
Sbjct: 320 EVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPF----YNQDHERLFELILMEEIRFPRTL 373
Query: 283 SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDE 342
S AK L+ LL KDPK+RLG GP DA E+ EH FF INW D+ KK+ PFKP + E
Sbjct: 374 SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSE 433
Query: 343 LDVSNFAEEFTEMDPTYSP 361
+D F +EFT T +P
Sbjct: 434 VDTRYFDDEFTAQSITITP 452
Score = 134 bits (338), Expect = 3e-31
Identities = 100/319 (31%), Positives = 150/319 (47%), Gaps = 25/319 (7%)
Query: 365 PQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPG-VTNVARSAMMKDSPFYQHY 423
P E+ + VA S+ K+ A DP+ + G T A+ K
Sbjct: 93 PDEREEWMRAIQMVANSL--KQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMN 150
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEG 477
D D K LG+G+F K + + +A+KI+ K + A+T E L+
Sbjct: 151 DFDYL-KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR- 208
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
HP + L F VME NGGELF + +++ F+E A + ++VSA+ ++H
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268
Query: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 597
VV+RD+K ENL+ + IKI DFG + D +KT C T Y APE+L N
Sbjct: 269 RDVVYRDIKLENLMLDKDG---HIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN 325
Query: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Y + D W LGV++Y M+ G++PF + D + + I + F + +S
Sbjct: 326 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-------RLFELILMEEIRFP----RTLS 374
Query: 658 QEAKDLIQGLLTVDPNKRL 676
EAK L+ GLL DP +RL
Sbjct: 375 PEAKSLLAGLLKKDPKQRL 393
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 285 bits (730), Expect = 9e-77
Identities = 157/347 (45%), Positives = 218/347 (62%), Gaps = 15/347 (4%)
Query: 24 QLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVL 83
Q+ + E A+ T H K + +F+ LK+LG G +GKV LVR+ + +GK YAMK+L
Sbjct: 124 QIDNIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKIL 179
Query: 84 KKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHL 143
KK I+ K + HT TE +VL++ R PFL +L Y+FQT+ +L +++Y+NGGELF HL
Sbjct: 180 KKEVIIAKDEVA-HTLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHL 237
Query: 144 SQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFV 203
S+ F+E + Y EIV AL++LH I+YRD+KLEN++LD +GH+ +TDFGL KE +
Sbjct: 238 SRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 204 ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKN 262
D +FCGT EY+AP+++ D G +AVDWW LGV+MYE++ G PF D EK
Sbjct: 298 TDAATMK-TFCGTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK- 353
Query: 263 SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKIN 322
+ IL + +P+ +S+ AK L+ LL+KDP KRLG GP DA EI H FF +N
Sbjct: 354 ----LFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVN 409
Query: 323 WDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE 369
W D+ KK+ PFKP + E D F EEFT T +P Q S+
Sbjct: 410 WQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
Score = 139 bits (350), Expect = 1e-32
Identities = 89/253 (35%), Positives = 131/253 (51%), Gaps = 21/253 (8%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K LG+G+F K S + +A+KI+ K + A+T E LK HP +
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTS 210
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
L F + VME +NGGELF + +++ FSE + ++VSA+ ++H +V+R
Sbjct: 211 LKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYR 270
Query: 544 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 603
DLK ENL+ + IKI DFG + D +KT C T Y APE+L N Y +
Sbjct: 271 DLKLENLMLDKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 604 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 663
D W LGV++Y M+ G++PF + D ++ + I D F + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEDIKFP----RTLSSDAKSL 376
Query: 664 IQGLLTVDPNKRL 676
+ GLL DPNKRL
Sbjct: 377 LSGLLIKDPNKRL 389
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 284 bits (726), Expect = 3e-76
Identities = 155/339 (45%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 24 QLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVL 83
Q+ + E A+ T H K + +F+ LK+LG G +GKV LVR+ + +GK YAMK+L
Sbjct: 124 QIDNIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKIL 179
Query: 84 KKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHL 143
KK I+ K + HT TE +VL++ R PFL +L Y+FQT+ +L +++Y+NGGELF HL
Sbjct: 180 KKEVIIAKDEVA-HTLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHL 237
Query: 144 SQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFV 203
S+ F+E + Y EIV AL++LH I+YRD+KLEN++LD +GH+ +TDFGL KE +
Sbjct: 238 SRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
Query: 204 ADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKN 262
D +FCGT EY+AP+++ D G +AVDWW LGV+MYE++ G PF D EK
Sbjct: 298 TDAATMK-TFCGTPEYLAPEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK- 353
Query: 263 SQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKIN 322
+ IL + +P+ +S+ AK L+ LL+KDP KRLG GP DA EI H FF +N
Sbjct: 354 ----LFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVN 409
Query: 323 WDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP 361
W D+ KK+ PFKP + E D F EEFT T +P
Sbjct: 410 WQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
Score = 139 bits (350), Expect = 1e-32
Identities = 89/253 (35%), Positives = 131/253 (51%), Gaps = 21/253 (8%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K LG+G+F K S + +A+KI+ K + A+T E LK HP +
Sbjct: 152 KLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTS 210
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
L F + VME +NGGELF + +++ FSE + ++VSA+ ++H +V+R
Sbjct: 211 LKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYR 270
Query: 544 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 603
DLK ENL+ + IKI DFG + D +KT C T Y APE+L N Y +
Sbjct: 271 DLKLENLMLDKDG---HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 604 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 663
D W LGV++Y M+ G++PF + D ++ + I D F + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEDIKFP----RTLSSDAKSL 376
Query: 664 IQGLLTVDPNKRL 676
+ GLL DPNKRL
Sbjct: 377 LSGLLIKDPNKRL 389
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 268 bits (685), Expect = 1e-71
Identities = 141/370 (38%), Positives = 227/370 (61%), Gaps = 16/370 (4%)
Query: 23 EQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKV 82
+Q+ K + T + +G+++F+LL+V+G G+Y KV LVR T ++YAMKV
Sbjct: 228 DQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRL---KKTDRIYAMKV 284
Query: 83 LKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTH 142
+KK +V + + +TE+ V E PFLV LH FQTE++L +++Y+NGG+L H
Sbjct: 285 VKKE-LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFH 343
Query: 143 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF 202
+ ++ + E + Y EI LAL +LH+ GIIYRD+KL+N+LLDS GH+ LTD+G+ KE
Sbjct: 344 MQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEG 403
Query: 203 VADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDG--- 259
+ + +FCGT Y+AP+I+RG D G +VDWW+LGVLM+E++ G SPF + G
Sbjct: 404 LR-PGDTTSTFCGTPNYIAPEILRGEDYGF--SVDWWALGVLMFEMMAGRSPFDIVGSSD 460
Query: 260 --EKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHL 316
++N++ + + IL+ + P+ +S A +++ L KDPK+RLGC P+ +I+ H
Sbjct: 461 NPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
Query: 317 FFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQ 373
FF+ ++WD + K+V PFKP I E + NF +FT +P + + + F+
Sbjct: 521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 580
Query: 374 GYSFVAPSIL 383
G+ ++ P ++
Sbjct: 581 GFEYINPLLM 590
Score = 114 bits (286), Expect = 3e-25
Identities = 79/287 (27%), Positives = 141/287 (49%), Gaps = 24/287 (8%)
Query: 401 ERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR 460
E N S S Q +DL + +G GS++ KK+++ +A+K++ K
Sbjct: 232 EEKEAMNTRESGKASSSLGLQDFDLL---RVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 288
Query: 461 MEAN------TQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK 514
+ + Q E + HP +V LH F + F V+E +NGG+L +++++
Sbjct: 289 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQR 348
Query: 515 HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFAR--LK 572
E A + ++ A++++H+ G+++RDLK +N+L E IK+ D+G + L+
Sbjct: 349 KLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG---HIKLTDYGMCKEGLR 405
Query: 573 PPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQ---SHDRSL 629
P D T C T +Y APE+L Y S D W+LGV+++ M++G+ PF S D
Sbjct: 406 PGDT--TSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPD 463
Query: 630 TCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL 676
T ++K + +++S +A +++ L DP +RL
Sbjct: 464 QNTEDYLFQVILEK-----QIRIPRSLSVKAASVLKSFLNKDPKERL 505
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 3e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 129 bits (325), Expect = 8e-30
Identities = 87/255 (34%), Positives = 128/255 (50%), Gaps = 24/255 (9%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 601
+RDLK ENL+ + IKI DFG + D +KT C T Y APE+L N Y
Sbjct: 272 YRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328
Query: 602 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 661
+ D W LGV++Y M+ G++PF + D ++ + I + F + + EAK
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEEIRFP----RTLGPEAK 377
Query: 662 DLIQGLLTVDPNKRL 676
L+ GLL DP +RL
Sbjct: 378 SLLSGLLKKDPKQRL 392
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 3e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 129 bits (325), Expect = 8e-30
Identities = 87/255 (34%), Positives = 128/255 (50%), Gaps = 24/255 (9%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 601
+RDLK ENL+ + IKI DFG + D +KT C T Y APE+L N Y
Sbjct: 272 YRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328
Query: 602 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 661
+ D W LGV++Y M+ G++PF + D ++ + I + F + + EAK
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEEIRFP----RTLGPEAK 377
Query: 662 DLIQGLLTVDPNKRL 676
L+ GLL DP +RL
Sbjct: 378 SLLSGLLKKDPKQRL 392
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 267 bits (683), Expect = 3e-71
Identities = 150/329 (45%), Positives = 203/329 (61%), Gaps = 15/329 (4%)
Query: 43 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 102
+V + FE LK+LG G +GKV LV++ + TG+ YAMK+LKK IV K + HT TE
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIVAKDEVA-HTLTEN 199
Query: 103 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIV 162
+VL++ R PFL L Y+FQT +L +++Y NGGELF HLS+ F+E + Y EIV
Sbjct: 200 RVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 163 LALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
AL++LH + ++YRD+KLEN++LD +GH+ +TDFGL KE + D +FCGT EY+A
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK-TFCGTPEYLA 317
Query: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEISRRILKSEPPYPQ 280
P+++ D G +AVDWW LGV+MYE++ G PF D EK + IL E +P+
Sbjct: 318 PEVLEDNDYG--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-----LFELILMEEIRFPR 370
Query: 281 EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR 340
+ AK L+ LL KDPK+RLG G DA EI +H FF I W + KK+ PFKP +
Sbjct: 371 TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 430
Query: 341 DELDVSNFAEEFTEMDPTYSPAALPQSSE 369
E D F EEFT T +P S E
Sbjct: 431 SETDTRYFDEEFTAQMITITPPDQDDSME 459
Score = 129 bits (325), Expect = 8e-30
Identities = 87/255 (34%), Positives = 128/255 (50%), Gaps = 24/255 (9%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEG-------HPNIV 482
K LG+G+F K + + +A+KI+ K E K+ A L E HP +
Sbjct: 154 KLLGKGTFGKVILVKEKATGRYYAMKILKK--EVIVAKDEVAHTLTENRVLQNSRHPFLT 211
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVV 541
L F VME NGGELF + +++ FSE A + ++VSA+ ++H + VV
Sbjct: 212 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 271
Query: 542 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 601
+RDLK ENL+ + IKI DFG + D +KT C T Y APE+L N Y
Sbjct: 272 YRDLKLENLMLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 328
Query: 602 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 661
+ D W LGV++Y M+ G++PF + D ++ + I + F + + EAK
Sbjct: 329 AVDWWGLGVVMYEMMCGRLPFYNQDHE-------KLFELILMEEIRFP----RTLGPEAK 377
Query: 662 DLIQGLLTVDPNKRL 676
L+ GLL DP +RL
Sbjct: 378 SLLSGLLKKDPKQRL 392
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 263 bits (672), Expect = 5e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 116
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 235
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 236 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 293
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 294 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 353
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 354 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 110 bits (274), Expect = 7e-24
Identities = 70/259 (27%), Positives = 130/259 (50%), Gaps = 14/259 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 68 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 126
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 127 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 186
Query: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 597
G+++RDLK +N+L + IK+ D+G + T C T +Y APE+L
Sbjct: 187 RGIIYRDLKLDNVLLDADG---HIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
Query: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Y S D W+LGV+++ M++G+ PF + + + + I + + +S
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLS 299
Query: 658 QEAKDLIQGLLTVDPNKRL 676
+A +++G L DP +RL
Sbjct: 300 VKASHVLKGFLNKDPKERL 318
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 263 bits (672), Expect = 5e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 116
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 235
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 236 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 293
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 294 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 353
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 354 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 110 bits (274), Expect = 7e-24
Identities = 70/259 (27%), Positives = 130/259 (50%), Gaps = 14/259 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 68 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 126
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 127 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 186
Query: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 597
G+++RDLK +N+L + IK+ D+G + T C T +Y APE+L
Sbjct: 187 RGIIYRDLKLDNVLLDADG---HIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
Query: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Y S D W+LGV+++ M++G+ PF + + + + I + + +S
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLS 299
Query: 658 QEAKDLIQGLLTVDPNKRL 676
+A +++G L DP +RL
Sbjct: 300 VKASHVLKGFLNKDPKERL 318
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 263 bits (672), Expect = 5e-70
Identities = 137/350 (39%), Positives = 224/350 (64%), Gaps = 14/350 (4%)
Query: 41 AEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRT 100
++ +G+++F+L++V+G G+Y KV LVR + +D ++YAMKV+KK +V + + +T
Sbjct: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVR-LKKND--QIYAMKVVKKE-LVHDDEDIDWVQT 299
Query: 101 ERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 160
E+ V E +PFLV LH FQT ++L L+++Y+NGG+L H+ ++ + E + Y E
Sbjct: 300 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 359
Query: 161 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYM 220
I +AL LH+ GIIYRD+KL+N+LLD++GH+ LTD+G+ KE + + +FCGT Y+
Sbjct: 360 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYI 418
Query: 221 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKSEPP 277
AP+I+RG + G +VDWW+LGVLM+E++ G SPF T + + N++ + + IL+
Sbjct: 419 APEILRGEEYGF--SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIR 476
Query: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDA-DEIKEHLFFQKINWDDLAAKKVPAPFK 336
P+ +S A +++ L KDPK+RLGC P+ +IK H FF+ I+WD L K+ PF+
Sbjct: 477 IPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQ 536
Query: 337 PVIRDELDVSNFAEEFTEMDPTYSP---AALPQSSEKLFQGYSFVAPSIL 383
P I D+ + NF +FT +P A+ + + F+G+ ++ P +L
Sbjct: 537 PQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 586
Score = 110 bits (274), Expect = 7e-24
Identities = 70/259 (27%), Positives = 130/259 (50%), Gaps = 14/259 (5%)
Query: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEG 477
D DL + +G GS++ KK++Q +A+K++ K + + Q E +
Sbjct: 251 DFDLI-RVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 309
Query: 478 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD 537
+P +V LH F FLV+E +NGG+L +++++ E A + ++ A++ +H+
Sbjct: 310 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 369
Query: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 597
G+++RDLK +N+L + IK+ D+G + T C T +Y APE+L
Sbjct: 370 RGIIYRDLKLDNVLLDADG---HIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 426
Query: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Y S D W+LGV+++ M++G+ PF + + + + I + + +S
Sbjct: 427 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLS 482
Query: 658 QEAKDLIQGLLTVDPNKRL 676
+A +++G L DP +RL
Sbjct: 483 VKASHVLKGFLNKDPKERL 501
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 260 bits (664), Expect = 4e-69
Identities = 148/336 (44%), Positives = 199/336 (59%), Gaps = 18/336 (5%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEH 107
+F+ LKV+G G YGKV L ++ S G YA+KVL+K +I++K K H ER VL
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK-KEQSHIMAERSVLLK 89
Query: 108 IRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEH 167
+ PFLV L Y+FQT KL+ +LDY+NGGELF HL + RF E + Y E+ A+ +
Sbjct: 90 NVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGY 149
Query: 168 LHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG 227
LH L IIYRD+K ENILLD GHVVLTDFGL KE V E + +FCGT EY+AP+++R
Sbjct: 150 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE-DTTSTFCGTPEYLAPEVLR- 207
Query: 228 GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAK 287
+D+AVDWW LG ++YE+L G PF +++ IL P + A
Sbjct: 208 -KEPYDRAVDWWCLGAVLYEMLHGLPPF----YSQDVSQMYENILHQPLQIPGGRTVAAC 262
Query: 288 DLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSN 347
DL+Q LL KD ++RLG D EIK H+FF INWDDL K++ PF P + D+ +
Sbjct: 263 DLLQSLLHKDQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 348 FAEEFTEMDPTYSPAALPQS------SEKLFQGYSF 377
F EFT+ + S P + + F G+S+
Sbjct: 322 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
Score = 119 bits (297), Expect = 1e-26
Identities = 78/266 (29%), Positives = 126/266 (47%), Gaps = 21/266 (7%)
Query: 417 SPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEIT 470
+P Q D D K +G+G++ K +AVK++ K+ +++ E +
Sbjct: 27 NPNAQPTDFDFL-KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 85
Query: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVS 530
L HP +V L F + V++ +NGGELF +++++ F E A + ++ S
Sbjct: 86 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 145
Query: 531 AVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAA 590
A+ ++H + +++RDLKPEN+L + + + DFG + T C T Y A
Sbjct: 146 AIGYLHSLNIIYRDLKPENILLDCQG---HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLA 202
Query: 591 PELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEG 650
PE+L + YD + D W LG +LY ML G PF S D S + + +I G
Sbjct: 203 PEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGR----- 257
Query: 651 EAWKNVSQEAKDLIQGLLTVDPNKRL 676
+ A DL+Q LL D +RL
Sbjct: 258 ------TVAACDLLQSLLHKDQRQRL 277
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 260 bits (664), Expect = 4e-69
Identities = 148/336 (44%), Positives = 199/336 (59%), Gaps = 18/336 (5%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEH 107
+F+ LKV+G G YGKV L ++ S G YA+KVL+K +I++K K H ER VL
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK-KEQSHIMAERSVLLK 149
Query: 108 IRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEH 167
+ PFLV L Y+FQT KL+ +LDY+NGGELF HL + RF E + Y E+ A+ +
Sbjct: 150 NVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGY 209
Query: 168 LHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRG 227
LH L IIYRD+K ENILLD GHVVLTDFGL KE V E + +FCGT EY+AP+++R
Sbjct: 210 LHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE-DTTSTFCGTPEYLAPEVLR- 267
Query: 228 GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAK 287
+D+AVDWW LG ++YE+L G PF +++ IL P + A
Sbjct: 268 -KEPYDRAVDWWCLGAVLYEMLHGLPPF----YSQDVSQMYENILHQPLQIPGGRTVAAC 322
Query: 288 DLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSN 347
DL+Q LL KD ++RLG D EIK H+FF INWDDL K++ PF P + D+ +
Sbjct: 323 DLLQSLLHKDQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 348 FAEEFTEMDPTYSPAALPQS------SEKLFQGYSF 377
F EFT+ + S P + + F G+S+
Sbjct: 382 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
Score = 119 bits (297), Expect = 1e-26
Identities = 78/266 (29%), Positives = 126/266 (47%), Gaps = 21/266 (7%)
Query: 417 SPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEIT 470
+P Q D D K +G+G++ K +AVK++ K+ +++ E +
Sbjct: 87 NPNAQPTDFDFL-KVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERS 145
Query: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVS 530
L HP +V L F + V++ +NGGELF +++++ F E A + ++ S
Sbjct: 146 VLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVAS 205
Query: 531 AVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAA 590
A+ ++H + +++RDLKPEN+L + + + DFG + T C T Y A
Sbjct: 206 AIGYLHSLNIIYRDLKPENILLDCQG---HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLA 262
Query: 591 PELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEG 650
PE+L + YD + D W LG +LY ML G PF S D S + + +I G
Sbjct: 263 PEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGR----- 317
Query: 651 EAWKNVSQEAKDLIQGLLTVDPNKRL 676
+ A DL+Q LL D +RL
Sbjct: 318 ------TVAACDLLQSLLHKDQRQRL 337
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 258 bits (660), Expect = 1e-68
Identities = 139/349 (39%), Positives = 207/349 (59%), Gaps = 16/349 (4%)
Query: 39 GHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT 98
G+ +++ + +F L VLG G++GKV L + T +LYA+K+LKK ++Q E T
Sbjct: 332 GNRDRMKLTDFNFLMVLGKGSFGKVMLSER---KGTDELYAVKILKKDVVIQD-DDVECT 387
Query: 99 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYV 158
E++VL + PFL LH FQT +L+ +++Y+NGG+L H+ Q RF E Y
Sbjct: 388 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447
Query: 159 GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIE 218
EI + L L GIIYRD+KL+N++LDS GH+ + DFG+ KE + D +FCGT +
Sbjct: 448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV-TTKTFCGTPD 506
Query: 219 YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 278
Y+AP+I+ G K+VDWW+ GVL+YE+L G +PF E + E+ + I++ Y
Sbjct: 507 YIAPEIIAYQPYG--KSVDWWAFGVLLYEMLAGQAPF----EGEDEDELFQSIMEHNVAY 560
Query: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
P+ MS A + + L+ K P KRLGCGP +IKEH FF+ I+W+ L K++ P+KP
Sbjct: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620
Query: 339 IRDELDVSNFAEEFT----EMDPTYSPAALPQSSEKLFQGYSFVAPSIL 383
RD+ D SNF +EFT E+ PT + + F G+S+ P +
Sbjct: 621 ARDKRDTSNFDKEFTRQPVELTPT-DKLFIMNLDQNEFAGFSYTNPEFV 668
Score = 125 bits (315), Expect = 1e-28
Identities = 80/251 (31%), Positives = 125/251 (49%), Gaps = 20/251 (7%)
Query: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEGHPNIVKLH 485
LG+GSF K +++ +AVKI+ K + T E L L P + +LH
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F + VME +NGG+L I++ F E A + ++ + + G+++RDL
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 467
Query: 546 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL 605
K +N++ E IKI DFG + D KT C T Y APE++ Y +S D
Sbjct: 468 KLDNVMLDSEG---HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 524
Query: 606 WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ 665
W+ GV+LY ML+GQ PF+ D E+ + I + + ++ K++S+EA + +
Sbjct: 525 WAFGVLLYEMLAGQAPFEGEDED-------ELFQSIMEHNVAYP----KSMSKEAVAICK 573
Query: 666 GLLTVDPNKRL 676
GL+T P KRL
Sbjct: 574 GLMTKHPGKRL 584
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 256 bits (654), Expect = 6e-68
Identities = 140/385 (36%), Positives = 223/385 (57%), Gaps = 17/385 (4%)
Query: 2 EEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYG 61
+EEG A G G ++++ + + + + ++V + +F L VLG G++G
Sbjct: 294 DEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPS--NNLDRVKLTDFNFLMVLGKGSFG 351
Query: 62 KVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAF 121
KV L + T +LYA+K+LKK ++Q E T E++VL + + PFL LH F
Sbjct: 352 KVMLADR---KGTEELYAIKILKKDVVIQD-DDVECTMVEKRVLALLDKPPFLTQLHSCF 407
Query: 122 QTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLE 181
QT +L+ +++Y+NGG+L H+ Q +F E + Y EI + L LHK GIIYRD+KL+
Sbjct: 408 QTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLD 467
Query: 182 NILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 241
N++LDS GH+ + DFG+ KE + D +FCGT +Y+AP+I+ G K+VDWW+
Sbjct: 468 NVMLDSEGHIKIADFGMCKEHMMDGV-TTRTFCGTPDYIAPEIIAYQPYG--KSVDWWAY 524
Query: 242 GVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKR 301
GVL+YE+L G PF DGE + E+ + I++ YP+ +S A + + L+ K P KR
Sbjct: 525 GVLLYEMLAGQPPF--DGE--DEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKR 580
Query: 302 LGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSP 361
LGCGP +++EH FF++I+W+ L +++ PFKP + + NF + FT P +P
Sbjct: 581 LGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTP 639
Query: 362 ---AALPQSSEKLFQGYSFVAPSIL 383
+ + F+G+S+V P +
Sbjct: 640 PDQLVIANIDQSDFEGFSYVNPQFV 664
Score = 127 bits (319), Expect = 4e-29
Identities = 80/251 (31%), Positives = 126/251 (50%), Gaps = 20/251 (7%)
Query: 432 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN------TQKEITALKLCEGHPNIVKLH 485
LG+GSF K + + +A+KI+ K + T E L L + P + +LH
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
F + VME +NGG+L I++ F E +A + ++ + +H G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 546 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL 605
K +N++ E IKI DFG + D +T C T Y APE++ Y +S D
Sbjct: 465 KLDNVMLDSEG---HIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDW 521
Query: 606 WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ 665
W+ GV+LY ML+GQ PF D E+ + I + + S+ K++S+EA + +
Sbjct: 522 WAYGVLLYEMLAGQPPFDGEDED-------ELFQSIMEHNVSYP----KSLSKEAVSICK 570
Query: 666 GLLTVDPNKRL 676
GL+T P KRL
Sbjct: 571 GLMTKHPAKRL 581
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 255 bits (651), Expect = 1e-67
Identities = 147/344 (42%), Positives = 200/344 (58%), Gaps = 23/344 (6%)
Query: 48 NFELLKVLGTGAYGKVFLV-RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F+ LKV+G G++GKV L RK+ G K YA+KVL+K ++ + K +H ER VL
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKVLQKKIVLNR-KEQKHIMAERNVLL 215
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LHY+FQT KL+ +LD++NGGELF HL + F EH + Y EI AL
Sbjct: 216 KNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALG 275
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH + I+YRD+K ENILLDS GHVVLTDFGL KE +A ++ +FCGT EY+AP+++R
Sbjct: 276 YLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA-ISDTTTTFCGTPEYLAPEVIR 334
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D VDWW LG ++YE+L G PF AE+ IL +S A
Sbjct: 335 --KQPYDNTVDWWCLGAVLYEMLYGLPPFYC----RDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+++ LL KD + RLG D EI+ H FF+ ++W DL KK+P PF P + D+
Sbjct: 389 WSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 347 NFAEEFTEMDPTYSPA---------ALPQSSEKLFQGYSFVAPS 381
NF FTE YS A ++ F G+S+ PS
Sbjct: 448 NFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
Score = 119 bits (297), Expect = 1e-26
Identities = 80/254 (31%), Positives = 122/254 (48%), Gaps = 22/254 (8%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANT--QKEITA-----LKLCEGHPNIV 482
K +G+GSF K + +AVK++ K++ N QK I A LK + HP +V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK-HPFLV 224
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+
Sbjct: 225 GLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVY 284
Query: 543 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDES 602
RDLKPEN+L + + DFG + + T C T Y APE++ + YD +
Sbjct: 285 RDLKPENILLDSVG---HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 603 CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 662
D W LG +LY ML G PF C E+ I S VS A
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFY-------CRDVAEMYDNILHKPLSLR----PGVSLTAWS 390
Query: 663 LIQGLLTVDPNKRL 676
+++ LL D RL
Sbjct: 391 ILEELLEKDRQNRL 404
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 255 bits (651), Expect = 1e-67
Identities = 147/344 (42%), Positives = 200/344 (58%), Gaps = 23/344 (6%)
Query: 48 NFELLKVLGTGAYGKVFLV-RKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F+ LKV+G G++GKV L RK+ G K YA+KVL+K ++ + K +H ER VL
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKVLQKKIVLNR-KEQKHIMAERNVLL 215
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LHY+FQT KL+ +LD++NGGELF HL + F EH + Y EI AL
Sbjct: 216 KNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALG 275
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH + I+YRD+K ENILLDS GHVVLTDFGL KE +A ++ +FCGT EY+AP+++R
Sbjct: 276 YLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA-ISDTTTTFCGTPEYLAPEVIR 334
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D VDWW LG ++YE+L G PF AE+ IL +S A
Sbjct: 335 --KQPYDNTVDWWCLGAVLYEMLYGLPPFYC----RDVAEMYDNILHKPLSLRPGVSLTA 388
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+++ LL KD + RLG D EI+ H FF+ ++W DL KK+P PF P + D+
Sbjct: 389 WSILEELLEKDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
Query: 347 NFAEEFTEMDPTYSPA---------ALPQSSEKLFQGYSFVAPS 381
NF FTE YS A ++ F G+S+ PS
Sbjct: 448 NFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
Score = 119 bits (297), Expect = 1e-26
Identities = 80/254 (31%), Positives = 122/254 (48%), Gaps = 22/254 (8%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANT--QKEITA-----LKLCEGHPNIV 482
K +G+GSF K + +AVK++ K++ N QK I A LK + HP +V
Sbjct: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVK-HPFLV 224
Query: 483 KLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 542
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+
Sbjct: 225 GLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVY 284
Query: 543 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDES 602
RDLKPEN+L + + DFG + + T C T Y APE++ + YD +
Sbjct: 285 RDLKPENILLDSVG---HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
Query: 603 CDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 662
D W LG +LY ML G PF C E+ I S VS A
Sbjct: 342 VDWWCLGAVLYEMLYGLPPFY-------CRDVAEMYDNILHKPLSLR----PGVSLTAWS 390
Query: 663 LIQGLLTVDPNKRL 676
+++ LL D RL
Sbjct: 391 ILEELLEKDRQNRL 404
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 254 bits (649), Expect = 2e-67
Identities = 149/347 (42%), Positives = 201/347 (57%), Gaps = 23/347 (6%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKL-YAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F LKV+G G++GKV L R H ++ YA+KVL+K I++K K +H +ER VL
Sbjct: 97 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 151
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LH++FQT KL+ +LDYINGGELF HL + F E + Y EI AL
Sbjct: 152 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 211
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH L I+YRD+K ENILLDS GH+VLTDFGL KE + + +FCGT EY+AP+++
Sbjct: 212 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 270
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D+ VDWW LG ++YE+L G PF + AE+ IL ++ A
Sbjct: 271 --KQPYDRTVDWWCLGAVLYEMLYGLPPF----YSRNTAEMYDNILNKPLQLKPNITNSA 324
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+ L++ LL KD KRLG D EIK H+FF INWDDL KK+ PF P + D+
Sbjct: 325 RHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383
Query: 347 NFAEEFTEMDPTYSPAALPQS---------SEKLFQGYSFVAPSILF 384
+F EFTE S P S + + F G+S+ P+ F
Sbjct: 384 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 430
Score = 133 bits (334), Expect = 7e-31
Identities = 80/253 (31%), Positives = 126/253 (49%), Gaps = 20/253 (7%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K +G+GSF HK +AVK++ K+ E + E L HP +V
Sbjct: 102 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 161
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+R
Sbjct: 162 LHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYR 221
Query: 544 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 603
DLKPEN+L + I + DFG + N T C T Y APE+L++ YD +
Sbjct: 222 DLKPENILLDSQG---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTV 278
Query: 604 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 663
D W LG +LY ML G PF S + + + + ++K N++ A+ L
Sbjct: 279 DWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----------PNITNSARHL 327
Query: 664 IQGLLTVDPNKRL 676
++GLL D KRL
Sbjct: 328 LEGLLQKDRTKRL 340
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 254 bits (649), Expect = 2e-67
Identities = 149/347 (42%), Positives = 201/347 (57%), Gaps = 23/347 (6%)
Query: 48 NFELLKVLGTGAYGKVFLVRKISGHDTGKL-YAMKVLKKATIVQKAKTTEHTRTERQVLE 106
+F LKV+G G++GKV L R H ++ YA+KVL+K I++K K +H +ER VL
Sbjct: 111 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 165
Query: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
+ PFLV LH++FQT KL+ +LDYINGGELF HL + F E + Y EI AL
Sbjct: 166 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 225
Query: 167 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVR 226
+LH L I+YRD+K ENILLDS GH+VLTDFGL KE + + +FCGT EY+AP+++
Sbjct: 226 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 284
Query: 227 GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALA 286
+D+ VDWW LG ++YE+L G PF + AE+ IL ++ A
Sbjct: 285 --KQPYDRTVDWWCLGAVLYEMLYGLPPF----YSRNTAEMYDNILNKPLQLKPNITNSA 338
Query: 287 KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVS 346
+ L++ LL KD KRLG D EIK H+FF INWDDL KK+ PF P + D+
Sbjct: 339 RHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 397
Query: 347 NFAEEFTEMDPTYSPAALPQS---------SEKLFQGYSFVAPSILF 384
+F EFTE S P S + + F G+S+ P+ F
Sbjct: 398 HFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 444
Score = 133 bits (334), Expect = 7e-31
Identities = 80/253 (31%), Positives = 126/253 (49%), Gaps = 20/253 (7%)
Query: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 483
K +G+GSF HK +AVK++ K+ E + E L HP +V
Sbjct: 116 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 175
Query: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
LH F + V++ +NGGELF +++++ F E A + ++ SA+ ++H + +V+R
Sbjct: 176 LHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYR 235
Query: 544 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESC 603
DLKPEN+L + I + DFG + N T C T Y APE+L++ YD +
Sbjct: 236 DLKPENILLDSQG---HIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTV 292
Query: 604 DLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDL 663
D W LG +LY ML G PF S + + + + ++K N++ A+ L
Sbjct: 293 DWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----------PNITNSARHL 341
Query: 664 IQGLLTVDPNKRL 676
++GLL D KRL
Sbjct: 342 LEGLLQKDRTKRL 354
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,806,015
Number of Sequences: 37866
Number of extensions: 1391862
Number of successful extensions: 12064
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 723
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 6631
Number of HSP's gapped (non-prelim): 2330
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.