Guide to the Human Genome
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Search of human proteins with 32528291

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b
[Homo sapiens]
         (610 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo...  1241   0.0  
gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo...  1181   0.0  
gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]      836   0.0  
gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]      836   0.0  
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    69   1e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    69   2e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    64   4e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    63   9e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    61   3e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]            60   8e-09
gi|21735548 centrosomal protein 2 [Homo sapiens]                       59   1e-08
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    58   3e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    58   3e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    57   4e-08
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                57   5e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    56   8e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       56   8e-08
gi|55770834 centromere protein F [Homo sapiens]                        55   1e-07
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    55   2e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    54   3e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    54   5e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    54   5e-07
gi|9910266 kinesin family member 15 [Homo sapiens]                     53   9e-07
gi|113425145 PREDICTED: similar to Golgin subfamily A member 8-l...    52   1e-06
gi|113425137 PREDICTED: similar to Golgin subfamily A member 8-l...    52   1e-06
gi|148746195 trichohyalin [Homo sapiens]                               52   1e-06
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    52   1e-06
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    52   1e-06
gi|221219020 NYD-SP11 protein [Homo sapiens]                           52   2e-06
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap...    52   2e-06

>gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo
           sapiens]
          Length = 610

 Score = 1241 bits (3212), Expect = 0.0
 Identities = 610/610 (100%), Positives = 610/610 (100%)

Query: 1   MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL 60
           MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL
Sbjct: 1   MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL 60

Query: 61  PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT 120
           PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT
Sbjct: 61  PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT 120

Query: 121 RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY 180
           RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY
Sbjct: 121 RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY 180

Query: 181 LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS 240
           LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS
Sbjct: 181 LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS 240

Query: 241 PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV 300
           PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV
Sbjct: 241 PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV 300

Query: 301 RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS 360
           RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS
Sbjct: 301 RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS 360

Query: 361 VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS 420
           VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS
Sbjct: 361 VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS 420

Query: 421 LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA 480
           LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA
Sbjct: 421 LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA 480

Query: 481 ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI 540
           ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI
Sbjct: 481 ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI 540

Query: 541 ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK 600
           ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK
Sbjct: 541 ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK 600

Query: 601 FCGFEGLKLT 610
           FCGFEGLKLT
Sbjct: 601 FCGFEGLKLT 610


>gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo
           sapiens]
          Length = 581

 Score = 1181 bits (3054), Expect = 0.0
 Identities = 581/581 (100%), Positives = 581/581 (100%)

Query: 30  MTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPP 89
           MTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPP
Sbjct: 1   MTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPP 60

Query: 90  IPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFE 149
           IPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFE
Sbjct: 61  IPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFE 120

Query: 150 QCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARD 209
           QCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARD
Sbjct: 121 QCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARD 180

Query: 210 DLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAV 269
           DLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAV
Sbjct: 181 DLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAV 240

Query: 270 QTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGIL 329
           QTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGIL
Sbjct: 241 QTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGIL 300

Query: 330 IQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMS 389
           IQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMS
Sbjct: 301 IQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMS 360

Query: 390 DDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPN 449
           DDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPN
Sbjct: 361 DDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPN 420

Query: 450 KEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRL 509
           KEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRL
Sbjct: 421 KEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRL 480

Query: 510 CASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKIC 569
           CASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKIC
Sbjct: 481 CASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKIC 540

Query: 570 TSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT 610
           TSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT
Sbjct: 541 TSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT 581


>gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
          Length = 643

 Score =  836 bits (2159), Expect = 0.0
 Identities = 410/622 (65%), Positives = 503/622 (80%), Gaps = 29/622 (4%)

Query: 16  AADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGM 69
           AAD   ++ +D+T + + ++DPTAWATAMNNLGM P+G+ GQ ++      P FDP+L M
Sbjct: 24  AADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNM 83

Query: 70  MTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKT 129
           MTGI PI PM+PGLG+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKT
Sbjct: 84  MTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKT 143

Query: 130 VFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLG 189
           VFVGGLPEN TE+II EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLG
Sbjct: 144 VFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLG 203

Query: 190 SSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSD 249
           SSTDKKD+GRLHVDFAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+
Sbjct: 204 SSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE 263

Query: 250 HECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAA 309
           HE +++AEKLKDDSKFSEA+  LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA 
Sbjct: 264 HEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKAT 323

Query: 310 HEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369
           HE++MEEAKE FK AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+
Sbjct: 324 HEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383

Query: 370 RNIHNDELMGIRREEEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAY 428
           RN  +++LMGIRREEEMEMSDDE  +  T+    +ESAL +QA ALKEENDSLRWQLDAY
Sbjct: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443

Query: 429 RNEVELLKQEQGKVHR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKD 487
           RNEVELLKQE+ ++ R E++  K+QQL+ LQQ +QGMQQ LL +QEE   K++ELE+ K+
Sbjct: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503

Query: 488 DKLQVEKMLENLKEKESCASRLCAS-------------------NQDSEYPLEKTMNSSP 528
           ++   + +L+ L+E+      L  +                   NQD E  +EK   S  
Sbjct: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQG 561

Query: 529 IKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEM 588
           +KSE+EALL+GIISTFLHVHPFGA+IEY+ SY+ +LD+KI  +++E L+ RL   FKQE 
Sbjct: 562 LKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEF 621

Query: 589 TGVGASLEKRWKFCGFEGLKLT 610
           TGVGA+LEKRWK C FEG+K T
Sbjct: 622 TGVGATLEKRWKLCAFEGIKTT 643


>gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
          Length = 643

 Score =  836 bits (2159), Expect = 0.0
 Identities = 410/622 (65%), Positives = 503/622 (80%), Gaps = 29/622 (4%)

Query: 16  AADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGM 69
           AAD   ++ +D+T + + ++DPTAWATAMNNLGM P+G+ GQ ++      P FDP+L M
Sbjct: 24  AADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNM 83

Query: 70  MTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKT 129
           MTGI PI PM+PGLG+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKT
Sbjct: 84  MTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKT 143

Query: 130 VFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLG 189
           VFVGGLPEN TE+II EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLG
Sbjct: 144 VFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLG 203

Query: 190 SSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSD 249
           SSTDKKD+GRLHVDFAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+
Sbjct: 204 SSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE 263

Query: 250 HECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAA 309
           HE +++AEKLKDDSKFSEA+  LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA 
Sbjct: 264 HEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKAT 323

Query: 310 HEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369
           HE++MEEAKE FK AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+
Sbjct: 324 HEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383

Query: 370 RNIHNDELMGIRREEEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAY 428
           RN  +++LMGIRREEEMEMSDDE  +  T+    +ESAL +QA ALKEENDSLRWQLDAY
Sbjct: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443

Query: 429 RNEVELLKQEQGKVHR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKD 487
           RNEVELLKQE+ ++ R E++  K+QQL+ LQQ +QGMQQ LL +QEE   K++ELE+ K+
Sbjct: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503

Query: 488 DKLQVEKMLENLKEKESCASRLCAS-------------------NQDSEYPLEKTMNSSP 528
           ++   + +L+ L+E+      L  +                   NQD E  +EK   S  
Sbjct: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQG 561

Query: 529 IKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEM 588
           +KSE+EALL+GIISTFLHVHPFGA+IEY+ SY+ +LD+KI  +++E L+ RL   FKQE 
Sbjct: 562 LKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEF 621

Query: 589 TGVGASLEKRWKFCGFEGLKLT 610
           TGVGA+LEKRWK C FEG+K T
Sbjct: 622 TGVGATLEKRWKLCAFEGIKTT 643


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 63/298 (21%), Positives = 131/298 (43%), Gaps = 48/298 (16%)

Query: 214 WECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLL 273
           W+ ++RM  ++ER R +  EER+R             +     EK++++ K  E  Q   
Sbjct: 503 WDQEERMWEQDERLREK--EERMR----------EQKKMWQQEEKMREEKKTQE--QEKK 548

Query: 274 TWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFE 333
           TW +  ++           ++     +R         E+ M+E +EK ++          
Sbjct: 549 TWDQEEKMREEER------MREREKKMREEEEMMREQEEKMQEQEEKMRE---------- 592

Query: 334 QIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEI 393
                     ++K W+   K Q +   +W ++ +       D++    +EE M   ++++
Sbjct: 593 ---------QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ--EQEEMMWEQEEKM 641

Query: 394 EEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQ 453
           +E  E    +E  +  Q E ++E+ + ++ Q +  R + E ++ ++ K+  +++  + Q+
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701

Query: 454 LKLL-QQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLC 510
            K+  Q+     Q+  +  QEE ++KE   E+++D K   EKM E L E E   S  C
Sbjct: 702 EKMWGQEEKMWGQEEKMWGQEEMREKE---ERIRDQK---EKMQERLPEHEERCSEPC 753



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 68/328 (20%), Positives = 143/328 (43%), Gaps = 32/328 (9%)

Query: 214 WECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLL 273
           WE +++M  +EE+  R  +EERL            + +     +K++D     E +    
Sbjct: 320 WEQEEKMREQEEKMWR--QEERLWE---------QEKQMREQEQKMRDQE---ERMWEQD 365

Query: 274 TWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKD--MEEAKEKFKQALSGILIQ 331
             +   E   R     +   +      R    EK   E++  M E +EK ++    +  Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425

Query: 332 FEQIVAVYH-SASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMG----IRREEEM 386
            E+          K+K W+   K Q +   +W +Q E+IR+   +E+ G    + R+E+M
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIW-EQEEKIRD--QEEMWGQEKKMWRQEKM 481

Query: 387 EMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHRED 446
              +D++ E  E    +E  +  Q E + E+++ LR + +  R + ++ +QE+    RE+
Sbjct: 482 REQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM--REE 539

Query: 447 DPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCA 506
              +EQ+ K   Q  +  ++  ++ +E+  ++E E+ + +++K+Q     E  ++     
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ-----EQEEKMREQE 594

Query: 507 SRLCASNQDSEYPLEKTMNSSPIKSERE 534
            ++    +  +   EK         E+E
Sbjct: 595 EKMWEQEEKMQEQEEKMWEQEEKMWEQE 622



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 65/304 (21%), Positives = 129/304 (42%), Gaps = 31/304 (10%)

Query: 214 WECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLL 273
           W  ++R+  RE+  + R +EE++R       +   + E     ++L++  K  E  + + 
Sbjct: 258 WRQEERL--REQEGKMREQEEKMRRQEKR--LREQEKELREQEKELREQKKLREQEEQMQ 313

Query: 274 TWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFE 333
              E+ E             +       RL  +    EK M E ++K +     +  Q E
Sbjct: 314 ---EQEEKMWEQEEKMREQEEKMWRQEERLWEQ----EKQMREQEQKMRDQEERMWEQDE 366

Query: 334 QIVAVYHSASKQ-KAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDE 392
           ++        +Q K W+   K Q +      +  E  + +  +E     +EE+M+  ++ 
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEE-----RIREREKKMREEEETMREQEEKMQKQEEN 421

Query: 393 IEEMTETKETEESALVSQAEAL------KEENDSLRWQLDAYRNEVELLKQE-----QGK 441
           + E  E KE ++  L  Q E L      +E+ + +  Q +  R++ E+  QE     Q K
Sbjct: 422 MWEQEE-KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480

Query: 442 VHREDDPNKEQQLKLL--QQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENL 499
           +  ++D   EQ+ K+   +Q +   ++ + +  E  ++KE  + + K    Q EKM E  
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540

Query: 500 KEKE 503
           K +E
Sbjct: 541 KTQE 544



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 35/144 (24%), Positives = 77/144 (53%), Gaps = 13/144 (9%)

Query: 364 KQAEEIRN----IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEEND 419
           +Q EE+R     I   E    R+EE +   + ++ E  E    +E  L  Q + L+E+  
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK 297

Query: 420 SLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE 479
            LR Q    R + E +++++ K+  +++  +EQ+ K+ +Q     ++ L + +++ +++E
Sbjct: 298 ELREQ-KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ-----EERLWEQEKQMREQE 351

Query: 480 AELEKLKDDKLQVEKMLENLKEKE 503
              +K++D + ++ +  E L+EKE
Sbjct: 352 ---QKMRDQEERMWEQDERLREKE 372



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 2/121 (1%)

Query: 383 EEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKV 442
           +EEM   ++E+ E  +    +E  +  Q E L+E+   +R Q +  R + + L+ EQ K 
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR-EQEKE 291

Query: 443 HREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEK 502
            RE +    +Q KL +Q  Q MQ+   K+ E+ +K   + EK+   + ++ +  + ++E+
Sbjct: 292 LREQEKELREQKKLREQEEQ-MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350

Query: 503 E 503
           E
Sbjct: 351 E 351



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 62/324 (19%), Positives = 134/324 (41%), Gaps = 29/324 (8%)

Query: 199 RLHVDFAQARDDLYEWECKQRMLA----REERHRRRMEEERLRPPSPP-----------P 243
           RL     + R+    WE +++M      RE   + R EEE +R                 
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 426

Query: 244 VVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRL 303
              +         EKL +  K  E  + +  W +  ++  +               +R  
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKI--WEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484

Query: 304 VNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKA-WDHFTKAQRKNISVW 362
            ++    E+ M + ++K       +  Q E++        +QK  W    K + +  +  
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKT-- 542

Query: 363 CKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTET-KETEESALVSQAEALKEENDSL 421
             Q +E +    +E M  R EE M   + ++ E  E  +E EE  +  Q E ++E+ + +
Sbjct: 543 --QEQEKKTWDQEEKM--REEERMREREKKMREEEEMMREQEEK-MQEQEEKMREQEEKM 597

Query: 422 RWQLDAYRNEVE--LLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE 479
            W+ +    E E  + +QE+    +E++   ++Q +++ +  + MQ+   K+ E+ +K  
Sbjct: 598 -WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656

Query: 480 AELEKLKDDKLQVEKMLENLKEKE 503
            + EK+++ + +++   E ++E+E
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQE 680



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 52/243 (21%), Positives = 117/243 (48%), Gaps = 38/243 (15%)

Query: 293 IQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFT 352
           I++ +  +R L  +K   E  +  +++  ++   G L + + +    H +     W    
Sbjct: 87  IEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHS-----WHFAG 141

Query: 353 KAQR--KNISVWCKQA----EEIRNIHNDELMGIRRE----EEMEMSDDEIEEMTETKET 402
           + QR    +S W K+A    EE+    +   + + R     EE++  + E++E     E+
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAES 201

Query: 403 EESALVSQAEALKEENDSLRWQL----------DAYRNEVEL-------LKQEQGKVHRE 445
           E+S +    + LK + +  ++ L          + +R E EL        KQE+ K+ R+
Sbjct: 202 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE-KMWRQ 260

Query: 446 DDPNKEQQLKLLQQ--ALQGMQQHLLKVQEEYKKKEAEL---EKLKDDKLQVEKMLENLK 500
           ++  +EQ+ K+ +Q   ++  ++ L + ++E +++E EL   +KL++ + Q+++  E + 
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320

Query: 501 EKE 503
           E+E
Sbjct: 321 EQE 323


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 71/348 (20%), Positives = 152/348 (43%), Gaps = 28/348 (8%)

Query: 209 DDLYEWECK---QRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKF 265
           + + EWE K   Q    RE+  + R +EE++R       + +   E     E++  + + 
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEE 424

Query: 266 SEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQAL 325
               Q  + W E+ E  R      +   +      +R   EK   ++  +E + K  +  
Sbjct: 425 KMRRQEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 483

Query: 326 SGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS------VWCKQAEEIRN-------- 371
             I  Q E+I        +Q+   H  +  R+         +W +Q E+IR         
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW-RQEEKIREQEEIWRQK 542

Query: 372 --IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYR 429
             IH  E    ++EE+M   ++++ +  E    +E  +  Q E ++E+ + +R Q +  R
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602

Query: 430 NEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDK 489
            + E+ ++++ K+  +++   EQ+ K+ +Q  + M++   K++E+ KK   + EK+++ +
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE-EKMRRQEEKIREQEKKIREQEEKIREQE 661

Query: 490 LQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALL 537
             +++  E + E+E    ++C   +  +   EK         E+E  L
Sbjct: 662 EMMQEQEEKMWEQE---EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 706



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 63/296 (21%), Positives = 142/296 (47%), Gaps = 27/296 (9%)

Query: 215 ECKQRMLARE---ERHRRRMEEERLRPPSPPPVVHYSDHECSI--VAEKLKD-DSKFSEA 268
           E +++M  +E   E+  +R EEE++R           + E  +    EK+++ + K  E 
Sbjct: 442 ELEEKMHEQEKIREQEEKRQEEEKIREQEKR-----QEQEAKMWRQEEKIREQEEKIREQ 496

Query: 269 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGI 328
            + +  W +  +++ +         Q      R+   EK   ++++   KEK  +    I
Sbjct: 497 EEKM--WRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQEEIWRQKEKIHEQEEKI 552

Query: 329 LIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEM 388
             Q E++        ++K  D   K + +   VW +Q E+IR    ++   IR +EE   
Sbjct: 553 RKQEEKMWR-----QEEKMHDQEEKIREQEEKVW-RQEEKIR----EQEEKIREQEEKIR 602

Query: 389 SDDEIEEMTETKETE-ESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDD 447
             +E+ +  E K  E E  +  Q E ++E+ + +R Q +  R + + +++++ K+  +++
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662

Query: 448 PNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
             +EQ+ K+ +Q  +  +Q   K+QE+ +K   + EK+ + ++++ +  E ++E +
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEE-KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 42/203 (20%), Positives = 109/203 (53%), Gaps = 12/203 (5%)

Query: 305 NEKAAHEKDMEEAKEKFKQALSGILIQFEQIVA-VYHSASKQKAWDHFTKAQRKNISVWC 363
           +EK+  + +++E K K ++A   +L+  +Q+ A   H   + ++     +AQ +   +W 
Sbjct: 296 SEKSEIQLNVKELKRKLERAK--LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRW 423
           +      N   +E M  R+EE+++  +++I+E  E    +E  +  Q E ++ + + +  
Sbjct: 354 RL-----NQQQEEKMW-RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 407

Query: 424 QLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE---A 480
           + +  R + E++ +++ K+ R+++   E++ K+ +   +  +Q  ++ QEE +++E    
Sbjct: 408 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 467

Query: 481 ELEKLKDDKLQVEKMLENLKEKE 503
           E EK ++ + ++ +  E ++E+E
Sbjct: 468 EQEKRQEQEAKMWRQEEKIREQE 490



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 56/279 (20%), Positives = 123/279 (44%), Gaps = 29/279 (10%)

Query: 206 QARDDLYEWECKQRMLAR--EERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDS 263
           Q  + + E E +Q   A+   +  + R +EE++R         +   E     EK++++ 
Sbjct: 461 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM---WRQEEKIHEQEKIREEE 517

Query: 264 KFSEAVQTLLTWIERGEVNRRSANNFYSM---IQSANSHVRRLVNEKAAHEKDMEEAKEK 320
           K  E  +    W  R E   R     +     I      +R+   +    E+ M + +EK
Sbjct: 518 KRQEQEEM---W--RQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEK 572

Query: 321 FKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGI 380
            +          EQ   V+    K +  +   + Q + I    ++ EE+     +E MG 
Sbjct: 573 IR----------EQEEKVWRQEEKIREQEEKIREQEEKI----REQEEMTQ-EQEEKMG- 616

Query: 381 RREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQG 440
            +EE+M   +++++E  E    +E  +  Q + ++E+ + +R Q +  + + E + +++ 
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676

Query: 441 KVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE 479
           K+  +++  +EQ+ K+ +Q  +  +Q +   Q+E K +E
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 30/160 (18%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 344 KQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETE 403
           ++K W      Q + I  W ++ +E      ++   IR +EE     +E+    E K   
Sbjct: 360 EEKMW-----RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 414

Query: 404 ESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQG 463
           +  ++ + E      + + W+ +    E+E    EQ K+  +++  +E++    Q+  Q 
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474

Query: 464 MQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
            +  + + +E+ +++E   EK+++ + ++ +  E + E+E
Sbjct: 475 QEAKMWRQEEKIREQE---EKIREQEEKMWRQEEKIHEQE 511



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 38/181 (20%), Positives = 86/181 (47%), Gaps = 29/181 (16%)

Query: 383 EEEMEMSDDEIEEMTETKETEES-----------------------ALVSQAEALKEEND 419
           +EE++  + +++E  +  E+E+S                        L ++A+ L +E  
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336

Query: 420 SLRWQLDAYRNEVELL----KQEQGKVHREDDPNKEQQLKLLQQALQ-GMQQHLLKVQEE 474
           S+  +L A   E EL     +Q++ K+ R+++  +E + K+ +Q  +   Q+  ++ QEE
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 396

Query: 475 YKKKEAELEKLKDDKL-QVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSER 533
             +++ E+   K++K+ + E+M+   +EK      +    ++    LE+ M+      E+
Sbjct: 397 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 456

Query: 534 E 534
           E
Sbjct: 457 E 457



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 18/129 (13%)

Query: 392 EIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKE 451
           E+E+      T++       E L +E D+L   L+ YRN +             D+  KE
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTKERDAL--SLELYRNTI------------TDEELKE 282

Query: 452 QQLKLLQQALQGMQQHLLKVQEEYK--KKEAELEKLKDDKLQVEKMLENL-KEKESCASR 508
           +  K LQ+ LQ ++    ++Q   K  K++ E  KL   + Q++   ++L KE +S +++
Sbjct: 283 KNAK-LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 341

Query: 509 LCASNQDSE 517
           L A  +++E
Sbjct: 342 LQAQVEENE 350


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 89/424 (20%), Positives = 176/424 (41%), Gaps = 64/424 (15%)

Query: 149 EQCGEIIAIRKSKKNFCHIRFAEEYMVDK-ALYLSGYRIRLGSSTDKKDTGRLHVDFAQA 207
           EQ    +A +K K +    R+ EE   ++ AL L  YR  +     K+   +L     Q 
Sbjct: 166 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 216

Query: 208 RDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDH---ECSIVAEKLKDDSK 264
           +  L E E  +  L  +E  +R++E  +L  P        +DH   E   V+ KL+   +
Sbjct: 217 KLQLVESEKSEIQLNVKEL-KRKLERAKLLLPQQQLQAE-ADHLGKELQSVSAKLQAQVE 274

Query: 265 FSEAVQTL------LTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAK 318
            +E    L        W +  ++  R        IQ     +R    +    E+ M E +
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEK-----IQEQEEKIREQEEKMRRQEEMMWEKE 329

Query: 319 EKFKQA-------------LSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQ 365
           EK ++              L   + + E+I        +++      K Q +   +W +Q
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW-RQ 388

Query: 366 AEEIRNIHN------------DELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEA 413
            E+IR                +E MG  +EE+M   ++E++E  E    +E  +  Q + 
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMG-EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKK 447

Query: 414 LKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQE 473
           ++E+ + +R Q +  + + E + +++GK+  ++   +EQ+ K+ +Q          K++E
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE--------EKIRE 499

Query: 474 EYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSER 533
           + KK   + EK+++ +  +++  E + E+E    ++C   +  +   EK         E+
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWEQE---EKMCEQEEKMQEQEEKMRRQEEKMREQ 556

Query: 534 EALL 537
           E  L
Sbjct: 557 EVRL 560



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 41/192 (21%), Positives = 103/192 (53%), Gaps = 12/192 (6%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIR 370
           E+ + E +EK ++    +  Q E++        ++K W+   + Q +   +  +Q E+IR
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKM-----GEQEEKMWEQEEEMQEQEEKMR-RQEEKIR 442

Query: 371 NIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEA-LKEENDSLRWQLDAYR 429
               ++   IR +EE     +E+ +  E K  E+   + + EA ++E+ + +R Q +  R
Sbjct: 443 ----EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR 498

Query: 430 NEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDK 489
            + + +++++ K+  +++  +EQ+ K+ +Q  +  +Q   K+QE+ +K   + EK+++ +
Sbjct: 499 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE-KMQEQEEKMRRQEEKMREQE 557

Query: 490 LQVEKMLENLKE 501
           +++ +  E ++E
Sbjct: 558 VRLRQQEEKMQE 569



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/260 (19%), Positives = 110/260 (42%), Gaps = 23/260 (8%)

Query: 208 RDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSE 267
           R +   WE ++++   EE+     E+E++R             E     EK+++  K  E
Sbjct: 334 RQEEMMWEKEEKIRELEEKMH---EQEKIR----------EQEEKRQEEEKIREQEKRQE 380

Query: 268 AVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSG 327
               +    E+             M+Q     +     +    E++M+E +EK ++    
Sbjct: 381 QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440

Query: 328 ILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEME 387
           I    EQ   +     K +  +   + Q +      K  E+   +   E     +EE+M 
Sbjct: 441 IR---EQEKKIREQEEKIREQEEMMQEQEE------KMGEQEGKMCEQEAKMQEQEEKMR 491

Query: 388 MSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDD 447
             +++I E  +    +E  +  Q E ++E+ + +  Q +    + E +++++ K+ R+++
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 551

Query: 448 PNKEQQLKLLQQALQGMQQH 467
             +EQ+++L QQ  + MQ+H
Sbjct: 552 KMREQEVRLRQQE-EKMQEH 570



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 18/129 (13%)

Query: 392 EIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKE 451
           E+E+      T++       E L +E D+L   L+ YRN +             D+  KE
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDAL--SLELYRNTI------------TDEELKE 209

Query: 452 QQLKLLQQALQGMQQHLLKVQEEYK--KKEAELEKLKDDKLQVEKMLENL-KEKESCASR 508
           +  K LQ+ LQ ++    ++Q   K  K++ E  KL   + Q++   ++L KE +S +++
Sbjct: 210 KNAK-LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268

Query: 509 LCASNQDSE 517
           L A  +++E
Sbjct: 269 LQAQVEENE 277


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 69/343 (20%), Positives = 149/343 (43%), Gaps = 27/343 (7%)

Query: 206 QARDDLYEWECKQRMLAR--EERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDS 263
           Q  + + E E +Q   A+   +  + R +EE++R         +   E     EK++++ 
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM---WRQEEKIHEQEKIREEE 470

Query: 264 KFSEAVQTLLTWIERGEVN--------RRSANNFYSMIQSANSHVRRLVNEKAAHEKDME 315
           K  E  +    W +  +++        +   +     I+     V R   +    E+ + 
Sbjct: 471 KRQEQEEM---WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR 527

Query: 316 EAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHND 375
           E +EK  +    I  Q E          ++K W+   K Q +   +W +Q E+IR     
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE-EKRQEQEDKMW-RQEEKIRE---Q 582

Query: 376 ELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELL 435
           E    R+EE++   +++ +E  E    +E  +  Q E ++E+ + +R Q +  R + E+ 
Sbjct: 583 EEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMT 642

Query: 436 KQEQGKVHREDDPNKEQQLKLLQQA-LQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEK 494
           ++++ K+  +++   EQ+ K+ +Q      Q+  ++ QE  KK   + EK+++ +  +++
Sbjct: 643 QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE--KKIREQEEKIREQEEMMQE 700

Query: 495 MLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALL 537
             E + E+E    ++C   +  +   EK         E+E  L
Sbjct: 701 QEEKMWEQE---EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 43/200 (21%), Positives = 101/200 (50%), Gaps = 11/200 (5%)

Query: 306 EKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQ 365
           EK   E+  +E ++K  +    I  Q E++        ++K  +   K Q +   +W KQ
Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR-----QEEKIREQEEKRQEQEEKMW-KQ 610

Query: 366 AEEIRN----IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSL 421
            E+IR     I   E     +EE++   ++  +E  E    +E  +  Q E ++E+ +++
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670

Query: 422 RWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAE 481
             Q +  R + + +++++ K+  +++  +EQ+ K+ +Q  +  +Q   K+QE+ +K   +
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE-KMQEQEEKMRRQ 729

Query: 482 LEKLKDDKLQVEKMLENLKE 501
            EK+ + ++++ +  E ++E
Sbjct: 730 EEKMWEQEVRLRQQEEKMQE 749



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 60/305 (19%), Positives = 131/305 (42%), Gaps = 24/305 (7%)

Query: 209 DDLYEWECK---QRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKF 265
           + + EWE K   Q    RE+  + R +EE++R       + +   E     E++  + + 
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEE 363

Query: 266 SEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQAL 325
               Q  + W +  ++ R+       M+      +R L  E+  HE++    +E+ +Q  
Sbjct: 364 KMRRQEEMMWEKEEKMRRQE-----EMMWEKEEKIREL--EEKMHEQEKIREQEEKRQEE 416

Query: 326 SGILIQF---EQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIR- 381
             I  Q    EQ   ++    K +  +   + Q K +    ++  E   I  +E    + 
Sbjct: 417 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 476

Query: 382 ---REEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQE 438
              R+EE     +EI    E    +E  +  Q E +  + + +R Q +  R + E + ++
Sbjct: 477 EMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQ 536

Query: 439 QGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLEN 498
           + K+  +++  +E++    Q+ +   +    K QE+  K   + EK+++ + +V +  E 
Sbjct: 537 EEKIREQEEMWREEEKMHEQEKIWEEE----KRQEQEDKMWRQEEKIREQEEKVWRQEEK 592

Query: 499 LKEKE 503
           ++E+E
Sbjct: 593 IREQE 597



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 68/322 (21%), Positives = 143/322 (44%), Gaps = 37/322 (11%)

Query: 208 RDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSE 267
           R +   WE ++++   EE+     E+E++R             E     EK+++  K  E
Sbjct: 381 RQEEMMWEKEEKIRELEEKMH---EQEKIR----------EQEEKRQEEEKIREQEKRQE 427

Query: 268 AVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSG 327
             Q    W +  ++  +         +      +    EK   E+  +E +E ++Q    
Sbjct: 428 --QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK- 484

Query: 328 ILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEME 387
            + + E+I        K+K  +   K +++   VW +Q E+IR     E     +EE+M 
Sbjct: 485 -IHEQEEIWR-----QKEKMHEQEEKIRKQEEKVW-RQEEKIRE---QEEKIREQEEKMW 534

Query: 388 MSDDEIEEMTETKETEESA----LVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH 443
             +++I E  E    EE       + + E  +E+ D +  Q +  R + E + +++ K+ 
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594

Query: 444 REDDPNKEQQLKLLQQALQ-GMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEK 502
            +++  +EQ+ K+ +Q  +   Q+  ++ QEE K +E E EK+++ +   ++  E + E+
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE-KIREQE-EKIREQEEMTQEQEEKMGEQ 652

Query: 503 ESCASRLCASNQDSEYPLEKTM 524
           E    ++C   ++     E+TM
Sbjct: 653 E---EKMC-EQEEKMQEQEETM 670



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 51/259 (19%), Positives = 112/259 (43%), Gaps = 26/259 (10%)

Query: 214 WECKQRMLAREERHRRRME-----EERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEA 268
           W  ++++  +EE+ R + E     EE++R            HE     EK+ ++ K  E 
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE----QEKIWEEEKRQEQ 568

Query: 269 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGI 328
              +  W +  ++  +        +      +R    ++   E+ M + +EK ++    I
Sbjct: 569 EDKM--WRQEEKIREQEEK-----VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKI 621

Query: 329 LIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEM 388
             Q E+I        K +  +  T+ Q +      K  E+   +   E     +EE M  
Sbjct: 622 QEQEEKI---REQEEKIREQEEMTQEQEE------KMGEQEEKMCEQEEKMQEQEETMWR 672

Query: 389 SDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDP 448
            +++I E  +    +E  +  Q E ++E+ + +  Q +    + E +++++ K+ R+++ 
Sbjct: 673 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732

Query: 449 NKEQQLKLLQQALQGMQQH 467
             EQ+++L QQ  + MQ+H
Sbjct: 733 MWEQEVRLRQQE-EKMQEH 750



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 43/234 (18%), Positives = 112/234 (47%), Gaps = 24/234 (10%)

Query: 305 NEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCK 364
           +EK+  + +++E K K ++A   +L+  +Q+         Q   DH  K  +   SV  K
Sbjct: 235 SEKSEIQLNVKELKRKLERAK--LLLPQQQL---------QAEADHLGKELQ---SVSAK 280

Query: 365 QAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQ 424
              ++        +  ++EE+M   +++I+E  E  + +E  +  Q E ++E+ + +   
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM--- 337

Query: 425 LDAYRNEVELLKQEQGKVHREDDP--NKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL 482
               R + E++ +++ K+ R+++    KE++++  ++ +   ++ + + +E   +KE ++
Sbjct: 338 ----RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 393

Query: 483 EKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREAL 536
            +L++   + EK+ E  +EK     ++    +  E   +       I+ + E +
Sbjct: 394 RELEEKMHEQEKIREQ-EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 34/194 (17%), Positives = 92/194 (47%), Gaps = 18/194 (9%)

Query: 344 KQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE-MEMSDDEIEEMTETKET 402
           ++K W      Q + I  W ++ +E      ++   IR +EE M   ++ + E  E    
Sbjct: 299 EEKMW-----RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 403 EESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQ 462
           +E  +  + E ++ + + +  + +  R + E++ +++ K+ RE +    +Q K+ +Q  +
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEKIREQEEK 412

Query: 463 GMQQHLLKVQEEYKKKEAEL-----------EKLKDDKLQVEKMLENLKEKESCASRLCA 511
             ++  ++ QE+ +++EA++           EK+++ + ++ +  E + E+E        
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472

Query: 512 SNQDSEYPLEKTMN 525
             Q+  +  E+ ++
Sbjct: 473 QEQEEMWRQEEKIH 486



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 26/127 (20%), Positives = 64/127 (50%), Gaps = 7/127 (5%)

Query: 383 EEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVEL------LK 436
           +EE++  + +++E  +  E+E+S +    + LK + +  +  L   + + E       L+
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275

Query: 437 QEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKML 496
               K+  + + N E   +L QQ  + M +   K+QE  +K + + EK+++ + ++ +  
Sbjct: 276 SVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334

Query: 497 ENLKEKE 503
           E ++ +E
Sbjct: 335 EKMRRQE 341



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 18/129 (13%)

Query: 392 EIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKE 451
           E+E+      T++       E L +E D+L   L+ YRN +             D+  KE
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDAL--SLELYRNTI------------TDEELKE 221

Query: 452 QQLKLLQQALQGMQQHLLKVQEEYK--KKEAELEKLKDDKLQVEKMLENL-KEKESCASR 508
           +  K LQ+ LQ ++    ++Q   K  K++ E  KL   + Q++   ++L KE +S +++
Sbjct: 222 KNAK-LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280

Query: 509 LCASNQDSE 517
           L A  +++E
Sbjct: 281 LQAQVEENE 289


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 64/308 (20%), Positives = 140/308 (45%), Gaps = 29/308 (9%)

Query: 209 DDLYEWECK---QRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKF 265
           + + EWE K   Q    RE+  + R +EE++R      ++   + +     E + +  + 
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE--MMWEKEEKMRRQEEMMWEKEEK 364

Query: 266 SEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQAL 325
              ++ ++ W E+ E  R      +   +      +R   EK   ++  +E + K  +  
Sbjct: 365 MRRLEEMM-W-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 422

Query: 326 SGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMG----IR 381
             I  Q E+I        ++K W      Q + I    K  EE +    +E+      IR
Sbjct: 423 EKIREQEEKI-----REQEKKMW-----RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 472

Query: 382 REEEMEMSDDEIEEMTETKETEESA------LVSQAEALKEENDSLRWQLDAYRNEVELL 435
            +EE+    +++ E  + ++ EE        +  Q E ++E+ + +  Q +  R + E +
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532

Query: 436 KQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKM 495
           ++++ K+  +++  +EQ+ K+ +Q  +  +Q  ++ QEE K +E E EK+++ K ++ + 
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE-KIREQE-EKIREQKEKIREQ 590

Query: 496 LENLKEKE 503
            E + E+E
Sbjct: 591 EEKIWEQE 598



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 42/203 (20%), Positives = 108/203 (53%), Gaps = 12/203 (5%)

Query: 305 NEKAAHEKDMEEAKEKFKQALSGILIQFEQIVA-VYHSASKQKAWDHFTKAQRKNISVWC 363
           +EK+  + +++E K K ++A   +L+  +Q+ A   H   + ++     +AQ +   +W 
Sbjct: 235 SEKSEIQLNVKELKRKLERAK--LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRW 423
           +      N   +E M  R+EE+++  +++I+E  E    +E  +  Q E ++ + + +  
Sbjct: 293 RL-----NQQQEEKMW-RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346

Query: 424 QLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE---A 480
           + +  R + E++ +++ K+ R ++   E++ K+ +   +  +Q  ++ QEE +++E    
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406

Query: 481 ELEKLKDDKLQVEKMLENLKEKE 503
           E EK ++ + ++ +  E ++E+E
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQE 429



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 52/283 (18%), Positives = 121/283 (42%), Gaps = 20/283 (7%)

Query: 206 QARDDLYEWECKQRMLAR--EERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDS 263
           Q  + + E E +Q   A+   +  + R +EE++R         +   E     EK++++ 
Sbjct: 400 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM---WRQEEKIHEQEKIREEE 456

Query: 264 KFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQ 323
           K  E  +    W +  ++  +               +R+   +    E+ M + +EK ++
Sbjct: 457 KRQEQEEM---WRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513

Query: 324 ALSGILIQFEQI----VAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMG 379
               +  Q E+I      +     K +  +   + Q +      K  E+   +   E M 
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE------KMGEQEEKMQEQEKMR 567

Query: 380 IRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQ 439
            R+EE++   +++I E  E    +E  +  Q E ++E+ + ++ Q +    + E + +++
Sbjct: 568 -RQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 626

Query: 440 GKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL 482
            K+  +++  + Q+ K+ +Q ++  QQ   K+QE  +  EA +
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEE-KMQEHQEHLEAAI 668



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 63/305 (20%), Positives = 136/305 (44%), Gaps = 40/305 (13%)

Query: 215 ECKQRMLARE---ERHRRRMEEERLRPPSPPPVVHYSDHECSI--VAEKLKD-DSKFSEA 268
           E +++M  +E   E+  +R EEE++R           + E  +    EK+++ + K  E 
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKR-----QEQEAKMWRQEEKIREQEEKIREQ 435

Query: 269 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGI 328
            + +  W +  +++ +         Q      R+   EK   ++++   KEK  +    I
Sbjct: 436 EKKM--WRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQEEIWRQKEKMHEQ-EKI 490

Query: 329 LIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHN---DELMGIRREEE 385
             Q E++        ++K  D   K + +   +W +Q E+IR       ++   IR +EE
Sbjct: 491 RKQEEKVWR-----QEEKMHDQEEKIREQEEKMW-RQEEKIREQEEKIREQEEKIREQEE 544

Query: 386 MEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKV--- 442
           M    +E     E K  E+  +  Q E ++E+ + +R Q +  R + E + +++ K+   
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604

Query: 443 ---HREDDPNK-EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLEN 498
               +E +    EQ+ K+ +Q          K+QE+ +K   + EK+ + ++++ +  E 
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQE--------EKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656

Query: 499 LKEKE 503
           ++E +
Sbjct: 657 MQEHQ 661



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 30/160 (18%), Positives = 75/160 (46%), Gaps = 8/160 (5%)

Query: 344 KQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETE 403
           ++K W      Q + I  W ++ +E      ++   IR +EE     +E+    E K   
Sbjct: 299 EEKMW-----RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 404 ESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQG 463
           +  ++ + E      + + W+ +    E+E    EQ K+  +++  +E++    Q+  Q 
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 413

Query: 464 MQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
            +  + + +E+ +++E   EK+++ + ++ +  E + E+E
Sbjct: 414 QEAKMWRQEEKIREQE---EKIREQEKKMWRQEEKIHEQE 450



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 38/181 (20%), Positives = 86/181 (47%), Gaps = 29/181 (16%)

Query: 383 EEEMEMSDDEIEEMTETKETEES-----------------------ALVSQAEALKEEND 419
           +EE++  + +++E  +  E+E+S                        L ++A+ L +E  
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275

Query: 420 SLRWQLDAYRNEVELL----KQEQGKVHREDDPNKEQQLKLLQQALQ-GMQQHLLKVQEE 474
           S+  +L A   E EL     +Q++ K+ R+++  +E + K+ +Q  +   Q+  ++ QEE
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE 335

Query: 475 YKKKEAELEKLKDDKL-QVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSER 533
             +++ E+   K++K+ + E+M+   +EK      +    ++    LE+ M+      E+
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395

Query: 534 E 534
           E
Sbjct: 396 E 396



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 34/129 (26%), Positives = 63/129 (48%), Gaps = 18/129 (13%)

Query: 392 EIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKE 451
           E+E+      T++       E L +E D+L   L+ YRN +             D+  KE
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDAL--SLELYRNTI------------TDEELKE 221

Query: 452 QQLKLLQQALQGMQQHLLKVQEEYK--KKEAELEKLKDDKLQVEKMLENL-KEKESCASR 508
           +  K LQ+ LQ ++    ++Q   K  K++ E  KL   + Q++   ++L KE +S +++
Sbjct: 222 KNAK-LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280

Query: 509 LCASNQDSE 517
           L A  +++E
Sbjct: 281 LQAQVEENE 289


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 54/258 (20%), Positives = 117/258 (45%), Gaps = 11/258 (4%)

Query: 291 SMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSA--SKQKAW 348
           ++I     ++  LV      +K      +K  ++L  +  Q  + +A    A  SK +  
Sbjct: 103 AIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQL 162

Query: 349 DHFTKAQRKNISVWCKQAE-EIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESAL 407
              T   RK +    +Q + E+ N     L+  R+EE +   ++ + E  E    +E  L
Sbjct: 163 QDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERL 222

Query: 408 VSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDP--NKEQQLKLLQQALQGMQ 465
             Q E L+E+ + LR Q +    + E L++ + ++  +++    +E++L+  ++ L   +
Sbjct: 223 CEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQE 282

Query: 466 QHLLKVQEEYKKKEAEL----EKLKDDKLQVEKMLENLKEKES--CASRLCASNQDSEYP 519
           + L + +E  +++E  L    E+L++ + ++ +  E L+E+E   C        +     
Sbjct: 283 ERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEE 342

Query: 520 LEKTMNSSPIKSEREALL 537
           +EK +     + E+E LL
Sbjct: 343 VEKLLEQERRQEEQERLL 360



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 46/205 (22%), Positives = 99/205 (48%), Gaps = 19/205 (9%)

Query: 297 NSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQR 356
           N+ +  L+N +   E+ + E +E+ ++    +  Q E++        +Q+      +  R
Sbjct: 186 NNQMLSLLNRR--QEERLREQEERLREQEERLREQEERLCEQEERLREQE------ERLR 237

Query: 357 KNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKE 416
           +     C+Q E +R  H + L    +EE +   ++ + E  E    +E  L  Q E L+E
Sbjct: 238 EQEERLCEQEERLRE-HEERLC--EQEERLCEQEERLREQEERLHEQEERLCEQEERLRE 294

Query: 417 ENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYK 476
           + + L  Q +  R + E L +++ ++       +EQ+ +L +Q     Q+ LL+  E+  
Sbjct: 295 QEERLCEQEERLREQEERLCEQEERL-------REQEERLCEQEKLPGQERLLEEVEKLL 347

Query: 477 KKEAELEKLKDDKLQVEKMLENLKE 501
           ++E   E+ ++  L+ E++LE ++E
Sbjct: 348 EQERRQEE-QERLLERERLLEEVEE 371



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 58/287 (20%), Positives = 118/287 (41%), Gaps = 39/287 (13%)

Query: 220 MLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKD-DSKFSEAVQTLLTWIER 278
           +L R +  R R +EERLR                   E+L++ + +  E  + L    E+
Sbjct: 192 LLNRRQEERLREQEERLREQE----------------ERLREQEERLCEQEERLR---EQ 232

Query: 279 GEVNRRSANNFYSMIQSANSHVRRLVNEK---AAHEKDMEEAKEKFKQALSGILIQFEQI 335
            E  R          +    H  RL  ++      E+ + E +E+  +    +  Q E++
Sbjct: 233 EERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERL 292

Query: 336 VAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEE 395
                   +Q+      +  R+     C+Q E +R    + L    +    E   +E+E+
Sbjct: 293 REQEERLCEQE------ERLREQEERLCEQEERLRE-QEERLCEQEKLPGQERLLEEVEK 345

Query: 396 MTE-TKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQL 454
           + E  +  EE   + + E L EE + L         E E L+Q+  ++ +++   + ++L
Sbjct: 346 LLEQERRQEEQERLLERERLLEEVEELL--------EQERLRQQDERLWQQETLQELERL 397

Query: 455 KLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE 501
           + L++ L+   + L + + E +    EL       LQ+E+ ++ LK+
Sbjct: 398 RELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKK 444


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 82/374 (21%), Positives = 151/374 (40%), Gaps = 51/374 (13%)

Query: 185  RIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPV 244
            R   G    K   G L       RD   E EC+Q  +   +  + ++E++          
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG------- 1761

Query: 245  VHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSA----NSHV 300
            +H    E S++  + + +    +  Q L    E+GE+  +S  +     Q A    +  +
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQ--QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL 1819

Query: 301  RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQR--KN 358
              L  E+   +   E  KEK   AL G L Q    +   H   +    DH  +A+R  + 
Sbjct: 1820 EALQQEQQQAQGQEERVKEK-ADALQGALEQAHMTLKERHGELQ----DHKEQARRLEEE 1874

Query: 359  ISVWCKQAEEIRNIHNDELMGIRREE------EMEMSDDEIEEMTETKETEESALVSQA- 411
            ++V  ++ + +  +  D     R +E      + + ++   E   ET+  ++S L +QA 
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934

Query: 412  --------EALKEENDSLRWQLDAYRNEVELLKQEQGKVH-------------REDDPNK 450
                    EAL+ E+ S R Q +A R   E L++  GK H              E   + 
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994

Query: 451  EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLC 510
            E     LQ +L   Q H  +++E  + +E E++   D  L+ ++ ++ L++  +      
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQ---DQDLRYQEDVQQLQQALAQRDEEL 2051

Query: 511  ASNQDSEYPLEKTM 524
               Q+ E  LEK++
Sbjct: 2052 RHQQEREQLLEKSL 2065



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 55/265 (20%), Positives = 116/265 (43%), Gaps = 38/265 (14%)

Query: 277  ERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIV 336
            ER +  +        + Q+       L  +KAAHEK++ + +EK+++  S          
Sbjct: 818  ERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS---------- 867

Query: 337  AVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEM 396
              +H     KA +     +R+ + +  +  E+   +   E +  +REEE   ++  + +M
Sbjct: 868  --WHQQELAKALE---SLEREKMELEMRLKEQQTEM---EAIQAQREEERTQAESALCQM 919

Query: 397  TETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKL 456
                E E  +L+      ++E      QL+  R ++++ K ++           ++   +
Sbjct: 920  QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE-----------QETTGI 968

Query: 457  LQQALQGMQQHLLKVQEEYKKKEAELEK----LKDDKLQVEKMLENLKEK---ESCASRL 509
            LQ  LQ  Q+ L +   +++   A L++    L  DK+ ++K +E+LK +   +  + RL
Sbjct: 969  LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028

Query: 510  CASNQDSEYPLEKTMNSSPIKSERE 534
                Q+ +  L +T   + I+ E E
Sbjct: 1029 V--EQEVQEKLRETQEYNRIQKELE 1051



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 60/322 (18%), Positives = 135/322 (41%), Gaps = 47/322 (14%)

Query: 267  EAVQTLLTWIERGEVNRRSANNFYSMIQSANS-------HVRRLVNEKAAHEKDMEEAKE 319
            E + +L + + R E+ R  A     ++Q+A         H++  V E  A        +E
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEE 1379

Query: 320  KFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRK----NISVWCKQAEEIRNIHND 375
              + A S + ++ E++ +    A   +       AQ K    N+++  +   E       
Sbjct: 1380 DLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE------- 1432

Query: 376  ELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELL 435
                  REEE+E    +I+E+ + +E +++AL   +  LK+ N     ++D  + +++ L
Sbjct: 1433 ------REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ----EVDLQQEQIQEL 1482

Query: 436  KQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEK- 494
            ++ +  +       +E++ KL  Q  Q        ++E  K +E +   L+   L++EK 
Sbjct: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQ--------IRELEKDRETQRNVLEHQLLELEKK 1534

Query: 495  ---------MLENLKEKESCASRLCASNQDSEYPLE-KTMNSSPIKSEREALLVGIISTF 544
                      +++LK++      L    +++ + +E +      ++ +RE   V +    
Sbjct: 1535 DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLT 1594

Query: 545  LHVHPFGASIEYICSYLHRLDN 566
            L +      ++   S +H L++
Sbjct: 1595 LDLEERSQELQAQSSQIHDLES 1616



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/231 (24%), Positives = 105/231 (45%), Gaps = 40/231 (17%)

Query: 296  ANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQ 355
            A     R   E A  +  +E  KE+   +L   L+Q ++ +A    AS+Q       +  
Sbjct: 903  AQREEERTQAESALCQMQLETEKERV--SLLETLLQTQKELA---DASQQ------LERL 951

Query: 356  RKNISVWCKQAEEIRNIHNDELMGIRRE--EEMEMSDDEIEEMTETKETEESALVSQAEA 413
            R+++ V   + +E   I   +L   +RE  E      D++  + E    E S+L+     
Sbjct: 952  RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQE----ESSSLLQDKMD 1007

Query: 414  LKEENDSLRWQLDAYRNEVELLKQE-QGKVHREDDPN-------------------KEQQ 453
            L+++ + L+ QL A  +   L++QE Q K+    + N                   KEQ+
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067

Query: 454  LKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKES 504
            L +LQ+A    QQ L  ++++ ++ + E ++L     Q+E + + +KEKE+
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKEL---SAQMELLRQEVKEKEA 1115



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/165 (25%), Positives = 80/165 (48%), Gaps = 8/165 (4%)

Query: 356 RKNISVWCKQAEEIRNIHND-ELMGIRREEEMEMSDDEIEEMTETKETEESALVS----Q 410
           R+ + V  ++A  +R ++ + +L G   + + E   +E+      +E  +  L+     Q
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQ 535

Query: 411 AEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLK 470
           +E+L E   +LR  L++   E ELL+QEQ +V        EQ +  L  +   ++  +  
Sbjct: 536 SESLSELI-TLREALESSHLEGELLRQEQTEV-TAALARAEQSIAELSSSENTLKTEVAD 593

Query: 471 VQEEYKKKEAELEKLKDDKLQVEKMLENLKEK-ESCASRLCASNQ 514
           ++    K  A  E L  DK+ + + L  L+E+ +S  SR+ A+ Q
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638



 Score = 36.6 bits (83), Expect = 0.069
 Identities = 39/217 (17%), Positives = 103/217 (47%), Gaps = 12/217 (5%)

Query: 312  KDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRN 371
            +DM+  K K ++    +  Q ++       A++Q   D     Q ++ S+   + +  + 
Sbjct: 953  QDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR-DDLAALQEESSSLLQDKMDLQKQ 1011

Query: 372  IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRN- 430
            + + +   + +++   + + E++E  + +ET+E   + +   L+ E  SL   L      
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQE--KLRETQEYNRIQKE--LEREKASLTLSLMEKEQR 1067

Query: 431  -----EVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAE-LEK 484
                 E + ++Q++    R+D    + + K L   ++ ++Q + + + ++  +EA+ LE+
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127

Query: 485  LKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLE 521
            L+   +  +++  +L  +E+ A++L    + +E  LE
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 69/313 (22%), Positives = 135/313 (43%), Gaps = 20/313 (6%)

Query: 194 KKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVV---HYSDH 250
           ++D  +L VD+++ARD+L   E + +M     +   + E  RL       V    H+ + 
Sbjct: 135 REDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEM 194

Query: 251 ECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLV------ 304
           + +   + ++  ++      +LLT   R  V  +S     S         + L+      
Sbjct: 195 KSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254

Query: 305 -NEKAAHEKDMEEAKEKFKQALSGILIQ--FEQIVAVYHSASKQ-KAWDHFTKAQRKNIS 360
             EK AHE+  E  + K +  L    +Q    ++ A+   + KQ + ++   KA R+ + 
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314

Query: 361 VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTE--TKETEESALVSQAEALKEEN 418
           +      E+   H   L    +EE++ +    I+++T+   +E +  A  S  E   E +
Sbjct: 315 ILETNHTELME-HEASLSRNAQEEKLSL-QQVIKDITQVMVEEGDNIAQGSGHENSLELD 372

Query: 419 DSLRWQLDAYRNEVELLKQEQGKV--HREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYK 476
            S+  Q D Y++  + L   +  +   R+   +  QQL   Q+A+  +QQ   + +EE K
Sbjct: 373 SSIFSQFD-YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431

Query: 477 KKEAELEKLKDDK 489
                L+KL  ++
Sbjct: 432 ALRQRLQKLTGER 444



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 10/153 (6%)

Query: 366 AEEIRN-IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQ 424
           AE+ RN +  D     +R E +   +  +E   +  E   + L +    ++EE + ++ +
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695

Query: 425 LDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEK 484
           L   R++ E    +  ++H+E     ++Q ++L +A+Q  +     +  E    E  L+ 
Sbjct: 696 LSESRHQQEAATTQLEQLHQE----AKRQEEVLARAVQEKE----ALVREKAALEVRLQA 747

Query: 485 LKDDKLQVEKMLENLKE-KESCASRLCASNQDS 516
           ++ D+  + + L+ L   KE   S L  + Q +
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780



 Score = 32.7 bits (73), Expect = 1.00
 Identities = 26/119 (21%), Positives = 62/119 (52%), Gaps = 8/119 (6%)

Query: 393 IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQ 452
           +++  +  E E  AL  + + L  E D+L  Q    + EV+ L +E+  + +  +    Q
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE-ELRQ 477

Query: 453 QLKLLQQALQGMQQHLLKV-------QEEYKKKEAELEKLKDDKLQVEKMLENLKEKES 504
           QL++L+Q    +++  +++       Q + ++++ EL     ++ ++++ML  L+ K+S
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQS 536



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 39/163 (23%), Positives = 77/163 (47%), Gaps = 25/163 (15%)

Query: 363 CKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLR 422
           C++A  +    +D+      EEE +     ++++T  ++T    L  Q   L+ E DSL 
Sbjct: 412 CQEAVNLLQQQHDQW-----EEEGKALRQRLQKLTGERDT----LAGQTVDLQGEVDSLS 462

Query: 423 WQ-------LDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEY 475
            +        +  R ++E+L+QE  ++ R +      +L+L   + QG ++   + QEE 
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVN-----VELQLQGDSAQGQKE---EQQEEL 514

Query: 476 KKKEAELEKLKDDKLQVE-KMLENLKEKESCASRLCASNQDSE 517
                E E+L++  + +E K  E+L E  +    L +S+ + E
Sbjct: 515 HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/378 (21%), Positives = 165/378 (43%), Gaps = 36/378 (9%)

Query: 171 EEYMVDKALYLSGYRIRLGSSTDKKDTGR------LHVDFAQARDDLYEWECKQRMLARE 224
           + Y   K + +    +RLG  T +K          LH D A       E   K+R     
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSL 204

Query: 225 ERHRRRMEEERLRPPSPP--PVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVN 282
           E +R  + +E L+  +      +   + E S +   +KD  +  E  Q LL   +     
Sbjct: 205 ELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQL---- 260

Query: 283 RRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSA 342
           +  A+     +QS ++ ++  V E        ++ +EK  +       Q E+I       
Sbjct: 261 QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWR-------QEEKI-----QE 308

Query: 343 SKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKET 402
            ++K  +   K + +   +W +Q E++   H  E     +E++M   +++I E  E    
Sbjct: 309 QEEKMCEQELKIREQEEKMW-RQEEKM---HEQEEKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 403 EESALVSQAEALKEENDSLRWQLDA-YRNEVELLKQE---QGKVHREDDPNKEQQLKLLQ 458
           +E  +  Q E ++E+++ ++ Q +  +R E ++ +QE   Q K+ R++   +EQ  K+ +
Sbjct: 365 QEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424

Query: 459 QALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEY 518
           Q  +  +Q   K++E  +  + + EKL++ + ++++  E ++E+E    R     Q+ E 
Sbjct: 425 QEEEMWRQEE-KIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQE- 482

Query: 519 PLEKTMNSSPIKSEREAL 536
             EKT     +  + E +
Sbjct: 483 --EKTWRQEKLLKQEEKI 498



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/209 (23%), Positives = 103/209 (49%), Gaps = 18/209 (8%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ--KAW-------DHFTKAQRKNISV 361
           E+ M E +EK ++    +  Q E+I        +Q  K W       +   K Q +   +
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390

Query: 362 WCKQAEEIRNIHNDELMGI-RREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS 420
           W +Q E+IR         + R+E++M   D++I E  E    +E  +    E ++++ + 
Sbjct: 391 W-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEK 449

Query: 421 LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQ------QLKLLQQALQGMQQHLLKVQEE 474
           LR   +  + E E +++++ K+ R+++  +EQ      Q KLL+Q  +  +Q     ++E
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509

Query: 475 YKKKEAELEKLKDDKLQVEKMLENLKEKE 503
            K  E E EK+++ + ++++  E ++E+E
Sbjct: 510 EKMWEQE-EKMQEQEEKMQRQEEKMREQE 537



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/212 (20%), Positives = 104/212 (49%), Gaps = 9/212 (4%)

Query: 300 VRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKA--WDHFTKAQRK 357
           +R   ++    E+ + E +EK ++    +  Q E+I        +Q+   W    K + +
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ 400

Query: 358 NISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEE 417
                 K   + + +   +     +EEEM   +++I E+ E  + +E  L    E ++EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460

Query: 418 NDSLRWQLDAYRNEVELLKQEQGKVHREDDPNK------EQQLKLLQQALQGMQQHLLKV 471
            + ++ Q +  + + E +++++ K  R++   K      EQ+ K+ +Q  + M +   K+
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE-EKMWEQEEKM 519

Query: 472 QEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           QE+ +K + + EK+++ ++++ +  E ++E+E
Sbjct: 520 QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 80/378 (21%), Positives = 165/378 (43%), Gaps = 36/378 (9%)

Query: 171 EEYMVDKALYLSGYRIRLGSSTDKKDTGR------LHVDFAQARDDLYEWECKQRMLARE 224
           + Y   K + +    +RLG  T +K          LH D A       E   K+R     
Sbjct: 145 KNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSL 204

Query: 225 ERHRRRMEEERLRPPSPP--PVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVN 282
           E +R  + +E L+  +      +   + E S +   +KD  +  E  Q LL   +     
Sbjct: 205 ELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQL---- 260

Query: 283 RRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSA 342
           +  A+     +QS ++ ++  V E        ++ +EK  +       Q E+I       
Sbjct: 261 QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWR-------QEEKI-----QE 308

Query: 343 SKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKET 402
            ++K  +   K + +   +W +Q E++   H  E     +E++M   +++I E  E    
Sbjct: 309 QEEKMCEQELKIREQEEKMW-RQEEKM---HEQEEKIREQEDKMWRQEEKIREQEEKIRE 364

Query: 403 EESALVSQAEALKEENDSLRWQLDA-YRNEVELLKQE---QGKVHREDDPNKEQQLKLLQ 458
           +E  +  Q E ++E+++ ++ Q +  +R E ++ +QE   Q K+ R++   +EQ  K+ +
Sbjct: 365 QEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424

Query: 459 QALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEY 518
           Q  +  +Q   K++E  +  + + EKL++ + ++++  E ++E+E    R     Q+ E 
Sbjct: 425 QEEEMWRQEE-KIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQE- 482

Query: 519 PLEKTMNSSPIKSEREAL 536
             EKT     +  + E +
Sbjct: 483 --EKTWRQEKLLKQEEKI 498



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/209 (23%), Positives = 103/209 (49%), Gaps = 18/209 (8%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ--KAW-------DHFTKAQRKNISV 361
           E+ M E +EK ++    +  Q E+I        +Q  K W       +   K Q +   +
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390

Query: 362 WCKQAEEIRNIHNDELMGI-RREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS 420
           W +Q E+IR         + R+E++M   D++I E  E    +E  +    E ++++ + 
Sbjct: 391 W-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEK 449

Query: 421 LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQ------QLKLLQQALQGMQQHLLKVQEE 474
           LR   +  + E E +++++ K+ R+++  +EQ      Q KLL+Q  +  +Q     ++E
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509

Query: 475 YKKKEAELEKLKDDKLQVEKMLENLKEKE 503
            K  E E EK+++ + ++++  E ++E+E
Sbjct: 510 EKMWEQE-EKMQEQEEKMQRQEEKMREQE 537



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 43/212 (20%), Positives = 104/212 (49%), Gaps = 9/212 (4%)

Query: 300 VRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKA--WDHFTKAQRK 357
           +R   ++    E+ + E +EK ++    +  Q E+I        +Q+   W    K + +
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ 400

Query: 358 NISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEE 417
                 K   + + +   +     +EEEM   +++I E+ E  + +E  L    E ++EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460

Query: 418 NDSLRWQLDAYRNEVELLKQEQGKVHREDDPNK------EQQLKLLQQALQGMQQHLLKV 471
            + ++ Q +  + + E +++++ K  R++   K      EQ+ K+ +Q  + M +   K+
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE-EKMWEQEEKM 519

Query: 472 QEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           QE+ +K + + EK+++ ++++ +  E ++E+E
Sbjct: 520 QEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 58/228 (25%), Positives = 109/228 (47%), Gaps = 26/228 (11%)

Query: 295  SANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKA 354
            S    V  LV++    E+ + + KE+ K + S +      + ++  S +K+K     T+ 
Sbjct: 929  SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK---QVTEE 985

Query: 355  QRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDE-------IEEMTETKETEESAL 407
             RKNI V  K++ E +     +LM + +E++ E+ DD+        ++++E K+T  S  
Sbjct: 986  VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQ-ELQDDKRRAIESMEQQLSELKKTLSSVQ 1044

Query: 408  VSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQ---QALQGM 464
                EAL+  + +L  +  A R+      QEQ K+  E     E++L L     +ALQ  
Sbjct: 1045 NEVQEALQRASTALSNEQQARRD-----CQEQAKIAVEAQNKYERELMLHAADVEALQAA 1099

Query: 465  QQHLLK-------VQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESC 505
            ++ + K       ++E  +K E++L + K    + E+ML++   K  C
Sbjct: 1100 KEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVC 1147



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 88/382 (23%), Positives = 156/382 (40%), Gaps = 56/382 (14%)

Query: 199  RLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEE--RLRPPSPPPVVHYSDHECSIVA 256
            +L +D    ++   E   K  ML  E   ++ +EE+  R +  +   V    D +     
Sbjct: 1299 KLELDILPLQEANAELSEKSGMLQAE---KKLLEEDVKRWKARNQHLVSQQKDPDTEEYR 1355

Query: 257  EKLKDDSKFSEAVQTLLTWIER--GEVNRRSAN--NFYSMIQSANSHVRRLVNEKAAHEK 312
            + L +    ++ +Q L   I R   E+ R +A+  N  ++IQS    + ++  EK   +K
Sbjct: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK 1415

Query: 313  DME----EAKEKFKQALSGILI------QFEQIVAVYHSA---SKQKAWDHFTKAQRKNI 359
            D++    + +EK K       I      Q+E++ A        S Q + DH    Q +++
Sbjct: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDH----QEQHV 1471

Query: 360  SVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEEND 419
            SV  ++ +E++   N       + + +E   + +++    KETE   L  Q   L+ E  
Sbjct: 1472 SV--QEMQELKETLNQ---AETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS 1526

Query: 420  SLRWQLDAYRNEVELLKQEQGKVHREDDPNKE-QQLKLLQQALQGMQQHLLKVQEEYKKK 478
             LR  L     + E L+Q+     +E+   K     K     L G++  L K  EE K++
Sbjct: 1527 RLRQDLQDRTTQEEQLRQQ--ITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQR 1584

Query: 479  EAELEKLKDD--------KLQVEKMLENL-KEKESCASRLCASNQDSEYPLEK------- 522
               L++ KD+        K Q E  +  L +E      R      + + P  K       
Sbjct: 1585 NGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644

Query: 523  -TMNSSPIKSEREALLVGIIST 543
             T+ ++P   ER     GI ST
Sbjct: 1645 ITLKTTPASGER-----GIAST 1661



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 48/175 (27%), Positives = 78/175 (44%), Gaps = 38/175 (21%)

Query: 375 DELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVEL 434
           DEL+ + RE+  E+   E++   E K+ E S L  Q   LK  N+ L+  ++    +++ 
Sbjct: 206 DELLALGREKGNEIL--ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE 263

Query: 435 LKQEQG----KVHRE----------------DDPNKEQQL--------KLLQ---QALQG 463
            K++Q     K H E                D   K  +L        KLL+   +A + 
Sbjct: 264 AKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKA 323

Query: 464 MQQHLLKVQEEYKKKEAE-LEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSE 517
           +Q HLL+V++   + E E LEK+     ++EK LEN  +  S   R  A   + E
Sbjct: 324 IQDHLLEVEQSKDQMEKEMLEKIG----RLEKELENANDLLSATKRKGAILSEEE 374



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 32/209 (15%)

Query: 306 EKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQ 365
           EKA +EK   E  EK ++ ++ +                        ++Q   IS     
Sbjct: 685 EKAENEKIQNEQLEKLQEQVTDL------------------------RSQNTKISTQLDF 720

Query: 366 AEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSL---R 422
           A +   +  D + G RR  E+    +  +++T T + +E  + +  + L+  N+ L    
Sbjct: 721 ASKRYEMLQDNVEGYRR--EITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE 778

Query: 423 WQLDAYRNEVELLKQEQGKV--HREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKK-E 479
            + +  + E E+LK  + ++   RE    +++   LL   LQ +Q  L + + E K++  
Sbjct: 779 VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLS 838

Query: 480 AELEKLKDDKLQVEKMLENLKEKESCASR 508
           +++EKL+ +   ++K LEN  E+    +R
Sbjct: 839 SQIEKLEHEISHLKKKLENEVEQRHTLTR 867



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 31/144 (21%), Positives = 70/144 (48%), Gaps = 13/144 (9%)

Query: 376  ELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELL 435
            ++  +R  + +E+ + E++E+ ++   E   +   A+ + +  + ++      + E   +
Sbjct: 1218 QVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK------KTETMNV 1271

Query: 436  KQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKM 495
              E  K+ RE+    EQ L+ +Q  ++ ++  +L +QE      AEL + K   LQ EK 
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE----ANAELSE-KSGMLQAEKK 1326

Query: 496  L--ENLKEKESCASRLCASNQDSE 517
            L  E++K  ++    L +  +D +
Sbjct: 1327 LLEEDVKRWKARNQHLVSQQKDPD 1350



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 36/165 (21%), Positives = 81/165 (49%), Gaps = 13/165 (7%)

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETK---ETEESALVSQAEALKEENDS 420
           KQ +EI   +  E     + E  ++ ++++E++ E      ++ + + +Q +   +  + 
Sbjct: 673 KQLQEIFENYKKE-----KAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM 727

Query: 421 LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHL--LKVQEEYKKK 478
           L+  ++ YR E+  L +   K+       +EQ +  + Q L+G  + L   +V+ E  KK
Sbjct: 728 LQDNVEGYRREITSLHERNQKLTATTQ-KQEQIINTMTQDLRGANEKLAVAEVRAENLKK 786

Query: 479 EAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKT 523
           E E+ KL + +L  ++  E+L  ++   + L  + Q  +  LE++
Sbjct: 787 EKEMLKLSEVRLSQQR--ESLLAEQRGQNLLLTNLQTIQGILERS 829



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 39/164 (23%), Positives = 76/164 (46%), Gaps = 22/164 (13%)

Query: 354  AQRKNISVWCK---QAEEIRNIHNDELMGIRRE------EEMEMSDDEIEEMTETKETEE 404
            A+R+ + V  K   Q EE+  +   E M +  E      EE E  + ++++M       E
Sbjct: 1244 AEREKVQVTAKTMAQHEEL--MKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301

Query: 405  SALVSQAEA---LKEENDSLRWQLDAYRNEVELLK-QEQGKVHREDDPNKEQQLKLLQQA 460
              ++   EA   L E++  L+ +      +V+  K + Q  V ++ DP+ E+  KLL + 
Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEK 1361

Query: 461  LQGMQQHLLKVQ---EEYKKKEAELEKLKDDKLQVEKMLENLKE 501
                + H  ++Q   EE  + +AE+ +        + ++++LKE
Sbjct: 1362 ----EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKE 1401



 Score = 32.7 bits (73), Expect = 1.00
 Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 25/252 (9%)

Query: 298 SHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQK----------- 346
           S   R   E  A ++D+    E+  Q L  +    +++      ++  K           
Sbjct: 111 SQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQ 170

Query: 347 AWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESA 406
           A D   K + K +    +Q +E+ +  N  L       E++   DE+  +   K  E   
Sbjct: 171 ASDVSVKYREKRL----EQEKELLHSQNTWL-----NTELKTKTDELLALGREKGNEILE 221

Query: 407 LVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQ 466
           L    E  KEE   L  Q++  +   E L++    +  +    KEQQ  + ++    +  
Sbjct: 222 LKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNA 281

Query: 467 HLLKVQEEYKK----KEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEK 522
           H +K+   YK      EA+  +L     ++ K+L+   E            + S+  +EK
Sbjct: 282 H-IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340

Query: 523 TMNSSPIKSERE 534
            M     + E+E
Sbjct: 341 EMLEKIGRLEKE 352



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 57/295 (19%), Positives = 123/295 (41%), Gaps = 30/295 (10%)

Query: 269 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGI 328
           V+ LLT ++  +  + S    +      N+H++     K+A   D  EAK      L+  
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFH--NELNAHIKLSNLYKSA--ADDSEAKSN---ELTRA 306

Query: 329 LIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHND-----ELMGIRRE 383
           + +  +++     A+K    DH  + ++    +  +  E+I  +  +     +L+   + 
Sbjct: 307 VEELHKLLKEAGEANKA-IQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKR 365

Query: 384 EEMEMSDDEIEEMTET------------KETE-ESALVSQAEAL---KEENDSLRWQLDA 427
           +   +S++E+  M+ T            K TE  +A V   + L   K EN  +   LD 
Sbjct: 366 KGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDE 425

Query: 428 YRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKD 487
              EVE  K    K  RE+    ++ +  L   L+   + + ++QE+  K   +   L+ 
Sbjct: 426 IVKEVEA-KAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLER 484

Query: 488 DKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIIS 542
           D  ++E  +++L ++           + +    ++ ++S+ I S  E +   ++S
Sbjct: 485 DNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVS 539



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 50/255 (19%), Positives = 98/255 (38%), Gaps = 42/255 (16%)

Query: 375  DELMGIRREEEMEMSD--DEIEEMTETKETEESALVSQAEALKEEND------------- 419
            D+L+   R+ E +++D  + ++  T   E  ++ + S  E+L +E               
Sbjct: 935  DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRL 994

Query: 420  ----SLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEY 475
                  + QL+    EVE  KQE     R    + EQQL  L++ L  +Q  + +  +  
Sbjct: 995  KESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRA 1054

Query: 476  K-------------KKEAELEKLKDDKLQVEKML-----ENLKEKESCASRLCASNQDSE 517
                          +++A++     +K + E ML     E L+  +   S++ +  Q  E
Sbjct: 1055 STALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLE 1114

Query: 518  YPLEKT----MNSSPIKSEREALLVGIISTFL-HVHPFGASIEYICSYLHRLDNKICTSD 572
               +K     +       ERE +L   +S  +            +   + +L +K+  S 
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV 1174

Query: 573  VECLMGRLQHTFKQE 587
             E + G L  +  +E
Sbjct: 1175 KEGVQGPLNVSLSEE 1189


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 107/521 (20%), Positives = 204/521 (39%), Gaps = 102/521 (19%)

Query: 46  NLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKS 105
           +L   P+GI   P LP          GIPP  P  PG    PPP+PP  P++   +    
Sbjct: 6   HLNRPPMGI---PALPP---------GIPP--PQFPGF---PPPVPPGTPMIPVPM---- 44

Query: 106 CTLFPPNPNLPPPAT---------RERPPGCK------------TVFVGGLPENGTEQII 144
            ++  P P +  P           R+  PG K            TVFVG + E  ++ +I
Sbjct: 45  -SIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLI 103

Query: 145 VEVFEQCGEIIAIRKSKK--------NFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKD 196
            ++  +CG +++ ++ +          FC  +  E  +  +AL L  + +++G   +KK 
Sbjct: 104 RQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTL--RALRLL-HDLQIG---EKKL 157

Query: 197 TGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVA 256
             ++    A+ +  L EW+ K++      R                P    +D E ++  
Sbjct: 158 LVKVD---AKTKAQLDEWKAKKKASNGNAR----------------PETVTNDDEEALDE 198

Query: 257 EKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEE 316
           E  + D     A++ L+         R  ++   +  Q ++SH R+   EK       E+
Sbjct: 199 ETKRRDQMIKGAIEVLI---------REYSSELNAPSQESDSHPRKKKKEK------KED 243

Query: 317 AKEKFKQA--LSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHN 374
              +F  A  +   LI  E I A+     K+          R       K+ EE +    
Sbjct: 244 IFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDT----HKKLEEEKGKKE 299

Query: 375 DELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVEL 434
            E   I +E      + E E     +E E      + E  KE+      + D  R+  + 
Sbjct: 300 KERQEIEKERRERERERERERERRERERERE---REREREKEKERERERERDRDRDRTKE 356

Query: 435 LKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEK 494
             +++ +  R+ D ++E+     +   +  ++   + +E  +++E E E+ ++ + + E+
Sbjct: 357 RDRDRDR-ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER 415

Query: 495 MLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREA 535
             E  +E+E    +     +D E   E+      ++ E+EA
Sbjct: 416 EREREREREREKDKKRDREEDEEDAYERRKLERKLR-EKEA 455



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 57/304 (18%), Positives = 119/304 (39%), Gaps = 18/304 (5%)

Query: 213 EWECKQRMLARE-ERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQT 271
           E E ++R   RE ER RR  E ER R           + E     E+ +D  +  E  + 
Sbjct: 306 EKERRERERERERERERRERERERERERE-----REKEKERERERERDRDRDRTKERDRD 360

Query: 272 LLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQ 331
                +R     RS++      +S      R    +   E++ E  +E+ ++       +
Sbjct: 361 RDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERE 420

Query: 332 FEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDD 391
            E+         +++  +   + ++    +  K+A     + N E+   ++  E E   +
Sbjct: 421 REREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE 480

Query: 392 EIEEMTETKETEESALVSQAEALKEENDSLRWQLDA-----YRNEVELLKQEQGKVHRED 446
             EE       E   L    E   ++ D  ++   +      R+  + ++ ++    RE 
Sbjct: 481 REEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540

Query: 447 DPNKEQQLKLLQQA-------LQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENL 499
           +  +E + +LL +        LQ M+Q   + ++   K+E E E+ +++K + E+  E  
Sbjct: 541 EELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600

Query: 500 KEKE 503
            E+E
Sbjct: 601 MEEE 604


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 57/242 (23%), Positives = 120/242 (49%), Gaps = 29/242 (11%)

Query: 316  EAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHND 375
            +A  K +Q LS + +  ++  A Y      + W  FTK   K +    +Q EE++   ++
Sbjct: 804  KAFAKKQQQLSALKV-LQRNCAAYLKLRHWQWWRVFTKV--KPLLQVTRQEEELQ-AKDE 859

Query: 376  ELMGIRREE-EMEMSDDEIEEMTETKETEESALVSQAEALKE---ENDSLRWQLDAYRNE 431
            EL+ ++ ++ ++E   +E+E   +    E++ L  Q +A  E   E + +R +L A + E
Sbjct: 860  ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQE 919

Query: 432  VE-LLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKL 490
            +E +L   + +V  E++ N+     +LQ   + MQ H+  ++E+  ++E   +KL+ +K+
Sbjct: 920  LEEILHDLESRVEEEEERNQ-----ILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974

Query: 491  ----QVEKMLEN-----------LKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREA 535
                +++KM E            +KEK+    R+   +       EK  N + I++++E 
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 536  LL 537
            ++
Sbjct: 1035 MI 1036



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 52/234 (22%), Positives = 106/234 (45%), Gaps = 23/234 (9%)

Query: 277  ERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIV 336
            E  E  R++       +QS  +  ++ V++     + +EEAK+K  +    +  + E+  
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412

Query: 337  AVYHSASK-----QKAWDHFT---KAQRKNIS-VWCKQAEEIRNIHNDELMGIRREEEME 387
              Y    K     Q+  D  T     QR+  S +  KQ +  + +  ++ +  R  EE +
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472

Query: 388  MSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGK-VHRED 446
             ++ E  E  ETK    +  + +A   KEE +    QL A   ++   K + GK VH   
Sbjct: 1473 RAEAEARE-KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-- 1529

Query: 447  DPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLK 500
                      L+++ + ++Q + +++ + ++ E EL+  +D KL++E  ++ +K
Sbjct: 1530 ----------LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 44/224 (19%), Positives = 98/224 (43%), Gaps = 31/224 (13%)

Query: 293  IQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFT 352
            +Q+ +  + ++  ++   E ++EE + K +Q L    I  EQ+         Q   + F 
Sbjct: 854  LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL---------QAETELFA 904

Query: 353  KAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAE 412
            +A+     +  K+ E    +H           ++E   +E EE  +  + E+  + +  +
Sbjct: 905  EAEEMRARLAAKKQELEEILH-----------DLESRVEEEEERNQILQNEKKKMQAHIQ 953

Query: 413  ALKEENDS-----LRWQLDAYRNEVELLKQEQGKVHREDDPNK-EQQLKLLQQALQGMQQ 466
             L+E+ D       + QL+    E ++ K E+  +  ED  +K  ++ KL++  +     
Sbjct: 954  DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013

Query: 467  HLLKVQEEYKKKEAELEKLKD-DKLQVEKMLENLKEKESCASRL 509
             L + +E+ K     L K+++  ++ +  + E LK++E     L
Sbjct: 1014 QLAEEEEKAK----NLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 72/377 (19%), Positives = 148/377 (39%), Gaps = 61/377 (16%)

Query: 218  QRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDD-SKFSEAVQTLLTWI 276
            +  L +EE+ R+ +E+ + +       +     E     ++LK   +K  E +Q  L   
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA-- 1097

Query: 277  ERGEVNRRSANNFYSMIQSANSHVRRLV----NEKAAHEK------DMEEAKEKFKQALS 326
             RG+      NN   +++   + +  L     +EKA+  K      D+ E  E  K  L 
Sbjct: 1098 -RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE 1156

Query: 327  GIL----------IQFEQIVAVYHSASKQKAWDHFTKAQR---------KNISVWCKQAE 367
              L           + EQ VA    A +++  +H  + Q          + +S   +QA+
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 368  EIRNIHNDELMGIRREEEMEMSD----DEIEEMTETKETEESALVSQAEALKEENDSLRW 423
              +        G+  + +    +     +++  +E K  +  A V +  A   E D LR 
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276

Query: 424  QL----DAYRNEVELLK------QEQGKVHREDDPNKEQQLKLLQQALQG---------- 463
            +L       +NE++ +       +++G    +D  + E QL+  Q+ LQ           
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336

Query: 464  ----MQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYP 519
                +++    +QE+ +++E   + L+   L ++  L + K+K         S ++++  
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396

Query: 520  LEKTMNSSPIKSEREAL 536
            L K   +   + E +AL
Sbjct: 1397 LLKDAEALSQRLEEKAL 1413



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 58/310 (18%), Positives = 119/310 (38%), Gaps = 39/310 (12%)

Query: 215  ECKQRMLAREERHRRRMEEE------------RLRPPSPPPVVHYSDHECSIVAEKLKDD 262
            E K+++L   E   +R+EE+            RL+       V   DH+  + +   K  
Sbjct: 1392 EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQVASNLEKKQ 1450

Query: 263  SKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFK 322
             KF + +    +   R    R  A       ++    + R + E    +++ E   ++ +
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510

Query: 323  QALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRN-IHNDELMGIR 381
              +  ++   + +    H   K K      +A  + +     Q EE+ + +   E   +R
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSK------RALEQQVEEMRTQLEELEDELQATEDAKLR 1564

Query: 382  REEEMEMSDDEIEEMTETK----ETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQ 437
             E  M+    + E   +T+    E ++  L+ Q   L+ E +  R Q          L  
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ--------RALAV 1616

Query: 438  EQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQV----- 492
               K    D  + E Q++   +A   + + L K+Q + K  + ELE+ +  + ++     
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676

Query: 493  --EKMLENLK 500
              EK L++L+
Sbjct: 1677 ESEKKLKSLE 1686



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 46/209 (22%), Positives = 96/209 (45%), Gaps = 24/209 (11%)

Query: 301  RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS 360
            R L   +A+ ++   ++KE  K+  S   ++ E +      AS ++A  H  + +R  + 
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKS---LEAEILQLQEELASSERARRH-AEQERDEL- 1713

Query: 361  VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS 420
                 A+EI N  + +   +  +  +E    ++EE  E +++    L  +      + D+
Sbjct: 1714 -----ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768

Query: 421  LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA 480
            L  +L A R+  +     + ++ R+   NKE + KL  Q L+G       V+ ++K   A
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQ---NKELKAKL--QELEG------AVKSKFK---A 1814

Query: 481  ELEKLKDDKLQVEKMLENLKEKESCASRL 509
             +  L+    Q+E+ LE   ++ + A++L
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKL 1843


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 58/317 (18%), Positives = 138/317 (43%), Gaps = 7/317 (2%)

Query: 218 QRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIE 277
           +R+  REER ++R++E   R     P +  +D   S+ + ++++D+  +E  +       
Sbjct: 98  ERLARREERRQKRLQEALERQKEFDPTI--TDASLSLPSRRMQNDTAENETTEKEEKSES 155

Query: 278 RGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVA 337
           R E  R       ++ +S   +  R   E    +K+ EE +E+  +   G + + +  V 
Sbjct: 156 RQE--RYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEE--KPKRGSIGENQVEVM 211

Query: 338 VYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMT 397
           V    ++ +        +   IS    + EE R   +DE+    + EE +    E E   
Sbjct: 212 VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271

Query: 398 ETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLL 457
              E  E     Q + + +E   +  +  A   E E  + E+ +  RE++    ++ + +
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331

Query: 458 QQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSE 517
           ++  +   +   +++EE K+   E +++K+++ +  +  +  + +E   +++    ++ +
Sbjct: 332 KEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ 391

Query: 518 YPLEK-TMNSSPIKSER 533
              +K  M  + IK E+
Sbjct: 392 LEEKKHAMQETKIKGEK 408



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 58/315 (18%), Positives = 133/315 (42%), Gaps = 29/315 (9%)

Query: 223 REERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVN 282
           +E++ +   EEE+ +  S        +++  ++ E+   +S+    V +L    + G+++
Sbjct: 185 KEDKEKEEEEEEKPKRGS------IGENQVEVMVEEKTTESQEETVVMSL----KNGQIS 234

Query: 283 RRSANNFYSMIQSAN--SHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYH 340
                      Q ++  SH  ++  E    +K+  EA+    +A     I+ EQ   +  
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKMEEE----DKERAEAERARLEAEERERIKAEQDKKIAD 290

Query: 341 SASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETK 400
             ++ +A +     +R+      ++AEE   +  +E       + ++  +    E  +  
Sbjct: 291 ERARIEAEEKAAAQERER-----REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI 345

Query: 401 ETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQA 460
           + EE     + + +KEE      +    R E E    E+ KV   ++  + +QL+  + A
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEE----EKAKV---EEQKRNKQLEEKKHA 398

Query: 461 LQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPL 520
           +Q  +    KV+++ + K    +K ++DKLQ   + +  +EK +         Q+ +   
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF 458

Query: 521 EK-TMNSSPIKSERE 534
           +K  +    IK ++E
Sbjct: 459 KKEEIKDEKIKKDKE 473



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 83/406 (20%), Positives = 165/406 (40%), Gaps = 48/406 (11%)

Query: 185 RIRLGSSTDKK---DTGRLHVDFAQARDDLYEWECKQRMLAREER-----HRRRMEEERL 236
           R R+ +  DKK   +  R+  +   A  +    E ++R   REE       R+R++EE  
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEK 336

Query: 237 RPPSPPPVVHYSDHECSIVAEKLKDDSKFS--EAVQTLLTWIERGEVNRRSANNFYSMIQ 294
           R       +   +   +   +++K++ K +  E  +      E+ +V  +  N      +
Sbjct: 337 RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK 396

Query: 295 SANSHVR------------RLVNEKAAHEKDMEEAKEKFKQALSGILIQF--EQIVAVYH 340
            A    +            + VNEK A E  ++ A  K +    G  +Q   E++     
Sbjct: 397 HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456

Query: 341 SASKQKAWDHFTKAQR------KNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIE 394
           +  K++  D   K  +      K+     K   E+++ + + +    +  E   S     
Sbjct: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGR 516

Query: 395 EMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDD---PNKE 451
              +TKE E +    Q EA K   +  R + +    E E LKQ+Q +   E +     +E
Sbjct: 517 ASVDTKEAEGAP---QVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKRE 573

Query: 452 QQLKLLQQALQGMQQ----HLLKVQEEYKKKEAELEKLKDDKLQ-----VEKMLENLKEK 502
           ++ K+L++  Q  +Q      L+ +EE ++ + E+E+ + +  +      E  L + K+ 
Sbjct: 574 ERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 633

Query: 503 ESCASRLCAS---NQDSEYPLEKTMNSSPIKSEREALLVGIISTFL 545
             C +   +S    + +E+  +    SS +KS  +A +V  I + L
Sbjct: 634 FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRL 679


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 62/287 (21%), Positives = 126/287 (43%), Gaps = 29/287 (10%)

Query: 253  SIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEK 312
            S V+E LKD +   E +Q+L    +   + +    N    I   N     LV E  + + 
Sbjct: 2021 SDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN---QIAQLNKEKELLVKESESLQA 2077

Query: 313  DMEEA---KEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369
             + E+   K    +AL   L++  +  A+  S+++++        ++  + +   +A+E 
Sbjct: 2078 RLSESDYEKLNVSKALEAALVEKGEF-ALRLSSTQEEVHQLRRGIEKLRVRI---EADEK 2133

Query: 370  RNIHNDELMGIRREEEMEMSD--DEIEEMTETKETEESALVSQAEALKEENDSLRWQLDA 427
            + +H  E +  R  E   + D  + +E   +  E  +  ++  AE  K E ++L+ Q++ 
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193

Query: 428  YRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYK-----KKEAEL 482
                +++ + +   +  E    KE   K +Q+  QG    L K+   +K     K++AE+
Sbjct: 2194 MARSLKVFELDLVTLRSE----KENLTKQIQEK-QGQLSELDKLLSSFKSLLEEKEQAEI 2248

Query: 483  EKLKDDKLQVEKMLENLKEKESCASRLC-------ASNQDSEYPLEK 522
            +  ++ K  VE +   LKE     + LC       A+ Q  + P+E+
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 56/222 (25%), Positives = 96/222 (43%), Gaps = 19/222 (8%)

Query: 291  SMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDH 350
            S ++  NS    ++ EK   +  M+E      + L   L +  + VA  H+  +      
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEA----- 2463

Query: 351  FTKAQRKNIS--VWCKQAEEIRNIHN-DELMG--IRREEEMEMSDDEIEE---MTETKET 402
              KA+ +N+S  V C + E+ + +   DE     I  +  +     E+E+     E K+ 
Sbjct: 2464 -CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE 2522

Query: 403  EESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQ 462
            E S L +Q +    + + L  +L     E +L K EQ    R      EQ++++LQ    
Sbjct: 2523 EISRLKNQIQ----DQEQLVSKLSQVEGEHQLWK-EQNLELRNLTVELEQKIQVLQSKNA 2577

Query: 463  GMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKES 504
             +Q  L  +Q  YK  E ELE  K DK+   + +  +  KE+
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 41/164 (25%), Positives = 76/164 (46%), Gaps = 9/164 (5%)

Query: 380 IRREEEMEMSDDEIEEMT---ETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLK 436
           I +E+ +    DE+   T   +   T+ +AL  + + L E+    R   ++ R  +E   
Sbjct: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKI 389

Query: 437 QEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKK----EAELEKLKDDKLQV 492
           +E+ K  +E+   +++  + L Q    M+  L +  ++ K      +AEL+KL   K Q+
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449

Query: 493 EKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREAL 536
           E  LE  K+K   A +   ++Q  E  L ++M    +K E   L
Sbjct: 450 ENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE--MKKENNLL 491



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 13/139 (9%)

Query: 386 MEMSDDEIEEMTETKETEE-SALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHR 444
           M  + +E +E   T+  ++   L  Q + LK+E    ++QLD+   E  L KQ+Q KV  
Sbjct: 1   MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSL--EAALQKQKQ-KVEN 57

Query: 445 E--DDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELE----KLKDDKLQVEKMLEN 498
           E  +  N +++ + L +  + +++   K+  E + KE+++     +L   K Q+EK+ + 
Sbjct: 58  EKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117

Query: 499 LKEKESCASRLCASNQDSE 517
           LK    C S L  S Q ++
Sbjct: 118 LKR---CKSELERSQQAAQ 133



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 44/332 (13%)

Query: 200  LHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKL 259
            LH ++   RD L   + K   L   E H+R      L      P +H+S    +I+ E+ 
Sbjct: 756  LHAEYESLRDLL---KSKDASLVTNEDHQRS-----LLAFDQQPAMHHSF--ANIIGEQG 805

Query: 260  KDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKE 319
               S+ SE          R E ++   N+  +++Q+    +   +  +     D+++  E
Sbjct: 806  SMPSERSEC---------RLEADQSPKNS--AILQNRVDSLEFSLESQKQMNSDLQKQCE 854

Query: 320  KFKQALSGI---LIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDE 376
            +  Q    I   L++ EQ+   + + + Q+     +K Q    +     AE +  + N E
Sbjct: 855  ELVQIKGEIEENLMKAEQMHQSFVAETSQR----ISKLQEDTSAHQNVVAETLSALENKE 910

Query: 377  LMGIRREEEMEMSDDEIEEMTETKETEESALVSQ---AEALKEENDSLRWQLDAYRNEVE 433
                   +++E    EI+E+ ++    E +L      +E L  E   +   +   + E+E
Sbjct: 911  KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970

Query: 434  LLKQEQGKVHREDDPNKEQQLKLLQQA------LQGMQQHLLKVQEEYKKKE-------A 480
             L QE G +   +    ++++ L+Q++      +   ++ + ++ ++YK+++        
Sbjct: 971  ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE 1030

Query: 481  ELEKLKDDKLQVEKMLENLKEKESCASRLCAS 512
            E     +D  Q  K  +    K  C    C S
Sbjct: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 54/294 (18%), Positives = 119/294 (40%), Gaps = 43/294 (14%)

Query: 250  HECSIVAEKLKDDSK-----FSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLV 304
            +EC+ + E  K++ +     F++  Q  LT +   E   +   N    +++    +R  +
Sbjct: 1058 NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ---NLMLELETVQQALRSEM 1114

Query: 305  NEKAAHEKD-----------MEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTK 353
             +   + K            ++E + K ++ ++ +L + EQ++ V             TK
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK-----------TK 1163

Query: 354  AQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEA 413
             + +N+     ++E IRN   +      RE E    + + +   E KE    +  +Q   
Sbjct: 1164 HECQNL-----ESEPIRNSVKE------RESERNQCNFKPQMDLEVKEISLDSYNAQLVQ 1212

Query: 414  LKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQE 473
            L+    +   +L     E E L+ E   +  + + +  Q ++   Q + G++   +  +E
Sbjct: 1213 LEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQ--SQEISGLKDCEIDAEE 1270

Query: 474  EYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSS 527
            +Y     EL   ++D   ++  L+    K +   ++C   Q  +Y L   +N S
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDS 1324



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 27/136 (19%), Positives = 60/136 (44%), Gaps = 26/136 (19%)

Query: 391  DEIEEMTETKETEESALVSQAEALKEE----NDSLRWQLDAYRNEVELLKQEQGKVHRE- 445
            +E+E++ E  + E+  LV++    + E       +  ++    NEV++L  + G +H E 
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGEL 1360

Query: 446  ----------DDPNKEQQLKL-----------LQQALQGMQQHLLKVQEEYKKKEAELEK 484
                      + PN++  + L           L  + + +Q H  ++QE++   ++E + 
Sbjct: 1361 VEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKI 1420

Query: 485  LKDDKLQVEKMLENLK 500
            L D   Q+   +  L+
Sbjct: 1421 LHDQHCQMSSKMSELQ 1436



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 51/270 (18%), Positives = 118/270 (43%), Gaps = 26/270 (9%)

Query: 276  IERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGIL-IQFEQ 334
            +E  ++++ S     + + +  + ++R ++E A    +++E     K  L+G L +  E+
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEE 2656

Query: 335  IVA--------VYHSASKQKAWDHFTKAQ-------RKNISVWCKQAEEIRNIHNDELMG 379
            I +           ++  +K+ D   K Q       R+ I+ +  +  E    H   L+ 
Sbjct: 2657 IKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716

Query: 380  IRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQ 439
              ++ E+E+      E   +KE   S+   + + LK   + L   L A    +E LK+ +
Sbjct: 2717 TNKQYEVEIQT--YREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774

Query: 440  -------GKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQV 492
                    ++ +E++   + ++KLL ++ + +++    +Q+E  + +A  EK K   +  
Sbjct: 2775 MDNLKYVNQLKKENE-RAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD 2833

Query: 493  EKMLENLKEKESCASRLCASNQDSEYPLEK 522
             K+ E   E +     L    ++++  L+K
Sbjct: 2834 TKVDELTTEIKELKETLEEKTKEADEYLDK 2863



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 36/174 (20%), Positives = 77/174 (44%), Gaps = 42/174 (24%)

Query: 367  EEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEA----------LKE 416
            E +R +H  E     R+ ++E   +E++E+      +E  L+++ EA          LK+
Sbjct: 1782 ENLRLLHVIE----DRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKK 1837

Query: 417  ENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYK 476
            EN  L  +L+ +  + + L Q   +V   +  N + ++   + + + +  ++ KV + +K
Sbjct: 1838 ENSDLSEKLEYFSCDHQELLQ---RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWK 1894

Query: 477  KK-------------------------EAELEKLKDDKLQVEKMLENLKEKESC 505
            ++                         EA+LE ++ +KL +EK  EN ++   C
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVC 1948



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 39/234 (16%), Positives = 94/234 (40%), Gaps = 24/234 (10%)

Query: 282  NRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHS 341
            N+   +N    ++  ++   RL++     ++ +E    + K+  S + +Q  Q++    +
Sbjct: 1765 NQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA 1824

Query: 342  ASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKE 401
              + +      K +  ++S      E++     D    ++R E  E  + ++E   +   
Sbjct: 1825 CIELEKIVGELKKENSDLS------EKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS 1878

Query: 402  TEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHRED-----DPNKEQQLKL 456
             E+       + + + NDS + +     NE+  ++ E+  +  E      D    Q  KL
Sbjct: 1879 REDIG-----DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL 1933

Query: 457  L--------QQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEK 502
                     Q+ +  +++ L  V  E  +   EL+ +      ++++ E +KEK
Sbjct: 1934 CLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987



 Score = 29.6 bits (65), Expect = 8.5
 Identities = 19/62 (30%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 448 PNKEQQLKLLQQALQGMQQHL-LKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCA 506
           P+   QLK   Q L+     L L++Q   K+ + ++ K ++ +LQ+EK    L EKE   
Sbjct: 277 PHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336

Query: 507 SR 508
           ++
Sbjct: 337 NK 338


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 76/324 (23%), Positives = 143/324 (44%), Gaps = 54/324 (16%)

Query: 217  KQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSK--------FSEA 268
            KQ    + E  +R++EEE     +    +  S H+C ++ E+ +++ +         S+A
Sbjct: 1309 KQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKA 1368

Query: 269  VQTLLTW--------IERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEK 320
               +  W        I+R E    +       +Q A  HV   VN K A    +E+ K++
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV-EAVNAKCA---SLEKTKQR 1424

Query: 321  FKQALSGILIQFEQIVAVYHSA-SKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMG 379
             +  +  ++I  E+  A   +   KQ+ +D       K ++ W ++ EE     + EL  
Sbjct: 1425 LQNEVEDLMIDVERTNAACAALDKKQRNFD-------KILAEWKQKCEET----HAELEA 1473

Query: 380  IRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQ 439
             ++E     S     E+ + K   E +L  Q E LK EN +L+ ++     ++     E 
Sbjct: 1474 SQKE-----SRSLSTELFKIKNAYEESL-DQLETLKRENKNLQQEISDLTEQI----AEG 1523

Query: 440  GK-VHREDDPNK--EQQLKLLQQALQGMQQHL-------LKVQEEYKKKEAELE-KLKDD 488
            GK +H  +   K  EQ+   LQ AL+  +  L       L++Q E  + ++E++ K+ + 
Sbjct: 1524 GKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1583

Query: 489  KLQVEKMLEN-LKEKESCASRLCA 511
              ++++M  N ++  ES  S L A
Sbjct: 1584 DEEIDQMKRNHIRIVESMQSTLDA 1607



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/262 (19%), Positives = 116/262 (44%), Gaps = 25/262 (9%)

Query: 257  EKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEE 316
            E  K ++K  E  + ++T ++     +         +  A     +L+  K   E  ++E
Sbjct: 866  ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKE 925

Query: 317  AKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDE 376
              E+ +          E+ +    +A K+K  D  ++ ++    +    A+  +  H  E
Sbjct: 926  VTERAED---------EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976

Query: 377  LMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSL------RWQLDAYRN 430
                   EEM   D+ I ++T+ K+  + A     + L+ E D +      + +L+   +
Sbjct: 977  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1036

Query: 431  EVELLKQEQGKVHREDDPNK---EQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL----E 483
            ++E   +++ K+  + +  K   E  LKL Q++   ++    ++ E+ KKKE E+     
Sbjct: 1037 DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS 1096

Query: 484  KLKDDK---LQVEKMLENLKEK 502
            K++D++   +Q++K ++ L+ +
Sbjct: 1097 KIEDEQALGMQLQKKIKELQAR 1118



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 45/233 (19%), Positives = 88/233 (37%), Gaps = 19/233 (8%)

Query: 355  QRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEAL 414
            ++K+     +  E+I N+   +    + + EM+M  D++    ET    +  L     AL
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRAL 1256

Query: 415  ----------KEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGM 464
                      +EE   L   L A R  ++    E  +   E D    Q  +  Q   Q +
Sbjct: 1257 EDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQI 1316

Query: 465  QQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRL--CASNQDSE----- 517
            ++   +++EE K K A    L+  +   + + E  +E++   + L    S  +SE     
Sbjct: 1317 EELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWR 1376

Query: 518  --YPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKI 568
              Y  +    +  ++  ++ L   +     HV    A    +     RL N++
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 42/200 (21%), Positives = 82/200 (41%), Gaps = 18/200 (9%)

Query: 311  EKDMEEAKEKFKQA---LSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAE 367
            E D ++  EK K+    +SG+  + E   A+     K+           K +    ++ E
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKI----------KELQARIEELE 1123

Query: 368  EIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKE---ENDSLRWQ 424
            E   I  +     + E++      E+EE++E  E    A  +Q E  K+   E   +R  
Sbjct: 1124 E--EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181

Query: 425  LDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEK 484
            L+    + E       K H +      +Q+  LQ+  Q +++   +++ E     + +E 
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241

Query: 485  LKDDKLQVEKMLENLKEKES 504
            +   K  +EKM   L+++ S
Sbjct: 1242 VSKAKGNLEKMCRALEDQLS 1261



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 34/148 (22%), Positives = 68/148 (45%), Gaps = 22/148 (14%)

Query: 366  AEEIRNIH--NDELMGIRREEEMEMS------DDEIEEMTETKETEESALVS---QAEAL 414
            +E ++ +H  N  L+  +++ E ++S      +D I+E    +E  + A+      AE L
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773

Query: 415  KEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEE 474
            K+E D+        +N  + +K  Q   HR D+          Q AL+G ++ + K++  
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKDLQ---HRLDEAE--------QLALKGGKKQIQKLEAR 1822

Query: 475  YKKKEAELEKLKDDKLQVEKMLENLKEK 502
             ++ E E+E  +   ++  K L   + K
Sbjct: 1823 VRELEGEVESEQKRNVEAVKGLRKHERK 1850


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 62/258 (24%), Positives = 117/258 (45%), Gaps = 27/258 (10%)

Query: 249 DHECSIVA---EKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVN 305
           D +CS V    ++L++  +  EA Q     + R +V          +       +R+++ 
Sbjct: 529 DPKCSFVEKERQRLENLRRKEEAEQ-----LRRQKVEEDKRRRLEEVKLKREERLRKVLQ 583

Query: 306 EKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQ 365
            +   E+  EE K++ +Q  + I  + E+  A     +++KA       + + +    KQ
Sbjct: 584 ARERVEQMKEEKKKQIEQKFAQIDEKTEK--AKEERLAEEKAKKKAAAKKMEEVEARRKQ 641

Query: 366 AEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQL 425
            EE R      L  +++EEE        E + + KE E+  L   AEA +     L  Q 
Sbjct: 642 EEEAR-----RLRWLQQEEEERRHQ---ELLQKKKEEEQERLRKAAEAKR-----LAEQR 688

Query: 426 DAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKL 485
           +  R E E  +QE+ +  R +   +EQ+ +L +Q  +  +Q  L+ + E +++E  L   
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQE-RRREQERLQAERELQEREKALRLQ 747

Query: 486 KDDKLQVEKMLENLKEKE 503
           K+   Q+++ LE  K+KE
Sbjct: 748 KE---QLQRELEEKKKKE 762



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 53/253 (20%), Positives = 99/253 (39%), Gaps = 17/253 (6%)

Query: 223 REERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVN 282
           R E  RR+ E E+LR           D    +   KLK + +  + +Q      +  E  
Sbjct: 541 RLENLRRKEEAEQLRRQKVE-----EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595

Query: 283 RRSANNFYSMIQSANSHVR--RLVNEKA---AHEKDMEEAKEKFKQALSGILIQFEQIVA 337
           ++     ++ I       +  RL  EKA   A  K MEE + + KQ      +++ Q   
Sbjct: 596 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ--- 652

Query: 338 VYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMT 397
                 +++      + +++      ++A E + +        R +E  E    E E   
Sbjct: 653 ---QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709

Query: 398 ETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLL 457
           + +  +E  L  Q    ++E      +L   R +   L++EQ +   E+   KE+Q +L 
Sbjct: 710 QERREQERQLAEQERRREQERLQAERELQE-REKALRLQKEQLQRELEEKKKKEEQQRLA 768

Query: 458 QQALQGMQQHLLK 470
           ++ LQ  Q+   K
Sbjct: 769 ERQLQEEQEKKAK 781



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 45/225 (20%), Positives = 86/225 (38%), Gaps = 38/225 (16%)

Query: 141 EQIIVEVFEQCGEIIAIRKSKKNFCHIRFAE-EYMVDKALYLSGYRIRLGSSTDKKDTGR 199
           E+ + +V +    +  +++ KK     +FA+ +   +KA        RL     KK    
Sbjct: 575 EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK-----EERLAEEKAKKKAAA 629

Query: 200 LHVDFAQARDDLYEWECKQRMLAREERHRRRM---------EEERLRPPSPPPVVHYSDH 250
             ++  +AR    E   + R L +EE  RR           E+ERLR  +          
Sbjct: 630 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAA---------- 679

Query: 251 ECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAH 310
           E   +AE+ + + +  E  +      ER E  RR         Q      R+L  ++   
Sbjct: 680 EAKRLAEQREQERREQERREQ-----ERREQERRE--------QERREQERQLAEQERRR 726

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQ 355
           E++  +A+ + ++    + +Q EQ+        K++      + Q
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 771


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 63/310 (20%), Positives = 144/310 (46%), Gaps = 29/310 (9%)

Query: 214 WECKQRMLAREERHRRRMEE-ERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTL 272
           WE  +R+  +EER R + +  E++        +   + +     EK++++ +  E  + +
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459

Query: 273 L----TWIERGEVNRRSANNFYSMIQSANSHVRRLVN--EKAAHEKDMEEAKEKFKQALS 326
                T  E+ E  ++   N +   +      +RL    EK   ++ M+E +EK  +   
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQ-EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518

Query: 327 GILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHN-----DELMGIR 381
            I  Q E          ++K W    K + +   +W +Q E++R+        +E M  +
Sbjct: 519 KIRDQEEMW------GQEKKMWRQ-EKMREQEDQMW-EQEEKMRDQEQKMWDQEERMEKK 570

Query: 382 REEEMEMSDDEIEEMTETKETEE--SALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQ 439
            +E+ + + D+ E+M E +   E    +  + E ++E+ + ++ Q +  + + E + +++
Sbjct: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE 630

Query: 440 GKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEE---YKKKEAELEKLKDDKLQV---E 493
            K+  +++   EQ+ K+ +Q  +  +Q  L  Q+E     +K  E EK+++ + ++   E
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690

Query: 494 KMLENLKEKE 503
           KM +  +E+E
Sbjct: 691 KMEKKTQEQE 700



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 36/144 (25%), Positives = 77/144 (53%), Gaps = 13/144 (9%)

Query: 364 KQAEEIRN----IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEEND 419
           +Q EE+R     I   E    R+EE +   + ++ E  E    +E  L  Q + L+E+  
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335

Query: 420 SLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE 479
            LR Q +    E ++ +QE+ K+  +++  +EQ+ K+ +Q     ++ L + +++ +++E
Sbjct: 336 ELREQKELREQEEQMQEQEE-KMWEQEEKMREQEEKMWRQ-----EERLWEQEKQMREQE 389

Query: 480 AELEKLKDDKLQVEKMLENLKEKE 503
              +K++D + ++ +  E L+EKE
Sbjct: 390 ---QKMRDQEERMWEQDERLREKE 410



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 44/212 (20%), Positives = 103/212 (48%), Gaps = 25/212 (11%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQA--EE 368
           E+ M+E +EK ++    +  Q E++        ++K W+   K   +   +W +Q   E+
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKM-----QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663

Query: 369 IRNIHNDELMG----IRREEEMEMSDDEIEEMTETKE--TEESALVSQAEALKEENDSLR 422
              +   E M     ++ +EE     +++E+ T+ +E  T +   + + E+++E    +R
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723

Query: 423 WQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLL-----------KV 471
            + +  R + E +++++ K+  +++   EQ+ K+ +Q  +  +Q  L           K+
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783

Query: 472 QEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           QE+ K  E E EK++D + ++    E ++ +E
Sbjct: 784 QEQEKIWEQE-EKMRDQEEKMRGQEEKMRGQE 814



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 49/224 (21%), Positives = 101/224 (45%), Gaps = 17/224 (7%)

Query: 303 LVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ--KAW--DHFTKAQRKN 358
           L  E    E+++ E ++K ++    +  Q E++        +Q  K W  +   + Q K 
Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329

Query: 359 ISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEEN 418
           +    K+  E + +   E     +EE+M   ++++ E  E    +E  L  Q + ++E+ 
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389

Query: 419 DSLR------WQLDAYRNEVELLKQEQGKVH------REDDPNKEQQLKLLQQALQGMQQ 466
             +R      W+ D    E E   +EQ K+       RE+   +EQ+ K   Q  +  ++
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449

Query: 467 HLLKVQEEYKKKEAELEKLKDDKLQV-EKMLENLKEKESCASRL 509
             ++ +E+  ++E E  + +++K+Q  E+ +   +EKE    RL
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 43/197 (21%), Positives = 90/197 (45%), Gaps = 13/197 (6%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ-KAWDHFTKAQRKNISVWCKQAEEI 369
           EK M E ++K +     +  Q E++        +Q K W+   K + +      K+ +E 
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE------KKMQEQ 435

Query: 370 RNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYR 429
                D+   ++ EE +   + ++ E  ET   +E  +  Q E + E+ +   WQ     
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK-EWQQQRLP 494

Query: 430 NEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL----EKL 485
            + E L  EQ K+  +++   EQ+ K+  Q     Q+  +  QE+ +++E ++    EK+
Sbjct: 495 EQKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553

Query: 486 KDDKLQVEKMLENLKEK 502
           +D + ++    E +++K
Sbjct: 554 RDQEQKMWDQEERMEKK 570



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 66/329 (20%), Positives = 142/329 (43%), Gaps = 54/329 (16%)

Query: 214 WECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLL 273
           WE +++M  R++  +   +EER+   +        D E     EK++++ +  E  + + 
Sbjct: 547 WEQEEKM--RDQEQKMWDQEERMEKKTQEQEKKTWDQE-----EKMREEERMREREKKMR 599

Query: 274 TWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFE 333
              E  E+ R          +       ++  +    E+ M+E +EK  +    +  Q E
Sbjct: 600 ---EEEEMMREQEEKMQEQEEKMQEQEEKMWEQ----EEKMQEQEEKMWEQEEKMWEQEE 652

Query: 334 QIVAVYH-SASKQKAWDHFT-----KAQRKNISVW------CKQAEEIRNIHNDELMG-- 379
           ++         K+K W+H       K Q +   +W       K  E+ +   + E M   
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712

Query: 380 ---------IRREEEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYR 429
                    +R EEEM    +E ++E  E  + +E  +  Q E + E+ + + W+     
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLP 771

Query: 430 NEVELL-----KQEQGKVHREDDPNKEQQLKL--LQQALQGMQQHLLKVQEEYKKKEAEL 482
            + E L      QEQ K+  +++  ++Q+ K+   ++ ++G ++ +   +E+   +E ++
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831

Query: 483 ----EKL--KDDKL--QVEKMLENLKEKE 503
               EK+  +++K+  Q EKM E ++ +E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQE 860



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 57/304 (18%), Positives = 126/304 (41%), Gaps = 18/304 (5%)

Query: 214 WECKQRMLAREERHRRRME-----EERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEA 268
           W  ++R+  +E + R + E     E+RLR       +   + E     E  + + +  E 
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKE--LREQEKELREQKELREQEEQMQEQ 353

Query: 269 VQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGI 328
            + +    E+              +      +R    +    E+ M E  E+ ++    +
Sbjct: 354 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413

Query: 329 LIQ---FEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE 385
             Q   +EQ+  +     K +  +  T+ Q + +    +  E  + +  +E     +EE+
Sbjct: 414 REQEKMWEQVEKM-REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK 472

Query: 386 MEMSDDEIEEMTETKETEESALVSQAEAL------KEENDSLRWQLDAYRNEVELLKQEQ 439
           M+  ++ + E  E KE ++  L  Q E L      +E+ + +  Q +  R++ E+  QE+
Sbjct: 473 MQKQEENMWEQEE-KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 531

Query: 440 GKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENL 499
               +E    +E Q+   ++ ++  +Q +   +E  +KK  E EK   D+ +  +  E +
Sbjct: 532 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM 591

Query: 500 KEKE 503
           +E+E
Sbjct: 592 RERE 595



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/208 (22%), Positives = 96/208 (46%), Gaps = 21/208 (10%)

Query: 305 NEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCK 364
           +EK+  + +++E K K ++A   +L Q +          +++      K  RK      +
Sbjct: 239 SEKSEIQLNVKELKRKLERA-KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297

Query: 365 QAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQ 424
           Q E +R     E  G  RE+E +M   E     + KE  E     Q + L+E+ + LR Q
Sbjct: 298 QEERLR-----EQEGKMREQEEKMWRQEKRLREQEKELRE-----QEKELREQKE-LREQ 346

Query: 425 LDAYRNEVELLKQEQGKVHREDDP---------NKEQQLKLLQQALQGMQQHLLKVQEEY 475
            +  + + E + +++ K+  +++           +E+Q++  +Q ++  ++ + +  E  
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406

Query: 476 KKKEAELEKLKDDKLQVEKMLENLKEKE 503
           ++KE  + + +    QVEKM E  K +E
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQE 434



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/132 (24%), Positives = 70/132 (53%), Gaps = 18/132 (13%)

Query: 384 EEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRW----------QLDAYRNEVE 433
           EE++  + E++E     E+E+S +    + LK + +  ++          Q + +R E E
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280

Query: 434 LLKQE------QGKVHREDDPNKEQQLKLLQQ--ALQGMQQHLLKVQEEYKKKEAELEKL 485
           L +QE      + K+ R+++  +EQ+ K+ +Q   +   ++ L + ++E +++E EL + 
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ 340

Query: 486 KDDKLQVEKMLE 497
           K+ + Q E+M E
Sbjct: 341 KELREQEEQMQE 352



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 54/316 (17%), Positives = 135/316 (42%), Gaps = 39/316 (12%)

Query: 214 WECKQRMLARE---ERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQ 270
           W+ +++M   E   ER ++  EEE +       +    +       +  + + K  E  +
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638

Query: 271 TLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILI 330
            +  W E+ E         +   +      +   +EK   ++ M+E +EK  +       
Sbjct: 639 KM--W-EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE------- 688

Query: 331 QFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEM---- 386
             ++ +       ++K WD     + +++    K+  E   +  ++   ++ +EE     
Sbjct: 689 --QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746

Query: 387 --EMSDDEIEEMTETKET--EESALVSQAEALKE-----ENDSLRWQLDAYRNEVELLKQ 437
             EM + E E+M E +E   E+  L  Q E L E     E + +  Q +  R++ E ++ 
Sbjct: 747 EEEMWEQE-EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805

Query: 438 EQGKVHREDDPNKEQQLKL---------LQQALQGMQQHLLKVQEEYKKK-EAELEKLKD 487
           ++ K+  +++  + Q+ K+          ++ + G ++ +   +E+ ++K + + EK+++
Sbjct: 806 QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865

Query: 488 DKLQVEKMLENLKEKE 503
            + ++    E ++E+E
Sbjct: 866 QEEKMRGQEEKMREQE 881


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 40/211 (18%), Positives = 104/211 (49%), Gaps = 18/211 (8%)

Query: 293 IQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFT 352
           +Q     V++   +    E+ M E +E+ ++    +L Q EQ      +  +++      
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302

Query: 353 KAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAE 412
           +  R+      +Q E++R    +E MG ++EE+M    +++ E  E    +E  +  Q E
Sbjct: 303 EQMREQEEQMREQEEQMRE--QEEQMG-KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEE 359

Query: 413 ALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQ 472
            ++++ + +R Q +  R + E +++++ ++ ++++   EQ+ ++ +Q            +
Sbjct: 360 QMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ------------K 407

Query: 473 EEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           E+ +++E   E++ + K Q+ K  E++ E++
Sbjct: 408 EQMREQE---EQMGEQKEQMRKQEEHMGEQK 435



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 28/140 (20%), Positives = 79/140 (56%), Gaps = 4/140 (2%)

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRW 423
           +Q E+++    +E MG  +EE+M   ++++ E  E  + +E  +  Q E ++++ + +R 
Sbjct: 210 EQEEQMQK--QEEQMG-EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266

Query: 424 QLDAYRNEVE-LLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL 482
           Q +  R + E +LKQ++     E    +E+Q++  ++ ++  ++ + + +E+ +++E ++
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326

Query: 483 EKLKDDKLQVEKMLENLKEK 502
            K ++   + ++ +   KE+
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQ 346



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 44/194 (22%), Positives = 95/194 (48%), Gaps = 13/194 (6%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIR 370
           E+ M++ +E+  +    +  Q EQ+        KQ+      + Q +      KQ E++R
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR------KQEEQMR 265

Query: 371 NIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRN 430
               +E M  R +EE  +   E  E  E    +E  +  Q E ++E+ + +R Q +  R 
Sbjct: 266 --EQEEQM--REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE 321

Query: 431 EVELLKQEQGKVHREDDPNKEQQLKLLQQALQ-GMQQHLLKVQEEYKKKEAELEKLKDDK 489
           + E + +++ ++  + +   EQ+ ++ +Q  Q G Q+  ++ QEE  +K+   E+++  +
Sbjct: 322 QEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE--EQMRKQE 379

Query: 490 LQVEKMLENLKEKE 503
            Q+ K  E ++++E
Sbjct: 380 EQMRKQEEQMRKQE 393



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 24/122 (19%), Positives = 71/122 (58%), Gaps = 2/122 (1%)

Query: 382 REEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGK 441
           +EE+M   ++++++  E    +E  +  Q E + E+ + ++ Q +  + + E +++++ +
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ 263

Query: 442 VHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE 501
           +  +++  +EQ+ ++L+Q  Q  Q+     QEE  +++   E++++ + Q+ +  E ++E
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE--EQMREQEEQMREQEEQMRE 321

Query: 502 KE 503
           +E
Sbjct: 322 QE 323



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 39/219 (17%), Positives = 97/219 (44%), Gaps = 27/219 (12%)

Query: 293 IQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFT 352
           ++     VR    +    E  M E +E+  +    +  Q EQ+        KQ+      
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE----- 234

Query: 353 KAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAE 412
                      +  E+   +   E    ++EE+M   ++++ E  E    +E  ++ Q E
Sbjct: 235 -----------QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKE 283

Query: 413 ALK------EENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQ 466
             +      E+ + +R Q +  R + E +++++ ++  +++   +Q+ ++ +Q  Q  +Q
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343

Query: 467 --HLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
              + K +E+  ++E +++K ++   QV K  E ++++E
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEE---QVRKQEEQMRKQE 379



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 35/198 (17%), Positives = 93/198 (46%), Gaps = 6/198 (3%)

Query: 311 EKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ----KAWDHFTKAQRKNISVWCKQA 366
           E+ M + +E+  +    +  Q EQ+        KQ    +  +   + Q + +    +Q 
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQT 285

Query: 367 EEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLD 426
           E+       E     +EE+M   ++++ E  E    +E  +  Q E + E+ + +  Q +
Sbjct: 286 EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKE 345

Query: 427 A-YRNEVELLKQEQGKVHREDDPNK-EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEK 484
             ++ E ++ +QE+    +E+   K E+Q++  ++ ++  ++ + K +E+  +++ ++ +
Sbjct: 346 QMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGE 405

Query: 485 LKDDKLQVEKMLENLKEK 502
            K+   + E+ +   KE+
Sbjct: 406 QKEQMREQEEQMGEQKEQ 423



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 40/204 (19%), Positives = 97/204 (47%), Gaps = 18/204 (8%)

Query: 300 VRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNI 359
           +R+   +    E+ +++ +E+ ++    +  Q EQ+        +Q+      K Q +  
Sbjct: 229 MRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE 288

Query: 360 SVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEEND 419
               +Q E++R    +E M   +EE+M   ++++ E  E    +E  +  Q E + E+ +
Sbjct: 289 EQTGEQEEQMRE--QEEQMR-EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKE 345

Query: 420 SLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKE 479
            + W+ +    E E   Q+Q           E+Q++  ++ ++  ++ + K +E+ +K+E
Sbjct: 346 QM-WKQEEQMGEQEEQMQKQ-----------EEQVRKQEEQMRKQEEQMRKQEEQMRKQE 393

Query: 480 AELEKLKDDKLQVEKMLENLKEKE 503
              E++ + K Q+ +  E ++E+E
Sbjct: 394 ---EQMGEQKEQMGEQKEQMREQE 414



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 26/136 (19%), Positives = 72/136 (52%), Gaps = 8/136 (5%)

Query: 376 ELMGIRREEEMEMSDDE--IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVE 433
           E  G  RE+E ++ + E  + E       +E  +  Q   ++E+   +R Q    R +  
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185

Query: 434 LLKQEQGKVHREDDP--NKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAEL----EKLKD 487
            +++++G++  ++     +E+Q+   ++ +Q  ++ + + +E+ +K+E ++    E+++ 
Sbjct: 186 QVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK 245

Query: 488 DKLQVEKMLENLKEKE 503
            + QV+K  E ++++E
Sbjct: 246 QEEQVQKQEEQMRKQE 261



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 34/157 (21%), Positives = 72/157 (45%), Gaps = 12/157 (7%)

Query: 376 ELMGIRREEEMEMSDDE--IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVE 433
           E  G  RE+E ++ + E  + E       +E  +  Q   ++E+   +R Q    R +  
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164

Query: 434 LLKQEQGKVHREDDPNKEQQLKLLQQALQ--------GMQQHLLKVQEEYKKKEAELEKL 485
            +++++G+V  ++   +EQ+ ++ +Q  Q        G Q+  +  QEE  +K+   E++
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE--EQM 222

Query: 486 KDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEK 522
            + + Q+ K  E + E+E    +     Q  E  + K
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK 259



 Score = 37.4 bits (85), Expect = 0.041
 Identities = 32/151 (21%), Positives = 73/151 (48%), Gaps = 9/151 (5%)

Query: 376 ELMGIRREEEMEMSDDE--IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVE 433
           E  G  RE+E ++ + E  + E       +E  +  Q   ++E+   +  Q      + E
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEE 206

Query: 434 LLKQEQGKVHREDDPNKEQQLKLLQQALQ-GMQQHLLKVQEEYKKKEAELEKLKDDKL-- 490
            + +++ ++ ++++   EQ+ ++ +Q  Q G Q+  ++ QEE  +K+ E  + +++++  
Sbjct: 207 QMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266

Query: 491 QVEKMLEN----LKEKESCASRLCASNQDSE 517
           Q E+M E     LK+KE          Q+ +
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 28/123 (22%), Positives = 66/123 (53%), Gaps = 4/123 (3%)

Query: 384 EEMEMSDDEIEEMTETKETEESALVSQAEALKE--ENDSLRWQLDAYRNEVE-LLKQEQG 440
           EE++  + E++E  +  ETE+S +    + LK   E D +    +    E E  +++++G
Sbjct: 7   EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66

Query: 441 KVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLK 500
           +V  ++   +EQ+ ++ +Q  Q  +Q     ++E + +E E  ++++ + QV +    ++
Sbjct: 67  QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-GQVREQEGQVREQEGQVR 125

Query: 501 EKE 503
           E+E
Sbjct: 126 EQE 128



 Score = 36.2 bits (82), Expect = 0.090
 Identities = 29/136 (21%), Positives = 66/136 (48%), Gaps = 8/136 (5%)

Query: 376 ELMGIRREEEMEMSDDE--IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVE 433
           E  G  RE+E ++ + E  + E       +E  +  Q   ++E+   +R Q    R +  
Sbjct: 91  EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 150

Query: 434 LLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAE------LEKLKD 487
            +++++G+V  ++   +EQ+ ++ +Q  Q  +Q     ++E +  E E       E++ +
Sbjct: 151 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGE 210

Query: 488 DKLQVEKMLENLKEKE 503
            + Q++K  E + E+E
Sbjct: 211 QEEQMQKQEEQMGEQE 226



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 26/151 (17%), Positives = 76/151 (50%), Gaps = 4/151 (2%)

Query: 353 KAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAE 412
           + ++  I +  K+ +  R +  D++  + +E ++   + ++ E       +E  +  Q  
Sbjct: 24  ETEKSEIQLHIKELK--RKLETDKIP-LPQEGQVREQEGQVREQEGQVREQEGQVREQEG 80

Query: 413 ALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQ 472
            ++E+   +R Q    R +   +++++G+V  ++   +EQ+ ++ +Q  Q  +Q     +
Sbjct: 81  QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 140

Query: 473 EEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           +E + +E E  ++++ + QV +    ++E+E
Sbjct: 141 QEGQVREQE-GQVREQEGQVREQEGQVREQE 170



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 27/130 (20%), Positives = 65/130 (50%), Gaps = 3/130 (2%)

Query: 376 ELMGIRREEEMEMSDDE--IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVE 433
           E  G  RE+E ++ + E  + E       +E  +  Q   ++E+   +R Q    R +  
Sbjct: 70  EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129

Query: 434 LLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVE 493
            +++++G+V  ++   +EQ+ ++ +Q  Q  +Q     ++E + +E E  ++++ + QV 
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-GQVREQEGQVR 188

Query: 494 KMLENLKEKE 503
           +    + E+E
Sbjct: 189 EQEGQMGEQE 198


>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 51/241 (21%), Positives = 106/241 (43%), Gaps = 15/241 (6%)

Query: 303  LVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKA-----WDHFTKAQRK 357
            L+++    EK ++E + K     S +      +  V HSA K+ +     +  F   Q K
Sbjct: 775  LLSQLNVLEKQLQETQTKNDFLKSEV----HDLRVVLHSADKELSSVKLEYSSFKTNQEK 830

Query: 358  NISVWCKQAEEIR-NIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKE 416
              +   ++   ++  + N  L   +  E      D  + + E  + E   L    +  K+
Sbjct: 831  EFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKK 890

Query: 417  ENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYK 476
            EN++L+  L+     +E  K+   K+  + + +KE   K + + L+ ++Q   K   + +
Sbjct: 891  ENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCE 950

Query: 477  KKEAELEKLKDDKLQVEKMLENLKEKESCASRLCAS--NQDSEY---PLEKTMNSSPIKS 531
            ++ A+++KL++  L  EK++ +L++      ++ A   NQ  E      EKT     +K 
Sbjct: 951  QQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQ 1010

Query: 532  E 532
            E
Sbjct: 1011 E 1011



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 32/124 (25%), Positives = 62/124 (50%), Gaps = 11/124 (8%)

Query: 367  EEIRN-IHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQL 425
            EE+++ ++N E+  +R  +E+E +     +  + KE     L S+ E + EE +    ++
Sbjct: 1271 EEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQ----LRSKLEEMYEERERTSQEM 1326

Query: 426  DAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKL 485
            +  R +VE L +E GK+         Q L    Q +  +++  +++ EE +K  AE   L
Sbjct: 1327 EMLRKQVECLAEENGKL------VGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL 1380

Query: 486  KDDK 489
            K+ K
Sbjct: 1381 KEKK 1384



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 57/272 (20%), Positives = 114/272 (41%), Gaps = 17/272 (6%)

Query: 257  EKLKDDSKFS--EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDM 314
            + L++  KF   +  + L  + +  E  +   NN   ++++      +L       E+D 
Sbjct: 868  DNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKL---SLQFEEDK 924

Query: 315  EEAKEKFKQALSGILIQFEQIVA-VYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIH 373
            E + ++  + L  +  + ++  A      +K +  +    A  K IS   K  +  + + 
Sbjct: 925  ENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVV 984

Query: 374  NDELMGIRRE-----EEMEMSDDEIEEMTETKETEESALVSQAEAL----KEENDSLRWQ 424
             D +  I+       E+ E  D   +E+ +      SALV + E+     K+E D L  +
Sbjct: 985  ADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLK 1044

Query: 425  LDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEK 484
             +  R  + L +  +  +  ED  +  +QL +L +A +     L   QEE  KKEA +++
Sbjct: 1045 -ETLRLRI-LSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQE 1102

Query: 485  LKDDKLQVEKMLENLKEKESCASRLCASNQDS 516
            L+    Q ++ +E  K + +   R      DS
Sbjct: 1103 LQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDS 1134


>gi|113425145 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 2 isoform 3 [Homo sapiens]
          Length = 632

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 62/291 (21%), Positives = 133/291 (45%), Gaps = 30/291 (10%)

Query: 245 VHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANS-HVRRL 303
           + Y + E   +A +L+   +    +++ L+ +   E  ++ AN   S  ++     + + 
Sbjct: 156 LRYFEEESKDLAVRLQHSLQCKGELESALSAVIATE--KKKANQLSSCSKAHTEWELEQS 213

Query: 304 VNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWC 363
           + ++A  +  + + KE F+Q      +Q E+     H   ++  W      QR +     
Sbjct: 214 LQDQALLKAQLTQLKESFQQ------LQLERDECAEHIEGERARWH-----QRMS----- 257

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIE-EMTETKETEESALVSQAEA--LKEENDS 420
           K ++EI  +  ++   +RR EE+E S  +++ +M E    E  A+ S+ E   L++E + 
Sbjct: 258 KMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELER 317

Query: 421 LRWQLDAY---RNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKK 477
           +  +L +       + LL + Q +  RE +    +Q + LQ+  + ++Q L K Q  ++ 
Sbjct: 318 VAGELQSQVKNNQHISLLNRRQEERIREQEERLRKQEERLQEQHEKLRQ-LAKPQSVFE- 375

Query: 478 KEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSP 528
              EL       LQ+E+ ++ L+EK        AS Q+ +   + ++ + P
Sbjct: 376 ---ELNNENKSTLQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALP 423


>gi|113425137 PREDICTED: similar to Golgin subfamily A member 8-like
           protein 2 isoform 3 [Homo sapiens]
          Length = 632

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 62/291 (21%), Positives = 133/291 (45%), Gaps = 30/291 (10%)

Query: 245 VHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANS-HVRRL 303
           + Y + E   +A +L+   +    +++ L+ +   E  ++ AN   S  ++     + + 
Sbjct: 156 LRYFEEESKDLAVRLQHSLQCKGELESALSAVIATE--KKKANQLSSCSKAHTEWELEQS 213

Query: 304 VNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWC 363
           + ++A  +  + + KE F+Q      +Q E+     H   ++  W      QR +     
Sbjct: 214 LQDQALLKAQLTQLKESFQQ------LQLERDECAEHIEGERARWH-----QRMS----- 257

Query: 364 KQAEEIRNIHNDELMGIRREEEMEMSDDEIE-EMTETKETEESALVSQAEA--LKEENDS 420
           K ++EI  +  ++   +RR EE+E S  +++ +M E    E  A+ S+ E   L++E + 
Sbjct: 258 KMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELER 317

Query: 421 LRWQLDAY---RNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKK 477
           +  +L +       + LL + Q +  RE +    +Q + LQ+  + ++Q L K Q  ++ 
Sbjct: 318 VAGELQSQVKNNQHISLLNRRQEERIREQEERLRKQEERLQEQHEKLRQ-LAKPQSVFE- 375

Query: 478 KEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSP 528
              EL       LQ+E+ ++ L+EK        AS Q+ +   + ++ + P
Sbjct: 376 ---ELNNENKSTLQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMALP 423


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 65/307 (21%), Positives = 124/307 (40%), Gaps = 38/307 (12%)

Query: 217 KQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWI 276
           +++ L RE++ RR  EEER          H   HE     ++LK + +          W+
Sbjct: 415 REQQLRREQQLRREQEEER----------HEQKHEQERREQRLKREQEERR------DWL 458

Query: 277 ERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIV 336
           +R E   R            +    R        E++  E +E+ +Q L     + EQ  
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL-----RREQEE 513

Query: 337 AVYHSASKQKAWDHFTKAQRKNISVWCKQAEE----IRNIHNDELMGIRREEEMEMSDDE 392
                  +Q+  +   +  R    +  +Q E     ++      L   RRE+ ++   +E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573

Query: 393 IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHR----EDDP 448
             +    +E E      Q    +E+ + L  +L   R EVE L+QE+ +  R    E + 
Sbjct: 574 RRDQLLKREEERR----QQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPEE 627

Query: 449 NKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASR 508
            + QQL   ++  +  QQ L + Q+E +++     K ++++ ++E+ L+   E+E     
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRL---KREEEEERLEQRLKREHEEERREQE 684

Query: 509 LCASNQD 515
           L    Q+
Sbjct: 685 LAEEEQE 691



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 68/334 (20%), Positives = 130/334 (38%), Gaps = 22/334 (6%)

Query: 206 QARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKF 265
           + R +  E E +Q+ L RE++ RR+ EEER                     E+ +   + 
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE----------------ERREQQERR 328

Query: 266 SEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDM--EEAKEKFKQ 323
            +  +     + R +  RR         +       R   E+   E+ +  E+   + +Q
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388

Query: 324 ALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRRE 383
                 ++ EQ +       +++      + +R+      ++ E     H  E    R +
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448

Query: 384 EEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVH 443
            E E   D ++   ET+  E+     Q +  +EE    RW         E  ++ + ++ 
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508

Query: 444 REDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
           RE +  +EQ+LK  Q+  + +QQ L   Q+  +++E   E+L   K + EK LE  + +E
Sbjct: 509 REQEERREQRLK-RQEEEERLQQRLRSEQQLRREQEERREQLL--KREEEKRLEQ-ERRE 564

Query: 504 SCASRLCASNQDSEYPLEKTMNSSPIKSEREALL 537
               R     +D     E+      +K E+E  L
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERL 598



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 64/358 (17%), Positives = 151/358 (42%), Gaps = 57/358 (15%)

Query: 193  DKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHEC 252
            D+K   +L  +  + R  LY     Q  L +E++  +  EEE  R           + + 
Sbjct: 871  DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ- 929

Query: 253  SIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEK 312
                   +++ +  +  + LL   ER +  R+     Y   +       +L+ E+   EK
Sbjct: 930  ------YREEEQLQQEEEQLLR-EEREKRRRQERERQYRKDKKLQQKEEQLLGEEP--EK 980

Query: 313  DMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDH----------------FTKAQR 356
               + +EK  +    +  + EQ++       +++ W+                   + ++
Sbjct: 981  RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040

Query: 357  KNISVWCKQAEEIRNIHNDE--LMG--------------IRREEEMEMSDDEI--EEMTE 398
            + +    +Q  E   +  +E  L+G               R+EEE++  ++++  EE  +
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100

Query: 399  TKETEESALVSQAEALKEENDSL---------RWQLD-AYRNEVELLKQEQGKVHREDDP 448
             +  E      + E L++E + L         R +L+  YR E E+ ++E+  +  E + 
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160

Query: 449  NKEQQLKLL---QQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
             + Q+L+     ++ LQ  ++ LL+ ++E +++E E +  ++++LQ +K  +  ++++
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 71/309 (22%), Positives = 125/309 (40%), Gaps = 20/309 (6%)

Query: 199 RLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEK 258
           RL     Q RD+   W  +Q    REER   R EEE+L+         + D E     E 
Sbjct: 160 RLEQRDRQRRDEEL-WRQRQEWQEREER---RAEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 259 LKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAK 318
           L+   K  E  Q      +           +            +L  E+   +++++E +
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 319 EKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHND-EL 377
           E+ ++     L +  Q         +Q+      + +RK      +Q EE R      E 
Sbjct: 276 EQLRKLERQELRRERQ-----EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ 330

Query: 378 MGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQ 437
              RRE+++    +E  E    +E EE     Q    +E+ +  R Q    R E +L ++
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLR--REQEEERREQ--QLRREQQLRRE 386

Query: 438 EQGKVHREDDPNKEQQLKLLQQALQGMQ----QHLLKVQEEYKKKEAELEKLKDDKLQVE 493
           +Q  + RE    +EQQL+  QQ  +  Q    Q L + Q+  +++E E  + K ++ + E
Sbjct: 387 QQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444

Query: 494 KMLENLKEK 502
           + L+  +E+
Sbjct: 445 QRLKREQEE 453



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 22/217 (10%)

Query: 333 EQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI-RNIHNDELMGIRREEEMEMSDD 391
           EQ    +    +Q+  +   K +++    W K+ EE  R+        ++R++E E  + 
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487

Query: 392 ----EIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDD 447
               E EE  E +E  E  L  + E  +E+   L+ Q +  R +  L  ++Q  + RE +
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQR--LKRQEEEERLQQRLRSEQQ--LRREQE 543

Query: 448 PNKEQQLKLLQQ---ALQGMQQHLLKVQEEYK----KKEAELEKLKDDKLQVEKMLENLK 500
             +EQ LK  ++     +  +Q L + QEE +    K+E E  + +  + Q E++ + LK
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603

Query: 501 EKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALL 537
            +E    RL    +  E   ++     P +  R+ LL
Sbjct: 604 REE--VERL----EQEERREQRLKREEPEEERRQQLL 634



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 52/210 (24%), Positives = 99/210 (47%), Gaps = 21/210 (10%)

Query: 310 HEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369
           HE++  E + K +Q      ++ E+    +    +++      + +R+    W K  EE 
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER--WLKLEEEE 495

Query: 370 RNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYR 429
           R    +     RRE+++    +E  E    ++ EE  L    + L+ E    R Q +  R
Sbjct: 496 RREQQE-----RREQQLRREQEERREQRLKRQEEEERL---QQRLRSEQQLRREQEE--R 545

Query: 430 NEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKK--EAELEKLKD 487
            E +LLK+E+ K  R +   +EQ+LK  Q+     +  LLK +EE +++  + E E+  +
Sbjct: 546 RE-QLLKREEEK--RLEQERREQRLKREQEE---RRDQLLKREEERRQQRLKREQEERLE 599

Query: 488 DKLQVEKMLENLKEKESCASRLCASNQDSE 517
            +L+ E+ +E L+++E    RL     + E
Sbjct: 600 QRLKREE-VERLEQEERREQRLKREEPEEE 628



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 45/330 (13%)

Query: 206  QARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKF 265
            Q RD  ++W+ +++     ER R+R+     RPP           E  + AE+ +     
Sbjct: 763  QRRDFTWQWQAEEK----SERGRQRLSA---RPPLR------EQRERQLRAEERQ----- 804

Query: 266  SEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQAL 325
             +  Q  L   E  E  RR        +Q      +    E+A   ++ E+         
Sbjct: 805  -QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED--------- 854

Query: 326  SGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE 385
             G+    E+  +      ++  W    + +R+  +++ K A + +     +L+   +EEE
Sbjct: 855  -GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL---QEEE 910

Query: 386  MEMSDDEIEEMTETKET-----EESALVSQAEALKEENDSLRWQLDA--YRNEVELLKQE 438
             E+  +E E+    ++      EE     + + L+EE +  R Q     YR + +L ++E
Sbjct: 911  EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970

Query: 439  QGKVHREDDPNKEQQLKLL---QQALQGMQQHLLKVQEEYKKK-EAELEKLKDDKLQ--V 492
            +  +  E +  + Q+ +     ++ LQ  ++ LL+ + E +++ E E +  K D+LQ   
Sbjct: 971  EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030

Query: 493  EKMLENLKEKESCASRLCASNQDSEYPLEK 522
            E++L   +EK     R     ++ E   E+
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEE 1060



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 64/365 (17%), Positives = 148/365 (40%), Gaps = 26/365 (7%)

Query: 186 IRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVV 245
           +R     +K+   R   D     ++  EW  ++ +L +EE   +  E +R R      + 
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR-----ELQ 272

Query: 246 HYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVN 305
              +    +  ++L+ + +  E  Q  L      ++ R+         +       R   
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLR--REQQLRRKQEEERREQQEERREQQERREQ 330

Query: 306 EKAAHEKDM-EEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCK 364
           ++   E+ +  E +E+ +Q L     +  +   +     +++      + Q+       +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 365 QAEEIR---NIHNDELM----GIRREE----EMEMSDDEIEEMTETKETEESALVSQAEA 413
           + +++R    +  ++ +     +RRE+    E ++  ++ EE  E K  +E         
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 414 LKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQ----QHLL 469
            +E  D L+ + +  R+E E  KQ+  +   E+   +E+ LKL ++  +  Q    Q L 
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEE--RRERWLKLEEEERREQQERREQQLR 508

Query: 470 KVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPI 529
           + QEE +++  + ++ ++++LQ     E    +E    R     ++ E  LE+      +
Sbjct: 509 REQEERREQRLKRQE-EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567

Query: 530 KSERE 534
           K E+E
Sbjct: 568 KREQE 572



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 50/294 (17%), Positives = 124/294 (42%), Gaps = 45/294 (15%)

Query: 213  EWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTL 272
            E + ++  L REER +RR +E                     +  + +++ +  +  + L
Sbjct: 1115 ELQQEEEQLLREEREKRRRQE---------------------LERQYREEEEVQQEEEQL 1153

Query: 273  LTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQF 332
            L   E  E  RR         Q      R     +   E+ + E +EK +Q       + 
Sbjct: 1154 LR--EEPEKRRR---------QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202

Query: 333  EQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEM--EMSD 390
            E++        +QK    +    +++   W  + E+   + ++++    RE E   ++ D
Sbjct: 1203 EEL-------QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255

Query: 391  DEIEEMTETKETEESALVSQAEALKEENDSLRW-QLDAYRNEVELLKQEQGKVHREDDPN 449
             ++ +    ++ +   L+ + +    E +  RW Q D +  E E L++E+ K  +  D  
Sbjct: 1256 SQLRDRQSQQDLQH--LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 450  KEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
             +++ +LL++  +  ++   +   +++++E  L++ ++  L+ ++     +E+E
Sbjct: 1314 SQEEKQLLREEREEKRRR-QETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 54/288 (18%), Positives = 120/288 (41%), Gaps = 30/288 (10%)

Query: 215  ECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLT 274
            E +++ L R+ER R+ +EEE        P +   + E  +  ++   D KF E  Q L  
Sbjct: 1630 EREEQQLHRQERDRKFLEEE--------PQLRRQEREQQLRHDR---DRKFREEEQLL-- 1676

Query: 275  WIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQ 334
              + GE  +          +     +RR   E+    K ++E ++  +Q L     + EQ
Sbjct: 1677 --QEGEEQQLRRQERDRKFREEEQQLRRQERER----KFLQEEQQLRRQELERKFREEEQ 1730

Query: 335  I--VAVYHSASKQKAWDHFTKAQR---KNISVWCKQAEEIRNIHNDELMGIRREEEMEMS 389
            +          +Q+ +    + ++   +      ++ E  R    +E +   REE+   S
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790

Query: 390  DDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPN 449
             +   +  E ++  +     Q    ++ +   RW+      +++L +QEQ ++ +E D  
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRP-QQRDGKYRWE----EEQLQLEEQEQ-RLRQERDRQ 1844

Query: 450  KEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLE 497
               + +   Q     ++  L  +EE K+++    KL+++ ++ ++  E
Sbjct: 1845 YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 60/308 (19%), Positives = 128/308 (41%), Gaps = 27/308 (8%)

Query: 215 ECKQRMLAREERHRR----RMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQ 270
           E +Q+ L RE++ RR    + EEE  R        H  +     +AE+ ++ ++  E ++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR--ERIK 698

Query: 271 TLLT---WIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDME---------EAK 318
           + +    W    E + R +   YS  +      RR   E+    ++ E           +
Sbjct: 699 SRIPKWQWQLESEADARQSK-VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757

Query: 319 EKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELM 378
           ++ ++       Q++          +  A     + + + +    +Q  E R +  +E  
Sbjct: 758 QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817

Query: 379 GIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQE 438
             RR +  E      +E+   +E E+     +A+ L+EE D L+   +  R++ +   Q+
Sbjct: 818 EQRRRQRRERE----KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 439 QGKVHREDDPNKEQQL---KLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKM 495
                 E+   +   L     LQ+ L+  QQ L + +EE +++E E  + ++ + Q  + 
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE 933

Query: 496 LENLKEKE 503
            E L+++E
Sbjct: 934 -EQLQQEE 940



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 57/318 (17%), Positives = 129/318 (40%), Gaps = 42/318 (13%)

Query: 223  REERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLK-------------------DDS 263
            R+ERHR+  EEE+L        +H  + +   + E+ +                    + 
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515

Query: 264  KFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDM---EEAKEK 320
            KF E  Q L     R +  R+       + +      RR   ++   E++    E  +++
Sbjct: 1516 KFLEEEQQL----HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571

Query: 321  FKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGI 380
              +       + E+   V     ++K  +   + +R+      +Q  + +   +++L+  
Sbjct: 1572 LSRQERDRKFRLEE-QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE 1630

Query: 381  RREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQG 440
            R E+++   + + + + E  +        Q    ++       QL     E +L +QE+ 
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690

Query: 441  KVHREDDP---NKEQQLKLLQQALQGMQQHLLKV--QEEYKKKEAELEKLK--------- 486
            +  RE++     +E++ K LQ+  Q  +Q L +   +EE  ++E E E+L+         
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750

Query: 487  -DDKLQVEKMLENLKEKE 503
             +++L+ E+  + L+ +E
Sbjct: 1751 EEEQLRPEREEQQLRRQE 1768



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 71/339 (20%), Positives = 139/339 (41%), Gaps = 46/339 (13%)

Query: 213  EWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTL 272
            E + ++  L REE+ +RR E ER           Y + E  +  +K K   +  E  ++ 
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERER----------QYREEE-ELQRQKRKQRYR-DEDQRSD 1222

Query: 273  LTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQF 332
            L W  + E  + +A      ++    + +   NE+    +D +    + +Q L  +L + 
Sbjct: 1223 LKW--QWEPEKENA------VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274

Query: 333  EQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDE 392
            ++          Q+   HF + ++       K+A+       +E   +R E E +    E
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQ-KEAKRRDRKSQEEKQLLREEREEKRRRQE 1333

Query: 393  IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDP---- 448
                T+ K  EE  L+ +    +EE    R + D    E EL  QEQG+   E++     
Sbjct: 1334 ----TDRKFREEEQLLQE----REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385

Query: 449  --------NKEQQLKLLQQALQGMQQHLLKVQEEYKK--KEAELEKLKDDKLQV---EKM 495
                     +EQQL+  ++  Q  Q    K +EE ++  ++    K ++++ QV   E+ 
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445

Query: 496  LENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSERE 534
             + L+E++          ++ E  L++       + ER+
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 41/178 (23%), Positives = 80/178 (44%), Gaps = 16/178 (8%)

Query: 353  KAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAE 412
            K +R+     C++ EE++      L   R +   +  + +  E  E ++ EE  L  + E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159

Query: 413  A---------LKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQG 463
                       +EE +  + +    R E E  +QE+ + +RE++  + Q+ K  Q+    
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK--QRYRDE 1217

Query: 464  MQQHLLKVQEEYKKKEAELEKLKDDKLQVE-KMLENLKEKESCASRLCASNQDSEYPL 520
             Q+  LK Q E +K+ A    ++D+K+  + +  E  ++ E    R   S QD ++ L
Sbjct: 1218 DQRSDLKWQWEPEKENA----VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 62/311 (19%), Positives = 119/311 (38%), Gaps = 54/311 (17%)

Query: 206 QARDDLYEWECKQRMLAREERHRR---RMEEERLRPPSPPPVVHYSDHECSIVAEKLKDD 262
           +  +  +E E +++ L RE+  RR   + EEE  R            HE     E+ K  
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETER------------HE----QERRKQQ 475

Query: 263 SKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFK 322
            K  +  +    W++  E  RR         +     +RR   E+       +E +E+ +
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQ------ERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 323 QALSGI-------------LIQFEQIVAVYHSASKQKAW-------DHFTKAQRKNISVW 362
           Q L                L++ E+   +     +Q+         D   K + +     
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589

Query: 363 CKQAEEIR---NIHNDELMGI----RREEEMEMSDDEIEEMTETKETEESALVSQAEALK 415
            K+ +E R    +  +E+  +    RRE+ ++  + E E   +  ++EE     Q + L+
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ-LR 648

Query: 416 EENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEY 475
            E    R Q      E E L+Q   + H E+   +E   +  +QA + ++  + K Q + 
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708

Query: 476 KKKEAELEKLK 486
            + EA+  + K
Sbjct: 709 -ESEADARQSK 718



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 18/184 (9%)

Query: 215  ECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLT 274
            E +Q  L R+ER+R+ +EEE+LRP      +   +            D KF E  Q    
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER-----------DRKFREEEQLRQ- 1781

Query: 275  WIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQ 334
              ER E   RS  +     +       R   +    ++D +   E+ +  L     +  Q
Sbjct: 1782 --EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839

Query: 335  IVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELM--GIRREEEMEMSDDE 392
                 + A +Q A     K++R+   +W ++ ++ R     +L    IRR+++ E    +
Sbjct: 1840 ERDRQYRAEEQFATQE--KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897

Query: 393  IEEM 396
            + E+
Sbjct: 1898 VGEI 1901


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 81/404 (20%), Positives = 165/404 (40%), Gaps = 28/404 (6%)

Query: 137  ENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKD 196
            EN ++ +I E+     +II   +  K   +I   +E  +++   L  +        DK D
Sbjct: 702  ENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKAD 761

Query: 197  TGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVA 256
            T  L ++     ++  E     +     ER  +R+ E  L+   PP     S H  S + 
Sbjct: 762  TSSLIINNKLICNETVEVPKDSKSKICSER--KRVNENELQQDEPP-AKKGSIHVSSAIT 818

Query: 257  EKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEE 316
            E    D K SE V+  +  IE   V + +     + + +  + ++    EKA   K +  
Sbjct: 819  E----DQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH 874

Query: 317  AKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQ-RKNISVWCKQAEEIRNIHND 375
             +++   +    L   +++  +  +     A  H  K++ ++      K + EI      
Sbjct: 875  FQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRS 934

Query: 376  ELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALK--EENDSLRWQLDAYRNEVE 433
                + + + M    DE+  +    +     L++  +     EE++    QLD   N+  
Sbjct: 935  ITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDY- 993

Query: 434  LLKQEQGKVHREDDPNKE-----------QQLKLLQQALQGMQQHLLKVQEEYKKKEAEL 482
             L  +Q K +R  +PN+E           ++ K + +A       + +++++ +K +AE+
Sbjct: 994  -LVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEV 1052

Query: 483  EKLKDDKLQV-EKMLEN----LKEKESCASRLCASNQDSEYPLE 521
            +  KD+  ++ EK  +N    LKEKE+   +L    Q+    L+
Sbjct: 1053 KGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLD 1096



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 55/285 (19%), Positives = 128/285 (44%), Gaps = 18/285 (6%)

Query: 229  RRMEEERLRPPSPPPVVHYSDH----ECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRR 284
            ++++E R++ P+     H S      EC    E +K  SK S  ++ L   IE+ +   +
Sbjct: 997  KQVKEYRIQEPNRENSFHSSIEAIWEECK---EIVKASSKKSHQIEELEQQIEKLQAEVK 1053

Query: 285  SANNFYSMI-QSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSAS 343
               +  + + +  + +   L+ EK   E  +++ KE+ ++    + +Q + +V    + S
Sbjct: 1054 GYKDENNRLKEKEHKNQDDLLKEK---ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALS 1110

Query: 344  KQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEE-----MEMSDDEIEEMTE 398
            +        KA+ K +     + +++   H+ +L     E+E     +E +  E +E  +
Sbjct: 1111 ELTQGVTCYKAKIKELET-ILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQ 1169

Query: 399  TKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQ 458
                    L  +   LKEE   L   L   ++ ++L K+E+ + +R++    +++L    
Sbjct: 1170 DSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQL-KEEEEETNRQETEKLKEELSASS 1228

Query: 459  QALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
               Q ++  L + +E+Y   + +L   K    QV+K +  +++++
Sbjct: 1229 ARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDED 1273



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 35/175 (20%), Positives = 79/175 (45%), Gaps = 14/175 (8%)

Query: 367  EEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLD 426
            +E  + + D+L+   +E  ++   +E++E   T + +   +V    AL E    L   + 
Sbjct: 1063 KEKEHKNQDDLLK-EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSE----LTQGVT 1117

Query: 427  AYRNEVELLKQ--EQGKVH-------REDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKK 477
             Y+ +++ L+   E  KV         +D   KE  +  L++ L+  Q+HL    +  K 
Sbjct: 1118 CYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKD 1177

Query: 478  KEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSE 532
               +  KLK++  Q+   L+++K           +N+     L++ +++S  +++
Sbjct: 1178 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQ 1232


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 83/413 (20%), Positives = 167/413 (40%), Gaps = 72/413 (17%)

Query: 137  ENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKD 196
            E    ++ +E+ +    +  + K+K NF  +    E  + +       + RL +    + 
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQK 1281

Query: 197  TGRLHVDFAQARDDLYEWEC--------KQRMLAREERHRRRMEEERLRPPSPPPVVHYS 248
              RLH +  +    L E +         KQ    + E  +R++EEE     +    +  +
Sbjct: 1282 A-RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSA 1340

Query: 249  DHECSIVAEKLKDDSK--------FSEAVQTLLTW--------IERGEVNRRSANNFYSM 292
             H+C ++ E+ +++ +         S+A   +  W        I+R E    +       
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400

Query: 293  IQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQI-VAVYHSASKQKAWDHF 351
            +Q A  HV   VN K A    +E+ K++ +  +  ++I  E+   A      KQ+ +D  
Sbjct: 1401 LQDAEEHV-EAVNSKCA---SLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD-- 1454

Query: 352  TKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIE----EMTETKETEESAL 407
                 K ++ W ++ EE              + E+E S  E      E+ + K   E +L
Sbjct: 1455 -----KVLAEWKQKYEE-------------TQAELEASQKESRSLSTELFKVKNAYEESL 1496

Query: 408  VSQAEALKEENDSLRWQLDAYRNEVE---LLKQEQGKVHREDDPNKEQQLKLLQQA---L 461
                E LK EN +L+ ++     ++        E  KV ++ D  K +    L++A   L
Sbjct: 1497 -DHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555

Query: 462  QGMQQHLLKVQEEYK-----------KKEAELEKLKDDKLQVEKMLENLKEKE 503
            +  +  +L++Q E             +K+ EL++LK + L+V + +++  + E
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAE 1608



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 50/262 (19%), Positives = 115/262 (43%), Gaps = 25/262 (9%)

Query: 257  EKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEE 316
            E  K ++K  E  + ++T ++     +         +  A     +L+  K   E  ++E
Sbjct: 866  ELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKE 925

Query: 317  AKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDE 376
              E+ +          E+ +    +A K+K  D  ++ ++    +    A+  +  H  E
Sbjct: 926  VTERAED---------EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976

Query: 377  LMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSL------RWQLDAYRN 430
                   EEM   D+ I ++T+ K+  + A     + L+ E D +      + +L+   +
Sbjct: 977  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036

Query: 431  EVELLKQEQGKVHREDDPNK---EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELE---- 483
            ++E   +++ K+  + +  K   E  LKL Q++    +    ++ E+ KKKE E+     
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQG 1096

Query: 484  KLKDDK---LQVEKMLENLKEK 502
            K++D++   +Q++K ++ L+ +
Sbjct: 1097 KIEDEQALAIQLQKKIKELQAR 1118



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 31/129 (24%), Positives = 57/129 (44%), Gaps = 5/129 (3%)

Query: 381  RREEEMEMSD--DEIEEMTETKETEESALVSQAEALKE---ENDSLRWQLDAYRNEVELL 435
            R + E + SD   E+EE++E  E    A  +Q E  K+   E   +R  L+    + E  
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEAT 1192

Query: 436  KQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKM 495
                 K H +      +Q+  LQ+  Q +++   +++ E     + +E +   K   EKM
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252

Query: 496  LENLKEKES 504
               L+++ S
Sbjct: 1253 CRTLEDQLS 1261



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 29/142 (20%), Positives = 66/142 (46%), Gaps = 22/142 (15%)

Query: 366  AEEIRNIH--NDELMGIRREEEMEMS------DDEIEEMTETKETEESALVS---QAEAL 414
            +E ++ +H  N  L+  +++ E ++S      +D ++E    +E  + A+      AE L
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEEL 1773

Query: 415  KEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEE 474
            K+E D+        +N  + +K  Q ++   +           Q AL+G ++ + K++  
Sbjct: 1774 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE-----------QLALKGGKKQIQKLEAR 1822

Query: 475  YKKKEAELEKLKDDKLQVEKML 496
             ++ E+E+E  +   ++  K L
Sbjct: 1823 VRELESEVESEQKHNVEAVKGL 1844


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 69/322 (21%), Positives = 132/322 (40%), Gaps = 44/322 (13%)

Query: 213  EWECKQRMLAREERHRR------RMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFS 266
            E E K++ +  E+RH +      R+  +R R                   ++ +++ K +
Sbjct: 1553 EGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEK----------------KRAQEERKLA 1596

Query: 267  EAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALS 326
            +  + L     +     R     Y  I   +  + +   + A  E+ + +  EK  Q   
Sbjct: 1597 QEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAE 1656

Query: 327  GILIQFEQIVAVYHSASKQK---AWDHFTKAQRKNISVWCKQAEEI----RNIHNDELMG 379
             +  + +++   +   ++++   A      A+ KNI    ++ EE+    +N+   E   
Sbjct: 1657 KLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA--QKVEELPQREQNLDWQEKEL 1714

Query: 380  IRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLD-------AYRNEV 432
             +  EE+E   +E+    E    EE  LV + + L EE ++L WQ +           E 
Sbjct: 1715 AQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEE 1774

Query: 433  ELLKQEQGKV--HREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKL 490
            ELL QE+ K+  H+E  P +E++L   ++ L   +  L + +E +     EL K K    
Sbjct: 1775 ELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILY 1834

Query: 491  QVEKMLENLK----EKESCASR 508
            Q + + +  K    EKE  A R
Sbjct: 1835 QKKNLAQEKKNLAQEKEKLAQR 1856



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 68/329 (20%), Positives = 145/329 (44%), Gaps = 32/329 (9%)

Query: 219  RMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLK-DDSKFSEAVQTLLTWIE 277
            + L +  R  R++ +E ++       +   +   SI   KL   +  FSE         +
Sbjct: 2078 KALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE---------K 2128

Query: 278  RGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVA 337
            R E+ +          + AN  +RR++N+    E+ M E + K  +  S +++  E+   
Sbjct: 2129 RSELTKDEKKLARKQRKLANK-MRRMINK----EEKMTEEESKLARKHSEVILDDEEEGG 2183

Query: 338  VYHSAS---KQKAWDHFTKAQR--KNISVWCKQAEEIRNIHN--DELMGIRREEEME--M 388
            +         ++ W    +A+R  K    +  Q +E+ +  +  +E+  +  E E +  +
Sbjct: 2184 IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243

Query: 389  SDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGK--VHRED 446
            S +E EE  E +E EE  +  + E  KEE +    Q++    E +  K+E+ K  V  ++
Sbjct: 2244 SSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKE 2303

Query: 447  DPNKEQQLKLLQQALQGM-----QQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE 501
            +  +E++  + ++  + +     ++    ++EE  +++  L+K K  KLQ E+  ++L+ 
Sbjct: 2304 EVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQ-EQRRKSLRG 2362

Query: 502  KESCASRLCASNQDSEYPLEKTMNSSPIK 530
            +E   S L          +   +  SP+K
Sbjct: 2363 RERVLSILRGVPHGKGRAIRLGVLKSPLK 2391



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 57/250 (22%), Positives = 109/250 (43%), Gaps = 28/250 (11%)

Query: 300  VRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQ---KAWDHFTKAQ- 355
            V ++  E    E+DM E  E+       ++ Q  ++V +  + S Q   KAWD + +   
Sbjct: 1413 VGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHG 1472

Query: 356  --RKNISVWCKQAEEIRNIHNDELMG-----IRREEEMEMSDDEI---------EEMTET 399
              RK+   W K+  E R +  +E +      +  EEEM   D ++         E M  +
Sbjct: 1473 ETRKSWKAW-KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSS 1531

Query: 400  KETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGK---VHRE----DDPNKEQ 452
            K  E+     +   L+EE      + +    E +   QE+ K   +HR+    +    ++
Sbjct: 1532 KSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQE 1591

Query: 453  QLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCAS 512
            + KL Q+  +  Q+     QEE K  +A ++  +DD+   +   +  +++E+ A R    
Sbjct: 1592 ERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKL 1651

Query: 513  NQDSEYPLEK 522
            +Q++E   +K
Sbjct: 1652 SQEAEKLAQK 1661



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 60/319 (18%), Positives = 127/319 (39%), Gaps = 25/319 (7%)

Query: 213  EWECKQRMLAREER-----HRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSE 267
            EWE  +R+L  EE+      +   EEE L+         +     ++++ K K+     E
Sbjct: 1484 EWE--KRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541

Query: 268  AVQTLLTWIER-GEVNRRSANNFYSMIQSANSHVR------RLVNEKAAHEKDMEEAKEK 320
               TL   + R GE   +        IQ  +   R      R   ++A  E+ + + +EK
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601

Query: 321  FKQALSGILIQFEQIVAVYHSASKQ-----KAWDHFTKAQRKNISVWCKQAEEIRNIHND 375
              Q    +  +  ++   Y   ++      +A   F + +        K ++E   +   
Sbjct: 1602 LAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQK 1661

Query: 376  ELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELL 435
                 ++ E++   ++++ +        ++ L  + E L +   +L WQ      E+E L
Sbjct: 1662 RKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEEL 1721

Query: 436  KQEQGKVH-REDDPNKE-----QQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDK 489
            + +  ++  +E++ N+E     ++ K L +  + +     K+ EE  K   E E L  +K
Sbjct: 1722 EWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEK 1781

Query: 490  LQVEKMLENLKEKESCASR 508
             ++ +  E + E+E    R
Sbjct: 1782 EKLAQHKEKMPEEEERLGR 1800



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/197 (21%), Positives = 90/197 (45%), Gaps = 13/197 (6%)

Query: 344  KQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETE 403
            ++K  +  +K  RK+  V     EE   I  +E++   +    +  + +  +  + K + 
Sbjct: 2157 EEKMTEEESKLARKHSEVILDDEEE-GGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215

Query: 404  ESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQAL-- 461
            +   V   E   EE +SL  +L+    + E L  E+ +   E++  +E++++  ++    
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELE----KQESLSSEEEEEREEEEEREEEEVREEEEERKE 2271

Query: 462  --QGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYP 519
              +G ++ + K +EE KKK+   EK K++  + E++ E  +++E  +     S  D E  
Sbjct: 2272 EEEGEEKQVEKEEEEKKKKKK--EKKKEEVQEKEEVFE--EKEEIMSEEETESLSDEEEE 2327

Query: 520  LEKTMNSSPIKSEREAL 536
             E       +  E+E L
Sbjct: 2328 EESCSLEEEVDREKEIL 2344



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 51/230 (22%), Positives = 103/230 (44%), Gaps = 26/230 (11%)

Query: 294  QSANSHVRRLVNEKAAHEKDMEEA--KEKFKQALSGILIQFEQIVAVYHSA---SKQKAW 348
            Q+ +   + L  E    E DMEE   KE+      G L++ ++ +A    A    ++K  
Sbjct: 1705 QNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLS 1764

Query: 349  DHFTK-AQRKNISVWCKQA---EEIRNIHNDELMGIRREEEMEMSD----------DEIE 394
            +  TK AQ + + +  K+     + +    +E +G +RE+ +E             + +E
Sbjct: 1765 EEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME 1824

Query: 395  EMTETKET--EESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQ 452
            E+T+ K    ++  L  + + L +E + L     A R E  L  +E+    ++     + 
Sbjct: 1825 ELTKNKMILYQKKNLAQEKKNLAQEKEKL-----AQRKENLLYNKERLTHSKKQLVQVKN 1879

Query: 453  QLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEK 502
            +L +  + L  +++ L + +E   KK+ +L + +   +QVE  L   +EK
Sbjct: 1880 KLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEK 1929



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 40/219 (18%), Positives = 102/219 (46%), Gaps = 23/219 (10%)

Query: 303  LVNEK---AAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNI 359
            L+ EK   A H++ M E +E+  +    ++ +  ++      A K++ W +  +   KN 
Sbjct: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL------AQKRERWINSMEELTKNK 1830

Query: 360  SVWCKQ---AEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKE 416
             +  ++   A+E +N+  ++    +R+E +  + + +    +     ++ L    + L +
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQ 1890

Query: 417  ENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQAL---------QGMQ-- 465
              + L  + +    + E L + + K+ + +D   ++Q KL Q+ +         QG +  
Sbjct: 1891 VEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRL 1950

Query: 466  QHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKES 504
            +  L + +E K    E+++L ++K+++ +  E L + E+
Sbjct: 1951 RGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGET 1989


>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
           sapiens]
          Length = 479

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 52/216 (24%), Positives = 98/216 (45%), Gaps = 14/216 (6%)

Query: 291 SMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSA--SKQKAW 348
           ++I     ++  LV      +K      +K  ++L  +  Q  + +A    A  SK +  
Sbjct: 103 AIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQL 162

Query: 349 DHFTKAQRKNISVWCKQAE-EIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESAL 407
              T   RK +    +Q + E+ N     L+  R+EE +   ++ + E  E    +E  L
Sbjct: 163 QDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLHEQEERLHEQEERL 222

Query: 408 VSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQH 467
             Q E L E+ + LR Q        E L++++ ++H +++   EQ+ +L +Q  +  +Q 
Sbjct: 223 CEQEERLCEQEERLREQ-------EERLREQEERLHEQEERLCEQEERLCEQEERLCEQE 275

Query: 468 LLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKE 503
            L  QE   +   E+EKL + + + E+  E L E+E
Sbjct: 276 KLPGQERLLE---EVEKLLEQERRQEEQ-ERLLERE 307



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 36/150 (24%), Positives = 73/150 (48%), Gaps = 8/150 (5%)

Query: 391 DEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNK 450
           +++++ T     E  ++  Q +A  E N  L   L   R E  L +QE+ ++H +++   
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQML--SLLNRRQEERLREQEE-RLHEQEERLH 216

Query: 451 EQQLKLLQQALQ-GMQQHLLKVQEEYKKKEAELEKLKDDKL--QVEKMLENLKEKESCAS 507
           EQ+ +L +Q  +   Q+  L+ QEE  +++ E    ++++L  Q E++ E  +E+  C  
Sbjct: 217 EQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEERLCE--QEERLCEQ 274

Query: 508 RLCASNQDSEYPLEKTMNSSPIKSEREALL 537
                 +     +EK +     + E+E LL
Sbjct: 275 EKLPGQERLLEEVEKLLEQERRQEEQERLL 304


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,417,994
Number of Sequences: 37866
Number of extensions: 1346121
Number of successful extensions: 16450
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 1044
Number of HSP's that attempted gapping in prelim test: 9410
Number of HSP's gapped (non-prelim): 5179
length of query: 610
length of database: 18,247,518
effective HSP length: 108
effective length of query: 502
effective length of database: 14,157,990
effective search space: 7107310980
effective search space used: 7107310980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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