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Search of human proteins with 32455250
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1
(alpha) isoform 3 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 866 0.0
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 853 0.0
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 853 0.0
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 682 0.0
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 682 0.0
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 659 0.0
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 59 8e-09
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 59 8e-09
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 58 1e-08
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 56 5e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 56 7e-08
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 55 9e-08
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 55 1e-07
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 55 1e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 54 3e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 54 3e-07
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 54 3e-07
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 54 3e-07
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 54 3e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 54 4e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 54 4e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 54 4e-07
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 54 4e-07
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 54 4e-07
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 52 8e-07
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 52 8e-07
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 52 8e-07
gi|148596974 TXK tyrosine kinase [Homo sapiens] 52 8e-07
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 52 8e-07
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 52 8e-07
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 866 bits (2238), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA 60
MHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
Sbjct: 1 MHNLQTLPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA 60
Query: 61 STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL 120
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
Sbjct: 61 STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL 120
Query: 121 DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK 180
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
Sbjct: 121 DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK 180
Query: 181 RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID 240
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
Sbjct: 181 RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID 240
Query: 241 SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN 300
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
Sbjct: 241 SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN 300
Query: 301 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 360
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
Sbjct: 301 ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS 360
Query: 361 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 420
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
Sbjct: 361 VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 420
Query: 421 QQRR 424
QQRR
Sbjct: 421 QQRR 424
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 853 bits (2205), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 7 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 66
LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG
Sbjct: 37 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 96
Query: 67 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 126
DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY
Sbjct: 97 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 156
Query: 127 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 186
PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA
Sbjct: 157 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 216
Query: 187 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 246
FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE
Sbjct: 217 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 276
Query: 247 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 306
EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ
Sbjct: 277 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 336
Query: 307 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 366
YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE
Sbjct: 337 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 396
Query: 367 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 424
VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Sbjct: 397 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 454
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 853 bits (2205), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 7 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 66
LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG
Sbjct: 307 LPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHG 366
Query: 67 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 126
DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY
Sbjct: 367 DYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLY 426
Query: 127 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 186
PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA
Sbjct: 427 PVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEA 486
Query: 187 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 246
FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE
Sbjct: 487 FNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLE 546
Query: 247 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 306
EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ
Sbjct: 547 EDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQ 606
Query: 307 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 366
YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE
Sbjct: 607 YSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGE 666
Query: 367 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 424
VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
Sbjct: 667 VKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 724
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 682 bits (1761), Expect = 0.0
Identities = 336/419 (80%), Positives = 377/419 (89%), Gaps = 4/419 (0%)
Query: 7 LPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM 64
LPPKPPKP T A NGM ++++SLQDAEWYWGDISREEVN+KLRD DGTFLVRDASTKM
Sbjct: 37 LPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKM 96
Query: 65 HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL 124
GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDVKL
Sbjct: 97 QGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKL 156
Query: 125 LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI 184
+YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRTAI
Sbjct: 157 MYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAI 216
Query: 185 EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR 244
EAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+ R
Sbjct: 217 EAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMR 276
Query: 245 LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NEN 302
LE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL KGVRQK+LN WLG NE+
Sbjct: 277 LEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNED 336
Query: 303 TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVV 362
++ Y + E+DE+LPH+DEKTW V NR +AE+LL GK DG FL+RESSK+GCYACSVV
Sbjct: 337 ADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVV 396
Query: 363 VDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ 421
DGEVKHCVI TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+AQ
Sbjct: 397 ADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
Score = 66.6 bits (161), Expect = 4e-11
Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 381
W G +R + + LR DGTFLVR++S QG Y ++ G K I YGF
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 382 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
++P ++S+ EL+ HY H SL Q+N L+V L YPV Q+
Sbjct: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 682 bits (1761), Expect = 0.0
Identities = 336/419 (80%), Positives = 377/419 (89%), Gaps = 4/419 (0%)
Query: 7 LPPKPPKPTTVA-NNGM-NNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKM 64
LPPKPPKP T A NGM ++++SLQDAEWYWGDISREEVN+KLRD DGTFLVRDASTKM
Sbjct: 37 LPPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKM 96
Query: 65 HGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKL 124
GDYTLTLRKGGNNKLIKI+HRDGKYGFSDPLTF+SVVELINHY +ESLAQYNPKLDVKL
Sbjct: 97 QGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKL 156
Query: 125 LYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAI 184
+YPVS+YQQDQ+VKEDNI+AVGKKL EY++Q+QEKS+EYDRLYEEYTRTSQEIQMKRTAI
Sbjct: 157 MYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAI 216
Query: 185 EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRR 244
EAFNETIKIFEEQC TQE++SKEYIE+F+REGNEKEI+RIM NYDKLKSR+ EI DS+ R
Sbjct: 217 EAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMR 276
Query: 245 LEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG--NEN 302
LE+DLK QA + REIDK+MNSIKPDLIQLRK RDQ+L+WL KGVRQK+LN WLG NE+
Sbjct: 277 LEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNED 336
Query: 303 TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVV 362
++ Y + E+DE+LPH+DEKTW V NR +AE+LL GK DG FL+RESSK+GCYACSVV
Sbjct: 337 ADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVV 396
Query: 363 VDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQ 421
DGEVKHCVI TA GYGFAEPYNLYSSLKELVLHYQ TSLVQHNDSLNV LAYPV+AQ
Sbjct: 397 ADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 455
Score = 66.6 bits (161), Expect = 4e-11
Identities = 40/102 (39%), Positives = 56/102 (54%), Gaps = 3/102 (2%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINKTATGYGF 381
W G +R + + LR DGTFLVR++S QG Y ++ G K I YGF
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGF 124
Query: 382 AEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
++P ++S+ EL+ HY H SL Q+N L+V L YPV Q+
Sbjct: 125 SDPLT-FNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQ 165
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 659 bits (1700), Expect = 0.0
Identities = 319/419 (76%), Positives = 374/419 (89%), Gaps = 7/419 (1%)
Query: 7 LPPKPPK----PTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 62
LPPKPPK PT +AN G + SLQDAEWYWGDISREEVNEKLRDT DGTFLVRDAS+
Sbjct: 302 LPPKPPKAKPAPTVLANGG--SPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASS 359
Query: 63 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 122
K+ G+YTLTLRKGGNNKLIK+FHRDG YGFS+PLTF SVV+LINHYR+ESLAQYN KLD
Sbjct: 360 KIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDT 419
Query: 123 KLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRT 182
+LLYPVSKYQQDQ+VKED++EAVG +L Y+ Q+Q+KSREYD+LYEEYTRTSQE+QMKRT
Sbjct: 420 RLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRT 479
Query: 183 AIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSR 242
AIEAFNETIKIFEEQ QTQE+ SKEY+E+F+REGNEKE+QRI+ N ++LKSRI+EI +SR
Sbjct: 480 AIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESR 539
Query: 243 RRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNEN 302
+LE+ L+ QA++ REIDKRMNS+KPDL+QLRK RDQYL+WLTQKG RQKK+NEWLG +N
Sbjct: 540 TKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKN 599
Query: 303 -TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSV 361
TEDQY+L+ED++DLPHH+E+TW VG NR +AE +L GKRDGTFL+RESS++GCYACSV
Sbjct: 600 ETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSV 659
Query: 362 VVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 420
VVDG+ KHCVI +TATG+GFAEPYNLY SLKELVLHYQH SLVQHND+L VTLA+PV A
Sbjct: 660 VVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRA 718
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 317 PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINK 374
P + W G +R + LR DGTFLVR++S QG Y ++ G K +
Sbjct: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
Query: 375 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
YGF+EP + S+ +L+ HY+H SL Q+N L+ L YPV Q+
Sbjct: 383 RDGHYGFSEPLT-FCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQ 430
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 58.9 bits (141), Expect = 8e-09
Identities = 31/95 (32%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
WY G + R + +L + + T+LVR TK G+Y ++++ K IKI RDG +
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHR-TKESGEYAISIKYNNEAKHIKILTRDGFFHI 170
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYP 127
++ F S++EL+ +Y++ SL + LD L +P
Sbjct: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
Score = 52.8 bits (125), Expect = 6e-07
Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSKQ-GCYACSVVVDGEVKHCVINKTATGYGFA 382
W G+ R +AE L + + T+LVR +K+ G YA S+ + E KH I T G+
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHI 170
Query: 383 EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ SL ELV +Y+H SL + +L+ TL +P
Sbjct: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 58.9 bits (141), Expect = 8e-09
Identities = 31/95 (32%), Positives = 53/95 (55%), Gaps = 1/95 (1%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
WY G + R + +L + + T+LVR TK G+Y ++++ K IKI RDG +
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHR-TKESGEYAISIKYNNEAKHIKILTRDGFFHI 730
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYP 127
++ F S++EL+ +Y++ SL + LD L +P
Sbjct: 731 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765
Score = 52.8 bits (125), Expect = 6e-07
Identities = 34/95 (35%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSKQ-GCYACSVVVDGEVKHCVINKTATGYGFA 382
W G+ R +AE L + + T+LVR +K+ G YA S+ + E KH I T G+
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKI-LTRDGFFHI 730
Query: 383 EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ SL ELV +Y+H SL + +L+ TL +P
Sbjct: 731 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 58.2 bits (139), Expect = 1e-08
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 90
WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+
Sbjct: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104
Query: 91 GFSDPL-------TFSSVVELINHY 108
+ F SVV LI++Y
Sbjct: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129
Score = 29.3 bits (64), Expect = 7.1
Identities = 13/29 (44%), Positives = 19/29 (65%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESS 352
W GS N+A+ L+ +GTFL+R+SS
Sbjct: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 56.2 bits (134), Expect = 5e-08
Identities = 41/112 (36%), Positives = 54/112 (48%), Gaps = 5/112 (4%)
Query: 314 EDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGC-YACSVVVDGEVKHCVI 372
+DL H W G R AE++L + DGTFLVR+ K +A S+ + EVKH I
Sbjct: 664 QDLSVH---LWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
Query: 373 NKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR 424
TA G + L ELV YQ SL SL+ TL +P ++R
Sbjct: 721 -MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKR 771
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
WY G + R L + +DGTFLVR K ++ ++++ K IKI +G Y
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQR-VKDAAEFAISIKYNVEVKHIKIMTAEGLYRI 729
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYP 127
++ F + EL+ Y+ SL LD L +P
Sbjct: 730 TEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 764
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 55.8 bits (133), Expect = 7e-08
Identities = 50/216 (23%), Positives = 100/216 (46%), Gaps = 24/216 (11%)
Query: 138 KEDNIEAVGKKLHEYNT--QFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFE 195
KE+ I + +K+HE + +EK +E +++ E+ R QE +M R E I+ E
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ-----EEKIREQE 443
Query: 196 EQCQTQER---YSKEYI---EKFKREGNEKEIQRIMHNYDKL---------KSRISEIID 240
E+ + QE+ +E I EK + E +E + + +K+ K ++ E +
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 241 SRRRLEEDLKKQAAEYREIDKRMNSIKPDL-IQLRKTRDQYLMWLTQKGVRQKKLNEWLG 299
R+ EE + +Q + RE ++++ + + Q K R+Q MW ++ + +++ W
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE-KIWEE 562
Query: 300 NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAE 335
+ E + + +E + +EK W R + E
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEE 598
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/170 (24%), Positives = 82/170 (48%), Gaps = 15/170 (8%)
Query: 157 QEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREG 216
+EK E ++++EE R QE +M R E I+ EE+ QE +E E KR+
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQ-----EEKIREQEEKVWRQEEKIREQEE--KRQE 602
Query: 217 NEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLI-QLRK 275
E+++ + + + +I E + R EE +++Q +E +++M + + Q K
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 662
Query: 276 TRDQ-YLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTW 324
++Q MW ++ +R+++ + E + + E +E + +EK W
Sbjct: 663 MQEQEETMWRQEEKIREQE------KKIREQEEKIREQEEMMQEQEEKMW 706
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/221 (22%), Positives = 98/221 (44%), Gaps = 24/221 (10%)
Query: 108 YRN----ESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQF--QEKSR 161
YRN E L + N KL KL S+ + Q+ N++ + +KL Q+
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVESEKSEIQL----NVKELKRKLERAKLLLPQQQLQA 265
Query: 162 EYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEI 221
E D L +E S ++Q + E +N + EE+ QE +E+ EK + + E++I
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ--EEKI 323
Query: 222 QRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYL 281
+ + + +I E + RR EE + ++ + R ++ M + + R + +
Sbjct: 324 R-------EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM-----RRQEEM 371
Query: 282 MWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEK 322
MW ++ +R+++ W E + + + E + +EK
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Score = 35.0 bits (79), Expect = 0.13
Identities = 26/140 (18%), Positives = 70/140 (50%), Gaps = 7/140 (5%)
Query: 131 YQQDQVVKE--DNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFN 188
++Q++ ++E + I+ +K+ E + +E+ E+ +++ + ++
Sbjct: 608 WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Query: 189 ETIKIFEEQCQTQERYSKEYIEKFK--REGNEKEIQRIMHNYDKL---KSRISEIIDSRR 243
ET+ EE+ + QE+ +E EK + E +++ +++ +K+ + ++ E + R
Sbjct: 668 ETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727
Query: 244 RLEEDLKKQAAEYREIDKRM 263
R EE + +Q R+ +++M
Sbjct: 728 RQEEKMWEQEVRLRQQEEKM 747
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 55.5 bits (132), Expect = 9e-08
Identities = 36/101 (35%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 319 HDEKTWNVGSSNRNKAENLL-RGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTAT 377
H+ K W S +R +AE++L R RDG FL+R+ YA + G+VKHC IN+
Sbjct: 641 HESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGR 700
Query: 378 GYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 418
+ + SL ELV +Y+ SL + + L YPV
Sbjct: 701 HFVLGTS-AYFESLVELVSYYEKHSLYR-----KMRLRYPV 735
Score = 48.1 bits (113), Expect = 1e-05
Identities = 41/108 (37%), Positives = 53/108 (49%), Gaps = 16/108 (14%)
Query: 311 EDDEDLP----HHDEKTWNVGSSNRNKAENLLR------GKRDGTFLVRESSK-QGCYAC 359
E +D+P H EK ++ R AE LL+ G +DGTFLVRES Y
Sbjct: 516 EVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTL 575
Query: 360 SVVVDGEVKHCVINKTATGYGFAEPY---NL-YSSLKELVLHYQHTSL 403
S G V+HC I T G G + Y NL +SS+ L+ HY+ T L
Sbjct: 576 SFWRSGRVQHCRIRSTMEG-GTLKYYLTDNLTFSSIYALIQHYRETHL 622
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/93 (35%), Positives = 46/93 (49%), Gaps = 12/93 (12%)
Query: 32 EWYWGDISREEVNEKLRDT-------ADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIF 84
+W+ + + EKL DGTFLVR++ T DYTL+ + G + +I
Sbjct: 531 KWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESET-FPNDYTLSFWRSGRVQHCRIR 589
Query: 85 HR-DG---KYGFSDPLTFSSVVELINHYRNESL 113
+G KY +D LTFSS+ LI HYR L
Sbjct: 590 STMEGGTLKYYLTDNLTFSSIYALIQHYRETHL 622
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 55.1 bits (131), Expect = 1e-07
Identities = 50/183 (27%), Positives = 85/183 (46%), Gaps = 22/183 (12%)
Query: 248 DLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQY 307
+LKK A Y + N + QLRK D+Y + L + + + + G E
Sbjct: 215 ELKKVVALYDYMPMNANDL-----QLRKG-DEYFI-LEESNLPWWRARDKNGQEGYIPSN 267
Query: 308 SLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGK-RDGTFLVRESSKQGCYACSVVV--- 363
+ E ++ + ++ W R++AE LL+ + ++G F+VR+SSK G Y SV
Sbjct: 268 YVTEAEDSIEMYE---WYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKST 324
Query: 364 ---DGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 420
G ++H V+ T + +L+S++ EL+ ++QH S L L YPV
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSA-----GLISRLKYPVSQ 379
Query: 421 QQR 423
Q +
Sbjct: 380 QNK 382
Score = 38.5 bits (88), Expect = 0.012
Identities = 30/116 (25%), Positives = 58/116 (50%), Gaps = 15/116 (12%)
Query: 27 SLQDAEWYWGDISREEVNEKLRDTA-DGTFLVRDASTKMHGDYTLTL-------RKGGNN 78
S++ EWY ++R + + L+ +G F+VRD+S G YT+++ +G
Sbjct: 275 SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKA--GKYTVSVFAKSTGDPQGVIR 332
Query: 79 KLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQD 134
+ +Y ++ FS++ ELIN++++ S L +L YPVS+ ++
Sbjct: 333 HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAG-----LISRLKYPVSQQNKN 383
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 55.1 bits (131), Expect = 1e-07
Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 14/114 (12%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
WYWG I+R E KL + DG+FLVRD+S + +L+ R G +I H +G++ F
Sbjct: 384 WYWGPITRWEAEGKLANVPDGSFLVRDSSDDRY-LLSLSFRSHGKTLHTRIEHSNGRFSF 442
Query: 93 ---SDPLTFSSVVELINH----YRNESLAQYNPKL------DVKLLYPVSKYQQ 133
D +S+V+LI H N + +L V+L PVS++ Q
Sbjct: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
Score = 30.8 bits (68), Expect = 2.4
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 314 EDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESS-KQGCYACSVVVDGEVKHCVI 372
E+L ++ W G R +AE L DG+FLVR+SS + + S G+ H I
Sbjct: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
Query: 373 NKTATGYGFAEPYNL--YSSLKELVLH 397
+ + F E ++ ++S+ +L+ H
Sbjct: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEH 460
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
++ +W G +R+ AE LL +G+FLVRES S G + S+ +G V H IN TA G
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 213
Query: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ + +S+L ELV H+ + D L TL YP
Sbjct: 214 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 247
Score = 42.4 bits (98), Expect = 8e-04
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGG 76
V +N + SL+ WY G +SR L +G+FLVR+ S G +++LR G
Sbjct: 142 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE-SESSPGQLSISLRYEG 200
Query: 77 NNKLIKIFH------RDGKYGFSDPLTFSSVVELINHY 108
+++H DGK + FS++ EL++H+
Sbjct: 201 -----RVYHYRINTTADGKVYVTAESRFSTLAELVHHH 233
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
++ +W G +R+ AE LL +G+FLVRES S G + S+ +G V H IN TA G
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 228
Query: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ + +S+L ELV H+ + D L TL YP
Sbjct: 229 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 262
Score = 42.4 bits (98), Expect = 8e-04
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGG 76
V +N + SL+ WY G +SR L +G+FLVR+ S G +++LR G
Sbjct: 157 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE-SESSPGQLSISLRYEG 215
Query: 77 NNKLIKIFH------RDGKYGFSDPLTFSSVVELINHY 108
+++H DGK + FS++ EL++H+
Sbjct: 216 -----RVYHYRINTTADGKVYVTAESRFSTLAELVHHH 248
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
++ +W G +R+ AE LL +G+FLVRES S G + S+ +G V H IN TA G
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 207
Query: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ + +S+L ELV H+ + D L TL YP
Sbjct: 208 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 241
Score = 42.4 bits (98), Expect = 8e-04
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGG 76
V +N + SL+ WY G +SR L +G+FLVR+ S G +++LR G
Sbjct: 136 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE-SESSPGQLSISLRYEG 194
Query: 77 NNKLIKIFH------RDGKYGFSDPLTFSSVVELINHY 108
+++H DGK + FS++ EL++H+
Sbjct: 195 -----RVYHYRINTTADGKVYVTAESRFSTLAELVHHH 227
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
++ +W G +R+ AE LL +G+FLVRES S G + S+ +G V H IN TA G
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 213
Query: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ + +S+L ELV H+ + D L TL YP
Sbjct: 214 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 247
Score = 42.4 bits (98), Expect = 8e-04
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGG 76
V +N + SL+ WY G +SR L +G+FLVR+ S G +++LR G
Sbjct: 142 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE-SESSPGQLSISLRYEG 200
Query: 77 NNKLIKIFH------RDGKYGFSDPLTFSSVVELINHY 108
+++H DGK + FS++ EL++H+
Sbjct: 201 -----RVYHYRINTTADGKVYVTAESRFSTLAELVHHH 233
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
++ +W G +R+ AE LL +G+FLVRES S G + S+ +G V H IN TA G
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 192
Query: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 417
+ + +S+L ELV H+ + D L TL YP
Sbjct: 193 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 226
Score = 42.4 bits (98), Expect = 8e-04
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 12/98 (12%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGG 76
V +N + SL+ WY G +SR L +G+FLVR+ S G +++LR G
Sbjct: 121 VPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRE-SESSPGQLSISLRYEG 179
Query: 77 NNKLIKIFH------RDGKYGFSDPLTFSSVVELINHY 108
+++H DGK + FS++ EL++H+
Sbjct: 180 -----RVYHYRINTTADGKVYVTAESRFSTLAELVHHH 212
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 53.5 bits (127), Expect = 4e-07
Identities = 30/99 (30%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
W+ G IS +E ++L+ DG FLVR+ S + GDY L + G + ++ HRDG
Sbjct: 81 WFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI 139
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKY 131
+ + F ++++++ HY + A + KL+ P K+
Sbjct: 140 DEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKH 173
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 53.5 bits (127), Expect = 4e-07
Identities = 30/99 (30%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
W+ G IS +E ++L+ DG FLVR+ S + GDY L + G + ++ HRDG
Sbjct: 123 WFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI 181
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKY 131
+ + F ++++++ HY + A + KL+ P K+
Sbjct: 182 DEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKH 215
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 53.5 bits (127), Expect = 4e-07
Identities = 30/99 (30%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
W+ G IS +E ++L+ DG FLVR+ S + GDY L + G + ++ HRDG
Sbjct: 122 WFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI 180
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKY 131
+ + F ++++++ HY + A + KL+ P K+
Sbjct: 181 DEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKH 214
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 53.5 bits (127), Expect = 4e-07
Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 2/101 (1%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSKQG-CYACSVVVDGEVKHCVINKTATGYGFA 382
W G+ R + +NLL+ GT+L+RE + +A S+ + EVKH + +
Sbjct: 673 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 732
Query: 383 EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
E + SL ELV +YQ SL + L+ TL YP +++R
Sbjct: 733 EA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRER 772
Score = 52.4 bits (124), Expect = 8e-07
Identities = 25/95 (26%), Positives = 52/95 (54%), Gaps = 1/95 (1%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
W+ G++ R++ + L+ A GT+L+R+ + + ++++ K IK+ +D
Sbjct: 673 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAER-FAISIKFNDEVKHIKVVEKDNWIHI 731
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYP 127
++ F S++EL+ +Y+ SL + +LD L YP
Sbjct: 732 TEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYP 766
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 53.5 bits (127), Expect = 4e-07
Identities = 33/101 (32%), Positives = 52/101 (51%), Gaps = 2/101 (1%)
Query: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESSKQG-CYACSVVVDGEVKHCVINKTATGYGFA 382
W G+ R + +NLL+ GT+L+RE + +A S+ + EVKH + +
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 722
Query: 383 EPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
E + SL ELV +YQ SL + L+ TL YP +++R
Sbjct: 723 EA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRER 762
Score = 52.4 bits (124), Expect = 8e-07
Identities = 25/95 (26%), Positives = 52/95 (54%), Gaps = 1/95 (1%)
Query: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
W+ G++ R++ + L+ A GT+L+R+ + + ++++ K IK+ +D
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAER-FAISIKFNDEVKHIKVVEKDNWIHI 721
Query: 93 SDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYP 127
++ F S++EL+ +Y+ SL + +LD L YP
Sbjct: 722 TEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYP 756
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 52.4 bits (124), Expect = 8e-07
Identities = 40/171 (23%), Positives = 79/171 (46%), Gaps = 25/171 (14%)
Query: 254 AEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTED-------- 305
A+Y K++ +P+ R+ + W + ++ +E + + N ++
Sbjct: 214 AQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTS 273
Query: 306 -------QYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGK-RDGTFLVRESSKQGCY 357
+ S E++E+L +D W G+ +R+++E LLR K ++G F+VR SS+ G Y
Sbjct: 274 KISWEFPESSSSEEEENLDDYD---WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMY 330
Query: 358 ACSVV------VDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTS 402
S+ G VKH ++ A + + S+ +L+ ++QH S
Sbjct: 331 TVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNS 381
Score = 42.0 bits (97), Expect = 0.001
Identities = 33/111 (29%), Positives = 61/111 (54%), Gaps = 15/111 (13%)
Query: 27 SLQDAEWYWGDISREEVNEKLRDTA-DGTFLVRDASTKMHGDYTLTL-RKGGNNK--LIK 82
+L D +W+ G+ISR + + LR +G F+VR++S G YT++L K N+K +K
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSS--QVGMYTVSLFSKAVNDKKGTVK 347
Query: 83 IFH----RDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVS 129
+H + K ++ F S+ +LI+++++ S + +L +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAG-----MITRLRHPVS 393
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 52.4 bits (124), Expect = 8e-07
Identities = 40/171 (23%), Positives = 79/171 (46%), Gaps = 25/171 (14%)
Query: 254 AEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTED-------- 305
A+Y K++ +P+ R+ + W + ++ +E + + N ++
Sbjct: 214 AQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTS 273
Query: 306 -------QYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGK-RDGTFLVRESSKQGCY 357
+ S E++E+L +D W G+ +R+++E LLR K ++G F+VR SS+ G Y
Sbjct: 274 KISWEFPESSSSEEEENLDDYD---WFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMY 330
Query: 358 ACSVV------VDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTS 402
S+ G VKH ++ A + + S+ +L+ ++QH S
Sbjct: 331 TVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNS 381
Score = 42.0 bits (97), Expect = 0.001
Identities = 33/111 (29%), Positives = 61/111 (54%), Gaps = 15/111 (13%)
Query: 27 SLQDAEWYWGDISREEVNEKLRDTA-DGTFLVRDASTKMHGDYTLTL-RKGGNNK--LIK 82
+L D +W+ G+ISR + + LR +G F+VR++S G YT++L K N+K +K
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSS--QVGMYTVSLFSKAVNDKKGTVK 347
Query: 83 IFH----RDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVS 129
+H + K ++ F S+ +LI+++++ S + +L +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAG-----MITRLRHPVS 393
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 52.4 bits (124), Expect = 8e-07
Identities = 37/130 (28%), Positives = 69/130 (53%), Gaps = 9/130 (6%)
Query: 17 VANNGMNNNMSLQDAEWYWGDISREEVNEKLR--DTADGTFLVRDASTKMHGDYTLTLRK 74
V +N + +++ W++G ISR E +L+ A G FL+R S K DY L++R
Sbjct: 62 VPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIR-VSEKPSADYVLSVRD 120
Query: 75 GGNNKLIKIFHR-DGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ 133
+ KI+ R G+ ++ ++F S+ EL+N++R +SL+ ++L P K++
Sbjct: 121 TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSH-----GLRLAAPCRKHEP 175
Query: 134 DQVVKEDNIE 143
+ + D+ E
Sbjct: 176 EPLPHWDDWE 185
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 52.4 bits (124), Expect = 8e-07
Identities = 44/159 (27%), Positives = 77/159 (48%), Gaps = 16/159 (10%)
Query: 267 KPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNV 326
+P + LR+ ++YL+ L + K + LGNE + E+ + + + W
Sbjct: 97 EPCNLALRRA-EEYLI-LEKYNPHWWKARDRLGNEGLIPSNYVTENK--ITNLEIYEWYH 152
Query: 327 GSSNRNKAENLLRGK-RDGTFLVRESSKQGCYACSVVV------DGEVKHCVINKTATGY 379
+ RN+AE+LLR + ++G F+VR+S G Y SV + + +KH I K +G
Sbjct: 153 RNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQ 212
Query: 380 GFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 418
+ + + S+ EL+ ++QH + L L YPV
Sbjct: 213 WYVAERHAFQSIPELIWYHQHNAA-----GLMTRLRYPV 246
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
1 [Homo sapiens]
Length = 1722
Score = 52.4 bits (124), Expect = 8e-07
Identities = 63/243 (25%), Positives = 112/243 (46%), Gaps = 42/243 (17%)
Query: 119 KLDVKLLYPVSKYQQD----QVVKEDNI--------EAVGKKLH----EYNTQFQEKS-R 161
K++ K L + K +QD ++ KE+ I E + LH E T+F+++ +
Sbjct: 215 KVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
Query: 162 EYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKF-----KREG 216
E + L ++ + +IQ K A A+ + I +EQ ++++R ++E+ EK K E
Sbjct: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
Query: 217 NEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYRE-----IDKRMNSIKPDLI 271
N K ++ + RI E + +++ EE+ K++ EY E +R I + I
Sbjct: 335 NRKRLEE--------EQRIKE--ERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKI 384
Query: 272 QLRKTRDQYLM---WLTQKGVRQKKLN-EWLGNENTEDQYSLVEDDEDLPHHDEKTWNVG 327
LR+ Q L+ L + G K L+ E + N+ + +LV D+ D W V
Sbjct: 385 ILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLV-DENSKKQEDVLLWLVE 443
Query: 328 SSN 330
SN
Sbjct: 444 ESN 446
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform
2 [Homo sapiens]
Length = 1336
Score = 52.4 bits (124), Expect = 8e-07
Identities = 63/243 (25%), Positives = 112/243 (46%), Gaps = 42/243 (17%)
Query: 119 KLDVKLLYPVSKYQQD----QVVKEDNI--------EAVGKKLH----EYNTQFQEKS-R 161
K++ K L + K +QD ++ KE+ I E + LH E T+F+++ +
Sbjct: 215 KVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
Query: 162 EYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKF-----KREG 216
E + L ++ + +IQ K A A+ + I +EQ ++++R ++E+ EK K E
Sbjct: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE 334
Query: 217 NEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYRE-----IDKRMNSIKPDLI 271
N K ++ + RI E + +++ EE+ K++ EY E +R I + I
Sbjct: 335 NRKRLEE--------EQRIKE--ERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKI 384
Query: 272 QLRKTRDQYLM---WLTQKGVRQKKLN-EWLGNENTEDQYSLVEDDEDLPHHDEKTWNVG 327
LR+ Q L+ L + G K L+ E + N+ + +LV D+ D W V
Sbjct: 385 ILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLV-DENSKKQEDVLLWLVE 443
Query: 328 SSN 330
SN
Sbjct: 444 ESN 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,791,130
Number of Sequences: 37866
Number of extensions: 707014
Number of successful extensions: 4332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 144
Number of HSP's successfully gapped in prelim test: 543
Number of HSP's that attempted gapping in prelim test: 2994
Number of HSP's gapped (non-prelim): 1551
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.