Guide to the Human Genome
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Search of human proteins with 32307163

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
         (465 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      961   0.0  
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       929   0.0  
gi|62241015 AKT1 kinase [Homo sapiens]                                776   0.0  
gi|62241013 AKT1 kinase [Homo sapiens]                                776   0.0  
gi|62241011 AKT1 kinase [Homo sapiens]                                776   0.0  
gi|4502023 AKT2 kinase [Homo sapiens]                                 744   0.0  
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   348   6e-96
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   348   6e-96
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   348   6e-96
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   348   6e-96
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   342   4e-94
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   341   7e-94
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   333   2e-91
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           333   2e-91
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   331   7e-91
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   331   7e-91
gi|28557781 protein kinase C, eta [Homo sapiens]                      323   2e-88
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           320   2e-87
gi|4506067 protein kinase C, alpha [Homo sapiens]                     316   2e-86
gi|133908623 protein kinase C, iota [Homo sapiens]                    313   2e-85
gi|5453974 protein kinase N2 [Homo sapiens]                           313   2e-85
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                308   7e-84
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                308   7e-84
gi|13384594 protein kinase C, gamma [Homo sapiens]                    305   7e-83
gi|5453976 protein kinase C, theta [Homo sapiens]                     298   7e-81
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           298   9e-81
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           298   9e-81
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           298   9e-81
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   295   5e-80
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   295   5e-80

>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  961 bits (2484), Expect = 0.0
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
           MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
Sbjct: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60

Query: 61  LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
           LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
Sbjct: 61  LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120

Query: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
           PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
Sbjct: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180

Query: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
           KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
Sbjct: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240

Query: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
           RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
Sbjct: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300

Query: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
           ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
Sbjct: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360

Query: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
           EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
Sbjct: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420

Query: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465
           PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK
Sbjct: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  929 bits (2402), Expect = 0.0
 Identities = 452/465 (97%), Positives = 456/465 (98%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
           MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
Sbjct: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60

Query: 61  LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
           LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
Sbjct: 61  LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120

Query: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
           PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
Sbjct: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180

Query: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
           KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
Sbjct: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240

Query: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
           RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
Sbjct: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300

Query: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
           ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
Sbjct: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360

Query: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
           EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
Sbjct: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420

Query: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465
           PFKPQVTSETDTRYFDEEFTAQTITITPPEK  +     + N ++
Sbjct: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERR 465


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  776 bits (2004), Expect = 0.0
 Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
           MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD    PLNNFSVA+C
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 60  QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
           QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ 
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
              S  DN G EEM+ S    K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
           LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
           RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
            D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
           ILME+I+FPRTL  +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
           L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++    +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  776 bits (2004), Expect = 0.0
 Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
           MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD    PLNNFSVA+C
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 60  QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
           QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ 
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
              S  DN G EEM+ S    K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
           LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
           RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
            D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
           ILME+I+FPRTL  +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
           L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++    +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  776 bits (2004), Expect = 0.0
 Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
           MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD    PLNNFSVA+C
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 60  QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
           QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ 
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
              S  DN G EEM+ S    K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
           LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
           RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
            D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
           ILME+I+FPRTL  +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
           L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++    +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  744 bits (1922), Expect = 0.0
 Identities = 358/456 (78%), Positives = 409/456 (89%), Gaps = 6/456 (1%)

Query: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQ--DVDLPYPLNNFSVAK 58
           M++V+++KEGW+ KRGEYIK WRPRYFLLK+DGSFIGYKE+P+  D  LP PLNNFSVA+
Sbjct: 1   MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLP-PLNNFSVAE 59

Query: 59  CQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQE--EER 116
           CQLMKTERP+PNTF+IRCLQWTTVIERTFHVD+P+EREEW  AIQ VA+ L+++   E+ 
Sbjct: 60  CQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDP 119

Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
           M+    S  D+   EEM+ + +  + K TMNDFDYLKLLGKGTFGKVILVREKA+G+YYA
Sbjct: 120 MDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYA 179

Query: 176 MKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
           MKIL+KEVIIAKDEVAHT+TESRVL+NTRHPFLT+LKY+FQT DRLCFVMEY NGGELFF
Sbjct: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239

Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
           HLSRERVF+E+R RFYGAEIVSAL+YLHS  +VYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299

Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
           GI+D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359

Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
           ELILME+I+FPRTLS +AKSLL+GLL KDP +RLGGGP DAKE+M H FF  +NWQDV  
Sbjct: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419

Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451
           KKL+PPFKPQVTSE DTRYFD+EFTAQ+ITITPP++
Sbjct: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDR 455


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  348 bits (893), Expect = 6e-96
 Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)

Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
           +Q++    Q QE E MN +P+       +  +  S+  H + +  DF +LK++GKG+FGK
Sbjct: 54  VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111

Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
           V+L R KA   +YA+K+L+K+ I+ K E  H ++E  VL KN +HPFL  L +SFQT D+
Sbjct: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171

Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
           L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS  IVYRDLK EN++LD
Sbjct: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231

Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
             GHI +TDFGLCKE I   +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+
Sbjct: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291

Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
            G  PFY+++  ++++ IL + ++    +++ A+ LL GLL KD  KRL G  DD  EI 
Sbjct: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350

Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
            H FFS +NW D+ +KK+ PPF P V+   D R+FD EFT + +
Sbjct: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 394


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  348 bits (893), Expect = 6e-96
 Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)

Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
           +Q++    Q QE E MN +P+       +  +  S+  H + +  DF +LK++GKG+FGK
Sbjct: 68  VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 125

Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
           V+L R KA   +YA+K+L+K+ I+ K E  H ++E  VL KN +HPFL  L +SFQT D+
Sbjct: 126 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 185

Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
           L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS  IVYRDLK EN++LD
Sbjct: 186 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 245

Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
             GHI +TDFGLCKE I   +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+
Sbjct: 246 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 305

Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
            G  PFY+++  ++++ IL + ++    +++ A+ LL GLL KD  KRL G  DD  EI 
Sbjct: 306 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 364

Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
            H FFS +NW D+ +KK+ PPF P V+   D R+FD EFT + +
Sbjct: 365 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 408


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  348 bits (893), Expect = 6e-96
 Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)

Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
           +Q++    Q QE E MN +P+       +  +  S+  H + +  DF +LK++GKG+FGK
Sbjct: 82  VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139

Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
           V+L R KA   +YA+K+L+K+ I+ K E  H ++E  VL KN +HPFL  L +SFQT D+
Sbjct: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199

Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
           L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS  IVYRDLK EN++LD
Sbjct: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259

Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
             GHI +TDFGLCKE I   +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+
Sbjct: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319

Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
            G  PFY+++  ++++ IL + ++    +++ A+ LL GLL KD  KRL G  DD  EI 
Sbjct: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378

Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
            H FFS +NW D+ +KK+ PPF P V+   D R+FD EFT + +
Sbjct: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 422


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  348 bits (893), Expect = 6e-96
 Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)

Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
           +Q++    Q QE E MN +P+       +  +  S+  H + +  DF +LK++GKG+FGK
Sbjct: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206

Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
           V+L R KA   +YA+K+L+K+ I+ K E  H ++E  VL KN +HPFL  L +SFQT D+
Sbjct: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266

Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
           L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS  IVYRDLK EN++LD
Sbjct: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326

Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
             GHI +TDFGLCKE I   +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+
Sbjct: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386

Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
            G  PFY+++  ++++ IL + ++    +++ A+ LL GLL KD  KRL G  DD  EI 
Sbjct: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445

Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
            H FFS +NW D+ +KK+ PPF P V+   D R+FD EFT + +
Sbjct: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 489


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  342 bits (877), Expect = 4e-94
 Identities = 170/334 (50%), Positives = 222/334 (66%), Gaps = 5/334 (1%)

Query: 116 RMNCSPT---SQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
           RMN SP    S   +     ++   + +      DFD+LK++GKG +GKV+L + K+ G 
Sbjct: 60  RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119

Query: 173 YYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
           +YA+K+L+K+ I+ K E +H + E  VL KN RHPFL  L+YSFQT ++L FV++YVNGG
Sbjct: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGG 179

Query: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
           ELFFHL RER F E R RFY AE+ SA+ YLHS  I+YRDLK EN++LD  GH+ +TDFG
Sbjct: 180 ELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG 239

Query: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 351
           LCKEG+    T  TFCGTPEYLAPEVL    Y RAVDWW LG V+YEM+ G  PFY+QD 
Sbjct: 240 LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDV 299

Query: 352 EKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQ 411
            +++E IL + ++ P   +  A  LL  LL KD  +RL G   D  EI  H FFS +NW 
Sbjct: 300 SQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWD 358

Query: 412 DVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
           D+Y K+L PPF P VT   D ++FD EFT + ++
Sbjct: 359 DLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  341 bits (875), Expect = 7e-94
 Identities = 164/300 (54%), Positives = 211/300 (70%), Gaps = 2/300 (0%)

Query: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRH 205
           DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K+ I+ K E +H + E  VL KN RH
Sbjct: 34  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93

Query: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
           PFL  L+YSFQT ++L FV++YVNGGELFFHL RER F E R RFY AE+ SA+ YLHS 
Sbjct: 94  PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153

Query: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
            I+YRDLK EN++LD  GH+ +TDFGLCKEG+    T  TFCGTPEYLAPEVL    Y R
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213

Query: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
           AVDWW LG V+YEM+ G  PFY+QD  +++E IL + ++ P   +  A  LL  LL KD 
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273

Query: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
            +RL G   D  EI  H FFS +NW D+Y K+L PPF P VT   D ++FD EFT + ++
Sbjct: 274 RQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  333 bits (855), Expect = 2e-91
 Identities = 165/358 (46%), Positives = 236/358 (65%), Gaps = 4/358 (1%)

Query: 93  EEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLK 152
           +E +E    I+       R EE R   SP  Q+ + GE   +      KR  +++F+++K
Sbjct: 354 QEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENG-EVRQGQAKRLGLDEFNFIK 412

Query: 153 LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSL 211
           +LGKG+FGKV+L   K   + YA+K+LKK+VI+  D+V  T+TE R+L   R HP+LT L
Sbjct: 413 VLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQL 472

Query: 212 KYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRD 271
              FQTKDRL FVMEYVNGG+L F + R R F E R+RFY AE+ SAL +LH   ++YRD
Sbjct: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532

Query: 272 LKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 331
           LKL+N++LD +GH K+ DFG+CKEGI +  T  TFCGTP+Y+APE+L++ +YG +VDWW 
Sbjct: 533 LKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWA 592

Query: 332 LGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLG- 390
           LGV+MYEMM G+ PF   + + LFE IL +D+ +P  LS +A S+L   + K+P+KRLG 
Sbjct: 593 LGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGC 652

Query: 391 -GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITIT 447
               +    I +H FF  ++W  +  KK+ PPFKP++ ++ D   FD++FT +   +T
Sbjct: 653 VASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLT 710


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  333 bits (855), Expect = 2e-91
 Identities = 162/370 (43%), Positives = 237/370 (64%), Gaps = 14/370 (3%)

Query: 87  FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142
           F+V  P E  E  E ++   +R +  +     E    +  S+ DN G  +         R
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336

Query: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202
             + DF++L +LGKG+FGKV+L   K + + YA+KILKK+V+I  D+V  T+ E RVL  
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396

Query: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261
             + PFLT L   FQT DRL FVMEYVNGG+L +H+ +   F E    FY AEI   L +
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456

Query: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
           L S  I+YRDLKL+N+MLD +GHIKI DFG+CKE I D  T KTFCGTP+Y+APE++   
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516

Query: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381
            YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+  ++ +P+++S +A ++  GL+
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576

Query: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441
            K P KRLG GP+  ++I  H+FF  ++W+ +  K++ PP+KP+   + DT  FD+EFT 
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTR 636

Query: 442 QTITITPPEK 451
           Q + +TP +K
Sbjct: 637 QPVELTPTDK 646


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  331 bits (849), Expect = 7e-91
 Identities = 180/401 (44%), Positives = 240/401 (59%), Gaps = 26/401 (6%)

Query: 62  MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
           +K  R   N FI   +++  +     +     +D+P+ + + +E            E   
Sbjct: 87  IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137

Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
                TSQ  N+G      S   H + T  DFD+LK++GKG+FGKV+L + K  GK+YA+
Sbjct: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190

Query: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
           K+L+K++++ + E  H + E  VL KN +HPFL  L YSFQT ++L FV+++VNGGELFF
Sbjct: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250

Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
           HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD  GH+ +TDFGLCKE
Sbjct: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310

Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
           GI  + T  TFCGTPEYLAPEV+    Y   VDWW LG V+YEM+ G  PFY +D  +++
Sbjct: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370

Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
           + IL + +     +S  A S+L  LL KD   RL G  +D  EI  H FF  ++W D+  
Sbjct: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429

Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
           KK+ PPF P V    D R FD  FT +T+   P   C  SD
Sbjct: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 467


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  331 bits (849), Expect = 7e-91
 Identities = 180/401 (44%), Positives = 240/401 (59%), Gaps = 26/401 (6%)

Query: 62  MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
           +K  R   N FI   +++  +     +     +D+P+ + + +E            E   
Sbjct: 87  IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137

Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
                TSQ  N+G      S   H + T  DFD+LK++GKG+FGKV+L + K  GK+YA+
Sbjct: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190

Query: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
           K+L+K++++ + E  H + E  VL KN +HPFL  L YSFQT ++L FV+++VNGGELFF
Sbjct: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250

Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
           HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD  GH+ +TDFGLCKE
Sbjct: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310

Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
           GI  + T  TFCGTPEYLAPEV+    Y   VDWW LG V+YEM+ G  PFY +D  +++
Sbjct: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370

Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
           + IL + +     +S  A S+L  LL KD   RL G  +D  EI  H FF  ++W D+  
Sbjct: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429

Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
           KK+ PPF P V    D R FD  FT +T+   P   C  SD
Sbjct: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 467


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  323 bits (829), Expect = 2e-88
 Identities = 155/343 (45%), Positives = 223/343 (65%), Gaps = 12/343 (3%)

Query: 118 NCSPTSQI----------DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVRE 167
           N SPTS++              +E          R  +++F+++++LGKG+FGKV+L R 
Sbjct: 315 NISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARV 374

Query: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLKYSFQTKDRLCFVME 226
           K +G  YA+K+LKK+VI+  D+V  T+TE R+L   R HPFLT L   FQT DRL FVME
Sbjct: 375 KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVME 434

Query: 227 YVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIK 286
           +VNGG+L FH+ + R F E R RFY AEI+SAL +LH   I+YRDLKL+N++LD +GH K
Sbjct: 435 FVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCK 494

Query: 287 ITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
           + DFG+CKEGI +  T  TFCGTP+Y+APE+L++  YG AVDWW +GV++YEM+CG  PF
Sbjct: 495 LADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF 554

Query: 347 YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKE-IMRHSFF 405
             ++ + LFE IL +++ +P  L  DA  +L   + K+P  RLG      +  I+RH FF
Sbjct: 555 EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 614

Query: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
             ++W  +  +++ PPF+P++ S  D   FD +F  +   +TP
Sbjct: 615 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTP 657


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  320 bits (819), Expect = 2e-87
 Identities = 158/370 (42%), Positives = 232/370 (62%), Gaps = 15/370 (4%)

Query: 87  FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142
           F+V  P E  E  E ++   +R +  +     E    +  S+ DN G  +         R
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336

Query: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202
             + DF++L +LGKG+FGKV+L   K + + YA+KILKK+V+I  D+V  T+ E RVL  
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396

Query: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261
             + PFLT L   FQT DRL FVMEYVNGG+L +H+ +   F E    FY AEI   L +
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456

Query: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
           L S  I+YRDLKL+N+MLD +GHIKI DFG+CKE I D  T KTFCGTP+Y+APE++   
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516

Query: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381
            YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+  ++ +P+++S +A ++  GL+
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576

Query: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441
            K P KRLG GP+  ++I  H+FF  ++W+ +  K++ PP+KP+     +   FD  FT 
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635

Query: 442 QTITITPPEK 451
               +TPP++
Sbjct: 636 HPPVLTPPDQ 645


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  316 bits (810), Expect = 2e-86
 Identities = 156/366 (42%), Positives = 233/366 (63%), Gaps = 10/366 (2%)

Query: 87  FHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMN 146
           ++V  PE  EE    +        RQ+ E+    P         E+    + +  R  + 
Sbjct: 286 YNVPIPEGDEEGNMEL--------RQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337

Query: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-RH 205
           DF++L +LGKG+FGKV+L   K + + YA+KILKK+V+I  D+V  T+ E RVL    + 
Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397

Query: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
           PFLT L   FQT DRL FVMEYVNGG+L +H+ +   F E +  FY AEI   L +LH  
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457

Query: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
            I+YRDLKL+N+MLD +GHIKI DFG+CKE + D  T +TFCGTP+Y+APE++    YG+
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517

Query: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
           +VDWW  GV++YEM+ G+ PF  +D ++LF+ I+  ++ +P++LS +A S+  GL+ K P
Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577

Query: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
            KRLG GP+  +++  H+FF  ++W+ + ++++ PPFKP+V  +     FD+ FT     
Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPV 636

Query: 446 ITPPEK 451
           +TPP++
Sbjct: 637 LTPPDQ 642


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  313 bits (803), Expect = 2e-85
 Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)

Query: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172
           N S    +D +GEE+ +A  T    K      + DFD L+++G+G++ KV+LVR K + +
Sbjct: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278

Query: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
            YAMK++KKE++   +++    TE  V +  + HPFL  L   FQT+ RL FV+EYVNGG
Sbjct: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338

Query: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
           +L FH+ R+R   E+  RFY AEI  AL+YLH   I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398

Query: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346
           +CKEG+    T  TFCGTP Y+APE+L   DYG +VDWW LGV+M+EMM GR PF     
Sbjct: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458

Query: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401
             N D    + LF++IL + I+ PR+LS  A S+L   L KDP +RLG  P     +I  
Sbjct: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518

Query: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450
           H FF  V+W  +  K++VPPFKP ++ E     FD +FT + + +TP +
Sbjct: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  313 bits (803), Expect = 2e-85
 Identities = 154/347 (44%), Positives = 226/347 (65%), Gaps = 5/347 (1%)

Query: 109 LQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVRE 167
           L + + E    +P S ++  G +E++   +  + +  + DF    +LG+G FGKV+L   
Sbjct: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676

Query: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK---NTRHPFLTSLKYSFQTKDRLCFV 224
           K + + +A+K LKK  I+A+DEV   + E R+ +   + RHPFL +L   FQTK+ +CFV
Sbjct: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736

Query: 225 MEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGH 284
           MEY  GG+L  H+  + VFSE R  FY A +V  L YLH  KIVYRDLKL+NL+LD +G 
Sbjct: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF 795

Query: 285 IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344
           +KI DFGLCKEG+       TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G  
Sbjct: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855

Query: 345 PFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSF 404
           PF   D E++F+ I+ +++++PR LS++A S++  LL ++P +RLG    DA+++ +H F
Sbjct: 856 PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 915

Query: 405 FSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451
           F  ++W  + DKK+ PPF P +    D   FD+EFT++   +TPP +
Sbjct: 916 FRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE 962


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  308 bits (789), Expect = 7e-84
 Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)

Query: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
           T+ DF +L +LG+G FGKV+L   + SG+ +A+K LKK  I+A+DEV   + E R+L   
Sbjct: 617 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 676

Query: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
            +  HPFL +L   FQT + +CFVMEY  GG+L  H+  + VFSE R  FY A +V  L 
Sbjct: 677 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 735

Query: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
           +LH  KIVYRDLKL+NL+LD +G++KI DFGLCKEG+       TFCGTPE+LAPEVL D
Sbjct: 736 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 795

Query: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
             Y RAVDWWGLGV++YEM+ G  PF   D E++F+ I+ +++++PR LS++A  ++  L
Sbjct: 796 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 855

Query: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
           L ++P +RLG    DA+++ +  FF  + W+ +  ++L PPF P ++  TD   FDEEFT
Sbjct: 856 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 915

Query: 441 AQTITITPP 449
            +  T++PP
Sbjct: 916 GEAPTLSPP 924


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  308 bits (789), Expect = 7e-84
 Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)

Query: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
           T+ DF +L +LG+G FGKV+L   + SG+ +A+K LKK  I+A+DEV   + E R+L   
Sbjct: 611 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 670

Query: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
            +  HPFL +L   FQT + +CFVMEY  GG+L  H+  + VFSE R  FY A +V  L 
Sbjct: 671 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 729

Query: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
           +LH  KIVYRDLKL+NL+LD +G++KI DFGLCKEG+       TFCGTPE+LAPEVL D
Sbjct: 730 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 789

Query: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
             Y RAVDWWGLGV++YEM+ G  PF   D E++F+ I+ +++++PR LS++A  ++  L
Sbjct: 790 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 849

Query: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
           L ++P +RLG    DA+++ +  FF  + W+ +  ++L PPF P ++  TD   FDEEFT
Sbjct: 850 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 909

Query: 441 AQTITITPP 449
            +  T++PP
Sbjct: 910 GEAPTLSPP 918


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  305 bits (780), Expect = 7e-83
 Identities = 146/316 (46%), Positives = 207/316 (65%), Gaps = 7/316 (2%)

Query: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK 201
           R  ++DF +L +LGKG+FGKV+L   + S + YA+KILKK+VI+  D+V  TL E RVL 
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 202 ------NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
                   R  FLT L  +FQT DRL FVMEYV GG+L +H+ +   F E    FY AEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
              L +LH+  I+YRDLKL+N+MLD +GHIKITDFG+CKE +    T +TFCGTP+Y+AP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524

Query: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
           E++    YG++VDWW  GV++YEM+ G+ PF  +D E+LF+ I+ + + +P++LS +A +
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584

Query: 376 LLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
           +  G L K P KRLG GPD    I  H FF  ++W+ +   ++ PPF+P+    +    F
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN-F 643

Query: 436 DEEFTAQTITITPPEK 451
           D+ FT     +TPP++
Sbjct: 644 DKFFTRAAPALTPPDR 659


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  298 bits (763), Expect = 7e-81
 Identities = 150/325 (46%), Positives = 211/325 (64%), Gaps = 9/325 (2%)

Query: 120 SPTSQID---NIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
           SP  ++D   ++ E E++      + K  + DF   K+LGKG+FGKV L   K + +++A
Sbjct: 348 SPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407

Query: 176 MKILKKEVIIAKDEVAHTLTESRVLKNT-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234
           +K LKK+V++  D+V  T+ E RVL     HPFLT +  +FQTK+ L FVMEY+NGG+L 
Sbjct: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467

Query: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
           +H+     F   R  FY AEI+  L +LHS  IVYRDLKL+N++LDKDGHIKI DFG+CK
Sbjct: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527

Query: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
           E +   A   TFCGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+L
Sbjct: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587

Query: 355 FELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVY 414
           F  I M++  +PR L  +AK LL  L +++P KRLG   D    I +H  F  +NW+++ 
Sbjct: 588 FHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELE 643

Query: 415 DKKLVPPFKPQVTSETDTRYFDEEF 439
            K++ PPF+P+V S  D   FD+EF
Sbjct: 644 RKEIDPPFRPKVKSPFDCSNFDKEF 668


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  298 bits (762), Expect = 9e-81
 Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)

Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
           + DFD ++++G+G++ KV+LVR K + + YAMK++KKE++   +++    TE  V +  +
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
            +PFL  L   FQT  RL  V+EYVNGG+L FH+ R+R   E+  RFY AEI  AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
              I+YRDLKL+N++LD DGHIK+TD+G+CKEG+    T  TFCGTP Y+APE+L   +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + I+ PR LS  A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
           L G L KDP +RLG  P     +I  H+FF  ++W  +  K+ +PPF+PQ+T +     F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 436 DEEFTAQTITITPPEK 451
           D +FT++ + +TP ++
Sbjct: 366 DTQFTSEPVQLTPDDE 381


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  298 bits (762), Expect = 9e-81
 Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)

Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
           + DFD ++++G+G++ KV+LVR K + + YAMK++KKE++   +++    TE  V +  +
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
            +PFL  L   FQT  RL  V+EYVNGG+L FH+ R+R   E+  RFY AEI  AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
              I+YRDLKL+N++LD DGHIK+TD+G+CKEG+    T  TFCGTP Y+APE+L   +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + I+ PR LS  A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
           L G L KDP +RLG  P     +I  H+FF  ++W  +  K+ +PPF+PQ+T +     F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 436 DEEFTAQTITITPPEK 451
           D +FT++ + +TP ++
Sbjct: 366 DTQFTSEPVQLTPDDE 381


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  298 bits (762), Expect = 9e-81
 Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)

Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
           + DFD ++++G+G++ KV+LVR K + + YAMK++KKE++   +++    TE  V +  +
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308

Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
            +PFL  L   FQT  RL  V+EYVNGG+L FH+ R+R   E+  RFY AEI  AL++LH
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368

Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
              I+YRDLKL+N++LD DGHIK+TD+G+CKEG+    T  TFCGTP Y+APE+L   +Y
Sbjct: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428

Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + I+ PR LS  A  +
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488

Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
           L G L KDP +RLG  P     +I  H+FF  ++W  +  K+ +PPF+PQ+T +     F
Sbjct: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548

Query: 436 DEEFTAQTITITPPEK 451
           D +FT++ + +TP ++
Sbjct: 549 DTQFTSEPVQLTPDDE 564


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  295 bits (756), Expect = 5e-80
 Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)

Query: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
           + S THH     ++   + F+ LK+LG+G+FGKV LVR+     SG  YAMK+LKK  + 
Sbjct: 52  EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 111

Query: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
            +D V  T  E  +L +  HPF+  L Y+FQT+ +L  +++++ GG+LF  LS+E +F+E
Sbjct: 112 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 170

Query: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
           +  +FY AE+   LD+LHS  I+YRDLK EN++LD++GHIK+TDFGL KE I       +
Sbjct: 171 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230

Query: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
           FCGT EY+APEV+    +  + DWW  GV+M+EM+ G LPF  +D ++   LIL   +  
Sbjct: 231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 290

Query: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
           P+ LS++A+SLL  L  ++P  RLG GPD A+EI RH F+S ++W  +Y +++ PPFKP 
Sbjct: 291 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 350

Query: 426 VTSETDTRYFDEEFTAQTITITP 448
           V    DT YFD EFT++T   +P
Sbjct: 351 VAQPDDTFYFDTEFTSRTPKDSP 373



 Score =  119 bits (297), Expect = 8e-27
 Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)

Query: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
           H K    +D   +K  +G G++ +      KA+   YA+K++ K      +E+       
Sbjct: 417 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 470

Query: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
            +L+  +HP + +LK  +     +  V E + GGEL   + R++ FSE    F    I  
Sbjct: 471 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 530

Query: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
            ++YLHS  +V+RDLK  N++ +D+ G+   ++I DFG  K+   +   + T C T  ++
Sbjct: 531 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 590

Query: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
           APEVL+   Y    D W LG+++Y M+ G  PF N   +   E++  +   KF       
Sbjct: 591 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 650

Query: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
            T+S  AK L+S +L  DP++RL      AK++++H
Sbjct: 651 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  295 bits (756), Expect = 5e-80
 Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)

Query: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
           + S THH     ++   + F+ LK+LG+G+FGKV LVR+     SG  YAMK+LKK  + 
Sbjct: 43  EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 102

Query: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
            +D V  T  E  +L +  HPF+  L Y+FQT+ +L  +++++ GG+LF  LS+E +F+E
Sbjct: 103 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 161

Query: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
           +  +FY AE+   LD+LHS  I+YRDLK EN++LD++GHIK+TDFGL KE I       +
Sbjct: 162 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 221

Query: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
           FCGT EY+APEV+    +  + DWW  GV+M+EM+ G LPF  +D ++   LIL   +  
Sbjct: 222 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 281

Query: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
           P+ LS++A+SLL  L  ++P  RLG GPD A+EI RH F+S ++W  +Y +++ PPFKP 
Sbjct: 282 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 341

Query: 426 VTSETDTRYFDEEFTAQTITITP 448
           V    DT YFD EFT++T   +P
Sbjct: 342 VAQPDDTFYFDTEFTSRTPKDSP 364



 Score =  119 bits (297), Expect = 8e-27
 Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)

Query: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
           H K    +D   +K  +G G++ +      KA+   YA+K++ K      +E+       
Sbjct: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 461

Query: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
            +L+  +HP + +LK  +     +  V E + GGEL   + R++ FSE    F    I  
Sbjct: 462 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 521

Query: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
            ++YLHS  +V+RDLK  N++ +D+ G+   ++I DFG  K+   +   + T C T  ++
Sbjct: 522 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 581

Query: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
           APEVL+   Y    D W LG+++Y M+ G  PF N   +   E++  +   KF       
Sbjct: 582 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 641

Query: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
            T+S  AK L+S +L  DP++RL      AK++++H
Sbjct: 642 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,524,162
Number of Sequences: 37866
Number of extensions: 845625
Number of successful extensions: 4315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2019
Number of HSP's gapped (non-prelim): 978
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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