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Search of human proteins with 32307163
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 961 0.0
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 929 0.0
gi|62241015 AKT1 kinase [Homo sapiens] 776 0.0
gi|62241013 AKT1 kinase [Homo sapiens] 776 0.0
gi|62241011 AKT1 kinase [Homo sapiens] 776 0.0
gi|4502023 AKT2 kinase [Homo sapiens] 744 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 348 6e-96
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 348 6e-96
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 348 6e-96
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 348 6e-96
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 342 4e-94
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 341 7e-94
gi|4885563 protein kinase C, epsilon [Homo sapiens] 333 2e-91
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 333 2e-91
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 331 7e-91
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 331 7e-91
gi|28557781 protein kinase C, eta [Homo sapiens] 323 2e-88
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 320 2e-87
gi|4506067 protein kinase C, alpha [Homo sapiens] 316 2e-86
gi|133908623 protein kinase C, iota [Homo sapiens] 313 2e-85
gi|5453974 protein kinase N2 [Homo sapiens] 313 2e-85
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 308 7e-84
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 308 7e-84
gi|13384594 protein kinase C, gamma [Homo sapiens] 305 7e-83
gi|5453976 protein kinase C, theta [Homo sapiens] 298 7e-81
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 298 9e-81
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 298 9e-81
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 298 9e-81
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 295 5e-80
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 295 5e-80
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 961 bits (2484), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
Query: 61 LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
Sbjct: 61 LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
Query: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
Sbjct: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
Query: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
Sbjct: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
Query: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
Sbjct: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
Query: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
Sbjct: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
Query: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
Sbjct: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
Query: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465
PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK
Sbjct: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 929 bits (2402), Expect = 0.0
Identities = 452/465 (97%), Positives = 456/465 (98%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ 60
Query: 61 LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
Sbjct: 61 LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS 120
Query: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
Sbjct: 121 PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK 180
Query: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
Sbjct: 181 KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE 240
Query: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
Sbjct: 241 RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA 300
Query: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
Sbjct: 301 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM 360
Query: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
Sbjct: 361 EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
Query: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDCGMLGNWKK 465
PFKPQVTSETDTRYFDEEFTAQTITITPPEK + + N ++
Sbjct: 421 PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERR 465
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 776 bits (2004), Expect = 0.0
Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 60 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
S DN G EEM+ S K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
ILME+I+FPRTL +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++ +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 776 bits (2004), Expect = 0.0
Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 60 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
S DN G EEM+ S K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
ILME+I+FPRTL +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++ +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 776 bits (2004), Expect = 0.0
Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59
MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 60 QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119
QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
Query: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178
S DN G EEM+ S K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238
LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
Query: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297
RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
Query: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357
D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
Query: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417
ILME+I+FPRTL +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
Query: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457
L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++ +C
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 744 bits (1922), Expect = 0.0
Identities = 358/456 (78%), Positives = 409/456 (89%), Gaps = 6/456 (1%)
Query: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQ--DVDLPYPLNNFSVAK 58
M++V+++KEGW+ KRGEYIK WRPRYFLLK+DGSFIGYKE+P+ D LP PLNNFSVA+
Sbjct: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLP-PLNNFSVAE 59
Query: 59 CQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQE--EER 116
CQLMKTERP+PNTF+IRCLQWTTVIERTFHVD+P+EREEW AIQ VA+ L+++ E+
Sbjct: 60 CQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDP 119
Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
M+ S D+ EEM+ + + + K TMNDFDYLKLLGKGTFGKVILVREKA+G+YYA
Sbjct: 120 MDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYA 179
Query: 176 MKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
MKIL+KEVIIAKDEVAHT+TESRVL+NTRHPFLT+LKY+FQT DRLCFVMEY NGGELFF
Sbjct: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
HLSRERVF+E+R RFYGAEIVSAL+YLHS +VYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
GI+D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
ELILME+I+FPRTLS +AKSLL+GLL KDP +RLGGGP DAKE+M H FF +NWQDV
Sbjct: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451
KKL+PPFKPQVTSE DTRYFD+EFTAQ+ITITPP++
Sbjct: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDR 455
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 348 bits (893), Expect = 6e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 54 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111
Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171
Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231
Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350
Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 394
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 348 bits (893), Expect = 6e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 68 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 125
Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 126 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 185
Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 186 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 245
Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 246 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 305
Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 306 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 364
Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 365 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 408
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 348 bits (893), Expect = 6e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 82 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139
Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199
Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259
Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378
Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 422
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 348 bits (893), Expect = 6e-96
Identities = 173/344 (50%), Positives = 231/344 (67%), Gaps = 4/344 (1%)
Query: 102 IQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGK 161
+Q++ Q QE E MN +P+ + + S+ H + + DF +LK++GKG+FGK
Sbjct: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206
Query: 162 VILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDR 220
V+L R KA +YA+K+L+K+ I+ K E H ++E VL KN +HPFL L +SFQT D+
Sbjct: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266
Query: 221 LCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD 280
L FV++Y+NGGELF+HL RER F E R RFY AEI SAL YLHS IVYRDLK EN++LD
Sbjct: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326
Query: 281 KDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 340
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
Query: 341 CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIM 400
G PFY+++ ++++ IL + ++ +++ A+ LL GLL KD KRL G DD EI
Sbjct: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445
Query: 401 RHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTI 444
H FFS +NW D+ +KK+ PPF P V+ D R+FD EFT + +
Sbjct: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 489
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 342 bits (877), Expect = 4e-94
Identities = 170/334 (50%), Positives = 222/334 (66%), Gaps = 5/334 (1%)
Query: 116 RMNCSPT---SQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
RMN SP S + ++ + + DFD+LK++GKG +GKV+L + K+ G
Sbjct: 60 RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119
Query: 173 YYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
+YA+K+L+K+ I+ K E +H + E VL KN RHPFL L+YSFQT ++L FV++YVNGG
Sbjct: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGG 179
Query: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
ELFFHL RER F E R RFY AE+ SA+ YLHS I+YRDLK EN++LD GH+ +TDFG
Sbjct: 180 ELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFG 239
Query: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 351
LCKEG+ T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD
Sbjct: 240 LCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDV 299
Query: 352 EKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQ 411
+++E IL + ++ P + A LL LL KD +RL G D EI H FFS +NW
Sbjct: 300 SQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWD 358
Query: 412 DVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 359 DLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 341 bits (875), Expect = 7e-94
Identities = 164/300 (54%), Positives = 211/300 (70%), Gaps = 2/300 (0%)
Query: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL-KNTRH 205
DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K+ I+ K E +H + E VL KN RH
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
PFL L+YSFQT ++L FV++YVNGGELFFHL RER F E R RFY AE+ SA+ YLHS
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
I+YRDLK EN++LD GH+ +TDFGLCKEG+ T TFCGTPEYLAPEVL Y R
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
AVDWW LG V+YEM+ G PFY+QD +++E IL + ++ P + A LL LL KD
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQ 273
Query: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
+RL G D EI H FFS +NW D+Y K+L PPF P VT D ++FD EFT + ++
Sbjct: 274 RQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 333 bits (855), Expect = 2e-91
Identities = 165/358 (46%), Positives = 236/358 (65%), Gaps = 4/358 (1%)
Query: 93 EEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLK 152
+E +E I+ R EE R SP Q+ + GE + KR +++F+++K
Sbjct: 354 QEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENG-EVRQGQAKRLGLDEFNFIK 412
Query: 153 LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSL 211
+LGKG+FGKV+L K + YA+K+LKK+VI+ D+V T+TE R+L R HP+LT L
Sbjct: 413 VLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQL 472
Query: 212 KYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRD 271
FQTKDRL FVMEYVNGG+L F + R R F E R+RFY AE+ SAL +LH ++YRD
Sbjct: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532
Query: 272 LKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 331
LKL+N++LD +GH K+ DFG+CKEGI + T TFCGTP+Y+APE+L++ +YG +VDWW
Sbjct: 533 LKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWA 592
Query: 332 LGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLG- 390
LGV+MYEMM G+ PF + + LFE IL +D+ +P LS +A S+L + K+P+KRLG
Sbjct: 593 LGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGC 652
Query: 391 -GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITIT 447
+ I +H FF ++W + KK+ PPFKP++ ++ D FD++FT + +T
Sbjct: 653 VASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLT 710
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 333 bits (855), Expect = 2e-91
Identities = 162/370 (43%), Positives = 237/370 (64%), Gaps = 14/370 (3%)
Query: 87 FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142
F+V P E E E ++ +R + + E + S+ DN G + R
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336
Query: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202
+ DF++L +LGKG+FGKV+L K + + YA+KILKK+V+I D+V T+ E RVL
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261
+ PFLT L FQT DRL FVMEYVNGG+L +H+ + F E FY AEI L +
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
L S I+YRDLKL+N+MLD +GHIKI DFG+CKE I D T KTFCGTP+Y+APE++
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ ++ +P+++S +A ++ GL+
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441
K P KRLG GP+ ++I H+FF ++W+ + K++ PP+KP+ + DT FD+EFT
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTR 636
Query: 442 QTITITPPEK 451
Q + +TP +K
Sbjct: 637 QPVELTPTDK 646
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 331 bits (849), Expect = 7e-91
Identities = 180/401 (44%), Positives = 240/401 (59%), Gaps = 26/401 (6%)
Query: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
Query: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
GI + T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY +D +++
Sbjct: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370
Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429
Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
KK+ PPF P V D R FD FT +T+ P C SD
Sbjct: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 467
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 331 bits (849), Expect = 7e-91
Identities = 180/401 (44%), Positives = 240/401 (59%), Gaps = 26/401 (6%)
Query: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
Query: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
Query: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
Query: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
Query: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
GI + T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY +D +++
Sbjct: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370
Query: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429
Query: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
KK+ PPF P V D R FD FT +T+ P C SD
Sbjct: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 467
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 323 bits (829), Expect = 2e-88
Identities = 155/343 (45%), Positives = 223/343 (65%), Gaps = 12/343 (3%)
Query: 118 NCSPTSQI----------DNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVRE 167
N SPTS++ +E R +++F+++++LGKG+FGKV+L R
Sbjct: 315 NISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARV 374
Query: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLKYSFQTKDRLCFVME 226
K +G YA+K+LKK+VI+ D+V T+TE R+L R HPFLT L FQT DRL FVME
Sbjct: 375 KETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVME 434
Query: 227 YVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIK 286
+VNGG+L FH+ + R F E R RFY AEI+SAL +LH I+YRDLKL+N++LD +GH K
Sbjct: 435 FVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCK 494
Query: 287 ITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 346
+ DFG+CKEGI + T TFCGTP+Y+APE+L++ YG AVDWW +GV++YEM+CG PF
Sbjct: 495 LADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF 554
Query: 347 YNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKE-IMRHSFF 405
++ + LFE IL +++ +P L DA +L + K+P RLG + I+RH FF
Sbjct: 555 EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 614
Query: 406 SGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITP 448
++W + +++ PPF+P++ S D FD +F + +TP
Sbjct: 615 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTP 657
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 320 bits (819), Expect = 2e-87
Identities = 158/370 (42%), Positives = 232/370 (62%), Gaps = 15/370 (4%)
Query: 87 FHVDTPEEREEWTEAIQAVADRLQRQE----EERMNCSPTSQIDNIGEEEMDASTTHHKR 142
F+V P E E E ++ +R + + E + S+ DN G + R
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRD---------R 336
Query: 143 KTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN 202
+ DF++L +LGKG+FGKV+L K + + YA+KILKK+V+I D+V T+ E RVL
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 203 T-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDY 261
+ PFLT L FQT DRL FVMEYVNGG+L +H+ + F E FY AEI L +
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
L S I+YRDLKL+N+MLD +GHIKI DFG+CKE I D T KTFCGTP+Y+APE++
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLL 381
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ ++ +P+++S +A ++ GL+
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 382 IKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441
K P KRLG GP+ ++I H+FF ++W+ + K++ PP+KP+ + FD FT
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635
Query: 442 QTITITPPEK 451
+TPP++
Sbjct: 636 HPPVLTPPDQ 645
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 316 bits (810), Expect = 2e-86
Identities = 156/366 (42%), Positives = 233/366 (63%), Gaps = 10/366 (2%)
Query: 87 FHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMN 146
++V PE EE + RQ+ E+ P E+ + + R +
Sbjct: 286 YNVPIPEGDEEGNMEL--------RQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
Query: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-RH 205
DF++L +LGKG+FGKV+L K + + YA+KILKK+V+I D+V T+ E RVL +
Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
Query: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
PFLT L FQT DRL FVMEYVNGG+L +H+ + F E + FY AEI L +LH
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
I+YRDLKL+N+MLD +GHIKI DFG+CKE + D T +TFCGTP+Y+APE++ YG+
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
Query: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
+VDWW GV++YEM+ G+ PF +D ++LF+ I+ ++ +P++LS +A S+ GL+ K P
Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
Query: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
KRLG GP+ +++ H+FF ++W+ + ++++ PPFKP+V + FD+ FT
Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPV 636
Query: 446 ITPPEK 451
+TPP++
Sbjct: 637 LTPPDQ 642
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 313 bits (803), Expect = 2e-85
Identities = 159/349 (45%), Positives = 223/349 (63%), Gaps = 17/349 (4%)
Query: 118 NCSPTSQIDNIGEEEMDASTTHHKRKT-----MNDFDYLKLLGKGTFGKVILVREKASGK 172
N S +D +GEE+ +A T K + DFD L+++G+G++ KV+LVR K + +
Sbjct: 220 NPSSHESLDQVGEEK-EAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDR 278
Query: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGG 231
YAMK++KKE++ +++ TE V + + HPFL L FQT+ RL FV+EYVNGG
Sbjct: 279 IYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGG 338
Query: 232 ELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFG 291
+L FH+ R+R E+ RFY AEI AL+YLH I+YRDLKL+N++LD +GHIK+TD+G
Sbjct: 339 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYG 398
Query: 292 LCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF----- 346
+CKEG+ T TFCGTP Y+APE+L DYG +VDWW LGV+M+EMM GR PF
Sbjct: 399 MCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGS 458
Query: 347 -YNQD---HEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDA-KEIMR 401
N D + LF++IL + I+ PR+LS A S+L L KDP +RLG P +I
Sbjct: 459 SDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQG 518
Query: 402 HSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE 450
H FF V+W + K++VPPFKP ++ E FD +FT + + +TP +
Sbjct: 519 HPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 313 bits (803), Expect = 2e-85
Identities = 154/347 (44%), Positives = 226/347 (65%), Gaps = 5/347 (1%)
Query: 109 LQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVRE 167
L + + E +P S ++ G +E++ + + + + DF +LG+G FGKV+L
Sbjct: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
Query: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK---NTRHPFLTSLKYSFQTKDRLCFV 224
K + + +A+K LKK I+A+DEV + E R+ + + RHPFL +L FQTK+ +CFV
Sbjct: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
Query: 225 MEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGH 284
MEY GG+L H+ + VFSE R FY A +V L YLH KIVYRDLKL+NL+LD +G
Sbjct: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF 795
Query: 285 IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344
+KI DFGLCKEG+ TFCGTPE+LAPEVL + Y RAVDWWGLGV++YEM+ G
Sbjct: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
Query: 345 PFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSF 404
PF D E++F+ I+ +++++PR LS++A S++ LL ++P +RLG DA+++ +H F
Sbjct: 856 PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 915
Query: 405 FSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451
F ++W + DKK+ PPF P + D FD+EFT++ +TPP +
Sbjct: 916 FRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE 962
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 308 bits (789), Expect = 7e-84
Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)
Query: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
T+ DF +L +LG+G FGKV+L + SG+ +A+K LKK I+A+DEV + E R+L
Sbjct: 617 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 676
Query: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
+ HPFL +L FQT + +CFVMEY GG+L H+ + VFSE R FY A +V L
Sbjct: 677 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 735
Query: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
+LH KIVYRDLKL+NL+LD +G++KI DFGLCKEG+ TFCGTPE+LAPEVL D
Sbjct: 736 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 795
Query: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +++++PR LS++A ++ L
Sbjct: 796 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 855
Query: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
L ++P +RLG DA+++ + FF + W+ + ++L PPF P ++ TD FDEEFT
Sbjct: 856 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 915
Query: 441 AQTITITPP 449
+ T++PP
Sbjct: 916 GEAPTLSPP 924
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 308 bits (789), Expect = 7e-84
Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)
Query: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
T+ DF +L +LG+G FGKV+L + SG+ +A+K LKK I+A+DEV + E R+L
Sbjct: 611 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 670
Query: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
+ HPFL +L FQT + +CFVMEY GG+L H+ + VFSE R FY A +V L
Sbjct: 671 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 729
Query: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
+LH KIVYRDLKL+NL+LD +G++KI DFGLCKEG+ TFCGTPE+LAPEVL D
Sbjct: 730 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 789
Query: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +++++PR LS++A ++ L
Sbjct: 790 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 849
Query: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
L ++P +RLG DA+++ + FF + W+ + ++L PPF P ++ TD FDEEFT
Sbjct: 850 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 909
Query: 441 AQTITITPP 449
+ T++PP
Sbjct: 910 GEAPTLSPP 918
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 305 bits (780), Expect = 7e-83
Identities = 146/316 (46%), Positives = 207/316 (65%), Gaps = 7/316 (2%)
Query: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK 201
R ++DF +L +LGKG+FGKV+L + S + YA+KILKK+VI+ D+V TL E RVL
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
Query: 202 ------NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
R FLT L +FQT DRL FVMEYV GG+L +H+ + F E FY AEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
Query: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
L +LH+ I+YRDLKL+N+MLD +GHIKITDFG+CKE + T +TFCGTP+Y+AP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
Query: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
E++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++LS +A +
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
Query: 376 LLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
+ G L K P KRLG GPD I H FF ++W+ + ++ PPF+P+ + F
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN-F 643
Query: 436 DEEFTAQTITITPPEK 451
D+ FT +TPP++
Sbjct: 644 DKFFTRAAPALTPPDR 659
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 298 bits (763), Expect = 7e-81
Identities = 150/325 (46%), Positives = 211/325 (64%), Gaps = 9/325 (2%)
Query: 120 SPTSQID---NIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
SP ++D ++ E E++ + K + DF K+LGKG+FGKV L K + +++A
Sbjct: 348 SPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407
Query: 176 MKILKKEVIIAKDEVAHTLTESRVLKNT-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234
+K LKK+V++ D+V T+ E RVL HPFLT + +FQTK+ L FVMEY+NGG+L
Sbjct: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467
Query: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294
+H+ F R FY AEI+ L +LHS IVYRDLKL+N++LDKDGHIKI DFG+CK
Sbjct: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527
Query: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354
E + A TFCGTP+Y+APE+L Y +VDWW GV++YEM+ G+ PF+ QD E+L
Sbjct: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
Query: 355 FELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVY 414
F I M++ +PR L +AK LL L +++P KRLG D I +H F +NW+++
Sbjct: 588 FHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELE 643
Query: 415 DKKLVPPFKPQVTSETDTRYFDEEF 439
K++ PPF+P+V S D FD+EF
Sbjct: 644 RKEIDPPFRPKVKSPFDCSNFDKEF 668
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 298 bits (762), Expect = 9e-81
Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)
Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
Query: 436 DEEFTAQTITITPPEK 451
D +FT++ + +TP ++
Sbjct: 366 DTQFTSEPVQLTPDDE 381
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 298 bits (762), Expect = 9e-81
Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)
Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
Query: 436 DEEFTAQTITITPPEK 451
D +FT++ + +TP ++
Sbjct: 366 DTQFTSEPVQLTPDDE 381
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 298 bits (762), Expect = 9e-81
Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)
Query: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
Query: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
Query: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
Query: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
Query: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
Query: 436 DEEFTAQTITITPPEK 451
D +FT++ + +TP ++
Sbjct: 549 DTQFTSEPVQLTPDDE 564
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 295 bits (756), Expect = 5e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 52 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 111
Query: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 112 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 170
Query: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 171 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230
Query: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 290
Query: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 291 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 350
Query: 426 VTSETDTRYFDEEFTAQTITITP 448
V DT YFD EFT++T +P
Sbjct: 351 VAQPDDTFYFDTEFTSRTPKDSP 373
Score = 119 bits (297), Expect = 8e-27
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 417 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 470
Query: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 471 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 530
Query: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 531 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 590
Query: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 591 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 650
Query: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
T+S AK L+S +L DP++RL AK++++H
Sbjct: 651 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 681
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 295 bits (756), Expect = 5e-80
Identities = 146/323 (45%), Positives = 212/323 (65%), Gaps = 9/323 (2%)
Query: 134 DASTTHH-----KRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVII 185
+ S THH ++ + F+ LK+LG+G+FGKV LVR+ SG YAMK+LKK +
Sbjct: 43 EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK 102
Query: 186 AKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSE 245
+D V T E +L + HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E
Sbjct: 103 VRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 161
Query: 246 DRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKT 305
+ +FY AE+ LD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +
Sbjct: 162 EDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 221
Query: 306 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKF 365
FCGT EY+APEV+ + + DWW GV+M+EM+ G LPF +D ++ LIL +
Sbjct: 222 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM 281
Query: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
P+ LS++A+SLL L ++P RLG GPD A+EI RH F+S ++W +Y +++ PPFKP
Sbjct: 282 PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPA 341
Query: 426 VTSETDTRYFDEEFTAQTITITP 448
V DT YFD EFT++T +P
Sbjct: 342 VAQPDDTFYFDTEFTSRTPKDSP 364
Score = 119 bits (297), Expect = 8e-27
Identities = 83/276 (30%), Positives = 140/276 (50%), Gaps = 23/276 (8%)
Query: 139 HHKRKTMNDFDYLK-LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTES 197
H K +D +K +G G++ + KA+ YA+K++ K +E+
Sbjct: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI------E 461
Query: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
+L+ +HP + +LK + + V E + GGEL + R++ FSE F I
Sbjct: 462 ILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGK 521
Query: 258 ALDYLHSGKIVYRDLKLENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYL 313
++YLHS +V+RDLK N++ +D+ G+ ++I DFG K+ + + T C T ++
Sbjct: 522 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 581
Query: 314 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------ 366
APEVL+ Y D W LG+++Y M+ G PF N + E++ + KF
Sbjct: 582 APEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 641
Query: 367 RTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRH 402
T+S AK L+S +L DP++RL AK++++H
Sbjct: 642 NTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQH 672
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,524,162
Number of Sequences: 37866
Number of extensions: 845625
Number of successful extensions: 4315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 2019
Number of HSP's gapped (non-prelim): 978
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.