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Search of human proteins with 32307150
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo
sapiens]
(1036 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 2105 0.0
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 2097 0.0
gi|83415184 transmembrane and tetratricopeptide repeat containin... 139 1e-32
gi|22749211 transmembrane and tetratricopeptide repeat containin... 116 1e-25
gi|118766328 transmembrane and tetratricopeptide repeat containi... 114 5e-25
gi|118766330 transmembrane and tetratricopeptide repeat containi... 114 5e-25
gi|224809432 transmembrane and tetratricopeptide repeat containi... 108 3e-23
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 103 6e-22
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 93 1e-18
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 93 1e-18
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 93 1e-18
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 79 2e-14
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 79 2e-14
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 79 2e-14
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 77 8e-14
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 77 8e-14
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 76 2e-13
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 72 3e-12
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 70 1e-11
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 69 2e-11
gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens] 69 2e-11
gi|34304360 nephrocystin 3 [Homo sapiens] 67 9e-11
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap... 65 4e-10
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap... 65 4e-10
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap... 65 4e-10
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap... 65 4e-10
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi... 65 4e-10
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 65 4e-10
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 65 4e-10
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 65 4e-10
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 2105 bits (5453), Expect = 0.0
Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)
Query: 1 MASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR 60
MASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR
Sbjct: 1 MASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRR 60
Query: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 120
LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
Sbjct: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 120
Query: 121 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF
Sbjct: 121 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
Query: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 240
AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR
Sbjct: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 240
Query: 241 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 300
ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA
Sbjct: 241 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 300
Query: 301 EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV 360
EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV
Sbjct: 301 EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV 360
Query: 361 LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD 420
LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD
Sbjct: 361 LQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD 420
Query: 421 AHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLV 480
AHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLV
Sbjct: 421 AHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLV 480
Query: 481 SIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLK 540
SIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLK
Sbjct: 481 SIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLK 540
Query: 541 LSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEAN 600
LSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEAN
Sbjct: 541 LSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEAN 600
Query: 601 HFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSG 660
HFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSG
Sbjct: 601 HFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSG 660
Query: 661 ALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIY 720
ALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIY
Sbjct: 661 ALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIY 720
Query: 721 DNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMI 780
DNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMI
Sbjct: 721 DNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMI 780
Query: 781 NRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQL 840
NRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQL
Sbjct: 781 NRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQL 840
Query: 841 YKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEE 900
YKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEE
Sbjct: 841 YKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEE 900
Query: 901 HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIA 960
HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIA
Sbjct: 901 HVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIA 960
Query: 961 KNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAG 1020
KNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAG
Sbjct: 961 KNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAG 1020
Query: 1021 NKPDHMIKPVEVTESA 1036
NKPDHMIKPVEVTESA
Sbjct: 1021 NKPDHMIKPVEVTESA 1036
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 2097 bits (5432), Expect = 0.0
Identities = 1036/1046 (99%), Positives = 1036/1046 (99%), Gaps = 10/1046 (0%)
Query: 1 MASSVGNVADST----------GLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLL 50
MASSVGNVADST GLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLL
Sbjct: 1 MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLL 60
Query: 51 LSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKP 110
LSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKP
Sbjct: 61 LSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKP 120
Query: 111 DFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACY 170
DFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACY
Sbjct: 121 DFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACY 180
Query: 171 LKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI 230
LKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI
Sbjct: 181 LKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI 240
Query: 231 FDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLA 290
FDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLA
Sbjct: 241 FDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLA 300
Query: 291 NALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEF 350
NALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEF
Sbjct: 301 NALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEF 360
Query: 351 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 410
AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR
Sbjct: 361 AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 420
Query: 411 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 470
AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT
Sbjct: 421 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWT 480
Query: 471 DYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHK 530
DYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHK
Sbjct: 481 DYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHK 540
Query: 531 PPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTN 590
PPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTN
Sbjct: 541 PPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTN 600
Query: 591 FRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQA 650
FRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQA
Sbjct: 601 FRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQA 660
Query: 651 MWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAV 710
MWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAV
Sbjct: 661 MWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAV 720
Query: 711 IDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN 770
IDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN
Sbjct: 721 IDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMN 780
Query: 771 TIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPED 830
TIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPED
Sbjct: 781 TIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPED 840
Query: 831 AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRI 890
AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRI
Sbjct: 841 AIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRI 900
Query: 891 IFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQL 950
IFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQL
Sbjct: 901 IFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQL 960
Query: 951 TCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLY 1010
TCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLY
Sbjct: 961 TCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLY 1020
Query: 1011 LQMWEHYAAGNKPDHMIKPVEVTESA 1036
LQMWEHYAAGNKPDHMIKPVEVTESA
Sbjct: 1021 LQMWEHYAAGNKPDHMIKPVEVTESA 1046
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 139 bits (350), Expect = 1e-32
Identities = 112/395 (28%), Positives = 179/395 (45%), Gaps = 9/395 (2%)
Query: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 120
L R + F + ++ P A+ + N N K++G+ +EAI HYR AL+L P NL
Sbjct: 358 LSRESLFRS-GVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG 416
Query: 121 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
D A Y ALQ +P +LGNLLK+ + EEA +I+ P F
Sbjct: 417 TL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 473
Query: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 240
A A+S+L + Q A ++ + P+ D + N G L + + ++AVA Y +
Sbjct: 474 ADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQ 533
Query: 241 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVA 300
A+ LSP+H V NL +Y G +A + Y+RA+++ H + L G
Sbjct: 534 AIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVA-HKAEILSPLGALYYNTGRYE 592
Query: 301 EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASV 360
EA Y A L P+ + LA + G +EA ++ + + L+++
Sbjct: 593 EALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAI 652
Query: 361 LQQQGKLQEALMHYKEAIRISP----TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINP 416
+Q +AL +A+++ P ++ + GN L+E + A + Y A+Q+NP
Sbjct: 653 YSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712
Query: 417 AFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
A A N+ I G A A Y AL+L PD
Sbjct: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747
Score = 122 bits (306), Expect = 2e-27
Identities = 104/378 (27%), Positives = 169/378 (44%), Gaps = 9/378 (2%)
Query: 57 QCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGY 116
Q R + H+ T A+K P A A +NLG + ++ EA +Y+ AL+L P
Sbjct: 388 QGRNKEAIYHYRT-ALKLYPRHASALNNLGTLTRDTA---EAKMYYQRALQLHPQHNRAL 443
Query: 117 INLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
NL L + E A+ +++Y P+ S L +LL R +EA+ Y I+
Sbjct: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
Query: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVA 236
P+ + +N G G A+ H+++A+ L P+ A +NLG + + A
Sbjct: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
Query: 237 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 296
Y RAL ++ + A + L +YY G + A+ Y+ A LQP + LA L
Sbjct: 564 WYKRALQVA-HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVM 622
Query: 297 GSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSN 356
G EAE N + + L+ I +Q N ++A+ KAL++ P+ S
Sbjct: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
Query: 357 L----ASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 412
L + L++Q L +A Y+ A++++P A A+ NMG A Y RA+
Sbjct: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
Query: 413 QINPAFADAHSNLASIHK 430
Q+ P NLA + +
Sbjct: 743 QLVPDSKLLKENLAKLDR 760
Score = 118 bits (296), Expect = 3e-26
Identities = 70/211 (33%), Positives = 115/211 (54%), Gaps = 3/211 (1%)
Query: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
+R ++ PH + N AN LK++G EA Y TAL+L P HA +LNNL + R+
Sbjct: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTA 423
Query: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
EA Y++AL++ P+ A NL ++L+ Q K +EA+ K++I+ P FADAYS++
Sbjct: 424 ---EAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
Query: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
+ L E + + A + Y I+ P +D H+N D+G +A+A Y+ A+KL P
Sbjct: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540
Query: 452 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSI 482
A NL + + + + +E K+ + +
Sbjct: 541 HHVAMVNLGRLYRSLGENSMAEEWYKRALQV 571
Score = 117 bits (292), Expect = 7e-26
Identities = 85/302 (28%), Positives = 144/302 (47%), Gaps = 5/302 (1%)
Query: 194 QGEIWLAIHH-FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH 252
Q EIWL+ F V P+ + N N LK+ A+ Y AL L P HA
Sbjct: 353 QNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASAL 412
Query: 253 GNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRL 312
NL + + + Y+RA++L P A NL N LK + EA +++
Sbjct: 413 NNLGTLTRDTAEAKMY---YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKY 469
Query: 313 CPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALM 372
P AD+ ++LA++ EQ +EA +Y+ ++ P+ + H+N L G ++A+
Sbjct: 470 GPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVA 529
Query: 373 HYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDS 432
HY++AI++SP+ A N+G + + + A + Y RA+Q+ A+ S L +++ ++
Sbjct: 530 HYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHK-AEILSPLGALYYNT 588
Query: 433 GNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRL 492
G EA+ Y+ A L+P + LA L ++ + ++ +VS LE RL
Sbjct: 589 GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRL 648
Query: 493 PS 494
S
Sbjct: 649 LS 650
Score = 91.3 bits (225), Expect = 4e-18
Identities = 78/289 (26%), Positives = 121/289 (41%), Gaps = 5/289 (1%)
Query: 51 LSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKP 110
L+S+ + R + IK P ++ ++N G + G ++A+ HY+ A++L P
Sbjct: 480 LASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSP 539
Query: 111 DFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACY 170
+NL + G+ A + Y ALQ + S LG L GR EEA Y
Sbjct: 540 SHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAE-ILSPLGALYYNTGRYEEALQIY 598
Query: 171 LKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI 230
+A QP+ L V G+ A V+ + L+ Y L + +
Sbjct: 599 QEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQEN 658
Query: 231 FDRAVAAYLRALSLSPNHAVVHGNLACV----YYEQGLIDLAIDTYRRAIELQPHFPDAY 286
D+A+ A +AL L P V L EQ L+D A ++YR A++L P A+
Sbjct: 659 HDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAW 718
Query: 287 CNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEE 335
N+ KG A Y AL+L P NLA + R + ++E
Sbjct: 719 MNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQE 767
Score = 51.2 bits (121), Expect = 5e-06
Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Query: 25 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP----LLAE 80
G + AE+ + +E LLS+I+ + D++ A++ P +++E
Sbjct: 623 GQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISE 682
Query: 81 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
+ GN +E+ L +A E YR A++L PD ++N+ G A Y AL
Sbjct: 683 LFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERAL 742
Query: 141 QYNPDLYCVRSDLGNLLKALGRLEEAK 167
Q PD ++ +L L + RL+E +
Sbjct: 743 QLVPDSKLLKENLAKLDRLEKRLQEVR 769
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 116 bits (291), Expect = 1e-25
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 16/339 (4%)
Query: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
GD + Y S ++ NP +LGN+LK+ ++ EA++ Y A+ + N A N
Sbjct: 475 GDWQNEEMLYRSGIKVNPAK--AWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYN 532
Query: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRAL---- 242
LG + A+H+++ A+ P AY+N G +L + A +L+
Sbjct: 533 LGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPD 592
Query: 243 -SLSPNHAVVHG------NLACVYYEQGLIDLAIDTYRRAIELQPH--FPDAYCNL-ANA 292
+L HA NL +Y+EQG + A+ Y+ AI+ P P + N+ A
Sbjct: 593 ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEA 652
Query: 293 LKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA 352
+ EAE Y +LR H + + G EA +L+ KA+E+ P
Sbjct: 653 YMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
Query: 353 AHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 412
+ + L ++ +L EA K+A + T D N + L++ + A + Y A
Sbjct: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
Query: 413 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
++ P + A NL +I +G + +A A+Y AL+LKPD
Sbjct: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811
Score = 107 bits (266), Expect = 8e-23
Identities = 93/335 (27%), Positives = 148/335 (44%), Gaps = 18/335 (5%)
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 131
IK NP A+A+ NLGNV K + ++ EA YR+AL + + D NL L
Sbjct: 488 IKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAE 545
Query: 132 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET-----------QPNF 180
A+ Y A+ P L + G +L GR EEA+ +LK E + +
Sbjct: 546 ALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSV 605
Query: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI----FDRAVA 236
NLG +++ QG A+ +++A+ P A +L N++ EA + A
Sbjct: 606 TSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQF-APQSLYNMMGEAYMRLSKLPEAEH 664
Query: 237 AYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK 296
Y+ +L +H H + G A + +AIEL P + Y + L E+
Sbjct: 665 WYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEE 724
Query: 297 GSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSN 356
+ EA + A L T D + N A++ R+ E A + Y A + P + AA N
Sbjct: 725 ARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMN 784
Query: 357 LASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
L ++L G+LQ+A +Y A+++ P SN+
Sbjct: 785 LGAILHLNGRLQKAEANYLRALQLKPDDVITQSNL 819
Score = 87.8 bits (216), Expect = 5e-17
Identities = 79/319 (24%), Positives = 125/319 (39%), Gaps = 16/319 (5%)
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
G + + Y I+ P A AW NLG V +Q +I A + A+ N D N
Sbjct: 475 GDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYN 532
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIEL-- 278
LG +L+E F A+ Y A+ P A + N + QG + A T+ + E+
Sbjct: 533 LGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPD 592
Query: 279 ----QPH-----FPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTH---ADSLNNLANI 326
PH NL E+G EA Y A++ P N +
Sbjct: 593 ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEA 652
Query: 327 KREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD 386
+ EA Y ++L + AH +L G+ EA + +AI + PT +
Sbjct: 653 YMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
Query: 387 AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTAL 446
Y + G L E + A + +A +++ D N A + + + A Y A
Sbjct: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
Query: 447 KLKPDFPDAYCNLAHCLQI 465
+L+P++P A NL L +
Sbjct: 773 RLRPNYPAALMNLGAILHL 791
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/339 (26%), Positives = 142/339 (41%), Gaps = 28/339 (8%)
Query: 14 LAELAHREYQAGDFEAAERHCMQLWRQEPD---NTGVLLLLSSIHFQCRRLDRSAHFSTL 70
L + + + + E+A R+ + D N G+LL +S R + H+ L
Sbjct: 499 LGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS------RFAEALHYYKL 552
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL-----------KPDFIDGYINL 119
AI P LA AY N G + +G+ +EA + + K NL
Sbjct: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612
Query: 120 AAALVAAGDMEGAVQAYVSALQYNPDLYCVRS---DLGNLLKALGRLEEAKACYLKAIET 176
G E A+ Y A+Q P + +S +G L +L EA+ Y++++ +
Sbjct: 613 GKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRS 672
Query: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN-VLKEARIFDRAV 235
+ + A G + G A F KA+ LDP + Y++ G +L+EAR+ + A
Sbjct: 673 KTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAE 732
Query: 236 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295
A +A L V N A + + L + A Y A L+P++P A NL L
Sbjct: 733 MAK-KAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHL 791
Query: 296 KGSVAEAEDCYNTALRLCPTHA---DSLNNLANIKREQG 331
G + +AE Y AL+L P +L L NI +QG
Sbjct: 792 NGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQG 830
Score = 73.6 bits (179), Expect = 9e-13
Identities = 71/256 (27%), Positives = 101/256 (39%), Gaps = 14/256 (5%)
Query: 247 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCY 306
N A GNL V Q I A YR A+ + + D NL L+E AEA Y
Sbjct: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550
Query: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA---AHS-------- 355
A+ PT A + N I QG EEA R + K E+ E AH
Sbjct: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY 610
Query: 356 NLASVLQQQGKLQEALMHYKEAIRISPT-FA--DAYSNMGNTLKEMQDVQGALQCYTRAI 412
NL + +QG +EAL YKEAI+ P FA Y+ MG + + A Y ++
Sbjct: 611 NLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL 670
Query: 413 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDY 472
+ AH + +G EA + A++L P + Y + L +
Sbjct: 671 RSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEA 730
Query: 473 DERMKKLVSIVADQLE 488
E KK + + + +
Sbjct: 731 AEMAKKAAELDSTEFD 746
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 114 bits (285), Expect = 5e-25
Identities = 70/213 (32%), Positives = 116/213 (54%), Gaps = 6/213 (2%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++ NP A +NLGN+ KER +LQEA E A++++PDF ++NL + E
Sbjct: 508 AVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 567
Query: 131 GAVQAYVSALQYN---PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNL 187
A Q+Y +A+++ PD Y +LG L L R +A + A +P ++AW+N+
Sbjct: 568 AAEQSYRTAIKHRRKYPDCY---YNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
Query: 188 GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPN 247
+ + G + A +A+ L PN +L NVL +++ + + A +L+A+ +PN
Sbjct: 625 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
Query: 248 HAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
A HGNLA +Y+ G +DLA Y +++L P
Sbjct: 685 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDP 717
Score = 112 bits (279), Expect = 2e-24
Identities = 77/287 (26%), Positives = 136/287 (47%)
Query: 116 YINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIE 175
+IN ++ +G+ Q + SAL P V ++G L G A Y +A+
Sbjct: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
Query: 176 TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAV 235
P + A +NLG + + E+ A AV + P+F A++NLG V + F+ A
Sbjct: 511 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 570
Query: 236 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295
+Y A+ + + NL +Y + A++ +R A L+P A+ N+ L
Sbjct: 571 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDN 630
Query: 296 KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 355
G++A+AE AL L P + +LAN+ + +E+ L+ KA++ P A+ H
Sbjct: 631 TGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHG 690
Query: 356 NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQ 402
NLA + + G L A HY+ ++++ PT + N G ++++ +Q
Sbjct: 691 NLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQ 737
Score = 107 bits (266), Expect = 8e-23
Identities = 72/264 (27%), Positives = 122/264 (46%)
Query: 93 GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSD 152
G+ + + +R AL + P + N+ L G+ A++ Y A++ NP ++
Sbjct: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
Query: 153 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDP 212
LGN+LK L+EA+ A++ QP+FA AW NLG V N+ A + A+
Sbjct: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
Query: 213 NFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTY 272
+ D Y NLG + + A+ A+ A L P H++ N+ + G + A
Sbjct: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
Query: 273 RRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGN 332
R A+EL P+ +LAN L + E+E + A++ P A NLA + G+
Sbjct: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
Query: 333 IEEAVRLYRKALEVFPEFAAAHSN 356
++ A + Y +L++ P + N
Sbjct: 702 LDLAKKHYEISLQLDPTASGTKEN 725
Score = 101 bits (251), Expect = 4e-21
Identities = 69/270 (25%), Positives = 123/270 (45%)
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
G + + A+ P A N+G +G AI ++ +AV L+P ++ A N
Sbjct: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
LGN+LKE A A+ + P+ A NL V + A +YR AI+ +
Sbjct: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 340
+PD Y NL + +A + + A L P H+ + NN+ + GN+ +A +
Sbjct: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
Query: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
R+ALE+ P + +LA+VL + K +E+ + +AI+ +P A + N+
Sbjct: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
Query: 401 VQGALQCYTRAIQINPAFADAHSNLASIHK 430
+ A + Y ++Q++P + N + +
Sbjct: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRR 731
Score = 94.7 bits (234), Expect = 4e-19
Identities = 67/252 (26%), Positives = 122/252 (48%), Gaps = 10/252 (3%)
Query: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
+R A+ + P + N+ L +KG+ A Y A+RL P + ++NNL NI +E+
Sbjct: 471 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 530
Query: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
++EA L A+++ P+FAAA NL V + + A Y+ AI+ + D Y N+
Sbjct: 531 ELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNL 590
Query: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
G ++ AL + A + P + A +N+ + ++GN+ +A A R AL+L P+
Sbjct: 591 GRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPN 650
Query: 452 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF-R 510
+LA+ L ++ K+ ++ ++ N P+ +H L L H +
Sbjct: 651 DHSLMFSLANVL-------GKSQKYKESEALFLKAIKAN--PNAASYHGNLAVLYHRWGH 701
Query: 511 KAIAERHGNLCL 522
+A++H + L
Sbjct: 702 LDLAKKHYEISL 713
Score = 91.7 bits (226), Expect = 3e-18
Identities = 50/174 (28%), Positives = 91/174 (52%)
Query: 286 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
+ N + G E + +AL +CP +A N+ ++GN A+R YR+A+
Sbjct: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
Query: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
+ P++ A +NL ++L+++ +LQEA A++I P FA A+ N+G ++ + A
Sbjct: 511 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 570
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
Q Y AI+ + D + NL ++ D +A+ ++R A LKP+ A+ N+
Sbjct: 571 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
Score = 91.3 bits (225), Expect = 4e-18
Identities = 67/266 (25%), Positives = 118/266 (44%), Gaps = 1/266 (0%)
Query: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 244
+ L CV + GE F A+++ P + N+G L + A+ Y A+ L
Sbjct: 453 NTLRCVLRS-GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL 511
Query: 245 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 304
+P + NL + E+ + A + A+++QP F A+ NL AE
Sbjct: 512 NPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQ 571
Query: 305 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 364
Y TA++ + D NL + + +A+ +R A + PE + A +N+ +L
Sbjct: 572 SYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNT 631
Query: 365 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 424
G L +A +EA+ + P ++ N L + Q + + + +AI+ NP A H N
Sbjct: 632 GNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGN 691
Query: 425 LASIHKDSGNIPEAIASYRTALKLKP 450
LA ++ G++ A Y +L+L P
Sbjct: 692 LAVLYHRWGHLDLAKKHYEISLQLDP 717
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/193 (25%), Positives = 91/193 (47%)
Query: 41 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100
+PD + L + +R + + AIK + Y NLG +Y + + +A+
Sbjct: 546 QPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALN 605
Query: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
+R+A LKP+ + N+ L G++ A AL+ P+ + + L N+L
Sbjct: 606 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 665
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
+ +E++A +LKAI+ PN A NL +++ G + LA H+E ++ LDP N
Sbjct: 666 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 725
Query: 221 LGNVLKEARIFDR 233
G + ++ + +
Sbjct: 726 YGLLRRKLELMQK 738
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/80 (30%), Positives = 37/80 (46%)
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQI 465
Q + A+ + P A H N+ D GN AI YR A++L P + A NL + L+
Sbjct: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Query: 466 VCDWTDYDERMKKLVSIVAD 485
+ + +E + V I D
Sbjct: 529 RNELQEAEELLSLAVQIQPD 548
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 114 bits (285), Expect = 5e-25
Identities = 70/213 (32%), Positives = 116/213 (54%), Gaps = 6/213 (2%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++ NP A +NLGN+ KER +LQEA E A++++PDF ++NL + E
Sbjct: 527 AVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 586
Query: 131 GAVQAYVSALQYN---PDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNL 187
A Q+Y +A+++ PD Y +LG L L R +A + A +P ++AW+N+
Sbjct: 587 AAEQSYRTAIKHRRKYPDCY---YNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 643
Query: 188 GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPN 247
+ + G + A +A+ L PN +L NVL +++ + + A +L+A+ +PN
Sbjct: 644 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 703
Query: 248 HAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
A HGNLA +Y+ G +DLA Y +++L P
Sbjct: 704 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDP 736
Score = 112 bits (279), Expect = 2e-24
Identities = 77/287 (26%), Positives = 136/287 (47%)
Query: 116 YINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIE 175
+IN ++ +G+ Q + SAL P V ++G L G A Y +A+
Sbjct: 470 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 529
Query: 176 TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAV 235
P + A +NLG + + E+ A AV + P+F A++NLG V + F+ A
Sbjct: 530 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 589
Query: 236 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295
+Y A+ + + NL +Y + A++ +R A L+P A+ N+ L
Sbjct: 590 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDN 649
Query: 296 KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 355
G++A+AE AL L P + +LAN+ + +E+ L+ KA++ P A+ H
Sbjct: 650 TGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHG 709
Query: 356 NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQ 402
NLA + + G L A HY+ ++++ PT + N G ++++ +Q
Sbjct: 710 NLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQ 756
Score = 107 bits (266), Expect = 8e-23
Identities = 72/264 (27%), Positives = 122/264 (46%)
Query: 93 GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSD 152
G+ + + +R AL + P + N+ L G+ A++ Y A++ NP ++
Sbjct: 481 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 540
Query: 153 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDP 212
LGN+LK L+EA+ A++ QP+FA AW NLG V N+ A + A+
Sbjct: 541 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 600
Query: 213 NFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTY 272
+ D Y NLG + + A+ A+ A L P H++ N+ + G + A
Sbjct: 601 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 660
Query: 273 RRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGN 332
R A+EL P+ +LAN L + E+E + A++ P A NLA + G+
Sbjct: 661 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 720
Query: 333 IEEAVRLYRKALEVFPEFAAAHSN 356
++ A + Y +L++ P + N
Sbjct: 721 LDLAKKHYEISLQLDPTASGTKEN 744
Score = 101 bits (251), Expect = 4e-21
Identities = 69/270 (25%), Positives = 123/270 (45%)
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
G + + A+ P A N+G +G AI ++ +AV L+P ++ A N
Sbjct: 481 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 540
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
LGN+LKE A A+ + P+ A NL V + A +YR AI+ +
Sbjct: 541 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 600
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 340
+PD Y NL + +A + + A L P H+ + NN+ + GN+ +A +
Sbjct: 601 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 660
Query: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
R+ALE+ P + +LA+VL + K +E+ + +AI+ +P A + N+
Sbjct: 661 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 720
Query: 401 VQGALQCYTRAIQINPAFADAHSNLASIHK 430
+ A + Y ++Q++P + N + +
Sbjct: 721 LDLAKKHYEISLQLDPTASGTKENYGLLRR 750
Score = 94.7 bits (234), Expect = 4e-19
Identities = 67/252 (26%), Positives = 122/252 (48%), Gaps = 10/252 (3%)
Query: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
+R A+ + P + N+ L +KG+ A Y A+RL P + ++NNL NI +E+
Sbjct: 490 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 549
Query: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
++EA L A+++ P+FAAA NL V + + A Y+ AI+ + D Y N+
Sbjct: 550 ELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNL 609
Query: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
G ++ AL + A + P + A +N+ + ++GN+ +A A R AL+L P+
Sbjct: 610 GRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPN 669
Query: 452 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF-R 510
+LA+ L ++ K+ ++ ++ N P+ +H L L H +
Sbjct: 670 DHSLMFSLANVL-------GKSQKYKESEALFLKAIKAN--PNAASYHGNLAVLYHRWGH 720
Query: 511 KAIAERHGNLCL 522
+A++H + L
Sbjct: 721 LDLAKKHYEISL 732
Score = 91.7 bits (226), Expect = 3e-18
Identities = 50/174 (28%), Positives = 91/174 (52%)
Query: 286 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
+ N + G E + +AL +CP +A N+ ++GN A+R YR+A+
Sbjct: 470 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 529
Query: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
+ P++ A +NL ++L+++ +LQEA A++I P FA A+ N+G ++ + A
Sbjct: 530 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 589
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
Q Y AI+ + D + NL ++ D +A+ ++R A LKP+ A+ N+
Sbjct: 590 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 643
Score = 91.3 bits (225), Expect = 4e-18
Identities = 67/266 (25%), Positives = 118/266 (44%), Gaps = 1/266 (0%)
Query: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 244
+ L CV + GE F A+++ P + N+G L + A+ Y A+ L
Sbjct: 472 NTLRCVLRS-GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL 530
Query: 245 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 304
+P + NL + E+ + A + A+++QP F A+ NL AE
Sbjct: 531 NPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQ 590
Query: 305 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 364
Y TA++ + D NL + + +A+ +R A + PE + A +N+ +L
Sbjct: 591 SYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNT 650
Query: 365 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 424
G L +A +EA+ + P ++ N L + Q + + + +AI+ NP A H N
Sbjct: 651 GNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGN 710
Query: 425 LASIHKDSGNIPEAIASYRTALKLKP 450
LA ++ G++ A Y +L+L P
Sbjct: 711 LAVLYHRWGHLDLAKKHYEISLQLDP 736
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/193 (25%), Positives = 91/193 (47%)
Query: 41 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100
+PD + L + +R + + AIK + Y NLG +Y + + +A+
Sbjct: 565 QPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALN 624
Query: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
+R+A LKP+ + N+ L G++ A AL+ P+ + + L N+L
Sbjct: 625 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 684
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
+ +E++A +LKAI+ PN A NL +++ G + LA H+E ++ LDP N
Sbjct: 685 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 744
Query: 221 LGNVLKEARIFDR 233
G + ++ + +
Sbjct: 745 YGLLRRKLELMQK 757
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/80 (30%), Positives = 37/80 (46%)
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQI 465
Q + A+ + P A H N+ D GN AI YR A++L P + A NL + L+
Sbjct: 488 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 547
Query: 466 VCDWTDYDERMKKLVSIVAD 485
+ + +E + V I D
Sbjct: 548 RNELQEAEELLSLAVQIQPD 567
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 108 bits (269), Expect = 3e-23
Identities = 93/385 (24%), Positives = 172/385 (44%), Gaps = 25/385 (6%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A+K N A+ ++N+G+ + + A++++ A ++PD I ++N+ +
Sbjct: 438 ALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTK 497
Query: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190
A ++Y+ A P + + A PN + NL +
Sbjct: 498 EAEESYMMAKSLMPQIIPGKK--------------------YAARIAPNHLNVYINLANL 537
Query: 191 FNA-QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHA 249
A + + A + +A+++ P+F AYI+ G +L + +A AYL+AL L N+A
Sbjct: 538 IRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNA 597
Query: 250 VVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV---AEAEDCY 306
+ NLA V+ E + A+ + RA+EL P A N A ++E G V EA
Sbjct: 598 DLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRL 657
Query: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGK 366
+ + P A+ NL + + EA +KA+++ +F +A NLA + Q K
Sbjct: 658 LSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAK 717
Query: 367 LQEALMHYKEAIRISPTFADAYSNMGNTL-KEMQDVQGALQCYTRAIQINPAFADAHSNL 425
+AL +E +R P G+ L + +D+ GA +C+ R ++++P+ NL
Sbjct: 718 ELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777
Query: 426 ASIHKDSGNIPEAIASYRTALKLKP 450
++ + ++ +A L L P
Sbjct: 778 CVVYFEEKDLLKAERCLLETLALAP 802
Score = 102 bits (254), Expect = 2e-21
Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 18/306 (5%)
Query: 164 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 223
E ++ A++ N A W+N+G + A+ +F +A + P+ + A++N+G
Sbjct: 429 ESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGR 488
Query: 224 VLKEARIFDRAVAAYLRALSL--------------SPNHAVVHGNLA-CVYYEQGLIDLA 268
K A +Y+ A SL +PNH V+ NLA + + ++ A
Sbjct: 489 TYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEA 548
Query: 269 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR 328
YR+AI ++P F AY + L + +A++ Y AL L +AD NLA +
Sbjct: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHI 608
Query: 329 EQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ---EALMHYKEAIRISPTFA 385
E EA++ + +ALE+ P+ A N A V+Q+ G+++ EA I P A
Sbjct: 609 ELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDA 668
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+ Y N+G + + A +AI++ F A NLA ++ + +A+
Sbjct: 669 NGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEEL 728
Query: 446 LKLKPD 451
L+ PD
Sbjct: 729 LRYYPD 734
Score = 89.4 bits (220), Expect = 2e-17
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 19/343 (5%)
Query: 59 RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHY--------------RH 104
+ +R+ + A P A+ N+G YK + +EA E Y ++
Sbjct: 460 KNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKY 519
Query: 105 ALRLKPDFIDGYINLAAALVA-AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRL 163
A R+ P+ ++ YINLA + A +E A Q Y A+ PD G LL + +
Sbjct: 520 AARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKP 579
Query: 164 EEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN 223
+AK YLKA+E N A W NL V E A+ +F +A+ L+P A N
Sbjct: 580 LKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAI 639
Query: 224 VLKEA---RIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
V++E+ ++ A L ++ P A + NL + + + A ++AI+LQ
Sbjct: 640 VMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQA 699
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANI-KREQGNIEEAVRL 339
F A NLA + +A LR P H L +I ++ +I A +
Sbjct: 700 DFRSALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKC 759
Query: 340 YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382
+ + LE+ P NL V ++ L +A E + ++P
Sbjct: 760 FERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
Score = 88.2 bits (217), Expect = 4e-17
Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 24/286 (8%)
Query: 204 FEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQG 263
F A+ ++ N + N+G+ L+ + F+RA+ +L+A + P+ H N+ Y
Sbjct: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
Query: 264 LIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNL 323
A ++Y A L P A R+ P H + NL
Sbjct: 495 RTKEAEESYMMAKSLMPQIIPGK--------------------KYAARIAPNHLNVYINL 534
Query: 324 AN-IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382
AN I+ + +EEA +LYR+A+ + P+F A+ + +L + K +A Y +A+ +
Sbjct: 535 ANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDR 594
Query: 383 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI---PEAI 439
AD + N+ E+++ AL+ + RA+++NP A N A + ++SG + PEA
Sbjct: 595 NNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEAR 654
Query: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 485
+ + +P + Y NL + + MKK + + AD
Sbjct: 655 KRLLSYINEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQAD 700
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 103 bits (258), Expect = 6e-22
Identities = 110/431 (25%), Positives = 173/431 (40%), Gaps = 87/431 (20%)
Query: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID----GYI--NLAAALVAAGDMEGA 132
A A SNLGN + RG+ +A +Y LRL PD D G + NL A G+ + A
Sbjct: 594 ARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEA 653
Query: 133 VQAYVSALQYNPDL---------YCVRSDLGNLLKALGRLEEAKAC--YLKAI-----ET 176
V+ Y L DL YC +LG KAL +A+ C YL ++ +
Sbjct: 654 VKYYEQDLALAKDLHDKLSQAKAYC---NLGLAFKALLNFSKAEECQKYLLSLAQSLNNS 710
Query: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLD------AYINLGNVLKEARI 230
Q F A NLG +F + +I AI +E+ + L D AY LG + +
Sbjct: 711 QAKFR-ALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQK 769
Query: 231 FDRAVAAYLRALSL------SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
+D+A+ + + L + P HG+LA VY G +A Y ++L D
Sbjct: 770 YDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKD 829
Query: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344
A N+ K +EEA+ + + L
Sbjct: 830 P----------------------------SLEAQVYGNMGITKMNMNVMEEAIGYFEQQL 861
Query: 345 EVFPEFAA---------AHSNLASVLQQQGKLQEALMHYKEAIRISPTF------ADAYS 389
+ + + A+ NL + G +EA+ +Y++ + ++ + A AY
Sbjct: 862 AMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYR 921
Query: 390 NMGNTLKEMQDVQGALQCYTR----AIQINPAF--ADAHSNLASIHKDSGNIPEAIASYR 443
+GN + M +Q AL C+ + A ++ AF A A+ L S+H GN +AI+
Sbjct: 922 GLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLE 981
Query: 444 TALKLKPDFPD 454
L + D D
Sbjct: 982 RQLNIARDMKD 992
Score = 95.9 bits (237), Expect = 2e-19
Identities = 113/469 (24%), Positives = 188/469 (40%), Gaps = 108/469 (23%)
Query: 81 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
A+ NLG+ + +G +EA+ ++RH L L D ++AL + G + A+ Y +AL
Sbjct: 276 AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLGHVYTAIGDYPNAL 334
Query: 141 QYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVA--WSNLGCVFNAQGEIW 198
+ K C L A +++ + A N+G V+ A G+
Sbjct: 335 ASH-----------------------KQCVLLAKQSKDELSEARELGNMGAVYIAMGD-- 369
Query: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACV 258
FE AV L +LGN +EAR + +AY + +
Sbjct: 370 -----FENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD----------KAM 414
Query: 259 YYEQGLIDLAIDTYRRAIELQPH------------------FPDAYCNLANALKEK---- 296
Y +++LA + +AIE++ + + + +A LK++
Sbjct: 415 SYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEG 474
Query: 297 ------GSVAEAEDCYNTALRLCPTH---ADSLNNLANIKREQGNI----------EEAV 337
G + + + Y+TAL+L TH A L++ A R GN+ ++AV
Sbjct: 475 RASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAV 534
Query: 338 RLYRKALEVFPEF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD----- 386
+ +R+ L++ E A+ H NLA Q G AL HY+ + I+ D
Sbjct: 535 KYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEA 594
Query: 387 -AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS------NLASIHKDSGNIPEAI 439
A SN+GN + A Y + +++ P D NL H GN EA+
Sbjct: 595 RALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAV 654
Query: 440 ASYRTALKLKPDFPD------AYCNLAHCLQIVCDWTDYDERMKKLVSI 482
Y L L D D AYCNL + + +++ +E K L+S+
Sbjct: 655 KYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSL 703
Score = 87.0 bits (214), Expect = 8e-17
Identities = 111/486 (22%), Positives = 186/486 (38%), Gaps = 71/486 (14%)
Query: 9 ADSTGLAELAHREYQAGDFE---AAERHCMQLWRQEPDNTGV---LLLLSSIHFQCRRLD 62
A S+ L+ L H GD+ A+ + C+ L +Q D L + +++ +
Sbjct: 312 AASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFE 371
Query: 63 RSAHFSTLAIKQNPLL------AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGY 116
+ +K L A AYSNLG+ Y R +A+ ++ + L L + ++
Sbjct: 372 NAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKA 431
Query: 117 INLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
I + A G +Q A QY+ + DL + R E +A
Sbjct: 432 IEM-RAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKD------RAAEGRAS------- 477
Query: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLD------AYINLGNVLKEARI 230
SNLG + +G+ A+ + + + D AY N+GN +
Sbjct: 478 --------SNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGM 529
Query: 231 FDRAVAAYLRALSLS------PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
+D+AV + + L +S + A HGNLA Y G D A+ Y+ + + D
Sbjct: 530 YDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589
Query: 285 ------AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS------LNNLANIKREQGN 332
A NL N +G +A Y LRL P D +NL GN
Sbjct: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGN 649
Query: 333 IEEAVRLYRKALEVFPEF------AAAHSNLASVLQ------QQGKLQEALMHYKEAIRI 380
+EAV+ Y + L + + A A+ NL + + + Q+ L+ +++
Sbjct: 650 YQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNN 709
Query: 381 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 440
S A N+G+ +D+ GA++ Y + + + D AS + G I
Sbjct: 710 SQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLE-ASAYAALGTAYRMIQ 768
Query: 441 SYRTAL 446
Y AL
Sbjct: 769 KYDKAL 774
Score = 68.2 bits (165), Expect = 4e-11
Identities = 99/486 (20%), Positives = 182/486 (37%), Gaps = 63/486 (12%)
Query: 6 GNVADSTGLAELAHREYQA---GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLD 62
G V E + QA GDF A + +P N + S+ + + ++ D
Sbjct: 50 GPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYD 109
Query: 63 RSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAA 122
++ + A NP +AY G + G+ +A+ + L P + + + A
Sbjct: 110 KALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEA 169
Query: 123 LVAAGDMEGAVQAY--VSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
+ + + Y + ++ + + V S +G L G + +E
Sbjct: 170 AMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGH----HGASVVVLEAALKI 225
Query: 181 AVAWSNL-GCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYL 239
L G VF+A + ++ + EK+ LD LG+ E R
Sbjct: 226 GTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECR---------- 275
Query: 240 RALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSV 299
HGNL ++ +G A+ +R + L D ++AL G V
Sbjct: 276 -----------AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREA-ASSALSSLGHV 323
Query: 300 AEAEDCYNTAL---RLCP----------THADSLNNLANIKREQGNIEEAVRLYRKALEV 346
A Y AL + C + A L N+ + G+ E AV+ + + L++
Sbjct: 324 YTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKI 383
Query: 347 FP------EFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD------AYSNMGNT 394
E A A+SNL S + +A+ ++ + ++ + AY+ +G+
Sbjct: 384 AKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHA 443
Query: 395 LKEMQDVQGALQCYTRAIQINPAFAD------AHSNLASIHKDSGNIPEAIASYRTALKL 448
+ MQD++ A Q + + + I D A SNL IH+ G+ A+ ++T L +
Sbjct: 444 ARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCI 503
Query: 449 KPDFPD 454
+ D
Sbjct: 504 AQELSD 509
Score = 58.2 bits (139), Expect = 4e-08
Identities = 91/441 (20%), Positives = 166/441 (37%), Gaps = 54/441 (12%)
Query: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
GD A+ Y AL +P + S+ + + ++A +KA P + A+
Sbjct: 72 GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFR 131
Query: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY--LRALSL 244
G G A+ F + DP L + + ++ + D Y L+ + L
Sbjct: 132 QGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKL 191
Query: 245 SPNHAVV-------------HGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLAN 291
+ VV HG A V + + + + + + AY +L N
Sbjct: 192 DKSPFVVVSVVGQELLTAGHHG--ASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGN 249
Query: 292 ALKEKGSVAEAEDCYNT---ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 348
K G + + D T C H NL + +GN EA+ +R L +
Sbjct: 250 TEKSTGYMQQDLDVAKTLGDQTGECRAH----GNLGSAFFSKGNYREALTNHRHQLVLAM 305
Query: 349 EF------AAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS------NMGNTLK 396
+ ++A S+L V G AL +K+ + ++ D S NMG
Sbjct: 306 KLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYI 365
Query: 397 EMQDVQGALQCYTRAIQINPAF------ADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
M D + A+QC+ + ++I A A+SNL S + N +A++ + L+L
Sbjct: 366 AMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
Query: 451 DFPD------AYCNLAH---CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSM 501
+ + AY L H C+Q + Y E+ + + D+ + R S + +
Sbjct: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASS---NLGI 482
Query: 502 LYPLSHGFRKAIAERHGNLCL 522
++ + + A+ +LC+
Sbjct: 483 IHQMKGDYDTALKLHKTHLCI 503
Score = 49.3 bits (116), Expect = 2e-05
Identities = 57/237 (24%), Positives = 95/237 (40%), Gaps = 32/237 (13%)
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL------KPDFID---GYINLAAA 122
+K L A+ Y N+G ++EAI ++ L + +D Y NL
Sbjct: 827 LKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDC 886
Query: 123 LVAAGDMEGAVQAYVSALQYNPDLYCVRSD------LGNLLKALGRLEEAKACYLKAIET 176
A GD E A++ Y L L ++ LGN +A+G L++A C+ K +
Sbjct: 887 YEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVV 946
Query: 177 QP------NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF------LDAYINLGNV 224
N A A+ LG + + G AI E+ + + + DA LG V
Sbjct: 947 AHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGV 1006
Query: 225 LKEARIFDRAVAAYLRALSLS--PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
++ +D A+ + L ++ N+ G Y GL ++ T+ RA+ Q
Sbjct: 1007 YQQMGEYDTALQYHQLDLQIAEETNNPTCQGR---AYGNLGLTYESLGTFERAVVYQ 1060
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/230 (25%), Positives = 91/230 (39%), Gaps = 50/230 (21%)
Query: 81 AYSNLGNVYKERGQLQEAIEHYRH------ALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134
AY NLG+ Y+ G +EAI++Y +L D Y L A G ++ A+
Sbjct: 879 AYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALV 938
Query: 135 AYVSALQYNPDL------YCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAV------ 182
+ L +L +LG+L LG E+A +C +E Q N A
Sbjct: 939 CFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISC----LERQLNIARDMKDRA 994
Query: 183 ----AWSNLGCVFNAQGEIWLAI--HHFEKAVTLDPNFLD----AYINLGNVLKEARIFD 232
A LG V+ GE A+ H + + + N AY NLG + F+
Sbjct: 995 LESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFE 1054
Query: 233 RAVAAYLRALSLS------------------PNHAVVHGNLACVYYEQGL 264
RAV + LS++ +HA+ + + A +Y ++GL
Sbjct: 1055 RAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGL 1104
Score = 32.0 bits (71), Expect = 3.1
Identities = 37/139 (26%), Positives = 53/139 (38%), Gaps = 26/139 (18%)
Query: 51 LSSIHFQCRRLDRSAHFSTLAIK-----QNPLL-AEAYSNLGNVYKERGQLQEAIEHYRH 104
L ++ Q D + + L ++ NP AY NLG Y+ G + A+ +
Sbjct: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
Query: 105 ALRLKPDFIDGYINLAAALV---AAGDMEGAVQAYVSALQY-------------NPDLYC 148
L + D LAA V + G A+Q Y A+ Y D
Sbjct: 1063 HLSIAAQMND----LAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAK 1118
Query: 149 VRSDLGNLLKALGRLEEAK 167
+R LG L A G LEEA+
Sbjct: 1119 IRHGLGLSLWASGNLEEAQ 1137
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 93.2 bits (230), Expect = 1e-18
Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%)
Query: 55 HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 111
H + + + +F T A+K NP +AY GN Y E G ++A + + AL + P
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
Query: 112 FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 164
+I I+ L A G + A + A+ +P Y V +GN A+ +
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224
A I T F +N G + G A+ ++ A+TL+P + AY N GN+
Sbjct: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485
Query: 225 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
R F +A + +AL P + V N A + A + + IE P +
Sbjct: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545
Query: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344
Y N A+ AE+ N AL L P A N A ++ + G IEEA+ Y +AL
Sbjct: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605
Query: 345 EV 346
++
Sbjct: 1606 DL 1607
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%)
Query: 186 NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 241
NLG + +G + LAI A+++D N A+ N + R A+ Y
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIV 1259
Query: 242 LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 297
L L V N +Y E G A++ +++A L + C+ +
Sbjct: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318
Query: 298 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 354
EA + + AL++ P D+ N E G+ E +A + + KAL + P + A
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 407
+ LQ QGK Q+A H+ AI P AY MGN MQD+ A++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
Query: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 458
T A + +N IH+ G+ A+ Y+ A+ L P + AY N
Sbjct: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481
Score = 74.7 bits (182), Expect = 4e-13
Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 9/286 (3%)
Query: 173 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 229
AI N +A+ N + E+ +A+ + + LD L+ ++N G + E
Sbjct: 1225 AISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
Query: 230 IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288
+ A+ + +A +S N ++ H C ++ + A++ + A+++ P F DAY
Sbjct: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 289 LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
N+ E G + +A+ + AL + P + + + + QG ++A + A++
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403
Query: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
P+ A+ A V Q G A+ A++IS T A+ +N G + M Q A+
Sbjct: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
+ Y AI +NP ++ A+ N +I+ +A + ALK P+
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508
Score = 67.8 bits (164), Expect = 5e-11
Identities = 94/442 (21%), Positives = 175/442 (39%), Gaps = 60/442 (13%)
Query: 59 RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQE----AIEHYRHALRLKPDFID 114
+ LD S+H S + A+ NLG Y E G LQ AI A+ + +
Sbjct: 1176 KALDASSH-SDKGPDATTISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYI 1234
Query: 115 GYINLAAALVAAGDMEGAVQAY--------VSALQYNPDLY--CVRSDLGNLLKALGRLE 164
+ N A +++ A+ Y ++ N L + +LG AL +
Sbjct: 1235 AFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFK 1294
Query: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224
+A A+ ++ N ++ + C + E A++ F A+ ++P FLDAY+ GN
Sbjct: 1295 QA------ALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNS 1347
Query: 225 LKEA---RIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH 281
E +A +L+AL ++P + + QG A + + AI+ P
Sbjct: 1348 YMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPK 1407
Query: 282 FPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYR 341
AY A + G+ A N A+++ T A+ L N I G+ + A++ Y+
Sbjct: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQ 1466
Query: 342 KALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT------------------ 383
A+ + P+++ A+ N ++ + +A ++ +A++ P
Sbjct: 1467 DAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKY 1526
Query: 384 ----------------FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLAS 427
+A Y N + ++ + A + +A+ + P A ++ A
Sbjct: 1527 EEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAK 1586
Query: 428 IHKDSGNIPEAIASYRTALKLK 449
+ G I EA+A Y AL L+
Sbjct: 1587 VRGKIGLIEEAMADYNQALDLE 1608
Score = 57.0 bits (136), Expect = 9e-08
Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%)
Query: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 138
A AY G +Y++ G+LQ A+ + + L+P F++ Y + + + A+
Sbjct: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
Query: 139 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 198
+YN + + + + A Y +AI++ P A + G ++ ++
Sbjct: 977 IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035
Query: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 256
LAI F K + DP DA + G E + A+ + L++ ++ G L
Sbjct: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095
Query: 257 CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 288
YY +Q LI + + +AIE+ C
Sbjct: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155
Query: 289 LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 337
L ++ K EA + AL AD L NL E+GN++
Sbjct: 1156 LLAKVQMKAKRTKEAVEVLKKALDASSHSDKGPDATTISADCLYNLGLCYMEEGNLQMTY 1215
Query: 338 RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 390
+L A+ + A N A + +LQ AL Y + + T + + N
Sbjct: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 391 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
G E+ AL+ + +A I+ A H EA+ + ALK+ P
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
Query: 451 DFPDAY 456
F DAY
Sbjct: 1336 CFLDAY 1341
Score = 36.2 bits (82), Expect = 0.16
Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385
I R+ G ++ A+ ++ + + P F A+ + + Q K+ EAL + +
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+AY + + +D+ A+ YT+AI+ P AD + +++ + + AI +
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044
Query: 446 LKLKPDFPDA-------YCNLAHCLQIVCDWT 470
+ P DA YC + + D+T
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 93.2 bits (230), Expect = 1e-18
Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%)
Query: 55 HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 111
H + + + +F T A+K NP +AY GN Y E G ++A + + AL + P
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
Query: 112 FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 164
+I I+ L A G + A + A+ +P Y V +GN A+ +
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224
A I T F +N G + G A+ ++ A+TL+P + AY N GN+
Sbjct: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485
Query: 225 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
R F +A + +AL P + V N A + A + + IE P +
Sbjct: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545
Query: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344
Y N A+ AE+ N AL L P A N A ++ + G IEEA+ Y +AL
Sbjct: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605
Query: 345 EV 346
++
Sbjct: 1606 DL 1607
Score = 76.6 bits (187), Expect = 1e-13
Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%)
Query: 186 NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 241
NLG + +G + LAI A+++D N A+ N + R A+ Y
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIV 1259
Query: 242 LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 297
L L V N +Y E G A++ +++A L + C+ +
Sbjct: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318
Query: 298 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 354
EA + + AL++ P D+ N E G+ E +A + + KAL + P + A
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 407
+ LQ QGK Q+A H+ AI P AY MGN MQD+ A++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
Query: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 458
T A + +N IH+ G+ A+ Y+ A+ L P + AY N
Sbjct: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481
Score = 74.7 bits (182), Expect = 4e-13
Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 9/286 (3%)
Query: 173 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 229
AI N +A+ N + E+ +A+ + + LD L+ ++N G + E
Sbjct: 1225 AISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
Query: 230 IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288
+ A+ + +A +S N ++ H C ++ + A++ + A+++ P F DAY
Sbjct: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 289 LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
N+ E G + +A+ + AL + P + + + + QG ++A + A++
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403
Query: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
P+ A+ A V Q G A+ A++IS T A+ +N G + M Q A+
Sbjct: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
+ Y AI +NP ++ A+ N +I+ +A + ALK P+
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508
Score = 65.5 bits (158), Expect = 3e-10
Identities = 89/422 (21%), Positives = 167/422 (39%), Gaps = 59/422 (13%)
Query: 79 AEAYSNLGNVYKERGQLQE----AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134
A+ NLG Y E G LQ AI A+ + + + N A +++ A+
Sbjct: 1195 ADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALT 1254
Query: 135 AY--------VSALQYNPDLY--CVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAW 184
Y ++ N L + +LG AL ++A A+ ++ N ++
Sbjct: 1255 DYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQA------ALISRTNGSLCH 1308
Query: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEA---RIFDRAVAAYLRA 241
+ C + E A++ F A+ ++P FLDAY+ GN E +A +L+A
Sbjct: 1309 ATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKA 1367
Query: 242 LSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAE 301
L ++P + + QG A + + AI+ P AY A + G+
Sbjct: 1368 LHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFA 1427
Query: 302 AEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL 361
A N A+++ T A+ L N I G+ + A++ Y+ A+ + P+++ A+ N ++
Sbjct: 1428 AMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIY 1486
Query: 362 QQQGKLQEALMHYKEAIRISPT----------------------------------FADA 387
+ +A ++ +A++ P +A
Sbjct: 1487 FHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAV 1546
Query: 388 YSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALK 447
Y N + ++ + A + +A+ + P A ++ A + G I EA+A Y AL
Sbjct: 1547 YFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD 1606
Query: 448 LK 449
L+
Sbjct: 1607 LE 1608
Score = 57.0 bits (136), Expect = 9e-08
Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%)
Query: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 138
A AY G +Y++ G+LQ A+ + + L+P F++ Y + + + A+
Sbjct: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
Query: 139 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 198
+YN + + + + A Y +AI++ P A + G ++ ++
Sbjct: 977 IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035
Query: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 256
LAI F K + DP DA + G E + A+ + L++ ++ G L
Sbjct: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095
Query: 257 CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 288
YY +Q LI + + +AIE+ C
Sbjct: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155
Query: 289 LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 337
L ++ K EA + AL AD L NL E+GN++
Sbjct: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
Query: 338 RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 390
+L A+ + A N A + +LQ AL Y + + T + + N
Sbjct: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 391 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
G E+ AL+ + +A I+ A H EA+ + ALK+ P
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
Query: 451 DFPDAY 456
F DAY
Sbjct: 1336 CFLDAY 1341
Score = 36.2 bits (82), Expect = 0.16
Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385
I R+ G ++ A+ ++ + + P F A+ + + Q K+ EAL + +
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+AY + + +D+ A+ YT+AI+ P AD + +++ + + AI +
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044
Query: 446 LKLKPDFPDA-------YCNLAHCLQIVCDWT 470
+ P DA YC + + D+T
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 93.2 bits (230), Expect = 1e-18
Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%)
Query: 55 HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 111
H + + + +F T A+K NP +AY GN Y E G ++A + + AL + P
Sbjct: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
Query: 112 FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 164
+I I+ L A G + A + A+ +P Y V +GN A+ +
Sbjct: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
Query: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224
A I T F +N G + G A+ ++ A+TL+P + AY N GN+
Sbjct: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485
Query: 225 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284
R F +A + +AL P + V N A + A + + IE P +
Sbjct: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545
Query: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344
Y N A+ AE+ N AL L P A N A ++ + G IEEA+ Y +AL
Sbjct: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605
Query: 345 EV 346
++
Sbjct: 1606 DL 1607
Score = 77.4 bits (189), Expect = 6e-14
Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%)
Query: 186 NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 241
NLG + +G + LAI A+++D N A+ N + R A+ Y
Sbjct: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIV 1259
Query: 242 LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 297
L L V N +Y E G A++ +++A L + C+ +
Sbjct: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318
Query: 298 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 354
EA + + AL++ P D+ N E G+ E +A + + KAL + P + A
Sbjct: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
Query: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 407
+ LQ QGK Q+A H+ AI P AY MGN MQD+ A++
Sbjct: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
Query: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 458
T A + +N IH+ G+ A+ Y+ A+ L P + AY N
Sbjct: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481
Score = 73.6 bits (179), Expect = 9e-13
Identities = 67/286 (23%), Positives = 128/286 (44%), Gaps = 9/286 (3%)
Query: 173 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 229
AI N A+ N + E+ +A+ + + LD L+ ++N G + E
Sbjct: 1225 AISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
Query: 230 IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288
+ A+ + +A +S N ++ H C ++ + A++ + A+++ P F DAY
Sbjct: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
Query: 289 LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
N+ E G + +A+ + AL + P + + + + QG ++A + A++
Sbjct: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403
Query: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
P+ A+ A V Q G A+ A++IS T A+ +N G + M Q A+
Sbjct: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462
Query: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
+ Y AI +NP ++ A+ N +I+ +A + ALK P+
Sbjct: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508
Score = 66.2 bits (160), Expect = 1e-10
Identities = 89/422 (21%), Positives = 167/422 (39%), Gaps = 59/422 (13%)
Query: 79 AEAYSNLGNVYKERGQLQE----AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134
A+ NLG Y E G LQ AI A+ + + + N A +++ A+
Sbjct: 1195 ADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALT 1254
Query: 135 AY--------VSALQYNPDLY--CVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAW 184
Y ++ N L + +LG AL ++A A+ ++ N ++
Sbjct: 1255 DYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQA------ALISRTNGSLCH 1308
Query: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEA---RIFDRAVAAYLRA 241
+ C + E A++ F A+ ++P FLDAY+ GN E +A +L+A
Sbjct: 1309 ATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKA 1367
Query: 242 LSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAE 301
L ++P + + QG A + + AI+ P AY A + G+
Sbjct: 1368 LHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFA 1427
Query: 302 AEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL 361
A N A+++ T A+ L N I G+ + A++ Y+ A+ + P+++ A+ N ++
Sbjct: 1428 AMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIY 1486
Query: 362 QQQGKLQEALMHYKEAIRISPT----------------------------------FADA 387
+ +A ++ +A++ P +A
Sbjct: 1487 FHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAV 1546
Query: 388 YSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALK 447
Y N + ++ + A + +A+ + P A ++ A + G I EA+A Y AL
Sbjct: 1547 YFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD 1606
Query: 448 LK 449
L+
Sbjct: 1607 LE 1608
Score = 57.4 bits (137), Expect = 7e-08
Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%)
Query: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 138
A AY G +Y++ G+LQ A+ + + L+P F++ Y + + + A+
Sbjct: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
Query: 139 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 198
+YN + + + + A Y +AI++ P A + G ++ ++
Sbjct: 977 IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035
Query: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 256
LAI F K + DP DA + G E + A+ + L++ ++ G L
Sbjct: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095
Query: 257 CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 288
YY +Q LI + + +AIE+ C
Sbjct: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155
Query: 289 LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 337
L ++ K EA + AL AD L NL E+GN++
Sbjct: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
Query: 338 RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 390
+L A+ + A N A + +LQ AL Y + + T + + N
Sbjct: 1216 KLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 391 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
G E+ AL+ + +A I+ A H EA+ + ALK+ P
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
Query: 451 DFPDAY 456
F DAY
Sbjct: 1336 CFLDAY 1341
Score = 36.2 bits (82), Expect = 0.16
Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385
I R+ G ++ A+ ++ + + P F A+ + + Q K+ EAL + +
Sbjct: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+AY + + +D+ A+ YT+AI+ P AD + +++ + + AI +
Sbjct: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044
Query: 446 LKLKPDFPDA-------YCNLAHCLQIVCDWT 470
+ P DA YC + + D+T
Sbjct: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 79.3 bits (194), Expect = 2e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 44 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 97
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 240 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 299
Query: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 152
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 300 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 358
Query: 153 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 202
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 359 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 418
Query: 203 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 234
+ E A L+ N Y+ NL + + F +A
Sbjct: 419 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 478
Query: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 479 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 538
Query: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 539 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 598
Query: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 414
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 599 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 658
Query: 415 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 472
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 659 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 718
Query: 473 DERMKKL 479
++K+L
Sbjct: 719 ARKLKRL 725
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 79.3 bits (194), Expect = 2e-14
Identities = 105/487 (21%), Positives = 191/487 (39%), Gaps = 52/487 (10%)
Query: 44 NTGVLLL-LSSIHFQCRRLDRSAHFSTLAIKQNP-----LLAEAYSNLGNVYKERGQLQE 97
N G+L + + +I+ + R ++ F +A+ Q P + + N+G + + GQ +
Sbjct: 231 NAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSD 290
Query: 98 AIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA----LQYNPDLYCVRSD- 152
AI Y H + + P+ GY NL A GD E +A+ L+ + D Y SD
Sbjct: 291 AINSYEHIMSMAPNLKAGY-NLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDD 349
Query: 153 -LGNLLKA------LGRLE-EAKACYLKAIETQPNFA--VAWSNLGCVFNAQGEIWLAIH 202
NL+ L ++E E KA K I T V ++ ++ E+ A
Sbjct: 350 PHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQ 409
Query: 203 HFEKAVTLDPNFLDAYI----------------------------NLGNVLKEARIFDRA 234
+ E A L+ N Y+ NL + + F +A
Sbjct: 410 YVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQA 469
Query: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
+ A++ + N + G + A + Y+ A+ +A N+ +
Sbjct: 470 SSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYE 529
Query: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
+ + EA DC+ + A+ L +ANI N +A+ + + V P
Sbjct: 530 KLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVL 589
Query: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI 414
S L + ++G +A +Y E+ R P + +G + Q + A+Q + RA I
Sbjct: 590 SKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLI 649
Query: 415 NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH-CLQI-VCDWTDY 472
P +AS + SGN +A+ +Y+ + P+ + L C + + D +Y
Sbjct: 650 QPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEY 709
Query: 473 DERMKKL 479
++K+L
Sbjct: 710 ARKLKRL 716
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 79.0 bits (193), Expect = 2e-14
Identities = 61/258 (23%), Positives = 114/258 (44%), Gaps = 1/258 (0%)
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
LGN + + FD A+ Y +A L P + N A VY+E+G + + +AIE+
Sbjct: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 340
+ Y +A A G+ E+ Y A+ + + + ++ ++ E+ ++
Sbjct: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTPDVLKKCQQAEKILKEQ 349
Query: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
+ + P+ A N + Q+G +A+ HY EAI+ +P A YSN ++ +
Sbjct: 350 ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409
Query: 401 VQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLA 460
Q AL+ IQ+ P F ++ A+ + + +A+ Y+ AL L +A
Sbjct: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQ 469
Query: 461 HCLQIVCDWTDYDERMKK 478
C+ + D E +K+
Sbjct: 470 RCMMAQYNRHDSPEDVKR 487
Score = 76.6 bits (187), Expect = 1e-13
Identities = 96/423 (22%), Positives = 163/423 (38%), Gaps = 30/423 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
AIK +P YSN Y ++G Q+A E + LKPD+ GY AAAL E
Sbjct: 30 AIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFE 89
Query: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC-------YLKAIETQPNFAVA 183
A + Y L++ + ++ L N+ RL E K + +E+ P
Sbjct: 90 EAKRTYEEGLKHEANNPQLKEGLQNM---EARLAERKFMNPFNMPNLYQKLESDPRTRTL 146
Query: 184 WSN------LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIF------ 231
S+ + + N ++ + TL + ++LG++ +E I
Sbjct: 147 LSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS---VLLGVDLGSMDEEEEIATPPPPP 203
Query: 232 ----DRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYC 287
+ L + A+ L Y++ D A+ Y +A EL P
Sbjct: 204 PPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYIT 263
Query: 288 NLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVF 347
N A EKG + + A+ + + + +A GN Y+ A+ +
Sbjct: 264 NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFY 323
Query: 348 PEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQC 407
+ A H VL++ + ++ L + I+P A N GN + D A++
Sbjct: 324 NKSLAEH-RTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKH 382
Query: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVC 467
YT AI+ NP A +SN A+ + A+ ++L+P F Y A L+ +
Sbjct: 383 YTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMK 442
Query: 468 DWT 470
D+T
Sbjct: 443 DYT 445
Score = 72.0 bits (175), Expect = 3e-12
Identities = 72/308 (23%), Positives = 123/308 (39%), Gaps = 23/308 (7%)
Query: 16 ELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQ------CRRL-DRSAHFS 68
EL + Y+ DF+ A +H + +P N + ++++F+ CR L +++
Sbjct: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289
Query: 69 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHAL--RLKPDFIDGYINLAAALVAA 126
+ +A+AY+ +GN Y + + ++AI Y +L PD L
Sbjct: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPD----------VLKKC 339
Query: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
E ++ NPDL + GN G +A Y +AI+ P A +SN
Sbjct: 340 QQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSN 399
Query: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL-S 245
+ E LA+ E+ + L+P F+ Y L+ + + +A+ Y +AL L S
Sbjct: 400 RAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDS 459
Query: 246 PNHAVVHGNLACVYYEQGLIDLAIDTYRRAI---ELQPHFPDAYCNLANALKEKGSVAEA 302
G C+ + D D RRA+ E+Q D L +K A +
Sbjct: 460 SCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALS 519
Query: 303 EDCYNTAL 310
E N +
Sbjct: 520 EHLKNPVI 527
Score = 57.0 bits (136), Expect = 9e-08
Identities = 68/308 (22%), Positives = 118/308 (38%), Gaps = 9/308 (2%)
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 131
+ +N A LGN ++ A++HY A L P + N AA GD
Sbjct: 218 LPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNK 277
Query: 132 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEA---KACYLKAIETQPNFAVAWSNLG 188
+ A++ + R D + KA R+ + + Y AI N ++A
Sbjct: 278 CRELCEKAIEVGREN---REDYRQIAKAYARIGNSYFKEEKYKDAIHFY-NKSLAEHRTP 333
Query: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH 248
V + + E+ ++P+ N GN + + +A+ Y A+ +P
Sbjct: 334 DVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKD 393
Query: 249 AVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNT 308
A ++ N A Y + LA+ I+L+P F Y A AL+ +A D Y
Sbjct: 394 AKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQK 453
Query: 309 ALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLAS--VLQQQGK 366
AL L + ++ + Q N ++ ++ PE S+ A +L+Q K
Sbjct: 454 ALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQK 513
Query: 367 LQEALMHY 374
+AL +
Sbjct: 514 DPQALSEH 521
Score = 51.2 bits (121), Expect = 5e-06
Identities = 79/393 (20%), Positives = 134/393 (34%), Gaps = 84/393 (21%)
Query: 154 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 213
GN ++G +++A CY +AI+ P+ V +SN + +G+ A K V L P+
Sbjct: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
Query: 214 FLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVH---GNLACVYYEQGLID---- 266
+ Y L+ F+ A Y L N+ + N+ E+ ++
Sbjct: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNM 130
Query: 267 ------LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSL 320
L D R + P + + L N + G+ + T L S+
Sbjct: 131 PNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSM 190
Query: 321 NNLANI-------------------------------KREQGN-------IEEAVRLYRK 342
+ I ++E GN + A++ Y K
Sbjct: 191 DEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDK 250
Query: 343 ALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS-------PTFADAYSNMGNT- 394
A E+ P +N A+V ++G + ++AI + A AY+ +GN+
Sbjct: 251 AKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSY 310
Query: 395 -------------------------LKEMQDVQGALQCYTRAIQINPAFADAHSNLASIH 429
LK+ Q + L+ R INP A N +
Sbjct: 311 FKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNEC 370
Query: 430 KDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 462
G+ P+A+ Y A+K P Y N A C
Sbjct: 371 FQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAAC 403
Score = 42.7 bits (99), Expect = 0.002
Identities = 30/117 (25%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 291 NALKEKGSVA-------EAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKA 343
N LKEKG+ A +A CY+ A++L P + +N + ++G+ ++A K
Sbjct: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
Query: 344 LEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR---ISPTFADAYSNMGNTLKE 397
+++ P++ +S A+ L+ + +EA Y+E ++ +P + NM L E
Sbjct: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAE 121
Score = 40.8 bits (94), Expect = 0.007
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 4/90 (4%)
Query: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
GN + ++ ALQCY+ AI+++P +SN ++ + G+ +A + LKPD
Sbjct: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
Query: 452 FPDAYCNLAHCLQIVCDWTD----YDERMK 477
+ Y A L+ + + + Y+E +K
Sbjct: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLK 100
Score = 40.0 bits (92), Expect = 0.011
Identities = 27/94 (28%), Positives = 42/94 (44%)
Query: 86 GNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPD 145
GN G + +A++ Y A++L P Y N +AA GD + A + + PD
Sbjct: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
Query: 146 LYCVRSDLGNLLKALGRLEEAKACYLKAIETQPN 179
S L+ L R EEAK Y + ++ + N
Sbjct: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEAN 104
Score = 37.7 bits (86), Expect = 0.057
Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 3/111 (2%)
Query: 318 DSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEA 377
+ L N GNI++A++ Y +A+++ P +SN ++ ++G Q+A +
Sbjct: 5 NELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKT 64
Query: 378 IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ---INPAFADAHSNL 425
+ + P + YS L+ + + A + Y ++ NP + N+
Sbjct: 65 VDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNM 115
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 77.0 bits (188), Expect = 8e-14
Identities = 53/222 (23%), Positives = 103/222 (46%), Gaps = 6/222 (2%)
Query: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238
N AW G F+ Q E +AI F++A+ +DPN+ AY LG+ D+A+A +
Sbjct: 571 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 630
Query: 239 LRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGS 298
A+ ++P H L +YY+Q LA +++A+++ P C++
Sbjct: 631 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKK 690
Query: 299 VAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLA 358
+A D N A+ + P + + A++ + A++ + ++ P+ + + +
Sbjct: 691 SEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIG 750
Query: 359 SVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
V ++ G+ ALM++ A+ + P A+ N +KE D
Sbjct: 751 KVYKKLGQTHLALMNFSWAMDLDPKGAN------NQIKEAID 786
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/211 (24%), Positives = 96/211 (45%)
Query: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAI 269
+D N +A+ GN R D A+ + RA+ + PN+A + L + +D A+
Sbjct: 568 MDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKAL 627
Query: 270 DTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKRE 329
+R AI + P +A+ L ++ + AE + AL + P + L ++ ++
Sbjct: 628 ACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHA 687
Query: 330 QGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS 389
E+A+ KA+ + P+ + ASVL K + AL +E +I P + Y
Sbjct: 688 LKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYF 747
Query: 390 NMGNTLKEMQDVQGALQCYTRAIQINPAFAD 420
+G K++ AL ++ A+ ++P A+
Sbjct: 748 LIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 778
Score = 60.8 bits (146), Expect = 6e-09
Identities = 44/201 (21%), Positives = 92/201 (45%)
Query: 80 EAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA 139
EA+ GN + + + AI+ ++ A+++ P++ Y L V +++ A+ + +A
Sbjct: 574 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 633
Query: 140 LQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWL 199
++ NP Y LG + + A+ + KA++ P +V ++G V +A +
Sbjct: 634 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 693
Query: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259
A+ KA+ +DP + +VL + A+ + P ++V+ + VY
Sbjct: 694 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 753
Query: 260 YEQGLIDLAIDTYRRAIELQP 280
+ G LA+ + A++L P
Sbjct: 754 KKLGQTHLALMNFSWAMDLDP 774
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 7/237 (2%)
Query: 108 LKPDFIDGYINLAAALVAAGDM-------EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
L D D N A AAG+ + A++ + A+Q +P+ + LG+
Sbjct: 561 LSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLT 620
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
L++A AC+ AI P AW LG ++ Q + LA HF+KA+ ++P +
Sbjct: 621 EELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 680
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
+G V + ++A+ +A+ + P + + + A V + A+ ++ P
Sbjct: 681 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 740
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAV 337
Y + K+ G A ++ A+ L P A++ A KR + EE +
Sbjct: 741 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPI 797
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/185 (24%), Positives = 85/185 (45%)
Query: 266 DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLAN 325
D+AI ++RAI++ P++ AY L + + +A C+ A+R+ P H ++ L
Sbjct: 590 DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGM 649
Query: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385
I +Q A ++KAL++ P+ + ++ V K ++AL +AI I P
Sbjct: 650 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNP 709
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+ + L + + ALQ QI P + + + ++K G A+ ++ A
Sbjct: 710 LCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWA 769
Query: 446 LKLKP 450
+ L P
Sbjct: 770 MDLDP 774
Score = 50.4 bits (119), Expect = 8e-06
Identities = 46/191 (24%), Positives = 78/191 (40%)
Query: 59 RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYIN 118
R D + F AI+ +P A AY+ LG+ + +L +A+ +R+A+R+ P + +
Sbjct: 587 REHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYG 646
Query: 119 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 178
L A + AL NP + +G + AL + E+A KAI P
Sbjct: 647 LGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 706
Query: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238
+ + V A + A+ E+ + P Y +G V K+ A+ +
Sbjct: 707 KNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNF 766
Query: 239 LRALSLSPNHA 249
A+ L P A
Sbjct: 767 SWAMDLDPKGA 777
Score = 47.0 bits (110), Expect = 9e-05
Identities = 49/216 (22%), Positives = 93/216 (43%), Gaps = 25/216 (11%)
Query: 261 EQGLIDLAIDTY--RRAIELQPHFPDAY-------CNLANALKEKGSVAEAEDCYNTALR 311
E G LA+ +Y + AI + H P + C + A E +AE ++ R
Sbjct: 474 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRR 533
Query: 312 LCPTHADSLN----NLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQ 363
+ + + L +++++ A+ + K L PE A N S LQ+
Sbjct: 534 IENYRVEGMEIYSTTLWHLQKDV-----ALSVLSKDLTDMDKNSPEAWCAAGNCFS-LQR 587
Query: 364 QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS 423
+ + A+ ++ AI++ P +A AY+ +G+ +++ AL C+ AI++NP +A
Sbjct: 588 EHDI--AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWY 645
Query: 424 NLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
L I+ A ++ AL + P C++
Sbjct: 646 GLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 681
Score = 40.4 bits (93), Expect = 0.009
Identities = 41/188 (21%), Positives = 76/188 (40%), Gaps = 6/188 (3%)
Query: 41 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100
+P+ LL LD++ AI+ NP A+ LG +Y ++ + A
Sbjct: 603 DPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM 662
Query: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
H++ AL + P ++ A E A+ A+ +P + ++L A
Sbjct: 663 HFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFAN 722
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
+ + A + + P ++ + +G V+ G+ LA+ +F A+ LDP
Sbjct: 723 EKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK------G 776
Query: 221 LGNVLKEA 228
N +KEA
Sbjct: 777 ANNQIKEA 784
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 77.0 bits (188), Expect = 8e-14
Identities = 53/222 (23%), Positives = 103/222 (46%), Gaps = 6/222 (2%)
Query: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238
N AW G F+ Q E +AI F++A+ +DPN+ AY LG+ D+A+A +
Sbjct: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
Query: 239 LRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGS 298
A+ ++P H L +YY+Q LA +++A+++ P C++
Sbjct: 625 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKK 684
Query: 299 VAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLA 358
+A D N A+ + P + + A++ + A++ + ++ P+ + + +
Sbjct: 685 SEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIG 744
Query: 359 SVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
V ++ G+ ALM++ A+ + P A+ N +KE D
Sbjct: 745 KVYKKLGQTHLALMNFSWAMDLDPKGAN------NQIKEAID 780
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/211 (24%), Positives = 96/211 (45%)
Query: 210 LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAI 269
+D N +A+ GN R D A+ + RA+ + PN+A + L + +D A+
Sbjct: 562 MDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKAL 621
Query: 270 DTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKRE 329
+R AI + P +A+ L ++ + AE + AL + P + L ++ ++
Sbjct: 622 ACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHA 681
Query: 330 QGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS 389
E+A+ KA+ + P+ + ASVL K + AL +E +I P + Y
Sbjct: 682 LKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYF 741
Query: 390 NMGNTLKEMQDVQGALQCYTRAIQINPAFAD 420
+G K++ AL ++ A+ ++P A+
Sbjct: 742 LIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 772
Score = 60.8 bits (146), Expect = 6e-09
Identities = 44/201 (21%), Positives = 92/201 (45%)
Query: 80 EAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSA 139
EA+ GN + + + AI+ ++ A+++ P++ Y L V +++ A+ + +A
Sbjct: 568 EAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNA 627
Query: 140 LQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWL 199
++ NP Y LG + + A+ + KA++ P +V ++G V +A +
Sbjct: 628 IRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
Query: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259
A+ KA+ +DP + +VL + A+ + P ++V+ + VY
Sbjct: 688 ALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVY 747
Query: 260 YEQGLIDLAIDTYRRAIELQP 280
+ G LA+ + A++L P
Sbjct: 748 KKLGQTHLALMNFSWAMDLDP 768
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 7/237 (2%)
Query: 108 LKPDFIDGYINLAAALVAAGDM-------EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
L D D N A AAG+ + A++ + A+Q +P+ + LG+
Sbjct: 555 LSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLT 614
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
L++A AC+ AI P AW LG ++ Q + LA HF+KA+ ++P +
Sbjct: 615 EELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 674
Query: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
+G V + ++A+ +A+ + P + + + A V + A+ ++ P
Sbjct: 675 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 734
Query: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAV 337
Y + K+ G A ++ A+ L P A++ A KR + EE +
Sbjct: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPI 791
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/185 (24%), Positives = 85/185 (45%)
Query: 266 DLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLAN 325
D+AI ++RAI++ P++ AY L + + +A C+ A+R+ P H ++ L
Sbjct: 584 DIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGM 643
Query: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385
I +Q A ++KAL++ P+ + ++ V K ++AL +AI I P
Sbjct: 644 IYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNP 703
Query: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445
+ + L + + ALQ QI P + + + ++K G A+ ++ A
Sbjct: 704 LCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWA 763
Query: 446 LKLKP 450
+ L P
Sbjct: 764 MDLDP 768
Score = 50.4 bits (119), Expect = 8e-06
Identities = 46/191 (24%), Positives = 78/191 (40%)
Query: 59 RRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYIN 118
R D + F AI+ +P A AY+ LG+ + +L +A+ +R+A+R+ P + +
Sbjct: 581 REHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYG 640
Query: 119 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 178
L A + AL NP + +G + AL + E+A KAI P
Sbjct: 641 LGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 700
Query: 179 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAY 238
+ + V A + A+ E+ + P Y +G V K+ A+ +
Sbjct: 701 KNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNF 760
Query: 239 LRALSLSPNHA 249
A+ L P A
Sbjct: 761 SWAMDLDPKGA 771
Score = 47.0 bits (110), Expect = 9e-05
Identities = 49/216 (22%), Positives = 93/216 (43%), Gaps = 25/216 (11%)
Query: 261 EQGLIDLAIDTY--RRAIELQPHFPDAY-------CNLANALKEKGSVAEAEDCYNTALR 311
E G LA+ +Y + AI + H P + C + A E +AE ++ R
Sbjct: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRR 527
Query: 312 LCPTHADSLN----NLANIKREQGNIEEAVRLYRKALEVF----PEFAAAHSNLASVLQQ 363
+ + + L +++++ A+ + K L PE A N S LQ+
Sbjct: 528 IENYRVEGMEIYSTTLWHLQKDV-----ALSVLSKDLTDMDKNSPEAWCAAGNCFS-LQR 581
Query: 364 QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHS 423
+ + A+ ++ AI++ P +A AY+ +G+ +++ AL C+ AI++NP +A
Sbjct: 582 EHDI--AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWY 639
Query: 424 NLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
L I+ A ++ AL + P C++
Sbjct: 640 GLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHI 675
Score = 40.4 bits (93), Expect = 0.009
Identities = 41/188 (21%), Positives = 76/188 (40%), Gaps = 6/188 (3%)
Query: 41 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100
+P+ LL LD++ AI+ NP A+ LG +Y ++ + A
Sbjct: 597 DPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEM 656
Query: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
H++ AL + P ++ A E A+ A+ +P + ++L A
Sbjct: 657 HFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFAN 716
Query: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
+ + A + + P ++ + +G V+ G+ LA+ +F A+ LDP
Sbjct: 717 EKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPK------G 770
Query: 221 LGNVLKEA 228
N +KEA
Sbjct: 771 ANNQIKEA 778
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 75.9 bits (185), Expect = 2e-13
Identities = 93/458 (20%), Positives = 183/458 (39%), Gaps = 40/458 (8%)
Query: 40 QEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP-LLAEAYSNLGNVYKERGQLQEA 98
Q P+N LL + I F + + + A++ NP AE +G+ + + +L++A
Sbjct: 158 QSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA 217
Query: 99 IEHYRHALRLKPDFIDGYINLAAALV---AAGDMEGAVQAYVSALQYNPDLYCVRSDLGN 155
+ AL L + + LA + A ++ VQ A +P V + L N
Sbjct: 218 RLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLAN 277
Query: 156 ---LLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTL-D 211
K +++ E + A + L F+ Q + A ++ +A
Sbjct: 278 HFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFAS 337
Query: 212 PNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNH---AVVHGNLACVYYEQGLIDLA 268
+F+ + LG + + A + + L PN+ + G+L +Q D+A
Sbjct: 338 SSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIA 397
Query: 269 IDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS------LNN 322
++ E P +A+ LA L E+ + A Y TA R+ + LNN
Sbjct: 398 KGHLKKVTEQYPDDVEAWIELAQIL-EQTDIQGALSAYGTATRILQEKVQADVPPEILNN 456
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISP 382
+ + GN+ EA + + +L+ + A H HY AI ++
Sbjct: 457 VGALHFRLGNLGEAKKYFLASLDR-AKAEAEHDE----------------HYYNAISVTT 499
Query: 383 TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASY 442
++ N+ + M + A + Y ++ +P + D + L ++ +D GN EA +
Sbjct: 500 SY-----NLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWF 554
Query: 443 RTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLV 480
+ AL++ D PDA+ + + +W ++ ++++
Sbjct: 555 KEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERIL 592
Score = 72.8 bits (177), Expect = 2e-12
Identities = 80/362 (22%), Positives = 151/362 (41%), Gaps = 33/362 (9%)
Query: 75 NPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134
NP++ +N K+ ++Q H H ++ + LA + D + A Q
Sbjct: 268 NPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQ 327
Query: 135 AYVSALQYNPDLYCVRS-DLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNA 193
Y A Q+ + + LG + G E A C+ K ++ PN LG ++ A
Sbjct: 328 YYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAA 387
Query: 194 ---QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 250
Q + +A H +K P+ ++A+I L +L++ I A++AY A +
Sbjct: 388 SEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDI-QGALSAYGTATRILQEKVQ 446
Query: 251 ------VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 304
+ N+ +++ G + E + +F LA+ + K AE ++
Sbjct: 447 ADVPPEILNNVGALHFRLGNLG----------EAKKYF------LASLDRAKAE-AEHDE 489
Query: 305 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 364
Y A+ + ++ NLA + EA +LY+ L P + + L ++ + +
Sbjct: 490 HYYNAISVTTSY-----NLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDK 544
Query: 365 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 424
G EA +KEA++I+ DA+S +GN Q+ + + R ++ +D +S
Sbjct: 545 GNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSM 604
Query: 425 LA 426
LA
Sbjct: 605 LA 606
Score = 62.8 bits (151), Expect = 2e-09
Identities = 88/416 (21%), Positives = 161/416 (38%), Gaps = 48/416 (11%)
Query: 25 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHF----QCRRLDRSAHFSTLAIKQNPLLAE 80
GD E A + ++ + P+N + +L S++ Q +R H + +Q P E
Sbjct: 355 GDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVT-EQYPDDVE 413
Query: 81 AYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYI------NLAAALVAAGDMEGAVQ 134
A+ L + E+ +Q A+ Y A R+ + + + N+ A G++ A +
Sbjct: 414 AWIELAQIL-EQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKK 472
Query: 135 AYVSALQ------------YNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAV 182
++++L YN +L L +A+ EA+ Y + PN+
Sbjct: 473 YFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVD 532
Query: 183 AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRAL 242
+ LG + +G + A F++A+ ++ + DA+ +GN+ + + + R L
Sbjct: 533 CYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERIL 592
Query: 243 SLSPNHAVVHGNLACVYY--------------EQGLIDLAIDTYRRAIELQPHFPDAYCN 288
+ + LA E+ D A+ Y++ + A
Sbjct: 593 KQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANG 652
Query: 289 LANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFP 348
+ L KG EA D + +D NLA+I EQ AV++Y L F
Sbjct: 653 IGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFY 712
Query: 349 EFAAAHSN------LASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEM 398
+ H N LA L + GKLQE +A ++P+ N+ L+ +
Sbjct: 713 K----HQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRL 764
Score = 43.9 bits (102), Expect = 8e-04
Identities = 54/258 (20%), Positives = 104/258 (40%), Gaps = 16/258 (6%)
Query: 205 EKAVTLDPNFLDAYINLGNV---LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 261
+K + D N L LG L E D+A A + L+ SPN+ AC+ +
Sbjct: 121 DKIIMYDQNHL-----LGRACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFN 175
Query: 262 QGLIDLAIDTYRRAIELQPHFP-DAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSL 320
+ A+ Y++A+ P P + + + + + +A ++ AL L +L
Sbjct: 176 KKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGAL 235
Query: 321 NNLANIK---REQGNIEEAVRLYRKALEVFPEFAAAHSNLAS---VLQQQGKLQEALMHY 374
LA ++ +E +I+ V+L +A + P ++LA+ + K+Q +H
Sbjct: 236 VGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHA 295
Query: 375 KEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI-NPAFADAHSNLASIHKDSG 433
+ A++ + + +D A Q Y +A Q + +F L ++ G
Sbjct: 296 FHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRG 355
Query: 434 NIPEAIASYRTALKLKPD 451
+ A + LK P+
Sbjct: 356 DKENASQCFEKVLKAYPN 373
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 72.0 bits (175), Expect = 3e-12
Identities = 58/267 (21%), Positives = 119/267 (44%), Gaps = 6/267 (2%)
Query: 87 NVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDL 146
N K Q + E R D + + +A L+ +G + A++ + + LQ PDL
Sbjct: 117 NTEKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDL 176
Query: 147 YCVRSDLGNLL--KALGRLEEAKACYL---KAIETQPNFAVAWSNLGCVFNAQGEIWLAI 201
G K L ++ A+ + I +P+ + + + G I A+
Sbjct: 177 VSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAV 236
Query: 202 HHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYE 261
+ KA+ L P+ Y + G + + + A + ++L L+ N + ++
Sbjct: 237 NDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFH 295
Query: 262 QGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLN 321
+GL+ AI++++ A++ + F DAY +L A +E G+ A + + AL L H +L
Sbjct: 296 RGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQ 355
Query: 322 NLANIKREQGNIEEAVRLYRKALEVFP 348
+ G+++EA++ +++ L++ P
Sbjct: 356 LRGMMLYHHGSLQEALKNFKRCLQLEP 382
Score = 71.6 bits (174), Expect = 4e-12
Identities = 56/221 (25%), Positives = 98/221 (44%), Gaps = 7/221 (3%)
Query: 66 HFSTLAIKQNPLLAEAYSNLGNVYKERG-----QLQEAIEHYRHALRLKPDFIDGYINLA 120
HFST+ +++ P L A G Y ++G + A+ + L+PD + + A
Sbjct: 165 HFSTM-LQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRA 223
Query: 121 AALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNF 180
L G + AV A+Q P R G L A + +++E N
Sbjct: 224 EILSPLGRINEAVNDLTKAIQLQPSARLYRHR-GTLYFISEDYATAHEDFQQSLELNKNQ 282
Query: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLR 240
+A G F +G + AI F++A+ +F+DAY +LG +E F+ A ++ +
Sbjct: 283 PIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQK 342
Query: 241 ALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH 281
AL L+ NH + Y G + A+ ++R ++L+P+
Sbjct: 343 ALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPY 383
Score = 68.2 bits (165), Expect = 4e-11
Identities = 57/246 (23%), Positives = 107/246 (43%), Gaps = 25/246 (10%)
Query: 217 AYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLID-----LAIDT 271
AY+ +G+ L +D A+ + L P+ Y ++GL D LA+
Sbjct: 150 AYVLIGSGL-----YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFE 204
Query: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
R I L+P P+ + A L G + EA + A++L P+ A + R +G
Sbjct: 205 LSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS--------ARLYRHRG 256
Query: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQ-------QQGKLQEALMHYKEAIRISPTF 384
+ Y A E F + + N + +G L+EA+ +KEA++ F
Sbjct: 257 TLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDF 316
Query: 385 ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT 444
DAY ++G +E+ + + A + + +A+ +N + G++ EA+ +++
Sbjct: 317 IDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKR 376
Query: 445 ALKLKP 450
L+L+P
Sbjct: 377 CLQLEP 382
Score = 60.5 bits (145), Expect = 8e-09
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 2/144 (1%)
Query: 69 TLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGD 128
+L + +N +A Y L + RG L+EAIE ++ AL+ K DFID Y +L A G+
Sbjct: 275 SLELNKNQPIAMLYKGL--TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGN 332
Query: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
E A +++ AL N + G +L G L+EA + + ++ +P V G
Sbjct: 333 FEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKG 392
Query: 189 CVFNAQGEIWLAIHHFEKAVTLDP 212
A G+ + I K + DP
Sbjct: 393 LSHVAMGQFYEGIKAQTKVMLNDP 416
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/194 (23%), Positives = 90/194 (46%), Gaps = 7/194 (3%)
Query: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
N E A+ + + + P+ A +L G++ EA+ +AI++ P+ A Y +
Sbjct: 197 NAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHR 255
Query: 392 GNTLKEMQDVQGALQCYTRAIQINP--AFADAHSNLASIHKDSGNIPEAIASYRTALKLK 449
G +D A + + +++++N A + L H+ G + EAI S++ ALK K
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHR--GLLKEAIESFKEALKQK 313
Query: 450 PDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVH-PHHSMLYPLSHG 508
DF DAY +L + + ++ E +K + + + ++ +L + HH L
Sbjct: 314 VDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 373
Query: 509 FRKAI-AERHGNLC 521
F++ + E + +C
Sbjct: 374 FKRCLQLEPYNEVC 387
Score = 52.0 bits (123), Expect = 3e-06
Identities = 54/262 (20%), Positives = 104/262 (39%), Gaps = 15/262 (5%)
Query: 24 AGDFEAAERHCMQLWRQEPD------NTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPL 77
+G ++ A RH + ++EPD G+ +H + + + + I P
Sbjct: 156 SGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLH-DIKNAELALFELSRVITLEPD 214
Query: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYV 137
E + + G++ EA+ A++L+P Y + + D A + +
Sbjct: 215 RPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQ 273
Query: 138 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 197
+L+ N + G G L+EA + +A++ + +F A+ +LG + G
Sbjct: 274 QSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 333
Query: 198 WLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLAC 257
A F+KA+ L+ N + G +L A+ + R L L P + V
Sbjct: 334 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQ----- 388
Query: 258 VYYEQGLIDLAIDTYRRAIELQ 279
Y +GL +A+ + I+ Q
Sbjct: 389 --YMKGLSHVAMGQFYEGIKAQ 408
Score = 33.9 bits (76), Expect = 0.82
Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 5/99 (5%)
Query: 357 LASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMG-----NTLKEMQDVQGALQCYTRA 411
+A VL G EA+ H+ ++ P A G L ++++ + AL +R
Sbjct: 149 IAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRV 208
Query: 412 IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450
I + P + A I G I EA+ A++L+P
Sbjct: 209 ITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQP 247
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 70.1 bits (170), Expect = 1e-11
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 33/322 (10%)
Query: 88 VYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY 147
+++ G +QE++E ++ L P D +A +L G + A++ Y A + N +
Sbjct: 76 IFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDW 135
Query: 148 CVRSDLG--------------NLLKAL-------------------GRLEEAKACYLKAI 174
+ +LG L AL G L++A Y KA+
Sbjct: 136 EISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAV 195
Query: 175 ETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 234
E P + LG ++ G A H A+T DP A + G++++ FD A
Sbjct: 196 EFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVA 255
Query: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALK 294
+ Y P + N+ ++ + AI +RA L P NL
Sbjct: 256 LTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHL 315
Query: 295 EKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAH 354
A A + A+ P + LA +IE A R Y +A+ + +
Sbjct: 316 TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVN 375
Query: 355 SNLASVLQQQGKLQEALMHYKE 376
N A +L QG+ + AL Y+E
Sbjct: 376 LNYAVLLYNQGEKKNALAQYQE 397
Score = 62.0 bits (149), Expect = 3e-09
Identities = 67/277 (24%), Positives = 109/277 (39%), Gaps = 11/277 (3%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A K N E NLG Y Q +A + +AL L + YI L + GD++
Sbjct: 127 AAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLT-YIMLGKIHLLEGDLD 185
Query: 131 GAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCV 190
A++ Y A++++P+ + + LG L LG ++A A+ P A G +
Sbjct: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
Query: 191 FNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAV 250
G+ +A+ + P + N+G + + A++ RA L+P
Sbjct: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWK 305
Query: 251 VHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTAL 310
+ NL V+ A AI QP + Y LA AL + A+ Y A+
Sbjct: 306 ILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAV 365
Query: 311 RLCPTHADSLNNLANIK-----REQGNIEEAVRLYRK 342
H D N L N+ QG + A+ Y++
Sbjct: 366 -----HLDKCNPLVNLNYAVLLYNQGEKKNALAQYQE 397
Score = 62.0 bits (149), Expect = 3e-09
Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 6/228 (2%)
Query: 49 LLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL 108
++L IH LD++ A++ +P E + LG +Y + G Q+A EH +AL
Sbjct: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231
Query: 109 KPDFIDGYINLAAALVAAGDMEGAVQAY---VSALQYNPDLYCVRSDLGNLLKALGRLEE 165
P + + + GD + A+ Y A+ +P L+ +++G +
Sbjct: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLW---NNIGMCFFGKKKYVA 288
Query: 166 AKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVL 225
A +C +A P NLG V + A H A+ P + Y+ L L
Sbjct: 289 AISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVAL 348
Query: 226 KEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYR 273
+ A AY A+ L + +V+ N A + Y QG A+ Y+
Sbjct: 349 TNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ 396
Score = 60.1 bits (144), Expect = 1e-08
Identities = 67/290 (23%), Positives = 117/290 (40%), Gaps = 6/290 (2%)
Query: 200 AIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY 259
AI + +A L+ + NLG + F++A AL+L+ H + + L ++
Sbjct: 120 AIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIH 178
Query: 260 YEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS 319
+G +D AI+ Y++A+E P + L + G +A + AL PT+ +
Sbjct: 179 LLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKA 238
Query: 320 LNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIR 379
+ ++ + G+ + A+ YR PE +N+ + K A+ K A
Sbjct: 239 ILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANY 298
Query: 380 ISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAI 439
++P N+G MQ A + AI P + + LA + +I A
Sbjct: 299 LAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAK 358
Query: 440 ASYRTALKLKPDFPDAYCNLAHCLQIVCD----WTDYDERMKKLVSIVAD 485
+Y A+ L P N A L + Y E M+K VS++ D
Sbjct: 359 RAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQE-MEKKVSLLKD 407
Score = 49.7 bits (117), Expect = 1e-05
Identities = 45/214 (21%), Positives = 84/214 (39%), Gaps = 15/214 (7%)
Query: 256 ACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPT 315
A ++ +G I +++ ++ L P D +A +L G A + YN A +L
Sbjct: 74 ALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQK 133
Query: 316 HADSLNNLA-------NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQ 368
+ +NL + Q + A+ L R L + L + +G L
Sbjct: 134 DWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL--------TYIMLGKIHLLEGDLD 185
Query: 369 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 428
+A+ YK+A+ SP + + +G ++ Q A + A+ +P A S+
Sbjct: 186 KAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSM 245
Query: 429 HKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC 462
+ G+ A+ YR P+ P + N+ C
Sbjct: 246 MQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC 279
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/317 (23%), Positives = 129/317 (40%), Gaps = 28/317 (8%)
Query: 154 GNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPN 213
GN A EA Y KAI+ P A + N G A+ +++V LD +
Sbjct: 35 GNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDS 94
Query: 214 FL-------DAYINLGNVLKEARIFDRAVA-----AYLRALSLSPNHAVVHGNLACVYYE 261
F+ +++LGN + R F RA+ A + + N + + +A +E
Sbjct: 95 FVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFE 154
Query: 262 QGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLN 321
+ + RA+E P A L G EA+ + LR+ T+AD+L
Sbjct: 155 KRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALY 214
Query: 322 NLANIKREQGNIEEAVRLYRKALEVFP--EFAAAHSNLASVLQ----------QQGKLQE 369
+ IE+AV+ + +AL + P E A A L+ ++G +
Sbjct: 215 VRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKL 274
Query: 370 ALMHYKEAIRISP----TFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNL 425
A Y EA+ I P T A Y N G +++ + A++ T A++++ + A+
Sbjct: 275 AYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRR 334
Query: 426 ASIHKDSGNIPEAIASY 442
A + D+ EA+ Y
Sbjct: 335 AQCYMDTEQYEEAVRDY 351
Score = 47.8 bits (112), Expect = 5e-05
Identities = 72/345 (20%), Positives = 131/345 (37%), Gaps = 44/345 (12%)
Query: 66 HFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVA 125
++ T AI P A Y N G+ +EA+ + ++RL F+ G++ ++
Sbjct: 49 NYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLS 108
Query: 126 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKA------------CYLKA 173
G+ A +++ AL+ + + + N + + A+ C +A
Sbjct: 109 LGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRA 168
Query: 174 IETQP---NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARI 230
+E P F + + + E A + +D DA G L
Sbjct: 169 LEFAPACHRFKILKAECLAMLGRYPE---AQSVASDILRMDSTNADALYVRGLCLYYEDC 225
Query: 231 FDRAVAAYLRALSLSPNHAVV---------------HGNLACVYYEQGLIDLAIDTYRRA 275
++AV +++AL ++P+H GN A +++G LA + Y A
Sbjct: 226 IEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKA---FKEGNYKLAYELYTEA 282
Query: 276 IELQPHF----PDAYCNLANALKEKGSVAEA-EDCYNTALRLCPTHADSLNNLANIKREQ 330
+ + P+ YCN + + +A EDC N A++L T+ + A +
Sbjct: 283 LGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTN-AVKLDDTYIKAYLRRAQCYMDT 341
Query: 331 GNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYK 375
EEAVR Y K + E H L Q + + + +YK
Sbjct: 342 EQYEEAVRDYEKVYQT--EKTKEHKQLLKNAQLELRKSKRKDYYK 384
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/101 (25%), Positives = 51/101 (50%), Gaps = 7/101 (6%)
Query: 328 REQGNI-------EEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
+EQGN EA Y KA+++ P+ A+ + N A+ L G+ +EAL ++++R+
Sbjct: 32 KEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRL 91
Query: 381 SPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADA 421
+F + G + + A + + RA++++ A A
Sbjct: 92 DDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQA 132
Score = 45.8 bits (107), Expect = 2e-04
Identities = 56/285 (19%), Positives = 107/285 (37%), Gaps = 24/285 (8%)
Query: 222 GNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPH 281
GN + ++ A Y +A+ + P +A +GN A G A+ ++++ L
Sbjct: 35 GNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDS 94
Query: 282 FPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKR------------E 329
F + G+ A + AL L +A + N E
Sbjct: 95 FVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFE 154
Query: 330 QGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYS 389
+ + + V +ALE P A L G+ EA + +R+ T ADA
Sbjct: 155 KRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALY 214
Query: 390 NMGNTLKEMQDVQGALQCYTRAIQINP-----AFADAHSNLASIHKDSGNIPEAIASYRT 444
G L ++ A+Q + +A+++ P A ++ K+ GN +Y+
Sbjct: 215 VRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKL 274
Query: 445 ALKLKPDF----PDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD 485
A +L + P+ N+ ++ C+ + +++KL + D
Sbjct: 275 AYELYTEALGIDPN---NIKTNAKLYCNRGTVNSKLRKLDDAIED 316
Score = 37.7 bits (86), Expect = 0.057
Identities = 48/194 (24%), Positives = 74/194 (38%), Gaps = 23/194 (11%)
Query: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA 120
+DR+ F+ + L AE + LG Y E + I LR+ D
Sbjct: 165 MDRALEFAPACHRFKILKAECLAMLGR-YPEAQSVASDI------LRMDSTNADALYVRG 217
Query: 121 AALVAAGDMEGAVQAYVSALQYNPD-----LYC-------VRSDLGNLLKALGRLEEAKA 168
L +E AVQ +V AL+ PD + C + + GN G + A
Sbjct: 218 LCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYE 277
Query: 169 CYLKAIETQPN----FAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224
Y +A+ PN A + N G V + ++ AI AV LD ++ AY+
Sbjct: 278 LYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQC 337
Query: 225 LKEARIFDRAVAAY 238
+ ++ AV Y
Sbjct: 338 YMDTEQYEEAVRDY 351
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/78 (24%), Positives = 32/78 (41%)
Query: 385 ADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRT 444
A+ + GN +D A YT+AI + P A + N A+ G EA+ +
Sbjct: 28 AETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQ 87
Query: 445 ALKLKPDFPDAYCNLAHC 462
+++L F + C
Sbjct: 88 SVRLDDSFVRGHLREGKC 105
>gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
Length = 626
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/225 (28%), Positives = 94/225 (41%), Gaps = 12/225 (5%)
Query: 67 FSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 126
F AI Q+P AEA+ LG E Q AI + L L+P+ + + LA +
Sbjct: 348 FMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 407
Query: 127 GDMEGAVQAYVSALQYNPDL-YCVRSDLGN--LLKALGR-------LEEAKACYLKAIET 176
G + A A + ++ NP Y V+S G+ L + + + LE K YL+A
Sbjct: 408 GHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQ 467
Query: 177 QPNF--AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 234
+ + LG +F+ GE AI F A+T+ P + LG L + A
Sbjct: 468 NGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEA 527
Query: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
V AY RAL + P NL G A+ + A+ LQ
Sbjct: 528 VEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 572
Score = 58.2 bits (139), Expect = 4e-08
Identities = 61/261 (23%), Positives = 101/261 (38%), Gaps = 32/261 (12%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ + I E A+ DP +A+ LG E A+ A R L L PN+
Sbjct: 339 EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALM 398
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLC 313
LA Y G A D + I+ P K K V + R+
Sbjct: 399 ALAVSYTNTGHQQDACDALKNWIKQNP-------------KYKYLVKSKKGSPGLTRRMS 445
Query: 314 PTHADSLNNLANIKREQGNIEEAVRLYRKALE-----VFPEFAAAHSNLASVLQQQGKLQ 368
+ DS +E LY +A + P+ + L + G+
Sbjct: 446 KSPVDS-----------SVLEGVKELYLEAAHQNGDMIDPDL---QTGLGVLFHLSGEFN 491
Query: 369 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 428
A+ + A+ + P ++ +G TL + A++ YTRA++I P F + NL
Sbjct: 492 RAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGIS 551
Query: 429 HKDSGNIPEAIASYRTALKLK 449
+ G EA++++ TAL L+
Sbjct: 552 CINLGAYREAVSNFLTALSLQ 572
Score = 48.1 bits (113), Expect = 4e-05
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 13/208 (6%)
Query: 61 LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH---YRHALRLKPDFIDGYI 117
L R +K LA +Y+N G+ L+ I+ Y++ ++ K
Sbjct: 383 LQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTR 442
Query: 118 NLAAALVAAGDMEGAVQAYVSALQYNPDLYC--VRSDLGNLLKALGRLEEAKACYLKAIE 175
++ + V + +EG + Y+ A N D+ +++ LG L G A + A+
Sbjct: 443 RMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALT 502
Query: 176 TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAV 235
+P W+ LG A+ + +A+ + P F+ + NLG + AV
Sbjct: 503 VRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAV 562
Query: 236 AAYLRALSLSPN--------HAVVHGNL 255
+ +L ALSL H + GN+
Sbjct: 563 SNFLTALSLQRKSRNQQQVPHPAISGNI 590
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/193 (25%), Positives = 81/193 (41%), Gaps = 15/193 (7%)
Query: 30 AERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP----LLAEAYSNL 85
A + C++L +P+N L+ L+ + + IKQNP L+ +
Sbjct: 382 ALQRCLEL---QPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSP 438
Query: 86 GNVYK------ERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--AAGDMEGAVQAYV 137
G + + L+ E Y A D ID + ++ +G+ A+ A+
Sbjct: 439 GLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFN 498
Query: 138 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 197
+AL P+ Y + + LG L R EEA Y +A+E QP F + NLG G
Sbjct: 499 AALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAY 558
Query: 198 WLAIHHFEKAVTL 210
A+ +F A++L
Sbjct: 559 REAVSNFLTALSL 571
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 67.0 bits (162), Expect = 9e-11
Identities = 81/349 (23%), Positives = 138/349 (39%), Gaps = 80/349 (22%)
Query: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID--------GYINLAAALVAAGDM 129
LA+ Y LG K+ G L +AI + +L ++ +D LA+ V
Sbjct: 942 LADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKF 1001
Query: 130 EGAVQAYVSALQYNPDLYCVRSD--------LGNLLKALGRLEEAK-------ACYLKAI 174
A Q Y AL+ + + Y L L + + E+A+ + KAI
Sbjct: 1002 GNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAI 1061
Query: 175 ETQ-------------------------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVT 209
+ + P+ A + LG ++ Q + A ++++
Sbjct: 1062 KKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLE 1121
Query: 210 L--------DPNFLDAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNH---AVVHG 253
+ P+ + NL + E + +D+A Y RAL +L+P+H A
Sbjct: 1122 MRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK 1181
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQ--------PHFPDAYCNLANALKEKGSVAEAEDC 305
+LA +Y + G +D A+ Y A+E++ P A NLA + EA
Sbjct: 1182 HLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPL 1241
Query: 306 YNTAL--------RLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEV 346
Y AL R+ P ++L NLA + E G+ E+A LY++A+E+
Sbjct: 1242 YERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
Score = 53.9 bits (128), Expect = 8e-07
Identities = 71/308 (23%), Positives = 124/308 (40%), Gaps = 72/308 (23%)
Query: 216 DAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNHAVVHGNL---ACVYYEQGLIDL 267
D Y LG LK+ + +A+ R+L +L P+H V +L A VY +
Sbjct: 944 DLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGN 1003
Query: 268 AIDTYRRAIELQP-------------------------------HFPDAYCNL-ANALKE 295
A Y++A+E+ HF + A+K+
Sbjct: 1004 AEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKK 1063
Query: 296 KGSVAEAEDCYNTALRL--------CPTHADSLNNLANIKREQGNIEEAVRLYRKALEV- 346
KG++ AL+L P +A +LN L + Q N+E A + +++LE+
Sbjct: 1064 KGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMR 1123
Query: 347 -------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS--------PTFADAYSNM 391
P+ A + +NLA++ ++ + +A Y+ A+ I P+ A ++
Sbjct: 1124 ERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHL 1183
Query: 392 GNTLKEMQDVQGALQCYTRAIQI--------NPAFADAHSNLASIHKDSGNIPEAIASYR 443
K+M + A+ Y A++I +P+ A A NLA ++ EA+ Y
Sbjct: 1184 AILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYE 1243
Query: 444 TALKLKPD 451
ALK+ D
Sbjct: 1244 RALKIYED 1251
Score = 42.7 bits (99), Expect = 0.002
Identities = 53/232 (22%), Positives = 91/232 (39%), Gaps = 52/232 (22%)
Query: 73 KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALV 124
K P A + LG +Y + L+ A + + +L ++ PD NLAA
Sbjct: 1087 KDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN 1146
Query: 125 AAGDMEGAVQAYVSALQY--------NPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
+ A + Y AL +P L L L K +G+L++A Y A+E
Sbjct: 1147 EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEI 1206
Query: 177 Q--------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA-YINLGNVLKE 227
+ P+ A A NL +++ + A+ +E+A+ + + L + +G LK
Sbjct: 1207 RQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK- 1265
Query: 228 ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
NLA + YE G + A + Y+RA+E++
Sbjct: 1266 --------------------------NLAVLSYEGGDFEKAAELYKRAMEIK 1291
>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 64.7 bits (156), Expect = 4e-10
Identities = 63/226 (27%), Positives = 89/226 (39%), Gaps = 17/226 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++Q+P EA+ LG E Q AI R L LKPD + LA +
Sbjct: 361 AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR 420
Query: 131 GAVQAYVSALQYNPDLYCV---------RSDLGNLLKALGRLE------EAKACYLKAIE 175
A + L+Y P + + LG + LG L E K +L A+
Sbjct: 421 QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR 480
Query: 176 TQPNFAV--AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDR 233
P LG +FN GE A+ F A+++ PN + LG L +
Sbjct: 481 LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE 540
Query: 234 AVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
AVAAY RAL L P + NL G A++ + A+ +Q
Sbjct: 541 AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQ 586
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/238 (23%), Positives = 84/238 (35%), Gaps = 51/238 (21%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ A+ FE AV DP ++A+ LG E A++A R L L P++
Sbjct: 348 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 407
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHF------------------------------- 282
LA + + L A +T R + P +
Sbjct: 408 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSL 467
Query: 283 --------------------PDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 322
PD C L G +A DC+ AL + P N
Sbjct: 468 FLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNK 527
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
L EEAV YR+ALE+ P + + NL G +EA+ H+ EA+ +
Sbjct: 528 LGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 585
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 46 GVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHA 105
GVL LS + D++ T A+ P ++ LG Q +EA+ YR A
Sbjct: 495 GVLFNLSGEY------DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRA 548
Query: 106 LRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
L L+P +I NL + + G AV+ ++ AL
Sbjct: 549 LELQPGYIRSRYNLGISCINLGAHREAVEHFLEAL 583
>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
sapiens]
Length = 639
Score = 64.7 bits (156), Expect = 4e-10
Identities = 63/226 (27%), Positives = 89/226 (39%), Gaps = 17/226 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++Q+P EA+ LG E Q AI R L LKPD + LA +
Sbjct: 361 AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR 420
Query: 131 GAVQAYVSALQYNPDLYCV---------RSDLGNLLKALGRLE------EAKACYLKAIE 175
A + L+Y P + + LG + LG L E K +L A+
Sbjct: 421 QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR 480
Query: 176 TQPNFAV--AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDR 233
P LG +FN GE A+ F A+++ PN + LG L +
Sbjct: 481 LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE 540
Query: 234 AVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
AVAAY RAL L P + NL G A++ + A+ +Q
Sbjct: 541 AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQ 586
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/238 (23%), Positives = 84/238 (35%), Gaps = 51/238 (21%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ A+ FE AV DP ++A+ LG E A++A R L L P++
Sbjct: 348 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 407
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHF------------------------------- 282
LA + + L A +T R + P +
Sbjct: 408 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSL 467
Query: 283 --------------------PDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 322
PD C L G +A DC+ AL + P N
Sbjct: 468 FLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNK 527
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
L EEAV YR+ALE+ P + + NL G +EA+ H+ EA+ +
Sbjct: 528 LGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 585
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 46 GVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHA 105
GVL LS + D++ T A+ P ++ LG Q +EA+ YR A
Sbjct: 495 GVLFNLSGEY------DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRA 548
Query: 106 LRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
L L+P +I NL + + G AV+ ++ AL
Sbjct: 549 LELQPGYIRSRYNLGISCINLGAHREAVEHFLEAL 583
>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
sapiens]
Length = 602
Score = 64.7 bits (156), Expect = 4e-10
Identities = 63/226 (27%), Positives = 89/226 (39%), Gaps = 17/226 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++Q+P EA+ LG E Q AI R L LKPD + LA +
Sbjct: 324 AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR 383
Query: 131 GAVQAYVSALQYNPDLYCV---------RSDLGNLLKALGRLE------EAKACYLKAIE 175
A + L+Y P + + LG + LG L E K +L A+
Sbjct: 384 QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR 443
Query: 176 TQPNFAV--AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDR 233
P LG +FN GE A+ F A+++ PN + LG L +
Sbjct: 444 LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE 503
Query: 234 AVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
AVAAY RAL L P + NL G A++ + A+ +Q
Sbjct: 504 AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQ 549
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/238 (23%), Positives = 84/238 (35%), Gaps = 51/238 (21%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ A+ FE AV DP ++A+ LG E A++A R L L P++
Sbjct: 311 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 370
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHF------------------------------- 282
LA + + L A +T R + P +
Sbjct: 371 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSL 430
Query: 283 --------------------PDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 322
PD C L G +A DC+ AL + P N
Sbjct: 431 FLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNK 490
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
L EEAV YR+ALE+ P + + NL G +EA+ H+ EA+ +
Sbjct: 491 LGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 548
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 46 GVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHA 105
GVL LS + D++ T A+ P ++ LG Q +EA+ YR A
Sbjct: 458 GVLFNLSGEY------DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRA 511
Query: 106 LRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
L L+P +I NL + + G AV+ ++ AL
Sbjct: 512 LELQPGYIRSRYNLGISCINLGAHREAVEHFLEAL 546
>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
sapiens]
Length = 654
Score = 64.7 bits (156), Expect = 4e-10
Identities = 63/226 (27%), Positives = 89/226 (39%), Gaps = 17/226 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++Q+P EA+ LG E Q AI R L LKPD + LA +
Sbjct: 376 AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR 435
Query: 131 GAVQAYVSALQYNPDLYCV---------RSDLGNLLKALGRLE------EAKACYLKAIE 175
A + L+Y P + + LG + LG L E K +L A+
Sbjct: 436 QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR 495
Query: 176 TQPNFAV--AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDR 233
P LG +FN GE A+ F A+++ PN + LG L +
Sbjct: 496 LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE 555
Query: 234 AVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
AVAAY RAL L P + NL G A++ + A+ +Q
Sbjct: 556 AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQ 601
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/238 (23%), Positives = 84/238 (35%), Gaps = 51/238 (21%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ A+ FE AV DP ++A+ LG E A++A R L L P++
Sbjct: 363 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 422
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHF------------------------------- 282
LA + + L A +T R + P +
Sbjct: 423 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSL 482
Query: 283 --------------------PDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 322
PD C L G +A DC+ AL + P N
Sbjct: 483 FLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNK 542
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
L EEAV YR+ALE+ P + + NL G +EA+ H+ EA+ +
Sbjct: 543 LGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 600
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 46 GVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHA 105
GVL LS + D++ T A+ P ++ LG Q +EA+ YR A
Sbjct: 510 GVLFNLSGEY------DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRA 563
Query: 106 LRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
L L+P +I NL + + G AV+ ++ AL
Sbjct: 564 LELQPGYIRSRYNLGISCINLGAHREAVEHFLEAL 598
>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
sapiens]
Length = 631
Score = 64.7 bits (156), Expect = 4e-10
Identities = 63/226 (27%), Positives = 89/226 (39%), Gaps = 17/226 (7%)
Query: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME 130
A++Q+P EA+ LG E Q AI R L LKPD + LA +
Sbjct: 353 AVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQR 412
Query: 131 GAVQAYVSALQYNPDLYCV---------RSDLGNLLKALGRLE------EAKACYLKAIE 175
A + L+Y P + + LG + LG L E K +L A+
Sbjct: 413 QACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVR 472
Query: 176 TQPNFAV--AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDR 233
P LG +FN GE A+ F A+++ PN + LG L +
Sbjct: 473 LDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEE 532
Query: 234 AVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
AVAAY RAL L P + NL G A++ + A+ +Q
Sbjct: 533 AVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQ 578
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/238 (23%), Positives = 84/238 (35%), Gaps = 51/238 (21%)
Query: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253
+G++ A+ FE AV DP ++A+ LG E A++A R L L P++
Sbjct: 340 EGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALM 399
Query: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHF------------------------------- 282
LA + + L A +T R + P +
Sbjct: 400 ALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSL 459
Query: 283 --------------------PDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNN 322
PD C L G +A DC+ AL + P N
Sbjct: 460 FLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNK 519
Query: 323 LANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRI 380
L EEAV YR+ALE+ P + + NL G +EA+ H+ EA+ +
Sbjct: 520 LGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNM 577
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 46 GVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHA 105
GVL LS + D++ T A+ P ++ LG Q +EA+ YR A
Sbjct: 487 GVLFNLSGEY------DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRA 540
Query: 106 LRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL 140
L L+P +I NL + + G AV+ ++ AL
Sbjct: 541 LELQPGYIRSRYNLGISCINLGAHREAVEHFLEAL 575
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 64.7 bits (156), Expect = 4e-10
Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)
Query: 255 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 314
LA VY A++ +++ ++ P C +A +E +++ A + Y L+
Sbjct: 264 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 323
Query: 315 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374
TH +++ + + E A+R YR+ L++ +NL + L +
Sbjct: 324 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 383
Query: 375 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 431
+ A+ ++ AD + N+G+ + D A QC+ A+ N A+A++NLA +
Sbjct: 384 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 443
Query: 432 SGNIPEAIASYRTALKLKPDFPDAYCNLA 460
G++ +A A +TA L P + + N A
Sbjct: 444 KGHVEQARALLQTASSLAPHMYEPHFNFA 472
Score = 64.3 bits (155), Expect = 6e-10
Identities = 58/302 (19%), Positives = 119/302 (39%), Gaps = 32/302 (10%)
Query: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
+G Y G +EA + ++ AL+ + + +D ++ LA V+ A+ + L P
Sbjct: 231 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 289
Query: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204
+ + + + + + A Y + ++ A + +G + +A+ +
Sbjct: 290 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 349
Query: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264
+ + + + NLG A+ +D + ++ RALSL+
Sbjct: 350 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLA------------------- 390
Query: 265 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 324
E + D + NL + G A C+ AL HA++ NNLA
Sbjct: 391 ------------ENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 438
Query: 325 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384
++ +G++E+A L + A + P H N A++ + G LQ + + +++ P
Sbjct: 439 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
Query: 385 AD 386
D
Sbjct: 499 VD 500
Score = 45.1 bits (105), Expect = 4e-04
Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)
Query: 42 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101
P +L ++ I+ + + +A + +KQ+ EA + +G+ + Q + A+
Sbjct: 289 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 348
Query: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 158
YR L++ + NL A + + ++ AL + + V +LG++
Sbjct: 349 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 408
Query: 159 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 218
+G A C+ A+ N A A++NL + +G + A + A +L P+ + +
Sbjct: 409 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 468
Query: 219 INLGNVLKEARIFDRAVAAYLRALSLSPNH 248
N + + R+ A ++ + P+H
Sbjct: 469 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 498
Score = 37.7 bits (86), Expect = 0.057
Identities = 40/208 (19%), Positives = 82/208 (39%), Gaps = 3/208 (1%)
Query: 12 TGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLA 71
T L +A + + +A + ++ +Q+ + + + S HF + + + F
Sbjct: 293 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL 352
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGD 128
++ + ++NLG Q + + AL L + + D + NL V GD
Sbjct: 353 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 412
Query: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
A Q + AL N + ++L L G +E+A+A A P+ N
Sbjct: 413 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFA 472
Query: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLD 216
+ + G++ + +K+ P+ +D
Sbjct: 473 TISDKIGDLQRSYVAAQKSEAAFPDHVD 500
Score = 33.1 bits (74), Expect = 1.4
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 70 LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 129
LA+ N AEAY+NL + +G +++A + A L P + + N A GD+
Sbjct: 422 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 481
Query: 130 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
+ ++YV+A Q + + D +L+K L
Sbjct: 482 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 508
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 64.7 bits (156), Expect = 4e-10
Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)
Query: 255 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 314
LA VY A++ +++ ++ P C +A +E +++ A + Y L+
Sbjct: 224 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 283
Query: 315 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374
TH +++ + + E A+R YR+ L++ +NL + L +
Sbjct: 284 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 343
Query: 375 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 431
+ A+ ++ AD + N+G+ + D A QC+ A+ N A+A++NLA +
Sbjct: 344 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 403
Query: 432 SGNIPEAIASYRTALKLKPDFPDAYCNLA 460
G++ +A A +TA L P + + N A
Sbjct: 404 KGHVEQARALLQTASSLAPHMYEPHFNFA 432
Score = 64.3 bits (155), Expect = 6e-10
Identities = 58/302 (19%), Positives = 119/302 (39%), Gaps = 32/302 (10%)
Query: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
+G Y G +EA + ++ AL+ + + +D ++ LA V+ A+ + L P
Sbjct: 191 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 249
Query: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204
+ + + + + + A Y + ++ A + +G + +A+ +
Sbjct: 250 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 309
Query: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264
+ + + + NLG A+ +D + ++ RALSL+
Sbjct: 310 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLA------------------- 350
Query: 265 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 324
E + D + NL + G A C+ AL HA++ NNLA
Sbjct: 351 ------------ENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 398
Query: 325 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384
++ +G++E+A L + A + P H N A++ + G LQ + + +++ P
Sbjct: 399 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 458
Query: 385 AD 386
D
Sbjct: 459 VD 460
Score = 45.1 bits (105), Expect = 4e-04
Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)
Query: 42 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101
P +L ++ I+ + + +A + +KQ+ EA + +G+ + Q + A+
Sbjct: 249 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 308
Query: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 158
YR L++ + NL A + + ++ AL + + V +LG++
Sbjct: 309 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 368
Query: 159 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 218
+G A C+ A+ N A A++NL + +G + A + A +L P+ + +
Sbjct: 369 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 428
Query: 219 INLGNVLKEARIFDRAVAAYLRALSLSPNH 248
N + + R+ A ++ + P+H
Sbjct: 429 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 458
Score = 37.7 bits (86), Expect = 0.057
Identities = 40/208 (19%), Positives = 82/208 (39%), Gaps = 3/208 (1%)
Query: 12 TGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLA 71
T L +A + + +A + ++ +Q+ + + + S HF + + + F
Sbjct: 253 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL 312
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGD 128
++ + ++NLG Q + + AL L + + D + NL V GD
Sbjct: 313 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 372
Query: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
A Q + AL N + ++L L G +E+A+A A P+ N
Sbjct: 373 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFA 432
Query: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLD 216
+ + G++ + +K+ P+ +D
Sbjct: 433 TISDKIGDLQRSYVAAQKSEAAFPDHVD 460
Score = 33.1 bits (74), Expect = 1.4
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 70 LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 129
LA+ N AEAY+NL + +G +++A + A L P + + N A GD+
Sbjct: 382 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 441
Query: 130 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
+ ++YV+A Q + + D +L+K L
Sbjct: 442 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 468
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 64.7 bits (156), Expect = 4e-10
Identities = 48/209 (22%), Positives = 94/209 (44%), Gaps = 3/209 (1%)
Query: 255 LACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCP 314
LA VY A++ +++ ++ P C +A +E +++ A + Y L+
Sbjct: 254 LAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDN 313
Query: 315 THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374
TH +++ + + E A+R YR+ L++ +NL + L +
Sbjct: 314 THVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSF 373
Query: 375 KEAIRISPT---FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKD 431
+ A+ ++ AD + N+G+ + D A QC+ A+ N A+A++NLA +
Sbjct: 374 ERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMR 433
Query: 432 SGNIPEAIASYRTALKLKPDFPDAYCNLA 460
G++ +A A +TA L P + + N A
Sbjct: 434 KGHVEQARALLQTASSLAPHMYEPHFNFA 462
Score = 64.3 bits (155), Expect = 6e-10
Identities = 58/302 (19%), Positives = 119/302 (39%), Gaps = 32/302 (10%)
Query: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
+G Y G +EA + ++ AL+ + + +D ++ LA V+ A+ + L P
Sbjct: 221 IGKCYYRLGMYREAEKQFKSALK-QQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFP 279
Query: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204
+ + + + + + A Y + ++ A + +G + +A+ +
Sbjct: 280 GEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFY 339
Query: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264
+ + + + NLG A+ +D + ++ RALSL+
Sbjct: 340 RRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLA------------------- 380
Query: 265 IDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLA 324
E + D + NL + G A C+ AL HA++ NNLA
Sbjct: 381 ------------ENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLA 428
Query: 325 NIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTF 384
++ +G++E+A L + A + P H N A++ + G LQ + + +++ P
Sbjct: 429 VLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
Query: 385 AD 386
D
Sbjct: 489 VD 490
Score = 45.1 bits (105), Expect = 4e-04
Identities = 41/210 (19%), Positives = 89/210 (42%), Gaps = 3/210 (1%)
Query: 42 PDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH 101
P +L ++ I+ + + +A + +KQ+ EA + +G+ + Q + A+
Sbjct: 279 PGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRF 338
Query: 102 YRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSAL---QYNPDLYCVRSDLGNLLK 158
YR L++ + NL A + + ++ AL + + V +LG++
Sbjct: 339 YRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAV 398
Query: 159 ALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY 218
+G A C+ A+ N A A++NL + +G + A + A +L P+ + +
Sbjct: 399 GIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPH 458
Query: 219 INLGNVLKEARIFDRAVAAYLRALSLSPNH 248
N + + R+ A ++ + P+H
Sbjct: 459 FNFATISDKIGDLQRSYVAAQKSEAAFPDH 488
Score = 37.7 bits (86), Expect = 0.057
Identities = 40/208 (19%), Positives = 82/208 (39%), Gaps = 3/208 (1%)
Query: 12 TGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLA 71
T L +A + + +A + ++ +Q+ + + + S HF + + + F
Sbjct: 283 TLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRL 342
Query: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL---KPDFIDGYINLAAALVAAGD 128
++ + ++NLG Q + + AL L + + D + NL V GD
Sbjct: 343 LQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGD 402
Query: 129 MEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLG 188
A Q + AL N + ++L L G +E+A+A A P+ N
Sbjct: 403 TNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFA 462
Query: 189 CVFNAQGEIWLAIHHFEKAVTLDPNFLD 216
+ + G++ + +K+ P+ +D
Sbjct: 463 TISDKIGDLQRSYVAAQKSEAAFPDHVD 490
Score = 33.1 bits (74), Expect = 1.4
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 70 LAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDM 129
LA+ N AEAY+NL + +G +++A + A L P + + N A GD+
Sbjct: 412 LALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDL 471
Query: 130 EGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
+ ++YV+A Q + + D +L+K L
Sbjct: 472 Q---RSYVAA-QKSEAAFPDHVDTQHLIKQL 498
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,624,582
Number of Sequences: 37866
Number of extensions: 1709135
Number of successful extensions: 5388
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 112
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 3752
Number of HSP's gapped (non-prelim): 961
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.