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Search of human proteins with 32189362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
(1194 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens] 2342 0.0
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 1378 0.0
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 1356 0.0
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens] 1345 0.0
gi|55769554 protein tyrosine phosphatase, receptor type, f polyp... 731 0.0
gi|157837985 kazrin isoform E [Homo sapiens] 186 1e-46
gi|170784854 PTPRF interacting protein, binding protein 2 (lipri... 148 3e-35
gi|29294627 PTPRF interacting protein binding protein 1 isoform ... 143 1e-33
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 101 5e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 100 8e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 100 1e-20
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 99 2e-20
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 99 2e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 97 9e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 97 9e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 97 9e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 97 9e-20
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 97 1e-19
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 96 2e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 96 3e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 94 1e-18
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 93 2e-18
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 92 3e-18
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 92 4e-18
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 92 4e-18
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 92 4e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 91 5e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 91 9e-18
gi|16262452 cingulin [Homo sapiens] 89 2e-17
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 89 2e-17
>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
Length = 1194
Score = 2342 bits (6069), Expect = 0.0
Identities = 1194/1194 (100%), Positives = 1194/1194 (100%)
Query: 1 MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRL 60
MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRL
Sbjct: 1 MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRL 60
Query: 61 RELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHL 120
RELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHL
Sbjct: 61 RELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHL 120
Query: 121 ECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALER 180
ECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALER
Sbjct: 121 ECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALER 180
Query: 181 VAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE 240
VAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE
Sbjct: 181 VAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE 240
Query: 241 ALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED 300
ALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED
Sbjct: 241 ALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED 300
Query: 301 MEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQK 360
MEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQK
Sbjct: 301 MEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQK 360
Query: 361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRE 420
LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRE
Sbjct: 361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRE 420
Query: 421 KMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNK 480
KMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNK
Sbjct: 421 KMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNK 480
Query: 481 EQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRA 540
EQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRA
Sbjct: 481 EQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRA 540
Query: 541 GKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQ 600
GKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQ
Sbjct: 541 GKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQ 600
Query: 601 TLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLT 660
TLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLT
Sbjct: 601 TLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLT 660
Query: 661 TSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPR 720
TSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPR
Sbjct: 661 TSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPR 720
Query: 721 SARLERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMG 780
SARLERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMG
Sbjct: 721 SARLERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMG 780
Query: 781 PPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDG 840
PPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDG
Sbjct: 781 PPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDG 840
Query: 841 PTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQE 900
PTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQE
Sbjct: 841 PTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQE 900
Query: 901 MVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGND 960
MVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGND
Sbjct: 901 MVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGND 960
Query: 961 WLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYD 1020
WLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYD
Sbjct: 961 WLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYD 1020
Query: 1021 RKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDY 1080
RKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDY
Sbjct: 1021 RKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDY 1080
Query: 1081 SDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLR 1140
SDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLR
Sbjct: 1081 SDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLR 1140
Query: 1141 GVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC 1194
GVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC
Sbjct: 1141 GVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC 1194
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sapiens]
Length = 1202
Score = 1378 bits (3566), Expect = 0.0
Identities = 757/1244 (60%), Positives = 920/1244 (73%), Gaps = 92/1244 (7%)
Query: 1 MMCEVMPTISE--------DGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDG 52
MMCEVMPTISE G + +A E+LMV+ML ER+RLL+TLRE Q+
Sbjct: 1 MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
Query: 53 LATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN 112
LA Q +L E+GHE+DSLQRQL+ ALPQEFAALTKELN+CREQLLEREEEIAELKAERNN
Sbjct: 61 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120
Query: 113 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRE 172
TRLLLEHLECLVSRHERSLRMTVVKRQAQSP GVSSEVEVLKALKSLFEHHKALDEKVRE
Sbjct: 121 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
Query: 173 RLRMALERVAVLEEELELSNQETLNLREQLSRRRS---GL------EEPGKDGDGQTLAN 223
RLR+ALER ++LEEEL +++E + L+EQ +++++ G+ +E G+ ++
Sbjct: 181 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
Query: 224 GLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEA 283
G + + EL+E + +Q E Q++ERLA L +++LEE+L TA ++L K+EE
Sbjct: 241 GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
Query: 284 NSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQS 343
N+KLQRD++EA+AQ+EDMEERITTLEKRYL+AQREATS+HD NDKLENE+A+K+S++RQ+
Sbjct: 301 NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
Query: 344 EEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE 403
E+K+RQL E L+ A+QKLQQTL+KAETLPE+EA+LAQRVAAL+KAEERHGN EERLRQ+E
Sbjct: 361 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420
Query: 404 AQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLS 463
AQLEEKNQELQRARQREKMN++HNKRLS+TVDKLLSESNERLQLHLKERM ALE+KNSL
Sbjct: 421 AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480
Query: 464 EEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPS-SYSRSLPGSALELRYSQAP 522
E+ + KK +E +K+QL+ +E ++ E+D +R R S + R GS + R+ A
Sbjct: 481 REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA- 539
Query: 523 TLPSGAHLDPYVAGSG-RAGKRGRWSGVKEEPSK-------DWERSAPA---GSIPPPFP 571
H D Y + R ++GR + +++EPSK DWER+ A ++ F
Sbjct: 540 ----DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFE 595
Query: 572 GELDGSDEEEAEG--MFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQ 629
+ D SD E+ + +LLSPSGQAD TLA+MLQEQL+AINKEI+LIQEEKE TEQ
Sbjct: 596 SDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQ 655
Query: 630 RAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPARE-- 687
RAEE+ESRV S LD+LGR+RS S+PP S+LAS SPP SG STPR P SPARE
Sbjct: 656 RAEEIESRVGSGSLDNLGRFRSMSSIPP-YPASSLASSSPPGSGRSTPRRIPHSPAREVD 714
Query: 688 --GTDKANHVPKEEAGAPRGEGPAIPGDT-PPPTPRSARLERMTQALALQAGSLED---- 740
G +EE R + I +T PP +PR+ RL+R+ + AL S ED
Sbjct: 715 RLGVMTLLPPSREEV---RDDKTTIKCETSPPSSPRALRLDRLHKG-ALHTVSHEDIRDI 770
Query: 741 -------GGP---PRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLA 790
GP P S + DSLHKAPKKK IKSSIGRLFGKKEKGR G G+++ A
Sbjct: 771 RNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQA 830
Query: 791 GTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELW 850
G + + D LGL+KL G +K+R+ ++KHELLEEA RQGLPFA WDGPTVV WLELW
Sbjct: 831 GVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELW 890
Query: 851 VGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAP 910
VGMPAWYVAACRANVKSGAIM+ LSDTEIQREIGISNPLHRLKLRLAIQE++SLTSPSAP
Sbjct: 891 VGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAP 950
Query: 911 ASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQY 970
+SRT+ LAYGDMNHEW+GN+WLPSLGLPQY
Sbjct: 951 PTSRTT------------------------------LAYGDMNHEWIGNEWLPSLGLPQY 980
Query: 971 RSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREE 1030
RSYFME LVDARMLDHL KK+LRGQLKMVDSFHR S GIMCL+RLNYDRK+LER+REE
Sbjct: 981 RSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREE 1040
Query: 1031 SQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIP 1090
SQ++I+DV+VWSN+RV+ W+ +GLKE+A NL ESGVHGALLALDETFD+S LALLLQIP
Sbjct: 1041 SQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIP 1100
Query: 1091 TQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEML 1150
TQN QAR +LE+EF+NL+ +GTDRR DED KSF R+PSWRK FR KD+RG+ SAE L
Sbjct: 1101 TQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETL 1160
Query: 1151 PPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC 1194
P NFR ++ SP + +K+Q +G SG+ R D +VRTYSC
Sbjct: 1161 PANFR--VTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTYSC 1202
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 1356 bits (3510), Expect = 0.0
Identities = 747/1226 (60%), Positives = 908/1226 (74%), Gaps = 92/1226 (7%)
Query: 1 MMCEVMPTISE--------DGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDG 52
MMCEVMPTISE G + +A E+LMV+ML ER+RLL+TLRE Q+
Sbjct: 1 MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
Query: 53 LATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN 112
LA Q +L E+GHE+DSLQRQL+ ALPQEFAALTKELN+CREQLLEREEEIAELKAERNN
Sbjct: 61 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120
Query: 113 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRE 172
TRLLLEHLECLVSRHERSLRMTVVKRQAQSP GVSSEVEVLKALKSLFEHHKALDEKVRE
Sbjct: 121 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
Query: 173 RLRMALERVAVLEEELELSNQETLNLREQLSRRRS---GL------EEPGKDGDGQTLAN 223
RLR+ALER ++LEEEL +++E + L+EQ +++++ G+ +E G+ ++
Sbjct: 181 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
Query: 224 GLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEA 283
G + + EL+E + +Q E Q++ERLA L +++LEE+L TA ++L K+EE
Sbjct: 241 GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
Query: 284 NSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQS 343
N+KLQRD++EA+AQ+EDMEERITTLEKRYL+AQREATS+HD NDKLENE+A+K+S++RQ+
Sbjct: 301 NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
Query: 344 EEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE 403
E+K+RQL E L+ A+QKLQQTL+KAETLPE+EA+LAQRVAAL+KAEERHGN EERLRQ+E
Sbjct: 361 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420
Query: 404 AQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLS 463
AQLEEKNQELQRARQREKMN++HNKRLS+TVDKLLSESNERLQLHLKERM ALE+KNSL
Sbjct: 421 AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480
Query: 464 EEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPS-SYSRSLPGSALELRYSQAP 522
E+ + KK +E +K+QL+ +E ++ E+D +R R S + R GS + R+ A
Sbjct: 481 REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA- 539
Query: 523 TLPSGAHLDPYVAGSG-RAGKRGRWSGVKEEPSK-------DWERSAPA---GSIPPPFP 571
H D Y + R ++GR + +++EPSK DWER+ A ++ F
Sbjct: 540 ----DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFE 595
Query: 572 GELDGSDEEEAEG--MFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQ 629
+ D SD E+ + +LLSPSGQAD TLA+MLQEQL+AINKEI+LIQEEKE TEQ
Sbjct: 596 SDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQ 655
Query: 630 RAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPARE-- 687
RAEE+ESRV S LD+LGR+RS S+PP S+LAS SPP SG STPR P SPARE
Sbjct: 656 RAEEIESRVGSGSLDNLGRFRSMSSIPP-YPASSLASSSPPGSGRSTPRRIPHSPAREVD 714
Query: 688 --GTDKANHVPKEEAGAPRGEGPAIPGDT-PPPTPRSARLERMTQALALQAGSLED---- 740
G +EE R + I +T PP +PR+ RL+R+ + AL S ED
Sbjct: 715 RLGVMTLLPPSREEV---RDDKTTIKCETSPPSSPRALRLDRLHKG-ALHTVSHEDIRDI 770
Query: 741 -------GGP---PRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLA 790
GP P S + DSLHKAPKKK IKSSIGRLFGKKEKGR G G+++ A
Sbjct: 771 RNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQA 830
Query: 791 GTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELW 850
G + + D LGL+KL G +K+R+ ++KHELLEEA RQGLPFA WDGPTVV WLELW
Sbjct: 831 GVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELW 890
Query: 851 VGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAP 910
VGMPAWYVAACRANVKSGAIM+ LSDTEIQREIGISNPLHRLKLRLAIQE++SLTSPSAP
Sbjct: 891 VGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAP 950
Query: 911 ASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQY 970
+SRT+ LAYGDMNHEW+GN+WLPSLGLPQY
Sbjct: 951 PTSRTT------------------------------LAYGDMNHEWIGNEWLPSLGLPQY 980
Query: 971 RSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREE 1030
RSYFME LVDARMLDHL KK+LRGQLKMVDSFHR S GIMCL+RLNYDRK+LER+REE
Sbjct: 981 RSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREE 1040
Query: 1031 SQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIP 1090
SQ++I+DV+VWSN+RV+ W+ +GLKE+A NL ESGVHGALLALDETFD+S LALLLQIP
Sbjct: 1041 SQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIP 1100
Query: 1091 TQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEML 1150
TQN QAR +LE+EF+NL+ +GTDRR DED KSF R+PSWRK FR KD+RG+ SAE L
Sbjct: 1101 TQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETL 1160
Query: 1151 PPNFRSAAAGALGSPGLPLRKLQPEG 1176
P NFR ++ SP + +K+Q +G
Sbjct: 1161 PANFR--VTSSMSSPSMQPKKMQMDG 1184
>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
Length = 1257
Score = 1345 bits (3480), Expect = 0.0
Identities = 753/1279 (58%), Positives = 924/1279 (72%), Gaps = 107/1279 (8%)
Query: 1 MMCEVMPTISED---GRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQ 57
MMCEVMPTI+ED +RGS ++ E+LMV ML ER+RLL+TLRE Q+ L+ AQ
Sbjct: 1 MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ 60
Query: 58 LRLRELGHEKDSLQRQLSIALPQ------------------EFAALTKELNLCREQLLER 99
RL+++ +++DSLQRQL+ ALPQ EFAALTKELN CREQLLE+
Sbjct: 61 QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK 120
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
EEEI+ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP GVSSEVEVLKALKSL
Sbjct: 121 EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL 180
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLE------ 210
FEHHKALDEKVRERLR++LERV+ LEEEL +NQE + LREQ + R+ + E
Sbjct: 181 FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE 240
Query: 211 -----EPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQ 265
EPG+ + L+NG D + EL+E LE+Q E+ Q++ERLA L ++ +
Sbjct: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
Query: 266 LEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDA 325
+E+E TA ++L K EE N+K QRD++EA+AQ+EDMEERITTLEKRYLSAQRE+TS+HD
Sbjct: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM 360
Query: 326 NDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAAL 385
NDKLENELA+KE++ RQ EEK+RQL E L+ A+QKLQQT++KAETLPE+EA+LAQR+AAL
Sbjct: 361 NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL 420
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
KAEERHGN EER+R LE QLEEKNQELQRARQREKMN++HNKRLS+TVD+LL+ESNERL
Sbjct: 421 TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL 480
Query: 446 QLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSY 505
QLHLKERM ALEEKN L +E +K +E L +KE+L E+E+++ E+DQL+ R S
Sbjct: 481 QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI 540
Query: 506 SRSLPGSAL----ELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEP------SK 555
++P + L ELRYS + S + D R +RGR ++EP
Sbjct: 541 EPTIPRTHLDTSAELRYSVGSLVDSQS--DYRTTKVIRRPRRGRMGVRRDEPKVKSLGDH 598
Query: 556 DWERSAPAGSIPP-PFPG--ELDGSDEEEAEGMFGA-ELLSPSGQADVQTLAIMLQEQLE 611
+W R+ G + PF E+ D+++ E +F + +LLSPSG +D QTLA+MLQEQL+
Sbjct: 599 EWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLD 658
Query: 612 AINKEIKLIQEEKETTEQRAEELESRVSSSGLD--SLGRYRSSCSLPPSLTTSTLASPSP 669
AINKEI+LIQEEKE+TE RAEE+E+RV+S L+ +L R S+ S+T S+LAS SP
Sbjct: 659 AINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSP 718
Query: 670 PSSGHSTPRLAPPSPARE---------GTDKANHVPK----EEAGAPRGEGPAIPGDT-P 715
P SGHSTP+L P SPARE +D H K EE G R + I +T P
Sbjct: 719 P-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDG--REDKATIKCETSP 775
Query: 716 PPTPRSARL-----------ERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIK 764
PPTPR+ R+ R + +++L+ SL G + + DSLHKAPKKK IK
Sbjct: 776 PPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLG----SANSSQDSLHKAPKKKGIK 831
Query: 765 SSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHEL 824
SSIGRLFGKKEK R+G L G E A + LGL KL +KDRR K+KHEL
Sbjct: 832 SSIGRLFGKKEKARLG-------QLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHEL 884
Query: 825 LEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIG 884
LEEA R+GLPFA WDGPTVV+WLELW+GMPAWYVAACRANVKSGAIM+ LSDTEIQREIG
Sbjct: 885 LEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIG 944
Query: 885 ISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTK-PETKEISW 943
ISNPLHRLKLRLAIQEMVSLTSPSAP +SRT +GNVW+THEEME+L A K E++E SW
Sbjct: 945 ISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSW 1004
Query: 944 E------QILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLK 997
Q LAYGDMNHEW+GN+WLPSLGLPQYRSYFME LVDARMLDHL KK+LR LK
Sbjct: 1005 AQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLK 1064
Query: 998 MVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKE 1057
MVDSFHR SL YGIMCLKRLNYDRK+LERRRE SQ +I+DV+VWSN+RV+ W+ +GL+E
Sbjct: 1065 MVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLRE 1124
Query: 1058 FATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLD 1117
+A N+ ESGVHG+L+ALDE FDYS LALLLQIPTQN QARQ+LE+E++NL++LGT+RRLD
Sbjct: 1125 YANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLD 1184
Query: 1118 EDSAKSFSRSPSWRKMFREKDLRGVT--PDSAEMLPPNFRSAAAGALGSPGLPLRKLQPE 1175
E K+F R +WR+ F +++ G++ P S+E LP FR RK+ +
Sbjct: 1185 ESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQS------RKMTTD 1238
Query: 1176 GQTSGSSRADGVSVRTYSC 1194
+S R D +VRTYSC
Sbjct: 1239 VASSRLQRLDNSTVRTYSC 1257
>gi|55769554 protein tyrosine phosphatase, receptor type, f
polypeptide (PTPRF), interacting protein (liprin), alpha
4 [Homo sapiens]
Length = 701
Score = 731 bits (1888), Expect = 0.0
Identities = 399/699 (57%), Positives = 500/699 (71%), Gaps = 43/699 (6%)
Query: 511 GSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPF 570
GSA ++R+S T H P G R+S ++EE +KDWE S G + P
Sbjct: 2 GSAADVRFSLGTT----THAPP--------GVHRRYSALREESAKDWETSPLPGMLAPAA 49
Query: 571 PGELDGS------DEEEAEGMFG-AELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEE 623
D DE+E G+ G A+++SPSG +D QTLA+MLQEQL+AIN+EI++IQEE
Sbjct: 50 GPAFDSDPEISDVDEDEPGGLVGSADVVSPSGHSDAQTLAMMLQEQLDAINEEIRMIQEE 109
Query: 624 KETTEQRAEELESRVSSSGLDSLG--RYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAP 681
KE+TE RAEE+E+RV+S +++L + R S+P SLT +LAS SPP SG STP+L
Sbjct: 110 KESTELRAEEIETRVTSGSMEALNLKQLRKRGSIPTSLTALSLASASPPLSGRSTPKLTS 169
Query: 682 PSPARE---------GTDKANHVPKEEAGAPRGEG----PAIPGDTPPPT-PRSARLERM 727
S A++ +D H K + R E I +T PP+ PR+ RLE++
Sbjct: 170 RSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLRLEKL 229
Query: 728 TQ-ALALQAG--SLED-GGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPG 783
AL+ + G +LED G P S + DSLHK K+K IKSSIGRLFGKKEKGR+
Sbjct: 230 GHPALSQEEGKSALEDQGSNPSSSNSSQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLS 289
Query: 784 RDSSSLAGTPSDETLAT-DPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPT 842
RD ++ +D + +P+ AKL +KDRR K+KH+LLE+A R+G+PFA WDGPT
Sbjct: 290 RDGATGHVLLTDSEFSMQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPT 349
Query: 843 VVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMV 902
VVSWLELWVGMPAWYVAACRANVKSGAIM+ LSDTEIQREIGISN LHRLKLRLAIQEMV
Sbjct: 350 VVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMV 409
Query: 903 SLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWL 962
SLTSPSAP +SRTS+GNVW+THEEME+L +TK +++E SW Q LAYGDMNHEW+GN+WL
Sbjct: 410 SLTSPSAPPTSRTSSGNVWVTHEEMETLETSTKTDSEEGSWAQTLAYGDMNHEWIGNEWL 469
Query: 963 PSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRK 1022
PSLGLPQYRSYFME LVDARMLDHL KK+LR LKMVDSFHR SL YGIMCLKRLNYDRK
Sbjct: 470 PSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRK 529
Query: 1023 DLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSD 1082
+LE+RREESQ +I+DV+VW+N++V+ WV +GL+++A NL ESGVHGALLALDE FD++
Sbjct: 530 ELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNT 589
Query: 1083 LALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLR-- 1140
LAL+LQIPTQN QARQ++E+EF+NL++LGTDR+LD+ K F R+PSWRK FR ++
Sbjct: 590 LALILQIPTQNTQARQVMEREFNNLLALGTDRKLDDGDDKVFRRAPSWRKRFRPREHHGR 649
Query: 1141 -GVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQT 1178
G+ SAE LP FR + G L P P +K+ PE +
Sbjct: 650 GGMLSASAETLPAGFRVSTLGTLQPPPAPPKKIMPEAHS 688
>gi|157837985 kazrin isoform E [Homo sapiens]
Length = 775
Score = 186 bits (471), Expect = 1e-46
Identities = 131/415 (31%), Positives = 200/415 (48%), Gaps = 68/415 (16%)
Query: 699 EAGAPRGEGPAIPGDTPPPTPRSARLERMTQALALQAG-------SLEDGGPPRGSEGTP 751
+A A G+ + P D P R+ L +Q SLED
Sbjct: 322 DASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHNPIVQSLED---------LE 372
Query: 752 DSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGR-DSSSLAGTPSDETLATDPLGLAKLTG 810
D K K+K SI R+F + ++ + PG D S +P+ ++L+
Sbjct: 373 DQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSE-------- 424
Query: 811 PGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAI 870
G++ ++ EL+ P + W TV +WLE+ + MP YV AC NVKSG +
Sbjct: 425 -GEEQMDRLQQVELVRTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKV 477
Query: 871 MANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESL 930
+ +LSD ++Q +G+ + LHR KLRLAI++ + + E+
Sbjct: 478 LLSLSDEDLQLGLGVCSSLHRRKLRLAIED-----------------------YRDAEAG 514
Query: 931 TATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKK 990
+ +K +++H WV WL +GL QY F LVD RML+ L K+
Sbjct: 515 RSLSKA-------------AELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKR 561
Query: 991 ELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWV 1050
+L L + FH+VS+ GI L ++N+ R+ L+ RR +TQ D +VW+N+RV+ WV
Sbjct: 562 DLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWV 621
Query: 1051 SGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFS 1105
+ LKE+A NLT SGVHGA+L L+ TF+ +A L IP+ R+ L +E S
Sbjct: 622 RDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMS 676
Score = 31.2 bits (69), Expect = 6.2
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
++++L T+ + E+L + +R + ++ ++ L EKD L+R+ L ++ T
Sbjct: 158 QMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLERE-KWELRRQAKEAT 216
Query: 87 KELNLCREQLLEREEEIAELKAE 109
R QL ++ + EL+AE
Sbjct: 217 DHATALRSQLDLKDNRMKELEAE 239
>gi|170784854 PTPRF interacting protein, binding protein 2 (liprin
beta 2) [Homo sapiens]
Length = 876
Score = 148 bits (374), Expect = 3e-35
Identities = 193/784 (24%), Positives = 311/784 (39%), Gaps = 103/784 (13%)
Query: 369 ETLPEIEAQLAQRVAALNKA-EER----HGNFEERLRQLEAQLEEKNQELQRARQREKMN 423
E E +Q+ AA N+ +ER G+ E + Q+ ++ + ++ R E
Sbjct: 87 EWFEESLSQVNHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCL 146
Query: 424 DDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQ---DELLLNK 480
+ H +L+ + L E R L +++ + E + L ++ M+K Q +E
Sbjct: 147 EGHQVKLNAAEEMLQQELLSRTSLET-QKLDLMTEVSELKLKLVGMEKEQREQEEKQRKA 205
Query: 481 EQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRA 540
E+LL E+ +++++++L + Y L + E+ Q A ++ + R
Sbjct: 206 EELLQELRHLKIKVEELENER-NQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRT 264
Query: 541 GKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGA-----ELLSPSG 595
S E ++ +R G E EE G+ E++ +
Sbjct: 265 A--ALHSESHTERDQEIQR-LKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQ 321
Query: 596 QADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSS----------SGLDS 645
+TL+I +E +K ++ +E +Q E+ R SS L++
Sbjct: 322 GPSERTLSINEEEPEGGFSKWNATNKDPEELFKQ---EMPPRCSSPTVGPPPLPQKSLET 378
Query: 646 LGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGA-PR 704
+ + SCSL + S P L P K +P + +GA P
Sbjct: 379 RAQKKLSCSLEDLRSESV---DKCMDGNQPFPVLEPKDSPFLAEHKYPTLPGKLSGATPN 435
Query: 705 GEGPAIPGDTPPPTPRSARLERM--TQALALQAGSLED-GGPPRGSEGTPDSLHKAPKKK 761
GE P P + L R+ T++ + D G+E P S P K
Sbjct: 436 GEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQS-PLTPDGK 494
Query: 762 SIKSSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDR---RN 818
I + +GK + + G TD LG+A+ G + R
Sbjct: 495 RNPKGIKKFWGKIRRTQSG----------------NFYTDTLGMAEFRRGGLRATAGPRL 538
Query: 819 KRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTE 878
R + + PFA W V +WLE + G+ A YV R V SG + + +
Sbjct: 539 SRTRDSKGQKSDANAPFAQWSTERVCAWLEDF-GL-AQYVIFARQWVSSGHTLLTATPQD 596
Query: 879 IQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPET 938
+++E+GI +PLHR KL LA++ + TK E
Sbjct: 597 MEKELGIKHPLHRKKLVLAVKAI-------------------------------NTKQEE 625
Query: 939 KEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKM 998
K ++H WV WL +GLPQY+ F ES VD RML +L +L LK+
Sbjct: 626 KSAL---------LDHIWVTR-WLDDIGLPQYKDQFHESRVDGRMLQYLTVNDLLF-LKV 674
Query: 999 VDSFHRVSLHYGIMCLKRLNYDRKDLERR-REESQTQIRDVMVWSNERVMGWVSGLGLKE 1057
H +S+ I L ++ L RR +ES +V+ WSN RVM W+ + L E
Sbjct: 675 TSQLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAE 734
Query: 1058 FATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLD 1117
+A NL SGVHG L+ L+ F LA+LL IP Q R+ L +F+ LI ++
Sbjct: 735 YAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKR 794
Query: 1118 EDSA 1121
E A
Sbjct: 795 EKMA 798
Score = 39.3 bits (90), Expect = 0.023
Identities = 55/237 (23%), Positives = 101/237 (42%), Gaps = 22/237 (9%)
Query: 232 NRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDL 291
N +A E + + A + +E L + ++ E G R+L E + +++ +
Sbjct: 97 NHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGH-QVKLNA 155
Query: 292 KEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLA 351
E + Q+E + T+LE + L E + +L+ +L E R+ EEK R+
Sbjct: 156 AEEMLQQELLSR--TSLETQKLDLMTEVS-------ELKLKLVGMEKEQREQEEKQRKAE 206
Query: 352 EWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
E L Q+L+ K E L Q ++ A KAE +E++ +A++E +
Sbjct: 207 ELL----QELRHLKIKVEELENERNQYEWKLKA-TKAEV--AQLQEQVALKDAEIERLHS 259
Query: 412 ELQRA----RQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSE 464
+L R + D +RL ++ LL +NE ++E G L + + E
Sbjct: 260 QLSRTAALHSESHTERDQEIQRLKMGMETLLL-ANEDKDRRIEELTGLLNQYRKVKE 315
Score = 39.3 bits (90), Expect = 0.023
Identities = 57/208 (27%), Positives = 91/208 (43%), Gaps = 18/208 (8%)
Query: 55 TAQLRLRELGHEKDSLQRQLSIALPQEFAALTK--ELNLCRE----QLLEREEEIAELKA 108
T Q RL L +K+SL Q+S+ Q A K +L +C E +L EE + +
Sbjct: 106 TYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELL 165
Query: 109 ERNNTRLLLEHLECLVSRHERSLRMT-VVKRQAQSPGGVSSEVEVLKALKSLFEHHKALD 167
R T L + L+ + E L++ + K Q + E+L+ L+ L + L+
Sbjct: 166 SR--TSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELE 223
Query: 168 EKVRE---RLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEE--PGKDGDGQTLA 222
+ + +L+ VA L+E++ L + E L QLSR + E +D + Q L
Sbjct: 224 NERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLK 283
Query: 223 NG----LGPGGDSNRRTAELEEALERQR 246
G L D +RR EL L + R
Sbjct: 284 MGMETLLLANEDKDRRIEELTGLLNQYR 311
>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
[Homo sapiens]
Length = 1005
Score = 143 bits (360), Expect = 1e-33
Identities = 201/857 (23%), Positives = 338/857 (39%), Gaps = 146/857 (17%)
Query: 282 EANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYR 341
EA + RDL+ L E+ E++ E+ TSL L E+++ + L
Sbjct: 128 EAQGEKIRDLEFCL---EEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLK-LKL 183
Query: 342 QSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQ 401
+ EK R D + K + T + + ++ ++++ + + E++ + ++ L
Sbjct: 184 TAVEKDRL------DYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKDELAS 237
Query: 402 LEAQLEEKNQELQRARQRE--KMNDDHNKRLS--ETVDKLLSESN---ERLQLHLKERMG 454
L+ QLEEK E++R +++ KM + + + E K L E N ++++ ++ M
Sbjct: 238 LKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDENFKKKLKEKNIEVQKMKKAVESLMA 297
Query: 455 ALEEKNSLSEEIANM----KKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLP 510
A EEK+ E++ KK+QD ++L + + + E ++ L SS +
Sbjct: 298 ANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEEL----LNSSSISSLLDAQG 353
Query: 511 GSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPF 570
S LE S P + S + DP+ + V EE + + SIP
Sbjct: 354 FSDLEKSPSPTPVMGSPS-CDPFN------------TSVPEE----FHTTILQVSIPSLL 396
Query: 571 PGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQR 630
P + E+++ L+P + + + +I T+
Sbjct: 397 PATVSMETSEKSK-------LTPKPETSFE-------------ENDGNIILGATVDTQLC 436
Query: 631 AEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTD 690
+ L S + S SLG + S T + P+ L P P ++ +
Sbjct: 437 DKLLTSSLQKSS--SLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSM 494
Query: 691 KANHVPKEEAGAPRGEG-------------PAIPGDTPPPTPRSARLERMTQALALQAGS 737
N + + G G P + P A E+ T AG+
Sbjct: 495 DDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLDRKRSASAPTLAETEKETAEHLDLAGA 554
Query: 738 LEDGGPPRGSEGTPDSLHKAPKKKSIKSSIG--RLFGKKEKGRMGPPGRDSSSLAGTPSD 795
P+ S+ P S K S G +LFGK + + D S
Sbjct: 555 ---SSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRG 611
Query: 796 ETLAT--DPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWL-ELWVG 852
T AT LG ++ G + D +PFA W V +WL E +G
Sbjct: 612 GTRATAGPRLGWSRDLGQSNSDL---------------DMPFAKWTKEQVCNWLMEQGLG 656
Query: 853 MPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPAS 912
Y+ + + + SG + S ++++E+GI + LHR KL+LA+Q + S
Sbjct: 657 S---YLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGS--------- 704
Query: 913 SRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRS 972
E+ +G ++ WV WL +GLPQY++
Sbjct: 705 -------------------------------EEETNHGKLDFNWVTR-WLDDIGLPQYKT 732
Query: 973 YFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQ 1032
F E VD RML ++ +L LK+V H +S+ I L+ N++ L RR +
Sbjct: 733 QFDEGRVDGRMLHYMTVDDLLS-LKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDEN 791
Query: 1033 TQI-RDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPT 1091
T +V W+N RVM W+ + L E+A NL SGVHG L+ L+ F+ +A LL IP
Sbjct: 792 TIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPP 851
Query: 1092 QNAQARQLLEKEFSNLI 1108
R+ L F+ LI
Sbjct: 852 NKTLLRRHLATHFNLLI 868
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/210 (19%), Positives = 93/210 (44%), Gaps = 22/210 (10%)
Query: 239 EEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQR 298
EE L+++ L + L ++S L+ +L ++ E+ RD + + +
Sbjct: 152 EEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKF----RDTEGLIQEI 207
Query: 299 EDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEK--------SRQL 350
D+ +++ ++ L +++ S D L+ +L KES ++ +EK ++
Sbjct: 208 NDLRLKVSEMDSERLQYEKKLKSTKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEI 267
Query: 351 AEWLDDAKQKLQQTLQKAETLPEIEAQ-LAQRVAALNKAEERHGNFEERLRQLEAQLEEK 409
+ ++ K+KL++ IE Q + + V +L A E E LRQ + ++
Sbjct: 268 VDRDENFKKKLKE--------KNIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKM 319
Query: 410 NQELQRARQREKMNDDHNKRL-SETVDKLL 438
+ A+ ++ + ++ + L S ++ LL
Sbjct: 320 QDTVVLAQGKKGKDGEYEELLNSSSISSLL 349
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 101 bits (251), Expect = 5e-21
Identities = 132/479 (27%), Positives = 218/479 (45%), Gaps = 58/479 (12%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
+L+ + +R+RL E +A A + L + + L+ + S+ L +E +
Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV-LAKELVEVR 686
Query: 87 KELN---LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP 143
+ L+ L R+ L + E+AE + R+ LE + E SL+ ++ K A +
Sbjct: 687 EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNE 746
Query: 144 GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLS 203
++++ + + L E AL + R R A + V EE E E L L ++++
Sbjct: 747 SLAQDKLDLNRLVAQLEEEKSAL----QGRQRQAEQEATVAREEQE--RLEELRLEQEVA 800
Query: 204 RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ----RAEVCQLRERLAVL 259
R+ GLE S R + +EALE+Q R E QL+E+LA L
Sbjct: 801 RQ--GLE-------------------GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
RQ+S E+EL A RE + EA + R+ KEALA+ L + ++A+RE
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAARE-KEALAKEH------AGLAVQLVAAEREG 892
Query: 320 TSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKL----QQTLQKAETLP-EI 374
+L + +L E KE+L E RQLA+ L+ +++L Q L ETL E+
Sbjct: 893 RTLSEEATRLRLE---KEALEGSLFEVQRQLAQ-LEARREQLEAEGQALLLAKETLTGEL 948
Query: 375 EAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLS-ET 433
Q +A KA ++L Q E + + +E + A + + K +
Sbjct: 949 AGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRE 1008
Query: 434 VDKLLSESNERLQLHLKERMGALE-EKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
++ ++ +LQ +E + LE EK LSEEIA +++ +DE L LLAE E+ Q
Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGL-----LLAESEKQQ 1062
Score = 94.4 bits (233), Expect = 6e-19
Identities = 165/670 (24%), Positives = 267/670 (39%), Gaps = 145/670 (21%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKD--SLQRQLSIA---LPQEFAALTKELNLCRE 94
++L++ REAQ A LR + HE+D LQR+ A L E A L +L +E
Sbjct: 971 QKLVQAEREAQ-----ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025
Query: 95 QLLER--------EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGV 146
+LL R EEIA L+ ER+ LL E S +++L + ++ A S +
Sbjct: 1026 ELLARLEAEKEELSEEIAALQQERDEGLLLAE------SEKQQALSLKESEKTALSEKLM 1079
Query: 147 SSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRR 206
+ L + E K + +E+ R + + +L +E Q RR
Sbjct: 1080 GTR-HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR- 1137
Query: 207 SGLEEPGKDGDGQTLANGLGPGGDSNRRTAE--------LEEALERQRAEVCQLRERLAV 258
L+E +D LG DS R AE LE+A + R E+ + + +L
Sbjct: 1138 --LQEQARD---------LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186
Query: 259 LCRQMSQLEEELGTAHRELGKA-------EEANSKLQRDLKEALAQR-------EDMEER 304
+E G R LG+ +N +L+ +K+A ++R ED E++
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
Query: 305 ITTLEKRYLSAQREATSLH-----------DANDKLENELASKESLYRQSEEKSRQLAEW 353
+ LE+ + +EA L +A +L+ + L ++ R+LAE
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
Query: 354 -----LDDAKQK--------LQQTLQKAETLPEI---EAQLAQRVAALNKAEERHGNFEE 397
L + +K L+Q L K E E+ E Q+AQR K +E+ G F
Sbjct: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR-----KLQEQEGEFRT 1361
Query: 398 RLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALE 457
R R+L LEE AR EK DH + L ++ +E+ E L R+ A E
Sbjct: 1362 RERRLLGSLEE-------ARGTEKQQLDHARGLELKLEAARAEAAE-----LGLRLSAAE 1409
Query: 458 EKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELR 517
+ E A + +++ + + QL ++ + GR PS R +PGS
Sbjct: 1410 GRAQGLE--AELARVEVQRRAAEAQLGGLRSALRRGLG--LGRAPSPAPRPVPGSPAR-- 1463
Query: 518 YSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGS 577
AP SG L+ S +P P P P S
Sbjct: 1464 --DAPAEGSGEGLN----------------------SPSTLECSPGSQPPSPGPATSPAS 1499
Query: 578 DEEEAEGMFGA------ELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRA 631
+ + E + GA EL S + D L+ Q A+N+++ ++ E+++ RA
Sbjct: 1500 PDLDPEAVRGALREFLQELRSAQRERD------ELRTQTSALNRQLAEMEAERDSATSRA 1553
Query: 632 EELESRVSSS 641
+L+ V+ S
Sbjct: 1554 RQLQKAVAES 1563
Score = 82.8 bits (203), Expect = 2e-15
Identities = 116/513 (22%), Positives = 217/513 (42%), Gaps = 34/513 (6%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
E + LRE L +AQ EL + +L RQL+ + E + T ++ + E
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLA-EMEAERDSATSRARQLQKAVAES 1563
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTV--VKRQAQSPGGVSSEVEVLKALK 157
EE + + + L E V R ER R T+ V +S SE+ +
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKI 1623
Query: 158 SLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD 217
S + ++ E + RL+ L+ +LEL + +L +L R R GL + ++
Sbjct: 1624 SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR---SLEGELQRSRLGLSD--REAQ 1678
Query: 218 GQTLANGLGP----GGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTA 273
Q L + + DS + L+ +ER + ++ E L ++ L E L +
Sbjct: 1679 AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQS 1738
Query: 274 HRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENEL 333
L + N LQ+ L R+ ++ER+ + A+++++SL + L E+
Sbjct: 1739 SASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEV 1798
Query: 334 ASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHG 393
A E ++E + +QL E L ++ L + L + L +R+ +L +A +
Sbjct: 1799 ADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLE 1858
Query: 394 NFEERLRQLEAQLEEKNQELQRAR---QREKM-NDDHNKRLSETVDKL----------LS 439
+ + + +LE+ L+R +REK+ + + RLS +L L+
Sbjct: 1859 AEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELA 1918
Query: 440 ESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEID---- 495
E+ ++Q L+ ++ LE+ +S ++ + ++ Q EL E+L + + + ++
Sbjct: 1919 EAQRQIQ-QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
Query: 496 --QLRGRPPSSYSRSLPGS-ALELRYSQAPTLP 525
+ R R +L G ELR S AP P
Sbjct: 1978 AHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSP 2010
Score = 79.7 bits (195), Expect = 2e-14
Identities = 152/644 (23%), Positives = 267/644 (41%), Gaps = 79/644 (12%)
Query: 29 ERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKE 88
ER ++ + E R ++EA GL+T LRL E E +L++Q AL Q A L ++
Sbjct: 318 ERDLLQLGGELARTSRAVQEAGLGLSTG-LRLAESRAEA-ALEKQ---ALLQ--AQLEEQ 370
Query: 89 LNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSS 148
L R+++L RE+++A+ + + + L+ + E L + +++Q V+
Sbjct: 371 L---RDKVL-REKDLAQQQMQSD-----LDKADLSARVTELGLAVKRLEKQNLEKDQVNK 421
Query: 149 EV-EVLKALKSL-FEHHKALDEKVRERLRMALERVAVL-----EEELELSNQE-TLNLRE 200
++ E L+AL+SL + AL+ + E L+ L +A E ++LS E T +
Sbjct: 422 DLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASN 481
Query: 201 QLSRRRSGLEEPG-----KDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRER 255
R SG P G G++ G P + A + AL +++ +V +R R
Sbjct: 482 GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGR 541
Query: 256 LAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSA 315
+ L ++L + E EE +L+ A+ ED A
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED--------------A 587
Query: 316 QREATSLHDANDKLENE---LASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLP 372
QRE L AN+ L E LA + +Q E+ RQ E L A+++L++ + E
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 373 EIEAQLAQRV-AALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLS 431
E Q RV L ++ + E + L +L E + L RA + M ++
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707
Query: 432 ETVDKL------LSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLA 485
E + K L S +L+ +L + ++L+E +A QD+L LN+
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLA-----QDKLDLNRLVAQL 762
Query: 486 EMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGR 545
E E+ ++ Q + ++ +R ELR Q + GS R ++ +
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG-------LEGSLRVAEQAQ 815
Query: 546 WSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIM 605
+ ++ P+ ERS + +L G ++E E Q V+ L
Sbjct: 816 EALEQQLPTLRHERSQLQEQL-AQLSRQLSGREQE-------LEQARREAQRQVEALERA 867
Query: 606 LQEQLEAINKE-----IKLIQEEKETTEQRAEELESRVSSSGLD 644
+E+ EA+ KE ++L+ E+E E R+ L+
Sbjct: 868 AREK-EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALE 910
Score = 70.5 bits (171), Expect = 9e-12
Identities = 99/443 (22%), Positives = 172/443 (38%), Gaps = 77/443 (17%)
Query: 140 AQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLR 199
A SP + E ++ F ++ R+ LR + E+E +
Sbjct: 1494 ATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRA 1553
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
QL + + EE + DG+ A EE++ R E +++A L
Sbjct: 1554 RQLQKAVAESEEARRSVDGRL--------SGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRD---LKEAL--------------------- 295
R + E EL + ++ K + +KL+ D LKE L
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL 1665
Query: 296 -----------AQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSE 344
AQ + +++R+ +L+++ ++ +A +L ++L LA E
Sbjct: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
Query: 345 EKSRQLAEWLDDAKQKLQQT------LQKAETLPEIEAQLAQR-----VAALNKAEERHG 393
+K R L E L + L T LQKA T E + Q+ Q AL++A ++
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSS 1785
Query: 394 NFEERLR-------QLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQ 446
+ E+++ LE Q E +LQ+ R+ + + TV KL E RL
Sbjct: 1786 SLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDE--RRL- 1842
Query: 447 LHLKERMGALE--------EKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
L+ER+G+L+ EK + ++K D + L + E E+++ D +R
Sbjct: 1843 --LQERLGSLQRALAQLEAEKREVERSALRLEK--DRVALRRTLDKVEREKLRSHEDTVR 1898
Query: 499 -GRPPSSYSRSLPGSALELRYSQ 520
R+L G+ LEL +Q
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQ 1921
Score = 58.5 bits (140), Expect = 4e-08
Identities = 86/367 (23%), Positives = 148/367 (40%), Gaps = 37/367 (10%)
Query: 29 ERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKE 88
E V + +R L L+ ++ GL+ + + + L DSLQRQ++ E A T +
Sbjct: 1648 ESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA---DSEVKAGTLQ 1704
Query: 89 LNLCR--EQLLEREEEIAELKAE-RNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
L + R L + EE L+ + R T L + L S +++L + +
Sbjct: 1705 LTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQ 1764
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRR 205
V E L A + + + E+++ VA LE + + + LRE L +R
Sbjct: 1765 VLQ--ERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
Query: 206 RSG----LEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCR 261
+ G L K D + L G R A+LE +L + L R
Sbjct: 1823 QEGEAAALNTVQKLQDERRLLQ--ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRR 1880
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQR-------DLKEALAQREDMEERITTLEKRY-- 312
+ ++E E +H + + +L R +L EA Q + +E ++ LE+ +
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940
Query: 313 -----------LSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKL 361
L Q+E L A + E L ++E +RQ + R L E + K +L
Sbjct: 1941 AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ---RVRGLEEQVSTLKGQL 1997
Query: 362 QQTLQKA 368
QQ L+++
Sbjct: 1998 QQELRRS 2004
Score = 53.9 bits (128), Expect = 9e-07
Identities = 114/508 (22%), Positives = 204/508 (40%), Gaps = 80/508 (15%)
Query: 38 ERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLL 97
E++RL +T E L +A +RL E ++Q S +L Q A L ++L+
Sbjct: 202 EQQRLRDT--EHSQDLESALIRLEE--------EQQRSASLAQVNAMLREQLDQAGSANQ 251
Query: 98 EREEEIAELKAERNNTRLLLEHLECLVSRHERSL---------------RMTVVKRQAQS 142
E+I ++ + R LEH E R E S R V R+ S
Sbjct: 252 ALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVS 311
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEK---VRERLRMALERV-AVLEEELELSNQETLNL 198
+ +E ++L+ L +A+ E + LR+A R A LE++ L Q L
Sbjct: 312 EVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL 371
Query: 199 REQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEA---LERQRAEVCQLRER 255
R+++ R KD Q + + L D + R EL A LE+Q E Q+ +
Sbjct: 372 RDKVLRE--------KDLAQQQMQSDLDK-ADLSARVTELGLAVKRLEKQNLEKDQVNKD 422
Query: 256 LAVLCRQMSQLE-EELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEK---- 310
L + L +E E G E + RDL +A+ + +++ E+
Sbjct: 423 LTEKLEALESLRLQEQAALETEDG---EGLQQTLRDLAQAVLSDSESGVQLSGSERTADA 479
Query: 311 -----RYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
R LS QR + ++ S + L + ++Q
Sbjct: 480 SNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMR 539
Query: 366 QKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQL-------EEKNQELQRAR- 417
+ E ++ L ++ L+ +E EE+L++L + E+ +E+QR R
Sbjct: 540 GRYEASQDLLGTLRKQ---LSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
Query: 418 -----QREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKL 472
REK N H+ ++++ + L + E+LQ +E +++ L EE
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEE---LRRQRDRLEEE------- 646
Query: 473 QDELLLNKEQLLAEMERMQMEIDQLRGR 500
Q++ + + ++ E+ER +++QL G+
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGK 674
Score = 49.7 bits (117), Expect = 2e-05
Identities = 106/473 (22%), Positives = 183/473 (38%), Gaps = 75/473 (15%)
Query: 131 LRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELEL 190
+R V + +Q V + +L SL E ++ L +++ R+ L + +EL +
Sbjct: 51 IREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQEL-SRVEDLLAQSRAERDELAI 109
Query: 191 SNQETLNLREQLSRRRSG---LEEP-GKDGDGQTLANGLGPGGDSNRRTAEL-EEALERQ 245
EQ R G +EP G L L S RR + +E +RQ
Sbjct: 110 KYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQ 169
Query: 246 RAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
V +L+ ++ ++ S+LE++L EL + +++ +DL+ AL + E+ ++R
Sbjct: 170 AQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229
Query: 306 TTLEKRYLSAQREATSLHDANDKL--------------ENELASKESLYRQSEEK----- 346
+L + + + AN L EL +E+ +R+ EE
Sbjct: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYF 289
Query: 347 ----SRQLAEW---------LDDAKQKLQQTL-----QKAETLPEIEAQLAQRVAALNKA 388
SR L W + + K ++ L + A T ++ L A
Sbjct: 290 SNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLA 349
Query: 389 EERHGNFEERLRQLEAQLEEKNQE--------LQRARQREKMNDDHNKRLSE---TVDKL 437
E R E+ L+AQLEE+ ++ Q+ Q + D + R++E V +L
Sbjct: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRL 409
Query: 438 LSESNERLQLH--LKERMGALEEKNSLSEEIA-----------NMKKLQDELLLNKE--- 481
++ E+ Q++ L E++ ALE L E+ A ++ L +L + E
Sbjct: 410 EKQNLEKDQVNKDLTEKLEALESLR-LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGV 468
Query: 482 QLLAEMERMQMEIDQLRG----RPPSSYSRSLPGSALELRYSQAPTLPSGAHL 530
QL LRG R PS RS PG R +P + L
Sbjct: 469 QLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521
Score = 42.4 bits (98), Expect = 0.003
Identities = 57/241 (23%), Positives = 97/241 (40%), Gaps = 51/241 (21%)
Query: 9 ISEDGRRGSALGPDEAG-----GELERLMVTMLTERERLLETLREAQDGLATAQLRLREL 63
+SE ++ S+LG +LE V + ++L E LR+ Q+G A A +++L
Sbjct: 1777 LSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL 1836
Query: 64 GHEKDSLQRQL--------------------SIALPQEFAALTKELNLCREQLLEREEEI 103
E+ LQ +L ++ L ++ AL + L+ + L E+
Sbjct: 1837 QDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDT 1896
Query: 104 AELKAERNNTRLLLEHLECLVSRHERSLR----MTVVKRQAQSPGGVSSEVEVLKALKSL 159
L AE+ L E ++ +R ++ VV Q+ SP + + +
Sbjct: 1897 VRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ-------- 1948
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRR-SGLEEPGKDGDG 218
+ L ++V ERLR A + + TL RE+ R+R GLEE G
Sbjct: 1949 -QQQLELQQEV-ERLRSA-----------QAQTERTLEARERAHRQRVRGLEEQVSTLKG 1995
Query: 219 Q 219
Q
Sbjct: 1996 Q 1996
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 100 bits (249), Expect = 8e-21
Identities = 100/478 (20%), Positives = 215/478 (44%), Gaps = 20/478 (4%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE+ + + L + + E Q +A +++L + E + ++ Q+ AL
Sbjct: 1045 ELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL- 1103
Query: 87 KELNLCREQLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQS 142
K++ Q+ E +E++ +A RN R L E LE L + E +L T +++ +S
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNL---R 199
EV +LK K+L E K + +++E + + V L E+LE + + NL +
Sbjct: 1164 KR--EQEVNILK--KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
+ L R L K L G G DS + ++E L+ + + + L
Sbjct: 1220 QTLENERGELANEVK-----VLLQGKG---DSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
++++L+ EL L +++ +SKL +D +Q +D +E + ++ LS +
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 320 TSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLA 379
+ D + +L +E E++ L + D K+K++ ++ ET E++ +L
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLS 439
+ + L++ E ++L + + +L+++ +L ++ + + ++ + D+LL+
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 440 ESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
E + +ER A E + ++ + +E + K +L ++ + E++ L
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Score = 95.9 bits (237), Expect = 2e-19
Identities = 121/483 (25%), Positives = 225/483 (46%), Gaps = 60/483 (12%)
Query: 23 EAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEF 82
E E E L + +++ L E + + + + R + L EK +Q+ + QE
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI-----QEL 948
Query: 83 AALTKELNLCREQL-LEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQ 141
+E R++L LE+ A+LK + +++LE C +++ ++ L R A+
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQIILEDQNCKLAKEKKLLE----DRIAE 1003
Query: 142 SPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ 201
++ E E K+L L H+A+ + ERLR ++ LE+ ++ +L +Q
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 202 LSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLR---ERLAV 258
++ ++ + E L L ++ EL+ AL R E Q +++
Sbjct: 1064 IAELQAQIAE---------LKMQLA------KKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEAL-AQREDMEERI-TTLEKRYLSAQ 316
L Q+S+L+E+L + KAE K +RDL E L A + ++E+ + +T ++ L ++
Sbjct: 1109 LESQISELQEDLESERASRNKAE----KQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 317 REATSLHDANDKLENELASKESLYRQSEEKSRQ----LAEWLDDAKQKLQQTLQKA-ETL 371
RE ++ LE E + E+ ++ +K Q LAE L+ K +++ L+KA +TL
Sbjct: 1165 RE-QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK-RVKANLEKAKQTL 1222
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLS 431
+LA V L + + G+ E + +++EAQL QELQ K N+ R +
Sbjct: 1223 ENERGELANEVKVLLQGK---GDSEHKRKKVEAQL----QELQ-----VKFNEGERVR-T 1269
Query: 432 ETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
E DK+ +LQ+ L G L + +S S ++ + L + ++LL E R +
Sbjct: 1270 ELADKV-----TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 492 MEI 494
+ +
Sbjct: 1325 LSL 1327
Score = 79.7 bits (195), Expect = 2e-14
Identities = 97/450 (21%), Positives = 185/450 (41%), Gaps = 58/450 (12%)
Query: 23 EAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQ-- 80
E ELERL TE E L+ + + + + R L + + ++ QL +
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 81 --EFAALTKELNLCR-----EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 133
E A L E+NL E+ L+ +E +E K ++ ++ E R +RS+ +
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 134 TVVKRQAQSPGGVSSEVEVL-----KALKSLFEHHKALDEKVRERLRMALERVAVL---- 184
K+ + + ++ +A+K L + + + +RE R +L
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 185 --EEELELSNQETLNLREQLSRRRSGLEEPGKDGD--GQTLANGLGPGGDS-------NR 233
E++L+ E + L+E+L+ + ++ D +AN G G +
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 234 RTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKE 293
R A+LEE LE ++ + +RL Q+ Q+ +L K E A +L+R KE
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789
Query: 294 ALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQ---SEEKSRQL 350
+ ++ME + + K ++A + ++L+NE +++ +Q +E+K + +
Sbjct: 1790 LKVKLQEMEGTVKSKYKASITALE--AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 351 AEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKN 410
+DD ++ +Q +A+ RL+QL+ QLEE
Sbjct: 1848 LLQVDDERRNAEQYKDQADKA------------------------STRLKQLKRQLEEAE 1883
Query: 411 QELQRARQREKMNDDHNKRLSETVDKLLSE 440
+E QRA + + +ET D + E
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNRE 1913
Score = 78.6 bits (192), Expect = 3e-14
Identities = 112/494 (22%), Positives = 208/494 (42%), Gaps = 54/494 (10%)
Query: 12 DGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQ 71
D +R SA ++ + ++L L E + + E +D A+ RE + SL
Sbjct: 1430 DHQRQSACNLEKKQKKFDQL----LAEEKTISAKYAEERD---RAEAEAREKETKALSLA 1482
Query: 72 RQLSIALPQ--EFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 129
R L A+ Q E L K+ E L+ ++++ + E ++ LE E
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ-----QVEEM 1537
Query: 130 SLRMTVVKRQAQSPGGVSSEVEV-LKALKSLFEHH-KALDEKVRERLRMALERVAVLEEE 187
++ ++ + Q+ +EV L+A+K+ FE + DE+ E+ + + +V +E E
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597
Query: 188 LELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRA 247
LE ++ R R LE KD + A ++ A + +
Sbjct: 1598 LEDERKQ----RSMAVAARKKLEMDLKDLE------------------AHIDSANKNRDE 1635
Query: 248 EVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITT 307
+ QLR+ A + M +L++ + L +A+E KL K A+ ++E +
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----KSMEAEMIQLQEELAA 1691
Query: 308 LEKRYLSAQREATSLHD--ANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
E+ AQ+E L D AN + LA +E R+ E + QL E L++ + +
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEK--RRLEARIAQLEEELEEEQGNTELIN 1749
Query: 366 QKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ-RARQREKMND 424
+ L + Q+ Q LN E H E RQ QLE +N+EL+ + ++ E
Sbjct: 1750 DR---LKKANLQIDQINTDLN-LERSHAQKNENARQ---QLERQNKELKVKLQEMEGTVK 1802
Query: 425 DHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLL 484
K ++ +++ E+L KER A ++ +++ ++ D+ N EQ
Sbjct: 1803 SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYK 1862
Query: 485 AEMERMQMEIDQLR 498
+ ++ + QL+
Sbjct: 1863 DQADKASTRLKQLK 1876
Score = 65.5 bits (158), Expect = 3e-10
Identities = 81/361 (22%), Positives = 153/361 (42%), Gaps = 47/361 (13%)
Query: 169 KVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEE--------PGKDGDGQT 220
KVRE+ A R+ +E E L L+EQL E K + +
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 221 LANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQ-------LEEELGTA 273
+ + D R E EE + +AE ++++ + L Q+ + L+ E T
Sbjct: 916 ICH------DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 274 HRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENEL 333
+L K EE L+ + +++ +E+RI + ++ SL +K E +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 334 ASKESLYRQSEEKSRQLAEWLDDAKQKLQ-QTLQKAETLPEIEAQLAQRVAALNKAEER- 391
E R+ EEK RQ L+ ++KL+ + ++ + E++AQ+A+ L K EE
Sbjct: 1030 TDLEERLRR-EEKQRQ---ELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL 1085
Query: 392 ---HGNFEE----------RLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
EE ++R+LE+Q+ E ++L+ R + + L E ++ L
Sbjct: 1086 QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK 1145
Query: 439 SESNERLQLHLKERMGALEEKNSLSEEIANM--KKLQDELLLNKEQLLAEMERMQMEIDQ 496
+E + L + A +E S E+ N+ K L++E ++ Q+ ++ +++
Sbjct: 1146 TELEDTL-----DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
Query: 497 L 497
L
Sbjct: 1201 L 1201
Score = 60.5 bits (145), Expect = 9e-09
Identities = 82/386 (21%), Positives = 160/386 (41%), Gaps = 23/386 (5%)
Query: 20 GPDEAGGELERLMVTMLTERERLLETLREAQDGLATA----QLRLRELGHEKDSLQRQLS 75
G DE E ++ +V + E E LE R+ + A ++ L++L DS +
Sbjct: 1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634
Query: 76 IALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLEC-LVSRHERSLRMT 134
A+ Q L ++ C +L + E+ A+ L+ +E ++ E
Sbjct: 1635 EAIKQ-LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 135 VVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQE 194
KRQAQ ++ + K AL+EK R R+A LEEELE
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGAL----ALEEK-----RRLEARIAQLEEELEEEQGN 1744
Query: 195 TLNLREQLSRRRSGLEEPGKDGDGQT--LANGLGPGGDSNRRTAELEEALERQRAEV-CQ 251
T + ++L + +++ D + + R+ EL+ L+ V +
Sbjct: 1745 TELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSK 1804
Query: 252 LRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQ----REDMEERITT 307
+ + L +++QLEE+L +E A + + ++ LK+ L Q R + E+
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 308 LEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQK 367
+K ++ L +A ++ + AS+ L R+ E+ + + A+ ++ L+ L++
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED-ATETADAMNREVSSLKNKLRR 1923
Query: 368 AETLPEIEAQLAQRVAALNKAEERHG 393
+ + ++A++ A EE G
Sbjct: 1924 GDLPFVVPRRMARKGAGDGSDEEVDG 1949
Score = 53.1 bits (126), Expect = 2e-06
Identities = 64/273 (23%), Positives = 125/273 (45%), Gaps = 51/273 (18%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEA-------LAQREDMEERITTLEKRYLS 314
Q+S+ EEE+ EL K E + L E +A++ ++E++ +
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 315 AQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEI 374
A+ L +LE E+ + EE+ + L K+K+QQ +Q E+
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQA----EKKKMQQNIQ------EL 948
Query: 375 EAQLAQRVAALNKAEERHGNFEERLRQLEAQ---LEEKNQELQRARQREKMND------- 424
E QL + +A K + E +L++LE + LE++N +L A++++ + D
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL--AKEKKLLEDRIAEFTT 1006
Query: 425 ------DHNKRLSETVDK---LLSESNERLQLHLKERMGALE--------EKNSLSEEIA 467
+ +K L++ +K ++++ ERL+ K+R LE + LS++IA
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ-ELEKTRRKLEGDSTDLSDQIA 1065
Query: 468 NMK----KLQDELLLNKEQLLAEMERMQMEIDQ 496
++ +L+ +L +E+L A + R++ E Q
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 100 bits (248), Expect = 1e-20
Identities = 102/462 (22%), Positives = 207/462 (44%), Gaps = 23/462 (4%)
Query: 48 EAQDGLATAQLRLRELGHEKDSLQRQLSIALPQ---EFAALTKELNLCRE---QLLEREE 101
+ QD +A Q ++ EL + + +L AL + E L + RE Q+ E +E
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 102 EIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALK 157
+ KA RN R L E LE L + E +L T +++ ++ E+ KAL+
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKALE 1184
Query: 158 SLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKD-- 215
++H+A + +R+R ALE L E+LE + + NL + + GLE K+
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEE---LSEQLEQAKRFKANLE----KNKQGLETDNKELA 1237
Query: 216 GDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHR 275
+ + L +S + +L+ ++ A+V + L + S+L+ EL
Sbjct: 1238 CEVKVLQQ---VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 276 ELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELAS 335
L +AE+ K +D +Q +D +E + ++ L+ L + + L+ +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 336 KESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNF 395
+E + E++ L L D K+K+ L E+L E + +L + AL++ E
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 396 EERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGA 455
++L + + +L+++ +L ++ + ++ + D+LL+E + +ER A
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 456 LEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
E + ++ + +E L KE+ + ++++ +++ L
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 89.7 bits (221), Expect = 1e-17
Identities = 118/505 (23%), Positives = 217/505 (42%), Gaps = 65/505 (12%)
Query: 55 TAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTR 114
TA+ +++++ E L+ Q S + +E + + C QL E EE+ L RN
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFI-KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 115 LLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERL 174
+++ LE + + E++ R + K + + G + + + L++ + K K E L
Sbjct: 1034 VMISDLEERLKKEEKT-RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092
Query: 175 RMALER---------------------VAVLEEELELSNQETLNLREQLSRRRSGLEEPG 213
+ AL R +A L+E+ E S + + N E+ R S E
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFE-SEKASRNKAEKQKRDLSEELEAL 1151
Query: 214 KDGDGQTLANGLGPGGDSNRR---TAELEEALERQ----RAEVCQLRERLAVLCRQMSQL 266
K TL +R AEL++ALE + A++ +R+R A + +L
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT---ALEEL 1208
Query: 267 EEELGTAHRELGKAEEANSKLQRDLKEALAQ--------------REDMEERITTLEKRY 312
E+L A R E+ L+ D KE + R+ ++ ++ L +
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 313 LSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLP 372
R L + KL+NEL + +L ++E+K + A+ + +LQ T + +
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 373 EIEAQLAQRVAAL----NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHN- 427
+ L+ R+ L N +E+ EE + LE Q+ +L A ++K++DD
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL--ADTKKKVDDDLGT 1386
Query: 428 -KRLSETVDKLLSESNERLQLHLKERMGALEE----KNSLSEEIANMKKLQDELLLNKEQ 482
+ L E KLL ++ E L L+E+ A ++ KN L +E+ ++ D ++ Q
Sbjct: 1387 IESLEEAKKKLLKDA-EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD----HQRQ 1441
Query: 483 LLAEMERMQMEIDQLRGRPPSSYSR 507
+ + +E+ Q + DQL S +R
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISAR 1466
Score = 83.2 bits (204), Expect = 1e-15
Identities = 126/534 (23%), Positives = 227/534 (42%), Gaps = 120/534 (22%)
Query: 5 VMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELG 64
V + E ++G D A E + L + + LL+ + L++ R+R+L
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLE------SQLQDTQELLQEETRQKLNLSS---RIRQLE 1342
Query: 65 HEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLV 124
EK+SLQ Q +E K L +Q+L + ++A+ K + ++ +E LE
Sbjct: 1343 EEKNSLQEQ-----QEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLE--- 1391
Query: 125 SRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVL 184
+A K L + +AL +++ E+ +A +++
Sbjct: 1392 -----------------------------EAKKKLLKDAEALSQRLEEK-ALAYDKLEKT 1421
Query: 185 EEELELSNQETLNLREQLSRRR---SGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEA 241
+ L+ QE +L L +R S LE+ K D Q LA ++ A
Sbjct: 1422 KNRLQ---QELDDLTVDLDHQRQVASNLEKKQKKFD-QLLA---------EEKSISARYA 1468
Query: 242 LERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDM 301
ER RAE + RE+ LEE L + E N +L+ D+++ ++ ++D+
Sbjct: 1469 EERDRAE-AEAREKETKALSLARALEEALEAKE----EFERQNKQLRADMEDLMSSKDDV 1523
Query: 302 EERITTLEKRYLSAQREATSLHDANDKLENELASKESLY--------------------- 340
+ + LEK + +++ + ++LE+EL + E
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583
Query: 341 -RQSEEKSRQL--------AEWLDDAKQKLQQTLQKAE---TLPEIEAQLAQRVAALNKA 388
Q+EEK R L AE D+ KQ+ K + L ++EAQ + A NKA
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ----IEAANKA 1639
Query: 389 EERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLH 448
+ ++LR+L+AQ+++ +EL+ AR D+ + E+ KL S E LQL
Sbjct: 1640 RD---EVIKQLRKLQAQMKDYQRELEEAR---ASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 449 ------LKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQ 496
+ R A +E++ L++EI N + LL K +L A + +++ E+++
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE 1747
Score = 79.0 bits (193), Expect = 3e-14
Identities = 86/350 (24%), Positives = 155/350 (44%), Gaps = 50/350 (14%)
Query: 178 LERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAE 237
L +V EEEL+ ++E L ++E+ ++ LEE + Q L + AE
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQ-QLL--------EEKNILAE 894
Query: 238 LEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQ 297
+A AE ++R RLA + +LEE L + + EE N LQ + K+ A
Sbjct: 895 QLQAETELFAEAEEMRARLAA---KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 298 REDMEERI--------------TTLEKRYLSAQREATSLHDANDK-------LENELASK 336
+D+EE++ T E + + E L D N K +E+ +A
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 337 ESLYRQSEEKSRQLAEWLDDAK---QKLQQTLQKAE-TLPEIEAQLAQRVAALNKAEERH 392
S + EEK++ LA+ + + L++ L+K E T E+E + +++
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 393 GNFEERLRQLEAQLEEKNQELQRARQR---EKMNDDHNKRLSETVDKLLSESNERLQLHL 449
+ ++ +L+ QL +K +ELQ A R E ++ ++ ++ + ++E E +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 450 KERMGALEEKNSLSEEIANMK----------KLQDELLLNKEQLLAEMER 489
R A ++K LSEE+ +K Q EL +EQ +AE+++
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Score = 76.6 bits (187), Expect = 1e-13
Identities = 176/695 (25%), Positives = 296/695 (42%), Gaps = 131/695 (18%)
Query: 56 AQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELK-AERNNTR 114
A+ + R+L E ++L+ +L L + A +EL +RE+E+AELK A T+
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTL--DTTAAQQELRT------KREQEVAELKKALEEETK 1188
Query: 115 LLLEHLECLVSRH-----ERSLRMTVVKR-----QAQSPG------GVSSEVEVLKALKS 158
++ + RH E S ++ KR + G ++ EV+VL+ +K+
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 159 LFEH-HKALDEKVRE---------RLRMAL-ERVAVLEEELELSNQETLNLRE------Q 201
EH K LD +V+E RLR+ L E+ + L+ EL+ N TL L E +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD--NVSTL-LEEAEKKGIK 1305
Query: 202 LSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE---ALERQRAEVCQLRERLA- 257
++ + LE +D + L + + R +LEE +L+ Q+ E + R+ L
Sbjct: 1306 FAKDAASLESQLQDTQ-ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 258 -VLCRQMSQLEEELGTAHRELG---KAEEANSKLQRDLKEALAQR-EDMEERITTLEKRY 312
VL Q SQL + +LG EEA KL +D EAL+QR E+ LEK
Sbjct: 1365 QVLALQ-SQLADTKKKVDDDLGTIESLEEAKKKLLKDA-EALSQRLEEKALAYDKLEKTK 1422
Query: 313 LSAQRE--------------ATSLHDANDKLENELASKESLY-RQSEEKSRQLAEWLDDA 357
Q+E A++L K + LA ++S+ R +EE+ R AE +
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 358 KQKLQ--QTLQKA-ETLPEIEAQLAQRVAAL--------------NKAEERHGNFEERLR 400
+ L + L++A E E E Q Q A + ++ E+ E+++
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 401 QLEAQLEEKNQELQR---ARQREKMN---------------DDHNKRLSETVDKLLSESN 442
++ QLEE ELQ A+ R ++N D+ N+ + K + E
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602
Query: 443 ERLQLHLKERMGALEEKNSLSEEIANMK-------KLQDELLLNKEQLLAEMERMQMEID 495
L+ K+R A+ K + ++ +++ K +DE++ +L A+M+ Q E++
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 496 QLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSK 555
+ R +++S S +L+ +A L L +A S RA + ++E +
Sbjct: 1663 EARASRDEIFAQS-KESEKKLKSLEAEIL----QLQEELASSERARRHAEQE--RDELAD 1715
Query: 556 DWERSAPAGSIPPPFPGELDGS----DEEEAEGMFGAELLSP---SGQADVQTLAIMLQE 608
+ SA S L+ +EE E ELL+ V TL L
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775
Query: 609 QLEAINKEIKLIQE-EKETTEQRA--EELESRVSS 640
+ A K Q+ E++ E +A +ELE V S
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Score = 75.9 bits (185), Expect = 2e-13
Identities = 94/469 (20%), Positives = 196/469 (41%), Gaps = 46/469 (9%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALP--QEFAALTKELNLC 92
+L E + + E +D A+ RE + SL R L AL +EF K+L
Sbjct: 1456 LLAEEKSISARYAEERD---RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 93 REQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEV 152
E L+ ++++ + E ++ LE E ++ ++ + Q+ +EV
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQ-----QVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 153 -LKALKSLFEHH-KALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLE 210
++A+K+ FE + DE+ E+ R+ +++V LE ELE ++ R + +E
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ----RALAVASKKKME 1623
Query: 211 EPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEEL 270
KD + Q EA + R EV +Q+ +L+ ++
Sbjct: 1624 IDLKDLEAQI-------------------EAANKARDEVI----------KQLRKLQAQM 1654
Query: 271 GTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLE 330
REL +A + ++ KE+ + + +E I L++ S++R D+L
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+E+ + S ++ R+L + +++L++ E L + + +V LN
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 391 RHGNFEERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRLSETVDKLLSESNERLQLHL 449
+ ++ QLE +N+EL+ + ++ E K ++ + + E+L+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 450 KERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
KER A + +++ + ++ + +Q +ME+ + QL+
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 75.5 bits (184), Expect = 3e-13
Identities = 109/461 (23%), Positives = 192/461 (41%), Gaps = 77/461 (16%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGL-ATAQLRLRELGHEKDSLQRQLSIALPQEFAAL 85
ELE+ + + E + L E +D L AT +LR L + + A
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR------------LEVNMQAMKAQF 1576
Query: 86 TKELNLCREQLLERE----EEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQ 141
++L EQ E++ +++ EL+AE + R L ++ + + + +AQ
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDER----KQRALAVASKKKMEIDLKDLEAQ 1632
Query: 142 SPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEE---ELELSNQETLNL 198
+ EV+K L+ L K ++ E E A +E +L+ E L L
Sbjct: 1633 IEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL 1692
Query: 199 REQLSR----RRSGLEEPGKDGDGQT-LANGLGPGGDSNRRT----AELEEALERQRAEV 249
+E+L+ RR +E + D T A+G D RR A+LEE LE +++ +
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 250 CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLE 309
L +R Q+ L EL K++ A +L+R KE A+ +++E + +
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF 1812
Query: 310 KRYLSA-QREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKA 368
K +SA + + L + ++ E A+ L R++E+K +++ ++D ++ Q ++
Sbjct: 1813 KATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQM 1872
Query: 369 ETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRA----RQREKMND 424
E R++QL+ QLEE +E RA R+ ++ D
Sbjct: 1873 EKA------------------------NARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Query: 425 D---HNKRLSETVDKL------------LSESNERLQLHLK 450
D N+ LS V L S + R QLHL+
Sbjct: 1909 DATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLE 1949
Score = 60.8 bits (146), Expect = 7e-09
Identities = 83/395 (21%), Positives = 159/395 (40%), Gaps = 40/395 (10%)
Query: 22 DEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQE 81
DE E +RL++ + E E LE R+ Q LA A + E+ + L+ Q+ A
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERK-QRALAVASKKKMEI--DLKDLEAQIEAANKAR 1640
Query: 82 FAALTKELNLCREQLLEREEEIAELKAERNN-------TRLLLEHLECLV---------- 124
+ K+L + Q+ + + E+ E +A R+ + L+ LE +
Sbjct: 1641 DEVI-KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 125 ---SRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLF-------EHHKALDEKVRERL 174
RH R + S G S+ ++ + L++ E ++ E + +R
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759
Query: 175 RMALERVAVLEEELELSN---QETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDS 231
R +V L EL Q++ N R+QL R+ L+ ++ +G +
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 232 NRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDL 291
+ +LEE LE++ E + + +++ ++ ++ R + +E K +
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 292 KEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQ------SEE 345
K+ Q E+ EE T QRE +AN+ L E+++ ++ R+ S
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSS 1939
Query: 346 KSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQ 380
+S + L+ A +L +++T E Q Q
Sbjct: 1940 RSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQ 1974
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 99.4 bits (246), Expect = 2e-20
Identities = 133/499 (26%), Positives = 229/499 (45%), Gaps = 53/499 (10%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE MVT+L E+ L ++ +GLA A+ R +L K +Q + I E A
Sbjct: 878 ELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQL--IKTKIQLEAKIKEVTERAEDE 935
Query: 87 KELNL-CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
+E+N + + E+E +ELK + ++ L L +E E+ VK + G
Sbjct: 936 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAG 990
Query: 146 VSSEVEVL-KALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLNL 198
+ + L K K+L E H + LD+ E L A ++ ++LE S ++ L
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 199 REQLSRRRSGLEEPGK---------DGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV 249
R L R + LE K + + Q L L + L+ +E ++A
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK---KEFEISNLQSKIEDEQALG 1107
Query: 250 CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED----MEERI 305
QL++++ L ++ +LEEE+ KAE+ S L R+L+E + E+ +I
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD---AKQKLQ 362
+KR Q+ L +A L++E A+ +L ++ + +L E +D+ KQKL+
Sbjct: 1168 EMNKKREAEFQKMRRDLEEAT--LQHE-ATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 363 QTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKM 422
+ +K+E EI+ LA V ++KA+ GN E+ R LE QL E + Q+ +
Sbjct: 1225 K--EKSEMKMEID-DLASNVETVSKAK---GNLEKMCRTLEDQLSELKS--KEEEQQRLI 1276
Query: 423 NDDHNKRLSETVDKLLSESNE-RLQLHLKERMGA--LEEKNSLSEEIANMKKLQDELLLN 479
ND L+ +L +ES E QL KE + + K + +++I +K+ +E +
Sbjct: 1277 ND-----LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 480 KEQLLAEMERMQMEIDQLR 498
K L ++ + + D LR
Sbjct: 1332 KNALAHALQSSRHDCDLLR 1350
Score = 76.3 bits (186), Expect = 2e-13
Identities = 113/536 (21%), Positives = 228/536 (42%), Gaps = 82/536 (15%)
Query: 22 DEAGGELER-LMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQ 80
D+ G LE+ + M ER + R+ + L AQ + ++ +EK L +L +
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAK-----RKLEGDLKLAQESIMDIENEKQQLDEKLK---KK 1089
Query: 81 EFAALTKELNLCREQLL---------EREEEIAELKAERNNTRLLLEHLECLVSRHERSL 131
EF + + EQ L E + I EL+ E R E S R L
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 132 RMTVVKRQAQSPGGVSSEVEVLKALKSLFE-----------HHKALDEKVRERLRMALER 180
+ +R ++ G S+++E+ K ++ F+ H+A +R++ +
Sbjct: 1150 E-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK---HADS 1205
Query: 181 VAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE 240
VA L E+++ + L ++ S + +++ + + + A G + + LE+
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-----NLEKMCRTLED 1260
Query: 241 ALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED 300
L +++ + + + L Q +L+ E G R+L + E S+L R + Q E+
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 301 MEERITT-LEKRYLSAQREATSLHDAN---DKLENELASKESLYRQSEEKSRQLAEW--- 353
++ ++ ++ + A +S HD + ++ E E SK L R + + ++A+W
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 354 -----------LDDAKQKLQQTLQKAE-----------TLPEIEAQLAQRV--------- 382
L++AK+KL Q LQ AE +L + + +L V
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 383 --AALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSE 440
AA +++ NF++ L + + + EE + EL+ +++ + ++ + E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE----E 1496
Query: 441 SNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQ 496
S ++L+ +E +E + L+E+IA K EL K+Q+ E +Q +++
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Score = 73.6 bits (179), Expect = 1e-12
Identities = 105/510 (20%), Positives = 210/510 (41%), Gaps = 66/510 (12%)
Query: 22 DEAGGELERLMVTMLTERERLLETLRE------AQDGLATAQLRLR------ELGHEKDS 69
+EAGG + M +RE + +R Q A LR + ELG + D+
Sbjct: 1157 EEAGGATSA-QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNT-RLLLEHLECLVSRHE 128
LQR + Q+ E+ + + L E +++ K R L + L L S+ E
Sbjct: 1216 LQR-----VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE 1270
Query: 129 RSLRM----TVVKRQAQSPGG-VSSEVEVLKALKSLFEHHK-ALDEKVRERLRMALERVA 182
R+ T + + Q+ G S +++ +AL S K A +++ E R E +
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330
Query: 183 V---LEEELELSNQETLNLREQLSRRRSG---LEEPGKDGDGQTLANGLGPGGDSNRRTA 236
L L+ S + LREQ + L+ + + D+ +RT
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390
Query: 237 ELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALA 296
ELEEA ++ L +++ EE + + + E+ +LQ ++++ +
Sbjct: 1391 ELEEAKKK--------------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 297 QREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD 356
E L+K+ + + L + K E A E+ S++++R L L
Sbjct: 1437 DVERTNAACAALDKKQRNFDK---ILAEWKQKCEETHAELEA----SQKEARSLGTELFK 1489
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRA 416
K +++L + ETL L Q ++ L + G L +++ Q+E++ ELQ A
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 417 RQREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEE 465
+ + + +H + ++ VD+ ++E +E + + + +E S +
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD- 1608
Query: 466 IANMKKLQDELLLNKEQLLAEMERMQMEID 495
A ++ D + L K+++ ++ M+++++
Sbjct: 1609 -AEIRSRNDAIRL-KKKMEGDLNEMEIQLN 1636
Score = 66.6 bits (161), Expect = 1e-10
Identities = 96/471 (20%), Positives = 201/471 (42%), Gaps = 74/471 (15%)
Query: 59 RLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE 118
+L L E +LQ+++S L ++ A K ++ + + E+E EL+A LE
Sbjct: 1500 QLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 119 HLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMAL 178
H E + R + L V SEV+ + + E + +D+ R +R+
Sbjct: 1559 HEEGKILRIQLELNQ------------VKSEVD-----RKIAEKDEEIDQLKRNHIRIVE 1601
Query: 179 ERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD---GQTLANGLGPGGDSNRRT 235
+ L+ E+ S + + L++++ + +E + + L N G
Sbjct: 1602 SMQSTLDAEIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 236 AELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT--------------AHRELGKAE 281
L++AL Q L+E+LA++ R+ + L+ E+ A +EL A
Sbjct: 1661 IHLDDALRSQE----DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 282 E--------------ANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDAND 327
E KL+ D+ + + ED+ + E++ A +A + +
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 328 KLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNK 387
K ++ A E + + E+ + L LD+A+Q + +K + ++EA++ + +
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK--QIQKLEARVRELEGEVES 1834
Query: 388 AEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQL 447
++R+ + LR+ E +++E + + R+ + RL + VDKL +++
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRK-------NILRLQDLVDKL----QAKVKS 1883
Query: 448 HLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
+ ++ A E+ N+ +A +KLQ EL E+ + + ++++LR
Sbjct: 1884 YKRQAEEAEEQSNT---NLAKFRKLQHEL----EEAEERADIAESQVNKLR 1927
Score = 57.8 bits (138), Expect = 6e-08
Identities = 53/231 (22%), Positives = 109/231 (47%), Gaps = 31/231 (13%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQREATSLHDANDKLE 330
+E+ +E K++ +L ++ A+R+++EE++ TL K L Q EA L DA ++ +
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+ +K L + K+++ ++AE EI A+L A K E+
Sbjct: 913 QLIKTKIQL------------------EAKIKEVTERAEDEEEINAEL---TAKKRKLED 951
Query: 391 RHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK 450
++ + LE L + +E + K + L ET+ KL E + H +
Sbjct: 952 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 451 --ERMGALEEK-NSLSEEIANMKKLQDEL---LLNKEQLLAEMERMQMEID 495
+ + A E+K N+L++ +++ D+L L +++L ++ER + +++
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/257 (23%), Positives = 126/257 (49%), Gaps = 46/257 (17%)
Query: 261 RQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQ 316
++M+ ++EE EL K+E A+R+++EE++ TL K L Q
Sbjct: 853 KEMATMKEEFQKIKDELAKSE--------------AKRKELEEKMVTLLKEKNDLQLQVQ 898
Query: 317 REATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD----------AKQKLQ-QTL 365
EA L DA ++ + + +K L E K +++ E +D K+KL+ +
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQL----EAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 366 QKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE---AQLEEKNQELQRARQREKM 422
+ + + ++E LA+ + E + N E + L+ A+L ++ + LQ A Q + +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ-QTL 1013
Query: 423 NDDHNKRLSETVDKL--LSESNERLQLHLKERMGALEEKNSLSEEIANMK-KLQDELLLN 479
+D L DK+ L+++ +L+ + + G+LE++ L ++ K KL+ +L L
Sbjct: 1014 DD-----LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 480 KEQLLAEMERMQMEIDQ 496
+E ++ ++E + ++D+
Sbjct: 1069 QESIM-DIENEKQQLDE 1084
Score = 45.1 bits (105), Expect = 4e-04
Identities = 79/336 (23%), Positives = 144/336 (42%), Gaps = 59/336 (17%)
Query: 88 ELNLCREQLLEREEEIAELKAERNNTRLLLE----HLE-CLVSRHERSLRMTVVKRQAQS 142
+LN QL AE NT+ +L+ HL+ L S+ + ++ +V+R+A
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVL----------EEELELSN 192
+ +E+E L+A E + + E + L A ERV +L +++LE
Sbjct: 1687 ---LQAEIEELRATLEQTERSRKIAE---QELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 193 QETLNLREQLSRRRSGLEEPGKDG--DGQTLANGLGPGGDSNRRTAELEEALERQRAEVC 250
+ E + + EE K D +A L D++ +++ +E Q +
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME-QTVKDL 1799
Query: 251 QLR----ERLAV---------LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQ 297
QLR E+LA+ L ++ +LE E+ + + +A + K +R +KE Q
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859
Query: 298 REDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSR-QLAEWLDD 356
E+ + I L+ D DKL+ ++ S + ++EE+S LA++
Sbjct: 1860 TEEDRKNILRLQ--------------DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF--- 1902
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH 392
+KLQ L++AE +I ++ K+ E H
Sbjct: 1903 --RKLQHELEEAEERADIAESQVNKLRV--KSREVH 1934
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 99.4 bits (246), Expect = 2e-20
Identities = 133/499 (26%), Positives = 229/499 (45%), Gaps = 53/499 (10%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE MVT+L E+ L ++ +GLA A+ R +L K +Q + I E A
Sbjct: 878 ELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQL--IKTKIQLEAKIKEVTERAEDE 935
Query: 87 KELNL-CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
+E+N + + E+E +ELK + ++ L L +E E+ VK + G
Sbjct: 936 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAG 990
Query: 146 VSSEVEVL-KALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLNL 198
+ + L K K+L E H + LD+ E L A ++ ++LE S ++ L
Sbjct: 991 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 199 REQLSRRRSGLEEPGK---------DGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV 249
R L R + LE K + + Q L L + L+ +E ++A
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK---KEFEISNLQSKIEDEQALG 1107
Query: 250 CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED----MEERI 305
QL++++ L ++ +LEEE+ KAE+ S L R+L+E + E+ +I
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD---AKQKLQ 362
+KR Q+ L +A L++E A+ +L ++ + +L E +D+ KQKL+
Sbjct: 1168 EMNKKREAEFQKMRRDLEEAT--LQHE-ATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 363 QTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKM 422
+ +K+E EI+ LA V ++KA+ GN E+ R LE QL E + Q+ +
Sbjct: 1225 K--EKSEMKMEID-DLASNVETVSKAK---GNLEKMCRTLEDQLSELKS--KEEEQQRLI 1276
Query: 423 NDDHNKRLSETVDKLLSESNE-RLQLHLKERMGA--LEEKNSLSEEIANMKKLQDELLLN 479
ND L+ +L +ES E QL KE + + K + +++I +K+ +E +
Sbjct: 1277 ND-----LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 480 KEQLLAEMERMQMEIDQLR 498
K L ++ + + D LR
Sbjct: 1332 KNALAHALQSSRHDCDLLR 1350
Score = 76.3 bits (186), Expect = 2e-13
Identities = 113/536 (21%), Positives = 228/536 (42%), Gaps = 82/536 (15%)
Query: 22 DEAGGELER-LMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQ 80
D+ G LE+ + M ER + R+ + L AQ + ++ +EK L +L +
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAK-----RKLEGDLKLAQESIMDIENEKQQLDEKLK---KK 1089
Query: 81 EFAALTKELNLCREQLL---------EREEEIAELKAERNNTRLLLEHLECLVSRHERSL 131
EF + + EQ L E + I EL+ E R E S R L
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1149
Query: 132 RMTVVKRQAQSPGGVSSEVEVLKALKSLFE-----------HHKALDEKVRERLRMALER 180
+ +R ++ G S+++E+ K ++ F+ H+A +R++ +
Sbjct: 1150 E-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK---HADS 1205
Query: 181 VAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEE 240
VA L E+++ + L ++ S + +++ + + + A G + + LE+
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-----NLEKMCRTLED 1260
Query: 241 ALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED 300
L +++ + + + L Q +L+ E G R+L + E S+L R + Q E+
Sbjct: 1261 QLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 301 MEERITT-LEKRYLSAQREATSLHDAN---DKLENELASKESLYRQSEEKSRQLAEW--- 353
++ ++ ++ + A +S HD + ++ E E SK L R + + ++A+W
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 354 -----------LDDAKQKLQQTLQKAE-----------TLPEIEAQLAQRV--------- 382
L++AK+KL Q LQ AE +L + + +L V
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 383 --AALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSE 440
AA +++ NF++ L + + + EE + EL+ +++ + ++ + E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE----E 1496
Query: 441 SNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQ 496
S ++L+ +E +E + L+E+IA K EL K+Q+ E +Q +++
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Score = 73.6 bits (179), Expect = 1e-12
Identities = 105/510 (20%), Positives = 210/510 (41%), Gaps = 66/510 (12%)
Query: 22 DEAGGELERLMVTMLTERERLLETLRE------AQDGLATAQLRLR------ELGHEKDS 69
+EAGG + M +RE + +R Q A LR + ELG + D+
Sbjct: 1157 EEAGGATSA-QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNT-RLLLEHLECLVSRHE 128
LQR + Q+ E+ + + L E +++ K R L + L L S+ E
Sbjct: 1216 LQR-----VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE 1270
Query: 129 RSLRM----TVVKRQAQSPGG-VSSEVEVLKALKSLFEHHK-ALDEKVRERLRMALERVA 182
R+ T + + Q+ G S +++ +AL S K A +++ E R E +
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330
Query: 183 V---LEEELELSNQETLNLREQLSRRRSG---LEEPGKDGDGQTLANGLGPGGDSNRRTA 236
L L+ S + LREQ + L+ + + D+ +RT
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390
Query: 237 ELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALA 296
ELEEA ++ L +++ EE + + + E+ +LQ ++++ +
Sbjct: 1391 ELEEAKKK--------------LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 297 QREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD 356
E L+K+ + + L + K E A E+ S++++R L L
Sbjct: 1437 DVERTNAACAALDKKQRNFDK---ILAEWKQKCEETHAELEA----SQKEARSLGTELFK 1489
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRA 416
K +++L + ETL L Q ++ L + G L +++ Q+E++ ELQ A
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 417 RQREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEE 465
+ + + +H + ++ VD+ ++E +E + + + +E S +
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD- 1608
Query: 466 IANMKKLQDELLLNKEQLLAEMERMQMEID 495
A ++ D + L K+++ ++ M+++++
Sbjct: 1609 -AEIRSRNDAIRL-KKKMEGDLNEMEIQLN 1636
Score = 66.6 bits (161), Expect = 1e-10
Identities = 96/471 (20%), Positives = 201/471 (42%), Gaps = 74/471 (15%)
Query: 59 RLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE 118
+L L E +LQ+++S L ++ A K ++ + + E+E EL+A LE
Sbjct: 1500 QLETLKRENKNLQQEIS-DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 119 HLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMAL 178
H E + R + L V SEV+ + + E + +D+ R +R+
Sbjct: 1559 HEEGKILRIQLELNQ------------VKSEVD-----RKIAEKDEEIDQLKRNHIRIVE 1601
Query: 179 ERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD---GQTLANGLGPGGDSNRRT 235
+ L+ E+ S + + L++++ + +E + + L N G
Sbjct: 1602 SMQSTLDAEIR-SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 236 AELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT--------------AHRELGKAE 281
L++AL Q L+E+LA++ R+ + L+ E+ A +EL A
Sbjct: 1661 IHLDDALRSQE----DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 282 E--------------ANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDAND 327
E KL+ D+ + + ED+ + E++ A +A + +
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 328 KLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNK 387
K ++ A E + + E+ + L LD+A+Q + +K + ++EA++ + +
Sbjct: 1777 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK--QIQKLEARVRELEGEVES 1834
Query: 388 AEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQL 447
++R+ + LR+ E +++E + + R+ + RL + VDKL +++
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRK-------NILRLQDLVDKL----QAKVKS 1883
Query: 448 HLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
+ ++ A E+ N+ +A +KLQ EL E+ + + ++++LR
Sbjct: 1884 YKRQAEEAEEQSNT---NLAKFRKLQHEL----EEAEERADIAESQVNKLR 1927
Score = 57.8 bits (138), Expect = 6e-08
Identities = 53/231 (22%), Positives = 109/231 (47%), Gaps = 31/231 (13%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQREATSLHDANDKLE 330
+E+ +E K++ +L ++ A+R+++EE++ TL K L Q EA L DA ++ +
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+ +K L + K+++ ++AE EI A+L A K E+
Sbjct: 913 QLIKTKIQL------------------EAKIKEVTERAEDEEEINAEL---TAKKRKLED 951
Query: 391 RHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK 450
++ + LE L + +E + K + L ET+ KL E + H +
Sbjct: 952 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 451 --ERMGALEEK-NSLSEEIANMKKLQDEL---LLNKEQLLAEMERMQMEID 495
+ + A E+K N+L++ +++ D+L L +++L ++ER + +++
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/257 (23%), Positives = 126/257 (49%), Gaps = 46/257 (17%)
Query: 261 RQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQ 316
++M+ ++EE EL K+E A+R+++EE++ TL K L Q
Sbjct: 853 KEMATMKEEFQKIKDELAKSE--------------AKRKELEEKMVTLLKEKNDLQLQVQ 898
Query: 317 REATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD----------AKQKLQ-QTL 365
EA L DA ++ + + +K L E K +++ E +D K+KL+ +
Sbjct: 899 AEAEGLADAEERCDQLIKTKIQL----EAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 366 QKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE---AQLEEKNQELQRARQREKM 422
+ + + ++E LA+ + E + N E + L+ A+L ++ + LQ A Q + +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQ-QTL 1013
Query: 423 NDDHNKRLSETVDKL--LSESNERLQLHLKERMGALEEKNSLSEEIANMK-KLQDELLLN 479
+D L DK+ L+++ +L+ + + G+LE++ L ++ K KL+ +L L
Sbjct: 1014 DD-----LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 480 KEQLLAEMERMQMEIDQ 496
+E ++ ++E + ++D+
Sbjct: 1069 QESIM-DIENEKQQLDE 1084
Score = 45.1 bits (105), Expect = 4e-04
Identities = 79/336 (23%), Positives = 144/336 (42%), Gaps = 59/336 (17%)
Query: 88 ELNLCREQLLEREEEIAELKAERNNTRLLLE----HLE-CLVSRHERSLRMTVVKRQAQS 142
+LN QL AE NT+ +L+ HL+ L S+ + ++ +V+R+A
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVL----------EEELELSN 192
+ +E+E L+A E + + E + L A ERV +L +++LE
Sbjct: 1687 ---LQAEIEELRATLEQTERSRKIAE---QELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 193 QETLNLREQLSRRRSGLEEPGKDG--DGQTLANGLGPGGDSNRRTAELEEALERQRAEVC 250
+ E + + EE K D +A L D++ +++ +E Q +
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME-QTVKDL 1799
Query: 251 QLR----ERLAV---------LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQ 297
QLR E+LA+ L ++ +LE E+ + + +A + K +R +KE Q
Sbjct: 1800 QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859
Query: 298 REDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSR-QLAEWLDD 356
E+ + I L+ D DKL+ ++ S + ++EE+S LA++
Sbjct: 1860 TEEDRKNILRLQ--------------DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF--- 1902
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH 392
+KLQ L++AE +I ++ K+ E H
Sbjct: 1903 --RKLQHELEEAEERADIAESQVNKLRV--KSREVH 1934
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 97.1 bits (240), Expect = 9e-20
Identities = 114/474 (24%), Positives = 217/474 (45%), Gaps = 62/474 (13%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCRE 94
+ T+ + LL+ R+ ++ + + L++ + + +L L Q+ + LT+E NL +E
Sbjct: 837 LFTKVKPLLQVTRQEEE-MQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 894
Query: 95 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLK 154
QL E AE AE RL + E HE R+ + + G + E K
Sbjct: 895 QLQAETELYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKK 947
Query: 155 ALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLEE 211
+ + + + L+E+ R ++ LE+V E +++ E L + +Q LS+ R LEE
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 212 PGKD-----GDGQTLANGLGPGGDSNR-RTAELEEAL---ERQRAEVCQLRERL----AV 258
D + + A L + + +ELE L E+ R E+ +L+ +L +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
Q++ L+ ++ +L K EE L + +AQ+ + ++I LE
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH------- 1119
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
+ D + L++E A++ ++E++ R L E L+ K +L+ TL T E+ A+
Sbjct: 1120 ---ISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
Q V L KA +E R EAQ++E Q+ H + + E ++L
Sbjct: 1173 EQEVTVLKKA------LDEETRSHEAQVQEMRQK-------------HAQAVEELTEQL- 1212
Query: 439 SESNERLQLHLKERMGALEEKNS-LSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
E +R + +L + LE++N+ L+ E+ + + + E+ K++L A+++ +Q
Sbjct: 1213 -EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Score = 94.0 bits (232), Expect = 8e-19
Identities = 106/479 (22%), Positives = 212/479 (44%), Gaps = 22/479 (4%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE+L + + E + + Q +A +++L + E + +L + Q+ AL
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL- 1110
Query: 87 KELNLCREQLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQS 142
K++ + + +E++ +A RN R L E LE L + E +L T +++ ++
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL 202
EV VLK K+L E ++ + +V+E + + V L E+LE + NL
Sbjct: 1171 KR--EQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL---- 1222
Query: 203 SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV---CQLRERL-AV 258
+ + LE+ D LA L G + + ++ LE Q E+ C ER A
Sbjct: 1223 DKNKQTLEKENAD-----LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
L ++ +L+ E+ + L +AE KL +D+ +Q +D +E + ++ L+ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
L + + L+++L + + E L L D+K+KLQ E L E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
+ + L + E ++L + + +L+++ +L ++ + ++ D+LL
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 439 SESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
+E + ER A E + ++ + +E L KE+L + ++ E++ L
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Score = 81.3 bits (199), Expect = 5e-15
Identities = 87/398 (21%), Positives = 168/398 (42%), Gaps = 27/398 (6%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGL-ATAQLRLRELGHEKDSLQRQLSIALPQEFAAL 85
ELE+ + T+ E + L E +D L AT +LR L +L+ Q L
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQN 1587
Query: 86 TKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
++ + QL E E E+ + + +R L + ++ L + + Q+
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQR-----------ALAAAAKKKLEGDLKDLELQADSA 1636
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ---ETLNLREQL 202
+ E +K L+ L K ++ + E A +E + + + + L+E L
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 203 S-----RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRT----AELEEALERQRAEVCQLR 253
+ R+++ LE+ + + +G D RR A+LEE LE ++ + +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 254 ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYL 313
+R+ +Q QL EL T K E A +L+R KE ++ +ME + + K +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 314 SAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPE 373
+A + +++E E K++ + ++K ++L E L + + + Q E +
Sbjct: 1817 AALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 374 IEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
A++ Q L +AEE R+L+ +L+E +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 72.0 bits (175), Expect = 3e-12
Identities = 114/522 (21%), Positives = 218/522 (41%), Gaps = 77/522 (14%)
Query: 23 EAGGELERLMVTM---LTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALP 79
EA LER + T+ L++ ++ L+ + L + R ++ E ++L +Q
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK---EIENLTQQY----- 1408
Query: 80 QEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 139
+E AA +L + +L ++E+ +L + +N R L+ +LE + ++ L
Sbjct: 1409 EEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 140 AQSPGGVSSEVEVLKALKSLFEHHKALDE--KVRERLRMALERVAVLEEELELSNQETLN 197
+ +E E + +AL+E + +E L + + E+L S +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 198 LREQLSRRRSGLEEPGKDGDGQT--LANGLGPGGDSNRRTAELEEALERQRAEVCQLR-- 253
+L + + LE ++ Q L + L D+ R +AL+ Q Q R
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 254 ---ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDM----EERIT 306
E+ L RQ+ + E EL ++ A A KL+ DLK+ Q + EE I
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 307 TLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQ 366
L K L AQ + D +LE+ AS++ ++ ++E ++ A+ L+ +LQ+ L
Sbjct: 1646 QLRK--LQAQ-----MKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLA 1697
Query: 367 KAETL--------PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQ 418
AE E+ +LA ++ N ++ E R+ QLE +LEE+ +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM----- 1752
Query: 419 REKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLL 478
E M+D K A ++ LS E+A + +
Sbjct: 1753 -EAMSDRVRK--------------------------ATQQAEQLSNELATERSTAQKNES 1785
Query: 479 NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQ 520
++QL + + ++ ++ ++ G S + ++ +ALE + +Q
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTI--AALEAKIAQ 1825
Score = 69.3 bits (168), Expect = 2e-11
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 102/606 (16%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
L +E A L EL + + E E + +L+A+ + E +R E + ++ ++
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER--ARAELNDKVHKLQ 1286
Query: 138 RQAQSPGGVSSEVEVLKALK----------SLFEHHKALDEKVRERLRMALERVAVLEEE 187
+ +S G+ +E E KA+K L + + L E+ R++L ++ + + EE
Sbjct: 1287 NEVESVTGMLNEAEG-KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 188 LELSNQ--ETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ 245
L +Q E + ++ L R S L D + D LEE +R
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ--------DFASTVEALEEGKKRF 1397
Query: 246 RAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
+ E+ ++Q EE A+ +L E+ ++LQ++L + + ++ + +
Sbjct: 1398 QKEI-----------ENLTQQYEEKAAAYDKL---EKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 306 TTLEKRY------LSAQREATSLH-DANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
+ LEK+ L+ ++ +S + D D+ E E KE+ ++ +R L E L +AK
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL-EAK 1499
Query: 359 QKLQQTLQ----KAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ 414
++L++T + + E L + + + V L K++ E ++ +++ QLEE ELQ
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELEDELQ 1556
Query: 415 R---ARQREKMN---------------DDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
A+ R ++N D+ N+ + + L E L+ K+R A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 457 EEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEI-DQLRGRPPSSYSRSLPGSALE 515
K L ++ +++ D + +E+ + ++ ++Q ++ D R + SR + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 516 LRYSQAPTLPSG-AHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGEL 574
+A +L + L +A + RA K+ D E+ A
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQA-----------DLEKEELA----------- 1714
Query: 575 DGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
EE A + G L + ++ L+E+LE ++ + + Q+AE+L
Sbjct: 1715 ----EELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 635 ESRVSS 640
+ +++
Sbjct: 1770 SNELAT 1775
Score = 67.0 bits (162), Expect = 1e-10
Identities = 100/491 (20%), Positives = 203/491 (41%), Gaps = 58/491 (11%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
E+ L++ D L R+L + QR+ L +E N+ + ER
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-------QLLAEEKNISSKYADER 1471
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
+ AE + + L LE + E L T +A+ VSS+ +V K + L
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQ 219
+ +AL+ ++ E ++ LE LE+EL+ + L L + + E + D Q
Sbjct: 1531 EKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 220 TLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT------- 272
+ RR +L+ L E+ R++ A+ +LE +L
Sbjct: 1587 N---------EEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 273 -------AHRELGKAEEANSKLQRDLKEALAQREDM-------EERITTLEKRYLSAQRE 318
A ++L K + QR+L++A A R+++ E++ +LE + Q +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 319 ATSLHDAN-------DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETL 371
+ A ++L ELAS S +++ R+L + +++L++ E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRL 430
+ + Q+ L+ + ++ QLE +N+EL+ + + E K
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 431 SETVDKLLSESNERLQLHLKERMGA---LEEKNSLSEEIANMKKLQDELLLNKEQLLAEM 487
++ +++ E+++ +E+ A L++K+ +EI + +++DE + EQ +
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKM-AEQYKEQA 1872
Query: 488 ERMQMEIDQLR 498
E+ + QL+
Sbjct: 1873 EKGNARVKQLK 1883
Score = 64.3 bits (155), Expect = 7e-10
Identities = 67/265 (25%), Positives = 128/265 (48%), Gaps = 35/265 (13%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA-T 320
Q+++ EEE+ EL K +E K + +LKE + + E EK L Q +A T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-----EKNLLQEQLQAET 900
Query: 321 SLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQK-AETLPEIEAQLA 379
L+ +++ LA+K+ + + E +D Q+LQ +K A+ + ++E QL
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQL---EEKNQELQRARQ--REKMND---------D 425
+ AA K + E ++++LE ++ +++N +L + R+ E+++D +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 426 HNKRLSETVDK---LLSESNERLQLHLKERMGALEEKNSLS-------EEIANMK----K 471
K L++ +K ++SE RL+ K R + K L E+IA+++ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQ 496
L+ +L +E+L A + R+ EI Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQ 1105
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/269 (23%), Positives = 110/269 (40%), Gaps = 33/269 (12%)
Query: 46 LREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAE 105
L + Q+ LA A+ ++ EK+ L +L+ +L AL E ++ + EEE+ E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEE 1747
Query: 106 LKAERNNTRLLLEHLECLVSRHER-SLRMTVVKRQAQSPGGVSSEVEVL-KALKS-LFEH 162
E+ N + + + + E+ S + + AQ ++E K L+S L E
Sbjct: 1748 ---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 163 HKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLA 222
A+ K + + ++A LEE++E +E + L ++ L+E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI---------- 1854
Query: 223 NGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEE 282
L D + + +E E+ A V QL+ QLEE A E +
Sbjct: 1855 --LLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QLEE----AEEESQRINA 1898
Query: 283 ANSKLQRDLKEALAQREDMEERITTLEKR 311
KLQR+L EA E M + L+ +
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 97.1 bits (240), Expect = 9e-20
Identities = 114/474 (24%), Positives = 217/474 (45%), Gaps = 62/474 (13%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCRE 94
+ T+ + LL+ R+ ++ + + L++ + + +L L Q+ + LT+E NL +E
Sbjct: 844 LFTKVKPLLQVTRQEEE-MQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 901
Query: 95 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLK 154
QL E AE AE RL + E HE R+ + + G + E K
Sbjct: 902 QLQAETELYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKK 954
Query: 155 ALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLEE 211
+ + + + L+E+ R ++ LE+V E +++ E L + +Q LS+ R LEE
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 212 PGKD-----GDGQTLANGLGPGGDSNR-RTAELEEAL---ERQRAEVCQLRERL----AV 258
D + + A L + + +ELE L E+ R E+ +L+ +L +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
Q++ L+ ++ +L K EE L + +AQ+ + ++I LE
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH------- 1126
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
+ D + L++E A++ ++E++ R L E L+ K +L+ TL T E+ A+
Sbjct: 1127 ---ISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
Q V L KA +E R EAQ++E Q+ H + + E ++L
Sbjct: 1180 EQEVTVLKKA------LDEETRSHEAQVQEMRQK-------------HAQAVEELTEQL- 1219
Query: 439 SESNERLQLHLKERMGALEEKNS-LSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
E +R + +L + LE++N+ L+ E+ + + + E+ K++L A+++ +Q
Sbjct: 1220 -EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Score = 94.0 bits (232), Expect = 8e-19
Identities = 106/479 (22%), Positives = 212/479 (44%), Gaps = 22/479 (4%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE+L + + E + + Q +A +++L + E + +L + Q+ AL
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL- 1117
Query: 87 KELNLCREQLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQS 142
K++ + + +E++ +A RN R L E LE L + E +L T +++ ++
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL 202
EV VLK K+L E ++ + +V+E + + V L E+LE + NL
Sbjct: 1178 KR--EQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL---- 1229
Query: 203 SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV---CQLRERL-AV 258
+ + LE+ D LA L G + + ++ LE Q E+ C ER A
Sbjct: 1230 DKNKQTLEKENAD-----LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
L ++ +L+ E+ + L +AE KL +D+ +Q +D +E + ++ L+ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
L + + L+++L + + E L L D+K+KLQ E L E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
+ + L + E ++L + + +L+++ +L ++ + ++ D+LL
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 439 SESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
+E + ER A E + ++ + +E L KE+L + ++ E++ L
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Score = 81.3 bits (199), Expect = 5e-15
Identities = 87/398 (21%), Positives = 168/398 (42%), Gaps = 27/398 (6%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGL-ATAQLRLRELGHEKDSLQRQLSIALPQEFAAL 85
ELE+ + T+ E + L E +D L AT +LR L +L+ Q L
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQN 1594
Query: 86 TKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
++ + QL E E E+ + + +R L + ++ L + + Q+
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQR-----------ALAAAAKKKLEGDLKDLELQADSA 1643
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ---ETLNLREQL 202
+ E +K L+ L K ++ + E A +E + + + + L+E L
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 203 S-----RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRT----AELEEALERQRAEVCQLR 253
+ R+++ LE+ + + +G D RR A+LEE LE ++ + +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 254 ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYL 313
+R+ +Q QL EL T K E A +L+R KE ++ +ME + + K +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 314 SAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPE 373
+A + +++E E K++ + ++K ++L E L + + + Q E +
Sbjct: 1824 AALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 374 IEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
A++ Q L +AEE R+L+ +L+E +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 72.0 bits (175), Expect = 3e-12
Identities = 114/522 (21%), Positives = 218/522 (41%), Gaps = 77/522 (14%)
Query: 23 EAGGELERLMVTM---LTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALP 79
EA LER + T+ L++ ++ L+ + L + R ++ E ++L +Q
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK---EIENLTQQY----- 1415
Query: 80 QEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 139
+E AA +L + +L ++E+ +L + +N R L+ +LE + ++ L
Sbjct: 1416 EEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 140 AQSPGGVSSEVEVLKALKSLFEHHKALDE--KVRERLRMALERVAVLEEELELSNQETLN 197
+ +E E + +AL+E + +E L + + E+L S +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 198 LREQLSRRRSGLEEPGKDGDGQT--LANGLGPGGDSNRRTAELEEALERQRAEVCQLR-- 253
+L + + LE ++ Q L + L D+ R +AL+ Q Q R
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 254 ---ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDM----EERIT 306
E+ L RQ+ + E EL ++ A A KL+ DLK+ Q + EE I
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 307 TLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQ 366
L K L AQ + D +LE+ AS++ ++ ++E ++ A+ L+ +LQ+ L
Sbjct: 1653 QLRK--LQAQ-----MKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLA 1704
Query: 367 KAETL--------PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQ 418
AE E+ +LA ++ N ++ E R+ QLE +LEE+ +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM----- 1759
Query: 419 REKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLL 478
E M+D K A ++ LS E+A + +
Sbjct: 1760 -EAMSDRVRK--------------------------ATQQAEQLSNELATERSTAQKNES 1792
Query: 479 NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQ 520
++QL + + ++ ++ ++ G S + ++ +ALE + +Q
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTI--AALEAKIAQ 1832
Score = 69.3 bits (168), Expect = 2e-11
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 102/606 (16%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
L +E A L EL + + E E + +L+A+ + E +R E + ++ ++
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER--ARAELNDKVHKLQ 1293
Query: 138 RQAQSPGGVSSEVEVLKALK----------SLFEHHKALDEKVRERLRMALERVAVLEEE 187
+ +S G+ +E E KA+K L + + L E+ R++L ++ + + EE
Sbjct: 1294 NEVESVTGMLNEAEG-KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 188 LELSNQ--ETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ 245
L +Q E + ++ L R S L D + D LEE +R
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ--------DFASTVEALEEGKKRF 1404
Query: 246 RAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
+ E+ ++Q EE A+ +L E+ ++LQ++L + + ++ + +
Sbjct: 1405 QKEI-----------ENLTQQYEEKAAAYDKL---EKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 306 TTLEKRY------LSAQREATSLH-DANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
+ LEK+ L+ ++ +S + D D+ E E KE+ ++ +R L E L +AK
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL-EAK 1506
Query: 359 QKLQQTLQ----KAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ 414
++L++T + + E L + + + V L K++ E ++ +++ QLEE ELQ
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELEDELQ 1563
Query: 415 R---ARQREKMN---------------DDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
A+ R ++N D+ N+ + + L E L+ K+R A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 457 EEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEI-DQLRGRPPSSYSRSLPGSALE 515
K L ++ +++ D + +E+ + ++ ++Q ++ D R + SR + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 516 LRYSQAPTLPSG-AHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGEL 574
+A +L + L +A + RA K+ D E+ A
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQA-----------DLEKEELA----------- 1721
Query: 575 DGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
EE A + G L + ++ L+E+LE ++ + + Q+AE+L
Sbjct: 1722 ----EELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 635 ESRVSS 640
+ +++
Sbjct: 1777 SNELAT 1782
Score = 67.0 bits (162), Expect = 1e-10
Identities = 100/491 (20%), Positives = 203/491 (41%), Gaps = 58/491 (11%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
E+ L++ D L R+L + QR+ L +E N+ + ER
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-------QLLAEEKNISSKYADER 1478
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
+ AE + + L LE + E L T +A+ VSS+ +V K + L
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQ 219
+ +AL+ ++ E ++ LE LE+EL+ + L L + + E + D Q
Sbjct: 1538 EKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 220 TLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT------- 272
+ RR +L+ L E+ R++ A+ +LE +L
Sbjct: 1594 N---------EEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 273 -------AHRELGKAEEANSKLQRDLKEALAQREDM-------EERITTLEKRYLSAQRE 318
A ++L K + QR+L++A A R+++ E++ +LE + Q +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 319 ATSLHDAN-------DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETL 371
+ A ++L ELAS S +++ R+L + +++L++ E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRL 430
+ + Q+ L+ + ++ QLE +N+EL+ + + E K
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 431 SETVDKLLSESNERLQLHLKERMGA---LEEKNSLSEEIANMKKLQDELLLNKEQLLAEM 487
++ +++ E+++ +E+ A L++K+ +EI + +++DE + EQ +
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKM-AEQYKEQA 1879
Query: 488 ERMQMEIDQLR 498
E+ + QL+
Sbjct: 1880 EKGNARVKQLK 1890
Score = 64.3 bits (155), Expect = 7e-10
Identities = 67/265 (25%), Positives = 128/265 (48%), Gaps = 35/265 (13%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA-T 320
Q+++ EEE+ EL K +E K + +LKE + + E EK L Q +A T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-----EKNLLQEQLQAET 907
Query: 321 SLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQK-AETLPEIEAQLA 379
L+ +++ LA+K+ + + E +D Q+LQ +K A+ + ++E QL
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQL---EEKNQELQRARQ--REKMND---------D 425
+ AA K + E ++++LE ++ +++N +L + R+ E+++D +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 426 HNKRLSETVDK---LLSESNERLQLHLKERMGALEEKNSLS-------EEIANMK----K 471
K L++ +K ++SE RL+ K R + K L E+IA+++ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQ 496
L+ +L +E+L A + R+ EI Q
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQ 1112
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/269 (23%), Positives = 110/269 (40%), Gaps = 33/269 (12%)
Query: 46 LREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAE 105
L + Q+ LA A+ ++ EK+ L +L+ +L AL E ++ + EEE+ E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEE 1754
Query: 106 LKAERNNTRLLLEHLECLVSRHER-SLRMTVVKRQAQSPGGVSSEVEVL-KALKS-LFEH 162
E+ N + + + + E+ S + + AQ ++E K L+S L E
Sbjct: 1755 ---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 163 HKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLA 222
A+ K + + ++A LEE++E +E + L ++ L+E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI---------- 1861
Query: 223 NGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEE 282
L D + + +E E+ A V QL+ QLEE A E +
Sbjct: 1862 --LLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QLEE----AEEESQRINA 1905
Query: 283 ANSKLQRDLKEALAQREDMEERITTLEKR 311
KLQR+L EA E M + L+ +
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSK 1934
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 97.1 bits (240), Expect = 9e-20
Identities = 114/474 (24%), Positives = 217/474 (45%), Gaps = 62/474 (13%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCRE 94
+ T+ + LL+ R+ ++ + + L++ + + +L L Q+ + LT+E NL +E
Sbjct: 844 LFTKVKPLLQVTRQEEE-MQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 901
Query: 95 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLK 154
QL E AE AE RL + E HE R+ + + G + E K
Sbjct: 902 QLQAETELYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKK 954
Query: 155 ALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLEE 211
+ + + + L+E+ R ++ LE+V E +++ E L + +Q LS+ R LEE
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 212 PGKD-----GDGQTLANGLGPGGDSNR-RTAELEEAL---ERQRAEVCQLRERL----AV 258
D + + A L + + +ELE L E+ R E+ +L+ +L +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
Q++ L+ ++ +L K EE L + +AQ+ + ++I LE
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH------- 1126
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
+ D + L++E A++ ++E++ R L E L+ K +L+ TL T E+ A+
Sbjct: 1127 ---ISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
Q V L KA +E R EAQ++E Q+ H + + E ++L
Sbjct: 1180 EQEVTVLKKA------LDEETRSHEAQVQEMRQK-------------HAQAVEELTEQL- 1219
Query: 439 SESNERLQLHLKERMGALEEKNS-LSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
E +R + +L + LE++N+ L+ E+ + + + E+ K++L A+++ +Q
Sbjct: 1220 -EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Score = 94.0 bits (232), Expect = 8e-19
Identities = 106/479 (22%), Positives = 212/479 (44%), Gaps = 22/479 (4%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE+L + + E + + Q +A +++L + E + +L + Q+ AL
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL- 1117
Query: 87 KELNLCREQLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQS 142
K++ + + +E++ +A RN R L E LE L + E +L T +++ ++
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL 202
EV VLK K+L E ++ + +V+E + + V L E+LE + NL
Sbjct: 1178 KR--EQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL---- 1229
Query: 203 SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV---CQLRERL-AV 258
+ + LE+ D LA L G + + ++ LE Q E+ C ER A
Sbjct: 1230 DKNKQTLEKENAD-----LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
L ++ +L+ E+ + L +AE KL +D+ +Q +D +E + ++ L+ +
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
L + + L+++L + + E L L D+K+KLQ E L E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
+ + L + E ++L + + +L+++ +L ++ + ++ D+LL
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 439 SESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
+E + ER A E + ++ + +E L KE+L + ++ E++ L
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Score = 81.3 bits (199), Expect = 5e-15
Identities = 87/398 (21%), Positives = 168/398 (42%), Gaps = 27/398 (6%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGL-ATAQLRLRELGHEKDSLQRQLSIALPQEFAAL 85
ELE+ + T+ E + L E +D L AT +LR L +L+ Q L
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQN 1594
Query: 86 TKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
++ + QL E E E+ + + +R L + ++ L + + Q+
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQR-----------ALAAAAKKKLEGDLKDLELQADSA 1643
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ---ETLNLREQL 202
+ E +K L+ L K ++ + E A +E + + + + L+E L
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 203 S-----RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRT----AELEEALERQRAEVCQLR 253
+ R+++ LE+ + + +G D RR A+LEE LE ++ + +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 254 ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYL 313
+R+ +Q QL EL T K E A +L+R KE ++ +ME + + K +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 314 SAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPE 373
+A + +++E E K++ + ++K ++L E L + + + Q E +
Sbjct: 1824 AALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 374 IEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
A++ Q L +AEE R+L+ +L+E +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 72.0 bits (175), Expect = 3e-12
Identities = 114/522 (21%), Positives = 218/522 (41%), Gaps = 77/522 (14%)
Query: 23 EAGGELERLMVTM---LTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALP 79
EA LER + T+ L++ ++ L+ + L + R ++ E ++L +Q
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK---EIENLTQQY----- 1415
Query: 80 QEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 139
+E AA +L + +L ++E+ +L + +N R L+ +LE + ++ L
Sbjct: 1416 EEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 140 AQSPGGVSSEVEVLKALKSLFEHHKALDE--KVRERLRMALERVAVLEEELELSNQETLN 197
+ +E E + +AL+E + +E L + + E+L S +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 198 LREQLSRRRSGLEEPGKDGDGQT--LANGLGPGGDSNRRTAELEEALERQRAEVCQLR-- 253
+L + + LE ++ Q L + L D+ R +AL+ Q Q R
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 254 ---ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDM----EERIT 306
E+ L RQ+ + E EL ++ A A KL+ DLK+ Q + EE I
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 307 TLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQ 366
L K L AQ + D +LE+ AS++ ++ ++E ++ A+ L+ +LQ+ L
Sbjct: 1653 QLRK--LQAQ-----MKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLA 1704
Query: 367 KAETL--------PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQ 418
AE E+ +LA ++ N ++ E R+ QLE +LEE+ +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM----- 1759
Query: 419 REKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLL 478
E M+D K A ++ LS E+A + +
Sbjct: 1760 -EAMSDRVRK--------------------------ATQQAEQLSNELATERSTAQKNES 1792
Query: 479 NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQ 520
++QL + + ++ ++ ++ G S + ++ +ALE + +Q
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTI--AALEAKIAQ 1832
Score = 69.3 bits (168), Expect = 2e-11
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 102/606 (16%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
L +E A L EL + + E E + +L+A+ + E +R E + ++ ++
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER--ARAELNDKVHKLQ 1293
Query: 138 RQAQSPGGVSSEVEVLKALK----------SLFEHHKALDEKVRERLRMALERVAVLEEE 187
+ +S G+ +E E KA+K L + + L E+ R++L ++ + + EE
Sbjct: 1294 NEVESVTGMLNEAEG-KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 188 LELSNQ--ETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ 245
L +Q E + ++ L R S L D + D LEE +R
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ--------DFASTVEALEEGKKRF 1404
Query: 246 RAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
+ E+ ++Q EE A+ +L E+ ++LQ++L + + ++ + +
Sbjct: 1405 QKEI-----------ENLTQQYEEKAAAYDKL---EKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 306 TTLEKRY------LSAQREATSLH-DANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
+ LEK+ L+ ++ +S + D D+ E E KE+ ++ +R L E L +AK
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL-EAK 1506
Query: 359 QKLQQTLQ----KAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ 414
++L++T + + E L + + + V L K++ E ++ +++ QLEE ELQ
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELEDELQ 1563
Query: 415 R---ARQREKMN---------------DDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
A+ R ++N D+ N+ + + L E L+ K+R A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 457 EEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEI-DQLRGRPPSSYSRSLPGSALE 515
K L ++ +++ D + +E+ + ++ ++Q ++ D R + SR + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 516 LRYSQAPTLPSG-AHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGEL 574
+A +L + L +A + RA K+ D E+ A
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQA-----------DLEKEELA----------- 1721
Query: 575 DGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
EE A + G L + ++ L+E+LE ++ + + Q+AE+L
Sbjct: 1722 ----EELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 635 ESRVSS 640
+ +++
Sbjct: 1777 SNELAT 1782
Score = 67.0 bits (162), Expect = 1e-10
Identities = 100/491 (20%), Positives = 203/491 (41%), Gaps = 58/491 (11%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
E+ L++ D L R+L + QR+ L +E N+ + ER
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-------QLLAEEKNISSKYADER 1478
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
+ AE + + L LE + E L T +A+ VSS+ +V K + L
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQ 219
+ +AL+ ++ E ++ LE LE+EL+ + L L + + E + D Q
Sbjct: 1538 EKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 220 TLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT------- 272
+ RR +L+ L E+ R++ A+ +LE +L
Sbjct: 1594 N---------EEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 273 -------AHRELGKAEEANSKLQRDLKEALAQREDM-------EERITTLEKRYLSAQRE 318
A ++L K + QR+L++A A R+++ E++ +LE + Q +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 319 ATSLHDAN-------DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETL 371
+ A ++L ELAS S +++ R+L + +++L++ E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRL 430
+ + Q+ L+ + ++ QLE +N+EL+ + + E K
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 431 SETVDKLLSESNERLQLHLKERMGA---LEEKNSLSEEIANMKKLQDELLLNKEQLLAEM 487
++ +++ E+++ +E+ A L++K+ +EI + +++DE + EQ +
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKM-AEQYKEQA 1879
Query: 488 ERMQMEIDQLR 498
E+ + QL+
Sbjct: 1880 EKGNARVKQLK 1890
Score = 64.3 bits (155), Expect = 7e-10
Identities = 67/265 (25%), Positives = 128/265 (48%), Gaps = 35/265 (13%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA-T 320
Q+++ EEE+ EL K +E K + +LKE + + E EK L Q +A T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-----EKNLLQEQLQAET 907
Query: 321 SLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQK-AETLPEIEAQLA 379
L+ +++ LA+K+ + + E +D Q+LQ +K A+ + ++E QL
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQL---EEKNQELQRARQ--REKMND---------D 425
+ AA K + E ++++LE ++ +++N +L + R+ E+++D +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 426 HNKRLSETVDK---LLSESNERLQLHLKERMGALEEKNSLS-------EEIANMK----K 471
K L++ +K ++SE RL+ K R + K L E+IA+++ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQ 496
L+ +L +E+L A + R+ EI Q
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQ 1112
Score = 56.2 bits (134), Expect = 2e-07
Identities = 70/317 (22%), Positives = 133/317 (41%), Gaps = 24/317 (7%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
+LE + + RE ++ LR+ Q + Q L + +D + A +E
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-----FATAKENEKKA 1689
Query: 87 KELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGV 146
K L L++ +E++A + R L E L L ++ R A
Sbjct: 1690 KSLEA---DLMQLQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKR 1739
Query: 147 SSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSN---QETLNLREQLS 203
E + + L+ E + E + +R+R A ++ L EL Q+ + R+QL
Sbjct: 1740 RLEARIAQ-LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 204 RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ----RAEVCQLRERLAVL 259
R+ L + +G + + A+LEE +E++ +A L+++ L
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
+ Q+E+E A + +AE+ N+++++ LK L + E+ +RI ++ EA
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQ-LKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 320 TSLHDANDKLENELASK 336
T ++A + N L SK
Sbjct: 1918 TESNEAMGREVNALKSK 1934
Score = 51.2 bits (121), Expect = 6e-06
Identities = 66/279 (23%), Positives = 113/279 (40%), Gaps = 33/279 (11%)
Query: 46 LREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAE 105
L + Q+ LA A+ ++ EK+ L +L+ +L AL E ++ + EEE+ E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEE 1754
Query: 106 LKAERNNTRLLLEHLECLVSRHER-SLRMTVVKRQAQSPGGVSSEVEVL-KALKS-LFEH 162
E+ N + + + + E+ S + + AQ ++E K L+S L E
Sbjct: 1755 ---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 163 HKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLA 222
A+ K + + ++A LEE++E +E + L ++ L+E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI---------- 1861
Query: 223 NGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEE 282
L D + + +E E+ A V QL+ QLEE A E +
Sbjct: 1862 --LLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QLEE----AEEESQRINA 1905
Query: 283 ANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATS 321
KLQR+L EA E M + L+ + + TS
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETS 1944
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 97.1 bits (240), Expect = 9e-20
Identities = 114/474 (24%), Positives = 217/474 (45%), Gaps = 62/474 (13%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCRE 94
+ T+ + LL+ R+ ++ + + L++ + + +L L Q+ + LT+E NL +E
Sbjct: 837 LFTKVKPLLQVTRQEEE-MQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQE 894
Query: 95 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLK 154
QL E AE AE RL + E HE R+ + + G + E K
Sbjct: 895 QLQAETELYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKK 947
Query: 155 ALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLEE 211
+ + + + L+E+ R ++ LE+V E +++ E L + +Q LS+ R LEE
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 212 PGKD-----GDGQTLANGLGPGGDSNR-RTAELEEAL---ERQRAEVCQLRERL----AV 258
D + + A L + + +ELE L E+ R E+ +L+ +L +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
Q++ L+ ++ +L K EE L + +AQ+ + ++I LE
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH------- 1119
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
+ D + L++E A++ ++E++ R L E L+ K +L+ TL T E+ A+
Sbjct: 1120 ---ISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
Q V L KA +E R EAQ++E Q+ H + + E ++L
Sbjct: 1173 EQEVTVLKKA------LDEETRSHEAQVQEMRQK-------------HAQAVEELTEQL- 1212
Query: 439 SESNERLQLHLKERMGALEEKNS-LSEEIANMKKLQDELLLNKEQLLAEMERMQ 491
E +R + +L + LE++N+ L+ E+ + + + E+ K++L A+++ +Q
Sbjct: 1213 -EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Score = 94.0 bits (232), Expect = 8e-19
Identities = 106/479 (22%), Positives = 212/479 (44%), Gaps = 22/479 (4%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE+L + + E + + Q +A +++L + E + +L + Q+ AL
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL- 1110
Query: 87 KELNLCREQLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQS 142
K++ + + +E++ +A RN R L E LE L + E +L T +++ ++
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL 202
EV VLK K+L E ++ + +V+E + + V L E+LE + NL
Sbjct: 1171 KR--EQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL---- 1222
Query: 203 SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV---CQLRERL-AV 258
+ + LE+ D LA L G + + ++ LE Q E+ C ER A
Sbjct: 1223 DKNKQTLEKENAD-----LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 259 LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQRE 318
L ++ +L+ E+ + L +AE KL +D+ +Q +D +E + ++ L+ +
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
L + + L+++L + + E L L D+K+KLQ E L E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 379 AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLL 438
+ + L + E ++L + + +L+++ +L ++ + ++ D+LL
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 439 SESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
+E + ER A E + ++ + +E L KE+L + ++ E++ L
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Score = 81.3 bits (199), Expect = 5e-15
Identities = 87/398 (21%), Positives = 168/398 (42%), Gaps = 27/398 (6%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGL-ATAQLRLRELGHEKDSLQRQLSIALPQEFAAL 85
ELE+ + T+ E + L E +D L AT +LR L +L+ Q L
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQN 1587
Query: 86 TKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
++ + QL E E E+ + + +R L + ++ L + + Q+
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQR-----------ALAAAAKKKLEGDLKDLELQADSA 1636
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ---ETLNLREQL 202
+ E +K L+ L K ++ + E A +E + + + + L+E L
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 203 S-----RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRT----AELEEALERQRAEVCQLR 253
+ R+++ LE+ + + +G D RR A+LEE LE ++ + +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 254 ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYL 313
+R+ +Q QL EL T K E A +L+R KE ++ +ME + + K +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 314 SAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPE 373
+A + +++E E K++ + ++K ++L E L + + + Q E +
Sbjct: 1817 AALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 374 IEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
A++ Q L +AEE R+L+ +L+E +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 72.0 bits (175), Expect = 3e-12
Identities = 114/522 (21%), Positives = 218/522 (41%), Gaps = 77/522 (14%)
Query: 23 EAGGELERLMVTM---LTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALP 79
EA LER + T+ L++ ++ L+ + L + R ++ E ++L +Q
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK---EIENLTQQY----- 1408
Query: 80 QEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 139
+E AA +L + +L ++E+ +L + +N R L+ +LE + ++ L
Sbjct: 1409 EEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 140 AQSPGGVSSEVEVLKALKSLFEHHKALDE--KVRERLRMALERVAVLEEELELSNQETLN 197
+ +E E + +AL+E + +E L + + E+L S +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 198 LREQLSRRRSGLEEPGKDGDGQT--LANGLGPGGDSNRRTAELEEALERQRAEVCQLR-- 253
+L + + LE ++ Q L + L D+ R +AL+ Q Q R
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 254 ---ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDM----EERIT 306
E+ L RQ+ + E EL ++ A A KL+ DLK+ Q + EE I
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 307 TLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQ 366
L K L AQ + D +LE+ AS++ ++ ++E ++ A+ L+ +LQ+ L
Sbjct: 1646 QLRK--LQAQ-----MKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLA 1697
Query: 367 KAETL--------PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQ 418
AE E+ +LA ++ N ++ E R+ QLE +LEE+ +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM----- 1752
Query: 419 REKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLL 478
E M+D K A ++ LS E+A + +
Sbjct: 1753 -EAMSDRVRK--------------------------ATQQAEQLSNELATERSTAQKNES 1785
Query: 479 NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQ 520
++QL + + ++ ++ ++ G S + ++ +ALE + +Q
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTI--AALEAKIAQ 1825
Score = 69.3 bits (168), Expect = 2e-11
Identities = 125/606 (20%), Positives = 255/606 (42%), Gaps = 102/606 (16%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
L +E A L EL + + E E + +L+A+ + E +R E + ++ ++
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER--ARAELNDKVHKLQ 1286
Query: 138 RQAQSPGGVSSEVEVLKALK----------SLFEHHKALDEKVRERLRMALERVAVLEEE 187
+ +S G+ +E E KA+K L + + L E+ R++L ++ + + EE
Sbjct: 1287 NEVESVTGMLNEAEG-KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 188 LELSNQ--ETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ 245
L +Q E + ++ L R S L D + D LEE +R
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ--------DFASTVEALEEGKKRF 1397
Query: 246 RAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
+ E+ ++Q EE A+ +L E+ ++LQ++L + + ++ + +
Sbjct: 1398 QKEI-----------ENLTQQYEEKAAAYDKL---EKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 306 TTLEKRY------LSAQREATSLH-DANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
+ LEK+ L+ ++ +S + D D+ E E KE+ ++ +R L E L +AK
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL-EAK 1499
Query: 359 QKLQQTLQ----KAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ 414
++L++T + + E L + + + V L K++ E ++ +++ QLEE ELQ
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELEDELQ 1556
Query: 415 R---ARQREKMN---------------DDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
A+ R ++N D+ N+ + + L E L+ K+R A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 457 EEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEI-DQLRGRPPSSYSRSLPGSALE 515
K L ++ +++ D + +E+ + ++ ++Q ++ D R + SR + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 516 LRYSQAPTLPSG-AHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGEL 574
+A +L + L +A + RA K+ D E+ A
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQA-----------DLEKEELA----------- 1714
Query: 575 DGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
EE A + G L + ++ L+E+LE ++ + + Q+AE+L
Sbjct: 1715 ----EELASSLSGRNALQDE-KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 635 ESRVSS 640
+ +++
Sbjct: 1770 SNELAT 1775
Score = 67.0 bits (162), Expect = 1e-10
Identities = 100/491 (20%), Positives = 203/491 (41%), Gaps = 58/491 (11%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLER 99
E+ L++ D L R+L + QR+ L +E N+ + ER
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-------QLLAEEKNISSKYADER 1471
Query: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
+ AE + + L LE + E L T +A+ VSS+ +V K + L
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQ 219
+ +AL+ ++ E ++ LE LE+EL+ + L L + + E + D Q
Sbjct: 1531 EKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 220 TLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT------- 272
+ RR +L+ L E+ R++ A+ +LE +L
Sbjct: 1587 N---------EEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 273 -------AHRELGKAEEANSKLQRDLKEALAQREDM-------EERITTLEKRYLSAQRE 318
A ++L K + QR+L++A A R+++ E++ +LE + Q +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 319 ATSLHDAN-------DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETL 371
+ A ++L ELAS S +++ R+L + +++L++ E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRL 430
+ + Q+ L+ + ++ QLE +N+EL+ + + E K
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 431 SETVDKLLSESNERLQLHLKERMGA---LEEKNSLSEEIANMKKLQDELLLNKEQLLAEM 487
++ +++ E+++ +E+ A L++K+ +EI + +++DE + EQ +
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI--LLQVEDERKM-AEQYKEQA 1872
Query: 488 ERMQMEIDQLR 498
E+ + QL+
Sbjct: 1873 EKGNARVKQLK 1883
Score = 64.3 bits (155), Expect = 7e-10
Identities = 67/265 (25%), Positives = 128/265 (48%), Gaps = 35/265 (13%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA-T 320
Q+++ EEE+ EL K +E K + +LKE + + E EK L Q +A T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE-----EKNLLQEQLQAET 900
Query: 321 SLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQK-AETLPEIEAQLA 379
L+ +++ LA+K+ + + E +D Q+LQ +K A+ + ++E QL
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQL---EEKNQELQRARQ--REKMND---------D 425
+ AA K + E ++++LE ++ +++N +L + R+ E+++D +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 426 HNKRLSETVDK---LLSESNERLQLHLKERMGALEEKNSLS-------EEIANMK----K 471
K L++ +K ++SE RL+ K R + K L E+IA+++ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQ 496
L+ +L +E+L A + R+ EI Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQ 1105
Score = 56.2 bits (134), Expect = 2e-07
Identities = 70/317 (22%), Positives = 133/317 (41%), Gaps = 24/317 (7%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
+LE + + RE ++ LR+ Q + Q L + +D + A +E
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-----FATAKENEKKA 1682
Query: 87 KELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGV 146
K L L++ +E++A + R L E L L ++ R A
Sbjct: 1683 KSLEA---DLMQLQEDLAAAERARKQADLEKEELA-------EELASSLSGRNALQDEKR 1732
Query: 147 SSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSN---QETLNLREQLS 203
E + + L+ E + E + +R+R A ++ L EL Q+ + R+QL
Sbjct: 1733 RLEARIAQ-LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 204 RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQ----RAEVCQLRERLAVL 259
R+ L + +G + + A+LEE +E++ +A L+++ L
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREA 319
+ Q+E+E A + +AE+ N+++++ LK L + E+ +RI ++ EA
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQ-LKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 320 TSLHDANDKLENELASK 336
T ++A + N L SK
Sbjct: 1911 TESNEAMGREVNALKSK 1927
Score = 51.2 bits (121), Expect = 6e-06
Identities = 66/279 (23%), Positives = 113/279 (40%), Gaps = 33/279 (11%)
Query: 46 LREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAE 105
L + Q+ LA A+ ++ EK+ L +L+ +L AL E ++ + EEE+ E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDEKRRLEARIAQLEEELEE 1747
Query: 106 LKAERNNTRLLLEHLECLVSRHER-SLRMTVVKRQAQSPGGVSSEVEVL-KALKS-LFEH 162
E+ N + + + + E+ S + + AQ ++E K L+S L E
Sbjct: 1748 ---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 163 HKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLA 222
A+ K + + ++A LEE++E +E + L ++ L+E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI---------- 1854
Query: 223 NGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEE 282
L D + + +E E+ A V QL+ QLEE A E +
Sbjct: 1855 --LLQVEDERKMAEQYKEQAEKGNARVKQLKR----------QLEE----AEEESQRINA 1898
Query: 283 ANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATS 321
KLQR+L EA E M + L+ + + TS
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETS 1937
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 96.7 bits (239), Expect = 1e-19
Identities = 121/487 (24%), Positives = 216/487 (44%), Gaps = 64/487 (13%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE MVT+L E+ L ++ D LA A+ R +L K+ +Q + I E A
Sbjct: 875 ELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQL--IKNKIQLEAKIKEVTERAEEE 932
Query: 87 KELNL-CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
+E+N + + E+E +ELK + ++ L L +E E+ VK + G
Sbjct: 933 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAG 987
Query: 146 VSSEVEVL-KALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLNL 198
+ + L K K+L E H + LD+ E L A ++ ++LE S ++ L
Sbjct: 988 LDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKL 1047
Query: 199 REQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV--------- 249
R L R + LE K T+ D +L+E LE++ E+
Sbjct: 1048 RMDLERAKRKLEGDLKLAQESTM--------DMENDKQQLDEKLEKKEFEISNLISKIED 1099
Query: 250 -----CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED---- 300
QL++++ L ++ +L EE+ KAE+ S L R+L+E + E+
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1159
Query: 301 MEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQK 360
++ +KR Q+ L +A L++E A +L ++ + +L E +D+ Q+
Sbjct: 1160 TSAQVELNKKREAEFQKLRRDLEEAT--LQHE-AMVAALRKKHADSMAELGEQIDNL-QR 1215
Query: 361 LQQTLQKAETLPEIEA-QLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQR 419
++Q L+K ++ ++E L+ A++KA+ GN E+ R LE Q+ E + + Q+
Sbjct: 1216 VKQKLEKEKSELKMETDDLSSNAEAISKAK---GNLEKMCRSLEDQVSE--LKTKEEEQQ 1270
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLN 479
+ND L+ RLQ E L+EK++L +++ K+ + +
Sbjct: 1271 RLIND-------------LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE 1317
Query: 480 KEQLLAE 486
+ L E
Sbjct: 1318 LKHQLEE 1324
Score = 78.2 bits (191), Expect = 4e-14
Identities = 113/551 (20%), Positives = 224/551 (40%), Gaps = 74/551 (13%)
Query: 22 DEAGGELE---RLMVTMLTERERLLETLREA--QDGLATAQLR------LRELGHEKDSL 70
+EAGG L E ++L L EA Q A LR + ELG + D+L
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 71 QRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNT-RLLLEHLECLVSRHER 129
QR + Q+ EL + + L E I++ K R L + + L ++ E
Sbjct: 1214 QR-----VKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268
Query: 130 SLRM----TVVKRQAQSPGG-VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVA-- 182
R+ T + + Q+ G S +++ AL S K + E L+ LE
Sbjct: 1269 QQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA 1328
Query: 183 --VLEEELELSNQETLNLREQLSRRRSG---LEEPGKDGDGQTLANGLGPGGDSNRRTAE 237
L L+ S + LREQ + G L+ + + D+ +RT E
Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1388
Query: 238 LEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQ 297
LEEA ++ L +++ + EE + + + E+ +LQ ++++ +
Sbjct: 1389 LEEAKKK--------------LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1434
Query: 298 REDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDA 357
E L+K+ + + + ++ + EL + S+++SR L+ L
Sbjct: 1435 VERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEA-------SQKESRSLSTELFKV 1487
Query: 358 KQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRAR 417
K +++L + ETL L Q ++ L + G L +++ Q+E++ E+Q A
Sbjct: 1488 KNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAAL 1547
Query: 418 QREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEE-KNSLSEE 465
+ + + +H + ++ VD+ ++E +E + + +E +++L E
Sbjct: 1548 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE 1607
Query: 466 IANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLP 525
I + +++ L K+++ ++ M+++++ +R S R +Q
Sbjct: 1608 I----RSRNDALRVKKKMEGDLNEMEIQLNHA--------NRLAAESLRNYRNTQGILKE 1655
Query: 526 SGAHLDPYVAG 536
+ HLD + G
Sbjct: 1656 TQLHLDDALRG 1666
Score = 62.0 bits (149), Expect = 3e-09
Identities = 124/608 (20%), Positives = 240/608 (39%), Gaps = 98/608 (16%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVV 136
+ +EF EL + E EE++ L E+N+ +L ++ + L ER ++
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 137 KRQAQSP-GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQET 195
K Q ++ V+ E + + + K E L+ ++ + + ++E T
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 196 LNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRER 255
N + L+ +GL+E T+A ++ L+E ++ ++ ++
Sbjct: 975 ENKVKNLTEEMAGLDE--------TIAK-------LSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 256 LAVLCRQMSQLEEELGTAHRELGK-------AEEANSKLQRDLKEALAQREDMEERITTL 308
+ +L + ++LE+++ L + E A KL+ DLK A DME L
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 309 EKRYLSAQREATSL-------------------------HDANDKLENELASKESLYRQS 343
+++ + E ++L + +++E E AS+ +Q
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQR 1139
Query: 344 EEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE 403
+ SR+L E + ++ T + E + EA+ + L +A +H LR+
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH 1199
Query: 404 ----AQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEK 459
A+L E+ LQR +Q K+ + ++ ET D LS + E + + G LE+
Sbjct: 1200 ADSMAELGEQIDNLQRVKQ--KLEKEKSELKMETDD--LSSNAEA----ISKAKGNLEKM 1251
Query: 460 -NSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRY 518
SL ++++ +K ++E L A+ R+Q E + YSR L
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGE--------YSRQLD-------- 1295
Query: 519 SQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSD 578
D V+ R+ K+ ++E + E + ++ D
Sbjct: 1296 ----------EKDALVSQLSRS-KQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCD 1344
Query: 579 ------EEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAE 632
EEE EG AEL +A+ + + + +AI + +L +E K+ QR +
Sbjct: 1345 LLREQYEEEQEGK--AELQRALSKANSEVAQWRTKYETDAIQRTEEL-EEAKKKLAQRLQ 1401
Query: 633 ELESRVSS 640
E E V +
Sbjct: 1402 EAEEHVEA 1409
Score = 60.5 bits (145), Expect = 9e-09
Identities = 90/424 (21%), Positives = 174/424 (41%), Gaps = 72/424 (16%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQREATSLHDANDKLE 330
+E+ +E K + +L ++ A+R+++EE++ TL K L Q EA SL DA ++ E
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCE 909
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+ +K L + K+++ ++AE EI A+L A K E+
Sbjct: 910 QLIKNKIQL------------------EAKIKEVTERAEEEEEINAEL---TAKKRKLED 948
Query: 391 RHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKL------------- 437
++ + LE L + +E + K + L ET+ KL
Sbjct: 949 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ 1008
Query: 438 --------------LSESNERLQLHLKERMGALEEKNSLSEEIANMK-KLQDELLL---- 478
L+++ +L+ + + G+LE++ L ++ K KL+ +L L
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 479 ------NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDP 532
+K+QL ++E+ + EI L + + + +++ QA G ++
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQ-LQKKIKELQARIEELGEEIEA 1127
Query: 533 YVAGSGRAGK-RGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGM-FGAEL 590
A +A K R S EE S+ E + A S EL+ E E + + E
Sbjct: 1128 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV----ELNKKREAEFQKLRRDLEE 1183
Query: 591 LSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVS--SSGLDSLGR 648
+ +A V L + + + ++I +Q K+ E+ EL+ SS +++ +
Sbjct: 1184 ATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243
Query: 649 YRSS 652
+ +
Sbjct: 1244 AKGN 1247
Score = 57.4 bits (137), Expect = 8e-08
Identities = 80/401 (19%), Positives = 157/401 (39%), Gaps = 59/401 (14%)
Query: 98 EREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALK 157
E E+E+A +K E T+ L E E + +T++K + V SE +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKM-VTLLKEKNDLQLQVQSEAD------ 899
Query: 158 SLFEHHKALDEKVRERLRMALERVAVLE--EELELSNQETLNLREQLSRRRSGLEEPGKD 215
SL + + ++ ++ ++++ + V E EE E N E + +L S L+ KD
Sbjct: 900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK---KD 956
Query: 216 GDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHR 275
D +LE L + E ++ L +M+ L+E + +
Sbjct: 957 ID-------------------DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSK 997
Query: 276 ELGKAEEANSKLQRDLKEA-------LAQREDMEERITTLEKRYLSAQREATSLHDANDK 328
E +E + + DL+ + +E+++ LE ++ L A K
Sbjct: 998 EKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRK 1057
Query: 329 LENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKA 388
LE +L + E +QL E L+ + ++ + K E +E QL
Sbjct: 1058 LEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQL---------- 1107
Query: 389 EERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLH 448
++++++L+A++EE +E++ R + LS L E +ERL+
Sbjct: 1108 -------QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE----LEEISERLEEA 1156
Query: 449 LKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMER 489
+E E +++ +E L E ++A + +
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK 1197
Score = 55.1 bits (131), Expect = 4e-07
Identities = 106/514 (20%), Positives = 209/514 (40%), Gaps = 68/514 (13%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS-IALPQE-----FAALTKELNLC 92
+++L + L+EA++ + + L K LQ ++ + L E AAL K+
Sbjct: 1393 KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNF 1452
Query: 93 REQLLE----REEEIAELKAERNNTRLLLEHLECLVSRHERSL-RMTVVKRQAQSPGGVS 147
+ L E EE AEL+A + +R L L + + +E SL ++ ++R+ ++
Sbjct: 1453 DKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEI 1512
Query: 148 SEV--EVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRR 205
S++ ++ + K + E K + +E+ + + A+ E E L ++E LR QL
Sbjct: 1513 SDLTEQIAEGGKQIHELEKIKKQVEQEKCEI---QAALEEAEASLEHEEGKILRIQLELN 1569
Query: 206 RSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQ--- 262
+ E K + + L T +E AE+ + L V +
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQL-----KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD 1624
Query: 263 MSQLEEELGTAHR-----------ELGKAEEANSKL------QRDLKEALAQRE------ 299
++++E +L A+R G +E L Q DLKE LA E
Sbjct: 1625 LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLL 1684
Query: 300 --DMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDA 357
++EE TLE+ S + L DA+++++ SL ++ +++ +
Sbjct: 1685 QAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEV 1744
Query: 358 KQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRAR 417
++ +Q++ E + A L K ++ + E + LE +++ L A
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Query: 418 QREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALE-EKNSLSEEIANMKKLQ--- 473
Q + ++L+ ++E G +E E+ +E + ++K +
Sbjct: 1805 QLALKGG--------------KKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRV 1850
Query: 474 DELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSR 507
EL E+ + R+Q +D+L+ + SY R
Sbjct: 1851 KELTYQTEEDRKNVLRLQDLVDKLQAK-VKSYKR 1883
Score = 50.8 bits (120), Expect = 8e-06
Identities = 87/453 (19%), Positives = 183/453 (40%), Gaps = 69/453 (15%)
Query: 34 TMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQ---LSIALPQEFAALTKE-- 88
T+ E + L + + + + +A ++ EL K ++++ + AL + A+L E
Sbjct: 1500 TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEG 1559
Query: 89 --------LNLCREQ----LLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTV- 135
LN + + + E++EEI +LK RN+TR++ E ++ + RS +
Sbjct: 1560 KILRIQLELNQVKSEVDRKIAEKDEEIDQLK--RNHTRVV-ETMQSTLDAEIRSRNDALR 1616
Query: 136 VKRQ-------------------AQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRM 176
VK++ A+S + +LK + + E ++E+L +
Sbjct: 1617 VKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAI 1676
Query: 177 ALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTA 236
R +L+ E+E E EQ R R E+ D + + +
Sbjct: 1677 VERRANLLQAEIE----ELWATLEQTERSRKIAEQELLDASERVQL--------LHTQNT 1724
Query: 237 ELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTA-------HRELGKAEEANSKLQR 289
L ++ +V QL+ + + ++ EE+ A EL K ++ ++ L+R
Sbjct: 1725 SLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1784
Query: 290 DLKEALAQREDMEERITTLEKRYLSA-----QREATSLHDANDKLENELASKESLYRQSE 344
K +D++ R+ E+ L Q+ + + ++ENE +
Sbjct: 1785 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR 1844
Query: 345 EKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEA 404
+ R++ E ++ + L+ + + +++A++ +AEE+ + R+L+
Sbjct: 1845 KHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQH 1904
Query: 405 QLEEKNQ-----ELQRARQREKMNDDHNKRLSE 432
+LEE + E Q + R K + H K +E
Sbjct: 1905 ELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 95.9 bits (237), Expect = 2e-19
Identities = 104/493 (21%), Positives = 228/493 (46%), Gaps = 65/493 (13%)
Query: 36 LTERERLLETLREAQDGLATAQLRLRELGHEKDS----LQRQLSIALPQEFAALTKELNL 91
L+ +E E L++ GL ++++ KD+ LQ +L L +F+ + + +
Sbjct: 447 LSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLE-TLTNQFSDSKQHIEV 505
Query: 92 CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVE 151
+E L +E+ A L+ E + RL LE E ++++ + ++ A+ G + E+
Sbjct: 506 LKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ-----IQDMAEEKGTQAGEIH 560
Query: 152 VLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL---SRRRSG 208
LK + LD K R +V VL++++E NL+EQL ++ S
Sbjct: 561 DLKDM---------LDVKER--------KVNVLQKKIE-------NLQEQLRDKEKQMSS 596
Query: 209 LEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEE 268
L+E K T +++ LEEAL + + +L+E+ R + +E
Sbjct: 597 LKERVKSLQADTT--------NTDTALTTLEEALAEKERTIERLKEQRD---RDEREKQE 645
Query: 269 ELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDK 328
E+ ++L +E S LQ DL E A D++E ++L L +L A ++
Sbjct: 646 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 705
Query: 329 LENELASKESLYRQSEE---KSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAAL 385
+ E ES +++ E ++R E D + ++ + + + +A++ + + L
Sbjct: 706 KKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 765
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKL---LSESN 442
+ E + ++++ +LE Q++++N+++ + +E++ + ++ E + L++S+
Sbjct: 766 KEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS 825
Query: 443 ERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKE-----------QLLAEMERMQ 491
++LQ L+++ +EE E + ++ +L +E +LL ME+++
Sbjct: 826 QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 885
Query: 492 MEIDQLRGRPPSS 504
E++ ++ + S+
Sbjct: 886 QELESMKAKLSST 898
Score = 88.2 bits (217), Expect = 4e-17
Identities = 109/487 (22%), Positives = 224/487 (45%), Gaps = 77/487 (15%)
Query: 34 TMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCR 93
TML ++ + ++ + E + T + +L D +R++++ L ++ L ++L
Sbjct: 536 TMLNKKTKQIQDMAEEK---GTQAGEIHDLKDMLDVKERKVNV-LQKKIENLQEQLRDKE 591
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVL 153
+Q+ +E + L+A+ NT L LE ++ ER+ +E L
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT-------------------IERL 632
Query: 154 KALKSLFEHHKALD-EKVRERLRMALERVAVLEEELELSNQETLNLREQLSR-RRSGLEE 211
K + E K + + ++ L+ E+V++L+ +L L+L+E S SGL++
Sbjct: 633 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 692
Query: 212 PGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERL------AVLCRQMSQ 265
DS +T E+ ALE+++ E ++ +L A+ R +
Sbjct: 693 ------------------DSRLKTLEI--ALEQKKEECLKMESQLKKAHEAALEARASPE 732
Query: 266 LEEELGTAHRELGKAEEANSKLQRD-------LKEALAQREDMEERITTLEKRYLSAQRE 318
+ + + RE+ + ++ +SK Q + LKE ++ D +++I LE++ ++
Sbjct: 733 MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKK 792
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAET-LPEIEAQ 377
AN K + ++ K+S Q E++R+ + L+D+ Q+LQ +L+K + + E+E
Sbjct: 793 V-----ANLKHKEQVEKKKSA--QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 845
Query: 378 L-------AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRL 430
L A+R L + E N E+++ +L +E+ QEL+ + +
Sbjct: 846 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 905
Query: 431 SETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERM 490
+ L +E + L+ L+ + AL ++SE+ AN+ L EL +K++ E+ +
Sbjct: 906 ETHLTNLRAERRKHLEEVLEMKQEAL--LAAISEKDANIALL--ELSSSKKKTQEEVAAL 961
Query: 491 QMEIDQL 497
+ E D+L
Sbjct: 962 KREKDRL 968
Score = 69.3 bits (168), Expect = 2e-11
Identities = 123/499 (24%), Positives = 204/499 (40%), Gaps = 86/499 (17%)
Query: 66 EKDSLQRQLSIALPQEFAALTKELN-LCREQLLEREEE--IAELKAERNNTRLLLEH--- 119
++++ Q++I Q+ + ++LN L ++ R E +AEL E N RL EH
Sbjct: 219 QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL-TEENFQRLHAEHERQ 277
Query: 120 -LECLVSR---HERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLR 175
E + R E LR+ K+ + S ++L+ L+S KA +E R
Sbjct: 278 AKELFLLRKTLEEMELRIETQKQTLNARD--ESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 176 MALERVAV--LEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNR 233
+A + V LE LE +E LRE++ RR + K QT+ S
Sbjct: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395
Query: 234 R-------------------TAELEEALERQRA----------EVCQLRERLAV------ 258
R T E EE +++ +V QL+E L+
Sbjct: 396 RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455
Query: 259 -LCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQR 317
L ++ + L+ E+G +EL + + LQ L+ Q D ++ I L++ + ++
Sbjct: 456 ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 515
Query: 318 EATSLHDANDKLENELASKESLYRQ--------SEEKSRQLAEWLD-----DAKQKLQQT 364
A L D L L KE++ + +EEK Q E D D K++
Sbjct: 516 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 575
Query: 365 LQK-----AETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRAR-- 417
LQK E L + E Q++ + + N + L LE L EK + ++R +
Sbjct: 576 LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ 635
Query: 418 ----QREKMN--DDHNKRLSETVDKL------LSESNERLQLHLKERMGALEEKNSLSEE 465
+REK D++ K L + +K+ LSE L L LKE +L +S ++
Sbjct: 636 RDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL-LDLKEHASSL--ASSGLKK 692
Query: 466 IANMKKLQDELLLNKEQLL 484
+ +K L+ L KE+ L
Sbjct: 693 DSRLKTLEIALEQKKEECL 711
Score = 55.5 bits (132), Expect = 3e-07
Identities = 101/479 (21%), Positives = 196/479 (40%), Gaps = 53/479 (11%)
Query: 45 TLREAQDG-LATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLE----R 99
+LR+A+D + Q +L+E+ E D L++ + + + +++ +L + R
Sbjct: 142 SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
Query: 100 EEEIAELKAERNNTRLLLE---HLECLVSRHERSLRMTVVKRQA--QSPGGVSSEVEVLK 154
++E +++ + R++ E H++ + + LR+ Q Q + E V +
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 155 ALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQ-ETLNLR-EQLSRRRSGLEEP 212
+ F+ A E R+ + L R + E EL + Q +TLN R E + + L+
Sbjct: 262 LTEENFQRLHA--EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 213 GKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT 272
G + + RT L EA V L L ++ S L EE+
Sbjct: 320 GLSAKATE---------EDHERTRRLAEA----EMHVHHLESLLEQKEKENSMLREEM-- 364
Query: 273 AHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHD----ANDK 328
HR A + S + L+ + ++ +I+++E+ + E L + ++
Sbjct: 365 -HRRFENAPD--SAKTKALQTVIEMKDS---KISSMERGLRDLEEEIQMLKSNGALSTEE 418
Query: 329 LENELASKESLYRQ----SEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAA 384
E E+ E +YR + K QL E L + + ++ +KA L +A++ Q
Sbjct: 419 REEEMKQME-VYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL---QAEIGQVKQE 474
Query: 385 LNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKL---LSES 441
L++ + + +L L Q + Q ++ ++ + L VD L L E
Sbjct: 475 LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
Query: 442 NERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGR 500
L K+ EEK + + EI ++K + D L ++E +Q +QLR +
Sbjct: 535 ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ---EQLRDK 590
Score = 53.1 bits (126), Expect = 2e-06
Identities = 90/416 (21%), Positives = 168/416 (40%), Gaps = 37/416 (8%)
Query: 249 VCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKL-QRDLKEALAQREDMEERITT 307
+ L+ +L + R+ L +++ +L + + +LK+ A R+D +IT
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
Query: 308 LEKRYLSAQREATSLHDANDKLENELASKESLYR--QSEEKSRQ----LAEWLDDAKQKL 361
+++Y Q E + L++EL + L + Q + SR +AE ++ Q+L
Sbjct: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 362 QQTLQKA--------ETLPEIEAQLAQRVAALNKAEERHGNFEERLRQ--LEAQLEEKNQ 411
++ +TL E+E ++ + LN +E E L+ L A+ E++
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH 330
Query: 412 ELQRARQREKMNDDHNKRLSETVDK----LLSESNERLQ-----LHLKERMGALEEKNS- 461
E R +M+ H + L E +K L E + R + K +E K+S
Sbjct: 331 ERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSK 390
Query: 462 LSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQA 521
+S ++ L++E+ + K E + E+ Q+ S+S+ + +L+ +
Sbjct: 391 ISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY--RSHSKFMKNKVEQLKEELS 448
Query: 522 PTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPS-KDWERSAPAGSIPPPFPGELDGSDEE 580
L AG + VK+E S KD E A + D
Sbjct: 449 SKEAQWEELKKKAAGL-----QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI 503
Query: 581 EA--EGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
E E + E + Q +V L + L+E+ +NK+ K IQ+ E +A E+
Sbjct: 504 EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 95.5 bits (236), Expect = 3e-19
Identities = 132/510 (25%), Positives = 228/510 (44%), Gaps = 75/510 (14%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE MVT++ E+ L ++ D LA A+ R +L K +Q + I E A
Sbjct: 876 ELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQL--IKTKIQLEAKIKEVTERAEDE 933
Query: 87 KELNL-CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
+E+N + + E+E +ELK + ++ L L +E E+ VK + G
Sbjct: 934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAG 988
Query: 146 VSSEV-EVLKALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLNL 198
+ + ++ K K+L E H + LD+ E L A ++ ++LE S ++ +
Sbjct: 989 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKI 1048
Query: 199 REQLSRRRSGLEEPGK---------DGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV 249
R L R + LE K + D Q L L + L+ +E ++A
Sbjct: 1049 RMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL---KKKEFEMSGLQSKIEDEQALG 1105
Query: 250 CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED----MEERI 305
QL++++ L ++ +LEEE+ KAE+ S L R+L+E + E+ +I
Sbjct: 1106 MQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD---AKQKLQ 362
+KR Q+ L +A L++E A+ +L ++ + +L E +D+ KQKL+
Sbjct: 1166 EMNKKREAEFQKMRRDLEEAT--LQHE-ATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 363 QTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEE---KNQELQRARQR 419
+ +K+E EI+ LA + ++KA+ GN E+ R LE QL E K +E QR
Sbjct: 1223 K--EKSEMKMEID-DLASNMETVSKAK---GNLEKMCRALEDQLSEIKTKEEEQQRL--- 1273
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSL-----------SEEIAN 468
+ND L+ RLQ E L+EK++L +++I
Sbjct: 1274 --IND-------------LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 469 MKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
+K+ +E + K L ++ + + D LR
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLR 1348
Score = 78.6 bits (192), Expect = 3e-14
Identities = 111/496 (22%), Positives = 211/496 (42%), Gaps = 55/496 (11%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSI--ALPQEFAA 84
+LER + + + E+ + ++ +L++ E LQ ++ AL +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQK 1110
Query: 85 LTKELNLCREQLLER--EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQS 142
KEL E+L E E + KAE+ + L E LE + R E + T AQ
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE-LEEISERLEEAGGAT----SAQI 1165
Query: 143 PGGVSSEVEVLKALKSLFE---HHKALDEKVRERLRMALERVAVLEEELELSNQETLNLR 199
E E K + L E H+A +R++ + VA L E+++ + L
Sbjct: 1166 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKK---HADSVAELGEQIDNLQRVKQKLE 1222
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
++ S + +++ + + + A G + + LE+ L + + + + + L
Sbjct: 1223 KEKSEMKMEIDDLASNMETVSKAKG-----NLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 260 CRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITT-LEKRYLSAQRE 318
Q ++L+ E G R+L + + S+L R + Q E+++ ++ ++ + A
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337
Query: 319 ATSLHDAN---DKLENELASKESLYRQSEEKSRQLAEW--------------LDDAKQKL 361
+S HD + ++ E E +K L R + + ++A+W L++AK+KL
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 362 QQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREK 421
Q LQ AE +EA A + A+L K ++R + + L +E N ++++
Sbjct: 1398 AQRLQDAEE--HVEAVNA-KCASLEKTKQR---LQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 422 MNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKE 481
DK+L+E ++ + E + +E SLS E+ +K +E L E
Sbjct: 1452 -----------NFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 482 QLLAEMERMQMEIDQL 497
L E + +Q EI L
Sbjct: 1501 TLKRENKNLQQEISDL 1516
Score = 75.1 bits (183), Expect = 4e-13
Identities = 103/510 (20%), Positives = 210/510 (41%), Gaps = 66/510 (12%)
Query: 22 DEAGGELERLMVTMLTERERLLETLRE------AQDGLATAQLRLR------ELGHEKDS 69
+EAGG + M +RE + +R Q A LR + ELG + D+
Sbjct: 1155 EEAGGATSA-QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1213
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNT-RLLLEHLECLVSRHE 128
LQR + Q+ E+ + + L E +++ K R L + L + ++ E
Sbjct: 1214 LQR-----VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 129 RSLRM----TVVKRQAQSPGG-VSSEVEVLKALKSLFEHHK-ALDEKVRERLRMALERV- 181
R+ T + + Q+ G S +++ L S K A +++ E R E +
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328
Query: 182 --AVLEEELELSNQETLNLREQLSRRRSG---LEEPGKDGDGQTLANGLGPGGDSNRRTA 236
+ L L+ S + LREQ + L+ + + D+ +RT
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 237 ELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALA 296
ELEEA ++ L +++ EE + + + E+ +LQ ++++ +
Sbjct: 1389 ELEEAKKK--------------LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 297 QREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD 356
E L+K+ + + L + K E A E+ S+++SR L+ L
Sbjct: 1435 DVERTNAACAALDKKQRNFDK---ILAEWKQKCEETHAELEA----SQKESRSLSTELFK 1487
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRA 416
K +++L + ETL L Q ++ L + G L +++ Q+E++ ELQ A
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 417 RQREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEE 465
+ + + +H + ++ VD+ ++E +E + + + +E S +
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD- 1606
Query: 466 IANMKKLQDELLLNKEQLLAEMERMQMEID 495
A ++ D + L K+++ ++ M+++++
Sbjct: 1607 -AEIRSRNDAIRL-KKKMEGDLNEMEIQLN 1634
Score = 65.9 bits (159), Expect = 2e-10
Identities = 91/422 (21%), Positives = 174/422 (41%), Gaps = 44/422 (10%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVV 136
+ +EF +EL + E EE++ L E+N+ +L ++ + L ER ++
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 137 KRQAQSP-GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQET 195
K Q ++ V+ E + + + K E L+ ++ + + ++E T
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 975
Query: 196 LNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRER 255
N + L+ +GL+E T+A + + L+ + +V L +
Sbjct: 976 ENKVKNLTEEMAGLDE--------TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 256 LAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSA 315
L +Q+ LE L + E A KL+ DLK A D+E L+++
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 316 QREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIE 375
+ E + L K+E+E ++L Q ++K ++L +++ ++ EIE
Sbjct: 1088 EFEMSGL---QSKIEDE----QALGMQLQKKIKELQARIEELEE-------------EIE 1127
Query: 376 AQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVD 435
A+ A R A E++ L +LEE ++ L+ A + NK+
Sbjct: 1128 AERASRAKA-----------EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 436 KLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEID 495
K+ + E H + L +K+ ++ +A + + D L K++L E M+MEID
Sbjct: 1177 KMRRDLEEATLQH-EATAATLRKKH--ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 496 QL 497
L
Sbjct: 1234 DL 1235
Score = 61.6 bits (148), Expect = 4e-09
Identities = 95/492 (19%), Positives = 202/492 (41%), Gaps = 73/492 (14%)
Query: 34 TMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCR 93
++ TE ++ E+ D L T + + L E L Q++ E EL +
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA-----EGGKRIHELEKIK 1534
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVL 153
+Q+ E+E +EL+A LEH E + R + L V SEV+
Sbjct: 1535 KQV---EQEKSELQAALEEAEASLEHEEGKILRIQLELNQ------------VKSEVD-- 1577
Query: 154 KALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPG 213
+ + E + +D+ R +R+ + L+ E+ S + + L++++ + +E
Sbjct: 1578 ---RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIR-SRNDAIRLKKKMEGDLNEMEIQL 1633
Query: 214 KDGDGQT--------------------LANGLGPGGDSNRRTAELEEALERQRAEVCQLR 253
+ L + L D + A +E +AE+ +LR
Sbjct: 1634 NHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELR 1693
Query: 254 ERLAVLCRQMSQLEEELGTAHRELGKAEEANS-------KLQRDLKEALAQREDMEERIT 306
L R E+EL A + N+ KL+ D+ + + ED+ +
Sbjct: 1694 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEAR 1753
Query: 307 TLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQ 366
E++ A +A + + K ++ A E + + E+ + L LD+A+Q + +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 367 KAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDH 426
K + ++EA++ + + ++R+ + LR+ E +++E + + R+ +
Sbjct: 1814 K--QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK-------N 1864
Query: 427 NKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAE 486
RL + VDKL ++ K + EE+++++ ++ +++Q EL E+
Sbjct: 1865 ILRLQDLVDKLQAKVKS-----YKRQAEEAEEQSNVN--LSKFRRIQHEL----EEAEER 1913
Query: 487 MERMQMEIDQLR 498
+ + ++++LR
Sbjct: 1914 ADIAESQVNKLR 1925
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/231 (22%), Positives = 108/231 (46%), Gaps = 31/231 (13%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQREATSLHDANDKLE 330
+E+ +E K + +L + A+R+++EE++ TL + L Q EA SL DA ++ +
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCD 910
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+ +K L + K+++ ++AE EI A+L A K E+
Sbjct: 911 QLIKTKIQL------------------EAKIKEVTERAEDEEEINAEL---TAKKRKLED 949
Query: 391 RHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK 450
++ + LE L + +E + K + L ET+ KL E + H +
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 451 --ERMGALEEK-NSLSEEIANMKKLQDEL---LLNKEQLLAEMERMQMEID 495
+ + A E+K N+L++ +++ D+L L ++++ ++ER + +++
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Score = 42.0 bits (97), Expect = 0.003
Identities = 76/334 (22%), Positives = 138/334 (41%), Gaps = 55/334 (16%)
Query: 88 ELNLCREQLLEREEEIAELKAERNNTRLLLE----HLE-CLVSRHERSLRMTVVKRQAQS 142
+LN QL AE NT+ +L+ HL+ L S+ + ++ +V+R+A
Sbjct: 1625 DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVL----------EEELELSN 192
+ +E+E L+A E + + E + L A ERV +L +++LE
Sbjct: 1685 ---LQAEIEELRATLEQTERSRKIAE---QELLDASERVQLLHTQNTSLINTKKKLETDI 1738
Query: 193 QETLNLREQLSRRRSGLEEPGKDG--DGQTLANGLGPGGDSNRRTAELEEALER------ 244
+ E + + EE K D +A L D++ +++ LE+
Sbjct: 1739 SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798
Query: 245 ---QRAEVCQLR---ERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQR 298
AE L+ +++ L ++ +LE E+ + + +A + K +R +KE Q
Sbjct: 1799 HRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQT 1858
Query: 299 EDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
E+ + I L+ D DKL+ A +S RQ+EE Q L +
Sbjct: 1859 EEDRKNILRLQ--------------DLVDKLQ---AKVKSYKRQAEEAEEQSNVNLSKFR 1901
Query: 359 QKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH 392
++Q L++AE +I ++ K+ E H
Sbjct: 1902 -RIQHELEEAEERADIAESQVNKLRV--KSREVH 1932
Score = 34.7 bits (78), Expect = 0.56
Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 360 KLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQR 419
K++ L+ AET E ++A K +E E + ++LE ++ QE + +
Sbjct: 839 KIKPLLKSAET----EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEI-ANMKKLQDE 475
+ D E D+L+ ++ +L+ +KE E++ ++ E+ A +KL+DE
Sbjct: 895 VQAEADSLADAEERCDQLI-KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 93.6 bits (231), Expect = 1e-18
Identities = 102/457 (22%), Positives = 202/457 (44%), Gaps = 38/457 (8%)
Query: 40 ERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS---IALPQEFAALTKELNLCREQL 96
E L E E Q+ L + E+ L+R+L I LPQE +E Q+
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQE-----GQV 61
Query: 97 LEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKAL 156
E+E ++ E + + + E V E +R + + Q E +V +
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 157 KSLFEHHKALDEK---VRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPG 213
+ E + E+ VRE+ E+ + E+ ++ +REQ + R E
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQV 180
Query: 214 KDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTA 273
++ +GQ G G+ + E EE + Q ++ + E++ QM + EE++G
Sbjct: 181 REQEGQVREQE-GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239
Query: 274 HRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENEL 333
++ K EE K + +++ Q + EE++ E++ L Q+E T + + E ++
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK-QKEQTEQEEQTGEQEEQM 298
Query: 334 ASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHG 393
+E R+ EE+ R+ E + +++ +Q ++ E + E + Q+ ++ + K EE+ G
Sbjct: 299 REQEEQMREQEEQMREQEEQM---REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 394 NFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERM 453
EE++++ E Q+ + QE Q +Q E+M + + +E+M
Sbjct: 356 EQEEQMQKQEEQV--RKQEEQMRKQEEQMRKQEEQMRKQ-----------------EEQM 396
Query: 454 GALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERM 490
G E+K + E+ M++ ++++ KEQ+ + E M
Sbjct: 397 G--EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 75.9 bits (185), Expect = 2e-13
Identities = 62/326 (19%), Positives = 150/326 (46%), Gaps = 17/326 (5%)
Query: 179 ERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAEL 238
E+ A L+EEL+L E ++ + + LE T L G + ++
Sbjct: 11 EKNAELQEELQLVETEKSEIQLHIKELKRKLE---------TDKIPLPQEGQVREQEGQV 61
Query: 239 EEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRD---LKEAL 295
E + R + Q+RE+ + Q Q+ E+ G + G+ E +++ ++E
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 296 AQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSE----EKSRQLA 351
Q + E ++ E + + + + E ++ +E R+ E E+ Q+
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 352 EWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ 411
E +++ Q ++ + E E Q+ ++ + K EE+ G EE++R+ E Q+ E+ +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 412 ELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
++Q+ ++ + ++ ++ E + + + E+ + LK++ E++ E+ M++
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK-EQTEQEEQTGEQEEQMRE 300
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQL 497
++++ +EQ+ + E+M+ + +Q+
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQM 326
Score = 75.5 bits (184), Expect = 3e-13
Identities = 79/404 (19%), Positives = 187/404 (46%), Gaps = 26/404 (6%)
Query: 101 EEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLF 160
EE+ E AE L+E + + H + L+ + + P E +V + +
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLP----QEGQVREQEGQVR 62
Query: 161 EHHKALDEK---VRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD 217
E + E+ VRE+ E+ + E+ ++ +REQ + R E ++ +
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQE 121
Query: 218 GQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHREL 277
GQ G + ++ E + R + Q+RE+ + Q Q+ E+ G +
Sbjct: 122 GQVREQE----GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 177
Query: 278 GKAEEANSKLQRD---LKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELA 334
G+ E +++ + E Q + EE++ E++ + + + K E ++
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237
Query: 335 SKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGN 394
+E ++ EE+ ++ E + +++ +Q ++ E + E E Q+ ++ + EE+ G
Sbjct: 238 EQEEQVQKQEEQVQKQEEQM---RKQEEQMREQEEQMREQEEQMLKQKEQTEQ-EEQTGE 293
Query: 395 FEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMG 454
EE++R+ E Q+ E+ +++ R++E+ + +++ + +++ + + + KE+M
Sbjct: 294 QEEQMREQEEQMREQEEQM---REQEEQMREQEEQMGKQEEQMWEQKEQMWE--QKEQMW 348
Query: 455 ALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
EE+ + E+ M+K ++++ +EQ+ + E+M+ + +Q+R
Sbjct: 349 KQEEQ--MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMR 390
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 92.8 bits (229), Expect = 2e-18
Identities = 103/507 (20%), Positives = 230/507 (45%), Gaps = 69/507 (13%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS--IALPQEFAA 84
E++ L E E +++ + + ++ ++G K L R+ + +AL +
Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLET 463
Query: 85 LTKE-------LNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
LT + + + +E L +E+ A L+ E + RL LE E ++++ + ++
Sbjct: 464 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ-----IQ 518
Query: 138 RQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLN 197
A+ G + E+ LK + LD K R +V VL++++E N
Sbjct: 519 DMAEEKGTQAGEIHDLKDM---------LDVKER--------KVNVLQKKIE-------N 554
Query: 198 LREQL---SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRE 254
L+EQL ++ S L+E K T +++ LEEAL + + +L+E
Sbjct: 555 LQEQLRDKEKQMSSLKERVKSLQADTT--------NTDTALTTLEEALAEKERTIERLKE 606
Query: 255 RLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLS 314
+ R + +EE+ ++L +E S LQ DL E A D++E ++L L
Sbjct: 607 QRD---RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
Query: 315 AQREATSLHDANDKLENELASKESLYRQSEE---KSRQLAEWLDDAKQKLQQTLQKAETL 371
+L A ++ + E ES +++ E ++R E D + ++ + +
Sbjct: 664 KDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDES 723
Query: 372 PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLS 431
+ +A++ + + L + E + ++++ +LE Q++++N+++ + +E++ + ++
Sbjct: 724 SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQML 783
Query: 432 ETVDKL---LSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKE------- 481
E + L++S+++LQ L+++ +EE E + ++ +L +E
Sbjct: 784 EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE 843
Query: 482 ----QLLAEMERMQMEIDQLRGRPPSS 504
+LL ME+++ E++ ++ + S+
Sbjct: 844 KQVEELLMAMEKVKQELESMKAKLSST 870
Score = 88.2 bits (217), Expect = 4e-17
Identities = 109/487 (22%), Positives = 224/487 (45%), Gaps = 77/487 (15%)
Query: 34 TMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCR 93
TML ++ + ++ + E + T + +L D +R++++ L ++ L ++L
Sbjct: 508 TMLNKKTKQIQDMAEEK---GTQAGEIHDLKDMLDVKERKVNV-LQKKIENLQEQLRDKE 563
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVL 153
+Q+ +E + L+A+ NT L LE ++ ER+ +E L
Sbjct: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT-------------------IERL 604
Query: 154 KALKSLFEHHKALD-EKVRERLRMALERVAVLEEELELSNQETLNLREQLSR-RRSGLEE 211
K + E K + + ++ L+ E+V++L+ +L L+L+E S SGL++
Sbjct: 605 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK 664
Query: 212 PGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERL------AVLCRQMSQ 265
DS +T E+ ALE+++ E ++ +L A+ R +
Sbjct: 665 ------------------DSRLKTLEI--ALEQKKEECLKMESQLKKAHEAALEARASPE 704
Query: 266 LEEELGTAHRELGKAEEANSKLQRD-------LKEALAQREDMEERITTLEKRYLSAQRE 318
+ + + RE+ + ++ +SK Q + LKE ++ D +++I LE++ ++
Sbjct: 705 MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKK 764
Query: 319 ATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAET-LPEIEAQ 377
AN K + ++ K+S Q E++R+ + L+D+ Q+LQ +L+K + + E+E
Sbjct: 765 V-----ANLKHKEQVEKKKSA--QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 817
Query: 378 L-------AQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRL 430
L A+R L + E N E+++ +L +E+ QEL+ + +
Sbjct: 818 LRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 877
Query: 431 SETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERM 490
+ L +E + L+ L+ + AL ++SE+ AN+ L EL +K++ E+ +
Sbjct: 878 ETHLTNLRAERRKHLEEVLEMKQEAL--LAAISEKDANIALL--ELSSSKKKTQEEVAAL 933
Query: 491 QMEIDQL 497
+ E D+L
Sbjct: 934 KREKDRL 940
Score = 71.6 bits (174), Expect = 4e-12
Identities = 117/471 (24%), Positives = 197/471 (41%), Gaps = 58/471 (12%)
Query: 66 EKDSLQRQLSIALPQEFAALTKELN-LCREQLLEREEE--IAELKAERNNTRLLLEH--- 119
++++ Q++I Q+ + ++LN L ++ R E +AEL E N RL EH
Sbjct: 219 QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL-TEENFQRLHAEHERQ 277
Query: 120 -LECLVSR---HERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLR 175
E + R E LR+ K+ + S ++L+ L+S KA +E R
Sbjct: 278 AKELFLLRKTLEEMELRIETQKQTLNARD--ESIKKLLEMLQSKGLSAKATEEDHERTRR 335
Query: 176 MALERVAV--LEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDS-N 232
+A + V LE LE +E LRE++ RR + K QT+ S
Sbjct: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395
Query: 233 RRTAELEEALERQRAEVCQLRERLAVLCRQMSQ-------LEEELGTAHRELGKAEEANS 285
R +LEE ++ ++ E +QM ++ ++G +EL + +
Sbjct: 396 RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELL 455
Query: 286 KLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQ--- 342
LQ L+ Q D ++ I L++ + ++ A L D L L KE++ +
Sbjct: 456 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 515
Query: 343 -----SEEKSRQLAEWLD-----DAKQKLQQTLQK-----AETLPEIEAQLAQRVAALNK 387
+EEK Q E D D K++ LQK E L + E Q++ +
Sbjct: 516 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 575
Query: 388 AEERHGNFEERLRQLEAQLEEKNQELQRAR------QREKMN--DDHNKRLSETVDKL-- 437
+ N + L LE L EK + ++R + +REK D++ K L + +K+
Sbjct: 576 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 635
Query: 438 ----LSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLL 484
LSE L L LKE +L +S ++ + +K L+ L KE+ L
Sbjct: 636 LQGDLSEKEASL-LDLKEHASSL--ASSGLKKDSRLKTLEIALEQKKEECL 683
Score = 48.1 bits (113), Expect = 5e-05
Identities = 87/407 (21%), Positives = 162/407 (39%), Gaps = 47/407 (11%)
Query: 249 VCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKL-QRDLKEALAQREDMEERITT 307
+ L+ +L + R+ L +++ +L + + +LK+ A R+D +IT
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
Query: 308 LEKRYLSAQREATSLHDANDKLENELASKESLYR--QSEEKSRQ----LAEWLDDAKQKL 361
+++Y Q E + L++EL + L + Q + SR +AE ++ Q+L
Sbjct: 211 WKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
Query: 362 QQTLQK--------AETLPEIEAQLAQRVAALNKAEERHGNFEERLRQ--LEAQLEEKNQ 411
++ +TL E+E ++ + LN +E E L+ L A+ E++
Sbjct: 271 HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH 330
Query: 412 ELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
E R +M+ H + L E +K S R ++H + K + + MK
Sbjct: 331 ERTRRLAEAEMHVHHLESLLEQKEK--ENSMLREEMHRRFENAPDSAKTKALQTVIEMK- 387
Query: 472 LQDELLLNKEQLLAEMERMQMEIDQLRGRPP-SSYSRSLPGSALELRYSQAPTLPSGAHL 530
D + + E+ L ++E EI L+ S+ R +E+ S + +
Sbjct: 388 --DSKISSMERGLRDLEE---EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFM------ 436
Query: 531 DPYVAGSGRAGKRGRWSGVKEEPS-KDWERSAPAGSIPPPFPGELDGSDEEEA--EGMFG 587
+ + VK+E S KD E A + D E E +
Sbjct: 437 ------------KNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 484
Query: 588 AELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEEL 634
E + Q +V L + L+E+ +NK+ K IQ+ E +A E+
Sbjct: 485 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 531
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 92.0 bits (227), Expect = 3e-18
Identities = 132/502 (26%), Positives = 227/502 (45%), Gaps = 59/502 (11%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE MVT++ E+ L ++ D LA A+ R +L K +Q + I E A
Sbjct: 876 ELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQL--IKTKIQLEAKIKEVTERAEDE 933
Query: 87 KELNL-CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
+E+N + + E+E +ELK + ++ L L +E E+ VK + G
Sbjct: 934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAG 988
Query: 146 VSSEV-EVLKALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLNL 198
+ + ++ K K+L E H + LD+ E L A ++ ++LE S ++ L
Sbjct: 989 LDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKL 1048
Query: 199 REQLSRRRSGLEEPGK---------DGDGQTLANGLGPGGDSNRRTAELEEALERQRAEV 249
L R + LE K + D Q L L + L+ +E ++A
Sbjct: 1049 CMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKL---KKKEFEMSNLQGKIEDEQALA 1105
Query: 250 CQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED----MEERI 305
QL++++ L ++ +LEEE+ KAE+ S L R+L+E + E+ +I
Sbjct: 1106 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD---AKQKLQ 362
+KR Q+ L ++ L++E A+ +L ++ + +L E +D KQKL+
Sbjct: 1166 EMNKKREAEFQKMRRDLEEST--LQHE-ATAAALRKKHADSVAELGEQIDSLQRVKQKLE 1222
Query: 363 QTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEE---KNQELQRARQR 419
+ +K+E EI LA + ++KA+ NFE+ R LE QL E K +E QR
Sbjct: 1223 K--EKSELKMEIN-DLASNMETVSKAK---ANFEKMCRTLEDQLSEIKTKEEEQQRL--- 1273
Query: 420 EKMNDDHNKRLSETVDKLLSESNE-RLQLHLKERMGA--LEEKNSLSEEIANMKKLQDEL 476
+N+ LS +L +ES E QL K+ M + K + +++I +K+ +E
Sbjct: 1274 --INE-----LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326
Query: 477 LLNKEQLLAEMERMQMEIDQLR 498
K L ++ + + D LR
Sbjct: 1327 TKAKSTLAHALQSARHDCDLLR 1348
Score = 79.3 bits (194), Expect = 2e-14
Identities = 138/667 (20%), Positives = 261/667 (39%), Gaps = 98/667 (14%)
Query: 22 DEAGGELERLMVTMLTERERLLETLRE------AQDGLATAQLRLR------ELGHEKDS 69
+EAGG + M +RE + +R Q A LR + ELG + DS
Sbjct: 1155 EEAGGATSA-QIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS 1213
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAE-RNNTRLLLEHLECLVSRHE 128
LQR + L +E + L E+N L E +++ KA R L + L + ++ E
Sbjct: 1214 LQR-VKQKLEKEKSELKMEIN----DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE 1268
Query: 129 RSLRMTVVKRQAQSP------GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERV- 181
R+ + + AQ G S +++ A+ S K + E L+ LE
Sbjct: 1269 EQQRL-INELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEET 1327
Query: 182 ---AVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANG------LGPGGDSN 232
+ L L+ + + LREQ + E + G + AN D+
Sbjct: 1328 KAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQR---GMSKANSEVAQWRTKYETDAI 1384
Query: 233 RRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLK 292
+RT ELEEA ++ L +++ EE + + + E+ +LQ +++
Sbjct: 1385 QRTEELEEAKKK--------------LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVE 1430
Query: 293 EALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAE 352
+ + E L+K+ + + ++ + EL + S+++SR L+
Sbjct: 1431 DLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEA-------SQKESRSLST 1483
Query: 353 WLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQE 412
L K +++L ETL L Q ++ L + G L +++ QL+ + E
Sbjct: 1484 ELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 413 LQRARQREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEEKNS 461
LQ + + + + +H + ++ +D+ ++E +E L + + +E S
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQS 1603
Query: 462 LSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQA 521
+ A ++ D L + K+++ ++ M+++++ +R + LR +Q
Sbjct: 1604 TLD--AEIRSRNDALRI-KKKMEGDLNEMEIQLNHA--------NRQAAEALRNLRNTQG 1652
Query: 522 PTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEE 581
+ HLD + G +KE+ + R+ ++ EL S E
Sbjct: 1653 ILKDTQLHLDDAIRGQ---------DDLKEQLAMVERRA----NLMQAEVEELRASLERT 1699
Query: 582 AEG--MFGAELLSPSGQAD-VQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRV 638
G M ELL S + + T L + + +I IQ E E Q A E +
Sbjct: 1700 ERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKA 1759
Query: 639 SSSGLDS 645
+ D+
Sbjct: 1760 KKAITDA 1766
Score = 67.0 bits (162), Expect = 1e-10
Identities = 104/488 (21%), Positives = 204/488 (41%), Gaps = 83/488 (17%)
Query: 38 ERERLLETLREAQDGLATAQLRLRELGHEK----DSLQRQLSIALPQEFAALTKELNLCR 93
E + LE ++ L+T +++ E ++L+R+ + L QE + LT+++
Sbjct: 1466 ETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE-NKNLQQEISDLTEQIAEGG 1524
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHE-RSLRMTVVKRQAQSPGGVSSEVEV 152
+ + E E+ +L E++ + LE E + E + LR+ + Q V SE++
Sbjct: 1525 KHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ------VKSEID- 1577
Query: 153 LKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEP 212
+ + E + LD+ R LR+ + L+ E+ S + L +++++ + +E
Sbjct: 1578 ----RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIR-SRNDALRIKKKMEGDLNEMEIQ 1632
Query: 213 GKDGDGQT--------------------LANGLGPGGDSNRRTAELEEALERQRAEVCQL 252
+ Q L + + D + A +E +AEV +L
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEEL 1692
Query: 253 RERLAVLCRQMSQLEEELGTAHRELGKAEEANS-------KLQRDLKEALAQREDMEERI 305
R L R E+EL A + N+ KL+ D+ + + ED+ +
Sbjct: 1693 RASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEA 1752
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAK------- 358
E++ A +A + + K ++ A E + + E+ + L LD+A+
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGG 1812
Query: 359 ----QKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQ 414
QKL+ +++ E+ E+E++ V A+ K +H E R+++L Q EE + +
Sbjct: 1813 KKQIQKLEARVRELES--EVESEQKHNVEAV-KGLRKH---ERRVKELTYQTEEDRKNI- 1865
Query: 415 RARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQD 474
RL + VDKL +++ + ++ A E+ N +A +KLQ
Sbjct: 1866 -------------LRLQDLVDKL----QTKVKAYKRQAEEAEEQSN---VNLAKFRKLQH 1905
Query: 475 ELLLNKEQ 482
EL KE+
Sbjct: 1906 ELEEAKER 1913
Score = 65.1 bits (157), Expect = 4e-10
Identities = 90/422 (21%), Positives = 178/422 (42%), Gaps = 44/422 (10%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVV 136
+ +EF +EL + E EE++ L E+N+ +L ++ + L ER ++
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKT 915
Query: 137 KRQAQSP-GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQET 195
K Q ++ V+ E + + + K E L+ ++ + + ++E T
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 975
Query: 196 LNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRER 255
N + L+ +GL+E T+A + + L+ + +V L +
Sbjct: 976 ENKVKNLTEEMAGLDE--------TIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 256 LAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSA 315
L +Q+ LE L + E A KL+ DLK LAQ M+ T +K+ L+
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK--LAQESTMD---TENDKQQLNE 1082
Query: 316 QREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIE 375
+ + +N L+ ++ +++L Q ++K ++L +++ ++ EIE
Sbjct: 1083 KLKKKEFEMSN--LQGKIEDEQALAIQLQKKIKELQARIEELEE-------------EIE 1127
Query: 376 AQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVD 435
A+ A R A E++ L +LEE ++ L+ A + NK+
Sbjct: 1128 AERASRAKA-----------EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 436 KLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEID 495
K+ + E H + AL +K+ ++ +A + + D L K++L E ++MEI+
Sbjct: 1177 KMRRDLEESTLQH-EATAAALRKKH--ADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 496 QL 497
L
Sbjct: 1234 DL 1235
Score = 60.5 bits (145), Expect = 9e-09
Identities = 83/426 (19%), Positives = 181/426 (42%), Gaps = 76/426 (17%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTLEKR----YLSAQREATSLHDANDKLE 330
+E+ +E K + +L + A+R+++EE++ TL + L Q EA +L DA ++ +
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCD 910
Query: 331 NELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEE 390
+ +K L + K+++ ++AE EI A+L A K E+
Sbjct: 911 QLIKTKIQL------------------EAKIKEVTERAEDEEEINAEL---TAKKRKLED 949
Query: 391 RHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKL------------- 437
++ + LE L + +E + K + L ET+ KL
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 438 --------------LSESNERLQLHLKERMGALEEKNSLSEEIANMK-KLQDELLL---- 478
L+++ +L+ + + G+LE++ L ++ K KL+ +L L
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES 1069
Query: 479 ------NKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDP 532
+K+QL ++++ + E+ L+G+ + ++ +++ QA ++
Sbjct: 1070 TMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQ-LQKKIKELQARIEELEEEIEA 1128
Query: 533 YVAGSGRAGK-RGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELL 591
A +A K R S EE S+ E + A S +++ + + EAE L
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATS------AQIEMNKKREAEFQKMRRDL 1182
Query: 592 SPSGQADVQTLAIMLQEQLEAI---NKEIKLIQEEKETTEQRAEELESRVS--SSGLDSL 646
S T A + ++ +++ ++I +Q K+ E+ EL+ ++ +S ++++
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV 1242
Query: 647 GRYRSS 652
+ +++
Sbjct: 1243 SKAKAN 1248
Score = 57.0 bits (136), Expect = 1e-07
Identities = 100/472 (21%), Positives = 198/472 (41%), Gaps = 69/472 (14%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQRQ---LSIALPQEFAALT----KELNL 91
+++L + L++A++ + + L K LQ + L I + + AA K+ N
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 92 CR---EQLLEREEEIAELKAERNNTRLL--------------LEHLECLVSRHERSLRMT 134
+ E + EE AEL+A + +R L L+HLE L R ++L+
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL-KRENKNLQQE 1512
Query: 135 VVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQE 194
+ Q G + L+ +K +H K+ L+ +LE E LE +
Sbjct: 1513 ISDLTEQIAEG-GKHIHELEKVKKQLDHEKS-------ELQTSLEEA---EASLEHEEGK 1561
Query: 195 TLNLREQLSRRRSGLEEP--GKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQL 252
L ++ +L++ +S ++ KD + L +S + T + E R R + ++
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEI---RSRNDALRI 1618
Query: 253 RERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKE-------ALAQREDMEERI 305
++++ ++++E +L A+R+ +A Q LK+ A+ ++D++E++
Sbjct: 1619 KKKME---GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQL 1675
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
+E+R Q E L + ++ E E + E+ + L L T
Sbjct: 1676 AMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASER----VQLLHTQNTSLINTK 1731
Query: 366 QKAET-LPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMND 424
+K ET + +I+ ++ V AEE+ ++ + EE +E + E+M
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEKA---KKAITDAAMMAEELKKEQDTSAHLERMK- 1787
Query: 425 DHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDEL 476
K + +TV L +E QL LK K + + A +++L+ E+
Sbjct: 1788 ---KNMEQTVKDLQLRLDEAEQLALK------GGKKQIQKLEARVRELESEV 1830
Score = 53.1 bits (126), Expect = 2e-06
Identities = 89/447 (19%), Positives = 185/447 (41%), Gaps = 52/447 (11%)
Query: 28 LERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIA---LPQEFAA 84
L+R + E L E + E + + ++L HEK LQ L A L E
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGK 1561
Query: 85 LTK---ELNLCREQL----LEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 137
+ + ELN + ++ E++EE+ +LK RN+ R++ E ++ + RS R ++
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAEKDEELDQLK--RNHLRVV-ESMQSTLDAEIRS-RNDALR 1617
Query: 138 RQAQSPGGVSS-----------EVEVLKALKS----LFEHHKALDEKVRERLRMALERVA 182
+ + G ++ E L+ L++ L + LD+ +R + + E++A
Sbjct: 1618 IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLK-EQLA 1676
Query: 183 VLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEAL 242
++E L E LR L R E G+ Q L + + + L
Sbjct: 1677 MVERRANLMQAEVEELRASLERT-----ERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 243 ERQRAEVCQLRERLAVLCRQMSQLEEELGTA-------HRELGKAEEANSKLQRDLKEAL 295
++ ++ Q++ + + ++ EE+ A EL K ++ ++ L+R K
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1791
Query: 296 AQREDMEERITTLEKRYLSA-----QREATSLHDANDKLENELASKESLYRQSEEKSRQL 350
+D++ R+ E+ L Q+ + + ++E+E + + R++
Sbjct: 1792 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRV 1851
Query: 351 AEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKN 410
E ++ + L+ + + +++ ++ +AEE+ + R+L+ +LEE
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK 1911
Query: 411 Q-----ELQRARQREKMNDDHNKRLSE 432
+ E Q + R K + H K +SE
Sbjct: 1912 ERADIAESQVNKLRVKSREVHTKVISE 1938
Score = 34.3 bits (77), Expect = 0.73
Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 360 KLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQR 419
K++ L+ AET E ++A K +E E + ++LE ++ QE + +
Sbjct: 839 KIKPLLKSAET----EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEI-ANMKKLQDE 475
+ D E D+L+ ++ +L+ +KE E++ ++ E+ A +KL+DE
Sbjct: 895 VQAEADALADAEERCDQLI-KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 91.7 bits (226), Expect = 4e-18
Identities = 124/479 (25%), Positives = 209/479 (43%), Gaps = 81/479 (16%)
Query: 39 RERLLETLREAQDGLATAQ--LRLRELGHEKDSLQRQLSIALPQEFAALTKEL------- 89
R +LL++LREAQ LA AQ L + K QR+ L +E AL EL
Sbjct: 1131 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR---DLGEELEALRGELEDTLDST 1187
Query: 90 NLCREQLLEREEEIAELKAE-RNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSS 148
N +E +RE+E+ ELK TR+ HE +++ + +R Q+ G ++
Sbjct: 1188 NAQQELRSKREQEVTELKKTLEEETRI-----------HEAAVQ-ELRQRHGQALGELAE 1235
Query: 149 EVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSG 208
++E + K +E + R+ALE V E ELS+ +T + RRR
Sbjct: 1236 QLEQARRGKGAWE-----------KTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLE 1283
Query: 209 LEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEE 268
L+ L G GD R AE E L+R +AE+ + L + +L +
Sbjct: 1284 LQ----------LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1333
Query: 269 ELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDK 328
EL + +L A+E LQ + + LA L R + + EA L + +
Sbjct: 1334 ELSSTEAQLHDAQEL---LQEETRAKLA-----------LGSRVRAMEAEAAGLRE---Q 1376
Query: 329 LENELASKESLYRQSEEKSRQLAEWLDDAKQKLQ--QTLQKAETLPEIEAQ-LAQRVAAL 385
LE E A++E R+ + QL+EW +++ + ++A EA+ L QR+A
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
+ +R E R+L+ +L++ +L++ RQ + ++ D+LL+E +
Sbjct: 1437 TETVDR---LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF----DQLLAEEKAAV 1489
Query: 446 QLHLKERMGALEEKN-------SLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
++ER A E SL+ + ++ ++EL L AE+E + D +
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1548
Score = 71.2 bits (173), Expect = 5e-12
Identities = 125/526 (23%), Positives = 217/526 (41%), Gaps = 67/526 (12%)
Query: 14 RRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSL--- 70
R+ G EAG E R E E L + L E + + + R L E D
Sbjct: 1404 RQEEEAGALEAGEEARRRAAR---EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1460
Query: 71 ---QRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN--------TRLLLEH 119
QRQL L ++ + L + +L EE +AE TR L E
Sbjct: 1461 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1520
Query: 120 LECL--VSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMA 177
E + R R+LR A+ +SS+ +V K++ L E + E+ LR
Sbjct: 1521 QEAREELERQNRALR-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA- 1571
Query: 178 LERVAVLEEELELSNQETLNLREQLSRRRSGLEEP--GKDGDGQTLANGLGPGGDSNRRT 235
+V LE+EL + L L + ++ E G+D G+ L R
Sbjct: 1572 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA----KQLRD 1625
Query: 236 AELEEALERQRAEVC-----QLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRD 290
AE+E ER++ + +L L L QM+ + A ++L K + +L R+
Sbjct: 1626 AEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWRE 1685
Query: 291 LKEALAQREDM-------EERITTLEKRYLSAQREATSLHDAN-------DKLENELASK 336
++E RE++ E+R+ LE L Q E + A D++ +E+A+
Sbjct: 1686 VEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANG 1745
Query: 337 ESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFE 396
E+ RQL L +++L++ +E L + +L +V +L +F
Sbjct: 1746 NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1805
Query: 397 ERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGA 455
+ QLE + QEL+ R + + +K ++ L+++ E+L+ +ER+
Sbjct: 1806 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-- 1863
Query: 456 LEEKNSLSEEIANM--KKLQDELL-LNKEQLLAEMERMQMEIDQLR 498
LS ++ K+L++ +L + +E+ +A+ R Q+E LR
Sbjct: 1864 ------LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1903
Score = 68.2 bits (165), Expect = 5e-11
Identities = 106/436 (24%), Positives = 185/436 (42%), Gaps = 67/436 (15%)
Query: 91 LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM-TVVKRQAQSPGGVSSE 149
L R +R+++ + L+ + N L+ RH + R+ T VK Q V+ +
Sbjct: 826 LARRAFQKRQQQQSALRVMQRNCAAYLK------LRHWQWWRLFTKVKPLLQ----VTRQ 875
Query: 150 VEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEE-LELSNQ---------ETLNLR 199
EVL+A + + L ++ + RVA LEEE L+ Q E R
Sbjct: 876 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 935
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
+L+ R+ LE + + + G+ + +++ +R + + +L L
Sbjct: 936 GRLAARKQELELVVSELEARV--------GEEEECSRQMQTEKKRLQQHIQELEAHLEAE 987
Query: 260 --CRQMSQLEEELGTA-----HRELGKAEEANSKLQRDLK-------EALAQREDMEERI 305
RQ QLE+ A +L E+ NSKL ++ K E +Q + EE++
Sbjct: 988 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1047
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
+L K L + EAT + D D+L E ++ L E+ R+L + ++++ +
Sbjct: 1048 KSLNK--LRLKYEAT-IADMEDRLRKEEKGRQEL----EKLKRRLDGESSELQEQMVEQQ 1100
Query: 366 QKAETLPEIEAQLAQR----VAALNKAEERHG---NFEERLRQLEAQLEEKNQELQRARQ 418
Q+AE E+ AQL ++ AAL +AE+ G + LR+ +A L E ++L+ R
Sbjct: 1101 QRAE---ELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1157
Query: 419 REKMNDDHNKRLSETVDKL-------LSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
+ + L E ++ L L +N + +L K E K +L EE +
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217
Query: 472 LQDELLLNKEQLLAEM 487
EL Q L E+
Sbjct: 1218 AVQELRQRHGQALGEL 1233
Score = 67.0 bits (162), Expect = 1e-10
Identities = 102/464 (21%), Positives = 183/464 (39%), Gaps = 57/464 (12%)
Query: 23 EAGGELERLMVTMLTERERLL-------ETLREAQDGLATAQLRLRELGHEKDSLQRQLS 75
EA ELER + E E LL +++ E + A+ +L + L+ +L+
Sbjct: 1522 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1581
Query: 76 IALPQEFA--ALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 133
A + + L E+ L+ +E E + + +L +E R +R+L +
Sbjct: 1582 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1641
Query: 134 TVVKR--------QAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERV---- 181
K+ +AQ + E +K L+ + K L +V E R + E +
Sbjct: 1642 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET-RTSREEIFSQN 1700
Query: 182 AVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD--GQTLANG-------LGPGGDSN 232
E+ L+ E L L+E+L+ + +D D +ANG L
Sbjct: 1701 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLE 1760
Query: 233 RRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLK 292
R +LEE LE +++ L +R L Q+ L EL KAE +L+R ++
Sbjct: 1761 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1820
Query: 293 EALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAE 352
E + + + K ++A LE++LA E Q + +
Sbjct: 1821 ELRGRLGEEDAGARARHKMTIAA-------------LESKLAQAEEQLEQETRERILSGK 1867
Query: 353 WLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQE 412
+ A+++L++ + + E + QL ++ GN R++QL+ QLEE +E
Sbjct: 1868 LVRRAEKRLKEVVLQVEEERRVADQLRDQL--------EKGNL--RVKQLKRQLEEAEEE 1917
Query: 413 LQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
RA+ + + L + + S + E L + R G L
Sbjct: 1918 ASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNRLRRGPL 1958
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/394 (20%), Positives = 159/394 (40%), Gaps = 51/394 (12%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATS 321
Q+++ +E L +EL K +E + R++ E ++ R+ LE+
Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQQSAREVGE-------LQGRVAQLEEE---------- 913
Query: 322 LHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQR 381
+L +L ++ L ++EE +LA KQ+L+ + E+EA++ +
Sbjct: 914 ----RARLAEQLRAEAELCAEAEETRGRLAA----RKQELELVVS------ELEARVGEE 959
Query: 382 VAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSES 441
+ + ++ +++LEA LE + Q+ Q EK+ + + E LL +
Sbjct: 960 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQ 1018
Query: 442 NERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEME-------RMQMEI 494
N +L K L E +S + E K ++L L E +A+ME + + E+
Sbjct: 1019 NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1078
Query: 495 DQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPS 554
++L+ R S + + ++ G + A RA G G + +
Sbjct: 1079 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG---GARAQLL 1135
Query: 555 KDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAIN 614
K + A E E E AE +++ L L++ L++ N
Sbjct: 1136 KSLREAQAA-------LAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1188
Query: 615 --KEIKLIQEEKETTEQRAEELESRVSSSGLDSL 646
+E++ +E++ T ++ E E+R+ + + L
Sbjct: 1189 AQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1222
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 91.7 bits (226), Expect = 4e-18
Identities = 124/479 (25%), Positives = 209/479 (43%), Gaps = 81/479 (16%)
Query: 39 RERLLETLREAQDGLATAQ--LRLRELGHEKDSLQRQLSIALPQEFAALTKEL------- 89
R +LL++LREAQ LA AQ L + K QR+ L +E AL EL
Sbjct: 1123 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR---DLGEELEALRGELEDTLDST 1179
Query: 90 NLCREQLLEREEEIAELKAE-RNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSS 148
N +E +RE+E+ ELK TR+ HE +++ + +R Q+ G ++
Sbjct: 1180 NAQQELRSKREQEVTELKKTLEEETRI-----------HEAAVQ-ELRQRHGQALGELAE 1227
Query: 149 EVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSG 208
++E + K +E + R+ALE V E ELS+ +T + RRR
Sbjct: 1228 QLEQARRGKGAWE-----------KTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLE 1275
Query: 209 LEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEE 268
L+ L G GD R AE E L+R +AE+ + L + +L +
Sbjct: 1276 LQ----------LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1325
Query: 269 ELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDK 328
EL + +L A+E LQ + + LA L R + + EA L + +
Sbjct: 1326 ELSSTEAQLHDAQEL---LQEETRAKLA-----------LGSRVRAMEAEAAGLRE---Q 1368
Query: 329 LENELASKESLYRQSEEKSRQLAEWLDDAKQKLQ--QTLQKAETLPEIEAQ-LAQRVAAL 385
LE E A++E R+ + QL+EW +++ + ++A EA+ L QR+A
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
+ +R E R+L+ +L++ +L++ RQ + ++ D+LL+E +
Sbjct: 1429 TETVDR---LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF----DQLLAEEKAAV 1481
Query: 446 QLHLKERMGALEEKN-------SLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
++ER A E SL+ + ++ ++EL L AE+E + D +
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1540
Score = 71.2 bits (173), Expect = 5e-12
Identities = 125/526 (23%), Positives = 217/526 (41%), Gaps = 67/526 (12%)
Query: 14 RRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSL--- 70
R+ G EAG E R E E L + L E + + + R L E D
Sbjct: 1396 RQEEEAGALEAGEEARRRAAR---EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1452
Query: 71 ---QRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN--------TRLLLEH 119
QRQL L ++ + L + +L EE +AE TR L E
Sbjct: 1453 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1512
Query: 120 LECL--VSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMA 177
E + R R+LR A+ +SS+ +V K++ L E + E+ LR
Sbjct: 1513 QEAREELERQNRALR-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA- 1563
Query: 178 LERVAVLEEELELSNQETLNLREQLSRRRSGLEEP--GKDGDGQTLANGLGPGGDSNRRT 235
+V LE+EL + L L + ++ E G+D G+ L R
Sbjct: 1564 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA----KQLRD 1617
Query: 236 AELEEALERQRAEVC-----QLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRD 290
AE+E ER++ + +L L L QM+ + A ++L K + +L R+
Sbjct: 1618 AEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWRE 1677
Query: 291 LKEALAQREDM-------EERITTLEKRYLSAQREATSLHDAN-------DKLENELASK 336
++E RE++ E+R+ LE L Q E + A D++ +E+A+
Sbjct: 1678 VEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANG 1737
Query: 337 ESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFE 396
E+ RQL L +++L++ +E L + +L +V +L +F
Sbjct: 1738 NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1797
Query: 397 ERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGA 455
+ QLE + QEL+ R + + +K ++ L+++ E+L+ +ER+
Sbjct: 1798 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-- 1855
Query: 456 LEEKNSLSEEIANM--KKLQDELL-LNKEQLLAEMERMQMEIDQLR 498
LS ++ K+L++ +L + +E+ +A+ R Q+E LR
Sbjct: 1856 ------LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1895
Score = 68.2 bits (165), Expect = 5e-11
Identities = 106/436 (24%), Positives = 185/436 (42%), Gaps = 67/436 (15%)
Query: 91 LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM-TVVKRQAQSPGGVSSE 149
L R +R+++ + L+ + N L+ RH + R+ T VK Q V+ +
Sbjct: 818 LARRAFQKRQQQQSALRVMQRNCAAYLK------LRHWQWWRLFTKVKPLLQ----VTRQ 867
Query: 150 VEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEE-LELSNQ---------ETLNLR 199
EVL+A + + L ++ + RVA LEEE L+ Q E R
Sbjct: 868 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 927
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
+L+ R+ LE + + + G+ + +++ +R + + +L L
Sbjct: 928 GRLAARKQELELVVSELEARV--------GEEEECSRQMQTEKKRLQQHIQELEAHLEAE 979
Query: 260 --CRQMSQLEEELGTA-----HRELGKAEEANSKLQRDLK-------EALAQREDMEERI 305
RQ QLE+ A +L E+ NSKL ++ K E +Q + EE++
Sbjct: 980 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1039
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
+L K L + EAT + D D+L E ++ L E+ R+L + ++++ +
Sbjct: 1040 KSLNK--LRLKYEAT-IADMEDRLRKEEKGRQEL----EKLKRRLDGESSELQEQMVEQQ 1092
Query: 366 QKAETLPEIEAQLAQR----VAALNKAEERHG---NFEERLRQLEAQLEEKNQELQRARQ 418
Q+AE E+ AQL ++ AAL +AE+ G + LR+ +A L E ++L+ R
Sbjct: 1093 QRAE---ELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1149
Query: 419 REKMNDDHNKRLSETVDKL-------LSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
+ + L E ++ L L +N + +L K E K +L EE +
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209
Query: 472 LQDELLLNKEQLLAEM 487
EL Q L E+
Sbjct: 1210 AVQELRQRHGQALGEL 1225
Score = 67.0 bits (162), Expect = 1e-10
Identities = 102/464 (21%), Positives = 183/464 (39%), Gaps = 57/464 (12%)
Query: 23 EAGGELERLMVTMLTERERLL-------ETLREAQDGLATAQLRLRELGHEKDSLQRQLS 75
EA ELER + E E LL +++ E + A+ +L + L+ +L+
Sbjct: 1514 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1573
Query: 76 IALPQEFA--ALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 133
A + + L E+ L+ +E E + + +L +E R +R+L +
Sbjct: 1574 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1633
Query: 134 TVVKR--------QAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERV---- 181
K+ +AQ + E +K L+ + K L +V E R + E +
Sbjct: 1634 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET-RTSREEIFSQN 1692
Query: 182 AVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD--GQTLANG-------LGPGGDSN 232
E+ L+ E L L+E+L+ + +D D +ANG L
Sbjct: 1693 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLE 1752
Query: 233 RRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLK 292
R +LEE LE +++ L +R L Q+ L EL KAE +L+R ++
Sbjct: 1753 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1812
Query: 293 EALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAE 352
E + + + K ++A LE++LA E Q + +
Sbjct: 1813 ELRGRLGEEDAGARARHKMTIAA-------------LESKLAQAEEQLEQETRERILSGK 1859
Query: 353 WLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQE 412
+ A+++L++ + + E + QL ++ GN R++QL+ QLEE +E
Sbjct: 1860 LVRRAEKRLKEVVLQVEEERRVADQLRDQL--------EKGNL--RVKQLKRQLEEAEEE 1909
Query: 413 LQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
RA+ + + L + + S + E L + R G L
Sbjct: 1910 ASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNRLRRGPL 1950
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/394 (20%), Positives = 159/394 (40%), Gaps = 51/394 (12%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATS 321
Q+++ +E L +EL K +E + R++ E ++ R+ LE+
Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQQSAREVGE-------LQGRVAQLEEE---------- 905
Query: 322 LHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQR 381
+L +L ++ L ++EE +LA KQ+L+ + E+EA++ +
Sbjct: 906 ----RARLAEQLRAEAELCAEAEETRGRLAA----RKQELELVVS------ELEARVGEE 951
Query: 382 VAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSES 441
+ + ++ +++LEA LE + Q+ Q EK+ + + E LL +
Sbjct: 952 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQ 1010
Query: 442 NERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEME-------RMQMEI 494
N +L K L E +S + E K ++L L E +A+ME + + E+
Sbjct: 1011 NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1070
Query: 495 DQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPS 554
++L+ R S + + ++ G + A RA G G + +
Sbjct: 1071 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG---GARAQLL 1127
Query: 555 KDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAIN 614
K + A E E E AE +++ L L++ L++ N
Sbjct: 1128 KSLREAQAA-------LAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1180
Query: 615 --KEIKLIQEEKETTEQRAEELESRVSSSGLDSL 646
+E++ +E++ T ++ E E+R+ + + L
Sbjct: 1181 AQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1214
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 91.7 bits (226), Expect = 4e-18
Identities = 124/479 (25%), Positives = 209/479 (43%), Gaps = 81/479 (16%)
Query: 39 RERLLETLREAQDGLATAQ--LRLRELGHEKDSLQRQLSIALPQEFAALTKEL------- 89
R +LL++LREAQ LA AQ L + K QR+ L +E AL EL
Sbjct: 1164 RAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR---DLGEELEALRGELEDTLDST 1220
Query: 90 NLCREQLLEREEEIAELKAE-RNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSS 148
N +E +RE+E+ ELK TR+ HE +++ + +R Q+ G ++
Sbjct: 1221 NAQQELRSKREQEVTELKKTLEEETRI-----------HEAAVQ-ELRQRHGQALGELAE 1268
Query: 149 EVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSG 208
++E + K +E + R+ALE V E ELS+ +T + RRR
Sbjct: 1269 QLEQARRGKGAWE-----------KTRLALE-AEVSELRAELSSLQTARQEGEQRRRRLE 1316
Query: 209 LEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEE 268
L+ L G GD R AE E L+R +AE+ + L + +L +
Sbjct: 1317 LQ----------LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSK 1366
Query: 269 ELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDK 328
EL + +L A+E LQ + + LA L R + + EA L + +
Sbjct: 1367 ELSSTEAQLHDAQEL---LQEETRAKLA-----------LGSRVRAMEAEAAGLRE---Q 1409
Query: 329 LENELASKESLYRQSEEKSRQLAEWLDDAKQKLQ--QTLQKAETLPEIEAQ-LAQRVAAL 385
LE E A++E R+ + QL+EW +++ + ++A EA+ L QR+A
Sbjct: 1410 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1469
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
+ +R E R+L+ +L++ +L++ RQ + ++ D+LL+E +
Sbjct: 1470 TETVDR---LERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKF----DQLLAEEKAAV 1522
Query: 446 QLHLKERMGALEEKN-------SLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
++ER A E SL+ + ++ ++EL L AE+E + D +
Sbjct: 1523 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1581
Score = 71.2 bits (173), Expect = 5e-12
Identities = 125/526 (23%), Positives = 217/526 (41%), Gaps = 67/526 (12%)
Query: 14 RRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSL--- 70
R+ G EAG E R E E L + L E + + + R L E D
Sbjct: 1437 RQEEEAGALEAGEEARRRAAR---EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMD 1493
Query: 71 ---QRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN--------TRLLLEH 119
QRQL L ++ + L + +L EE +AE TR L E
Sbjct: 1494 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1553
Query: 120 LECL--VSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMA 177
E + R R+LR A+ +SS+ +V K++ L E + E+ LR
Sbjct: 1554 QEAREELERQNRALR-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA- 1604
Query: 178 LERVAVLEEELELSNQETLNLREQLSRRRSGLEEP--GKDGDGQTLANGLGPGGDSNRRT 235
+V LE+EL + L L + ++ E G+D G+ L R
Sbjct: 1605 --QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA----KQLRD 1658
Query: 236 AELEEALERQRAEVC-----QLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRD 290
AE+E ER++ + +L L L QM+ + A ++L K + +L R+
Sbjct: 1659 AEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWRE 1718
Query: 291 LKEALAQREDM-------EERITTLEKRYLSAQREATSLHDAN-------DKLENELASK 336
++E RE++ E+R+ LE L Q E + A D++ +E+A+
Sbjct: 1719 VEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANG 1778
Query: 337 ESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFE 396
E+ RQL L +++L++ +E L + +L +V +L +F
Sbjct: 1779 NLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFS 1838
Query: 397 ERLRQLEAQLEEKNQELQ-RARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGA 455
+ QLE + QEL+ R + + +K ++ L+++ E+L+ +ER+
Sbjct: 1839 AKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI-- 1896
Query: 456 LEEKNSLSEEIANM--KKLQDELL-LNKEQLLAEMERMQMEIDQLR 498
LS ++ K+L++ +L + +E+ +A+ R Q+E LR
Sbjct: 1897 ------LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLR 1936
Score = 68.2 bits (165), Expect = 5e-11
Identities = 106/436 (24%), Positives = 185/436 (42%), Gaps = 67/436 (15%)
Query: 91 LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM-TVVKRQAQSPGGVSSE 149
L R +R+++ + L+ + N L+ RH + R+ T VK Q V+ +
Sbjct: 859 LARRAFQKRQQQQSALRVMQRNCAAYLK------LRHWQWWRLFTKVKPLLQ----VTRQ 908
Query: 150 VEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEE-LELSNQ---------ETLNLR 199
EVL+A + + L ++ + RVA LEEE L+ Q E R
Sbjct: 909 DEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR 968
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVL 259
+L+ R+ LE + + + G+ + +++ +R + + +L L
Sbjct: 969 GRLAARKQELELVVSELEARV--------GEEEECSRQMQTEKKRLQQHIQELEAHLEAE 1020
Query: 260 --CRQMSQLEEELGTA-----HRELGKAEEANSKLQRDLK-------EALAQREDMEERI 305
RQ QLE+ A +L E+ NSKL ++ K E +Q + EE++
Sbjct: 1021 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1080
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
+L K L + EAT + D D+L E ++ L E+ R+L + ++++ +
Sbjct: 1081 KSLNK--LRLKYEAT-IADMEDRLRKEEKGRQEL----EKLKRRLDGESSELQEQMVEQQ 1133
Query: 366 QKAETLPEIEAQLAQR----VAALNKAEERHG---NFEERLRQLEAQLEEKNQELQRARQ 418
Q+AE E+ AQL ++ AAL +AE+ G + LR+ +A L E ++L+ R
Sbjct: 1134 QRAE---ELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1190
Query: 419 REKMNDDHNKRLSETVDKL-------LSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
+ + L E ++ L L +N + +L K E K +L EE +
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250
Query: 472 LQDELLLNKEQLLAEM 487
EL Q L E+
Sbjct: 1251 AVQELRQRHGQALGEL 1266
Score = 67.0 bits (162), Expect = 1e-10
Identities = 102/464 (21%), Positives = 183/464 (39%), Gaps = 57/464 (12%)
Query: 23 EAGGELERLMVTMLTERERLL-------ETLREAQDGLATAQLRLRELGHEKDSLQRQLS 75
EA ELER + E E LL +++ E + A+ +L + L+ +L+
Sbjct: 1555 EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELT 1614
Query: 76 IALPQEFA--ALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 133
A + + L E+ L+ +E E + + +L +E R +R+L +
Sbjct: 1615 AAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV 1674
Query: 134 TVVKR--------QAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERV---- 181
K+ +AQ + E +K L+ + K L +V E R + E +
Sbjct: 1675 AARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET-RTSREEIFSQN 1733
Query: 182 AVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGD--GQTLANG-------LGPGGDSN 232
E+ L+ E L L+E+L+ + +D D +ANG L
Sbjct: 1734 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLE 1793
Query: 233 RRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLK 292
R +LEE LE +++ L +R L Q+ L EL KAE +L+R ++
Sbjct: 1794 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1853
Query: 293 EALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAE 352
E + + + K ++A LE++LA E Q + +
Sbjct: 1854 ELRGRLGEEDAGARARHKMTIAA-------------LESKLAQAEEQLEQETRERILSGK 1900
Query: 353 WLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQE 412
+ A+++L++ + + E + QL ++ GN R++QL+ QLEE +E
Sbjct: 1901 LVRRAEKRLKEVVLQVEEERRVADQLRDQL--------EKGNL--RVKQLKRQLEEAEEE 1950
Query: 413 LQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGAL 456
RA+ + + L + + S + E L + R G L
Sbjct: 1951 ASRAQAGRRR---LQRELEDVTESAESMNREVTTLRNRLRRGPL 1991
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/394 (20%), Positives = 159/394 (40%), Gaps = 51/394 (12%)
Query: 262 QMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATS 321
Q+++ +E L +EL K +E + R++ E ++ R+ LE+
Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQQSAREVGE-------LQGRVAQLEEE---------- 946
Query: 322 LHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQR 381
+L +L ++ L ++EE +LA KQ+L+ + E+EA++ +
Sbjct: 947 ----RARLAEQLRAEAELCAEAEETRGRLAA----RKQELELVVS------ELEARVGEE 992
Query: 382 VAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSES 441
+ + ++ +++LEA LE + Q+ Q EK+ + + E LL +
Sbjct: 993 EECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL-QLEKVTTEAKMKKFEEDLLLLEDQ 1051
Query: 442 NERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEME-------RMQMEI 494
N +L K L E +S + E K ++L L E +A+ME + + E+
Sbjct: 1052 NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1111
Query: 495 DQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPS 554
++L+ R S + + ++ G + A RA G G + +
Sbjct: 1112 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG---GARAQLL 1168
Query: 555 KDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAIN 614
K + A E E E AE +++ L L++ L++ N
Sbjct: 1169 KSLREAQAA-------LAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1221
Query: 615 --KEIKLIQEEKETTEQRAEELESRVSSSGLDSL 646
+E++ +E++ T ++ E E+R+ + + L
Sbjct: 1222 AQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1255
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 91.3 bits (225), Expect = 5e-18
Identities = 122/499 (24%), Positives = 230/499 (46%), Gaps = 53/499 (10%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQ---RQLSIALPQEFA 83
ELE MV++L E+ L ++ QD LA A+ R +L K L+ ++++ L E
Sbjct: 872 ELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE-E 930
Query: 84 ALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP 143
+ EL + +L E+E +ELK + ++ L L +E E+ VK +
Sbjct: 931 EMNAELTAKKRKL---EDECSELKRDIDDLELTLAKVE-----KEKHATENKVKNLTEEM 982
Query: 144 GGVSSEV-EVLKALKSLFE-HHKALDEKVRER-----LRMALERVAVLEEELELSNQETL 196
G+ + ++ K K+L E H +ALD+ E L A ++ ++LE S ++
Sbjct: 983 AGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK 1042
Query: 197 NLREQLSRRRSGLEEPGK---------DGDGQTLANGLGPGGDSNRRTAELEEALERQRA 247
+R L R + LE K + D Q L L + L +E ++A
Sbjct: 1043 KVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL---KKKDFELNALNARIEDEQA 1099
Query: 248 EVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED----MEE 303
QL+++L L ++ +LEEEL K E+ S L R+L+E + E+
Sbjct: 1100 LGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSV 1159
Query: 304 RITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQ 363
+I +KR Q+ L +A L++E A+ +L ++ + +L E +D+ Q+++Q
Sbjct: 1160 QIEMNKKREAEFQKMRRDLEEAT--LQHE-ATAAALRKKHADSVAELGEQIDNL-QRVKQ 1215
Query: 364 TLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMN 423
L+K ++ E + +L + + + + N E+ R LE Q+ E + + ++ +N
Sbjct: 1216 KLEKEKS--EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQR--SVN 1271
Query: 424 DDHNKRLSETVDKLLSESNERLQLHLKERMGALEE----KNSLSEEIANMKKLQDELLLN 479
D ++R KL +E+ E L L E+ + + K + ++++ ++K+ +E +
Sbjct: 1272 DLTSQRA-----KLQTENGE-LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKA 1325
Query: 480 KEQLLAEMERMQMEIDQLR 498
K L ++ + + D LR
Sbjct: 1326 KNALAHALQSARHDCDLLR 1344
Score = 85.9 bits (211), Expect = 2e-16
Identities = 115/510 (22%), Positives = 225/510 (44%), Gaps = 49/510 (9%)
Query: 22 DEAGGELER-LMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSI---- 76
D+ G LE+ V M ER + R+ + L Q + +L ++K L +L
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAK-----RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE 1086
Query: 77 -----ALPQEFAALTKELNLCREQLLEREEEIAE-LKAERNNTRLLLEHLECLVSRHERS 130
A ++ AL +L ++L R EE+ E L+AER R +E L +SR
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT-ARAKVEKLRSDLSRELEE 1145
Query: 131 LRMTVVKRQAQSPGGVSSEVEVLKALKSLFEH-HKALDEKV--RERLRMALER-----VA 182
+ +R ++ G S ++E+ K ++ F+ + L+E E AL + VA
Sbjct: 1146 IS----ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1201
Query: 183 VLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEAL 242
L E+++ + L ++ S + L++ + + A + + LE+ +
Sbjct: 1202 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA-----NLEKMCRTLEDQM 1256
Query: 243 ERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDME 302
R++ + + + L Q ++L+ E G R+L + E S+L R Q ED++
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 303 ERITT-LEKRYLSAQREATSLHDAN---DKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
++ ++ + A ++ HD + ++ E E +K L R + + ++A+W +
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 359 QKLQQTLQKAETLPEIEAQLAQRVAALNKAEE----RHGNFEERLRQLEAQLEEKNQELQ 414
+Q+ E L E + +LAQR+ +A E + + E+ +L+ ++E+ +++
Sbjct: 1377 T---DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 415 RARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQD 474
R+ D + DK+L+E ++ + E + +E SLS E+ +K +
Sbjct: 1434 RSNAAAAALDKKQRNF----DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489
Query: 475 ELLLNKEQLLAEMERMQMEIDQLRGRPPSS 504
E L + E E + +Q EI L + SS
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLTEQLGSS 1519
Score = 72.0 bits (175), Expect = 3e-12
Identities = 101/512 (19%), Positives = 212/512 (41%), Gaps = 72/512 (14%)
Query: 22 DEAGGELERLMVTMLTERERLLETLRE------AQDGLATAQLRLR------ELGHEKDS 69
+EAGG + + M +RE + +R Q A LR + ELG + D+
Sbjct: 1151 EEAGGATS-VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRH-- 127
LQR + Q+ E L + + E+I + KA N + LE ++ H
Sbjct: 1210 LQR-----VKQKLEKEKSEFKLELDDVTSNMEQIIKAKA---NLEKMCRTLEDQMNEHRS 1261
Query: 128 -----ERSLR-MTVVKRQAQSPGG-VSSEVEVLKALKSLFEHHKALDEKVRERLRMALER 180
+RS+ +T + + Q+ G +S +++ +AL S K + E L+ LE
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 181 VA----VLEEELELSNQETLNLREQLSRR---RSGLEEPGKDGDGQTLANGLGPGGDSNR 233
L L+ + + LREQ ++ L+ + + D+ +
Sbjct: 1322 EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1381
Query: 234 RTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKE 293
RT ELEEA ++ L +++ + EE + + + E+ +LQ ++++
Sbjct: 1382 RTEELEEAKKK--------------LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 294 ALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEW 353
+ E L+K+ + + ++ ++EL S S++++R L+
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES-------SQKEARSLSTE 1480
Query: 354 LDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQEL 413
L K +++L+ ET L + ++ L + G L ++ QLE + EL
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 414 QRARQREKMNDDHNK-----------RLSETVDKLLSESNERLQLHLKERMGALEEKNSL 462
Q A + + + +H + ++ +++ L+E +E ++ + + L +SL
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME---QAKRNHLRVVDSL 1597
Query: 463 SEEIANMKKLQDELLLNKEQLLAEMERMQMEI 494
+ + ++E L K+++ ++ M++++
Sbjct: 1598 QTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Score = 68.2 bits (165), Expect = 5e-11
Identities = 107/494 (21%), Positives = 216/494 (43%), Gaps = 68/494 (13%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQ------EFAALTKELN-- 90
+++L + L+EA++ + + L K LQ ++ + AAL K+
Sbjct: 1390 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF 1449
Query: 91 --LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLR-MTVVKRQAQSPGGVS 147
+ E + EE +EL++ + R L L L + +E SL + KR+ ++
Sbjct: 1450 DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN----- 1504
Query: 148 SEVEVLKALKSLFEHHKALDEKVRERLRMALERV----AVLEEELELSNQETLNLREQL- 202
+ E+ + L K + E + R ++ E++ A+ E E L ++E LR QL
Sbjct: 1505 LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Query: 203 -SRRRSGLEEPGKDGDG---QTLANGLGPGGDSNRRTAELEEALE---RQRAEVCQLRER 255
++ ++ +E + D Q N L R L+ +L+ R R E +++++
Sbjct: 1565 FNQIKAEIERKLAEKDEEMEQAKRNHL-------RVVDSLQTSLDAETRSRNEALRVKKK 1617
Query: 256 LAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKE-------ALAQREDMEERITTL 308
+ ++++E +L A+R +A++ LQ LK+ A+ +D++E I +
Sbjct: 1618 ME---GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 309 EKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEW-LDDAKQKLQ----Q 363
E+R N+ L+ EL ++ Q+E +SR+LAE L + +++Q Q
Sbjct: 1675 ERR--------------NNLLQAELEELRAVVEQTE-RSRKLAEQELIETSERVQLLHSQ 1719
Query: 364 TLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMN 423
+++A L+Q + +A + N EE+ ++ +EL++ +
Sbjct: 1720 NTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1779
Query: 424 DDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQL 483
+ K + +T+ L +E Q+ LK L++ + E+ N +L+ E N E +
Sbjct: 1780 ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN--ELEAEQKRNAESV 1837
Query: 484 LAEMERMQMEIDQL 497
M + + I +L
Sbjct: 1838 KG-MRKSERRIKEL 1850
Score = 60.8 bits (146), Expect = 7e-09
Identities = 76/296 (25%), Positives = 135/296 (45%), Gaps = 41/296 (13%)
Query: 234 RTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRE--------------LGK 279
++AE E+ + + E +L+E L + +LEE++ + +E L
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 280 AEEA-------NSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENE 332
AEE +L+ +KE + ED EE L + + E + L D LE
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 333 LASKESLYRQSEEKSRQLAE---WLDDAKQKL---QQTLQKA--ETLPEIEAQLAQRVAA 384
LA E +E K + L E LD+ KL ++ LQ+A + L +++A+ +V
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE-EDKVNT 1019
Query: 385 LNKAEERHGNFEERLRQLEAQLE-EKNQELQRARQREKMNDDHNKRLSETVDKLLSESNE 443
L KA+ + E+++ LE LE EK + R + K+ D L T + ++ N+
Sbjct: 1020 LTKAKVK---LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD----LKLTQESIMDLEND 1072
Query: 444 RLQLHLKERMGALE-EKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLR 498
+ Q L ER+ + E N+L+ I + + L +L ++L A +E ++ E++ R
Sbjct: 1073 KQQ--LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAER 1126
Score = 60.1 bits (144), Expect = 1e-08
Identities = 100/490 (20%), Positives = 199/490 (40%), Gaps = 69/490 (14%)
Query: 38 ERERLLETLREAQDGLATAQLRLRELGHEK----DSLQRQLSIALPQEFAALTKELNLCR 93
E + LE+ ++ L+T +L+ E ++ +R+ + L +E + LT++L
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQLGSSG 1520
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHE-RSLRMTVVKRQAQSPGGVSSEVEV 152
+ + E E+ +L+AE+ + LE E + E + LR + Q + +E+E
Sbjct: 1521 KTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ------IKAEIE- 1573
Query: 153 LKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEP 212
+ L E + +++ R LR+ L+ E S E L +++++
Sbjct: 1574 ----RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR-SRNEALRVKKKM---------- 1618
Query: 213 GKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGT 272
+GD + L +NR AE ++ ++ ++ + + +L R L+E +
Sbjct: 1619 --EGDLNEMEIQLS---HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 273 AHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDAN------ 326
R N+ LQ +L+E A E E E+ + LH N
Sbjct: 1674 VERR-------NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726
Query: 327 --------DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQL 378
+L+ E+ R +EEK+++ + DA ++ ++ +T +E
Sbjct: 1727 KKKMDADLSQLQTEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTSAHLERMK 1783
Query: 379 AQRVAALNKAEERHGNFEE--------RLRQLEAQLEEKNQELQRARQREKMNDDHNKRL 430
+ + R E+ +L++LEA++ E EL+ A Q+ R
Sbjct: 1784 KNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE-AEQKRNAESVKGMRK 1842
Query: 431 SETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERM 490
SE K L+ E + +L R+ L +K L ++ K+ +E L++ ++
Sbjct: 1843 SERRIKELTYQTEEDRKNLL-RLQDLVDK--LQLKVKAYKRQAEEAEEQANTNLSKFRKV 1899
Query: 491 QMEIDQLRGR 500
Q E+D+ R
Sbjct: 1900 QHELDEAEER 1909
Score = 59.7 bits (143), Expect = 2e-08
Identities = 77/344 (22%), Positives = 154/344 (44%), Gaps = 30/344 (8%)
Query: 169 KVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPG 228
+++E L + R LEE++ QE +L+ Q+ + L + + D Q + N +
Sbjct: 858 RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD-QLIKNKIQLE 916
Query: 229 GDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQ 288
LE+ E AE+ + +L C ++ + ++L ++ K + A
Sbjct: 917 AKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV 975
Query: 289 RDLKEALAQREDMEERITTLEKRYLSAQREATS-LHDANDKLENELASKESLYRQ----- 342
++L E +A +++ ++T +K A ++A L DK+ +K L +Q
Sbjct: 976 KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 343 -SEEKSRQLAEWLDDAKQKLQQTLQKA-ETLPEIE---AQLAQRVA-------ALNKAEE 390
S E+ +++ L+ AK+KL+ L+ E++ ++E QL +R+ ALN E
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 391 RH----GNFEERLRQLEAQLEEKNQELQRARQ-REKMNDDHNKRLSETVDKLLSESNERL 445
+++L++L+A++EE +EL+ R R K+ ++L + + L E +ERL
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKV-----EKLRSDLSRELEEISERL 1150
Query: 446 QLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMER 489
+ +E E M++ +E L E A + +
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1194
Score = 50.8 bits (120), Expect = 8e-06
Identities = 94/443 (21%), Positives = 187/443 (42%), Gaps = 70/443 (15%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
ELE++ + E+ L L EA+ L HE+ + R EF +
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLE----------HEEGKILRA-----QLEFNQIK 1569
Query: 87 KELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTV-VKRQAQSPGG 145
E+ +L E++EE+ + A+RN+ R++ + L+ + RS + VK++ + G
Sbjct: 1570 AEIE---RKLAEKDEEMEQ--AKRNHLRVV-DSLQTSLDAETRSRNEALRVKKKME---G 1620
Query: 146 VSSEVEV---------------LKALKSLFEHHKA-LDEKVRERLRMALERVAVLEEELE 189
+E+E+ +K+L+SL + + LD+ VR + E +A++E
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK-ENIAIVERRNN 1679
Query: 190 LSNQETLNLR---EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQR 246
L E LR EQ R R E+ + + + + L ++
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQL--------LHSQNTSLINQKKKMD 1731
Query: 247 AEVCQLRERLAVLCRQMSQLEEELGTA-------HRELGKAEEANSKLQRDLKEALAQRE 299
A++ QL+ + ++ EE+ A EL K ++ ++ L+R K +
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791
Query: 300 DMEERITTLEKRYLSA-QREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
D++ R+ E+ L +++ L +LENEL +++ +S + R+ + +
Sbjct: 1792 DLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1851
Query: 359 QKLQQTLQKAETLPEIEAQLAQRVAALNK----AEERHGNFEERLRQLEAQLEEKNQ--- 411
+ ++ + L ++ +L +V A + AEE+ + R+++ +L+E +
Sbjct: 1852 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911
Query: 412 --ELQRARQREKMNDDHNKRLSE 432
E Q + R K D K L+E
Sbjct: 1912 IAESQVNKLRAKSRDIGTKGLNE 1934
Score = 40.4 bits (93), Expect = 0.010
Identities = 76/370 (20%), Positives = 148/370 (40%), Gaps = 53/370 (14%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLE 98
R L ++ + L +++L Q+Q+ + +L K+ + + +
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV-----KSLQSLLKDTQIQLDDAVR 1662
Query: 99 REEEIAELKA--ERNNTRLL--LEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLK 154
+++ E A ER N L LE L +V + ERS ++ Q S V++L
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA-----EQELIETSERVQLLH 1717
Query: 155 ALK-SLFEHHKALD---EKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRR--SG 208
+ SL K +D +++ + A++ EE+ + + + + E+L + + S
Sbjct: 1718 SQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1777
Query: 209 LEEPGKDGDGQTLANGLGPGGDSNRRTAELEE-ALERQRAEVCQLRERLAVLCRQMSQLE 267
E K QT+ D R E E+ AL+ + ++ +L R+ +LE
Sbjct: 1778 HLERMKKNMEQTIK-------DLQHRLDEAEQIALKGGKKQLQKLEARVR-------ELE 1823
Query: 268 EELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDAND 327
EL + ++ + K +R +KE Q E+ + + L+ D D
Sbjct: 1824 NELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ--------------DLVD 1869
Query: 328 KLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNK 387
KL+ K Y++ E++ + A +K+Q L +AE +I ++ A ++
Sbjct: 1870 KLQ----LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
Query: 388 AEERHGNFEE 397
G EE
Sbjct: 1926 DIGTKGLNEE 1935
Score = 38.9 bits (89), Expect = 0.030
Identities = 31/137 (22%), Positives = 65/137 (47%), Gaps = 18/137 (13%)
Query: 361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRE 420
L ++ ++ + + ++ + + AL K+E R EE++ L L+EKN +LQ Q E
Sbjct: 839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL---LQEKN-DLQLQVQAE 894
Query: 421 KMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNK 480
+ N L+++ ER +K ++ + ++E + + +++ EL K
Sbjct: 895 QDN--------------LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Query: 481 EQLLAEMERMQMEIDQL 497
+L E ++ +ID L
Sbjct: 941 RKLEDECSELKRDIDDL 957
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 90.5 bits (223), Expect = 9e-18
Identities = 115/474 (24%), Positives = 205/474 (43%), Gaps = 68/474 (14%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS--IALPQEFAA 84
ELE +VT++ E+ L ++ + L A+ R +L K L+ ++ ++
Sbjct: 873 ELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE 932
Query: 85 LTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPG 144
+ EL + +L E+E +ELK + ++ L L +E E+ VK +
Sbjct: 933 INAELTAKKRKL---EDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEELS 984
Query: 145 GVSSEVEVLKALKSLFE--HHKALDEKVRER-----LRMALERVAVLEEELELSNQETLN 197
G+ + L K + H +ALD+ E L ++ E+LE S ++
Sbjct: 985 GLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKK 1044
Query: 198 LREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQL----- 252
LR L R + LE K L D +L+E L+++ E CQL
Sbjct: 1045 LRVDLERNKRKLEGDLKLAQESIL--------DLENDKQQLDERLKKKDFEYCQLQSKVE 1096
Query: 253 ---------RERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEE 303
++++ L ++ +LEEE+ K E+ S R+L+E L++R +
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEE-LSERLEEAG 1155
Query: 304 RITTLEKRYLSAQREATSLHDANDKLENEL---ASKESLYRQSEEKSRQLAEWLDDAKQK 360
+T+ + L+ +REA L D E L A +L ++ + +L E +D+ Q+
Sbjct: 1156 GVTSTQIE-LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNL-QR 1213
Query: 361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEE---KNQELQRAR 417
++Q L+K ++ E + ++ +++ + N E+ R LE QL E KN+E+QR+
Sbjct: 1214 VKQKLEKEKS--EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRS- 1270
Query: 418 QREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKK 471
LSE L+ RLQ E LEEK S+ +++ K+
Sbjct: 1271 ------------LSE-----LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Score = 88.2 bits (217), Expect = 4e-17
Identities = 110/498 (22%), Positives = 215/498 (43%), Gaps = 56/498 (11%)
Query: 29 ERLMVTMLTERERLLETLREAQDGLATAQL-------RLRELGHEKDSLQRQLSI--ALP 79
++L V + + +L L+ AQ+ + + RL++ E LQ ++ L
Sbjct: 1043 KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG 1102
Query: 80 QEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 139
+F KEL E+L EEEI +A R T R + + + + +
Sbjct: 1103 LQFQKKIKELQARIEEL---EEEIEAERATRAKTEK---------QRSDYARELEELSER 1150
Query: 140 AQSPGGVSS---------EVEVLKALKSLFE---HHKALDEKVRERLRMALERVAVLEEE 187
+ GGV+S E E LK + L E H+A+ +R++ + VA L E+
Sbjct: 1151 LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK---HADSVAELGEQ 1207
Query: 188 LELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRA 247
++ + L ++ S + +++ + + + + + LE+ L R
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA-----NLEKICRTLEDQLSEARG 1262
Query: 248 EVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITT 307
+ +++ L+ L Q S+L+ E G R+L + E S+L R + Q E+++ ++
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Query: 308 LEK-RYLSAQREATSLHDAN---DKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQ 363
K + A +S HD + ++ E E K L R + + ++A+W +
Sbjct: 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE---TD 1379
Query: 364 TLQKAETLPEIEAQLAQRVAALNKAEE----RHGNFEERLRQLEAQLEEKNQELQRARQR 419
+Q+ E L E + +LAQR+ + E + + E+ ++L+ ++E+ +++RA
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLN 479
D + DK+L+E + + E +L+E SLS E+ +K +E L
Sbjct: 1440 AAALDKKQRNF----DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Query: 480 KEQLLAEMERMQMEIDQL 497
E + E + ++ EI L
Sbjct: 1496 LETVKRENKNLEQEIADL 1513
Score = 73.2 bits (178), Expect = 1e-12
Identities = 114/541 (21%), Positives = 221/541 (40%), Gaps = 54/541 (9%)
Query: 22 DEAGGELERLMVTMLTERE----RLLETLREA--QDGLATAQLRLR------ELGHEKDS 69
+EAGG + + + +RE +L L EA Q A LR + ELG + D+
Sbjct: 1152 EEAGG-VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN 1210
Query: 70 LQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNT-RLLLEHLECLVSRHE 128
LQR + Q+ E L + L E +++ KA R L + L ++E
Sbjct: 1211 LQR-----VKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 1265
Query: 129 ---RSL-RMTVVKRQAQSPGG-VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVA- 182
RSL +T K + Q+ G +S ++E +++ S K + E L+ LE
Sbjct: 1266 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325
Query: 183 ---VLEEELELSNQETLNLREQLSRRRSG---LEEPGKDGDGQTLANGLGPGGDSNRRTA 236
L L+ S + LREQ + G L+ + + D+ +RT
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1385
Query: 237 ELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALA 296
ELEEA ++ L +++ EE++ + + E+ +LQ ++++ +
Sbjct: 1386 ELEEAKKK--------------LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431
Query: 297 QREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDD 356
E L+K+ + + L + K E A E+ S ++SR L+ L
Sbjct: 1432 DVERANSLAAALDKKQRNFDK---VLAEWKTKCEESQAELEA----SLKESRSLSTELFK 1484
Query: 357 AKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRA 416
K ++ L + ET+ L Q +A L + +G L + Q+E + ++Q A
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 417 RQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEE-KNSLSEEIANMKKLQDE 475
+ + +H + + L++ + + E+ +E+ K + + M+ D
Sbjct: 1545 LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA 1604
Query: 476 LLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVA 535
+ ++ + + ++M+ +++++ + S +R + LR Q + HLD +
Sbjct: 1605 EVRSRNEAIRLKKKMEGDLNEIEIQ-LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663
Query: 536 G 536
G
Sbjct: 1664 G 1664
Score = 68.6 bits (166), Expect = 3e-11
Identities = 101/463 (21%), Positives = 191/463 (41%), Gaps = 48/463 (10%)
Query: 78 LPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVV 136
+ +EF EL + E EE++ L E+N+ +L ++ E L+ ER ++
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 137 KRQAQS-----PGGVSSEVEV---LKALKSLFEHHKALDEKVRERLRMALERVAVLEEEL 188
K Q ++ E E+ L A K E + +K + L + L +V E+E
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV---EKEK 969
Query: 189 ELSNQETLNLREQLS----------RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAEL 238
+ + NL E+LS R + L+E + A N+ ++L
Sbjct: 970 HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE-DKVNSLNKTKSKL 1028
Query: 239 EEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQR 298
E+ +E + + Q ++ L R +LE +L A + E +L LK+ +
Sbjct: 1029 EQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEY 1088
Query: 299 EDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAK 358
++ ++ + L Q++ L ++LE E+ ++ + ++E++ A L++
Sbjct: 1089 CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELS 1148
Query: 359 QKLQQ----TLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE----AQLEEKN 410
++L++ T + E + EA+ + L +A +H LR+ A+L E+
Sbjct: 1149 ERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI 1208
Query: 411 QELQRARQR-EKMNDDHNKRLSETVDKLLSESNERLQL---------HLKERMGALEE-K 459
LQR +Q+ EK + + + + S S + L L E G EE +
Sbjct: 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268
Query: 460 NSLSEEIANMKKLQDEL------LLNKEQLLAEMERMQMEIDQ 496
SLSE +LQ E L KE +++++ R + Q
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311
Score = 66.2 bits (160), Expect = 2e-10
Identities = 104/436 (23%), Positives = 185/436 (42%), Gaps = 68/436 (15%)
Query: 83 AALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQS 142
A KE+ +E+ + ++E+A+ +A+R L E L LV + + L++ V QA+S
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKE---LEEKLVTLV-QEKNDLQLQV---QAES 896
Query: 143 PGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQL 202
+ +E + +K+ F+ L+ K++E A + EEE+ N E + +L
Sbjct: 897 ENLLDAEERCDQLIKAKFQ----LEAKIKEVTERAED-----EEEI---NAELTAKKRKL 944
Query: 203 SRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQ 262
S L++ D + TLA + E ++ E+ L E +A L R+
Sbjct: 945 EDECSELKKDIDDLE-LTLAK-------VEKEKHATENKVKNLTEELSGLDETIAKLTRE 996
Query: 263 MSQLEE-------ELGTAHRELGKAEEANSKLQR---DLKEALAQ----REDMEERITTL 308
L+E +L ++ + SKL++ DL+ +L Q R D+E L
Sbjct: 997 KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL 1056
Query: 309 EKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKA 368
E AQ L + +L+ L K+ Y Q + K ++K+++ +
Sbjct: 1057 EGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Query: 369 ETL-PEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQ------ELQRARQREK 421
E L EIEA+ A R K E++ ++ L +L +LEE EL + R+ E
Sbjct: 1117 EELEEEIEAERATRA----KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEF 1172
Query: 422 MNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKE 481
+ L E L + + AL +K+ ++ +A + + D L K+
Sbjct: 1173 LK--------------LRRDLEEATLQHEAMVAALRKKH--ADSVAELGEQIDNLQRVKQ 1216
Query: 482 QLLAEMERMQMEIDQL 497
+L E ++EID L
Sbjct: 1217 KLEKEKSEFKLEIDDL 1232
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/511 (21%), Positives = 216/511 (42%), Gaps = 86/511 (16%)
Query: 34 TMLTERERLLETLREAQDGLATAQLRLRELGHEK-DSLQ--RQLSIALPQEFAALTKELN 90
T E + LE + L+T +L+ E D L+ ++ + L QE A LT+++
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518
Query: 91 LCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHE-RSLRMTVVKRQAQSPGGVSSE 149
+ + E E+ +++ E+ + +L LE E + E + LR+ + Q V SE
Sbjct: 1519 ENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ------VKSE 1572
Query: 150 VEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGL 209
++ + + E + +++ R R + L+ E+ S E + L++++ + +
Sbjct: 1573 ID-----RKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR-SRNEAIRLKKKMEGDLNEI 1626
Query: 210 EEPGKDGDGQ---TLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQL 266
E + Q TL + G L++AL Q L+E+LA++ R+ + L
Sbjct: 1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQE----DLKEQLAIVERRANLL 1682
Query: 267 EEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDAN 326
+ E+ L + E A +++L D ER+ L + TSL
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELL-------DSNERVQLLHT-------QNTSLIHTK 1728
Query: 327 DKLENELASKESLY-------RQSEEKSRQ-------LAEWL---DDAKQKLQQTLQKAE 369
KLE +L +S R +EEK+++ +AE L D L++ + E
Sbjct: 1729 KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1788
Query: 370 -TLPEIEAQLAQ-RVAALNKAEERHGNFEERLRQLEAQLE---EKNQEL--------QRA 416
T+ +++ +L + AL +++ E R+R+LE +LE +KN E +R
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRV 1848
Query: 417 RQREKMNDDHNK---RLSETVDKL----------LSESNERLQLHL------KERMGALE 457
++ +++ K RL + VDKL E++E+ HL + + E
Sbjct: 1849 KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908
Query: 458 EKNSLSEEIANMKKLQDELLLNKEQLLAEME 488
E+ ++E N + + + ++ E E
Sbjct: 1909 ERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
Score = 56.2 bits (134), Expect = 2e-07
Identities = 54/229 (23%), Positives = 106/229 (46%), Gaps = 26/229 (11%)
Query: 275 RELGKAEEANSKLQRDLKEALAQREDMEERITTL--EKRYLSAQREATSLHDANDKLENE 332
+E+ +E K + +L ++ A+R+++EE++ TL EK L Q +A S EN
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAES--------ENL 899
Query: 333 LASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERH 392
L +EE+ QL + + K+++ ++AE EI A+L A K E+
Sbjct: 900 L--------DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAEL---TAKKRKLEDEC 948
Query: 393 GNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKER 452
++ + LE L + +E + K + L ET+ KL E + H +
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ-- 1006
Query: 453 MGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMER-MQMEIDQLRGR 500
AL++ + +++ ++ K + +L E L + +E+ ++ +D R +
Sbjct: 1007 --ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK 1053
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 89.4 bits (220), Expect = 2e-17
Identities = 100/439 (22%), Positives = 193/439 (43%), Gaps = 39/439 (8%)
Query: 62 ELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLE 121
ELG + + LQR+L A + A T+++ + +++LL +EE+ EL+AER + + H
Sbjct: 602 ELGEKIEVLQRELEQA--RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH-- 657
Query: 122 CLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERV 181
+R L + + ++ G E + L+ K+L + + +E + ++ E
Sbjct: 658 -----RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAT 712
Query: 182 AVLEEE--LELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELE 239
+ + +E + +ET ++ RR GLE+ K+ GL GG
Sbjct: 713 VLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKE------TRGLVDGG---------- 756
Query: 240 EALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRE 299
EA+E +LR++L L + QLEE L + E G A L+ L+EA
Sbjct: 757 EAVE------ARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLA 810
Query: 300 DMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQ 359
+ + TL + ++ L +LE + K L R + +++L + +D+KQ
Sbjct: 811 RLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ---KRLLDRTVDRLNKELEKIGEDSKQ 867
Query: 360 KLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQR 419
LQQ + E E + + VA + + + E+ ++L+++ Q L++A Q
Sbjct: 868 ALQQLQAQLEDYKE---KARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA 924
Query: 420 EKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLN 479
+ D + E + + L + + + + + L E+++ ++ DE
Sbjct: 925 SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNT 984
Query: 480 KEQLLAEMERMQMEIDQLR 498
E L + R + ++DQLR
Sbjct: 985 VELLTDRVNRGRDQVDQLR 1003
Score = 87.0 bits (214), Expect = 9e-17
Identities = 126/539 (23%), Positives = 222/539 (41%), Gaps = 89/539 (16%)
Query: 30 RLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS-------------I 76
R V+++ E+ ++ L G A EL + + LQR+L +
Sbjct: 334 RRKVSLVLEK---MQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQV 390
Query: 77 ALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVV 136
L ++ T+E + +E L R+ E + E N + LL+ E L RH ++ +
Sbjct: 391 GLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDL--RHGLETQVMEL 448
Query: 137 KRQAQSPGGVSSEVEVLKALKSLFEHHKALDE------KVRERLRMALERVAVLE----E 186
+ + + G EVL LK L E + L+E +V E+LR+ + L+ E
Sbjct: 449 QNKLKHVQGPEPAKEVL--LKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKE 506
Query: 187 ELELSNQETLNLREQLSRRRSGLEEPGKDGDG------------QTLANGLGPG-GDSNR 233
E+ +QE ++R+Q R L +D L GL +++
Sbjct: 507 EVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSE 566
Query: 234 RTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKE 293
T + ++ + ++ ++ L L + ++EEELG E LQR+L++
Sbjct: 567 ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG----------EKIEVLQRELEQ 616
Query: 294 ALAQREDMEERITTLEKRYLSAQREATSLHDANDKLE-------NELASKESLYRQSEEK 346
A A D + + L+K L Q E L E EL + ++ R ++
Sbjct: 617 ARASAGDTRQ-VEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
Query: 347 SRQLAEWLDDAKQKLQQTLQ------KAETLPEIEAQ-LAQRVAA----LNKAEERHGNF 395
R+L E ++ LQQ Q KA+ + E EA L QR AA L + +E + F
Sbjct: 676 GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEF 735
Query: 396 EERLRQLEAQLEE-----KNQELQRARQREKMN--DDHNKRLSETV------DKLLSESN 442
R+ LE QL+E E AR R+K+ + ++L E + + L+ +
Sbjct: 736 RRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK 795
Query: 443 ERLQLHLKERMGAL----EEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQL 497
L+ L+E L +E+ +L+ + K ++ L K +L + + +D+L
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL 854
Score = 63.5 bits (153), Expect = 1e-09
Identities = 88/405 (21%), Positives = 161/405 (39%), Gaps = 36/405 (8%)
Query: 27 ELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALT 86
+LE + E L R + L AQ L LG E+ +L R L Q
Sbjct: 776 QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
Query: 87 KELNL-CREQLLEREEEIAELKAER--NNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP 143
+ L +++LL+R + + E+ +++ L+ L+ + ++ R V Q Q+
Sbjct: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAK 895
Query: 144 GGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLS 203
S + L L + +RLR AL+ + L +E L+
Sbjct: 896 DWASEAEKTSGGLSRL--------QDEIQRLRQALQASQAERDTARLD-------KELLA 940
Query: 204 RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQM 263
+R GLE Q N D R+ LEE + R E+ + + + +L ++
Sbjct: 941 QRLQGLE--------QEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRV 992
Query: 264 SQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLH 323
++ +++ EL + A L+ D Q +D++ R+ + E + + L
Sbjct: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE-GFQKPSASLSQLE 1051
Query: 324 DANDKLENELASKE-------SLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEA 376
N L+ L ++E S R+ E K ++L+ ++D +Q + QK + ++A
Sbjct: 1052 SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVND--QKDQLSLRVKA 1109
Query: 377 QLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREK 421
Q A + E G ++ R++E Q E Q R + EK
Sbjct: 1110 LKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEK 1154
Score = 63.2 bits (152), Expect = 1e-09
Identities = 102/459 (22%), Positives = 182/459 (39%), Gaps = 62/459 (13%)
Query: 34 TMLTERERLLET-LREAQDGLATAQLRLRELGHEKDSLQRQ--------LSIALPQEFAA 84
T+L +R +ET LRE Q+ + R R LG E+ + + + L +
Sbjct: 712 TVLGQRRAAVETTLRETQE--ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR 769
Query: 85 LTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPG 144
L E E L +EE L A + LE + ++R + + + R + G
Sbjct: 770 LEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQ--TLNRALEEEG 827
Query: 145 GVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAV-LEEELELSNQETLNLREQLS 203
+ EVL+ K+ E K L ++ +RL LE++ ++ L+ + + +E+
Sbjct: 828 ---KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKAR 884
Query: 204 RRRSGLEEPGKD--GDGQTLANGLG-------------PGGDSNRRTAELEEALERQRA- 247
R + + KD + + + GL + R TA L++ L QR
Sbjct: 885 REVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQ 944
Query: 248 ----EVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEE 303
E + RQ+ LEE++ EL + + L + Q + +
Sbjct: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRT 1004
Query: 304 RITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQ 363
+ + + SL N L+ LAS E + S S+ L+ Q LQ+
Sbjct: 1005 ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQ-----LESQNQLLQE 1059
Query: 364 TLQKAE----TLPEIEAQLAQRVAALN---KAEERHGNFEE-----RLRQLEAQLEEKNQ 411
LQ E L +L ++V L+ + E +H N ++ R++ L+ Q++E +
Sbjct: 1060 RLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEE 1119
Query: 412 ELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK 450
E++R D K+ V++ E NE+LQ +K
Sbjct: 1120 EIERL-------DGLRKKAQREVEE-QHEVNEQLQARIK 1150
Score = 48.1 bits (113), Expect = 5e-05
Identities = 78/310 (25%), Positives = 133/310 (42%), Gaps = 32/310 (10%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQR-----QLSIALPQEFAALTKELNLCR 93
R + + R+A+D + A+ L +D +QR Q S A ++ A L KEL R
Sbjct: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA-ERDTARLDKELLAQR 942
Query: 94 EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSL---RMTV------VKRQAQSPG 144
Q LE+E E K +++ L+ LE VSR E L + TV V R
Sbjct: 943 LQGLEQEAE--NKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVD 1000
Query: 145 GVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEE-ELELSNQETLNLREQLS 203
+ +E+ ++ + E K E+ + L+ L ++ LS E+ N QL
Sbjct: 1001 QLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQN---QLL 1057
Query: 204 RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQM 263
+ R EE K T R+ EL +E +R V +++L++ ++
Sbjct: 1058 QERLQAEEREKTVLQST-------NRKLERKVKELSIQIEDERQHVNDQKDQLSL---RV 1107
Query: 264 SQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEK-RYLSAQREATSL 322
L+ ++ A E+ + + K QR+++E E ++ RI +LEK + A R A
Sbjct: 1108 KALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAES 1167
Query: 323 HDANDKLENE 332
N+ L ++
Sbjct: 1168 ALKNEGLSSD 1177
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 89.4 bits (220), Expect = 2e-17
Identities = 136/524 (25%), Positives = 237/524 (45%), Gaps = 60/524 (11%)
Query: 13 GRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQ- 71
G RG+ + ELE V++ E+ L L+ QD LA A+ R L K L+
Sbjct: 907 GLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEG 966
Query: 72 --RQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHER 129
++LS L E + +L R +L E+E ELK + ++ +L L E E+
Sbjct: 967 KVKELSERLEDE-EEVNADLAARRRKL---EDECTELKKDIDDLKLTLAKAE-----KEK 1017
Query: 130 SLRMTVVKRQAQSPGGVSSEV-EVLKALKSLFE-HHKALDEKVRERLRMALERVAVLE-- 185
VK + + V + K K+L E H +AL + E R++ A L
Sbjct: 1018 QATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLE 1077
Query: 186 ---EELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEAL 242
E+LE S ++ LR R + LE GD + + D+ + +LEE L
Sbjct: 1078 QQVEDLECSLEQEKKLRMDTERAKRKLE-----GDLKLTQESV---ADAAQDKQQLEEKL 1129
Query: 243 ERQRAEVCQLRERL-------AVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEAL 295
+++ +E+ QL R+ A + +++ +L+ EL A +++++ EA
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 296 AQREDMEERITTLEKRYLSA-QREATSLHDAN-DKLENEL--------ASKESLYRQSEE 345
+ E++ ER+ E SA QRE +A +L EL A+ +L R+ E
Sbjct: 1190 RELEELSERLE--EAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247
Query: 346 KSRQLAEWLDDAKQKLQQTLQKAETLPEIEA-QLAQRVAALNK----AEERHGNFEERLR 400
+ +L E + D+ Q+++Q L+K ++ +E LA V L + AE+ +E++L
Sbjct: 1248 GAAELGEQV-DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 401 QLEAQLEEKNQELQRA---RQREKMNDDHNKRLSETVDKLLSESNERLQL---HLKERMG 454
+ + ++EE ++L A R R + RL E + L+S+ + L L+E
Sbjct: 1307 EAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRR 1366
Query: 455 ALEEKNSLSEEIAN-MKKLQDELLLNKEQLLAEMERMQMEIDQL 497
LEE++ +A+ ++ L+ + L +EQ E E Q E+ +L
Sbjct: 1367 QLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE-AQAELQRL 1409
Score = 74.7 bits (182), Expect = 5e-13
Identities = 111/500 (22%), Positives = 211/500 (42%), Gaps = 49/500 (9%)
Query: 8 TISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQD---GLATAQLRLRELG 64
T+ + +A D+ LER + + E + L AQ GL T RLR G
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRH-G 1536
Query: 65 HEK-----DSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEH 119
HE+ ++L+R+ + L +E + LT +++L + + E E+ L+ E++ + LE
Sbjct: 1537 HEEALEALETLKRE-NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 120 LECLVSRHE-RSLRMTVVKRQAQSPGGVSSEVEVLKALK-----SLFEHHK--------A 165
E + E ++LR+ + Q V +EV+ A K +L +H+ +
Sbjct: 1596 AEGALELEETKTLRIQLELSQ------VKAEVDRKLAEKDEECANLRRNHQRAVESLQAS 1649
Query: 166 LDEKVRER---LRMALERVAVLEE-ELELSNQETLNLREQLSRRRSGL----EEPGKDGD 217
LD + R R LR+ + L + EL+L + Q + R E+ G+D +
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 218 GQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHREL 277
+ A RR + L LE RA + Q + +++ + E L H +
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769
Query: 278 GKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKE 337
KL+ DL + + E+ + E++ A +A + + K ++ A E
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1829
Query: 338 SLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHG---- 393
+ + E+ R+L L++A+Q + +K + ++EA++ + A L+ +++H
Sbjct: 1830 RMKKTLEQTVRELQARLEEAEQAALRGGKKQ--VQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 394 ---NFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLK 450
E R+++L Q EE + L R + K ++ ++N L + K
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRK 1947
Query: 451 --ERMGALEEKNSLSEEIAN 468
+ EE+ ++E AN
Sbjct: 1948 AQHELDDAEERADMAETQAN 1967
Score = 74.3 bits (181), Expect = 6e-13
Identities = 118/510 (23%), Positives = 216/510 (42%), Gaps = 71/510 (13%)
Query: 39 RERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLS-IALPQE-----FAALTKELNLC 92
+++L L+EA++G+ A + L K LQ + + L E AAL K+
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 93 REQLLER----EEEIAELKAERNNTRLLLEHLECLVSRHERSLR-MTVVKRQAQSPGGVS 147
L ER EE EL+A + +R L L L HE +L + +KR+ ++ +
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN---LQ 1555
Query: 148 SEVEVL--------KALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLR 199
E+ L K+++ L + KAL+ + E ++ ALE E LEL +TL ++
Sbjct: 1556 EEISDLTDQVSLSGKSIQELEKTKKALEGEKSE-IQAALEEA---EGALELEETKTLRIQ 1611
Query: 200 EQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALE---RQRAEVCQLRERL 256
+LS+ ++ ++ + D + AN + R L+ +L+ R R E +L++++
Sbjct: 1612 LELSQVKAEVDRKLAEKD-EECAN---LRRNHQRAVESLQASLDAETRARNEALRLKKKM 1667
Query: 257 AVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQRED---------------- 300
++ LE +LG A R+ +A+ A +Q LKE A R++
Sbjct: 1668 E---GDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALE 1724
Query: 301 ---------MEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLA 351
+EE LE+ S + L +A ++L + L Q ++ LA
Sbjct: 1725 RRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 352 EWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGN-------FEERLRQLEA 404
+ + ++ Q+ + E + A L K ++ + E+ +R+L+A
Sbjct: 1785 QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQA 1844
Query: 405 QLEEKNQELQRARQREKMNDDHNKR-LSETVDKLLSESNERLQLHLKERMGALEEKNSLS 463
+LEE Q R +++ + R L +D + E L+ K E
Sbjct: 1845 RLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAE 1904
Query: 464 EEIANMKKLQDELLLNKEQLLAEMERMQME 493
E+ N+ ++QD L++K Q + + Q E
Sbjct: 1905 EDRKNLARMQD--LVDKLQSKVKSYKRQFE 1932
Score = 65.5 bits (158), Expect = 3e-10
Identities = 153/679 (22%), Positives = 262/679 (38%), Gaps = 122/679 (17%)
Query: 14 RRGSALGPDEAGGELERLM-VTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQR 72
RR A G E G +++ L V E+E+ LR D LA + L K S ++
Sbjct: 1242 RRKQAEGAAELGEQVDSLQRVRQKLEKEK--SELRMEVDDLAA---NVETLTRAKASAEK 1296
Query: 73 QLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLR 132
Q A K L R QL + + L+ E LLE ECL+S+ R
Sbjct: 1297 LCRTYEDQLSEAKIKVEELQR-QLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKA 1355
Query: 133 MTVVKRQAQSPGGVSSEVEVLKALKSLFEHH-KALD---EKVRERLRMALERVAVLEEEL 188
+ AQS + ++E KS H +AL + +RE+ E A L+ L
Sbjct: 1356 LA-----AQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLL 1410
Query: 189 ELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAE 248
+N E R + D+ +RT ELEEA ++
Sbjct: 1411 SKANAEVAQWRSKYE-------------------------ADAIQRTEELEEAKKK---- 1441
Query: 249 VCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKL--------------------- 287
L ++ + EE + A+ + E+A +L
Sbjct: 1442 ----------LALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAAL 1491
Query: 288 ---QRDLKEALAQREDMEERITTLEKRYLSAQREA----TSLHDANDKLENELASKESLY 340
QR L+ AL +R EE +++ +AQRE+ T L E L + E+L
Sbjct: 1492 DKKQRHLERALEERRRQEEE---MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548
Query: 341 RQSEEKSRQLAEWLDDAK------QKLQQTLQKAE-TLPEIEAQLAQRVAALNKAEERHG 393
R+++ ++++ D Q+L++T + E EI+A L + AL E +
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Query: 394 NFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQ-LHLKER 452
+ L Q++A+++ K E + + + +H + + L +E+ R + L LK++
Sbjct: 1609 RIQLELSQVKAEVDRKLAE--KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKK 1666
Query: 453 MGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGS 512
M + N L ++ + + E + A+++ Q D+ + + ++
Sbjct: 1667 MEG--DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQA---Q 1721
Query: 513 ALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWER-----SAPAGSIP 567
ALE R S A L+ A G+R R ++E + ER S G +
Sbjct: 1722 ALERRASLL-----AAELEELRAAL-EQGERSR-RLAEQELLEATERLNLLHSQNTGLLN 1774
Query: 568 PPFP-----GELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQE 622
+L G EE A+ AE + D A M+ E+L+ ++
Sbjct: 1775 QKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD----AAMMAEELKKEQDTSAHLER 1830
Query: 623 EKETTEQRAEELESRVSSS 641
K+T EQ EL++R+ +
Sbjct: 1831 MKKTLEQTVRELQARLEEA 1849
Score = 60.1 bits (144), Expect = 1e-08
Identities = 95/468 (20%), Positives = 183/468 (39%), Gaps = 75/468 (16%)
Query: 35 MLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQL---------SIALPQEFAAL 85
M E +RLL +D L T Q +R K+ +L S +E AAL
Sbjct: 846 MRLEYQRLLG----GRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAAL 901
Query: 86 TKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGG 145
EL R L E + EL+ H+ +++ +L++ QA+
Sbjct: 902 RAELRGLRGALAAAEAKRQELEET---------HVSITQEKNDLALQL-----QAEQDNL 947
Query: 146 VSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRR 205
+E +KS + L+ KV+E L E LE ++E +N L+ R
Sbjct: 948 ADAEERCHLLIKSKVQ----LEGKVKE-----------LSERLE--DEEEVNA--DLAAR 988
Query: 206 RSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQ 265
R LE+ EL++ ++ + + + + ++
Sbjct: 989 RRKLED----------------------ECTELKKDIDDLKLTLAKAEKEKQATENKVKN 1026
Query: 266 LEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDA 325
L EE+ + + + LQ ++AL + E+R++ L K L +++ L +
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECS 1086
Query: 326 NDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAAL 385
++ + E R+ E + E + DA Q QQ +K L + +++L+Q +
Sbjct: 1087 LEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEK---LKKKDSELSQLSLRV 1143
Query: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
+ ++++++L+A+ EE +EL+ R + + +++L +ERL
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEEL----SERL 1199
Query: 446 QLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQME 493
+ G E E+ +++ +E L E +A + R Q E
Sbjct: 1200 EEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247
Score = 57.8 bits (138), Expect = 6e-08
Identities = 102/424 (24%), Positives = 164/424 (38%), Gaps = 51/424 (12%)
Query: 22 DEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQE 81
+EA G LE E + L E A +L E E +L+R A+
Sbjct: 1594 EEAEGALE-------LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESL 1646
Query: 82 FAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQ 141
A+L E E L +++ ++ + N+ L L H + + + R+ QAQ
Sbjct: 1647 QASLDAETRARNEALRLKKK----MEGDLNDLELQLGHATRQATEAQAATRLM----QAQ 1698
Query: 142 SPGGVSSEVEVLKALKSLFEHHKALDEKVR------ERLRMALERVAVLEEELELSNQET 195
+ E + L E +AL+ + E LR ALE+ E L+ QE
Sbjct: 1699 LKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQG---ERSRRLAEQEL 1755
Query: 196 LNLREQLS---RRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQL 252
L E+L+ + +GL K + LA G ++ + E EE ++ + +
Sbjct: 1756 LEATERLNLLHSQNTGLLNQKKKLEAD-LAQLSGEVEEAAQERREAEEKAKKAITDAAMM 1814
Query: 253 RERL-------AVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERI 305
E L A L R LE+ + L +AE+A L+ Q + +E ++
Sbjct: 1815 AEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA------LRGGKKQVQKLEAKV 1868
Query: 306 TTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTL 365
LE + Q++ K E + KE Y Q+EE + LA + D KLQ +
Sbjct: 1869 RELEAELDAEQKKHAEALKGVRKHERRV--KELAY-QAEEDRKNLAR-MQDLVDKLQSKV 1924
Query: 366 QK-AETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMND 424
+ E E Q +A KA+ + EER A + E RAR R+ +
Sbjct: 1925 KSYKRQFEEAEQQANTNLAKYRKAQHELDDAEER-----ADMAETQANKLRARTRDALGP 1979
Query: 425 DHNK 428
H +
Sbjct: 1980 KHKE 1983
Score = 50.4 bits (119), Expect = 1e-05
Identities = 83/394 (21%), Positives = 155/394 (39%), Gaps = 76/394 (19%)
Query: 264 SQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRY----LSAQREA 319
+Q EEEL EL L+ L A A+R+++EE ++ + L Q E
Sbjct: 892 AQAEEELAALRAEL-------RGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQ 944
Query: 320 TSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLA 379
+L DA ++ + SK L E K ++L+E L+D + E+ A LA
Sbjct: 945 DNLADAEERCHLLIKSKVQL----EGKVKELSERLEDEE--------------EVNADLA 986
Query: 380 QRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLS 439
R K E+ ++ + L+ L + +E Q + K + L E+V +L
Sbjct: 987 AR---RRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTK 1043
Query: 440 ESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRG 499
E + H ++ +G L+ + + K ++ + + E L + ++++M+ ++ +
Sbjct: 1044 EKKALQEAH-QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAK- 1101
Query: 500 RPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWER 559
R L G + S A L+ ++ KD E
Sbjct: 1102 -------RKLEGDLKLTQESVADAAQDKQQLE------------------EKLKKKDSEL 1136
Query: 560 SAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKL 619
S + + E E + GA++ ++Q A L+E+LEA
Sbjct: 1137 SQLSLRV--------------EDEQLLGAQMQKKI--KELQARAEELEEELEAERAARAR 1180
Query: 620 IQEEKETTEQRAEELESRVSSSGLDSLGRYRSSC 653
+++++ + EEL R+ +G S G+ R C
Sbjct: 1181 VEKQRAEAARELEELSERLEEAGGASAGQ-REGC 1213
Score = 34.3 bits (77), Expect = 0.73
Identities = 30/138 (21%), Positives = 59/138 (42%), Gaps = 18/138 (13%)
Query: 361 LQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQRE 420
L ++ Q E L + A+L AL AE + EE + ++ +L Q E
Sbjct: 888 LLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEET----HVSITQEKNDLALQLQAE 943
Query: 421 KMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNK 480
+ N L+++ ER L +K ++ + LSE + + +++ +L +
Sbjct: 944 QDN--------------LADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARR 989
Query: 481 EQLLAEMERMQMEIDQLR 498
+L E ++ +ID L+
Sbjct: 990 RKLEDECTELKKDIDDLK 1007
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,304,466
Number of Sequences: 37866
Number of extensions: 2684262
Number of successful extensions: 28986
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 424
Number of HSP's successfully gapped in prelim test: 1726
Number of HSP's that attempted gapping in prelim test: 13734
Number of HSP's gapped (non-prelim): 9266
length of query: 1194
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1080
effective length of database: 13,930,794
effective search space: 15045257520
effective search space used: 15045257520
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.