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Search of human proteins with 31652236
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
(678 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens] 1296 0.0
gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens] 1287 0.0
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] 746 0.0
gi|116517292 cut-like 2 [Homo sapiens] 348 7e-96
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 3e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 91 3e-18
gi|21735548 centrosomal protein 2 [Homo sapiens] 89 2e-17
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 88 2e-17
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 87 7e-17
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 87 7e-17
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 87 7e-17
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 87 7e-17
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 87 7e-17
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 87 7e-17
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 87 7e-17
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 87 7e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 86 1e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 86 1e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 86 1e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 86 1e-16
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 86 1e-16
gi|38044112 restin isoform b [Homo sapiens] 85 3e-16
gi|4506751 restin isoform a [Homo sapiens] 85 3e-16
gi|31982906 cingulin-like 1 [Homo sapiens] 83 1e-15
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 82 2e-15
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 82 2e-15
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 82 2e-15
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 82 2e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 80 5e-15
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 80 6e-15
>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
Length = 678
Score = 1296 bits (3354), Expect = 0.0
Identities = 678/678 (100%), Positives = 678/678 (100%)
Query: 1 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL
Sbjct: 1 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
Query: 61 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH
Sbjct: 61 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ
Sbjct: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI
Sbjct: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE
Sbjct: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 360
VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA
Sbjct: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 360
Query: 361 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420
DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR
Sbjct: 361 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420
Query: 421 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 480
CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA
Sbjct: 421 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 480
Query: 481 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 540
LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL
Sbjct: 481 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 540
Query: 541 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 600
RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW
Sbjct: 541 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 600
Query: 601 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 660
DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH
Sbjct: 601 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 660
Query: 661 LHKFHENDNGAAAGDLWQ 678
LHKFHENDNGAAAGDLWQ
Sbjct: 661 LHKFHENDNGAAAGDLWQ 678
>gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]
Length = 676
Score = 1287 bits (3331), Expect = 0.0
Identities = 676/678 (99%), Positives = 676/678 (99%), Gaps = 2/678 (0%)
Query: 1 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL
Sbjct: 1 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
Query: 61 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH
Sbjct: 61 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ
Sbjct: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI
Sbjct: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV AIEVLTRSSLE
Sbjct: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLE 298
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 360
VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA
Sbjct: 299 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA 358
Query: 361 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420
DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR
Sbjct: 359 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 418
Query: 421 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 480
CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA
Sbjct: 419 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATA 478
Query: 481 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 540
LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL
Sbjct: 479 LFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSL 538
Query: 541 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 600
RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW
Sbjct: 539 RADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPW 598
Query: 601 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 660
DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH
Sbjct: 599 DKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADH 658
Query: 661 LHKFHENDNGAAAGDLWQ 678
LHKFHENDNGAAAGDLWQ
Sbjct: 659 LHKFHENDNGAAAGDLWQ 676
>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
Length = 1505
Score = 746 bits (1927), Expect = 0.0
Identities = 399/401 (99%), Positives = 401/401 (100%)
Query: 19 QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78
+L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL
Sbjct: 8 RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
Query: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK
Sbjct: 68 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
Query: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198
EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT
Sbjct: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
Query: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258
SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ
Sbjct: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
Query: 259 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 318
REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ
Sbjct: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307
Query: 319 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 378
RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA
Sbjct: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367
Query: 379 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 419
PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG
Sbjct: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408
Score = 35.0 bits (79), Expect = 0.23
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 18/168 (10%)
Query: 261 AETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE----IAQLVED 316
A ++EQL N ++ E+L R +L + +E + Q + D
Sbjct: 557 ARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSD 616
Query: 317 VQRLQASLT---KLRENSASQISQLEQQL-SAKNSTLKQLEEKLKG---------QADYE 363
Q + A + + REN +++L Q++ +N + + +++ ++ E
Sbjct: 617 EQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILE 676
Query: 364 EVKKELNILKSMEFA-PSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
+ K+EL + K+ E A PS +G+ ++ + +L + R ++++ AAL
Sbjct: 677 QAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAAL 724
>gi|116517292 cut-like 2 [Homo sapiens]
Length = 1486
Score = 348 bits (894), Expect = 7e-96
Identities = 197/401 (49%), Positives = 277/401 (69%), Gaps = 4/401 (0%)
Query: 1 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL 60
MAANVGSMFQYWKRFDL++LQ+EL++ A+ L+ RQ+ESE S K LIE REFKKN PE++
Sbjct: 1 MAANVGSMFQYWKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEI 60
Query: 61 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ-RL 119
R+ VAP+LKSFQ E+ ALSKRS+EAEAAFL+VYK+LI+ PDPVP + + L ++Q
Sbjct: 61 REMVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPS 120
Query: 120 HDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKL 179
D + ++ T + N E K Q + E + + AL E L
Sbjct: 121 FDPSGQPRRDLHTSWKRNPELLSPKEQREGTSPAGPTLTEGSRLPGIPGK--ALLTETLL 178
Query: 180 QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADE 239
Q + AEK++ LQE Q++ ++L EAE K++ L +AL+ T+ EL +L+ KYDEE +KADE
Sbjct: 179 QRNEAEKQKGLQEVQITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADE 238
Query: 240 IEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQA-IEVLTRSS 298
+ +IMT+LE+ANQRAE AQRE E+LREQL+S N S++LA + P ++ + +
Sbjct: 239 VGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPR 298
Query: 299 LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG 358
LE LA+K+REI +L++DVQ LQ+SL +L E SA+QI+ LE+QL+AK+ +++LEEKL+
Sbjct: 299 LEAALASKDREILRLLKDVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQA 358
Query: 359 QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
Q+DYEE+K EL+ILK+M+ A S + Q AKP + LL+ K
Sbjct: 359 QSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLLIAK 399
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.4 bits (233), Expect = 3e-19
Identities = 136/579 (23%), Positives = 249/579 (43%), Gaps = 81/579 (13%)
Query: 13 KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFK---------KNTPEDLRK- 62
K F+L QLQ ++D Q + ++ + R+ E E + + DL +
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 63 --QVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLID--VPDPVPALDLGQQLQLKVQR 118
+++ L+ G A + +K+ EA F + + L + + A L ++ V
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206
Query: 119 LHDIETENQKLRETLEEYNKEF-AEVKNQEVTIKAL---KEKIREYEQTLKNQAETIALE 174
L + Q++++ LE+ E E+ + I+AL K I +T+++Q I +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266
Query: 175 KEQKLQ--NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEE 232
EQ+ Q +D ++ +LQ + ++EE E + L + + +L +LK + +EE
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 233 TTAK---ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQL------ASQIQK 283
T AK A ++ D + ++ E Q L+ LS AN + IQ+
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 284 APDVEQAIEVLTRSSLEVE--LAAKEREIAQLVEDVQRLQASLTKLR---ENSASQISQL 338
++E+A + L + E E + A L + QRLQ + L E S + + L
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 339 EQQLSAKNSTLKQLEEKL-KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLL 397
+++ + L + ++KL + QA+ E +KE L + F ++ LE L
Sbjct: 1447 DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN--AYEEVVDQLETLRR 1504
Query: 398 EKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQR 457
E N++LQ E SDL+ + AE + EA T ++L+ + + DL +
Sbjct: 1505 E-NKNLQEE-------ISDLTEQIAETGKNLQEAEKT----KKLVEQEKSDLQVALE--- 1549
Query: 458 PDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRER-FRARN 516
+ EG+ EH KI +V LS + S+ +R ++
Sbjct: 1550 -EVEGSLEHEESKIL------------------------RVQLELSQVKSELDRKVIEKD 1584
Query: 517 QELEAENRLAQHTLQALQSELDS---LRADNIKLFEKIK 552
+E+E R +Q +ALQS LD+ R D ++L +K++
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
Score = 69.7 bits (169), Expect = 8e-12
Identities = 103/525 (19%), Positives = 210/525 (40%), Gaps = 102/525 (19%)
Query: 24 LDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSK 83
L+A L R +E E+ L+ + R +L + + L + L+K K
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKR--------NLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 84 EAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEV 143
E A V +L +++ + + + E + L+E ++ +
Sbjct: 971 EKHATENKVK-------------NLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 144 KNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEE 203
+++ + + K+ + L+ +LE+E+KL+ D +RKL+ + + +
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEG-----SLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 204 AEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLERANQRAEVA 257
E+ Q ++ L+K EL L+ K D+E K E++ + +LE +
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 258 QREAETLREQLSSANHSLQLASQIQKAPDVEQA-IEVLTRSSLEVELAAKEREIAQLVED 316
+ + E R L A +++ ++++A A IE+ + E + ++ E A L
Sbjct: 1133 RAKIEKQRSDL--ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL--- 1187
Query: 317 VQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSME 376
+ +A+ LR+ A +++L +Q+ L+++++KL + + E+K E++
Sbjct: 1188 --QHEATAATLRKKQADSVAELGEQI----DNLQRVKQKL--EKEKSELKMEID------ 1233
Query: 377 FAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATAT 436
D A +E AL S S++ C ++ + +E A
Sbjct: 1234 ----------DMASNIE---------------ALSKSKSNIERTCRTVEDQFSEIKAKDE 1268
Query: 437 EQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEG 496
+Q +LI L + +Q+ G HR+E+ I + T
Sbjct: 1269 QQTQLIHDLNMQKARLQT-----QNGELSHRVEEKESLISQLT----------------- 1306
Query: 497 QVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR 541
S ++ E R +E +A+N +A H LQ+ + + D LR
Sbjct: 1307 --KSKQALTQQLEELKRQMEEETKAKNAMA-HALQSSRHDCDLLR 1348
Score = 63.2 bits (152), Expect = 8e-10
Identities = 99/459 (21%), Positives = 187/459 (40%), Gaps = 87/459 (18%)
Query: 121 DIETENQKLRETLEEYNKEFA--EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 178
+ E E ++E E +E A E + +E+ K + + + L+ Q+ET L ++
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 179 LQNDFAEKERKLQETQMSTTSKLEEAEH-------KVQSLQTALEKTRTELFDLK---TK 228
+ + L+ T +LEE E K ++L+ + ++ DL+ TK
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967
Query: 229 YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQL----------- 277
++E A ++++ + ++ + +E ++L+E LQ+
Sbjct: 968 VEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027
Query: 278 -ASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQIS 336
A Q+ D+E ++E + ++E A ++ E D++ Q S+ L +
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE-----GDLKMSQESIMDLENDK----Q 1078
Query: 337 QLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLL 396
Q+E++L K L QL+ K+ D E+V S++F Q K L+ +
Sbjct: 1079 QIEEKLKKKEFELSQLQAKI----DDEQV-------HSLQF--------QKKIKELQARI 1119
Query: 397 LEKNRSLQSEN---AALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQ 453
E +++E+ A + SDL+ E+ R+ EA + Q E+ + E + Q
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE---FQ 1176
Query: 454 SIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
++R E +H EATA L + Q DS+ + Q + +
Sbjct: 1177 KMRRDLEEATLQH----------EATA----------ATLRKKQADSVAE-LGEQIDNLQ 1215
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIK 552
Q+LE E L+ E+D + A NI+ K K
Sbjct: 1216 RVKQKLEKEK-------SELKMEIDDM-ASNIEALSKSK 1246
Score = 47.8 bits (112), Expect = 3e-05
Identities = 83/368 (22%), Positives = 161/368 (43%), Gaps = 45/368 (12%)
Query: 74 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRET 132
EI+ L + S+ A A +V ++ AL L ++++ + + + N+++ ET
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDA--EIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAET 1643
Query: 133 LEEYNKEFAEVKNQEVTIK-ALKEKIREYEQ-TLKNQAETIALEK--EQKLQNDFAEKER 188
+ ++K+ ++ + AL+ EQ + + + LE+ E K+ + E+ R
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Query: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
+L E + L +A +VQ L + T L + K K + + E+E + +
Sbjct: 1704 RLSEQE------LLDASDRVQLLHSQ----NTSLINTKKKLEADIAQCQAEVENSIQESR 1753
Query: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE-LAAKE 307
A ++A+ A +A + E+L + +++K ++EQ ++ L E E LA K
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKG 1811
Query: 308 REIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKK 367
+ + +Q+L+ +++ +LE +L + K+ E LKG YE K
Sbjct: 1812 GK-----KQIQKLE-----------NRVRELENELDVEQ---KRGAEALKGAHKYERKVK 1852
Query: 368 ELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVR 427
E+ E QD L+ + K+ Q+E A + +N+ LS RC +Q
Sbjct: 1853 EMTY--QAEEDHKNILRLQDLVDKLQAKV--KSYKRQAEEAEEQ-ANTQLS-RCRRVQHE 1906
Query: 428 ITEAVATA 435
+ EA A
Sbjct: 1907 LEEAAERA 1914
Score = 45.4 bits (106), Expect = 2e-04
Identities = 52/256 (20%), Positives = 106/256 (41%), Gaps = 24/256 (9%)
Query: 16 DLQQLQRELDATATV--LANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
+L++++ L+ T L+ ++ R +L+ NT + L +A Q
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQC----QA 1743
Query: 74 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRET 132
E++ + S+ AE K + D L Q ++R+ ++E + L+
Sbjct: 1744 EVENSIQESRNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Query: 133 LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
L+E E +K + I+ L+ ++RE E L + EQK + + K +
Sbjct: 1801 LDE--AEQLALKGGKKQIQKLENRVRELENEL---------DVEQKRGAEALKGAHKYER 1849
Query: 193 TQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETTAKADEIEMIMTDLER 249
T + EE + LQ ++K + ++ K + +E + + + +LE
Sbjct: 1850 KVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEE 1909
Query: 250 ANQRAEVAQREAETLR 265
A +RA++A+ + LR
Sbjct: 1910 AAERADIAESQVNKLR 1925
Score = 42.7 bits (99), Expect = 0.001
Identities = 61/284 (21%), Positives = 119/284 (41%), Gaps = 26/284 (9%)
Query: 304 AAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 363
A E+E+A + ED +R + L + ++ L KN Q++ + + D E
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 364 EVKKELNILKS---MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420
E + ++KS +E E + + + L+ K R+L+ + ++L+ DL
Sbjct: 907 E--RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL--- 961
Query: 421 CAELQVRITEAVATATEQR-----ELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 475
EL + E ATE + E + LE+++S + ++ + A + L+ +
Sbjct: 962 --ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTK-EKKSLQEAHQQTLDDLQVEE 1018
Query: 476 KEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQS 535
+ L A E Q D L + Q ++ RA +LE R + L+ Q
Sbjct: 1019 DKVNGLI------KINAKLEQQTDDLEGSL-EQEKKLRA---DLERAKRKLEGDLKMSQE 1068
Query: 536 ELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERL 579
+ L D ++ EK+K + + D E +S Q+++++
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.9 bits (224), Expect = 3e-18
Identities = 131/616 (21%), Positives = 257/616 (41%), Gaps = 96/616 (15%)
Query: 13 KRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
++ +L R+L+ L +Q+E E++RK L +Q + D +K+V L + +
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA-DTKKKVDDDLGTIE 1388
Query: 73 GEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRET 132
+A K K+AEA L Q+L+ K +E +L++
Sbjct: 1389 SLEEAKKKLLKDAEA--------------------LSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 133 LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
L++ ++ +Q L++K ++++Q L + A E++ D AE E + +E
Sbjct: 1429 LDDLT---VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER---DRAEAEAREKE 1482
Query: 193 TQ-MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 251
T+ +S LEEA + + ++ R ++ DL + D++ + +LE++
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS--------KDDVGKNVHELEKSK 1534
Query: 252 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVE-QAIEVLTRSSLEVELAAKEREI 310
+ E ++ E +R QL LQ + +V QA++ L+ E +
Sbjct: 1535 RALE---QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 311 AQLVEDVQRLQASLTKLRENSASQIS--------------QLEQQLSAKNSTLKQLEEKL 356
L++ V+ L+A L R+ A ++ Q+E A++ +KQL +
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 357 KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSD 416
DY+ +E + FA S+ ++ K LE +L+ L S A R + +
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSK--ESEKKLKSLEAEILQLQEELASSERARRHAEQE 1709
Query: 417 LSGRCAELQVRITEAVATATEQREL---IARLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
E+ + A E+R L IA+LE++L + + E ++ +
Sbjct: 1710 RDELADEITNSASGKSALLDEKRRLEARIAQLEEELE--------EEQSNMELLNDRFRK 1761
Query: 474 PIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELE-AENRLAQHTLQA 532
+ L AA S A + D+ + Q + +A+ QELE A + T+ A
Sbjct: 1762 TTLQVDTLNAELAAERSAA---QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 533 LQSELDSL----------RADNIKLFEKIK------FLQSYPGRGSGSDDTELRYSSQYE 576
L++++ L RA KL + + F+Q + E R++ QY+
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV---------EDERRHADQYK 1869
Query: 577 ERLDPFSSFSKRERQR 592
E+++ ++ K+ +++
Sbjct: 1870 EQMEKANARMKQLKRQ 1885
Score = 85.9 bits (211), Expect = 1e-16
Identities = 143/599 (23%), Positives = 254/599 (42%), Gaps = 82/599 (13%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIEQSREF--KKNTPEDLRKQVAPLLKSFQGE 74
L+ +EL VL + ESE RK+L Q +E K + + LR ++A Q E
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE 1288
Query: 75 IDALSKRSKEAEAAFLNVYK-------RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ 127
+D +S +EAE + K +L D + + + Q+L L R+ +E E
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE-ETRQKLNLS-SRIRQLEEEKN 1346
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIAL--EKEQKLQNDFAE 185
L+E EE E KN E + AL+ ++ + ++ + + TI E ++KL D
Sbjct: 1347 SLQEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 186 KERKLQETQMSTTSKLEEAEHKVQ----SLQTALEKTRTELFDLKTKYDEETTAKADEIE 241
++L+E ++ KLE+ ++++Q L L+ R +L+ K + A+E +
Sbjct: 1404 LSQRLEEKALA-YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE-K 1461
Query: 242 MIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIE---VLTRSS 298
I RAE RE ET +L LA +++A + ++ E R+
Sbjct: 1462 SISARYAEERDRAEAEAREKET---------KALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 299 LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA-KNSTLK------- 350
+E +L + + ++ + V ++++ + +L + E +Q+ +LE +L A +++ L+
Sbjct: 1513 ME-DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 351 ---QLEEKLKGQADYEEVKKELNILKSMEF-APSEGAGTQDA-----AKPLEVLLLEKNR 401
Q E L+ + + E KK L I + E A E Q A K +E+ L +
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631
Query: 402 SLQSENAA----------LRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSI 451
+++ N A L+ D E + E A + E + + LE ++
Sbjct: 1632 QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ 1691
Query: 452 IQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAA--------PASGALPEGQVDSLLS 503
+Q + +E A H ++ E E T G +A A A E +++ S
Sbjct: 1692 LQE-ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Query: 504 IISSQRERFR-------ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +RFR N EL AE AQ + A Q L N +L K++ L+
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ----QLERQNKELKAKLQELE 1805
Score = 83.2 bits (204), Expect = 7e-16
Identities = 120/524 (22%), Positives = 227/524 (43%), Gaps = 86/524 (16%)
Query: 131 ETLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTLKN--------QAETIALEKEQKLQN 181
E L+ ++E +VK ++ ++ L+E R+++Q L+ QAET + ++++
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911
Query: 182 DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 241
A K+++L+E S++EE E + Q LQ +K + + DL+ + DEE A+
Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ---- 967
Query: 242 MIMTDLERANQRAEVAQREAE--TLREQLSS------------ANHSLQLASQIQKAPD- 286
LE+ A++ + E E L +Q S A S QLA + +KA +
Sbjct: 968 --KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 287 --VEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 344
+ EV+ S LE L +E+ +L + ++L T L++ QI++L+ Q+
Sbjct: 1026 AKIRNKQEVMI-SDLEERLKKEEKTRQELEKAKRKLDGETTDLQD----QIAELQAQIDE 1080
Query: 345 KNSTLKQLEEKLKG---QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR 401
L + EE+L+G + D E + K N LK + L+ + E
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKN-NALK--------------VVRELQAQIAELQE 1125
Query: 402 SLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQ----- 453
+SE A+ + DLS L+ + + + T Q+EL + EQ+++ ++
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 454 -----SIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQ--------VDS 500
Q D LE++ E +++A G + + +
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 501 LLSIISSQRERFRARNQELEAE----NRLAQHTLQ---ALQSELDSLRADNIKLFEK--I 551
+ + +R++ A+ QEL A+ +RL + LQ+ELD++ + ++ EK I
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV-STLLEEAEKKGI 1304
Query: 552 KFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL 595
KF + S DT+ + ++L+ S + E ++ L
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Score = 75.9 bits (185), Expect = 1e-13
Identities = 122/573 (21%), Positives = 215/573 (37%), Gaps = 52/573 (9%)
Query: 22 RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 81
REL A L + + SR + +Q R+ + E L+ ++ L + + + +KR
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL-EALKTELEDTLDTTAAQQELRTKR 1172
Query: 82 SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 141
E E A L D+ Q+ ++ L + + ++ + LE+ NK+
Sbjct: 1173 --EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK-NKQGL 1229
Query: 142 EVKNQEVT--IKALKEKIREYEQTLKN-----QAETIALEKEQKLQNDFAEKERKLQETQ 194
E N+E+ +K L++ E E K Q + + +L+ + AEK KLQ
Sbjct: 1230 ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 254
+ ++ LEEAE K ++L D + EET K + + + LE
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSL 1348
Query: 255 EVAQREAETLREQLSSANHSL--QLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 312
+ Q E E R+ L +L QLA +K D IE L + + +L ++Q
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA--KKKLLKDAEALSQ 1406
Query: 313 LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNIL 372
+E+ L K + ++ L L + LE+K K +K ++
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 373 KSMEFAPSEGAGTQDAAKPLEVL-----LLEKNRSLQSENAALRISNSDL---------- 417
+ E +E + K L + LE + +N LR DL
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 418 ------SGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKI 471
S R E QV E + T E+ E + +D + + + E L+
Sbjct: 1527 VHELEKSKRALEQQV---EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583
Query: 472 PEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQE--LEAENRLAQHT 529
E +E L L + + L++ S ++ ++ E +EA N+
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 530 LQAL----------QSELDSLRADNIKLFEKIK 552
++ L Q EL+ RA ++F + K
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Score = 75.1 bits (183), Expect = 2e-13
Identities = 120/563 (21%), Positives = 238/563 (42%), Gaps = 39/563 (6%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE-----DLRKQVAPLLKSF 71
L++ +++L A L+ R +E + +L + ++ + D ++QVA L+
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 72 QGEIDALSKRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKL 129
Q + D L K A + R AL L + L+ ++ + E +N++L
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 130 RETLEEYNKEFAEVKNQ----EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
R +E+ +V E + +AL++++ E L+ + + ++ KL+ +
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 186 KERKLQ-ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
+ K Q E + T E+ E K + L + + EL D + K A ++E+ +
Sbjct: 1570 QAMKAQFERDLQTRD--EQNEEKKRLLIKQVRELEAELED-ERKQRALAVASKKKMEIDL 1626
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 304
DLE + A A+ E +L + Q ++++A I ++ S E +L
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ--RELEEARASRDEIFAQSKES-EKKLK 1683
Query: 305 AKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYE 363
+ E EI QL E++ AS + R ++ + +L +++ S L +EK + +A
Sbjct: 1684 SLEAEILQLQEEL----ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA 1739
Query: 364 EVKKELNILKS-MEFAPSEGAGTQDAAKPLEV-LLLEKNRSLQSENAALRIS--NSDLSG 419
++++EL +S ME T L L E++ + +S+NA ++ N +L
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 420 RCAELQVRI-TEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEA 478
+ EL+ + ++ AT + I +LE+ L Q AA + + + +KE
Sbjct: 1800 KLQELEGAVKSKFKATISALEAKIGQLEEQLE-----QEAKERAAANKLVRRTEKKLKEI 1854
Query: 479 TALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELD 538
A Q + +++ ++ + + +E E E A + + LQ ELD
Sbjct: 1855 FMQVEDERRHAD------QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Query: 539 SLRADNIKLFEKIKFLQSYPGRG 561
N L ++ L++ RG
Sbjct: 1909 DATEANEGLSREVSTLKNRLRRG 1931
Score = 37.4 bits (85), Expect = 0.046
Identities = 66/314 (21%), Positives = 122/314 (38%), Gaps = 36/314 (11%)
Query: 300 EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQ 359
E EL AK+ E+ ++ E +++ L ++ +Q L KN +QL+ + +
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKH-------QQLLEEKNILAEQLQAETELF 903
Query: 360 ADYEEVKKELNILK-SMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLS 418
A+ EE++ L K +E + + + +L + + +Q+ L +
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 419 GRCAELQVRITEAVATATEQRELIARLEQDLS--IIQSIQRPDAEGAAEHRLEKIPEPIK 476
G +LQ+ A A + E I LE S I + D +L + E K
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 477 EATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSE 536
+ S ++ L R+ ++L+ E Q + LQ++
Sbjct: 1024 NLAKIRNKQEVMIS------DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 537 LDSLRADNIKLFEKIKFLQSYPGRGSGSDDTEL----------RYSSQYEERLDPF---- 582
+D L+ ++L +K + LQ RG DD L +Q E + F
Sbjct: 1078 IDELK---LQLAKKEEELQGALARG---DDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 583 SSFSKRERQRKYLS 596
+S +K E+Q++ LS
Sbjct: 1132 ASRNKAEKQKRDLS 1145
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 88.6 bits (218), Expect = 2e-17
Identities = 153/646 (23%), Positives = 275/646 (42%), Gaps = 78/646 (12%)
Query: 17 LQQLQRELDATATVLANRQDE--SEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK----- 69
LQ+L E D A + Q E S + L++++RE + E L ++ L +
Sbjct: 437 LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKR-----LIDVPDPVPALDLGQQLQLKVQRLHDIET 124
QG+ A ++ ++ E L V +R ++ + + L + + L+ + L
Sbjct: 497 QLQGD-SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR-EALESSHL 554
Query: 125 ENQKLRE-------TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEK-- 175
E + LR+ L + AE+ + E T+K +R L E +AL+K
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 176 --EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTAL---EKTRTELFDLKTKYD 230
+Q LQ L+E S S++E AE +LQ L EK R L++ T +
Sbjct: 615 LNQQLLQ---------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 231 EETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDV-- 287
+ + + DL + E Q++ R Q +A L QL + ++ +V
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
Query: 288 ----EQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLS 343
E+ V +++LEV L A ER+ L E +Q L+ +E S + + +QQ S
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ----GLSSAKELLESSLFEAQQQNS 781
Query: 344 AKNSTLKQLEEKLKGQADYEEV-KKELNILK-SMEFAPSEGAGTQD-AAKPLEVLLLEKN 400
T QLE +++ +EV + E+ LK ++ S+ +D AA+ L E
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 401 RSLQSENAALRISNSDLSGRCAELQVRITEAVATA-----TEQRELIARLEQDLSIIQSI 455
+L+ + AA + L + + + + +A A E+ EL RL++ + +++I
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 456 Q------RPDAEGA-AEHRLEKIPEPIK--EATALFYGPAAPASGALPEGQVDSLLSIIS 506
Q R AE A + +LE E + E A AS L + D + +
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
Query: 507 SQ------RERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGR 560
Q + + + +EL+ R + L ALQ E SL D + L ++++ L+S +
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS---Q 1018
Query: 561 GSGSDDTELRYSSQYEERLDPFSSFSK----RERQRKYLSLSPWDK 602
DD++ + +E+L +++ ER++ L+LS +K
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Score = 72.0 bits (175), Expect = 2e-12
Identities = 117/561 (20%), Positives = 237/561 (42%), Gaps = 67/561 (11%)
Query: 20 LQRELDATATVLANRQDESEQSRKRL--IEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
LQ L LA R++E E R ++ +E+ RE +K E L LK E+D
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD----LKKRNQEVDL 1474
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
++ +E E +V + L P+ + Q+L ++ +++ ++E + + R LE
Sbjct: 1475 QQEQIQELEKC-RSVLEHL-----PMAVQEREQKLTVQREQIRELEKDRETQRNVLEH-- 1526
Query: 138 KEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK------LQNDFAEKERKLQ 191
+ E++ ++ I++ + ++++ ++ L E +ALE E+ Q E E + +
Sbjct: 1527 -QLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 192 ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 251
+++ T + E + Q LQ +++ DL++ +T A E++ +++
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQ----SSQIHDLES----HSTVLARELQERDQEVKSQR 1636
Query: 252 QRAEVAQREAETLREQLSSANHSLQLASQ-IQKAPDVE-QAIEVLTRSSLEVELAAKERE 309
++ E QR+ E L + L + L L + IQ D + ++L +++L+ +ER
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERG 1696
Query: 310 IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 369
+L Q +Q + + S +Q LE K++E + + + +E+K +L
Sbjct: 1697 -RELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQL 1755
Query: 370 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRIT 429
+ G +LL ++ + + L+ + + LQ ++
Sbjct: 1756 E---------QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 430 EAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPA 489
EA + +A+ +Q+L +Q Q+ A+G E +KE G A
Sbjct: 1807 EA-------QRALAQRDQELEALQQEQQ-QAQGQEER--------VKEKADALQGALEQA 1850
Query: 490 SGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFE 549
L E + + +E+ R +EL E R +QAL+ L LRA++ + +
Sbjct: 1851 HMTLKERHGE-----LQDHKEQARRLEEELAVEGR----RVQALEEVLGDLRAESREQEK 1901
Query: 550 KIKFLQSYPGRGSGSDDTELR 570
+ LQ + + E R
Sbjct: 1902 ALLALQQQCAEQAQEHEVETR 1922
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/468 (21%), Positives = 203/468 (43%), Gaps = 31/468 (6%)
Query: 23 ELDATATVLANRQDESEQ---SRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALS 79
+L++ +TVLA E +Q S++ IE+ + K++ +DL ++ L+ Q E +
Sbjct: 1613 DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM--LQKERIQVL 1670
Query: 80 KRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKE 139
+ + + L I + +L Q QL +R + + ++ R +LE
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK-- 1728
Query: 140 FAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQND---FAEKERKLQETQMS 196
++++E ++ +E I E ++ LK+Q E +K+ +++E+++ Q
Sbjct: 1729 -LILRDKEKEVECQQEHIHELQE-LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ 1786
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 256
E+ E K QSLQ+ L++ + L + D+E A E + ER ++A+
Sbjct: 1787 LQEAREQGELKEQSLQSQLDEAQRAL----AQRDQELEALQQEQQQAQGQEERVKEKADA 1842
Query: 257 AQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVED 316
Q E L + LQ + + + E A+E +LE L E + +
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 317 VQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG-QADYEEVKKELNILKSM 375
+ LQ + + + L+ + LK+ +++L+ +A+ + + + ++
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARAR 1962
Query: 376 EFAPSEGAGTQDAA-KPLEVLLLEK---NRSLQSENAALRISNSDLSGRCAELQ--VRIT 429
A E G AA + E LLE+ +RSL++ A L+ S +L+ +RI
Sbjct: 1963 AEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQ 2022
Query: 430 EAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKE 477
E E ++ R ++D +Q +Q+ A+ E R ++ E + E
Sbjct: 2023 EG-----EIQDQDLRYQED---VQQLQQALAQRDEELRHQQEREQLLE 2062
Score = 64.3 bits (155), Expect = 4e-10
Identities = 123/584 (21%), Positives = 238/584 (40%), Gaps = 68/584 (11%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQ LQR+L + + + L+E E + LR+ +++ QGE
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMEL-HETMASLQSRLRRAELQRMEA-QGER 1343
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQ--------LQLKVQRLHDIETENQ 127
+ L + A ++ +++ A + ++ L+LK + ++E+E +
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE---EVESERE 1400
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQ---TLKNQAETIALEKEQKLQNDFA 184
+ + E+ + A+ K + + L + + E E+ TL+ Q + LEK++++Q
Sbjct: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE--LEKQREMQKAAL 1458
Query: 185 E----------KERKLQETQMSTTSK----LEEAEHKVQSLQTALEKTRTELFDLKTKYD 230
E +E LQ+ Q+ K LE VQ + L R ++ +L+ D
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK--D 1516
Query: 231 EETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANH-SLQLASQIQKAPDVEQ 289
ET E +++ +LE+ +Q E + + + L++QL + +L+L K ++
Sbjct: 1517 RETQRNVLEHQLL--ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574
Query: 290 AIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTL 349
I+ L E + A L E Q LQA +SQI LE + L
Sbjct: 1575 LIKEL-EGQRETQRVALTHLTLDLEERSQELQAQ--------SSQIHDLESHSTVLAREL 1625
Query: 350 KQLEEKLKGQADY-EEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 408
++ ++++K Q + EE++++ L TQD + + L+L+K R E+
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEHL------------TQDLERRDQELMLQKERIQVLEDQ 1673
Query: 409 ALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAA---- 464
R L ++++ + E T QR+L+ ++ QR E
Sbjct: 1674 RTR-QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR 1732
Query: 465 --EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAE 522
E +E E I E L G + SLL +S + + Q+L+
Sbjct: 1733 DKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL--LSQREQEIVVLQQQLQEA 1790
Query: 523 NRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDD 566
+ Q+LQS+LD + + ++++ LQ + G ++
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Score = 60.1 bits (144), Expect = 7e-09
Identities = 140/649 (21%), Positives = 252/649 (38%), Gaps = 105/649 (16%)
Query: 21 QRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA--- 77
Q+EL A + Q E ++ ++ E R+ K D Q A LL+ +
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQM-ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 78 --LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE- 134
S ++EA+AA L + RL + AL QQ + Q + + L++ L
Sbjct: 1138 LRASLWAQEAKAAQLQL--RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 135 --EYNKEFAEVKNQEVTIKALKEKIREYEQTLKN-------QAETIA---------LEKE 176
E E + + ++ L+ K AE +A L K
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT 1255
Query: 177 QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
Q+ ++ ++ +KL+E T ++ + ++Q LQ L + + E K+K++ + +
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE----KSKWEGKQNSL 1311
Query: 237 ADEIEMI---MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEV 293
E+ + M L+ +RAE+ + EA+ RE L +A +L + +A VE +
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
Query: 294 LTRSSLEVEL-------------AAKEREIAQLVEDVQRLQASLTK-LRENSA------- 332
LE +L ERE AQ +++ L+ + K L+EN A
Sbjct: 1372 SAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLA 1431
Query: 333 ----------SQISQLEQQLSAKNSTLKQLEEKLK--------GQADYEEVKKELNILKS 374
QI +LE+Q + + L+ L LK Q +E++K ++L+
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491
Query: 375 MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS---ENAALRISNSD-----LSGRCAELQV 426
+ A E + ++ LEK+R Q E+ L + D G+ +L+
Sbjct: 1492 LPMAVQEREQKLTVQRE-QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550
Query: 427 RITEAVATATEQRELIARLEQDLSIIQSI--QRPDAEGAAEHRLEKIPEPIKEATALFYG 484
++ A E E ++E +I+ + QR A H + E +E A
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA---- 1606
Query: 485 PAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADN 544
Q+ L S + + R+QE++++ + ++ LQ + + L D
Sbjct: 1607 ---------QSSQIHDLESHSTVLARELQERDQEVKSQ----REQIEELQRQKEHLTQD- 1652
Query: 545 IKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRK 593
L + + L R +D R + EE L+ S RER R+
Sbjct: 1653 --LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQI-KLSLRERGRE 1698
Score = 57.0 bits (136), Expect = 6e-08
Identities = 134/597 (22%), Positives = 245/597 (41%), Gaps = 105/597 (17%)
Query: 17 LQQLQREL-DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
L Q Q+EL DA+ + RQD Q K +++ + ++ ++++ + + ++
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKE--QETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ-KLRETLE 134
AL + S +++ K++ D+ + A D Q+L +E E Q KLRET +
Sbjct: 992 AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL---------VEQEVQEKLRET-Q 1041
Query: 135 EYNKEFAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQET 193
EYN+ E++ ++ ++ +L EK E + +A++I ++ L+ D
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEK--EQRLLVLQEADSIRQQELSALRQD----------- 1088
Query: 194 QMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM--IMTDLERAN 251
++EA+ + + L +E R E+ + + + + +E+E I RA+
Sbjct: 1089 -------MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRAS 1141
Query: 252 ---QRAEVAQ-----REAETLREQLSSANH-SLQLASQIQKA---PDVEQAIEVLTRSSL 299
Q A+ AQ R E+ E L++ Q +Q Q A ++QA+ + S
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201
Query: 300 EVELAAKEREIAQLVEDVQRLQASLTK--------LRENSASQISQLEQQLSAKNST--- 348
E+ +E Q SL K E AS + +L Q L T
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 349 ----LKQLEEKLKG-QADYEEVKKELNILKSM----EFAPSEGAGTQDAAKPLEVLLLEK 399
+++LEE+L +A+ +V EL L+ + S+ G Q++ + + L E
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 400 NRSLQS--------------ENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARL 445
SLQS E L+ + +L+ + LQ + EA A Q L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA----QASAAGIL 1377
Query: 446 EQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATAL-FYGPAAPASGALPEGQVDSLLSI 504
E+DL A A + + E++ + A AL G A G + + L
Sbjct: 1378 EEDLR--------TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQT 1429
Query: 505 ISSQRER---FRARNQELEAENRLAQHTLQALQSELD------SLRADNIKLFEKIK 552
++ + E R + QELE + + + L+ L +L L+ + I+ EK +
Sbjct: 1430 LAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Score = 44.3 bits (103), Expect = 4e-04
Identities = 112/464 (24%), Positives = 188/464 (40%), Gaps = 95/464 (20%)
Query: 16 DLQQLQRELDATATVLANRQDE--SEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
D+QQLQ+ LA R +E +Q R++L+E+S L ++V ++
Sbjct: 2036 DVQQLQQ-------ALAQRDEELRHQQEREQLLEKS----------LAQRVQ---ENMIQ 2075
Query: 74 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 133
E L + +E E L+ R +LQL L E E +LRET
Sbjct: 2076 EKQNLGQEREEEEIRGLHQSVR---------------ELQL---TLAQKEQEILELRETQ 2117
Query: 134 EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQET 193
+ N E ++ ++ K+ E L+ + E +LQ
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE-------------------RLQAA 2158
Query: 194 QMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM--TDLERAN 251
T ++ E K Q L +L +T+ + L+ E+ M + + LER +
Sbjct: 2159 LRQTEAREIEWREKAQDLALSLAQTKASVSSLQ------------EVAMFLQASVLERDS 2206
Query: 252 QRAEVAQREAETLREQLSSAN-HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREI 310
++ + Q E E R L HS S + EQ +++ S +E E + E
Sbjct: 2207 EQQRL-QDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEK 2265
Query: 311 AQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE---EKLKGQADYEEVKK 367
+ ++ LQ ++ +L E S++ + QL STL+Q+E KLK +A
Sbjct: 2266 QSWRQRLEHLQQAVARL-EIDRSRLQRHNVQL---RSTLEQVERERRKLKREAMRAAQAG 2321
Query: 368 ELNILKSMEFAPS--EGAGTQD------AAKPLEVLLLEKNRSLQSENAALRISNSDLSG 419
L I K+ +P+ +G G ++ A EV+LL+ +L+ + I+ S +
Sbjct: 2322 SLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381
Query: 420 R-CAELQVRITE---AVATATEQRELIARLEQ-DLSIIQSIQRP 458
R A L ++ AVA A E L A + D S+ QS+ P
Sbjct: 2382 RELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSP 2425
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 88.2 bits (217), Expect = 2e-17
Identities = 137/645 (21%), Positives = 266/645 (41%), Gaps = 110/645 (17%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSR--EFKKNTPEDLRKQVAPLLKSFQGEI 75
+QLQR++ N + E + R R +EQ+ E +K+ K L Q E
Sbjct: 2133 EQLQRDIQER-----NEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187
Query: 76 DALSKRSKEA---EAAFLNVYKRLIDVPDPVPALDLGQQLQLK--VQRLHDIETENQKLR 130
DA+ ++ KE E + L + + V L + ++Q K RL ++E EN+ +
Sbjct: 2188 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2247
Query: 131 ETLEEYNKEFAE-------------------VKNQEVTIKALKEKIREYEQTLKNQAETI 171
+ +E+ E ++ +EV I L E++ + +Q LK +
Sbjct: 2248 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2307
Query: 172 ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTK--- 228
+E++ +L D + L Q EE +++ L +EK + EL ++ K
Sbjct: 2308 VIEEKNELIRDLETQIECLMSDQECVKRNREE---EIEQLNEVIEKLQQELANIGQKTSM 2364
Query: 229 ----YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQ---- 280
EE + ++++++ + Q+ E A E ++ L N + +Q
Sbjct: 2365 NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFS 2424
Query: 281 ----------IQKAPD--VEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR 328
IQ P+ V AI+ L++ E+E+ E + L Q
Sbjct: 2425 LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN-----QTYFKSFE 2479
Query: 329 ENSASQIS-------QLEQQLSAKNSTLKQLEEKLK-----GQADYEEVKKEL-NILKSM 375
EN I QLE +SAK+ L Q +++K GQ + E ++K++ N+ K +
Sbjct: 2480 ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539
Query: 376 EFAPSEGAGTQDAAKPLE--VLLLEKNRSLQSENAALRISN----------SDLSG---R 420
E + +Q + ++ + N+++ SE I N SD+S R
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2599
Query: 421 CAELQVRITE---AVATATEQREL----IARLEQDLSIIQSIQRPDAEGAAEHRLEKIP- 472
+EL+ ++ E ++ EQ E+ + E+ L +Q + + + E ++ P
Sbjct: 2600 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2659
Query: 473 --EPIKEATALFYGPAAPASGALPEGQVDSLLSIIS-SQRERFRARNQELEAENRLAQHT 529
E +K T LF+ + SG E + S+ + ++ ++ + ++L+ E + +
Sbjct: 2660 DVEVLKTTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2717
Query: 530 LQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ 574
+ +LQ +L +R + EK+ L+ D+TE++ S +
Sbjct: 2718 MTSLQKDLSQVRDHLAEAKEKLSILEK-------EDETEVQESKK 2755
Score = 80.9 bits (198), Expect = 4e-15
Identities = 130/587 (22%), Positives = 246/587 (41%), Gaps = 111/587 (18%)
Query: 39 EQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLID 98
E+ R+RL E+SR R+Q+A L +G ID + + + F + D
Sbjct: 1897 EELRERLHEESRA---------REQLAVELSKAEGVIDGYA----DEKTLFERQIQEKTD 1943
Query: 99 VPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQ----EVTIKALK 154
+ D L Q+L RL ++E E Q+++E E +++ +K + E +
Sbjct: 1944 IIDR-----LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 155 EKIREYEQTLKNQAETIA--LEKEQK-LQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
EK+ + + ++ QAE + L+K+ K L+ D E+ + E + ++L + + Q+L
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQR----EAETLREQ 267
+ LEK R L DE+ + E ++ ++++ Q+ +V R RE
Sbjct: 2059 EKQLEKMRKFL-------DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111
Query: 268 LSSANH--------SLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVED--- 316
ANH S L S+ Q D+++ E + + +E +E E A LVED
Sbjct: 2112 EQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK----LEFRVRELEQALLVEDRKH 2167
Query: 317 ----------------------VQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE- 353
+ R + +T L E Q+ Q ++L KN ++QL
Sbjct: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE----QLEQFREELENKNEEVQQLHM 2223
Query: 354 ----EKLKGQADYEEVKKELNILK------SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL 403
+K + +E+++E + K + S+ TQD VL + + +
Sbjct: 2224 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ----HVLFGKFAQII 2279
Query: 404 QSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGA 463
Q + + N ++ + Q++IT E+ ELI LE + + S Q
Sbjct: 2280 QEKEVEIDQLNEQVTK--LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337
Query: 464 AE--HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSL---LSIISSQR----ERFRA 514
E +L ++ E +++ A + + +L E + DSL L ++ +++ ++
Sbjct: 2338 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQVET 2396
Query: 515 RNQELEAENRLAQHT---LQALQSELDSLRADNIKLFEKIKFLQSYP 558
N+E+ + + T + L EL SL+ + E ++ +QS P
Sbjct: 2397 ANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIP 2439
Score = 53.9 bits (128), Expect = 5e-07
Identities = 97/510 (19%), Positives = 212/510 (41%), Gaps = 87/510 (17%)
Query: 24 LDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL---LKSFQGEIDALSK 80
L A +L ++Q EQ L+E ++ K ED Q++ L +K ++ E D +
Sbjct: 264 LQAKQQILTHQQQLEEQDH--LLEDYQKKK----EDFTMQISFLQEKIKVYEMEQDKKVE 317
Query: 81 RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEF 140
S + E + + +I+ + + + L+LK + + T ++ L E E+ ++
Sbjct: 318 NSNKEE---IQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKN 370
Query: 141 AEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSK 200
E+KN ++ + K+K R+ + +K T+ E +++ D + +Q + T K
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVE-ELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 201 LEE---------AEHKVQSLQTALEKTRTELFDLKTKYDEE----------TTAKADEIE 241
LE+ + VQ Q + + ++ ++KT++ E T D+I+
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK 489
Query: 242 MIMTDLERANQRAE---------------------VAQREAETLREQLSSANHSLQ---- 276
++ + N + + QR+ E L E+LS + +Q
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 277 -LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ-------------RLQA 322
+A Q K + +++ + E+ A++ R+ +L + + A
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 323 SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 382
L ++ E+ +++ +L QL L EE+L + E++ +NI K + + G
Sbjct: 610 VLDRMAESQEAELERLRTQL------LFSHEEELSKLKEDLEIEHRINIEKLKD---NLG 660
Query: 383 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQREL- 441
+ L+ + +K ++Q E L + L ++L+ V + +E+ L
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
Query: 442 IARLEQDLSIIQSIQRPDAEGAAEHRLEKI 471
I L++++ I++ Q +G E ++++
Sbjct: 721 INELQKEIEILR--QEEKEKGTLEQEVQEL 748
Score = 53.1 bits (126), Expect = 8e-07
Identities = 122/614 (19%), Positives = 245/614 (39%), Gaps = 94/614 (15%)
Query: 14 RFDLQQLQRELDATATVLANRQD-ESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
+ L+ L++E +A +A Q+ E E+ R +L+ E EDL + ++ +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 73 GEIDALSKRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIE-----TE 125
D L K+ N + I+ + + QL L++ +L D++ ++
Sbjct: 657 ---DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 126 NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
++++ + E KE ++ +E L+++++E Q +T LEK+ K E
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL------QLKTELLEKQMK------E 761
Query: 186 KERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMT 245
KE LQE EAE+ + + +KT ++ + T +E +I
Sbjct: 762 KENDLQEKFAQL-----EAENSILKDE---KKTLEDMLKIHTPVSQEE-------RLIFL 806
Query: 246 DLERANQRAEVAQREAETLREQLSSANHS-LQLASQIQKAPDVEQAIEVLTRSSLEVELA 304
D ++ + V ++E E L E+ +QL +I+K + E + EV
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE----KNFEVNYQ 862
Query: 305 AKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 364
+ E A L++ L+ S K S++ L ++L + + K+K E+
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQR--INPTTVKMKSSVFDED 920
Query: 365 VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK---NRSLQSENAALRISNSDLSGRC 421
+ + +++E T + + LEV EK ++ L + L+ + ++S
Sbjct: 921 ---KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS--- 974
Query: 422 AELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATAL 481
+ E V + +++E ++ ++L II + +R E + + ++L
Sbjct: 975 -----FLNEEVKSLKQEKEQVSLRCRELEIIIN----------HNRAENVQSCDTQVSSL 1019
Query: 482 FYGPAAPASGALPEGQVDSLLSIISSQ-----RERFRARNQELEAENRLAQHTLQALQS- 535
G S EG V + + ++ N + E++ Q L L S
Sbjct: 1020 LDGVVTMTSRG-AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
Query: 536 -ELDSLRA----DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ-------YEERLDPFS 583
+ SLRA +N KL +++ L+ S +D L+ +Q Y +D
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLK------SEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 584 SFSKRERQRKYLSL 597
+ + E+ + SL
Sbjct: 1133 EYMENEKDKALCSL 1146
Score = 49.7 bits (117), Expect = 9e-06
Identities = 105/481 (21%), Positives = 193/481 (40%), Gaps = 78/481 (16%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF- 183
E+ +++ E + +E N TI +LK+ I + + L+ +AE + + +D+
Sbjct: 2961 EDHSIQQVSEPWLEERKAYIN---TISSLKDLITKMQ--LQREAEVYDSSQSHESFSDWR 3015
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E LQ+ + S L A ++ TAL T + L ++ + E +
Sbjct: 3016 GELLLALQQVFLEERSVLLAA---FRTELTALGTT--DAVGLLNCLEQRIQEQGVEYQAA 3070
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----L 299
M L++A++R+ ++ E + L Q++ +L+ + +K + + S +
Sbjct: 3071 MECLQKADRRSLLS--EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEM 3128
Query: 300 EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE------ 353
+VEL++ + +L E + + + +L+ A +LE L A++ LK+LE
Sbjct: 3129 QVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3188
Query: 354 ------------------------------EKLKGQADYEEVKKELNILK-SMEFAPSEG 382
EK K E K+EL LK S+E
Sbjct: 3189 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3248
Query: 383 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQV-------RITEAVATA 435
+ + LL E + ++S+ S+ GR ELQV RI E +T
Sbjct: 3249 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 436 TEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE 495
+REL A+L+ QS RP +E L+++ + ++E + +
Sbjct: 3309 DRERELHAQLQSSDGTGQS--RPPL--PSEDLLKELQKQLEEK----HSRIVELLNETEK 3360
Query: 496 GQVDSLLSIISSQRERFRAR-----NQELEAENRLAQHTLQA----LQSELDSLRADNIK 546
++DSL + +++R R QE E + H LQ+ LQ +L+ R K
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420
Query: 547 L 547
L
Sbjct: 3421 L 3421
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 54/397 (13%)
Query: 219 RTELFDLKTKYDEETTAKAD-EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQL 277
R E F + Y E+ + +EM+ ++L E RE E +R ++ LQ
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR--VTYGTEGLQQ 192
Query: 278 ASQIQKAPDVEQAIEVLTRSSLEVELAAKE-----REIAQLVEDVQRLQASLTKLREN-- 330
+ + A ++Q ++T+ + ++ A +E RE +L E Q+LQ +L+ +
Sbjct: 193 LQEFEAA--IKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250
Query: 331 --SASQISQLEQQLSAKNSTL---KQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGT 385
+++ S L AK L +QLEE+ DY++ K++ + S
Sbjct: 251 LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF---------- 300
Query: 386 QDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARL 445
+ ++V +E+++ +++ N + + EL +I E E ++ +
Sbjct: 301 --LQEKIKVYEMEQDKKVENSN---KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTA 355
Query: 446 EQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII 505
++ L +Q + +LE KE + ++ L+ +
Sbjct: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS--------------SEEIKQLMGTV 401
Query: 506 SSQRERFRARNQ-ELEAENRLAQHT---LQALQSELDSLRADNIKLFEKIKFLQSYPGRG 561
++R +Q E + R+ Q T L+ L++ELD + I ++ Q
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM---- 457
Query: 562 SGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLS 598
+ ++ + R+ + E L +S+ + E Q K ++++
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
Score = 43.9 bits (102), Expect = 5e-04
Identities = 73/370 (19%), Positives = 150/370 (40%), Gaps = 53/370 (14%)
Query: 30 VLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAF 89
+L Q + E+ R++E E +K + L+ + + + + K + + A
Sbjct: 3336 LLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR-----QQMEKDRQVHRKTLQTEQEAN 3390
Query: 90 LNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT 149
K++ ++ V DL +QL+ K Q+++ ++ E Q+L+ ++E+ K+ E + + +
Sbjct: 3391 TEGQKKMHELQSKVE--DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES 3448
Query: 150 IKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE-RKLQETQMSTTSKLEEAEHKV 208
+ L + + E T +QK++ + E KL E T E E
Sbjct: 3449 RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIR 3508
Query: 209 QSLQTALEKTR------TELFDLKTKYDEETTAKADEIEMIMTDLER------------- 249
Q LQ K + +E +T DE+ + I+ I+ L++
Sbjct: 3509 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3568
Query: 250 ------------ANQRAEVAQREAETLREQLSSANHSLQLASQIQ------KAPDVEQAI 291
Q AE+ ++ E+ N ++L QI+ D
Sbjct: 3569 PSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRF 3628
Query: 292 EVLTRSSLEVELAAKE----REIAQLVEDVQRLQASLTKLRENSASQISQLEQQLS--AK 345
+ +++E +A+++ RE L + ++R +A + KL+ + L Q LS ++
Sbjct: 3629 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN--DSLLQTLSPDSE 3686
Query: 346 NSTLKQLEEK 355
+ TLK++ K
Sbjct: 3687 HVTLKRIYGK 3696
Score = 42.7 bits (99), Expect = 0.001
Identities = 78/408 (19%), Positives = 159/408 (38%), Gaps = 62/408 (15%)
Query: 40 QSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNV---YKRL 96
+S+ + E+ E EDL++Q L + + + + S K E + + Y L
Sbjct: 812 KSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL 871
Query: 97 IDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEK 156
+ V D + Q+L+ K + L+ N+E + T+K +K
Sbjct: 872 LKVKDDLEDSKNKQELEYKSK---------------LKALNEELHLQRINPTTVK-MKSS 915
Query: 157 IREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHKVQSLQT 213
+ + ++T AET LE + ++ D E KL+ T+ + + +L + +++
Sbjct: 916 VFDEDKTFV--AET--LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG 971
Query: 214 ALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANH 273
+ E+ LK + E+ + + E+E+I+ N ++ Q + ++
Sbjct: 972 EISFLNEEVKSLKQE-KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 274 SLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS 333
+ S++ K+ E I V + S E +E + QL+ D + LR S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS 1090
Query: 334 QISQLEQQLSAKNST----------------------LKQLEEKLKGQAD---------- 361
+ +L+++L+ S + Q+ E ++ + D
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
Query: 362 ---YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 406
EE KEL + +E + T D KPL +L+ + +++ E
Sbjct: 1151 IFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198
Score = 40.4 bits (93), Expect = 0.005
Identities = 122/609 (20%), Positives = 226/609 (37%), Gaps = 107/609 (17%)
Query: 11 YWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREF--KKNTPEDLRKQVAPLL 68
Y+ L Q Q TV ++E + K L E +E + P D+ + +L
Sbjct: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE--- 125
+S+ + F + ++ I V ++D +QL L ++L D+ E
Sbjct: 1547 --------TISEEMFSKDKTF--IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVR 1596
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQA----ETIALEKEQ 177
+Q+ E L + + +++ Q + L+E+I+ + L ++ E + E+E+
Sbjct: 1597 QYQEHQQATELLRQAHMR--QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654
Query: 178 KL--------QNDFAEKERKLQETQMSTTS---------KLEEAEHKVQSLQT------- 213
L Q A +E+ E + S+T ++EE K + L
Sbjct: 1655 VLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714
Query: 214 --------ALEKTRTELFDLKTKYDEETTAKADEI------------------EMIMTDL 247
AL+K L + + + T A + I +I
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKE 307
A+ ++ V + E + S + S + I V + L++ + A E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
Query: 308 --REIAQLVEDVQ-RLQASLTKLRENSASQISQLEQ----QLSAKNSTLKQLEEKLKGQA 360
E +L+ ++ RLQA++ KL E + SQLE Q + +Q +E +
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
Query: 361 DYEEVKKELNILK------SMEFAPSEGA--GTQDAAKPLEVLLLEKNRSLQSENAALRI 412
EE+++ L+ ++E + +EG G D E + EK + L
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954
Query: 413 SNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIP 472
+++ L AE Q E+REL++R ++ + G E +L +
Sbjct: 1955 ASNRLQELEAEQQ--------QIQEERELLSRQKEAMKA--------EAGPVEQQLLQET 1998
Query: 473 EPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQA 532
E + + A L + QV +L + Q RF QE E + QA
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDL-QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA 2057
Query: 533 LQSELDSLR 541
L+ +L+ +R
Sbjct: 2058 LEKQLEKMR 2066
Score = 38.9 bits (89), Expect = 0.016
Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 68/488 (13%)
Query: 122 IETENQKLRETLEEYNKEFAEVKNQEVTI-KALKEK------IREYEQTLKNQAETIAL- 173
+E + +L E LE +E E+ + + + LK+K + E ++LK + E ++L
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993
Query: 174 --EKEQKLQNDFAEKERKLQETQMST------TSKLEEAEHKVQSLQTALEKTRTELFDL 225
E E + ++ AE + +TQ+S+ T AE V + + + + +
Sbjct: 994 CRELEIIINHNRAENVQSC-DTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
Query: 226 KTKYDEETTAKADEIEMIMTD----LERANQRAEVAQREAETLREQLS---SANHSLQLA 278
K ++ T + + E ++ D + + + E + L+++L+ S + L+L
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112
Query: 279 SQIQK-------APDVEQAIEVLTRS------SLEVELAAKEREIAQLVEDVQRLQASLT 325
+ Q+ + V+Q E + SL+ EL + E + ++ + +L+
Sbjct: 1113 MEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM 1172
Query: 326 KLRENSASQ------ISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAP 379
K +E I +L++ +S + S Q + G+ +K E+N E
Sbjct: 1173 KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNA----EDKE 1228
Query: 380 SEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQR 439
+ G + P + + Q L ++ + LQ R+++ T+
Sbjct: 1229 NSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
Query: 440 EL------IARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 493
+L + + E + I S + H+ + E T L
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL------------ 1336
Query: 494 PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSEL--DSLRADNIKLFEKI 551
E QV L S+ISS +++ + Q EAE Q LQA+ SL D++ + E
Sbjct: 1337 -EEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
Query: 552 KFLQSYPG 559
YPG
Sbjct: 1396 AQRTMYPG 1403
Score = 38.1 bits (87), Expect = 0.027
Identities = 112/591 (18%), Positives = 231/591 (39%), Gaps = 99/591 (16%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+L+ L+ E AT LA+ ++++E+ ++ L+ K+ L+K ++ +
Sbjct: 2682 ELEALRAESVATKAELASYKEKAEKLQEELL-----VKETNMTSLQKDLSQVRDHLAEAK 2736
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 135
+ LS KE E K + P P+ L + + + I + NQ + ++
Sbjct: 2737 EKLSILEKEDETEVQESKKACMFEPLPIK---LSKSIASQTDGTLKISSSNQTPQILVKN 2793
Query: 136 YNKEF---AEVKNQEVT--IKALKEKIREYEQT---------LKNQAETIALEKE----- 176
+ +E ++EVT I EKI + ++ ++ +ET L++E
Sbjct: 2794 AGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAV 2853
Query: 177 QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQT--------------ALEKTRTEL 222
Q L+ + + +Q + S + E H + QT + T ++
Sbjct: 2854 QLLKEECGTLKAVIQCLRSKEGSSIPELAHS-DAYQTREICSSDSGSDWGQGIYLTHSQG 2912
Query: 223 FDLKTK-YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQI 281
FD+ ++ EE+ + D + L RA E Q + T +HS+Q Q+
Sbjct: 2913 FDIASEGRGEESESATDSFPKKIKGLLRAVHN-EGMQVLSLTESPYSDGEDHSIQ---QV 2968
Query: 282 QKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR------------E 329
+ E+ + T SSL+ + + + V D + S + R E
Sbjct: 2969 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE 3028
Query: 330 NSASQISQLEQQLSAKNST-----LKQLEEKLKGQA-DYEEVKKEL------NILKSMEF 377
+ ++ +L+A +T L LE++++ Q +Y+ + L ++L ++
Sbjct: 3029 ERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQA 3088
Query: 378 APSEGAGT-------QDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE 430
++ G Q++ KP + LL + QS+ +++ S + R ELQ +++
Sbjct: 3089 LHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSS 3148
Query: 431 AVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPAS 490
E + +A+ + +L Q + RLE +K+ T
Sbjct: 3149 EKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE-----VKDKT----------- 3192
Query: 491 GALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR 541
+V L ++S++++ R LE E + + + EL+ L+
Sbjct: 3193 -----DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3238
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2282
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2340
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2341 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2388
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2446
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2504
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2564 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2618
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2677
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1475
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1476 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1638
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1817 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1864
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1865 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1190
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1243 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1281
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1399
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1455
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1456 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1625
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1686 QRELAEQELEKQ 1697
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2462
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2463 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2509
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2330 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1246
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1300
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1357
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1416
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2286
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2344
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2345 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2392
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2450
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2451 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2508
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2568 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2622
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2623 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2681
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1479
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1480 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1587
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1642
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1760
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1821 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1868
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1869 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1140 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1194
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1195 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1247 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1285
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1403
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1459
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1460 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1629
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1689
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1690 QRELAEQELEKQ 1701
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2018 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2066 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2121
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2122 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2181 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2419
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2466
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2467 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2513
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2334 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2448 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2686 LARREDVRHYLQGRSSIAGLLLKATNEKL 2714
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1078
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1079 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1133
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1250
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1304
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1361
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1420
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2282
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2340
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2341 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2388
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2446
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2504
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2564 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2618
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2619 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2677
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1475
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1476 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1638
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1817 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1864
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1865 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1190
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1243 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1281
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1399
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1455
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1456 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1625
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1685
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1686 QRELAEQELEKQ 1697
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2462
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2463 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2509
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2330 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1246
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1300
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1357
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1416
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2250
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2308
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2309 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2356
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2414
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2415 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2472
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2532 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2586
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2587 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2645
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1443
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1444 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1551
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1606
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1724
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1785 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1832
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1833 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1104 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1158
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1159 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1211 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1249
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1367
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1423
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1424 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1593
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1653
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1654 QRELAEQELEKQ 1665
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 1982 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2030 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2085
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2086 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2145 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2383
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2430
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2431 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2477
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2298 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2412 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2650 LARREDVRHYLQGRSSIAGLLLKATNEKL 2678
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 993 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1042
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1043 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1097
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1214
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1268
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1325
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1384
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2419
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2477
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2478 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2525
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2583
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2641
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2701 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2755
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2756 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2814
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1612
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1613 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1720
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1775
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1893
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1954 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 2001
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 2002 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1273 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1327
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1328 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1380 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1418
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1536
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1592
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1593 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1762
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1822
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1823 QRELAEQELEKQ 1834
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2151 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2199 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2254
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2255 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2314 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2552
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2599
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2600 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2646
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2467 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2581 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2819 LARREDVRHYLQGRSSIAGLLLKATNEKL 2847
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1211
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1212 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1266
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1383
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1437
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1494
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1553
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2208
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2260
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2318
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2319 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2366
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2424
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2482
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2542 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2596
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2655
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1453
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1454 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1561
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1616
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1734
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1795 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1842
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1843 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1114 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1168
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1169 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1221 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1259
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1377
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1433
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1434 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1603
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1663
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1664 QRELAEQELEKQ 1675
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 1992 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2040 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2095
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2096 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2155 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2393
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2440
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2441 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2487
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2308 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2422 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2660 LARREDVRHYLQGRSSIAGLLLKATNEKL 2688
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1052
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1053 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1107
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1224
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1278
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1335
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1394
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2157 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2216
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2268
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2326
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2327 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2374
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2432
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2433 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2490
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2550 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2604
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2605 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2663
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1461
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1462 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1569
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1624
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1742
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1803 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1850
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1851 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1957
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1122 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1176
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1177 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1229 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1267
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1385
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1441
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1442 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1611
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1671
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1672 QRELAEQELEKQ 1683
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2000 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2048 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2103
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2104 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2163 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2401
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2402 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2448
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2449 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2495
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2316 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2430 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2668 LARREDVRHYLQGRSSIAGLLLKATNEKL 2696
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1060
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1061 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1115
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1232
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1286
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1343
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1402
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 86.7 bits (213), Expect = 7e-17
Identities = 126/540 (23%), Positives = 235/540 (43%), Gaps = 56/540 (10%)
Query: 13 KRFDLQQLQR--ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLL 68
K+F Q L++ +++ T L + +E++ + L E+ + K E R+ QV L
Sbjct: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2257
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 128
S + +++ LSK EA + R D + + LQ + +++ + E +
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAAR 2309
Query: 129 LRETLEEYNK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF 183
L +E + + AE + + + K LKEK++ ++ + +AE L+++++L
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-- 2367
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E+ R+LQE + +L E + Q Q LE R ++ +A+A+ +++
Sbjct: 2368 -EQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLR 2415
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----- 298
+ ++ RA RAE + E++ H +LA+Q + + Q +E+ + S
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ--EKVTLVQTLEIQRQQSDHDAE 2473
Query: 299 -LEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 357
L +A ERE +L ++ + LQ +++ Q+ Q Q L + S L + + L+
Sbjct: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL--QQSFLSEKDSLLQ 2531
Query: 358 GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDL 417
+ E+ K +L L E A ++ ++ + + + E+ R + S A R +
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQL-REEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 418 SGRCAELQVRITEAVATATEQRELIA----RLEQDLSIIQSIQRPDAEGAAEHRLEKIPE 473
G Q + + +Q EL+A RL + L +++ R A H E
Sbjct: 2591 EG-VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR----AALAHSEEVTAS 2645
Query: 474 PIKEATALFYGPAA---PASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQ-HT 529
+ L G A PA+ A PE D L +S+QR + A E RLAQ HT
Sbjct: 2646 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQGHT 2704
Score = 84.7 bits (208), Expect = 3e-16
Identities = 138/591 (23%), Positives = 235/591 (39%), Gaps = 105/591 (17%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQQL++ +A A + + +E+SR R+ E+ R + R++ +GE+
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGEL 1502
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE---------- 125
AL R++EAEA + A L +Q+Q + QR E E
Sbjct: 1503 QALRARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 181
Q+ + LEE + E + + +A E+ R+ + L+ + E + K +
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RA 1610
Query: 182 DFAEK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
FAEK ER LQE ++ EEAE + Q Q E+ R E + E KA
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKA 1665
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLRE------------------------------- 266
+E + E Q+ +AQ EAE +E
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 267 QLSSANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQAS 323
QL+ +LA++ I+ + EQ + R LE ELA +RE A + Q L+A
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAE 1783
Query: 324 LTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVKKELNILKSM--EFAPS 380
L K+R ++ + ST ++ +++L+ +A + E+ +E L+++ E
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 381 EGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRE 440
+DAA+ E R L + AA+ G L+ A+ + E
Sbjct: 1844 RQLAEEDAARQ----RAEAERVLAEKLAAI--------GEATRLKTEAEIALKEKEAENE 1891
Query: 441 LIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE----- 495
+ RL +D ++ QR E A I E + + G + +
Sbjct: 1892 RLRRLAED----EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
Query: 496 GQVDSLLSIISSQRERFRARNQELEAE----NRLAQHTLQAL-QSELDSLR 541
QV+ + + + E+ A ELE E A+ TL++ Q+EL++ R
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1998
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/612 (20%), Positives = 232/612 (37%), Gaps = 82/612 (13%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R + Q DA L Q+ E+ ++R E+ E ++ R++VA LL+ +Q
Sbjct: 1163 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQA 1217
Query: 74 EIDALSKRSKEAE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQ 127
+ R +E E L Y+ D LG LQ +R I+ ++Q
Sbjct: 1218 VLAQTDVRQRELEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 128 KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE 187
+RE L + E++ EK+ E ++ K I K+
Sbjct: 1270 AVREQLRQEQALLEEIERHG-------EKVEECQRFAKQYINAI--------------KD 1308
Query: 188 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 247
+LQ + + K +Q+ E E DL+T Y E TT + I+ I L
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEV 301
R + +A+++ RE+L+ +L+ Q+ KA +A E+ R ++
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQE 1426
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD 361
E+ +E + + +Q L +LR++S ++I +Q A + ++EE+++
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR---- 1482
Query: 362 YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE---KNRSLQSENAALRISNSDLS 418
+ +E + G + + L E + R Q E LR D S
Sbjct: 1483 --------VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 419 GRCAELQVRI-----TEAVATATEQRELIARLEQDLSIIQSIQR---------PDAEGAA 464
R + +V + EA A +QR L A E L ++ +R + A
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
Query: 465 EHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENR 524
E ++ A F A +L E V ++ + + ER + E E
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREEAERRAQQQAEAERARE 1652
Query: 525 LAQHTLQALQ---SELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDP 581
A+ L+ Q +E LR ++ ++ Q+ + + E R + EE+
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR 1712
Query: 582 FSSFSKRERQRK 593
+++E +++
Sbjct: 1713 QRELAEQELEKQ 1724
Score = 68.9 bits (167), Expect = 1e-11
Identities = 131/643 (20%), Positives = 257/643 (39%), Gaps = 114/643 (17%)
Query: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 77
+A T+ + Q E E +R+R + E ++ E+ ++ A K+ E++
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 136
L + +EA +RL + + A +QLQL + ++ E + +++
Sbjct: 2041 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
+E + QE +++ +++R + + AE A E + + + A+ R+++E +
Sbjct: 2089 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2144
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 249
S E+A+ + Q+ Q A EK R E + + A + + ++E+
Sbjct: 2145 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 250 -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
Q+A+V Q E TLR QL +H L + + E RS +E EL +
Sbjct: 2204 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 309 EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 337
++ +L ++ QR LQ K+++ A+++ Q
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 338 LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 394
L ++ A+ L K L+EK++ + +K E +L+ E A + Q+ + +
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382
Query: 395 LLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE---AVATATEQRELIAR------- 444
L E+ + Q A R ++S L++R+ E A A A E + +
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2442
Query: 445 --------LEQDLSIIQS--IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ ++++Q+ IQR ++ AE E I E +E L
Sbjct: 2443 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL------------- 2489
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
Q LL + S + + + + +L Q T QALQ S ++ L ++ +F+
Sbjct: 2490 -QQEAKLLQLKSEEMQTVQ--------QEQLLQET-QALQ---QSFLSEKDSLLQRERFI 2536
Query: 555 QSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
+ + E+ + Q E ++ERQR S+
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/389 (19%), Positives = 164/389 (42%), Gaps = 56/389 (14%)
Query: 16 DLQQLQRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 69
+L Q Q+EL A A R Q++ EQ ++L E+++ F++ + ++Q+ A LK
Sbjct: 2357 ELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 126
E+ R++E F K+ ++ + + +L Q ++ + + +I+ +
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470
Query: 127 --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 174
++LRE + E +E E QE + LK + + Q + ET AL+
Sbjct: 2471 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
Query: 175 -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 211
K Q+L+ + +++++++ + + +EEA +
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589
Query: 212 QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 271
+ + + + EL L+ + ++ A+E + + L+ ++ A +E + +A
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649
Query: 272 NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 329
+L P E E + L +++A+ + A ++ E++QRL T + E
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708
Query: 330 NSASQISQ--LEQQLSAKNSTLKQLEEKL 356
+ + + L+ + S LK EKL
Sbjct: 2709 LARREDVRHYLQGRSSIAGLLLKATNEKL 2737
Score = 40.8 bits (94), Expect = 0.004
Identities = 87/462 (18%), Positives = 182/462 (39%), Gaps = 59/462 (12%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 184
E QK + +E K A + + + AL E A T+ E E L
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1101
Query: 185 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 244
E+ R L + KL+ ++ Q A E R LK + A E+E
Sbjct: 1102 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1156
Query: 245 TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV------EQAIEVLTR-S 297
L++ +AE Q + LR++L A + Q DV E+ ++L R
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
Query: 298 SLEVELAAKEREIAQL-----------------VEDVQRLQASLTKLRENSASQISQLEQ 340
++ + ++RE+ QL ++D +R Q + + + + +
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---PLADSQAVRE 1273
Query: 341 QLSAKNSTLKQLEEKLKGQADYEEVKKE-LNILKSMEF-APSEGAGTQDAAKPLEVLLLE 398
QL + + L+++E + + + K+ +N +K E + A + A P
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP------A 1327
Query: 399 KNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRP 458
K +QS + ++ DL +EL ++ + + E + R+E++ + + +
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS---ETLRRMEEEERLAEQQRAE 1384
Query: 459 DAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFR 513
+ E AE + ++ E +A A A + E V + + +Q+++ R
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK-R 1443
Query: 514 ARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
+ +EL+ + ++ +QA + ++ +++ E+I+ ++
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/466 (22%), Positives = 202/466 (43%), Gaps = 61/466 (13%)
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
+++ + +L++T E K E+K E L E+ ++ L+ + E A +E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
A K+++L+E ++LEE E + Q LQ +K ++ DL+ + +EE A+
Sbjct: 913 --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
LE+ A++ + E E L + N+ L ++ +E+ I LT + E
Sbjct: 968 ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKLSKERKL-----LEERISDLTTNLAE 1017
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLK 357
E AK +LTKL+ S IS+LE +L + + L++L+ KL+
Sbjct: 1018 EEEKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 358 GQA-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LL 397
G A D+ E KKE + ++ E A +A K + L +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 398 EKNRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS 454
+ L SE AA + DL L+ + + + + Q+EL A+ EQ++++++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 455 I---QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRE 510
+ E + +K + ++E T L A A+ + ++ + ++ +
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 511 RFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
QE+E + + + +Q LQS+ +L +K+ LQ+
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Score = 74.7 bits (182), Expect = 3e-13
Identities = 135/609 (22%), Positives = 257/609 (42%), Gaps = 77/609 (12%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIE----QSREFKKNTPEDLRKQVAPL---LK 69
L+QL+ E ++ L + + E++Q+ +R I Q + KK +D V L K
Sbjct: 1338 LRQLEEERNSLQDQL-DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKK 1395
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYK---RLIDVPDPVPALDLGQQLQL-----KVQRLHD 121
FQ EI+ L+++ +E AA+ + K RL D + +DL Q QL K QR D
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL-VVDLDNQRQLVSNLEKKQRKFD 1454
Query: 122 IETENQKLRETLEEYNKEFAEVKNQEVTIKAL------------KEKIREYEQTLKNQAE 169
+K + ++ AE + +E KAL KE++ + LK + E
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514
Query: 170 TIALEKEQKLQNDFA-EKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKT 227
+ K+ +N EK ++ ETQM ++LEE E ++Q+ + A + + LK
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 228 KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ-----LASQIQ 282
+++ + A+ ++ E L+R E + R ++A L+ L Q
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 283 KA-PDVEQAIEVLTRSSLEVELAAKEREIAQLVED------------VQRLQASLTKLRE 329
A E+AI+ L + +++ +E E A+ D + L+A L +L+E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 330 NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI-LKSMEFAPSEGAG---- 384
+ A+ +Q K ++L L G+ ++ K+ L + +E E G
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 385 --------TQDAAKPLEVLLLEKNRSLQSENAALRIS--NSDLSGRCAELQVRI-TEAVA 433
TQ A + L E++ + ++E+A ++ N +L + E++ + ++ +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 434 TATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 493
T IA+LE+ + Q + AA L++ + +KE A
Sbjct: 1815 TIAALEAKIAQLEEQVE-----QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869
Query: 494 PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKF 553
+ + + ++ ++ + + +E E E++ + LQ ELD N + ++
Sbjct: 1870 EQAEKGN------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 554 LQSYPGRGS 562
L+S RG+
Sbjct: 1924 LKSKLRRGN 1932
Score = 70.9 bits (172), Expect = 4e-12
Identities = 115/564 (20%), Positives = 233/564 (41%), Gaps = 82/564 (14%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
Q+L+ + + TVL DE +S + +++ R+ E+L +Q+ K + +D
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1224
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
+K++ E E A DL +L++ Q ++E + +KL ++E
Sbjct: 1225 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 138 KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
+ ++ + + K++ ++ + N+AE A+ KL D A +LQ+TQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1321
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
L+E + ++ T L + E L+ + DEE AK +
Sbjct: 1322 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 239 -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQ-LASQIQKAPDVEQAIEV 293
+++ + +E + + Q+E E L +Q ++A L+ +++Q+ D + +++
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD-DLVVDL 1436
Query: 294 LTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 353
+ L L K+R+ QL+ + + + + R+ + ++ + E + S + LE
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALE 1493
Query: 354 EKLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 408
E L+ + + E K L +++ S + + + + LE + E L+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 409 ALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRL 468
L+ + A+L++ + +R+L AR EQ+ + +QR H
Sbjct: 1554 ELQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEY 1601
Query: 469 EKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
E E ++ AL AA A L D L S+ + R +E + R Q
Sbjct: 1602 ETELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQA 1652
Query: 529 TLQALQSELDSLRADNIKLFEKIK 552
++ Q EL+ RA ++F K
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAK 1676
Score = 66.2 bits (160), Expect = 9e-11
Identities = 88/370 (23%), Positives = 172/370 (46%), Gaps = 33/370 (8%)
Query: 183 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
FA+++++L T M + A K+++ Q T+ + T+ +EE AK DE++
Sbjct: 806 FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 862
Query: 243 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE 302
+ Q+AE +E E QL+ + LQ Q+Q ++ E + V
Sbjct: 863 ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEAE-----EMRVR 912
Query: 303 LAAKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-E 354
LAAK++E+ +++ +++ RL+ L R+ A Q+ LE+QL + + ++L+ E
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 355 KLKGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRIS 413
K+ +A ++++ E+ ++ S E ++ L L E+ ++ ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLK 1029
Query: 414 NSDLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLE 469
N S +EL+VR+ + + E +L +LE D S I +Q AE + +L
Sbjct: 1030 NKHES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLA 1086
Query: 470 KIPEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
K E ++ A A A + AL + +++ +S + + RA + E + R
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 529 TLQALQSELD 538
L+AL++EL+
Sbjct: 1147 ELEALKTELE 1156
Score = 56.6 bits (135), Expect = 7e-08
Identities = 69/326 (21%), Positives = 142/326 (43%), Gaps = 25/326 (7%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
DL+ L+ + D+ + R++ +Q RK L Q ++F++ ED R + + +
Sbjct: 1625 DLKDLELQADSA---IKGREEAIKQLRK-LQAQMKDFQREL-EDARASRDEIFATAKEN- 1678
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQRLHDIETENQKLR 130
K++K EA + + + L DL ++L + + ++ E ++L
Sbjct: 1679 ---EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
+ + +E E ++ ++A+ +++R+ Q + + +A E+ +N+ A ++ +
Sbjct: 1736 ARIAQLEEELEE---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 191 QETQMSTTSKLEEAE----HKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTD 246
Q ++ SKL E E K +S ALE +L + + E A ++
Sbjct: 1793 QNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 247 LERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIEVLTRSSLEVELAA 305
L+ + E ++ AE +EQ N + QL Q+++A + Q I R L+ EL
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQRELDE 1909
Query: 306 KEREIAQLVEDVQRLQASLTKLRENS 331
+ +V L++ L + E S
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETS 1935
Score = 36.2 bits (82), Expect = 0.10
Identities = 44/211 (20%), Positives = 91/211 (43%), Gaps = 26/211 (12%)
Query: 283 KAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRE----------NSA 332
K DV A + + R L + AK ++ ++ +QR A+ KLR
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 844
Query: 333 SQISQLEQQLSAKNSTLKQLEEKLKG--------QADYEEVKKELNILKSMEFAPSEGAG 384
Q+++ E+++ AK L++ +E+ + + + ++ +E N+L+ A +E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE--- 901
Query: 385 TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIAR 444
A+ + V L K + L+ + + R +LQ E A + +L +
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQ 958
Query: 445 LEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 475
LE++ + Q +Q AE +++K+ + I
Sbjct: 959 LEEEEAARQKLQLEKV--TAEAKIKKLEDEI 987
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/466 (22%), Positives = 202/466 (43%), Gaps = 61/466 (13%)
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
+++ + +L++T E K E+K E L E+ ++ L+ + E A +E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
A K+++L+E ++LEE E + Q LQ +K ++ DL+ + +EE A+
Sbjct: 920 --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
LE+ A++ + E E L + N+ L ++ +E+ I LT + E
Sbjct: 975 ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKLSKERKL-----LEERISDLTTNLAE 1024
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLK 357
E AK +LTKL+ S IS+LE +L + + L++L+ KL+
Sbjct: 1025 EEEKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 358 GQA-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LL 397
G A D+ E KKE + ++ E A +A K + L +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 398 EKNRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS 454
+ L SE AA + DL L+ + + + + Q+EL A+ EQ++++++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 455 I---QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRE 510
+ E + +K + ++E T L A A+ + ++ + ++ +
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 511 RFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
QE+E + + + +Q LQS+ +L +K+ LQ+
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Score = 74.7 bits (182), Expect = 3e-13
Identities = 135/609 (22%), Positives = 257/609 (42%), Gaps = 77/609 (12%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIE----QSREFKKNTPEDLRKQVAPL---LK 69
L+QL+ E ++ L + + E++Q+ +R I Q + KK +D V L K
Sbjct: 1345 LRQLEEERNSLQDQL-DEEMEAKQNLERHISTLNIQLSDSKKKL-QDFASTVEALEEGKK 1402
Query: 70 SFQGEIDALSKRSKEAEAAFLNVYK---RLIDVPDPVPALDLGQQLQL-----KVQRLHD 121
FQ EI+ L+++ +E AA+ + K RL D + +DL Q QL K QR D
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL-VVDLDNQRQLVSNLEKKQRKFD 1461
Query: 122 IETENQKLRETLEEYNKEFAEVKNQEVTIKAL------------KEKIREYEQTLKNQAE 169
+K + ++ AE + +E KAL KE++ + LK + E
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521
Query: 170 TIALEKEQKLQNDFA-EKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKT 227
+ K+ +N EK ++ ETQM ++LEE E ++Q+ + A + + LK
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 228 KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ-----LASQIQ 282
+++ + A+ ++ E L+R E + R ++A L+ L Q
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 283 KA-PDVEQAIEVLTRSSLEVELAAKEREIAQLVED------------VQRLQASLTKLRE 329
A E+AI+ L + +++ +E E A+ D + L+A L +L+E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 330 NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI-LKSMEFAPSEGAG---- 384
+ A+ +Q K ++L L G+ ++ K+ L + +E E G
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 385 --------TQDAAKPLEVLLLEKNRSLQSENAALRIS--NSDLSGRCAELQVRI-TEAVA 433
TQ A + L E++ + ++E+A ++ N +L + E++ + ++ +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 434 TATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 493
T IA+LE+ + Q + AA L++ + +KE A
Sbjct: 1822 TIAALEAKIAQLEEQVE-----QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876
Query: 494 PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKF 553
+ + + ++ ++ + + +E E E++ + LQ ELD N + ++
Sbjct: 1877 EQAEKGN------ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 554 LQSYPGRGS 562
L+S RG+
Sbjct: 1931 LKSKLRRGN 1939
Score = 70.9 bits (172), Expect = 4e-12
Identities = 115/564 (20%), Positives = 233/564 (41%), Gaps = 82/564 (14%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
Q+L+ + + TVL DE +S + +++ R+ E+L +Q+ K + +D
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1231
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
+K++ E E A DL +L++ Q ++E + +KL ++E
Sbjct: 1232 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 138 KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
+ ++ + + K++ ++ + N+AE A+ KL D A +LQ+TQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1328
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
L+E + ++ T L + E L+ + DEE AK +
Sbjct: 1329 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 239 -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQ-LASQIQKAPDVEQAIEV 293
+++ + +E + + Q+E E L +Q ++A L+ +++Q+ D + +++
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD-DLVVDL 1443
Query: 294 LTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 353
+ L L K+R+ QL+ + + + + R+ + ++ + E + S + LE
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALE 1500
Query: 354 EKLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 408
E L+ + + E K L +++ S + + + + LE + E L+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 409 ALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRL 468
L+ + A+L++ + +R+L AR EQ+ + +QR H
Sbjct: 1561 ELQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEY 1608
Query: 469 EKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
E E ++ AL AA A L D L S+ + R +E + R Q
Sbjct: 1609 ETELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQA 1659
Query: 529 TLQALQSELDSLRADNIKLFEKIK 552
++ Q EL+ RA ++F K
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAK 1683
Score = 66.2 bits (160), Expect = 9e-11
Identities = 88/370 (23%), Positives = 172/370 (46%), Gaps = 33/370 (8%)
Query: 183 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
FA+++++L T M + A K+++ Q T+ + T+ +EE AK DE++
Sbjct: 813 FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 869
Query: 243 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE 302
+ Q+AE +E E QL+ + LQ Q+Q ++ E + V
Sbjct: 870 ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEAE-----EMRVR 919
Query: 303 LAAKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-E 354
LAAK++E+ +++ +++ RL+ L R+ A Q+ LE+QL + + ++L+ E
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 355 KLKGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRIS 413
K+ +A ++++ E+ ++ S E ++ L L E+ ++ ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLK 1036
Query: 414 NSDLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLE 469
N S +EL+VR+ + + E +L +LE D S I +Q AE + +L
Sbjct: 1037 NKHES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLA 1093
Query: 470 KIPEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
K E ++ A A A + AL + +++ +S + + RA + E + R
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 529 TLQALQSELD 538
L+AL++EL+
Sbjct: 1154 ELEALKTELE 1163
Score = 56.6 bits (135), Expect = 7e-08
Identities = 69/326 (21%), Positives = 142/326 (43%), Gaps = 25/326 (7%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
DL+ L+ + D+ + R++ +Q RK L Q ++F++ ED R + + +
Sbjct: 1632 DLKDLELQADSA---IKGREEAIKQLRK-LQAQMKDFQREL-EDARASRDEIFATAKEN- 1685
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQRLHDIETENQKLR 130
K++K EA + + + L DL ++L + + ++ E ++L
Sbjct: 1686 ---EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
+ + +E E ++ ++A+ +++R+ Q + + +A E+ +N+ A ++ +
Sbjct: 1743 ARIAQLEEELEE---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 191 QETQMSTTSKLEEAE----HKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTD 246
Q ++ SKL E E K +S ALE +L + + E A ++
Sbjct: 1800 QNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 247 LERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIEVLTRSSLEVELAA 305
L+ + E ++ AE +EQ N + QL Q+++A + Q I R L+ EL
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQRELDE 1916
Query: 306 KEREIAQLVEDVQRLQASLTKLRENS 331
+ +V L++ L + E S
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETS 1942
Score = 36.2 bits (82), Expect = 0.10
Identities = 44/211 (20%), Positives = 91/211 (43%), Gaps = 26/211 (12%)
Query: 283 KAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRE----------NSA 332
K DV A + + R L + AK ++ ++ +QR A+ KLR
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 851
Query: 333 SQISQLEQQLSAKNSTLKQLEEKLKG--------QADYEEVKKELNILKSMEFAPSEGAG 384
Q+++ E+++ AK L++ +E+ + + + ++ +E N+L+ A +E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE--- 908
Query: 385 TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIAR 444
A+ + V L K + L+ + + R +LQ E A + +L +
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQ 965
Query: 445 LEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 475
LE++ + Q +Q AE +++K+ + I
Sbjct: 966 LEEEEAARQKLQLEKV--TAEAKIKKLEDEI 994
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/466 (22%), Positives = 202/466 (43%), Gaps = 61/466 (13%)
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
+++ + +L++T E K E+K E L E+ ++ L+ + E A +E +++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
A K+++L+E ++LEE E + Q LQ +K ++ DL+ + +EE A+
Sbjct: 920 --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 974
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
LE+ A++ + E E L + N+ L ++ +E+ I LT + E
Sbjct: 975 ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKLSKERKL-----LEERISDLTTNLAE 1024
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLK 357
E AK +LTKL+ S IS+LE +L + + L++L+ KL+
Sbjct: 1025 EEEKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 358 GQA-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LL 397
G A D+ E KKE + ++ E A +A K + L +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Query: 398 EKNRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS 454
+ L SE AA + DL L+ + + + + Q+EL A+ EQ++++++
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 455 I---QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRE 510
+ E + +K + ++E T L A A+ + ++ + ++ +
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248
Query: 511 RFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
QE+E + + + +Q LQS+ +L +K+ LQ+
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Score = 70.9 bits (172), Expect = 4e-12
Identities = 115/564 (20%), Positives = 233/564 (41%), Gaps = 82/564 (14%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
Q+L+ + + TVL DE +S + +++ R+ E+L +Q+ K + +D
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1231
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
+K++ E E A DL +L++ Q ++E + +KL ++E
Sbjct: 1232 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 138 KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
+ ++ + + K++ ++ + N+AE A+ KL D A +LQ+TQ
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1328
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
L+E + ++ T L + E L+ + DEE AK +
Sbjct: 1329 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 239 -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQ-LASQIQKAPDVEQAIEV 293
+++ + +E + + Q+E E L +Q ++A L+ +++Q+ D + +++
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD-DLVVDL 1443
Query: 294 LTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 353
+ L L K+R+ QL+ + + + + R+ + ++ + E + S + LE
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALE 1500
Query: 354 EKLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 408
E L+ + + E K L +++ S + + + + LE + E L+
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 409 ALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRL 468
L+ + A+L++ + +R+L AR EQ+ + +QR H
Sbjct: 1561 ELQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEY 1608
Query: 469 EKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
E E ++ AL AA A L D L S+ + R +E + R Q
Sbjct: 1609 ETELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQA 1659
Query: 529 TLQALQSELDSLRADNIKLFEKIK 552
++ Q EL+ RA ++F K
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAK 1683
Score = 66.2 bits (160), Expect = 9e-11
Identities = 88/370 (23%), Positives = 172/370 (46%), Gaps = 33/370 (8%)
Query: 183 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
FA+++++L T M + A K+++ Q T+ + T+ +EE AK DE++
Sbjct: 813 FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 869
Query: 243 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE 302
+ Q+AE +E E QL+ + LQ Q+Q ++ E + V
Sbjct: 870 ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEAE-----EMRVR 919
Query: 303 LAAKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-E 354
LAAK++E+ +++ +++ RL+ L R+ A Q+ LE+QL + + ++L+ E
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 979
Query: 355 KLKGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRIS 413
K+ +A ++++ E+ ++ S E ++ L L E+ ++ ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLK 1036
Query: 414 NSDLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLE 469
N S +EL+VR+ + + E +L +LE D S I +Q AE + +L
Sbjct: 1037 NKHES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLA 1093
Query: 470 KIPEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
K E ++ A A A + AL + +++ +S + + RA + E + R
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 529 TLQALQSELD 538
L+AL++EL+
Sbjct: 1154 ELEALKTELE 1163
Score = 66.2 bits (160), Expect = 9e-11
Identities = 102/481 (21%), Positives = 200/481 (41%), Gaps = 71/481 (14%)
Query: 22 RELDATATVLANRQDESEQSRKRLIEQSREFKK------NTPEDLRKQVAPLLKSFQGEI 75
RE + A LA +E+ ++++ L ++ K ++ +D+ K V L KS +
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR--- 1542
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-------ETENQK 128
AL + +E + + L D L++ Q LK Q D+ E + ++
Sbjct: 1543 -ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA-LKGQFERDLQARDEQNEEKRRQ 1600
Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 188
L+ L EY E + + Q A K+K+ + L+ QA++ +E+ ++ + R
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-----QLR 1655
Query: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
KLQ +LE+A +R E+F + +++ + ++ + DL
Sbjct: 1656 KLQAQMKDFQRELEDAR-----------ASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
A + + A E E L E+L+S+ + R++L+ E E
Sbjct: 1705 AAERARKQADLEKEELAEELASS---------------------LSGRNALQDEKRRLEA 1743
Query: 309 EIAQLVEDVQRLQASLTKLRE---NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEV 365
IAQL E+++ Q ++ + + + Q QL +L+ + ST ++ E + E
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQ 1800
Query: 366 KKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS-ENAALRISNSDLSGRCAE 423
KEL + L ME A + AA ++ LE+ ++ E A S + E
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHR-----LEKIPEPIKEA 478
+ +++ + A + +E + E+ + ++ ++R E E + K+ + EA
Sbjct: 1861 ILLQVEDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 479 T 479
T
Sbjct: 1918 T 1918
Score = 54.3 bits (129), Expect = 4e-07
Identities = 67/319 (21%), Positives = 139/319 (43%), Gaps = 25/319 (7%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
DL+ L+ + D+ + R++ +Q RK L Q ++F++ ED R + + +
Sbjct: 1632 DLKDLELQADSA---IKGREEAIKQLRK-LQAQMKDFQREL-EDARASRDEIFATAKEN- 1685
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQRLHDIETENQKLR 130
K++K EA + + + L DL ++L + + ++ E ++L
Sbjct: 1686 ---EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
+ + +E E ++ ++A+ +++R+ Q + + +A E+ +N+ A ++ +
Sbjct: 1743 ARIAQLEEELEE---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 191 QETQMSTTSKLEEAE----HKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTD 246
Q ++ SKL E E K +S ALE +L + + E A ++
Sbjct: 1800 QNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 247 LERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIEVLTRSSLEVELAA 305
L+ + E ++ AE +EQ N + QL Q+++A + Q I R L+ EL
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQRELDE 1916
Query: 306 KEREIAQLVEDVQRLQASL 324
+ +V L++ L
Sbjct: 1917 ATESNEAMGREVNALKSKL 1935
Score = 36.2 bits (82), Expect = 0.10
Identities = 44/211 (20%), Positives = 91/211 (43%), Gaps = 26/211 (12%)
Query: 283 KAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRE----------NSA 332
K DV A + + R L + AK ++ ++ +QR A+ KLR
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 851
Query: 333 SQISQLEQQLSAKNSTLKQLEEKLKG--------QADYEEVKKELNILKSMEFAPSEGAG 384
Q+++ E+++ AK L++ +E+ + + + ++ +E N+L+ A +E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE--- 908
Query: 385 TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIAR 444
A+ + V L K + L+ + + R +LQ E A + +L +
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQ 965
Query: 445 LEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 475
LE++ + Q +Q AE +++K+ + I
Sbjct: 966 LEEEEAARQKLQLEKV--TAEAKIKKLEDEI 994
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/466 (22%), Positives = 202/466 (43%), Gaps = 61/466 (13%)
Query: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 180
+++ + +L++T E K E+K E L E+ ++ L+ + E A +E +++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 181 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 240
A K+++L+E ++LEE E + Q LQ +K ++ DL+ + +EE A+
Sbjct: 913 --LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ--- 967
Query: 241 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE 300
LE+ A++ + E E L + N+ L ++ +E+ I LT + E
Sbjct: 968 ---KLQLEKVTAEAKIKKLEDEIL--VMDDQNNKLSKERKL-----LEERISDLTTNLAE 1017
Query: 301 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNST---LKQLEEKLK 357
E AK +LTKL+ S IS+LE +L + + L++L+ KL+
Sbjct: 1018 EEEKAK----------------NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 358 GQA-DYEE----------------VKKELNILKSMEFAPSEGAGTQDAAKPLEVL---LL 397
G A D+ E KKE + ++ E A +A K + L +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Query: 398 EKNRSLQSENAALRISNS---DLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS 454
+ L SE AA + DL L+ + + + + Q+EL A+ EQ++++++
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 455 I---QRPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSLLSIISSQRE 510
+ E + +K + ++E T L A A+ + ++ + ++ +
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241
Query: 511 RFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
QE+E + + + +Q LQS+ +L +K+ LQ+
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Score = 70.9 bits (172), Expect = 4e-12
Identities = 115/564 (20%), Positives = 233/564 (41%), Gaps = 82/564 (14%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 77
Q+L+ + + TVL DE +S + +++ R+ E+L +Q+ K + +D
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ-FKRAKANLDK 1224
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
+K++ E E A DL +L++ Q ++E + +KL ++E
Sbjct: 1225 -NKQTLEKENA------------------DLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 138 KEFAEVKNQEVTIKALKEKIREYEQT---LKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
+ ++ + + K++ ++ + N+AE A+ KL D A +LQ+TQ
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQ 1321
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD---------------- 238
L+E + ++ T L + E L+ + DEE AK +
Sbjct: 1322 ----ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 239 -EIEMIMTDLERANQRAEVAQREAETLREQL---SSANHSLQ-LASQIQKAPDVEQAIEV 293
+++ + +E + + Q+E E L +Q ++A L+ +++Q+ D + +++
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD-DLVVDL 1436
Query: 294 LTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 353
+ L L K+R+ QL+ + + + + R+ + ++ + E + S + LE
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALE 1493
Query: 354 EKLKGQADYEEVKKEL-----NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 408
E L+ + + E K L +++ S + + + + LE + E L+
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 409 ALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRL 468
L+ + A+L++ + +R+L AR EQ+ + +QR H
Sbjct: 1554 ELQATED------AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR------QLHEY 1601
Query: 469 EKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
E E ++ AL AA A L D L S+ + R +E + R Q
Sbjct: 1602 ETELEDERKQRAL----AAAAKKKLEGDLKDLELQADSAIKGR-----EEAIKQLRKLQA 1652
Query: 529 TLQALQSELDSLRADNIKLFEKIK 552
++ Q EL+ RA ++F K
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAK 1676
Score = 66.2 bits (160), Expect = 9e-11
Identities = 88/370 (23%), Positives = 172/370 (46%), Gaps = 33/370 (8%)
Query: 183 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
FA+++++L T M + A K+++ Q T+ + T+ +EE AK DE++
Sbjct: 806 FAKRQQQL--TAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ- 862
Query: 243 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE 302
+ Q+AE +E E QL+ + LQ Q+Q ++ E + V
Sbjct: 863 ---KTKERQQKAENELKELEQKHSQLTEEKNLLQ--EQLQAETELYAEAE-----EMRVR 912
Query: 303 LAAKEREIAQLVEDVQ-RLQ------ASLTKLRENSASQISQLEQQLSAKNSTLKQLE-E 354
LAAK++E+ +++ +++ RL+ L R+ A Q+ LE+QL + + ++L+ E
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE 972
Query: 355 KLKGQADYEEVKKELNILKSMEFAPS-EGAGTQDAAKPLEVLLLEKNRSLQSENAALRIS 413
K+ +A ++++ E+ ++ S E ++ L L E+ ++ ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN---LTKLK 1029
Query: 414 NSDLSGRCAELQVRITEAVATATEQRELIARLEQDLS----IIQSIQRPDAEGAAEHRLE 469
N S +EL+VR+ + + E +L +LE D S I +Q AE + +L
Sbjct: 1030 NKHES-MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE--LKMQLA 1086
Query: 470 KIPEPIKEATALFYGPAAPASGALPE-GQVDSLLSIISSQRERFRARNQELEAENRLAQH 528
K E ++ A A A + AL + +++ +S + + RA + E + R
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 529 TLQALQSELD 538
L+AL++EL+
Sbjct: 1147 ELEALKTELE 1156
Score = 66.2 bits (160), Expect = 9e-11
Identities = 102/481 (21%), Positives = 200/481 (41%), Gaps = 71/481 (14%)
Query: 22 RELDATATVLANRQDESEQSRKRLIEQSREFKK------NTPEDLRKQVAPLLKSFQGEI 75
RE + A LA +E+ ++++ L ++ K ++ +D+ K V L KS +
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR--- 1535
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-------ETENQK 128
AL + +E + + L D L++ Q LK Q D+ E + ++
Sbjct: 1536 -ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA-LKGQFERDLQARDEQNEEKRRQ 1593
Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 188
L+ L EY E + + Q A K+K+ + L+ QA++ +E+ ++ + R
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK-----QLR 1648
Query: 189 KLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLE 248
KLQ +LE+A +R E+F + +++ + ++ + DL
Sbjct: 1649 KLQAQMKDFQRELEDAR-----------ASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 308
A + + A E E L E+L+S+ + R++L+ E E
Sbjct: 1698 AAERARKQADLEKEELAEELASS---------------------LSGRNALQDEKRRLEA 1736
Query: 309 EIAQLVEDVQRLQASLTKLRE---NSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEV 365
IAQL E+++ Q ++ + + + Q QL +L+ + ST ++ E + E
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQ 1793
Query: 366 KKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS-ENAALRISNSDLSGRCAE 423
KEL + L ME A + AA ++ LE+ ++ E A S + E
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHR-----LEKIPEPIKEA 478
+ +++ + A + +E + E+ + ++ ++R E E + K+ + EA
Sbjct: 1854 ILLQVEDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 479 T 479
T
Sbjct: 1911 T 1911
Score = 54.3 bits (129), Expect = 4e-07
Identities = 67/319 (21%), Positives = 139/319 (43%), Gaps = 25/319 (7%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
DL+ L+ + D+ + R++ +Q RK L Q ++F++ ED R + + +
Sbjct: 1625 DLKDLELQADSA---IKGREEAIKQLRK-LQAQMKDFQREL-EDARASRDEIFATAKEN- 1678
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQRLHDIETENQKLR 130
K++K EA + + + L DL ++L + + ++ E ++L
Sbjct: 1679 ---EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
+ + +E E ++ ++A+ +++R+ Q + + +A E+ +N+ A ++ +
Sbjct: 1736 ARIAQLEEELEE---EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 191 QETQMSTTSKLEEAE----HKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTD 246
Q ++ SKL E E K +S ALE +L + + E A ++
Sbjct: 1793 QNKELR--SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 247 LERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIEVLTRSSLEVELAA 305
L+ + E ++ AE +EQ N + QL Q+++A + Q I R L+ EL
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQRELDE 1909
Query: 306 KEREIAQLVEDVQRLQASL 324
+ +V L++ L
Sbjct: 1910 ATESNEAMGREVNALKSKL 1928
Score = 36.2 bits (82), Expect = 0.10
Identities = 44/211 (20%), Positives = 91/211 (43%), Gaps = 26/211 (12%)
Query: 283 KAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRE----------NSA 332
K DV A + + R L + AK ++ ++ +QR A+ KLR
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 844
Query: 333 SQISQLEQQLSAKNSTLKQLEEKLKG--------QADYEEVKKELNILKSMEFAPSEGAG 384
Q+++ E+++ AK L++ +E+ + + + ++ +E N+L+ A +E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE--- 901
Query: 385 TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIAR 444
A+ + V L K + L+ + + R +LQ E A + +L +
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQ 958
Query: 445 LEQDLSIIQSIQRPDAEGAAEHRLEKIPEPI 475
LE++ + Q +Q AE +++K+ + I
Sbjct: 959 LEEEEAARQKLQLEKV--TAEAKIKKLEDEI 987
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 85.5 bits (210), Expect = 1e-16
Identities = 136/653 (20%), Positives = 266/653 (40%), Gaps = 118/653 (18%)
Query: 18 QQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLR----------KQVAPL 67
+QLQR++ N + E + R R +EQ+ +T + + K L
Sbjct: 2133 EQLQRDIQER-----NEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSL 2187
Query: 68 LKSFQGEIDALSKRSKEA---EAAFLNVYKRLIDVPDPVPALDLGQQLQLK--VQRLHDI 122
Q E DA+ ++ KE E + L + + V L + ++Q K RL ++
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 123 ETENQKLRETLEEYNKEFAE-------------------VKNQEVTIKALKEKIREYEQT 163
E EN+ ++ +E+ E ++ +EV I L E++ + +Q
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
Query: 164 LKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF 223
LK + +E++ +L D + L Q EE +++ L +EK + EL
Sbjct: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE---EIEQLNEVIEKLQQELA 2364
Query: 224 DLKTK-------YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQ 276
++ K EE + ++++++ + Q+ E A E ++ L N +
Sbjct: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
Query: 277 LASQ--------------IQKAPD--VEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRL 320
+Q IQ P+ V AI+ L++ E+E+ E + L
Sbjct: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLEN----- 2479
Query: 321 QASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK-----GQADYEEVKKE 368
Q EN I QLE +SAK+ L Q +++K GQ + E ++K+
Sbjct: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Query: 369 L-NILKSMEFAPSEGAGTQDAAKPLE--VLLLEKNRSLQSENAALRISN----------S 415
+ N+ K +E + +Q + ++ + N+++ SE I N S
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
Query: 416 DLSG---RCAELQVRITE---AVATATEQREL----IARLEQDLSIIQSIQRPDAEGAAE 465
D+S R +EL+ ++ E ++ EQ E+ + E+ L +Q + + + E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
Query: 466 HRLEKIP---EPIKEATALFYGPAAPASGALPEGQVDSLLSIIS-SQRERFRARNQELEA 521
++ P E +K T LF+ + SG E + S+ + ++ ++ + ++L+
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFH--SNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2717
Query: 522 ENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ 574
E + + + +LQ +L +R + EK+ L+ D+TE++ S +
Sbjct: 2718 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK-------EDETEVQESKK 2763
Score = 79.7 bits (195), Expect = 8e-15
Identities = 121/566 (21%), Positives = 236/566 (41%), Gaps = 87/566 (15%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID 76
+ +L++EL + L + E +Q I++ RE E ++ + P+ + E +
Sbjct: 1945 IDRLEQELLCASNRLQELEAEQQQ-----IQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999
Query: 77 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 136
L K E + V D+ V AL++ D+E + + E +E
Sbjct: 2000 KLMKEKLEVQCQAEKVRD---DLQKQVKALEI------------DVEEQVSRFIELEQEK 2044
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
N E +++ Q ++ EK+R++ + A+++E + D ++E + E Q+
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKF-------LDEQAIDREH--ERDVFQQEIQKLEQQLK 2095
Query: 197 TTSKLEE-AEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAE 255
+ + +EH+ + + E+ L + K E +K E + D++ N+ E
Sbjct: 2096 VVPRFQPISEHQTREV----EQLANHLKEKTDKCSELLLSK----EQLQRDIQERNEEIE 2147
Query: 256 VAQREAETLREQLSSANHSLQLASQIQKAPDVEQ--AIEVLTRSSLEVELAA-------K 306
+ L + L L A QK D + A+E SLEV+L A K
Sbjct: 2148 KLEFRVRELEQAL------LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2201
Query: 307 EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQL--SAKNSTLKQLEEKLKGQADYEE 364
E+EI L E +++ + L EN ++ QL QL K ST + E + + + ++
Sbjct: 2202 EKEITNLEEQLEQFREEL----ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDD 2257
Query: 365 VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAEL 424
++K + S+ TQD VL + + +Q + + N ++ +
Sbjct: 2258 MEK-----LGLAIKESDAMSTQDQ----HVLFGKFAQIIQEKEVEIDQLNEQVTK--LQQ 2306
Query: 425 QVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAE--HRLEKIPEPIKEATALF 482
Q++IT E+ ELI LE + + S Q E +L ++ E +++ A
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2366
Query: 483 YGPAAPASGALPEGQVDSL---LSIISSQR----ERFRARNQELEAENRLAQHT---LQA 532
+ + +L E + DSL L ++ +++ ++ N+E+ + + T +
Sbjct: 2367 GQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
Query: 533 LQSELDSLRADNIKLFEKIKFLQSYP 558
L EL SL+ + E ++ +QS P
Sbjct: 2426 LTQELFSLKRER----ESVEKIQSIP 2447
Score = 53.9 bits (128), Expect = 5e-07
Identities = 97/510 (19%), Positives = 212/510 (41%), Gaps = 87/510 (17%)
Query: 24 LDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL---LKSFQGEIDALSK 80
L A +L ++Q EQ L+E ++ K ED Q++ L +K ++ E D +
Sbjct: 264 LQAKQQILTHQQQLEEQDH--LLEDYQKKK----EDFTMQISFLQEKIKVYEMEQDKKVE 317
Query: 81 RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEF 140
S + E + + +I+ + + + L+LK + + T ++ L E E+ ++
Sbjct: 318 NSNKEE---IQEKETIIEELNTKIIEEEKKTLELKDK----LTTADKLLGELQEQIVQKN 370
Query: 141 AEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSK 200
E+KN ++ + K+K R+ + +K T+ E +++ D + +Q + T K
Sbjct: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVE-ELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 201 LEE---------AEHKVQSLQTALEKTRTELFDLKTKYDEE----------TTAKADEIE 241
LE+ + VQ Q + + ++ ++KT++ E T D+I+
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK 489
Query: 242 MIMTDLERANQRAE---------------------VAQREAETLREQLSSANHSLQ---- 276
++ + N + + QR+ E L E+LS + +Q
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 277 -LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ-------------RLQA 322
+A Q K + +++ + E+ A++ R+ +L + + A
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 323 SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 382
L ++ E+ +++ +L QL L EE+L + E++ +NI K + + G
Sbjct: 610 VLDRMAESQEAELERLRTQL------LFSHEEELSKLKEDLEIEHRINIEKLKD---NLG 660
Query: 383 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQREL- 441
+ L+ + +K ++Q E L + L ++L+ V + +E+ L
Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720
Query: 442 IARLEQDLSIIQSIQRPDAEGAAEHRLEKI 471
I L++++ I++ Q +G E ++++
Sbjct: 721 INELQKEIEILR--QEEKEKGTLEQEVQEL 748
Score = 53.1 bits (126), Expect = 8e-07
Identities = 122/614 (19%), Positives = 245/614 (39%), Gaps = 94/614 (15%)
Query: 14 RFDLQQLQRELDATATVLANRQD-ESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ 72
+ L+ L++E +A +A Q+ E E+ R +L+ E EDL + ++ +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 73 GEIDALSKRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIE-----TE 125
D L K+ N + I+ + + QL L++ +L D++ ++
Sbjct: 657 ---DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713
Query: 126 NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAE 185
++++ + E KE ++ +E L+++++E Q +T LEK+ K E
Sbjct: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQEL------QLKTELLEKQMK------E 761
Query: 186 KERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMT 245
KE LQE EAE+ + + +KT ++ + T +E +I
Sbjct: 762 KENDLQEKFAQL-----EAENSILKDE---KKTLEDMLKIHTPVSQEE-------RLIFL 806
Query: 246 DLERANQRAEVAQREAETLREQLSSANHS-LQLASQIQKAPDVEQAIEVLTRSSLEVELA 304
D ++ + V ++E E L E+ +QL +I+K + E + EV
Sbjct: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE----KNFEVNYQ 862
Query: 305 AKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 364
+ E A L++ L+ S K S++ L ++L + + K+K E+
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQR--INPTTVKMKSSVFDED 920
Query: 365 VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK---NRSLQSENAALRISNSDLSGRC 421
+ + +++E T + + LEV EK ++ L + L+ + ++S
Sbjct: 921 ---KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS--- 974
Query: 422 AELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATAL 481
+ E V + +++E ++ ++L II + +R E + + ++L
Sbjct: 975 -----FLNEEVKSLKQEKEQVSLRCRELEIIIN----------HNRAENVQSCDTQVSSL 1019
Query: 482 FYGPAAPASGALPEGQVDSLLSIISSQ-----RERFRARNQELEAENRLAQHTLQALQS- 535
G S EG V + + ++ N + E++ Q L L S
Sbjct: 1020 LDGVVTMTSRG-AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078
Query: 536 -ELDSLRA----DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQ-------YEERLDPFS 583
+ SLRA +N KL +++ L+ S +D L+ +Q Y +D
Sbjct: 1079 TKESSLRATQPSENDKLQKELNVLK------SEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132
Query: 584 SFSKRERQRKYLSL 597
+ + E+ + SL
Sbjct: 1133 EYMENEKDKALCSL 1146
Score = 49.7 bits (117), Expect = 9e-06
Identities = 105/481 (21%), Positives = 193/481 (40%), Gaps = 78/481 (16%)
Query: 125 ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDF- 183
E+ +++ E + +E N TI +LK+ I + + L+ +AE + + +D+
Sbjct: 2969 EDHSIQQVSEPWLEERKAYIN---TISSLKDLITKMQ--LQREAEVYDSSQSHESFSDWR 3023
Query: 184 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 243
E LQ+ + S L A ++ TAL T + L ++ + E +
Sbjct: 3024 GELLLALQQVFLEERSVLLAA---FRTELTALGTT--DAVGLLNCLEQRIQEQGVEYQAA 3078
Query: 244 MTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS----L 299
M L++A++R+ ++ E + L Q++ +L+ + +K + + S +
Sbjct: 3079 MECLQKADRRSLLS--EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEM 3136
Query: 300 EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE------ 353
+VEL++ + +L E + + + +L+ A +LE L A++ LK+LE
Sbjct: 3137 QVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3196
Query: 354 ------------------------------EKLKGQADYEEVKKELNILK-SMEFAPSEG 382
EK K E K+EL LK S+E
Sbjct: 3197 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256
Query: 383 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQV-------RITEAVATA 435
+ + LL E + ++S+ S+ GR ELQV RI E +T
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 436 TEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPE 495
+REL A+L+ QS RP +E L+++ + ++E + +
Sbjct: 3317 DRERELHAQLQSSDGTGQS--RPPL--PSEDLLKELQKQLEEK----HSRIVELLNETEK 3368
Query: 496 GQVDSLLSIISSQRERFRAR-----NQELEAENRLAQHTLQA----LQSELDSLRADNIK 546
++DSL + +++R R QE E + H LQ+ LQ +L+ R K
Sbjct: 3369 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3428
Query: 547 L 547
L
Sbjct: 3429 L 3429
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 54/397 (13%)
Query: 219 RTELFDLKTKYDEETTAKAD-EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQL 277
R E F + Y E+ + +EM+ ++L E RE E +R ++ LQ
Sbjct: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMR--VTYGTEGLQQ 192
Query: 278 ASQIQKAPDVEQAIEVLTRSSLEVELAAKE-----REIAQLVEDVQRLQASLTKLREN-- 330
+ + A ++Q ++T+ + ++ A +E RE +L E Q+LQ +L+ +
Sbjct: 193 LQEFEAA--IKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250
Query: 331 --SASQISQLEQQLSAKNSTL---KQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGT 385
+++ S L AK L +QLEE+ DY++ K++ + S
Sbjct: 251 LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF---------- 300
Query: 386 QDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARL 445
+ ++V +E+++ +++ N + + EL +I E E ++ +
Sbjct: 301 --LQEKIKVYEMEQDKKVENSN---KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTA 355
Query: 446 EQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII 505
++ L +Q + +LE KE + ++ L+ +
Sbjct: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS--------------SEEIKQLMGTV 401
Query: 506 SSQRERFRARNQ-ELEAENRLAQHT---LQALQSELDSLRADNIKLFEKIKFLQSYPGRG 561
++R +Q E + R+ Q T L+ L++ELD + I ++ Q
Sbjct: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHM---- 457
Query: 562 SGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLS 598
+ ++ + R+ + E L +S+ + E Q K ++++
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494
Score = 43.9 bits (102), Expect = 5e-04
Identities = 73/370 (19%), Positives = 150/370 (40%), Gaps = 53/370 (14%)
Query: 30 VLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAF 89
+L Q + E+ R++E E +K + L+ + + + + K + + A
Sbjct: 3344 LLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR-----QQMEKDRQVHRKTLQTEQEAN 3398
Query: 90 LNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT 149
K++ ++ V DL +QL+ K Q+++ ++ E Q+L+ ++E+ K+ E + + +
Sbjct: 3399 TEGQKKMHELQSKVE--DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES 3456
Query: 150 IKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKE-RKLQETQMSTTSKLEEAEHKV 208
+ L + + E T +QK++ + E KL E T E E
Sbjct: 3457 RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIR 3516
Query: 209 QSLQTALEKTR------TELFDLKTKYDEETTAKADEIEMIMTDLER------------- 249
Q LQ K + +E +T DE+ + I+ I+ L++
Sbjct: 3517 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576
Query: 250 ------------ANQRAEVAQREAETLREQLSSANHSLQLASQIQ------KAPDVEQAI 291
Q AE+ ++ E+ N ++L QI+ D
Sbjct: 3577 PSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRF 3636
Query: 292 EVLTRSSLEVELAAKE----REIAQLVEDVQRLQASLTKLRENSASQISQLEQQLS--AK 345
+ +++E +A+++ RE L + ++R +A + KL+ + L Q LS ++
Sbjct: 3637 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN--DSLLQTLSPDSE 3694
Query: 346 NSTLKQLEEK 355
+ TLK++ K
Sbjct: 3695 HVTLKRIYGK 3704
Score = 42.7 bits (99), Expect = 0.001
Identities = 78/408 (19%), Positives = 159/408 (38%), Gaps = 62/408 (15%)
Query: 40 QSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNV---YKRL 96
+S+ + E+ E EDL++Q L + + + + S K E + + Y L
Sbjct: 812 KSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL 871
Query: 97 IDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEK 156
+ V D + Q+L+ K + L+ N+E + T+K +K
Sbjct: 872 LKVKDDLEDSKNKQELEYKSK---------------LKALNEELHLQRINPTTVK-MKSS 915
Query: 157 IREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHKVQSLQT 213
+ + ++T AET LE + ++ D E KL+ T+ + + +L + +++
Sbjct: 916 VFDEDKTFV--AET--LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG 971
Query: 214 ALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANH 273
+ E+ LK + E+ + + E+E+I+ N ++ Q + ++
Sbjct: 972 EISFLNEEVKSLKQE-KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 274 SLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS 333
+ S++ K+ E I V + S E +E + QL+ D + LR S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS 1090
Query: 334 QISQLEQQLSAKNST----------------------LKQLEEKLKGQAD---------- 361
+ +L+++L+ S + Q+ E ++ + D
Sbjct: 1091 ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL 1150
Query: 362 ---YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 406
EE KEL + +E + T D KPL +L+ + +++ E
Sbjct: 1151 IFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198
Score = 40.4 bits (93), Expect = 0.005
Identities = 122/609 (20%), Positives = 226/609 (37%), Gaps = 107/609 (17%)
Query: 11 YWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREF--KKNTPEDLRKQVAPLL 68
Y+ L Q Q TV ++E + K L E +E + P D+ + +L
Sbjct: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546
Query: 69 KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE--- 125
+S+ + F + ++ I V ++D +QL L ++L D+ E
Sbjct: 1547 --------TISEEMFSKDKTF--IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVR 1596
Query: 126 ----NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQA----ETIALEKEQ 177
+Q+ E L + + +++ Q + L+E+I+ + L ++ E + E+E+
Sbjct: 1597 QYQEHQQATELLRQAHMR--QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654
Query: 178 KL--------QNDFAEKERKLQETQMSTTS---------KLEEAEHKVQSLQT------- 213
L Q A +E+ E + S+T ++EE K + L
Sbjct: 1655 VLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPP 1714
Query: 214 --------ALEKTRTELFDLKTKYDEETTAKADEI------------------EMIMTDL 247
AL+K L + + + T A + I +I
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKE 307
A+ ++ V + E + S + S + I V + L++ + A E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
Query: 308 --REIAQLVEDVQ-RLQASLTKLRENSASQISQLEQ----QLSAKNSTLKQLEEKLKGQA 360
E +L+ ++ RLQA++ KL E + SQLE Q + +Q +E +
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894
Query: 361 DYEEVKKELNILK------SMEFAPSEGA--GTQDAAKPLEVLLLEKNRSLQSENAALRI 412
EE+++ L+ ++E + +EG G D E + EK + L
Sbjct: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954
Query: 413 SNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIP 472
+++ L AE Q E+REL++R ++ + G E +L +
Sbjct: 1955 ASNRLQELEAEQQ--------QIQEERELLSRQKEAMKA--------EAGPVEQQLLQET 1998
Query: 473 EPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQA 532
E + + A L + QV +L + Q RF QE E + QA
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDL-QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA 2057
Query: 533 LQSELDSLR 541
L+ +L+ +R
Sbjct: 2058 LEKQLEKMR 2066
Score = 38.9 bits (89), Expect = 0.016
Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 68/488 (13%)
Query: 122 IETENQKLRETLEEYNKEFAEVKNQEVTI-KALKEK------IREYEQTLKNQAETIAL- 173
+E + +L E LE +E E+ + + + LK+K + E ++LK + E ++L
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLR 993
Query: 174 --EKEQKLQNDFAEKERKLQETQMST------TSKLEEAEHKVQSLQTALEKTRTELFDL 225
E E + ++ AE + +TQ+S+ T AE V + + + + +
Sbjct: 994 CRELEIIINHNRAENVQSC-DTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052
Query: 226 KTKYDEETTAKADEIEMIMTD----LERANQRAEVAQREAETLREQLS---SANHSLQLA 278
K ++ T + + E ++ D + + + E + L+++L+ S + L+L
Sbjct: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112
Query: 279 SQIQK-------APDVEQAIEVLTRS------SLEVELAAKEREIAQLVEDVQRLQASLT 325
+ Q+ + V+Q E + SL+ EL + E + ++ + +L+
Sbjct: 1113 MEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTM 1172
Query: 326 KLRENSASQ------ISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAP 379
K +E I +L++ +S + S Q + G+ +K E+N E
Sbjct: 1173 KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNA----EDKE 1228
Query: 380 SEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQR 439
+ G + P + + Q L ++ + LQ R+++ T+
Sbjct: 1229 NSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288
Query: 440 EL------IARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGAL 493
+L + + E + I S + H+ + E T L
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL------------ 1336
Query: 494 PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSEL--DSLRADNIKLFEKI 551
E QV L S+ISS +++ + Q EAE Q LQA+ SL D++ + E
Sbjct: 1337 -EEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
Query: 552 KFLQSYPG 559
YPG
Sbjct: 1396 AQRTMYPG 1403
Score = 38.1 bits (87), Expect = 0.027
Identities = 112/591 (18%), Positives = 231/591 (39%), Gaps = 99/591 (16%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+L+ L+ E AT LA+ ++++E+ ++ L+ K+ L+K ++ +
Sbjct: 2690 ELEALRAESVATKAELASYKEKAEKLQEELL-----VKETNMTSLQKDLSQVRDHLAEAK 2744
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 135
+ LS KE E K + P P+ L + + + I + NQ + ++
Sbjct: 2745 EKLSILEKEDETEVQESKKACMFEPLPIK---LSKSIASQTDGTLKISSSNQTPQILVKN 2801
Query: 136 YNKEF---AEVKNQEVT--IKALKEKIREYEQT---------LKNQAETIALEKE----- 176
+ +E ++EVT I EKI + ++ ++ +ET L++E
Sbjct: 2802 AGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAV 2861
Query: 177 QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQT--------------ALEKTRTEL 222
Q L+ + + +Q + S + E H + QT + T ++
Sbjct: 2862 QLLKEECGTLKAVIQCLRSKEGSSIPELAHS-DAYQTREICSSDSGSDWGQGIYLTHSQG 2920
Query: 223 FDLKTK-YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQI 281
FD+ ++ EE+ + D + L RA E Q + T +HS+Q Q+
Sbjct: 2921 FDIASEGRGEESESATDSFPKKIKGLLRAVHN-EGMQVLSLTESPYSDGEDHSIQ---QV 2976
Query: 282 QKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR------------E 329
+ E+ + T SSL+ + + + V D + S + R E
Sbjct: 2977 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE 3036
Query: 330 NSASQISQLEQQLSAKNST-----LKQLEEKLKGQA-DYEEVKKEL------NILKSMEF 377
+ ++ +L+A +T L LE++++ Q +Y+ + L ++L ++
Sbjct: 3037 ERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQA 3096
Query: 378 APSEGAGT-------QDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITE 430
++ G Q++ KP + LL + QS+ +++ S + R ELQ +++
Sbjct: 3097 LHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSS 3156
Query: 431 AVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPAS 490
E + +A+ + +L Q + RLE +K+ T
Sbjct: 3157 EKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE-----VKDKT----------- 3200
Query: 491 GALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR 541
+V L ++S++++ R LE E + + + EL+ L+
Sbjct: 3201 -----DEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3246
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 84.7 bits (208), Expect = 3e-16
Identities = 113/585 (19%), Positives = 244/585 (41%), Gaps = 89/585 (15%)
Query: 16 DLQQLQRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKS 70
++++L+++L+A + + + E +E S+ I Q RE K ++ +V+ + ++
Sbjct: 743 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 802
Query: 71 FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
+ E+ L ++ EA ++V + + + + +L K ++ + + ++ +KLR
Sbjct: 803 LEKELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLR 853
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
E L + +F E +E + KEK+ + + +K + + + K+ ++ KER
Sbjct: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERD 911
Query: 190 LQETQMSTTSKLEEA--------------------------------EHKVQSLQTALEK 217
++E Q+ T E A E K+ L+ +E
Sbjct: 912 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971
Query: 218 TRTELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANH 273
+ + +LK +Y+ T+ + E I+ +L++ + + A+ E L ++L
Sbjct: 972 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
Query: 274 SLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS 333
A Q A D Q +E +T+ E + ++ + + +LQ L L+EN+
Sbjct: 1032 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK-----QTNAKLQNELDTLKENNLK 1086
Query: 334 QISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLE 393
+ +L K+ L +E + EE +KE+ LK S+
Sbjct: 1087 NVEELN-----KSKELLTVENQ-----KMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136
Query: 394 VLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQ 453
L ++R + + L S L+ + E++ R ++ + A E++ A L++ +SI
Sbjct: 1137 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK---ASLQKSISITS 1193
Query: 454 S-IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERF 512
+ + DAE LEK ++ + G A A + S++ + S + +
Sbjct: 1194 ALLTEKDAE------LEK----LRNEVTVLRGENASAK------SLHSVVQTLESDKVKL 1237
Query: 513 RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFE-KIKFLQS 556
+ + LE + + + L + D+ ++ + E +I FL S
Sbjct: 1238 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1282
Score = 82.0 bits (201), Expect = 2e-15
Identities = 111/589 (18%), Positives = 251/589 (42%), Gaps = 91/589 (15%)
Query: 58 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 117
E LR ++ ++K + ++A+ + +AE + L+++ D + L Q+ ++KV+
Sbjct: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 697
Query: 118 RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 177
L ++ + + + ++ + + +KA +EK+ + + K +E + K+
Sbjct: 698 ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 747
Query: 178 KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK- 236
+ Q + AEK+ K E + + S K S+ L+ +L +L+ E + K
Sbjct: 748 RQQLEAAEKQIKHLEIEKNAESS------KASSITRELQGRELKLTNLQENLSEVSQVKE 801
Query: 237 --ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVL 294
E++++ A++ A QR + +L + S D+E+ E L
Sbjct: 802 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----DLEKLRENL 856
Query: 295 TRSSLEVELAAKEREIAQLVEDVQRLQ---ASLTKLRENSASQISQLEQQLSAKNSTLKQ 351
+ +E + K+ QL++ ++L+ A + K+ +++SQ++++ +L K +++
Sbjct: 857 --ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 914
Query: 352 LEEKL-KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
L+ KL K + ++K + + Q+AAK E E+ + L+ + + L
Sbjct: 915 LQLKLTKANENASFLQKSIE-----DMTVKAEQSQQEAAKKHE----EEKKELERKLSDL 965
Query: 411 RISNSDLSGRCAELQVRITEAVA-TATEQRELIARL---------------EQDLSIIQS 454
+C EL+ R A + T T+ E++ L E++ ++Q
Sbjct: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1025
Query: 455 IQ-------RPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSL----- 501
++ + A AE ++ + + KE T L + A + ++D+L
Sbjct: 1026 LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1085
Query: 502 --LSIISSQRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFEKIKFLQS 556
+ ++ +E NQ++E + + QA +L +L+ +N+KL E++
Sbjct: 1086 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL----- 1140
Query: 557 YPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATL 605
G D+ + E + ++R+ K++ + +KA+L
Sbjct: 1141 ----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASL 1185
Score = 65.1 bits (157), Expect = 2e-10
Identities = 120/584 (20%), Positives = 228/584 (39%), Gaps = 103/584 (17%)
Query: 38 SEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA-------LSKRSKEAEAAFL 90
SE+SR +E+ + +LR+++ + G++D +S ++ E
Sbjct: 461 SEKSRIMELEKDLALRVQEVAELRRRLESNKPA--GDVDMSLSLLQEISSLQEKLEVTRT 518
Query: 91 NVYKRLIDVPDPVPALDLGQQLQLKV--QRLHDIETENQKLRETLEEYNKEFAEVKNQEV 148
+ + + + + A + Q ++K + EN+ L+ LE NKE ++V
Sbjct: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV----- 573
Query: 149 TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 208
IAL K KL+ A ++ ++E ++S + L +
Sbjct: 574 ----------------------IALWK-SKLETAIASHQQAMEELKVSFSKGLGTETAEF 610
Query: 209 QSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETL 264
L+T +EK R E+ +L+ + D E A A E+E + L + + E E +
Sbjct: 611 AELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE---NSLEAI 667
Query: 265 REQLSSA--NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQA 322
R +L A H +++ + K + E ++ LEV L AK E +++++
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-----ELEV-LQAKCNEQTKVIDNF----T 717
Query: 323 SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 382
S K E + L + S S +K+L ++L+ E+ K L I K+ E + +
Sbjct: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASS 774
Query: 383 AGTQDAAKPLEVLLLEKNRS--------LQSENAALRISNSDLSGRCAELQVRITEAVAT 434
+ + L++ L++N S L+ E L+ ++ S +Q + E V
Sbjct: 775 ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 834
Query: 435 ATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALP 494
++ E L DL ++ D E + E+ + IK L
Sbjct: 835 LHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKL------------- 880
Query: 495 EGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFL 554
E + ++ + + N EL RL + ++ LQ +L K E FL
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMNDEL----RLKERDVEELQLKL-------TKANENASFL 929
Query: 555 Q-SYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
Q S ++ ++ + ++EE K+E +RK L
Sbjct: 930 QKSIEDMTVKAEQSQQEAAKKHEE--------EKKELERKLSDL 965
Score = 50.4 bits (119), Expect = 5e-06
Identities = 97/465 (20%), Positives = 186/465 (40%), Gaps = 73/465 (15%)
Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL-----------KNQAETIALEKEQ 177
L ET Y ++ + +ALKEK + EQ L K + +E+E
Sbjct: 336 LTETSSRYARK---ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL 392
Query: 178 KLQNDFAEKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
L D ++ E +M + +E A+ + L LE+ + ++ DL+ + +EE+ K
Sbjct: 393 ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK 452
Query: 237 ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTR 296
D ++ ++++ + + E + A +L S + A DV+ ++ +L
Sbjct: 453 GD------LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESN-KPAGDVDMSLSLLQE 505
Query: 297 SS-----LEVELAAKEREIAQLVE-----------DVQRLQASLTKLRENSASQISQLEQ 340
S LEV +REI L E +++ L + KL + + S S+LE
Sbjct: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
Query: 341 QLSAKNSTLKQLEEKLK-GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
+ + + KL+ A +++ +EL + + S+G GT+ A +EK
Sbjct: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKV------SFSKGLGTETAEFAELKTQIEK 619
Query: 400 NRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS-IQRP 458
R L ++ + N S R A + E A + ++I E L I+S + +
Sbjct: 620 MR-LDYQHEIENLQNQQDSERAAHAK----EMEALRAKLMKVIKEKENSLEAIRSKLDKA 674
Query: 459 DAEGAAE-----HRLEKIPEPIKEATAL-------------FYGPAAPASGALPEGQVDS 500
+ + E ++L++ +KE L F L + +D+
Sbjct: 675 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD--LDA 732
Query: 501 LLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNI 545
L S + + Q+LEA + +H ++ +S +A +I
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSI 775
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 84.7 bits (208), Expect = 3e-16
Identities = 113/585 (19%), Positives = 244/585 (41%), Gaps = 89/585 (15%)
Query: 16 DLQQLQRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKS 70
++++L+++L+A + + + E +E S+ I Q RE K ++ +V+ + ++
Sbjct: 778 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
Query: 71 FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
+ E+ L ++ EA ++V + + + + +L K ++ + + ++ +KLR
Sbjct: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLR 888
Query: 131 ETLEEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
E L + +F E +E + KEK+ + + +K + + + K+ ++ KER
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERD 946
Query: 190 LQETQMSTTSKLEEA--------------------------------EHKVQSLQTALEK 217
++E Q+ T E A E K+ L+ +E
Sbjct: 947 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 1006
Query: 218 TRTELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANH 273
+ + +LK +Y+ T+ + E I+ +L++ + + A+ E L ++L
Sbjct: 1007 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066
Query: 274 SLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSAS 333
A Q A D Q +E +T+ E + ++ + + +LQ L L+EN+
Sbjct: 1067 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK-----QTNAKLQNELDTLKENNLK 1121
Query: 334 QISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLE 393
+ +L K+ L +E + EE +KE+ LK S+
Sbjct: 1122 NVEELN-----KSKELLTVENQ-----KMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1171
Query: 394 VLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQ 453
L ++R + + L S L+ + E++ R ++ + A E++ A L++ +SI
Sbjct: 1172 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK---ASLQKSISITS 1228
Query: 454 S-IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERF 512
+ + DAE LEK ++ + G A A + S++ + S + +
Sbjct: 1229 ALLTEKDAE------LEK----LRNEVTVLRGENASAK------SLHSVVQTLESDKVKL 1272
Query: 513 RARNQELEAENRLAQHTLQALQSELDSLRADNIKLFE-KIKFLQS 556
+ + LE + + + L + D+ ++ + E +I FL S
Sbjct: 1273 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1317
Score = 82.4 bits (202), Expect = 1e-15
Identities = 130/597 (21%), Positives = 242/597 (40%), Gaps = 88/597 (14%)
Query: 35 QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYK 94
Q + E +R + +EQS F+K + L++++ + E + + K+ V +
Sbjct: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517
Query: 95 RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVK--------NQ 146
+ PA D+ L L L +I + +KL T ++ +E +K
Sbjct: 518 LRRRLESNKPAGDVDMSLSL----LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573
Query: 147 EVTIKAL---KEKIREYEQTLKNQAE--------TIALEKEQKLQNDFAEKERKLQETQM 195
+ IKAL EK+ + ++LK++ E IAL K KL+ A ++ ++E ++
Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK-SKLETAIASHQQAMEELKV 632
Query: 196 STTSKLEEAEHKVQSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERAN 251
S + L + L+T +EK R E+ +L+ + D E A A E+E + L +
Sbjct: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692
Query: 252 QRAEVAQREAETLREQLSSA--NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 309
+ E E +R +L A H +++ + K + E ++ LEV L AK E
Sbjct: 693 KEKE---NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-----ELEV-LQAKCNE 743
Query: 310 IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 369
+++++ S K E + L + S S +K+L ++L+ E+ K L
Sbjct: 744 QTKVIDNF----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHL 796
Query: 370 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRS--------LQSENAALRISNSDLSGRC 421
I K+ E + + + + L++ L++N S L+ E L+ ++ S
Sbjct: 797 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 856
Query: 422 AELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATAL 481
+Q + E V ++ E L DL ++ D E + E+ + IK L
Sbjct: 857 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE-NLADMEAKFREKDEREEQLIKAKEKL 915
Query: 482 FYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLR 541
E + ++ + + N EL RL + ++ LQ +L
Sbjct: 916 -------------ENDIAEIMKMSGDNSSQLTKMNDEL----RLKERDVEELQLKL---- 954
Query: 542 ADNIKLFEKIKFLQ-SYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSL 597
K E FLQ S ++ ++ + ++EE K+E +RK L
Sbjct: 955 ---TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE--------EKKELERKLSDL 1000
Score = 82.0 bits (201), Expect = 2e-15
Identities = 111/589 (18%), Positives = 251/589 (42%), Gaps = 91/589 (15%)
Query: 58 EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 117
E LR ++ ++K + ++A+ + +AE + L+++ D + L Q+ ++KV+
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 732
Query: 118 RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 177
L ++ + + + ++ + + +KA +EK+ + + K +E + K+
Sbjct: 733 ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 782
Query: 178 KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK- 236
+ Q + AEK+ K E + + S K S+ L+ +L +L+ E + K
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESS------KASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 237 --ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVL 294
E++++ A++ A QR + +L + S D+E+ E L
Sbjct: 837 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----DLEKLRENL 891
Query: 295 TRSSLEVELAAKEREIAQLVEDVQRLQ---ASLTKLRENSASQISQLEQQLSAKNSTLKQ 351
+ +E + K+ QL++ ++L+ A + K+ +++SQ++++ +L K +++
Sbjct: 892 --ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 352 LEEKL-KGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410
L+ KL K + ++K + + Q+AAK E E+ + L+ + + L
Sbjct: 950 LQLKLTKANENASFLQKSIE-----DMTVKAEQSQQEAAKKHE----EEKKELERKLSDL 1000
Query: 411 RISNSDLSGRCAELQVRITEAVA-TATEQRELIARL---------------EQDLSIIQS 454
+C EL+ R A + T T+ E++ L E++ ++Q
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060
Query: 455 IQ-------RPDAEGAAEHRLEKIPEPIKEAT-ALFYGPAAPASGALPEGQVDSL----- 501
++ + A AE ++ + + KE T L + A + ++D+L
Sbjct: 1061 LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120
Query: 502 --LSIISSQRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFEKIKFLQS 556
+ ++ +E NQ++E + + QA +L +L+ +N+KL E++
Sbjct: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL----- 1175
Query: 557 YPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATL 605
G D+ + E + ++R+ K++ + +KA+L
Sbjct: 1176 ----GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASL 1220
Score = 63.2 bits (152), Expect = 8e-10
Identities = 100/487 (20%), Positives = 200/487 (41%), Gaps = 59/487 (12%)
Query: 115 KVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL---KNQAETI 171
KV+ L+ +E E +K+ + +E + E K +I+E EQ+L K +A+ +
Sbjct: 424 KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKL 483
Query: 172 ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTR-TELFDLKTKYD 230
E E +EK R + E + +++E V L+ LE + D+
Sbjct: 484 QRELEDTRVATVSEKSR-IMELEKDLALRVQE----VAELRRRLESNKPAGDVDMSLSLL 538
Query: 231 EETTAKADEIEMIMTDLERA--------NQRAEVAQREAE---TLREQLSSANHSLQLAS 279
+E ++ +++E+ TD +R R E Q+E + T E+LS N SL+ S
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK--S 596
Query: 280 QIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLE 339
+++ A + L +S LE +A+ + + ++ L+ S +K ++ ++L+
Sbjct: 597 KLEHANKENSDVIALWKSKLETAIASHQ-------QAMEELKVSFSKGLGTETAEFAELK 649
Query: 340 QQLSAKNSTLKQLEEKLKGQADYEEV--KKELNILKSMEFAPSEGAGTQDAAKPLEVLLL 397
Q+ + E L+ Q D E KE+ L++ + A ++
Sbjct: 650 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA 709
Query: 398 EKNRSLQSENAALRISNSDLSGRCAE-LQVRITEAVATATEQRELIARLEQDLSIIQSIQ 456
E ++ E+ ++ +++ + E LQ + E + E+ L + +++
Sbjct: 710 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 769
Query: 457 RPDAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSL--------LS 503
+ +EG +E +LE + IK ++ AS E Q L LS
Sbjct: 770 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
Query: 504 IISS-----------QRERFRARNQELEAENRLAQHTLQAL---QSELDSLRADNIKLFE 549
+S +E+F ++E + R Q T+ L + + + L +D KL E
Sbjct: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 550 KIKFLQS 556
+ +++
Sbjct: 890 NLADMEA 896
Score = 48.9 bits (115), Expect = 2e-05
Identities = 105/493 (21%), Positives = 192/493 (38%), Gaps = 94/493 (19%)
Query: 129 LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL-----------KNQAETIALEKEQ 177
L ET Y ++ + +ALKEK + EQ L K + +E+E
Sbjct: 336 LTETSSRYARK---ISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL 392
Query: 178 KLQNDFAEKERKLQETQMSTT-SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
L D ++ E +M + +E A+ + L LE+ + ++ DL+ + +EE+ K
Sbjct: 393 ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK 452
Query: 237 AD----------EIEMIMTDLERANQRAEVAQREAE-----TLREQLSSANHSLQLASQI 281
D I+ + L +A+ QRE E T+ E+ LA ++
Sbjct: 453 GDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRV 512
Query: 282 QK-------------APDVEQAIEVLTRSS-----LEVELAAKEREIAQLVE-------- 315
Q+ A DV+ ++ +L S LEV +REI L E
Sbjct: 513 QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREET 572
Query: 316 ---DVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK-GQADYEEVKKELNI 371
+++ L + KL + + S S+LE + + + KL+ A +++ +EL +
Sbjct: 573 HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV 632
Query: 372 LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEA 431
+ S+G GT+ A +EK R L ++ + N S R A + E
Sbjct: 633 ------SFSKGLGTETAEFAELKTQIEKMR-LDYQHEIENLQNQQDSERAAHAK----EM 681
Query: 432 VATATEQRELIARLEQDLSIIQS-IQRPDAEGAAE-----HRLEKIPEPIKEATAL---- 481
A + ++I E L I+S + + + + E ++L++ +KE L
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC 741
Query: 482 ---------FYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQA 532
F L + +D+L S + + Q+LEA + +H
Sbjct: 742 NEQTKVIDNFTSQLKATEEKLLD--LDALRKASSEGKSEMKKLRQQLEAAEKQIKHL--E 797
Query: 533 LQSELDSLRADNI 545
++ +S +A +I
Sbjct: 798 IEKNAESSKASSI 810
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 82.8 bits (203), Expect = 1e-15
Identities = 98/451 (21%), Positives = 196/451 (43%), Gaps = 45/451 (9%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
++ +L+ + DA L +E+ ++ + L +S NT E + +K Q E
Sbjct: 777 EMDKLKEQYDAELQALRESVEEATKNVEVLASRS-----NTSEQDQAGTEMRVKLLQEEN 831
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 135
+ L RS+E E + +++ D+ G + + K + L E E ++L E L
Sbjct: 832 EKLQGRSEELERRVAQLQRQIEDLK--------GDEAKAK-ETLKKYEGEIRQLEEALVH 882
Query: 136 YNKEFAEVKNQ----EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 191
KE E + E ++A + + + Q K +E + E EQK E+ R+L+
Sbjct: 883 ARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQK------EQLRRLK 936
Query: 192 ETQMSTTSKLEEAEHKVQS-LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
+ L + K+Q + +E +RT +L+ + DE E+ + L+
Sbjct: 937 NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK 996
Query: 251 NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKE--- 307
AE ++ A +++++ L+ + Q ++ + T LE EL AK
Sbjct: 997 TLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLK 1056
Query: 308 ----REIAQLVEDVQRLQASLTKLRENS----------ASQISQLEQQLSAKNSTLKQLE 353
R + Q+ + V +L+ L + R NS Q+ QL +L + + + LE
Sbjct: 1057 DDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Query: 354 -EKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRI 412
+K+ + +++K + L+ + EG Q A+ E L ++ S + + A L++
Sbjct: 1117 CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAE--LEDRLESEERDRANLQL 1174
Query: 413 SNSDLSGRCAELQVRITEAVATATEQRELIA 443
SN L + EL +++ + + T+Q++ ++
Sbjct: 1175 SNRRLERKVKELVMQVDDEHLSLTDQKDQLS 1205
Score = 72.4 bits (176), Expect = 1e-12
Identities = 103/470 (21%), Positives = 203/470 (43%), Gaps = 43/470 (9%)
Query: 103 VPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQ 162
+ +L +QLQL+V+ +I+ E +++R LEE + E + T L++++ E E
Sbjct: 621 IEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST---LQQRLEESEG 677
Query: 163 TLKNQAE---TIALEKEQ------KLQNDFAEKERKLQETQMSTTSK----LEEAEHKVQ 209
L+ E + +E+EQ LQ+ +E +L + S + +EE Q
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ 737
Query: 210 SLQTALEKTRTELFDLKTKYDEETTA-KADEIEMIMTDLERANQRAEVAQREAETLREQL 268
LQ L + E DL K + E TA K E + + + ++ E E + LRE +
Sbjct: 738 DLQDLL-IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESV 796
Query: 269 SSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQ-LVEDVQRLQASLTKL 327
A ++++ + + +QA + + V+L +E E Q E+++R A L +
Sbjct: 797 EEATKNVEVLASRSNTSEQDQA-----GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 328 RENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQD 387
E+ ++ ++ L ++QLEE L +E K+ ++ +++E G
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR--KEEKEAVSARRALENELEAAQGNLS 909
Query: 388 AAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQ 447
+ L EK + + LR +++ L I + Q+E+ +E
Sbjct: 910 QTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL------QKEMADIVEA 963
Query: 448 DLSIIQSIQRPDAEGAAEHR--LEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII 505
+ +Q E ++R L ++ +KE T A S D + +
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTL-----EAEKSRLTAMKMQDEMRLME 1018
Query: 506 SSQRERFRARNQELEAENRLAQHTLQALQSELDS---LRADNIKLFEKIK 552
R+ RA+++ L + +L + TL+ L+ EL++ L+ D +L ++++
Sbjct: 1019 EELRDYQRAQDEAL-TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQME 1067
Score = 68.9 bits (167), Expect = 1e-11
Identities = 83/385 (21%), Positives = 176/385 (45%), Gaps = 58/385 (15%)
Query: 20 LQRELDATATVLANRQDESEQSRKRLIEQSREFK-----KNTPEDLRKQVAPLLKSFQGE 74
L+ EL+A L+ E +Q ++L E+S + + KN E+ R + ++ Q E
Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
Query: 75 IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQL-QLKVQRLHDIETENQKLRE-T 132
+ + + S+ + L+L QL + K + ++ ++L+E T
Sbjct: 957 MADIVEASRTS-------------------TLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 133 LEEYNKEFAEVKNQEVTIKALKEKIREY--------------EQTLKNQAETIALEKEQK 178
LE +K Q+ ++ ++E++R+Y EQTLK+ LE +
Sbjct: 998 LEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE--YELEAKSH 1054
Query: 179 LQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKAD 238
L++D + +++++ +LEE + L + ++R ++ L+ + +E A+ D
Sbjct: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Query: 239 EIEMIMTDLERANQ--RAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTR 296
+E LER N+ ++ + E + S +Q+ ++I + D ++ E R
Sbjct: 1115 -LECDKISLERQNKDLKSRIIHLEGSY---RSSKEGLVVQMEARIAELEDRLES-EERDR 1169
Query: 297 SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA-------SQISQLEQQLSAKNSTL 349
++L++ ER++ +LV V SLT ++ + Q+ + E+++ S+
Sbjct: 1170 ANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSK 1229
Query: 350 KQLEEKLKGQADY-EEVKKELNILK 373
K+L+ +L+ Q D E ++ +LN +K
Sbjct: 1230 KKLQRELEEQMDMNEHLQGQLNSMK 1254
Score = 65.1 bits (157), Expect = 2e-10
Identities = 130/651 (19%), Positives = 261/651 (40%), Gaps = 110/651 (16%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSR---------------------KRLIEQSREFKK 54
++ +LQR+L N ++E E+ R +RL E E +K
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681
Query: 55 NTPEDL-----RKQVAPLLKSFQGEIDAL------SKRSKEAEAAFLNVYKRLIDVPDPV 103
N E R+Q ++ Q ++ + +KRS++ E L + L+ +
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGAL--IEELLQAKQDL 739
Query: 104 PALDLGQQLQLKVQRLHDIETENQK--LRETLEEYNKEFAEVKNQ-EVTIKALKEKIREY 160
L + ++ Q + R + E K L+E + +++E ++K Q + ++AL+E + E
Sbjct: 740 QDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEA 799
Query: 161 EQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRT 220
+ ++ A ++ + + + + LQE + EE E +V LQ +E +
Sbjct: 800 TKNVEVLASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKG 857
Query: 221 ELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQ 280
+ + K E EI + L A + + A L +L +A +L +Q
Sbjct: 858 D----EAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913
Query: 281 IQ-----KAPDVEQAIEVLTRSSLEVE---------LAAKEREIAQLVE----DVQRLQA 322
Q K + + E L R E+E + ++E+A +VE LQ
Sbjct: 914 EQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQN 973
Query: 323 SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEG 382
L + +E + +++++++QL K TL+ + +L +E++ L+ + A
Sbjct: 974 QLDEYKEKNRRELAEMQRQL--KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA---- 1027
Query: 383 AGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQR--- 439
QD A LL + + L+ E A D S +++ ++++ E+R
Sbjct: 1028 ---QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNS 1084
Query: 440 ----ELIARLEQDLSIIQS------IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPA 489
E I+R + + +++ R D E + LE+ + +K G +
Sbjct: 1085 DLLSERISRSREQMEQLRNELLQERAARQDLE-CDKISLERQNKDLKSRIIHLEGSYRSS 1143
Query: 490 SGALPEGQVDSLLSIISSQRERFRARNQE---LEAENRLAQHTLQALQSELD----SLRA 542
EG V + + I+ +R + ++ L+ NR + ++ L ++D SL
Sbjct: 1144 K----EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Query: 543 DNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRK 593
+L ++K ++ R + EE +D S SK++ QR+
Sbjct: 1200 QKDQLSLRLKAMK--------------RQVEEAEEEIDRLES-SKKKLQRE 1235
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 81.6 bits (200), Expect = 2e-15
Identities = 86/353 (24%), Positives = 148/353 (41%), Gaps = 51/353 (14%)
Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
+E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q
Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 273 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 332
L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+
Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 333 S------------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV--- 365
S Q +L+++LS ST+ +L+E++ EE+
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 366 --KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAE 423
+ LN+ + + E G +A + L E R + E LR R E
Sbjct: 309 LTDRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVRE 364
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 473
Q R+ A T + ++ I + Q + +Q + R E + E + + PE
Sbjct: 365 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
Score = 77.0 bits (188), Expect = 5e-14
Identities = 88/410 (21%), Positives = 174/410 (42%), Gaps = 41/410 (10%)
Query: 66 PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
P+L S G + L SKE E V D+ + + L L + + +LK H I
Sbjct: 65 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 119
Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
+ E K++E + + E + + KE+ E + E L+KE
Sbjct: 120 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 179
Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
+ LQ + + ++ E E E K S Q LE+ L D
Sbjct: 180 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 239
Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
+ + ++++ E + +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A
Sbjct: 240 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
Query: 285 PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 344
E+ +E+LT +L +E K RE+ + V D++ + +L+EN+ +L +QL
Sbjct: 300 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
Query: 345 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
+ +++ +++++ ADY++ +KK + ++ E Q+A+ +E+
Sbjct: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 410
Query: 400 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 448
+ E +I ++ +++ + + VA A L+ D
Sbjct: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 460
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/303 (19%), Positives = 124/303 (40%), Gaps = 30/303 (9%)
Query: 26 ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
A A +A E + R ++Q E K ++L + L + G A S
Sbjct: 167 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 226
Query: 80 KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
K+ +E A + R+ D+ + + L + ++ K Q L + + ++L+E L +
Sbjct: 227 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 286
Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
E+K Q E ++ L ++ E+ ++ ET+ + ND E +
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 344
Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
+ET++ +L+ A +V+ Q +E + + D ++T K ++ + D+ R
Sbjct: 345 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNR- 398
Query: 251 NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREI 310
E+ ++ ++ Q + + + +AIE+ R ++E+A R +
Sbjct: 399 ----ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 451
Query: 311 AQL 313
+ L
Sbjct: 452 SLL 454
Score = 37.4 bits (85), Expect = 0.046
Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)
Query: 94 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
+++ P P L Q + + ++ + T Q+ EY+ E K V ++A
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795
Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855
Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
+++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 81.6 bits (200), Expect = 2e-15
Identities = 86/353 (24%), Positives = 148/353 (41%), Gaps = 51/353 (14%)
Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
+E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q
Sbjct: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256
Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++
Sbjct: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 316
Query: 273 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 332
L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+
Sbjct: 317 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 362
Query: 333 S------------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV--- 365
S Q +L+++LS ST+ +L+E++ EE+
Sbjct: 363 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 422
Query: 366 --KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAE 423
+ LN+ + + E G +A + L E R + E LR R E
Sbjct: 423 LTDRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVRE 478
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 473
Q R+ A T + ++ I + Q + +Q + R E + E + + PE
Sbjct: 479 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 531
Score = 77.0 bits (188), Expect = 5e-14
Identities = 88/410 (21%), Positives = 174/410 (42%), Gaps = 41/410 (10%)
Query: 66 PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
P+L S G + L SKE E V D+ + + L L + + +LK H I
Sbjct: 179 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 233
Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
+ E K++E + + E + + KE+ E + E L+KE
Sbjct: 234 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 293
Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
+ LQ + + ++ E E E K S Q LE+ L D
Sbjct: 294 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 353
Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
+ + ++++ E + +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A
Sbjct: 354 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 413
Query: 285 PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 344
E+ +E+LT +L +E K RE+ + V D++ + +L+EN+ +L +QL
Sbjct: 414 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 471
Query: 345 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
+ +++ +++++ ADY++ +KK + ++ E Q+A+ +E+
Sbjct: 472 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 524
Query: 400 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 448
+ E +I ++ +++ + + VA A L+ D
Sbjct: 525 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 574
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/303 (19%), Positives = 124/303 (40%), Gaps = 30/303 (9%)
Query: 26 ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
A A +A E + R ++Q E K ++L + L + G A S
Sbjct: 281 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 340
Query: 80 KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
K+ +E A + R+ D+ + + L + ++ K Q L + + ++L+E L +
Sbjct: 341 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 400
Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
E+K Q E ++ L ++ E+ ++ ET+ + ND E +
Sbjct: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 458
Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
+ET++ +L+ A +V+ Q +E + + D ++T K ++ + D+ R
Sbjct: 459 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNR- 512
Query: 251 NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREI 310
E+ ++ ++ Q + + + +AIE+ R ++E+A R +
Sbjct: 513 ----ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 565
Query: 311 AQL 313
+ L
Sbjct: 566 SLL 568
Score = 37.4 bits (85), Expect = 0.046
Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)
Query: 94 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
+++ P P L Q + + ++ + T Q+ EY+ E K V ++A
Sbjct: 855 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 909
Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+
Sbjct: 910 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 969
Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
+++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR
Sbjct: 970 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 81.6 bits (200), Expect = 2e-15
Identities = 86/353 (24%), Positives = 148/353 (41%), Gaps = 51/353 (14%)
Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
+E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q
Sbjct: 83 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 273 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 332
L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+
Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 333 S------------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV--- 365
S Q +L+++LS ST+ +L+E++ EE+
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 366 --KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAE 423
+ LN+ + + E G +A + L E R + E LR R E
Sbjct: 309 LTDRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVRE 364
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 473
Q R+ A T + ++ I + Q + +Q + R E + E + + PE
Sbjct: 365 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 417
Score = 77.0 bits (188), Expect = 5e-14
Identities = 88/410 (21%), Positives = 174/410 (42%), Gaps = 41/410 (10%)
Query: 66 PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
P+L S G + L SKE E V D+ + + L L + + +LK H I
Sbjct: 65 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 119
Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
+ E K++E + + E + + KE+ E + E L+KE
Sbjct: 120 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 179
Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
+ LQ + + ++ E E E K S Q LE+ L D
Sbjct: 180 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 239
Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
+ + ++++ E + +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A
Sbjct: 240 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 299
Query: 285 PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 344
E+ +E+LT +L +E K RE+ + V D++ + +L+EN+ +L +QL
Sbjct: 300 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 357
Query: 345 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
+ +++ +++++ ADY++ +KK + ++ E Q+A+ +E+
Sbjct: 358 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 410
Query: 400 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 448
+ E +I ++ +++ + + VA A L+ D
Sbjct: 411 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 460
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/303 (19%), Positives = 124/303 (40%), Gaps = 30/303 (9%)
Query: 26 ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
A A +A E + R ++Q E K ++L + L + G A S
Sbjct: 167 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 226
Query: 80 KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
K+ +E A + R+ D+ + + L + ++ K Q L + + ++L+E L +
Sbjct: 227 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 286
Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
E+K Q E ++ L ++ E+ ++ ET+ + ND E +
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 344
Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
+ET++ +L+ A +V+ Q +E + + D ++T K ++ + D+ R
Sbjct: 345 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNR- 398
Query: 251 NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREI 310
E+ ++ ++ Q + + + +AIE+ R ++E+A R +
Sbjct: 399 ----ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 451
Query: 311 AQL 313
+ L
Sbjct: 452 SLL 454
Score = 37.4 bits (85), Expect = 0.046
Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)
Query: 94 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
+++ P P L Q + + ++ + T Q+ EY+ E K V ++A
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795
Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855
Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
+++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 81.6 bits (200), Expect = 2e-15
Identities = 86/353 (24%), Positives = 148/353 (41%), Gaps = 51/353 (14%)
Query: 154 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 212
+E +R + L+ + ET+ L++ E K + EK + E SK++E + +Q
Sbjct: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
Query: 213 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 272
K E + K +Y EE AD IEM D E A +RAE Q+E E L+E++
Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 336
Query: 273 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 332
L++ E+ + S + AA ++ QL E RL+ +L ++R+ S+
Sbjct: 337 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 382
Query: 333 S------------------------QISQLEQQLSAKNSTLKQLEEKLKGQADYEEV--- 365
S Q +L+++LS ST+ +L+E++ EE+
Sbjct: 383 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 442
Query: 366 --KKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAE 423
+ LN+ + + E G +A + L E R + E LR R E
Sbjct: 443 LTDRNLNLEEKVR-ELRETVGDLEAMNEMNDELQENARETELE---LREQLDMAGARVRE 498
Query: 424 LQVRITEAVATATEQRELIARLEQDLSIIQSIQRP---DAEGAAEHRLEKIPE 473
Q R+ A T + ++ I + Q + +Q + R E + E + + PE
Sbjct: 499 AQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPE 551
Score = 77.0 bits (188), Expect = 5e-14
Identities = 88/410 (21%), Positives = 174/410 (42%), Gaps = 41/410 (10%)
Query: 66 PLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQ---QLQLKVQRLHDI 122
P+L S G + L SKE E V D+ + + L L + + +LK H I
Sbjct: 199 PVLTS-PGAVPPLPSPSKEEEGLRAQVR----DLEEKLETLRLKRAEDKAKLKELEKHKI 253
Query: 123 ETEN-----QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE- 176
+ E K++E + + E + + KE+ E + E L+KE
Sbjct: 254 QLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEM 313
Query: 177 -----QKLQNDFAEKERKLQETQMSTTSKLEEAEHK-----VQSLQ-TALEKTRTELFDL 225
+ LQ + + ++ E E E K S Q LE+ L D
Sbjct: 314 AEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDA 373
Query: 226 KTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKA 284
+ + ++++ E + +E+ NQ EV +++ E L+E+LS A ++ +L Q+ A
Sbjct: 374 LVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAA 433
Query: 285 PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 344
E+ +E+LT +L +E K RE+ + V D++ + +L+EN+ +L +QL
Sbjct: 434 LGAEEMVEMLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDM 491
Query: 345 KNSTLKQLEEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 399
+ +++ +++++ ADY++ +KK + ++ E Q+A+ +E+
Sbjct: 492 AGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS-------VER 544
Query: 400 NRSLQSENAALRISNSDLSGRCAELQVRITE-AVATATEQRELIARLEQD 448
+ E +I ++ +++ + + VA A L+ D
Sbjct: 545 QQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPD 594
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/303 (19%), Positives = 124/303 (40%), Gaps = 30/303 (9%)
Query: 26 ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQ--GEIDALS---- 79
A A +A E + R ++Q E K ++L + L + G A S
Sbjct: 301 ADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQL 360
Query: 80 KRSKEAEAAFLNVYKRLIDVP--DPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 137
K+ +E A + R+ D+ + + L + ++ K Q L + + ++L+E L +
Sbjct: 361 KQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAE 420
Query: 138 KEFAEVKNQ-------EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKL 190
E+K Q E ++ L ++ E+ ++ ET+ + ND E +
Sbjct: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND--ELQENA 478
Query: 191 QETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 250
+ET++ +L+ A +V+ Q +E + + D ++T K ++ + D+ R
Sbjct: 479 RETELELREQLDMAGARVREAQKRVEAAQETVADY-----QQTIKKYRQLTAHLQDVNR- 532
Query: 251 NQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREI 310
E+ ++ ++ Q + + + +AIE+ R ++E+A R +
Sbjct: 533 ----ELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELR---QMEVAQANRHM 585
Query: 311 AQL 313
+ L
Sbjct: 586 SLL 588
Score = 37.4 bits (85), Expect = 0.046
Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)
Query: 94 KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 152
+++ P P L Q + + ++ + T Q+ EY+ E K V ++A
Sbjct: 875 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 929
Query: 153 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 206
L+ +I + E LK ET+ E ++ L+ + +E +L + S ++A+
Sbjct: 930 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 989
Query: 207 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 265
+++ +QT LE+T+ L + +++E A +I+ + + QR ++R E LR
Sbjct: 990 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 80.5 bits (197), Expect = 5e-15
Identities = 125/569 (21%), Positives = 243/569 (42%), Gaps = 71/569 (12%)
Query: 17 LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAP-----LLKSF 71
L+ ++++ A T L+ DE E++ ++++ + EFK+ K+++ L K
Sbjct: 439 LEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL 498
Query: 72 QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 131
G + ++K +EA L + K+ ++ G+Q ++K D++ L
Sbjct: 499 SGRLQLVNKLRQEALDLELQMEKQKQEIA--------GKQKEIK-----DLQIAIDSLDS 545
Query: 132 TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 191
+++ A+ +E + + ++ ++ E L IA E E+ + E +L
Sbjct: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE-----IKDLEEQLT 600
Query: 192 ETQMSTTSKLE-EAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM---TDL 247
E Q++ L+ + E + LQ L + + T+ E DE E ++ T++
Sbjct: 601 EGQIAANEALKKDLEGVISGLQEYLGTIKGQA----TQAQNECRKLRDEKETLLQRLTEV 656
Query: 248 ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKE 307
E+ + E+ +AE +R++L+ +LQ ++ + Q + LE L ++
Sbjct: 657 EQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRD 716
Query: 308 REIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE---- 363
E QL E+++++ LT+L E SA Q +++ + KN+ K + K Q + E
Sbjct: 717 AEANQLKEELEKV-TRLTQL-EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAK 774
Query: 364 --EVKKELNILKSM--EFAPSEGAGTQDAAKPLEVLLL--EKNRSLQSENAALRI-SNSD 416
++ + N+LK +F +P EV E R L+ + I S SD
Sbjct: 775 LKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSD 834
Query: 417 LSGRC-AELQVRITEAVATATEQR-----------ELIARLEQDLSIIQSIQRPDAEGAA 464
+ G+ A+LQ + +E +A + +R E +A ++ L+ Q R E A
Sbjct: 835 VLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERAL 894
Query: 465 EHRLE--------KIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARN 516
E R+ +I + E + Y S +G D L ++ER A+
Sbjct: 895 EARMNFDKRQHEARIQQMENE---IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQL 951
Query: 517 QELEAENRL----AQHTLQALQSELDSLR 541
+ELE + +L +Q + L EL L+
Sbjct: 952 RELEKKKKLEDAKSQEQVFGLDKELKKLK 980
Score = 72.4 bits (176), Expect = 1e-12
Identities = 127/547 (23%), Positives = 235/547 (42%), Gaps = 79/547 (14%)
Query: 12 WKRFDLQQLQR-ELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS 70
++RF L++++R E D ++ + +S+Q+R +E+ + K L KS
Sbjct: 264 FERFSLEEVERLERDLEKKMIETEELKSKQTR--FLEEIKNQDK------------LNKS 309
Query: 71 FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 130
+ E L K+S E + LN L+ +L Q+ +++E E +
Sbjct: 310 LKEEA-MLQKQSCEELKSDLNTKNELLKQKTI--------ELTRACQKQYELEQELAFYK 360
Query: 131 -----ETLEEYNKEFAEV-----KNQEVTIKALKEKIREYEQTLKNQAETIALEK---EQ 177
E L Y E+AE+ ++ + K + E + + A+ + ++K ++
Sbjct: 361 IDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDE 420
Query: 178 KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKA 237
+L+ND T + T +LE+ E K+ + QT L +EL D K +++
Sbjct: 421 QLRNDHMNLRG---HTPLDT--QLEDKEKKISAAQTRL----SELHDEIEKAEQQILRAT 471
Query: 238 DEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQI-QKAPDVEQAIEVLTR 296
+E + LE A Q ++++ + L +QLS LQL +++ Q+A D+E +E
Sbjct: 472 EEFKQ----LEEAIQLKKISEAGKDLLYKQLSGR---LQLVNKLRQEALDLELQME---- 520
Query: 297 SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL 356
+ E+A K++EI L + L + K + +Q S EQQL N +QLE +L
Sbjct: 521 -KQKQEIAGKQKEIKDLQIAIDSLDSKDPK-HSHMKAQKSGKEQQLDIMNKQYQQLESRL 578
Query: 357 KGQADYEEVKKELNILKSMEFAPSEG--AGTQDAAKPLEVLLLEKNRSLQSENAALRISN 414
+ KE +K +E +EG A + K LE ++ LQ ++
Sbjct: 579 --DEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVI----SGLQEYLGTIKGQA 632
Query: 415 SDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEP 474
+ C +L+ + TE + +LE +++++ AE LE +
Sbjct: 633 TQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAE------LESALQE 686
Query: 475 IKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQ 534
E A S E ++++ L++ ++ + + +ELE RL Q ALQ
Sbjct: 687 QHEVNASLQQTQGDLSAY--EAELEARLNLRDAEANQLK---EELEKVTRLTQLEQSALQ 741
Query: 535 SELDSLR 541
+EL+ R
Sbjct: 742 AELEKER 748
Score = 69.3 bits (168), Expect = 1e-11
Identities = 93/424 (21%), Positives = 190/424 (44%), Gaps = 64/424 (15%)
Query: 21 QRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK---SFQGEIDA 77
+++L T VLA ++ S+ + L + +K L++++ L + S +I A
Sbjct: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK-----LQQELDQLNRDKLSLHNDISA 1854
Query: 78 LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIE-TENQKLRETLEEY 136
+ ++ +E A ++ + L +V D L+L +Q L + D+ +E +L++ + E+
Sbjct: 1855 MQQQLQEKREAVNSLQEELANVQDH---LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911
Query: 137 NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 196
F + + +E T + ++ Q LQN+ E + KL + +M
Sbjct: 1912 ANRFEDCQKEEETKQ----------------------QQLQVLQNEIEENKLKLVQQEM- 1948
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 256
+ + + +S ++ LE ++ L + + + ++E T + +++ +++ + A +R
Sbjct: 1949 ---MFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005
Query: 257 AQRE---AETLREQLSSANHSLQLASQ-----------IQKAPDVEQAIEVLTRSSLEVE 302
Q E E+L + LS L Q +QK D +A L R+ E
Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTE 2065
Query: 303 LAAKEREIAQLVE--DVQRLQAS---LTKLRENSASQISQLEQQLSAKNS---TLKQLEE 354
E+++A L E +QR Q L + +ENS Q +L A+++ + ++E
Sbjct: 2066 RKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE 2125
Query: 355 KLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR-SLQSENAALRIS 413
+ Q +Y E+KK++ K +E E DA + L+ + ++ R SL++ N L
Sbjct: 2126 LNQMQYEYTELKKQMANQKDLERRQME---ISDAMRTLKSEVKDEIRTSLKNLNQFLPEL 2182
Query: 414 NSDL 417
+DL
Sbjct: 2183 PADL 2186
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/550 (20%), Positives = 219/550 (39%), Gaps = 63/550 (11%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
+LQ+LQ++++ +A R ++ + E + K+ E L+ QV S Q E+
Sbjct: 1546 ELQKLQKDIE-----MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVT----SQQQEM 1596
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVP-DPVPALDLGQ-QLQLKVQRLHDIETENQKLRETL 133
L ++ + + ++ D AL LG+ ++ K + ++++ ++L
Sbjct: 1597 AVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQK 1656
Query: 134 EEYNKEFAEVKNQEVTIKALKEKIRE-----------YEQTLKNQAETIALEKEQKLQND 182
E N + +E K Q IK EK E ++ LKN + + LE + LQ
Sbjct: 1657 GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHE-LQGL 1715
Query: 183 FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 242
+ ++++ E + + + LEE + ++++LQ ++ + E+ K + + EIE
Sbjct: 1716 KLQHDQRVSELEKTQVAVLEE-KLELENLQQISQQQKGEIEWQKQLLERDKR----EIER 1770
Query: 243 IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE 302
+ + E +E E L+E+ L ++ A + +E LE+
Sbjct: 1771 MTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN 1830
Query: 303 LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADY 362
+ ++E+ QL D L + IS ++QQL K + L+E+L D+
Sbjct: 1831 VRKLQQELDQLNRDKLSLH-----------NDISAMQQQLQEKREAVNSLQEELANVQDH 1879
Query: 363 EEVKKE--LNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGR 420
+ K+ L+ K + SE Q + + +++ L++
Sbjct: 1880 LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQV-------- 1931
Query: 421 CAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAE--HRLEKIPEPIKEA 478
LQ I E +Q + RL+++ +S E H+LEK K
Sbjct: 1932 ---LQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSK 1988
Query: 479 TALFYGPAAPASGAL-----PEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQAL 533
A + E +SL +S + + R Q+L ++ L AL
Sbjct: 1989 LDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSG----ELLAL 2044
Query: 534 QSELDSLRAD 543
Q E DS+RAD
Sbjct: 2045 QKEADSMRAD 2054
Score = 63.5 bits (153), Expect = 6e-10
Identities = 72/360 (20%), Positives = 166/360 (46%), Gaps = 43/360 (11%)
Query: 115 KVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE 174
K Q ++E + + + L+E EV+ T++ +++ + +++ + +E
Sbjct: 1349 KRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408
Query: 175 KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE--- 231
K K D ++ +++T + S+L EA+ + ++ L T+ + + K+ +
Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468
Query: 232 ---ETTAKADEIEM----IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKA 284
+T + A+E+E +L +A+Q+ Q +A+ L + +I++
Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQH------------KIKQE 1516
Query: 285 PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ--- 341
+++ +++ + + +K++E +L E++Q+LQ + N + L++
Sbjct: 1517 EILKEINKIVAAKDSDFQCLSKKKE--KLTEELQKLQKDIEMAERNEDHHLQVLKESEVL 1574
Query: 342 LSAKNSTLKQLEEKLKGQADYEEV--------KKELNILK-SMEFAPSEGAGTQDAAKPL 392
L AK + L++L+ ++ Q V K+EL++L+ SM A A Q+A +
Sbjct: 1575 LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAK---ADLQEALRLG 1631
Query: 393 EVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSII 452
E + EK ++ + L +LS + EL V+I+E T ++ I + E++L ++
Sbjct: 1632 ETEVTEKCNHIREVKSLL----EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVV 1687
Score = 60.8 bits (146), Expect = 4e-09
Identities = 117/581 (20%), Positives = 229/581 (39%), Gaps = 67/581 (11%)
Query: 16 DLQQLQRELDATATVLANRQ--DESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
+++ L EL+ ++ + DE E K L+++ E + + LL +
Sbjct: 1397 NVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR---------EADRLLAEAES 1447
Query: 74 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALD------------LGQQLQLKVQRLHD 121
E+ +++K A F + + L+ L+ QQL+ D
Sbjct: 1448 ELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKD 1507
Query: 122 IETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAE----------TI 171
+E K E L+E NK A + + KEK+ E Q L+ E +
Sbjct: 1508 LEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQV 1567
Query: 172 ALEKEQKLQNDFAEKER-----KLQETQMSTTSK-LEEAEHKVQSLQTALEKTRTELFDL 225
E E LQ AE E+ Q+ +M+ + L + ++ LQ ++ + + +L +
Sbjct: 1568 LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA 1627
Query: 226 KTKYDEETTAKADEIEMIMTDLE-----RANQRAEVAQREAE--TLREQLSSANHSLQLA 278
+ E T K + I + + LE + ++++R+ + +++++ +LQ+
Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVV 1687
Query: 279 SQIQKAPDVEQAIEVLTRSSLE-VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQ 337
+ Q + + +L LE EL + + Q V ++++ Q ++ + + + Q
Sbjct: 1688 LR-QMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE-EKLELENLQQ 1745
Query: 338 LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKS-MEFAPSEGAGTQDAAKPLEVLL 396
+ QQ + KQL E+ K + E + E L+S +E E Q+ E L
Sbjct: 1746 ISQQQKGEIEWQKQLLERDK--REIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
Query: 397 LEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQS-- 454
+ R L + ++ S+L EL VR + + +L L D+S +Q
Sbjct: 1804 AQTKRVLAAAEENSKMEQSNLEK--LELNVRKLQQELDQLNRDKL--SLHNDISAMQQQL 1859
Query: 455 IQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRA 514
++ +A + + L + + + A L E L IS RF
Sbjct: 1860 QEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE--QTRLQKDISEWANRF-- 1915
Query: 515 RNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQ 555
++ + E Q LQ LQ+E++ + +KL ++ Q
Sbjct: 1916 --EDCQKEEETKQQQLQVLQNEIEE---NKLKLVQQEMMFQ 1951
Score = 52.8 bits (125), Expect = 1e-06
Identities = 74/344 (21%), Positives = 150/344 (43%), Gaps = 44/344 (12%)
Query: 39 EQSRKRLIEQSREFKKNTPED-LRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLI 97
++ R++L + E ++P D L K +A L K F + L++ E + A + K
Sbjct: 814 DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFS---EILARSKWERDEAQVRERK--- 867
Query: 98 DVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKI 157
L +++ L+ ++L + E ++ E E F + + E I+ ++ +I
Sbjct: 868 ----------LQEEMALQQEKLATGQEEFRQACERALEARMNF-DKRQHEARIQQMENEI 916
Query: 158 REYEQTLKNQAETIALEKEQKLQNDFAEKERKL-QETQMSTTSKLEEAEHKVQ--SLQTA 214
++ LK+ E L Q LQ EKER L Q ++ KLE+A+ + Q L
Sbjct: 917 HYLQENLKSMEEIQGLTDLQ-LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
Query: 215 LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ-RAEVAQ------REAETLREQ 267
L+K + + E T D+++ + + + NQ RAE Q R+A
Sbjct: 976 LKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035
Query: 268 LSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKL 327
L+ A ++L + + + +E + ++ + ++ EI +L E ++R + + +L
Sbjct: 1036 LTRAEAEIELLQNLLRQKGEQFRLE-MEKTGVGTGANSQVLEIEKLNETMERQRTEIARL 1094
Query: 328 R--------------ENSASQISQLEQQLSAKNSTLKQLEEKLK 357
+ EN +I++L +++S +N + + + K
Sbjct: 1095 QNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFK 1138
Score = 49.7 bits (117), Expect = 9e-06
Identities = 74/370 (20%), Positives = 164/370 (44%), Gaps = 36/370 (9%)
Query: 19 QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78
+LQ+++ A + Q E E +++L E ++N + +++++ + + Q E
Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM--MFQRLQKE---- 1956
Query: 79 SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138
+E+E + L K + +L Q Q L + +++R TL+E
Sbjct: 1957 ----RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVR-TLQE--- 2008
Query: 139 EFAEVKNQEVTIKALKEKIREYEQTL-KNQAETIALEKE-QKLQNDFAEKERKLQETQMS 196
E ++ E T+ K ++ E EQ L + E +AL+KE ++ DF+ L Q
Sbjct: 2009 EERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS-----LLRNQFL 2063
Query: 197 TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 256
T K +AE +V SL+ AL+ R++L + +E + E+ I + ++RA
Sbjct: 2064 TERK--KAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121
Query: 257 AQREAETLREQLSSANHSLQLASQIQKAP-DVEQAIEVLTRSSLEVELAAKEREIAQLVE 315
+E ++ + + + +++ ++ A+ L +S ++ E+ + + Q +
Sbjct: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL-KSEVKDEIRTSLKNLNQFLP 2180
Query: 316 DV-----------QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 364
++ + L+ L L+EN +++ + S + ++E +G+A E+
Sbjct: 2181 ELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK 2240
Query: 365 VKKELNILKS 374
++ + LK+
Sbjct: 2241 LRHREDRLKA 2250
Score = 35.8 bits (81), Expect = 0.13
Identities = 55/249 (22%), Positives = 104/249 (41%), Gaps = 43/249 (17%)
Query: 20 LQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL--LKSFQGEI-D 76
+Q+E+ AT+ QD E++R+ + E ++ + T +L+KQ+A L+ Q EI D
Sbjct: 2101 IQKEM---ATIELVAQDNHERARRLMKELNQMQYEYT--ELKKQMANQKDLERRQMEISD 2155
Query: 77 ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL--- 133
A+ E + K L +PA L+ ++R ++E E + L+E L
Sbjct: 2156 AMRTLKSEVKDEIRTSLKNLNQFLPELPA-----DLEAILERNENLEGELESLKENLPFT 2210
Query: 134 -------EEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEK 186
E+ N + ++ +AL+EK+R E LK Q L++ +++
Sbjct: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ-----------LRHCMSKQ 2259
Query: 187 ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTD 246
L + + T L +V +L + T D ++ ++E +T+
Sbjct: 2260 AEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSA---------DSASSPSLSQLESSLTE 2310
Query: 247 LERANQRAE 255
+ Q E
Sbjct: 2311 DSQLGQNQE 2319
Score = 34.3 bits (77), Expect = 0.39
Identities = 108/515 (20%), Positives = 203/515 (39%), Gaps = 98/515 (19%)
Query: 138 KEFAEVKNQEVTIKA--------LKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 189
K+F ++N E +K L KI + ++ LK + ++ K K++
Sbjct: 113 KKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGI------- 165
Query: 190 LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK--------ADEIE 241
M KL A ++++ + L K L L K ++ ++ + D I
Sbjct: 166 ---ENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLIS 222
Query: 242 MIMTD-----LERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTR 296
+I+ + L Q R E+L Q Q A + +VE+ L +
Sbjct: 223 LILVENPVVTLPHYLQFTIFHLRSLESLEGQ-PVTTQDRQEAFERFSLEEVERLERDLEK 281
Query: 297 SSLEVE-LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQ--LE 353
+E E L +K+ + +++ +L SL + +L+ L+ KN LKQ +E
Sbjct: 282 KMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIE 341
Query: 354 EKLKGQADYEEVKKELNILK------SMEFAPSEGAGTQ--------------------- 386
Q Y E+++EL K + + PSE A
Sbjct: 342 LTRACQKQY-ELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFAT 400
Query: 387 -----DAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQREL 441
D+A+ +++ +E + L++++ LR ++ L + + + +I+ A +E +
Sbjct: 401 ESYIIDSAQAVQIKKMEPDEQLRNDHMNLR-GHTPLDTQLEDKEKKISAAQTRLSELHDE 459
Query: 442 IARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSL 501
I + EQ + + + + E A + L+KI E K+ L Y Q+
Sbjct: 460 IEKAEQQI-LRATEEFKQLEEAIQ--LKKISEAGKD---LLY------------KQLSGR 501
Query: 502 LSIISSQRERFRARNQELEAENRL-----AQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
L +++ R+ A + EL+ E + Q ++ LQ +DSL + + K +K +S
Sbjct: 502 LQLVNKLRQ--EALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPK-HSHMKAQKS 558
Query: 557 YPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQ 591
G+ D +Y Q E RLD S +E +
Sbjct: 559 --GKEQQLDIMNKQY-QQLESRLDEILSRIAKETE 590
Score = 32.3 bits (72), Expect = 1.5
Identities = 60/288 (20%), Positives = 121/288 (42%), Gaps = 65/288 (22%)
Query: 307 EREIAQLVEDVQRLQASLTKLRENSASQ----------------ISQLEQQLSAKNSTLK 350
E E+++L + +Q L++ + R AS+ + Q ++ L + L
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 351 QLEEKLKGQADY-----EEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS 405
+ +K + Q D+ E + EL I KS++ D + +E LL++ L+
Sbjct: 1382 RTVQKRQQQKDFIDGNVESLMTELEIEKSLK----HHEDIVDEIECIEKTLLKRRSELRE 1437
Query: 406 ENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQD------------LSIIQ 453
+ L + S+LS C + + + AV T+ + + + E D +++++
Sbjct: 1438 ADRLLAEAESELS--CTKEKTK--NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
Query: 454 SIQ-----RPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQ 508
+ Q + DA+ +H++ K E +KE + DS +S +
Sbjct: 1494 ADQQLRSLQADAKDLEQHKI-KQEEILKEINKIV-------------AAKDSDFQCLSKK 1539
Query: 509 RERFRARNQELEAENRLAQ----HTLQALQSELDSLRADNIKLFEKIK 552
+E+ Q+L+ + +A+ H LQ L+ L+A +L EK+K
Sbjct: 1540 KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAEL-EKLK 1586
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 80.1 bits (196), Expect = 6e-15
Identities = 104/475 (21%), Positives = 216/475 (45%), Gaps = 57/475 (12%)
Query: 20 LQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 74
LQ ++ A + L + ++ +Q K + + K+ T E++ ++ + + E
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 75 IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 134
L K + E V K + V +L ++L + + + E + L+E +
Sbjct: 948 CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEELSGLDETIAKLTREKKALQEAHQ 1005
Query: 135 EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
+ + +++ ++ K K+ + + L++ +LE+E+KL+ D +RKL+
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLES-----SLEQEKKLRVDLERNKRKLEGDL 1060
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 248
+ + E+ Q L L+K E L++K ++E T K E++ + +LE
Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120
Query: 249 RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAK-E 307
+ AE A R A+T +++ A +L+ ++++A V +S ++EL K E
Sbjct: 1121 EEIE-AERATR-AKTEKQRSDYARELEELSERLEEAGGV---------TSTQIELNKKRE 1169
Query: 308 REIAQLVEDVQRL----QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 363
E +L D++ +A + LR+ A +++L +Q+ L+++++KL + +
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI----DNLQRVKQKL--EKEKS 1223
Query: 364 EVKKELNIL-KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCA 422
E K E++ L SME A + + LE L E + +N ++ S S+L+ + +
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKS 1279
Query: 423 ELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKE 477
LQ TE EL +LE+ SI+ + R ++ A + E++ ++E
Sbjct: 1280 RLQ----------TEAGELSRQLEEKESIVSQLSR--SKQAFTQQTEELKRQLEE 1322
Score = 75.1 bits (183), Expect = 2e-13
Identities = 110/576 (19%), Positives = 227/576 (39%), Gaps = 51/576 (8%)
Query: 14 RFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQG 73
R DL++ + +A L + +S I+ + K+ ++ + F+
Sbjct: 1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--------FKL 1227
Query: 74 EIDALSKRSKEAEAAFLNVYKRLIDVPDPVP-ALDLGQQLQLKVQRLHDIETENQKLRET 132
EID LS + + N+ K + D + A +++Q + L ++ T+ +L+
Sbjct: 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ---RSLSELTTQKSRLQTE 1284
Query: 133 LEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 192
E +++ E ++ + K+ + + LK Q LE+E K +N A + +
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-----LEEENKAKNALAHALQSSRH 1339
Query: 193 TQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL----- 247
+ EE + LQ AL K +E+ +TKY+ + + +E+E L
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Query: 248 ------ERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEV 301
E N + ++ + L+ ++ ++ A+ + A D +Q + +
Sbjct: 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKT 1459
Query: 302 ELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTL--------KQLE 353
+ + E+ +++ + L L KL+ + QLE + +N L +Q+
Sbjct: 1460 KCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE-TVKRENKNLEQEIADLTEQIA 1518
Query: 354 EKLKGQADYEEVKKELNILKS---MEFAPSEGAGTQDAAKPLEVLL------LEKNRSLQ 404
E K + E+ +K++ + K+ + +E A + AK L + L E +R +
Sbjct: 1519 ENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIA 1578
Query: 405 SENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAA 464
++ + + +Q + V + E L ++E DL+ I+ AA
Sbjct: 1579 EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAA 1638
Query: 465 E--HRLEKIPEPIKEATALFYGPAAPASGALPE--GQVDSLLSIISSQRERFRARNQELE 520
E L + +K+ T L A L E V+ +++ ++ E RA ++ E
Sbjct: 1639 ETLKHLRSVQGQLKD-TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Query: 521 AENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS 556
+LA+ L + L N L K L++
Sbjct: 1698 RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733
Score = 70.5 bits (171), Expect = 5e-12
Identities = 98/498 (19%), Positives = 208/498 (41%), Gaps = 53/498 (10%)
Query: 119 LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 178
L ETE + + EE+ K E+ E K L+EK+ TL + + L+ + +
Sbjct: 841 LKSAETEKE-MATMKEEFQKTKDELAKSEAKRKELEEKL----VTLVQEKNDLQLQVQAE 895
Query: 179 LQN--DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 236
+N D E+ +L + + +K++E + + E+ EL K K ++E +
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSEL 951
Query: 237 ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--EQAIEVL 294
+I+ + L + + + + + L E+LS + ++ ++ +KA +QA++ L
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL 1011
Query: 295 TRSSLEVELAAKER-EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 353
+V K + ++ Q VED++ KLR + +LE L ++ LE
Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071
Query: 354 EKLKGQADYEEVKKEL---NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA- 409
K Q D KK+ + +E + G Q K L+ + E +++E A
Sbjct: 1072 ND-KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130
Query: 410 --LRISNSDLSGRCAELQVRITEAVATATEQREL-------IARLEQDL--------SII 452
SD + EL R+ EA + Q EL +L +DL +++
Sbjct: 1131 AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV 1190
Query: 453 QSIQRPDAEGAAE-----HRLEKIPEPIKEATALFYGPAAPASGAL-----PEGQVDSLL 502
++++ A+ AE L+++ + +++ + F S ++ + ++ +
Sbjct: 1191 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250
Query: 503 SIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGS 562
+ Q R +N+E+ Q +L L ++ L+ + +L +++ +S + S
Sbjct: 1251 RTLEDQLSEARGKNEEI-------QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 563 GSDDTELRYSSQYEERLD 580
S + + + + +L+
Sbjct: 1304 RSKQAFTQQTEELKRQLE 1321
Score = 53.1 bits (126), Expect = 8e-07
Identities = 57/254 (22%), Positives = 108/254 (42%), Gaps = 20/254 (7%)
Query: 16 DLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEI 75
++++L+ L+ T + E S +R+ Q + + +K++ L Q E+
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERV--QLLHTQNTSLIHTKKKLETDLMQLQSEV 1742
Query: 76 DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH-DIETENQKLRETLE 134
+ S+ ++ AE K + D L Q ++R+ ++E + L+ L+
Sbjct: 1743 EDASRDARNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1799
Query: 135 EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 194
E E +K + I+ L+ +IRE E LE EQK + + RK +
Sbjct: 1800 E--AEQLALKGGKKQIQKLETRIRELE---------FELEGEQKKNTESVKGLRKYERRV 1848
Query: 195 MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY---DEETTAKADEIEMIMTDLERAN 251
T + EE V LQ ++K + ++ K + DE+ A + +LE A
Sbjct: 1849 KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908
Query: 252 QRAEVAQREAETLR 265
+RA++A+ + LR
Sbjct: 1909 ERADIAESQVNKLR 1922
Score = 49.3 bits (116), Expect = 1e-05
Identities = 91/382 (23%), Positives = 174/382 (45%), Gaps = 64/382 (16%)
Query: 18 QQLQREL-DATATVLANRQD--ESEQSRKRLIEQSREFKKNTPED---LRKQVAPLLK-- 69
+ L++E+ D T + N + E E+SRK++ + + + E L + A +L+
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 70 ----SFQGEIDA-LSKRSKEAEAAFLNVYKRLIDVPDPVPALDL-----GQQLQLKVQR- 118
+ EID ++++ +E E N Y+R ++ ALD + ++LK +
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRN-YQRTVETMQS--ALDAEVRSRNEAIRLKKKME 1620
Query: 119 --LHDIETE----NQKLRETLEEYNKEFAEVKNQEVTIK-ALK--EKIREYEQTLKNQAE 169
L++IE + N++ ETL+ ++K+ ++ + AL+ E ++E ++ +A
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 170 TIALEKEQ-KLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTK 228
+ E E+ + + E+ RKL E + L ++ +VQ L T T L K K
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQE------LLDSNERVQLLHTQ----NTSLIHTKKK 1730
Query: 229 YDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVE 288
+ + E+E D A ++A+ A +A + E+L + +++K ++E
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK--NLE 1788
Query: 289 QAIEVLTRSSLEVE-LAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNS 347
Q ++ L E E LA K + + +Q+L+ T++RE LE +L +
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGK-----KQIQKLE---TRIRE--------LEFELEGEQ- 1831
Query: 348 TLKQLEEKLKGQADYEEVKKEL 369
K+ E +KG YE KEL
Sbjct: 1832 --KKNTESVKGLRKYERRVKEL 1851
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,236,975
Number of Sequences: 37866
Number of extensions: 908154
Number of successful extensions: 12752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 1238
Number of HSP's that attempted gapping in prelim test: 5271
Number of HSP's gapped (non-prelim): 4565
length of query: 678
length of database: 18,247,518
effective HSP length: 109
effective length of query: 569
effective length of database: 14,120,124
effective search space: 8034350556
effective search space used: 8034350556
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.