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Search of human proteins with 31377634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31377634 guanylate binding protein 4 [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31377634 guanylate binding protein 4 [Homo sapiens] 1264 0.0
gi|148234215 guanylate binding protein 4-like [Homo sapiens] 959 0.0
gi|157671915 guanylate binding protein family, member 6 [Homo sa... 877 0.0
gi|166706903 guanylate binding protein 1, interferon-inducible, ... 647 0.0
gi|38327558 guanylate binding protein 2, interferon-inducible [H... 634 0.0
gi|112382372 guanylate binding protein 3 [Homo sapiens] 633 0.0
gi|197333737 guanylate-binding protein 5 [Homo sapiens] 588 e-168
gi|16418425 guanylate-binding protein 5 [Homo sapiens] 588 e-168
gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [... 102 1e-21
gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens] 77 6e-14
gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens] 77 6e-14
gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens] 77 6e-14
gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens] 74 3e-13
gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens] 74 3e-13
gi|45827806 atlastin 3 [Homo sapiens] 69 1e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 5e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 60 6e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 59 1e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 59 2e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 59 2e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 59 2e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 59 2e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 59 2e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 59 2e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 59 2e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 59 2e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 58 2e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 58 2e-08
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 58 2e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 58 3e-08
>gi|31377634 guanylate binding protein 4 [Homo sapiens]
Length = 640
Score = 1264 bits (3272), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVG 60
MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVG
Sbjct: 1 MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVG 60
Query: 61 LYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVE 120
LYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVE
Sbjct: 61 LYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVE 120
Query: 121 KSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAED 180
KSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAED
Sbjct: 121 KSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAED 180
Query: 181 SSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIR 240
SSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIR
Sbjct: 181 SSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIR 240
Query: 241 HFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGI 300
HFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGI
Sbjct: 241 HFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGI 300
Query: 301 IVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLP 360
IVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLP
Sbjct: 301 IVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLP 360
Query: 361 TDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKY 420
TDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKY
Sbjct: 361 TDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKY 420
Query: 421 CQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQ 480
CQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQ
Sbjct: 421 CQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQ 480
Query: 481 SQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQE 540
SQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQE
Sbjct: 481 SQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQE 540
Query: 541 YMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIEST 600
YMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIEST
Sbjct: 541 YMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIEST 600
Query: 601 KNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI 640
KNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI
Sbjct: 601 KNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI 640
>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
Length = 638
Score = 959 bits (2480), Expect = 0.0
Identities = 484/622 (77%), Positives = 547/622 (87%), Gaps = 1/622 (0%)
Query: 18 SESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKR 77
SE M P+CL EN + L VNS+ALEIL I+QPVVVVAIVGLYRTGKSYLMN+LAGK
Sbjct: 3 SEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKN 62
Query: 78 NGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLL 137
GFPLG TV+SETKGIWMWCVPH SKPNHTL+LLDTEGLGD+EKS+PK+DSWIFALAVLL
Sbjct: 63 KGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLL 122
Query: 138 SSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRD 197
SSSFVYNS+ TINHQALEQLHYVTEL ELIRAKSCPRPDE EDSSEF SFFPDFIWTVRD
Sbjct: 123 SSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRD 182
Query: 198 FTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTND 257
FTLELKLDG+PITEDEYLENALKLI GKNP+IQNSN PRE IRHFF K+KCFVFDRP ND
Sbjct: 183 FTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPIND 242
Query: 258 KQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDA 317
K+ L H++EV E+ L+ +F MQS+NFCSYIFTHAKTKTLREGI+VTG RLG LV TY+DA
Sbjct: 243 KKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDA 302
Query: 318 INSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACERE 377
INSGA PCLENA+ LAQ EN AAVQRAA+HYSQQMAQQ+R PTDTLQELLDVHA CERE
Sbjct: 303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCERE 362
Query: 378 AIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESIL 437
AIAVFME+SFKD++ EFQKKLVDT+EKKK DFVLQNEEASAKYCQAELKRLSE LTESI
Sbjct: 363 AIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESIS 422
Query: 438 RGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALT 497
RG F VPGGHN+YLE KK++E DY LVPRKGVKA+EVLQ+FLQSQVV+EESILQSDKALT
Sbjct: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
Query: 498 AGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLL 557
AGEKAIAA++A KEAAEKEQELLR+KQKEQQQMMEAQERSFQE +AQ++KK+E EREN +
Sbjct: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYM 542
Query: 558 REHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLL-KILDMASN 616
RE ++L HK+KV EE+L E F++ E LN+EIN+LKE+IE+ +NE+ + +ILD+A +
Sbjct: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGS 602
Query: 617 IMIVTLPGASKLLGVGTKYLGS 638
I I LPGA+KL+ +G K L S
Sbjct: 603 IFIAALPGAAKLVDLGMKILSS 624
>gi|157671915 guanylate binding protein family, member 6 [Homo
sapiens]
Length = 633
Score = 877 bits (2266), Expect = 0.0
Identities = 440/623 (70%), Positives = 520/623 (83%), Gaps = 1/623 (0%)
Query: 17 ESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGK 76
ES M+AP+CLVEN EQL VN +A++IL+KISQPVVVVAIVGLYRTGKSYLMN LAG+
Sbjct: 2 ESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQ 61
Query: 77 RNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVL 136
+GFPLGSTVQSETKGIWMWCVPH SKPNHTLVLLDTEGLGDVEK +PKNDSWIFALAVL
Sbjct: 62 NHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVL 121
Query: 137 LSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVR 196
L S+FVYNS+STINHQALEQLHYVTEL ELI+AKS PRPD EDS+EF SFFPDF+WTVR
Sbjct: 122 LCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVR 181
Query: 197 DFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTN 256
DFTLELKL+G+PITEDEYLENALKLI G NP++Q SN PRECIR FF KRKCFVFDRPTN
Sbjct: 182 DFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTN 241
Query: 257 DKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVD 316
DK L ++++V E+ L+ F Q++ FCSYIFTHA+TKTLREGI VTG RLGTL VTYV+
Sbjct: 242 DKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVE 301
Query: 317 AINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACER 376
AINSGAVPCLENAV LAQ EN AAVQRAAD+YSQQMAQ+++LPTDTLQELLD+HAACER
Sbjct: 302 AINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACER 361
Query: 377 EAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESI 436
EAIA+FMEHSFKDEN EFQKK ++T KKGDF+LQNEE+S +YCQA+L LS+ L ESI
Sbjct: 362 EAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESI 421
Query: 437 LRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
G FSVPGGH LY+E K+++E DY VPRKGVKA EV Q FL+SQ+V+EESILQSDKAL
Sbjct: 422 SAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKAL 481
Query: 497 TAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENL 556
T EKA+A +RA KEAAEKEQELL++K +EQQQ MEAQ++S +E +AQ+++KL+ ERE+L
Sbjct: 482 TDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHL 541
Query: 557 LREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR-LLKILDMAS 615
LRE +L+H KVQ + L E F+KK E++N EI+Q K I++TKN+ + + LD +
Sbjct: 542 LREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLA 601
Query: 616 NIMIVTLPGASKLLGVGTKYLGS 638
+ + L +KL+G G K + S
Sbjct: 602 DELTAILSAPAKLIGHGVKGVSS 624
>gi|166706903 guanylate binding protein 1, interferon-inducible,
67kDa [Homo sapiens]
Length = 592
Score = 647 bits (1668), Expect = 0.0
Identities = 325/586 (55%), Positives = 437/586 (74%), Gaps = 3/586 (0%)
Query: 18 SESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKR 77
SE M P+CL+EN +L N +AL+IL I+QP+VVVAIVGLYRTGKSYLMN+LAGK+
Sbjct: 3 SEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKK 62
Query: 78 NGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLL 137
GF LGSTVQS TKGIWMWCVPH KP H LVLLDTEGLGDVEK + +NDSWIFALAVLL
Sbjct: 63 KGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLL 122
Query: 138 SSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCP--RPDEAEDSSEFASFFPDFIWTV 195
SS+FVYNS+ TIN QA++QL+YVTEL IR+KS P +E EDS++F SFFPDF+WT+
Sbjct: 123 SSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTL 182
Query: 196 RDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPT 255
RDF+L+L+ DG P+T DEYL +LKL G + K + N+PR CIR FF K+KCFVFDRP
Sbjct: 183 RDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPV 242
Query: 256 NDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYV 315
+ ++ L ++++ +E L+ F+ Q +FCSYIF+++KTKTL GI V G RL +LV+TYV
Sbjct: 243 HRRK-LAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYV 301
Query: 316 DAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACE 375
+AI+SG +PC+ENAV ALAQ+EN AAVQ+A HY QQM Q+++LPT+TLQELLD+H E
Sbjct: 302 NAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSE 361
Query: 376 REAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTES 435
REAI VF+ SFKD +H FQK+L +EKK+ DF QN+EAS+ C A L+ + L E
Sbjct: 362 REAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEE 421
Query: 436 ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKA 495
+ GI+S PGG+ L++++ + ++ Y PRKG++A E+LQ +L+S+ + ++ILQ+D+
Sbjct: 422 VKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQT 481
Query: 496 LTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEEREN 555
LT EK I ER E+A+ ++L+E Q++ +QMME +ERS+QE++ Q+ +K+E +R
Sbjct: 482 LTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQ 541
Query: 556 LLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTK 601
LL+E ER L KL+ QE++LKE FQK+S + EI L+ K+ K
Sbjct: 542 LLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRK 587
>gi|38327558 guanylate binding protein 2, interferon-inducible [Homo
sapiens]
Length = 591
Score = 634 bits (1635), Expect = 0.0
Identities = 316/575 (54%), Positives = 434/575 (75%), Gaps = 1/575 (0%)
Query: 25 PICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGS 84
P+ L++N + QL VN +AL+IL I+QPVVVVAIVGLYRTGKSYLMN+LAGK+NGF LGS
Sbjct: 10 PMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGS 69
Query: 85 TVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYN 144
TV+S TKGIWMWCVPH KP HTLVLLDTEGLGD+EK + +NDSWIFALA+LLSS+FVYN
Sbjct: 70 TVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYN 129
Query: 145 SVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKL 204
S+ TIN QA++QLHYVTEL + I+A S P + +DS++F SFFP F+WT+RDFTLEL++
Sbjct: 130 SMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEV 189
Query: 205 DGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHM 264
DG PIT D+YLE +LKL G + K ++ N PR CIR FF KRKCFVFD P K+YL H+
Sbjct: 190 DGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA-PKKYLAHL 248
Query: 265 DEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVP 324
+++ EE L F+ Q FCSYI +H+ KTL GI V G RL +LV+TYV+AI+SG +P
Sbjct: 249 EQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLP 308
Query: 325 CLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFME 384
C+ENAV ALAQ+EN AAV++A HY QQM Q+++LPT+TLQELLD+H EREAI VFM+
Sbjct: 309 CMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMK 368
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+SFKD + FQ+KL +E ++ DF QN +AS+ C A L+ + L E + +G FS P
Sbjct: 369 NSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKP 428
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
GG+ L+ ++ ++++ Y VPRKG++A EVL+ +L+S+ V +++LQ+D++L+ EKAI
Sbjct: 429 GGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIE 488
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLL 564
ER E+AE +++L E QK+ ++MME +E+S+QE++ Q+ +K+E +R L+ E E+ L
Sbjct: 489 VERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTL 548
Query: 565 KHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIES 599
KL+ QE +LKE F+ +S++L K+I ++ + +S
Sbjct: 549 ALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKS 583
>gi|112382372 guanylate binding protein 3 [Homo sapiens]
Length = 595
Score = 633 bits (1632), Expect = 0.0
Identities = 320/590 (54%), Positives = 432/590 (73%), Gaps = 2/590 (0%)
Query: 22 MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFP 81
M P+CL+EN +L N +AL+IL I+QPVVVVAIVGLYRTGKSYLMN+LAGK GF
Sbjct: 7 MTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
Query: 82 LGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSF 141
LGSTV+S TKGIWMWCVPH KP HTLVLLDTEGLGDV+K + +NDSWIF LAVLLSS+
Sbjct: 67 LGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTL 126
Query: 142 VYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201
VYNS+ TIN QA++QL+YVTEL IR+KS P +E EDS++F SFFPDF+WT+RDF+L+
Sbjct: 127 VYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLD 186
Query: 202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYL 261
L+ DG P+T DEYLE +LKL G + K +N N+PR CIR FF K+KCFVFD P + ++ L
Sbjct: 187 LEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIH-RRKL 245
Query: 262 NHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSG 321
++++ +E L+ F+ Q +FCSYIF+++KTKTL GI V G RL +LV+TY++AI+ G
Sbjct: 246 AQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRG 305
Query: 322 AVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
+PC+ENAV ALAQ+EN AAVQ+A HY QQM Q+++LP +TLQELLD+H EREA V
Sbjct: 306 DLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEV 365
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+M++SFKD +H FQKKL ++KK+ DF QN+EAS+ C A L+ + L E + GI+
Sbjct: 366 YMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIY 425
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEK 501
S PGG+ L++++ + +E Y PRKG++A E+LQ +L+S+ V ++ILQ+D+ LT EK
Sbjct: 426 SKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEK 485
Query: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561
I E E+A+ +++ E Q + QQMME +E+S+QE++ Q+ +K+E ER LL E E
Sbjct: 486 EIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQE 545
Query: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKI-ESTKNEQLRLLKI 610
+ L KL+ Q +LKE Q +S QL EI +L++ + + TK LKI
Sbjct: 546 KTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
>gi|197333737 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 588 bits (1515), Expect = e-168
Identities = 298/578 (51%), Positives = 412/578 (71%), Gaps = 5/578 (0%)
Query: 22 MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFP 81
M P+CL+EN EQL VN +ALEIL I+QPVVVVAIVGLYRTGKSYLMN+LAGK GF
Sbjct: 7 MSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
Query: 82 LGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSF 141
+ STVQS TKGIW+WCVPH + PNHTLVLLDTEGLGDVEK++ KND IFALA+LLSS+F
Sbjct: 67 VASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTF 126
Query: 142 VYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201
VYN+V+ I+ A++ LH VTEL +L++A++ P D ED ++ ASFFPD +WT+RDF L
Sbjct: 127 VYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLG 186
Query: 202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYL 261
L++DG +T DEYLEN+L+ G + ++QN N+PR CI+ FF K+KCF+FD P + K+ L
Sbjct: 187 LEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKK-L 245
Query: 262 NHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSG 321
++ +P++ LE F+ Q FCSYIF+H+ TKTL GI+V G RL LV+TYV+AI+SG
Sbjct: 246 AQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSG 305
Query: 322 AVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
+PC+ENAV ALAQ EN AAVQ+A HY QQM Q+++LP +TLQELLD+H EREAI V
Sbjct: 306 DLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEV 365
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
FM++SFKD + FQK+L ++ K+ D +N EAS+ YC A LK + L E++ +GI+
Sbjct: 366 FMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIY 425
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEK 501
S PGGHNL++++ ++++ Y PRKG++A EVLQ +L+S+ V +ILQ+D+ALT EK
Sbjct: 426 SKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK 485
Query: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561
+ EA + E + L Q++ +QMM+ +ER QE + QM E ++N L E +
Sbjct: 486 KKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQM----EIAKQNWLAEQQ 541
Query: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIES 599
++ + +++ Q L FQ ++ L E+ + + +
Sbjct: 542 KMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN 579
>gi|16418425 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 588 bits (1515), Expect = e-168
Identities = 298/578 (51%), Positives = 412/578 (71%), Gaps = 5/578 (0%)
Query: 22 MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFP 81
M P+CL+EN EQL VN +ALEIL I+QPVVVVAIVGLYRTGKSYLMN+LAGK GF
Sbjct: 7 MSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
Query: 82 LGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSF 141
+ STVQS TKGIW+WCVPH + PNHTLVLLDTEGLGDVEK++ KND IFALA+LLSS+F
Sbjct: 67 VASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTF 126
Query: 142 VYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201
VYN+V+ I+ A++ LH VTEL +L++A++ P D ED ++ ASFFPD +WT+RDF L
Sbjct: 127 VYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLG 186
Query: 202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYL 261
L++DG +T DEYLEN+L+ G + ++QN N+PR CI+ FF K+KCF+FD P + K+ L
Sbjct: 187 LEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKK-L 245
Query: 262 NHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSG 321
++ +P++ LE F+ Q FCSYIF+H+ TKTL GI+V G RL LV+TYV+AI+SG
Sbjct: 246 AQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSG 305
Query: 322 AVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
+PC+ENAV ALAQ EN AAVQ+A HY QQM Q+++LP +TLQELLD+H EREAI V
Sbjct: 306 DLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEV 365
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
FM++SFKD + FQK+L ++ K+ D +N EAS+ YC A LK + L E++ +GI+
Sbjct: 366 FMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIY 425
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEK 501
S PGGHNL++++ ++++ Y PRKG++A EVLQ +L+S+ V +ILQ+D+ALT EK
Sbjct: 426 SKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEK 485
Query: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561
+ EA + E + L Q++ +QMM+ +ER QE + QM E ++N L E +
Sbjct: 486 KKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQM----EIAKQNWLAEQQ 541
Query: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIES 599
++ + +++ Q L FQ ++ L E+ + + +
Sbjct: 542 KMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN 579
>gi|169160863 PREDICTED: similar to guanylate-binding protein 5
[Homo sapiens]
Length = 112
Score = 102 bits (253), Expect = 1e-21
Identities = 51/67 (76%), Positives = 58/67 (86%), Gaps = 1/67 (1%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENH 392
LAQ EN A+QRAA+HYSQQMAQ++R PTD LQELLD+H ACEREAIAVFMEHS + EN
Sbjct: 3 LAQRENSVALQRAANHYSQQMAQRMRFPTDMLQELLDMHTACEREAIAVFMEHS-RGENQ 61
Query: 393 EFQKKLV 399
EFQKKL+
Sbjct: 62 EFQKKLM 68
>gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 76.6 bits (187), Expect = 6e-14
Identities = 88/388 (22%), Positives = 165/388 (42%), Gaps = 51/388 (13%)
Query: 53 VVVVAIVGLYRTGKSYLMNRL------------AGKRN----GFPLGSTVQSETKGIWMW 96
VV V++ G +R GKS+LM+ + G N GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 97 CVPHL-SKPNH---TLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQ 152
L +KP+ ++L+DT+G D +S ++ + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 153 ALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITED 212
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 213 EYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP----TNDKQYLNHMDEVP 268
++LE LK+ ++ ++QN R+ I F CF+ P + + + E+
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEID 290
Query: 269 EENLERHFLMQSDNFCSYIFTHAKTKTLRE--GIIVTGKRLGTLVVTYVDAINSGAVPCL 326
+E F+ ++ + ++ ++E G +T + L Y+ +P
Sbjct: 291 DE-----FIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHP 344
Query: 327 ENAVTALAQLENPAAVQRAADHYSQQMAQQL--RLPTDTLQELLDVHAACEREAIAVFME 384
++ + A A+ N AAV A D Y+++M + P +L H + E++ +F
Sbjct: 345 KSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRG 404
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQ 412
K EF ++ + +E + + +Q
Sbjct: 405 VK-KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 76.6 bits (187), Expect = 6e-14
Identities = 88/388 (22%), Positives = 165/388 (42%), Gaps = 51/388 (13%)
Query: 53 VVVVAIVGLYRTGKSYLMNRL------------AGKRN----GFPLGSTVQSETKGIWMW 96
VV V++ G +R GKS+LM+ + G N GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 97 CVPHL-SKPNH---TLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQ 152
L +KP+ ++L+DT+G D +S ++ + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 153 ALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITED 212
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 213 EYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP----TNDKQYLNHMDEVP 268
++LE LK+ ++ ++QN R+ I F CF+ P + + + E+
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEID 290
Query: 269 EENLERHFLMQSDNFCSYIFTHAKTKTLRE--GIIVTGKRLGTLVVTYVDAINSGAVPCL 326
+E F+ ++ + ++ ++E G +T + L Y+ +P
Sbjct: 291 DE-----FIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHP 344
Query: 327 ENAVTALAQLENPAAVQRAADHYSQQMAQQL--RLPTDTLQELLDVHAACEREAIAVFME 384
++ + A A+ N AAV A D Y+++M + P +L H + E++ +F
Sbjct: 345 KSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRG 404
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQ 412
K EF ++ + +E + + +Q
Sbjct: 405 VK-KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens]
Length = 558
Score = 76.6 bits (187), Expect = 6e-14
Identities = 88/388 (22%), Positives = 165/388 (42%), Gaps = 51/388 (13%)
Query: 53 VVVVAIVGLYRTGKSYLMNRL------------AGKRN----GFPLGSTVQSETKGIWMW 96
VV V++ G +R GKS+LM+ + G N GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 97 CVPHL-SKPNH---TLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQ 152
L +KP+ ++L+DT+G D +S ++ + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 153 ALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITED 212
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 213 EYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP----TNDKQYLNHMDEVP 268
++LE LK+ ++ ++QN R+ I F CF+ P + + + E+
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEID 290
Query: 269 EENLERHFLMQSDNFCSYIFTHAKTKTLRE--GIIVTGKRLGTLVVTYVDAINSGAVPCL 326
+E F+ ++ + ++ ++E G +T + L Y+ +P
Sbjct: 291 DE-----FIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHP 344
Query: 327 ENAVTALAQLENPAAVQRAADHYSQQMAQQL--RLPTDTLQELLDVHAACEREAIAVFME 384
++ + A A+ N AAV A D Y+++M + P +L H + E++ +F
Sbjct: 345 KSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRG 404
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQ 412
K EF ++ + +E + + +Q
Sbjct: 405 VK-KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens]
Length = 583
Score = 74.3 bits (181), Expect = 3e-13
Identities = 101/438 (23%), Positives = 181/438 (41%), Gaps = 53/438 (12%)
Query: 18 SESIMMAP----ICLVENQEEQLTVNSKALE---ILDKISQ-PVVVVAIVGLYRTGKSYL 69
S+ +M P I L + ++ +ALE + + I +VVV++ G +R GKS+L
Sbjct: 51 SDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFL 110
Query: 70 MNRLA------------GKRN----GFPLGSTVQSETKGIWMWC-VPHLSKPNHTLV--- 109
++ + G N GF + ET GI +W V + +PN T V
Sbjct: 111 LDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVL 170
Query: 110 LLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRA 169
L+DT+G D +S K+ + +FAL+ + SS VYN I L+ L TE L
Sbjct: 171 LMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAME 229
Query: 170 KSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKI 229
+ +P F ++ +RD++ + ++LE L++ ++ ++
Sbjct: 230 EIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEEL 277
Query: 230 QNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFT 289
QN R+ I + F CF+ P K N + ++++ F + N +
Sbjct: 278 QN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLA 333
Query: 290 HAK-TKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADH 348
+ G VT + L Y+ +P ++ + A A+ N AAV A D
Sbjct: 334 PENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDT 393
Query: 349 YSQQMAQ------QLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTI 402
Y + M Q P+D ++ LD+ ++ +V + + +Q +L I
Sbjct: 394 YCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKMGGDEFCRRYQDQLEAEI 452
Query: 403 EKKKGDFVLQNEEASAKY 420
E+ +F+ N+ + Y
Sbjct: 453 EETYANFIKHNDGKNIFY 470
>gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens]
Length = 579
Score = 74.3 bits (181), Expect = 3e-13
Identities = 101/438 (23%), Positives = 181/438 (41%), Gaps = 53/438 (12%)
Query: 18 SESIMMAP----ICLVENQEEQLTVNSKALE---ILDKISQ-PVVVVAIVGLYRTGKSYL 69
S+ +M P I L + ++ +ALE + + I +VVV++ G +R GKS+L
Sbjct: 51 SDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFL 110
Query: 70 MNRLA------------GKRN----GFPLGSTVQSETKGIWMWC-VPHLSKPNHTLV--- 109
++ + G N GF + ET GI +W V + +PN T V
Sbjct: 111 LDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVL 170
Query: 110 LLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRA 169
L+DT+G D +S K+ + +FAL+ + SS VYN I L+ L TE L
Sbjct: 171 LMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAME 229
Query: 170 KSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKI 229
+ +P F ++ +RD++ + ++LE L++ ++ ++
Sbjct: 230 EIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEEL 277
Query: 230 QNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFT 289
QN R+ I + F CF+ P K N + ++++ F + N +
Sbjct: 278 QN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLA 333
Query: 290 HAK-TKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADH 348
+ G VT + L Y+ +P ++ + A A+ N AAV A D
Sbjct: 334 PENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDT 393
Query: 349 YSQQMAQ------QLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTI 402
Y + M Q P+D ++ LD+ ++ +V + + +Q +L I
Sbjct: 394 YCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKMGGDEFCRRYQDQLEAEI 452
Query: 403 EKKKGDFVLQNEEASAKY 420
E+ +F+ N+ + Y
Sbjct: 453 EETYANFIKHNDGKNIFY 470
>gi|45827806 atlastin 3 [Homo sapiens]
Length = 541
Score = 69.3 bits (168), Expect = 1e-11
Identities = 102/427 (23%), Positives = 172/427 (40%), Gaps = 62/427 (14%)
Query: 26 ICLVENQEEQLTVNSKALEIL---DKISQ-PVVVVAIVGLYRTGKSYLMNRL-------- 73
+ LV+ + ++ KAL + D I VVVV++ G +R GKS++++ +
Sbjct: 29 VVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFILDFMLRYLYSQK 88
Query: 74 -AGKRN----------GFPLGSTVQSETKGIWMWC-VPHLSKPNH---TLVLLDTEGLGD 118
+G N GF ET GI +W V + KP +VL+DT+G D
Sbjct: 89 ESGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVAVVLMDTQGAFD 148
Query: 119 VEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEA 178
+S K+ + IFAL+ + SS +YN I L+QL TE L + +P
Sbjct: 149 -SQSTVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLAMDEIFQKP--- 204
Query: 179 EDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPREC 238
F ++ VRD++ + +L+ L++ ++ +IQN R
Sbjct: 205 ---------FQTLMFLVRDWSFPYEYSYGLQGGMAFLDKRLQVKEHQHEEIQN---VRNH 252
Query: 239 IRHFFRKRKCFVFDRPTNDKQYLNHMD-EVPEENLERHFLMQSDNFCSYIFTHAKTKTLR 297
I F CF+ P Q D + +++ F Q Y+ +K
Sbjct: 253 IHSCFSDVTCFLLPHP--GLQVATSPDFDGKLKDIAGEFKEQLQALIPYVLNPSKLMEKE 310
Query: 298 -EGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQM--- 353
G VT + L Y+ +P ++ + A A+ N AA A D Y M
Sbjct: 311 INGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAEANNLAAAASAKDIYYNNMEEV 370
Query: 354 --AQQLRLPTDTLQELLDVHAACEREAIAV-----FMEHSFKDENHEFQKKLVDTIEKKK 406
++ L D L+E CE + +A+ + KD + +Q++L + I++
Sbjct: 371 CGGEKPYLSPDILEE-----KHCEFKQLALDHFKKTKKMGGKDFSFRYQQELEEEIKELY 425
Query: 407 GDFVLQN 413
+F N
Sbjct: 426 ENFCKHN 432
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 60.5 bits (145), Expect = 5e-09
Identities = 58/240 (24%), Positives = 118/240 (49%), Gaps = 27/240 (11%)
Query: 388 KDENHEFQKKLVDTIEKK-KGDFVLQNEEASAKYCQAELKRLSEHLTES--ILRGIFSVP 444
K++ HE ++K+ EK + + ++ +E + + ++ R E + E + R +
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
++ EEK+Q + D R+ K E + + + + E Q +K EK
Sbjct: 555 EQEKIWEEEKRQEQEDKMW--RQEEKIREQEEKVWRQEEKIRE---QEEKRQEQEEKMWK 609
Query: 505 AERAMKEAAEK---EQELLREKQ---KEQQQMMEAQERSF---QEYMAQMEKKLEEEREN 555
E ++E EK ++E +RE++ +EQ++M + QE +E M + E+K++E+ E
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669
Query: 556 LLREHERL---------LKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR 606
+ R+ E++ + K++ QEEM++E+ +K EQ K Q +EK++ + + R
Sbjct: 670 MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-EEKMQEQEEKMRR 728
Score = 55.8 bits (133), Expect = 1e-07
Identities = 70/298 (23%), Positives = 137/298 (45%), Gaps = 36/298 (12%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQ-------LRLPTDTLQELLDVHAACEREA 378
LE A++A+A ++ AD Y +++ ++ L T T +EL + +A + +
Sbjct: 177 LEQALSAVA------TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 230
Query: 379 IAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLT----E 434
V E K E K+L +E+ K Q +A A + EL+ +S L E
Sbjct: 231 QLVESE---KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 435 SILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDK 494
+ L + ++ +E+K EW+ K+ ++ K E + + + E+ Q +
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEE-KIREQEEKIREQE---EKMRRQEEM 343
Query: 495 ALTAGEKAIAAERAMKEAAEK---EQELL---REKQKEQQQMMEAQERSFQEYMAQMEKK 548
EK E M E EK ++E++ EK + Q++MM +E +E +E+K
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE----LEEK 399
Query: 549 LEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR 606
+ E+ + +RE E + + K++E+ ++E + K + ++I + +EKI + + R
Sbjct: 400 MHEQEK--IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 455
Score = 51.6 bits (122), Expect = 2e-06
Identities = 68/317 (21%), Positives = 143/317 (45%), Gaps = 54/317 (17%)
Query: 318 INSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACERE 377
IN+G P T +P Q+A+ + + + ++L T++ L C++
Sbjct: 90 INNGTNP----ETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRIL-----TCQKT 140
Query: 378 AIAV---FMEHSFKD---ENHEFQKKLVDT---------------IEKKKGDFVLQNEEA 416
+ + + +H+ K E + +L D+ +KKK D + EE
Sbjct: 141 ELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYI--EEL 198
Query: 417 SAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQ 476
+ + L+ +T+ L+ N L+EK Q+ K + VK E+ +
Sbjct: 199 TKERDALSLELYRNTITDEELKE-------KNAKLQEKLQLVESEKSEIQLNVK--ELKR 249
Query: 477 NFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQER 536
++++++ + LQ++ K + + A +A +E EL ++Q++ M QE
Sbjct: 250 KLERAKLLLPQQQLQAEADHLG--KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 307
Query: 537 SFQEYMAQMEKKLEEERENLLREHERLLKH--KLKVQEEML--KEEFQKKSEQL---NKE 589
QE+ E+K++E+ E + + E++ + K++ QEEM+ KEE ++ E++ +E
Sbjct: 308 KIQEW----EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 590 INQLKEKIESTKNEQLR 606
+ +E++ K E++R
Sbjct: 364 KMRRQEEMMWEKEEKMR 380
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/147 (25%), Positives = 77/147 (52%), Gaps = 22/147 (14%)
Query: 449 LYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERA 508
++ +E+K E + K+ ++ K E + + + + +E Q +K EK E
Sbjct: 607 MWKQEEKIREQEEKIQEQEE-KIREQEEKIREQEEMTQE---QEEKMGEQEEKMCEQEEK 662
Query: 509 MKEAAE---KEQELLREKQK----------EQQQMMEAQERSF---QEYMAQMEKKLEEE 552
M+E E +++E +RE++K EQ++MM+ QE +E M + E+K++E+
Sbjct: 663 MQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 722
Query: 553 RENLLREHERLLKH--KLKVQEEMLKE 577
E + R+ E++ + +L+ QEE ++E
Sbjct: 723 EEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 48.1 bits (113), Expect = 2e-05
Identities = 26/119 (21%), Positives = 69/119 (57%), Gaps = 5/119 (4%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQM 545
EE + + ++ + E+ + + ++E EK QE + +++E++Q EA+ +E + +
Sbjct: 383 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Query: 546 EKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
E+K+ E+ + + R+ E K+ QE++ +EE +++ E++ ++ ++ E+ E + ++
Sbjct: 443 EEKIREQEKKMWRQEE-----KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE 496
Score = 46.6 bits (109), Expect = 7e-05
Identities = 38/163 (23%), Positives = 85/163 (52%), Gaps = 10/163 (6%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVE-ESILQSDKALTAGEKAIAAERAMK 510
E+++++ +++ K K E+ + + + + E E Q ++ + EK E M
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433
Query: 511 EAAEKEQELLREKQKEQQQMMEAQERSF--QEYMAQMEKKLEEE----RENLLREHERLL 564
EK +E EK +EQ++ M QE QE + + EK+ E+E +E + E E +
Sbjct: 434 RQEEKIREQ-EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 565 KHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ K K+ E+ +E+ +K+ E++ ++ +++E+ E + ++ ++
Sbjct: 493 RQKEKMHEQ--EEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533
Score = 45.8 bits (107), Expect = 1e-04
Identities = 51/230 (22%), Positives = 111/230 (48%), Gaps = 25/230 (10%)
Query: 388 KDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGH 447
+++ HE Q+K+ + EK++ + ++ +E + +A++ R E + E
Sbjct: 397 EEKMHE-QEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQ----------EE 444
Query: 448 NLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAER 507
+ +EKK + K+ ++ ++ E Q + EE I + ++ EK E
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQE-QEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 508 AMKEAAEK---EQELLREKQ---KEQQQMMEAQERSF--QEYMAQMEKKLEEERENLLRE 559
+++ EK ++E +RE++ +EQ++ M QE QE M + E+K+ E+ + E
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 560 HERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLK 609
+ + K+ QEE ++E+ +K Q K ++E+ E + ++ ++ K
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEK----IREQEEKRQEQEEKMWK 609
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/153 (23%), Positives = 77/153 (50%), Gaps = 7/153 (4%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAG--EKAIAAERAM 509
EEK+Q + + + ++ E + ++ +E ++ + +T EK E M
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656
Query: 510 KEAAEK--EQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLL--K 565
E EK EQE +Q+E+ + E + R +E + + E+ ++E+ E + + E++ +
Sbjct: 657 CEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 716
Query: 566 HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIE 598
K++ QEE ++ + +K EQ + Q +EK++
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQ-EVRLRQQEEKMQ 748
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/115 (25%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKE 511
+E+K E + K+ ++ E +Q ++ EE I + +K + E+ I + M +
Sbjct: 645 QEEKMGEQEEKMCEQE-----EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699
Query: 512 AAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKH 566
E++ EK EQ++ M+ QE E M + E+K+ E+ L ++ E++ +H
Sbjct: 700 EQEEKMWEQEEKMCEQEEKMQEQE----EKMRRQEEKMWEQEVRLRQQEEKMQEH 750
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 60.1 bits (144), Expect = 6e-09
Identities = 57/236 (24%), Positives = 113/236 (47%), Gaps = 29/236 (12%)
Query: 388 KDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAEL----------KRLSEHLTESIL 437
K+E Q+K+ + +EK + + +Q +E + + ++ K++ E E +
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE--EETM 466
Query: 438 RGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALT 497
R + E+++ EW + +P + K E Q +Q Q EE I + ++ +
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE--QEKMQEQ---EEKIWEQEEKIR 521
Query: 498 AGEKAIAAERAM-KEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE---- 552
E+ E+ M ++ +EQE ++ EQ++ M QE+ + +MEKK +E+
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQE---DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Query: 553 --RENLLREHERLLKH--KLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
+E +RE ER+ + K++ +EEM++E+ +K EQ K Q ++ E + Q
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ 634
Score = 55.5 bits (132), Expect = 2e-07
Identities = 48/170 (28%), Positives = 94/170 (55%), Gaps = 25/170 (14%)
Query: 453 EKKQVEWDYKLVPRKGVKANEVLQNFLQSQV---VVEESILQSDKALTAGEKAIAAERAM 509
EK +++ + K + RK +A FL QV ++E + + ++ L EK I R
Sbjct: 240 EKSEIQLNVKELKRKLERAK-----FLLPQVQTNTLQEEMWRQEEELREQEKKI---RKQ 291
Query: 510 KEAAEKEQELLRE---KQKEQQQMMEAQERSFQEY---MAQMEKKLEEERENLLREHERL 563
+E +++E LRE K +EQ++ M QE+ +E + + EK+L E++E LRE E
Sbjct: 292 EEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE--LREQEEQ 349
Query: 564 L---KHKLKVQEEMLKEEFQK---KSEQLNKEINQLKEKIESTKNEQLRL 607
+ + K+ QEE ++E+ +K + E+L ++ Q++E+ + ++++ R+
Sbjct: 350 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 399
Score = 55.5 bits (132), Expect = 2e-07
Identities = 62/273 (22%), Positives = 126/273 (46%), Gaps = 22/273 (8%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
++M +Q + D +++ + ERE E + +++ + QK+ + E+++ ++
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 411 LQN--EEASAKYCQAELKRLSEHL--TESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPR 466
Q E+ + Q +++ E + E +R + G ++K E + ++ +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 467 KGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEK---EQELLR-- 521
+ K + Q + +E+ + +K E+ + E M+E +K E+E++R
Sbjct: 550 EE-KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Query: 522 -EKQKEQQQMMEAQERSF---QEYMAQMEKKLEE------ERENLLREHERLLKHKLKVQ 571
EK +EQ++ M+ QE +E M + E+K+ E E+E + E +RL + K K+
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 572 EEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
E +E +K EQ K Q EK+E EQ
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQ--EKMEKKTQEQ 699
Score = 53.1 bits (126), Expect = 8e-07
Identities = 61/267 (22%), Positives = 117/267 (43%), Gaps = 53/267 (19%)
Query: 375 EREAIAVFM------EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKY-------- 420
ER+A+++ + K +N E Q+KL E +K + L +E K
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKL-PLAESEKSEIQLNVKELKRKLERAKFLLP 263
Query: 421 ------CQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEV 474
Q E+ R E L E + + +E+K + +L ++G +
Sbjct: 264 QVQTNTLQEEMWRQEEELREQEKK----------IRKQEEKMWRQEERLREQEGKMREQE 313
Query: 475 LQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQEL------LREKQKEQQ 528
+ + Q E+ + + +K L EK + ++ ++E E+ QE EK +EQ+
Sbjct: 314 EKMWRQ-----EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE 368
Query: 529 QMMEAQERSFQEYMAQM---EKKLEEERENL------LREHERLLKHKLKVQEEMLKEEF 579
+ M QE E QM E+K+ ++ E + LRE E ++ + K+ E++ K
Sbjct: 369 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE 428
Query: 580 QKKSEQLNKEINQLKEKIESTKNEQLR 606
+KK ++ K+ +EK++ + E++R
Sbjct: 429 EKKMQEQEKKTRDQEEKMQ--EEERIR 453
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/225 (23%), Positives = 103/225 (45%), Gaps = 22/225 (9%)
Query: 384 EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSV 443
E + + E +KK D EK + + ++ E + + ++ E + E
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ-------- 615
Query: 444 PGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAI 503
+ +E+K E + K+ ++ + + + Q + + E+ L K + +
Sbjct: 616 --EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 504 AAERAMKEAAEK--EQELLREKQKEQQQMMEAQERSFQEY-MAQMEKKLEEERENLLREH 560
+ M+E EK EQE + +K +EQ++ QE+ +E M + EKK+ EE E ++RE
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE-MMREQ 732
Query: 561 ERLL---KHKLKVQEEMLKEEFQKKSEQLNK-----EINQLKEKI 597
E + + K++ QEE + E+ +K EQ K + + KEK+
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/168 (23%), Positives = 85/168 (50%), Gaps = 17/168 (10%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESIL--QSDKALTAGEKAIAAERAM 509
+EK+ E + +L +K ++ E + ++ +E + Q +K E+ E+ M
Sbjct: 326 QEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 510 KEAAEK----------EQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENL 556
+E +K + E LREK+ +EQ++M E E+ +E Q ++K ++E
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 557 LREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
++E ER+ + + K++EE +E +++ E++ K+ + E+ E +Q
Sbjct: 446 MQEEERIREREKKMREE--EETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Score = 49.7 bits (117), Expect = 8e-06
Identities = 36/154 (23%), Positives = 83/154 (53%), Gaps = 10/154 (6%)
Query: 451 LEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMK 510
++E+++ W+ + + +K + + + + Q ++ EES+ + +K K E M+
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEK--KTWDQEKMREEESMREREK------KMREEEEMMR 730
Query: 511 EAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLL-KHKLK 569
E EK QE + Q+++++M E +E+ +++ E++ E++ L EHE++ + K+
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIW 790
Query: 570 VQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNE 603
QEE ++++ +K Q K Q +EK+ + +
Sbjct: 791 EQEEKMRDQEEKMRGQEEKMRGQ-EEKMRGQEEK 823
Score = 46.2 bits (108), Expect = 9e-05
Identities = 40/169 (23%), Positives = 83/169 (49%), Gaps = 17/169 (10%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAER 507
+E+++ WD + R+ + E + + + ++ E Q +K EK E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 508 AMKEAAEK----EQELLREKQK--EQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561
M+E EK E+++ +++K EQQ++ E +E+ ++ Q ++K++E+ E + E E
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK-IWEQE 690
Query: 562 RLLK------HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
++ K K QE+M +EE ++ E+ +E ++ + E EQ
Sbjct: 691 KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Score = 46.2 bits (108), Expect = 9e-05
Identities = 52/262 (19%), Positives = 119/262 (45%), Gaps = 27/262 (10%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
++M +Q RLP + ++L + E+E + E ++ E E K EKK D
Sbjct: 652 EKMWEQQRLP-EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME---KKTQEQEKKTWDQE 707
Query: 411 LQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVK 470
EE S + + +++ E + E +E+K E + K+ ++
Sbjct: 708 KMREEESMREREKKMREEEEMMRE-----------------QEEKMQEQEEKMQEQEEEM 750
Query: 471 ANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQM 530
+ + + Q + + E+ L K + + + + E EK ++ EK + Q++
Sbjct: 751 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ-EEKMRGQEEK 809
Query: 531 MEAQE---RSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEM--LKEEFQKKSEQ 585
M QE R +E M E+K+ + E + + E++ + K++E+M +E+ +++ E+
Sbjct: 810 MRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEK 869
Query: 586 LNKEINQLKEKIESTKNEQLRL 607
+ + +++E+ E + ++ ++
Sbjct: 870 MRGQEEKMREQEEKMRGQEEKI 891
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/135 (28%), Positives = 71/135 (52%), Gaps = 13/135 (9%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQM 545
EE + + D+ L E+ + + M E EK +RE++K Q+Q + ++ QE Q
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEK----MREEKKMQEQEKKTRD---QEEKMQE 448
Query: 546 EKKLEEERENLLREHERLLK---HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKN 602
E+++ ERE +RE E ++ K++ QEE + E+ +K+ +Q + + + KEK+ +
Sbjct: 449 EERI-REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEK 505
Query: 603 EQLRLLKILDMASNI 617
Q + KI + I
Sbjct: 506 MQEQEEKIWEQEEKI 520
Score = 44.3 bits (103), Expect = 4e-04
Identities = 43/163 (26%), Positives = 84/163 (51%), Gaps = 13/163 (7%)
Query: 453 EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA 512
EKK E + K ++ E + ++ EE +++ + EK E M+E
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE-----EKMQEQEEKMQEQ 622
Query: 513 AEK--EQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLL-KHKLK 569
EK EQE ++Q+E +M E +E+ +++ E++ E++ L EHE++ + K++
Sbjct: 623 EEKMWEQEEKMQEQEE--KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 570 VQEEML--KEEFQKKS-EQLNKEINQLKEKIESTKNEQLRLLK 609
QEE + +E+ +KK+ EQ K +Q K + E + E+ + ++
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723
Score = 43.5 bits (101), Expect = 6e-04
Identities = 34/147 (23%), Positives = 71/147 (48%), Gaps = 14/147 (9%)
Query: 470 KANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQ 529
K + L L + E + + + L EK AE E +EL R+ ++ +
Sbjct: 204 KERDALSLELYRNTITNEELKKKNAELQ--EKLPLAESEKSEIQLNVKELKRKLERAKFL 261
Query: 530 MMEAQERSFQEYM-------AQMEKKLEEERENLLREHERLLKH--KLKVQEEML---KE 577
+ + Q + QE M + EKK+ ++ E + R+ ERL + K++ QEE + ++
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 578 EFQKKSEQLNKEINQLKEKIESTKNEQ 604
+++ ++L ++ +L+E+ E + E+
Sbjct: 322 RLREQEKELREQEKELREQKELREQEE 348
Score = 33.9 bits (76), Expect = 0.47
Identities = 25/122 (20%), Positives = 59/122 (48%), Gaps = 10/122 (8%)
Query: 496 LTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEEREN 555
LT A++ E +E + + +E+ + E+++ Q + ++++KLE +
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFL 261
Query: 556 LLREHERLLKHKLKVQEEMLKEEFQK----------KSEQLNKEINQLKEKIESTKNEQL 605
L + L+ ++ QEE L+E+ +K + E+L ++ +++E+ E ++
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 606 RL 607
RL
Sbjct: 322 RL 323
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/165 (31%), Positives = 91/165 (55%), Gaps = 16/165 (9%)
Query: 455 KQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERA-----M 509
++V + + + +KG K EV +N L +V E + Q ++ L EK +A E M
Sbjct: 1670 EKVAREEEKLAKKGGKLAEV-KNILAQKV---EELPQREQNLDWQEKELAQELEELEWDM 1725
Query: 510 KEAAEKEQELLREKQK--EQQQMMEAQERSF---QEYMAQMEKKLEEERENLLREHERLL 564
+E + KE+EL +E+ K E+++ + +E + +E +++ E KL +E E L++E E+L
Sbjct: 1726 EELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
Query: 565 KHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLK 609
+HK K+ EE +E +K EQL ++ +L +K E N L K
Sbjct: 1786 QHKEKMPEE--EERLGRKREQLIEKKMKLAQKRERWINSMEELTK 1828
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/228 (24%), Positives = 116/228 (50%), Gaps = 20/228 (8%)
Query: 405 KKGDFVLQNEEASAKYCQ--AELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYK 462
KK + V + EE AK AE+K + E + + ++ +E +++EWD +
Sbjct: 1667 KKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDME 1726
Query: 463 LVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLRE 522
+ K + N+ + ++V E+ L ++ A ++ +E K A++E+ L++E
Sbjct: 1727 ELSWKEEELNQE-----EGKLVEEKKKLAEEEEALAWQREKLSEEETK-LAQEEELLIQE 1780
Query: 523 KQK---EQQQMMEAQER--SFQEYMAQMEKKLEEERENLLREHERLLKHKLKV-QEEMLK 576
K+K +++M E +ER +E + + + KL ++RE + E L K+K+ + Q++ L
Sbjct: 1781 KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLA 1840
Query: 577 EE----FQKKSEQLNKEINQL--KEKIESTKNEQLRLLKILDMASNIM 618
+E Q+K + ++ N L KE++ +K + +++ L M + I+
Sbjct: 1841 QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKIL 1888
Score = 51.2 bits (121), Expect = 3e-06
Identities = 54/220 (24%), Positives = 118/220 (53%), Gaps = 27/220 (12%)
Query: 384 EHSFKDEN-HEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFS 442
E S+K+E ++ + KLV+ EKKK + + EEA A + ++LSE T+
Sbjct: 1727 ELSWKEEELNQEEGKLVE--EKKK---LAEEEEALAW----QREKLSEEETKLAQEEELL 1777
Query: 443 VPGGHNLYLEEKKQVEWDYKL------VPRKGVKANEVLQNFLQS--QVVVEESILQSDK 494
+ L ++K E + +L + K +K + + ++ S ++ + IL K
Sbjct: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK 1837
Query: 495 ALTAGEKAIAAERAMKEAAEKEQELLREKQK---EQQQMMEAQER--SFQEYMAQMEKKL 549
L +K +A E+ ++ A++++ LL K++ ++Q+++ + + F + +AQ+E+KL
Sbjct: 1838 NLAQEKKNLAQEK--EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKL 1895
Query: 550 EEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKE 589
+E+E ++++ E+L + + K+ + +++ KK E+L +E
Sbjct: 1896 TQEKETVIKKKEKLAETEKKLVQ--VEDSLAKKQEKLAQE 1933
Score = 50.4 bits (119), Expect = 5e-06
Identities = 29/122 (23%), Positives = 72/122 (59%), Gaps = 10/122 (8%)
Query: 490 LQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL 549
L+ ++L++ E E +E E+E+E +RE+++E+++ E +E+ ++ + +KK
Sbjct: 2237 LEKQESLSSEE-----EEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
Query: 550 EEERENLLREHERLLKHKLKVQ-----EEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
+E+++ ++E E + + K ++ E + EE +++S L +E+++ KE ++ K +
Sbjct: 2292 KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFK 2351
Query: 605 LR 606
L+
Sbjct: 2352 LQ 2353
Score = 43.9 bits (102), Expect = 5e-04
Identities = 34/141 (24%), Positives = 66/141 (46%), Gaps = 2/141 (1%)
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
G++ EV+ FL+ + + + DK + + + +E+ + LL E +K Q
Sbjct: 2183 GIEEEEVIP-FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEK-Q 2240
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ + +E +E + E+++ EE E E E K K +EE K++ +KK E++
Sbjct: 2241 ESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQ 2300
Query: 588 KEINQLKEKIESTKNEQLRLL 608
++ +EK E E+ L
Sbjct: 2301 EKEEVFEEKEEIMSEEETESL 2321
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/166 (24%), Positives = 77/166 (46%), Gaps = 28/166 (16%)
Query: 452 EEKKQVEWDYKL--VPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAA---- 505
EE++ ++ ++K + RK +A + + EE + Q ++ L E+ +A
Sbjct: 1563 EEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVK 1622
Query: 506 ----ERAMKEA----AEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLL 557
+R M +A A+KE+ L + +K Q+ E +AQ KKL ++ E +
Sbjct: 1623 ITQDDREMAQAEGKFAQKEETLAQRGEKLSQEA---------EKLAQKRKKLAKKWEKVA 1673
Query: 558 REHERLLKHKLKVQE-----EMLKEEFQKKSEQLNKEINQLKEKIE 598
RE E+L K K+ E EE ++ + L+ + +L +++E
Sbjct: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELE 1719
Score = 41.6 bits (96), Expect = 0.002
Identities = 68/305 (22%), Positives = 124/305 (40%), Gaps = 45/305 (14%)
Query: 343 QRAADHYSQQMAQQLRLPTDTLQELLD--VHAACEREAIAVFMEHSFKDENHEFQKKLVD 400
++ A H + ++ RL ++L++ + A +RE ME K++ +QKK
Sbjct: 1782 EKLAQHKEKMPEEEERLGRKR-EQLIEKKMKLAQKRERWINSMEELTKNKMILYQKK--- 1837
Query: 401 TIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD 460
+ ++K + + E+ + + + L E LT S + + V ++ + QVE
Sbjct: 1838 NLAQEKKNLAQEKEKLAQR--KENLLYNKERLTHS-KKQLVQVKNKLGMFNKILAQVEEK 1894
Query: 461 YKLVPRKGVKANEVLQNFLQSQVVVEESI-------------LQSDKALTAGEKAIAAE- 506
+K E L + V VE+S+ L +KA+ G+K + E
Sbjct: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954
Query: 507 ----------RAMKEAAEKEQELLREKQ----------KEQQQMMEAQERSFQEYMAQME 546
MK AE++ L+ K+ Q++M + ++ F+ ++ E
Sbjct: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
Query: 547 KKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR 606
K L E L E + K KL+ + F + +L K +L +K ES E +
Sbjct: 2015 KILLHEDRILAMEESEIAKGKLEFTRG--QRIFVQGQRKLAKASRKLIKKRESLSKEPAK 2072
Query: 607 LLKIL 611
L KIL
Sbjct: 2073 LNKIL 2077
Score = 40.4 bits (93), Expect = 0.005
Identities = 41/181 (22%), Positives = 80/181 (44%), Gaps = 29/181 (16%)
Query: 450 YLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAM 509
+ E++ ++ D K + RK K L N ++ + EE + + + L + +
Sbjct: 2125 FSEKRSELTKDEKKLARKQRK----LANKMRRMINKEEKMTEEESKLARKHSEVILDDEE 2180
Query: 510 KEAAEKEQELL----------------REKQKEQQQMMEAQ-ERSFQEYMAQMEKKLE-- 550
+ E+E+ + + K+K Q+ E + E F E M + +LE
Sbjct: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQ 2240
Query: 551 -----EERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQL 605
EE E E ER + +++ +EE KEE + + +Q+ KE + K+K + K E++
Sbjct: 2241 ESLSSEEEEEREEEEER-EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEV 2299
Query: 606 R 606
+
Sbjct: 2300 Q 2300
Score = 39.7 bits (91), Expect = 0.009
Identities = 53/218 (24%), Positives = 102/218 (46%), Gaps = 47/218 (21%)
Query: 410 VLQNEEASAKYCQAELKRLSEHLTESILRG----IFSVPGGHNLYLE-EKKQVEWDYKLV 464
V+ EE A+ ++ L E T+ IL+ IF PG + E KK+ + ++
Sbjct: 1342 VMPREEEQAQKKARDMLGLEE--TQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTFQKS 1399
Query: 465 PRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQ 524
P++G KA V E + + + +T E+ ++ E ++E A E+++++++
Sbjct: 1400 PKQGRKA-----------VQKERKVGKIKREMTKEERDMSEE--VEEMATLEEKVVKQEG 1446
Query: 525 K------------------EQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKH 566
K E +Q+ +S++ + + EK+L +E E L + E
Sbjct: 1447 KLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGE----- 1501
Query: 567 KLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
KL +EEML+E+ + K E E Q+ E + S+K+++
Sbjct: 1502 KLSPEEEMLQEDKKLKWE----EWKQVWENMLSSKSKE 1535
Score = 39.7 bits (91), Expect = 0.009
Identities = 36/138 (26%), Positives = 69/138 (50%), Gaps = 5/138 (3%)
Query: 479 LQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAE-KEQELLREKQ--KEQQQMMEAQE 535
L ++ +ES+ ++ E+ E +E E KE+E EKQ KE+++ + ++
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
Query: 536 RSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEE-MLKEEFQKKSEQLNKEIN-QL 593
+E + + E+ EE+ E + E L + + +E L+EE ++ E L KE +L
Sbjct: 2293 EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKL 2352
Query: 594 KEKIESTKNEQLRLLKIL 611
+E+ + + R+L IL
Sbjct: 2353 QEQRRKSLRGRERVLSIL 2370
Score = 38.5 bits (88), Expect = 0.019
Identities = 40/163 (24%), Positives = 68/163 (41%), Gaps = 40/163 (24%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQEL------------LREKQKEQQQMMEA 533
EE +LQ DK L E E M + KEQ+ RE ++++QQ+ E
Sbjct: 1506 EEEMLQEDKKLKWEEWKQVWEN-MLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEE 1564
Query: 534 QERSFQEY---------------MAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK-- 576
Q +E+ AQ E+KL +E E L +E +L + + K+ + +K
Sbjct: 1565 QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKIT 1624
Query: 577 ----------EEFQKKSEQLNKEINQLKEKIESTKNEQLRLLK 609
+F +K E L + +L ++ E ++ +L K
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK 1667
Score = 37.7 bits (86), Expect = 0.033
Identities = 34/140 (24%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 466 RKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQK 525
RK K + + SQV ++S++ + +++ E +E+ E+E +++
Sbjct: 2200 RKEAKRGDKPKEKFSSQV----DEVESEEHFSEEMESLLDELEKQESLSSEEE----EER 2251
Query: 526 EQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQ 585
E+++ E +E + + E++ +EE E ++ E+ + K K ++E KEE Q+K E
Sbjct: 2252 EEEEEREEEE------VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEV 2305
Query: 586 L-NKEINQLKEKIESTKNEQ 604
KE +E+ ES +E+
Sbjct: 2306 FEEKEEIMSEEETESLSDEE 2325
Score = 34.7 bits (78), Expect = 0.28
Identities = 24/103 (23%), Positives = 51/103 (49%), Gaps = 1/103 (0%)
Query: 506 ERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEEREN-LLREHERLL 564
E+ +E +K++E +E+ +E++++ E +E E + EEE E+ L E
Sbjct: 2281 EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE 2340
Query: 565 KHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
K LK +++ +E ++KS + + + + + K +RL
Sbjct: 2341 KEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRL 2383
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2457 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2504
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2198
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2199 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2257 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 611 LDM 613
L++
Sbjct: 2434 LEI 2436
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1957 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2070
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2191 LRLQLEETDHQK 2202
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2274
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2321
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2545 RQRLVASMEEARRRQ 2559
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1471
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1472 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1523
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1524 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1574
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1624
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1625 EEAERELERWQLKANEALRL 1644
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1621 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1662
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1663 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1692 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1738
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1919 QR-----RQVEEEILALKASFE 1935
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1408 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1938
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 1999 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2342 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2461 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2508
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2509 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2569 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2202
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2203 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2261 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2317
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 611 LDM 613
L++
Sbjct: 2438 LEI 2440
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1961 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2074
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2195 LRLQLEETDHQK 2206
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2278
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2325
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2488
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2549 RQRLVASMEEARRRQ 2563
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1461
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1475
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1476 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1527
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1528 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1578
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1628
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1629 EEAERELERWQLKANEALRL 1648
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1519 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1573
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1624
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1625 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1666
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1667 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1696 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1742
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1922
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1923 QR-----RQVEEEILALKASFE 1939
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1411
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1412 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1891
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1942
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 2003 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2457 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2504
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2505 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2198
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2199 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2257 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2313
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 611 LDM 613
L++
Sbjct: 2434 LEI 2436
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1957 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2070
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2191 LRLQLEETDHQK 2202
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2274
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2321
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2545 RQRLVASMEEARRRQ 2559
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1471
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1472 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1523
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1524 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1574
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1624
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1625 EEAERELERWQLKANEALRL 1644
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1621 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1662
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1663 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1692 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1738
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1919 QR-----RQVEEEILALKASFE 1935
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1408 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1938
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 1999 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2306 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2425 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2472
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2473 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2533 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2166
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2167 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2225 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2281
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 611 LDM 613
L++
Sbjct: 2402 LEI 2404
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1925 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2038
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2159 LRLQLEETDHQK 2170
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2242
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2289
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2452
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2513 RQRLVASMEEARRRQ 2527
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1425
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1439
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1440 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1491
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1492 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1542
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1592
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1593 EEAERELERWQLKANEALRL 1612
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1483 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1537
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1588
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1589 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1630
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1631 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1660 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1706
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1886
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1887 QR-----RQVEEEILALKASFE 1903
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1375
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1376 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1855
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1856 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1906
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 1967 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2475 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2594 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2641
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2642 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2702 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2335
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2336 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2394 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 611 LDM 613
L++
Sbjct: 2571 LEI 2573
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 2094 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2207
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2328 LRLQLEETDHQK 2339
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2411
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2458
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2682 RQRLVASMEEARRRQ 2696
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1594
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1608
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1609 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1660
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1661 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1711
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1761
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1762 EEAERELERWQLKANEALRL 1781
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1652 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1706
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1757
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1758 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1799
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1800 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1829 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1875
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 2056 QR-----RQVEEEILALKASFE 2072
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1544
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1545 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 2024
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 2025 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 2075
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 2136 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2316 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2435 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2482
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2483 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2543 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2176
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2177 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2235 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 611 LDM 613
L++
Sbjct: 2412 LEI 2414
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1935 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2048
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2169 LRLQLEETDHQK 2180
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2252
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2299
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2523 RQRLVASMEEARRRQ 2537
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1467
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1449
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1450 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1501
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1502 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1552
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1602
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1603 EEAERELERWQLKANEALRL 1622
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1493 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1598
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1599 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1640
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1641 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1670 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1716
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1897 QR-----RQVEEEILALKASFE 1913
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1385
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1386 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1865
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1866 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1916
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 1977 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2324 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2443 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2490
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2491 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2551 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2184
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2185 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2243 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2299
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 611 LDM 613
L++
Sbjct: 2420 LEI 2422
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1943 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2056
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2177 LRLQLEETDHQK 2188
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2260
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2307
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2470
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2531 RQRLVASMEEARRRQ 2545
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1443
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1475
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1457
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1458 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1509
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1510 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1560
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1610
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1611 EEAERELERWQLKANEALRL 1630
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1501 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1555
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1606
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1607 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1648
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1649 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1678 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1724
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1904
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1905 QR-----RQVEEEILALKASFE 1921
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1393
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1394 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1873
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1874 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1924
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1984
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 1985 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/274 (23%), Positives = 125/274 (45%), Gaps = 33/274 (12%)
Query: 333 LAQLENPAAVQRAADHYSQQMAQQLRLPTDTL----QELLDVHAACEREAIAVF----ME 384
LAQ E +Q + +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2365 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 385 HSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+++ F+K+ + EK + E+ + ++ S+H E + I +
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
EK++++ + KL+ K +E +Q Q Q++ E LQ L+ + +
Sbjct: 2484 -------REKEKLQQEAKLLQLK----SEEMQTVQQEQLLQETQALQQS-FLSEKDSLLQ 2531
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY----------MAQMEKKLEEERE 554
ER +++ K ++L +++ + QQ+ E Q+R Q+ M + ++ E E
Sbjct: 2532 RERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Query: 555 NLLREHERL--LKHKLKVQEEMLKEEFQKKSEQL 586
+ R+ E L L+ + + QEE+L EE Q+ EQL
Sbjct: 2592 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Score = 47.8 bits (112), Expect = 3e-05
Identities = 60/303 (19%), Positives = 121/303 (39%), Gaps = 25/303 (8%)
Query: 327 ENAVTALAQLENPAAVQRAA-----DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
E AQ E A Q+ A + + + Q LR QEL + E
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET---- 2225
Query: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
+H + E Q+ + E + ++ E S + EL +L + I
Sbjct: 2226 --DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQ----SDKALT 497
+L+E+ + K V + + + Q + + + EE + Q ++K L
Sbjct: 2284 RDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 498 AGEKAIAAERAMKEAAE---KEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERE 554
+A+ +K AE +++EL +E+ + Q+ E + E ++ LE ER+
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 555 NLLREHERLLKHKLKVQE-EMLKEEFQKKSEQLNKEINQLKEKIESTK---NEQLRLLKI 610
L + KL+V E + ++ +++ K+ ++ EK+ T+ E++ L++
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 611 LDM 613
L++
Sbjct: 2461 LEI 2463
Score = 46.6 bits (109), Expect = 7e-05
Identities = 55/252 (21%), Positives = 113/252 (44%), Gaps = 15/252 (5%)
Query: 362 DTLQ--ELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAK 419
DTL+ E ++ AA +R+ +A E ++ QK L E + E K
Sbjct: 1984 DTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042
Query: 420 YCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E +RL E + R + L+ +++ + ++ K E+ Q
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA---HAFAVQQ--KEQELQQTLQ 2097
Query: 480 QSQVVVEESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLREKQKEQQQMMEAQERSF 538
Q Q V+++ +++ A A E+A A +A +EAA+ +++ ++ +Q +AQ R+
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Query: 539 QEYMAQ-MEKKLEEERENLLREHERLLKHKLKVQEEMLK-----EEFQKKSEQLNKEINQ 592
+ A+ + K+ E+E + + L+ K EM K E+ ++ Q+ +E+
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2217
Query: 593 LKEKIESTKNEQ 604
L+ ++E T +++
Sbjct: 2218 LRLQLEETDHQK 2229
Score = 44.3 bits (103), Expect = 4e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 40/297 (13%)
Query: 329 AVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAI-AVFMEHSF 387
A + Q+E ++++A+ +Q AQ + + L++ + AA +A A +
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 388 KDENHEFQKKLVDTIEKKKGD---------FVLQNEEASAKYCQAELKRLSEHLTES--- 435
D E KK + ++K L+ + EL+RL TE+
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 436 ---ILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQS 492
+ +FSV + K ++E + + + ++ + Q FLQ EE+
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQ-----EEAEKMK 2301
Query: 493 DKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE 552
A A ++AA+ A + E++L AQ+R+ E M + + + +E
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDL-------------AQQRALAEKMLKEKMQAVQE 2348
Query: 553 RENLLREHERLLKHKLKVQEE--MLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
L E E L + K QE+ L+E+ ++ ++QL +E + +E+ + QL +
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Score = 43.5 bits (101), Expect = 6e-04
Identities = 57/315 (18%), Positives = 129/315 (40%), Gaps = 42/315 (13%)
Query: 332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREA-IAVFMEHSFKDE 390
A + EN A + R D+ + + ++ +E + A + A + E +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 391 NHEFQKKLVDTIE--------KKKGDFVLQNEEAS---AKYCQAELKRLSEHLTESILRG 439
+K L + ++ K + + + Q +E + A+ Q + +++++ L E
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391
Query: 440 IFSVPGGHNLYLE---EKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKAL 496
++ LE E ++++ + R +A E Q F + + E + +++ A
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
Query: 497 TAGEKAIAAERAMKEAAEKEQELLRE--------KQKEQQQMMEAQERSFQEYMAQMEKK 548
+ ++ ++ + E LRE K+K QQ+ Q +S + Q E+
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
Query: 549 LEEER---ENLLREHERLLKHKLKVQEE----------------MLKEEFQKKSEQLNKE 589
L+E + ++ L E + LL+ + +++E L+EE Q++ +Q+ +E
Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571
Query: 590 INQLKEKIESTKNEQ 604
+L +E + Q
Sbjct: 2572 RQRLVASMEEARRRQ 2586
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/152 (21%), Positives = 72/152 (47%), Gaps = 19/152 (12%)
Query: 472 NEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEA-AEKEQELLREKQKEQQQM 530
+E L+ + + + E+ + + L E A+ +R + EA A+ + + RE ++ QQ+M
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 531 MEA-------------QERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKE 577
E Q+RS QE + Q+ + E E + R+ E + +L+++EE+
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
Query: 578 EFQKKSEQLNK-----EINQLKEKIESTKNEQ 604
Q ++ + + E+ L+ + E + ++
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQK 1516
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/260 (23%), Positives = 115/260 (44%), Gaps = 37/260 (14%)
Query: 351 QQMAQQLRLPTDT-LQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKG-- 407
Q+ QQLR ++ +Q A ER + + +E + ++ E+++G
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRGGA 1498
Query: 408 DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
+ LQ A A+ +A+ KR ++ E + R + + K+Q E + +
Sbjct: 1499 EGELQALRARAEEAEAQ-KRQAQEEAERLRRQVQDES-------QRKRQAEVELASRVKA 1550
Query: 468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
+A Q LQ+ +EE LQ+++A E+ + +A E A + Q L Q+
Sbjct: 1551 EAEAAREKQRALQA---LEELRLQAEEA----ERRL--RQAEVERARQVQVALETAQRSA 1601
Query: 528 QQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLN 587
+ ++++ SF E AQ+E+ L+EE + + E E + + Q ++E+
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE----------EAERRAQQQAEAERAR 1651
Query: 588 KEINQLKEKIESTKNEQLRL 607
+E + E+ + NE LRL
Sbjct: 1652 EEAERELERWQLKANEALRL 1671
Score = 38.5 bits (88), Expect = 0.019
Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 58/287 (20%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEH 385
+E A A+ E QRA Q ++LRL + + L + V +E
Sbjct: 1542 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
Query: 386 SFKDENHEFQKKLVDTIEKKKG-DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVP 444
+ + E Q K EK + LQ E + + E +R ++ E+
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1647
Query: 445 GGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
E+ + E + +L R +KANE L+ LQ++ V ++ L +A
Sbjct: 1648 --------ERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEA--------- 1689
Query: 505 AERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKL-EEERENLLREHERL 563
EKQKE+ + EA+ R E A +++L E+E E + E
Sbjct: 1690 -----------------EKQKEEAE-REARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 564 LKHKLKVQEEMLK-----EEFQKKSEQLNKEINQL-KEKIESTKNEQ 604
+ +L ++E+++ E+ +++ + L +E+ +L +E +T+ Q
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Score = 35.4 bits (80), Expect = 0.16
Identities = 54/262 (20%), Positives = 112/262 (42%), Gaps = 32/262 (12%)
Query: 351 QQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFV 410
Q++ +Q +L T Q+ L A E+E I + E E E Q++L++ +
Sbjct: 1719 QELEKQRQLAEGTAQQRL----AAEQELIRLRAE----TEQGEQQRQLLEEELAR----- 1765
Query: 411 LQNEEASA----KYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWD---YKL 463
LQ E A+A + +AEL ++ + + + + + K+++E + ++
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825
Query: 464 VPRKGVKANEVLQNFLQSQVVVEESIL----QSDKALTAGEKAIAAERAMKEAAE---KE 516
+ + + + + + + + EE ++++ L AI +K AE KE
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885
Query: 517 QELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK 576
+E E+ + + Q R +E AQ + +EE L + + L+ + + E+ L+
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1945
Query: 577 EEFQKKSEQLNKEINQLKEKIE 598
+ Q+ +EI LK E
Sbjct: 1946 QR-----RQVEEEILALKASFE 1962
Score = 32.7 bits (73), Expect = 1.1
Identities = 22/105 (20%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 506 ERAMKEAAEKEQELLREKQ---KEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHER 562
ER ++ +E+E L E + ++Q+Q+ EA ++ + + ++ + +E ++R E
Sbjct: 1375 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1434
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + Q+ ++EE Q+ + EI + E+ + +LR+
Sbjct: 1435 AVD--AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Score = 32.7 bits (73), Expect = 1.1
Identities = 72/295 (24%), Positives = 126/295 (42%), Gaps = 44/295 (14%)
Query: 336 LENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQ 395
L + A + + S++ Q+L +EL + A A + +E+ Q
Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 396 KKLVDTIEKKK----GDFVLQNEEA--SAKYCQAELKRLSEHLTESIL--RGIFSVPGGH 447
+ + + +K G+ EA + K +AE +RL + R + H
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1914
Query: 448 NLYLEEKK---QVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIA 504
+EE+ + D +L +KG+ +++ L+ + VEE IL AL A + A
Sbjct: 1915 KADIEERLAQLRKASDSELERQKGL-----VEDTLRQRRQVEEEIL----ALKASFEKAA 1965
Query: 505 AERAMKEAA-----EKEQELLREKQK------EQQQMMEAQERSFQEYMAQMEKKL--EE 551
A +A E ++ LR K++ Q+Q+ +ER +E +++K L EE
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025
Query: 552 E----RENLLREHERLLKHKLKVQE-EMLKEEFQKKSE---QLNKEINQLKEKIE 598
E R+ L E ERL K KV+E L+E +++S QL +E Q + + E
Sbjct: 2026 EAARQRKAALEEVERL---KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 58.2 bits (139), Expect = 2e-08
Identities = 49/180 (27%), Positives = 91/180 (50%), Gaps = 30/180 (16%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKE 511
E++K+ E + K+ R+ K E + + + +++E Q +K EK E M+E
Sbjct: 374 EQEKRQEQEAKMW-RQEEKIREQEEKIREQEEMMQE---QEEKMGEQEEKMWEQEEEMQE 429
Query: 512 AAEK---EQELLREKQK----------EQQQMMEAQERSFQEY---MAQMEKKLEEEREN 555
EK ++E +RE++K EQ++MM+ QE E M + E K++E+ E
Sbjct: 430 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489
Query: 556 LLREHERL---------LKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR 606
+ R+ E++ + K++ QEEM++E+ +K EQ K Q +EK++ + + R
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-EEKMQEQEEKMRR 548
Score = 57.4 bits (137), Expect = 4e-08
Identities = 64/262 (24%), Positives = 122/262 (46%), Gaps = 21/262 (8%)
Query: 375 EREAIAVFM------EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRL 428
ER+A+++ + + K++N + Q+KL +E +K + L +E K +A+L
Sbjct: 189 ERDALSLELYRNTITDEELKEKNAKLQEKL-QLVESEKSEIQLNVKELKRKLERAKLLLP 247
Query: 429 SEHL---TESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVV 485
+ L + + + + SV +EE + + K + E +Q +
Sbjct: 248 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ 307
Query: 486 EESILQSDKALTAGEKAI--------AAERAMKEAAEKEQELLREKQKEQQQMMEAQE-R 536
EE I + ++ + E+ + E M E EK +EL EK EQ+++ E +E R
Sbjct: 308 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL-EEKMHEQEKIREQEEKR 366
Query: 537 SFQEYMAQMEKKLEEERENLLREHE-RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKE 595
+E + + EK+ E+E + +E + R + K++ QEEM++E+ +K EQ K Q +E
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 596 KIESTKNEQLRLLKILDMASNI 617
E + + + KI + I
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKI 448
Score = 57.0 bits (136), Expect = 5e-08
Identities = 59/275 (21%), Positives = 129/275 (46%), Gaps = 43/275 (15%)
Query: 356 QLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDE------NHEFQKKLVDTIEK-KKGD 408
+L LP LQ D H E ++++ ++ ++ N + ++K+ EK ++ +
Sbjct: 243 KLLLPQQQLQAEAD-HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQERE 301
Query: 409 FVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKG 468
+Q +E + + +++R E + E + + ++++ W+ K
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEEMMWEKEEK------------MRRQEEMMWE------KE 343
Query: 469 VKANEVLQNFLQSQVVVE-ESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQ 527
K E+ + + + + E E Q ++ + EK E M EK +E EK +EQ
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ-EEKIREQ 402
Query: 528 QQMMEAQERSF---QEYMAQMEKKLEEERENLLREHERLLKHKLKV---------QEEML 575
++MM+ QE +E M + E++++E+ E + R+ E++ + + K+ QEEM+
Sbjct: 403 EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 462
Query: 576 KEEFQKKSEQLNKEINQ---LKEKIESTKNEQLRL 607
+E+ +K EQ K Q ++E+ E + ++ ++
Sbjct: 463 QEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKI 497
Score = 55.8 bits (133), Expect = 1e-07
Identities = 72/305 (23%), Positives = 149/305 (48%), Gaps = 37/305 (12%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQ-------LRLPTDTLQELLDVHAACEREA 378
LE A++A+A ++ AD Y +++ ++ L T T +EL + +A + +
Sbjct: 165 LEQALSAVA------TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 218
Query: 379 IAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLT----E 434
V E K E K+L +E+ K Q +A A + EL+ +S L E
Sbjct: 219 QLVESE---KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Query: 435 SILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDK 494
+ L + ++ +E+K E + K+ ++ K E + + + ++ E + +K
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE-KIREQEEKMRRQEEMMWE---KEEK 331
Query: 495 ALTAGEKAIAAERAMKEAAEK--EQELLRE---KQKEQQQMMEAQERSFQEY-MAQMEKK 548
E E ++E EK EQE +RE K++E++++ E ++R QE M + E+K
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 549 LEEERENLLREHERLL---KHKLKVQEEML---KEEFQKKSEQLNKEINQLKEKIESTKN 602
+ E+ E +RE E ++ + K+ QEE + +EE Q++ E++ ++ +++E+ + +
Sbjct: 392 IREQEEK-IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIRE 450
Query: 603 EQLRL 607
++ ++
Sbjct: 451 QEEKI 455
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/225 (20%), Positives = 110/225 (48%), Gaps = 19/225 (8%)
Query: 388 KDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGH 447
+++ HE Q+K+ + EK++ + ++ +E + +A++ R E + E
Sbjct: 350 EEKMHE-QEKIREQEEKRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQ----------EE 397
Query: 448 NLYLEEKKQVEWDYKLVPR--KGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAA 505
+ +E+ E + K+ + K + E +Q + EE I + +K + E+ I
Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457
Query: 506 ERAMKEAAEKEQELLREKQKEQQQMMEAQE---RSFQEYMAQMEKKLEEERENLLREHER 562
+ M + E++ K EQ+ M+ QE R +E + + EKK+ E+ E + + E
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517
Query: 563 LLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRL 607
+ + + K+ E+ +E+ ++ E++ ++ +++ + E + +++RL
Sbjct: 518 MQEQEEKMWEQ--EEKMCEQEEKMQEQEEKMRRQEEKMREQEVRL 560
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/119 (27%), Positives = 63/119 (52%), Gaps = 21/119 (17%)
Query: 480 QSQVVVEESILQSDKALTAGE---KAIAAERAMKEAAEK---EQELLREKQK-------- 525
Q + + E+ + ++ GE K E M+E EK ++E +RE++K
Sbjct: 451 QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Query: 526 --EQQQMMEAQERSF---QEYMAQMEKKLEEERENLLREHERLLKH--KLKVQEEMLKE 577
EQ++MM+ QE +E M + E+K++E+ E + R+ E++ + +L+ QEE ++E
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/116 (21%), Positives = 67/116 (57%), Gaps = 5/116 (4%)
Query: 486 EESILQSDKALTAGEKAIAAERAM---KEAAEKEQELLREKQKEQQQMMEAQERSFQEYM 542
EE I + ++ + E+ + + +EA +EQE +Q+E+ + E + R +E +
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Query: 543 AQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIE 598
+ E+ ++E+ E + + E++ + + K+QE+ +E+ +++ E++ ++ +L+++ E
Sbjct: 512 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ--EEKMRRQEEKMREQEVRLRQQEE 565
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/145 (20%), Positives = 74/145 (51%), Gaps = 8/145 (5%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVV---EESILQSDKALTAGEKAIAAERA 508
E++++++ + + R+ K E + + + + EE + + ++ + E + + A
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 509 MKEAAEKEQELLREKQKEQQQMMEAQE---RSFQEYMAQMEKKLEEERENLLREHERLLK 565
+ E++ EK +EQ++ + QE R +E M + E+K+ E+ E + + E++ +
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 566 H--KLKVQEEMLKEEFQKKSEQLNK 588
K++ QEE ++E+ + +Q K
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/81 (28%), Positives = 43/81 (53%), Gaps = 4/81 (4%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQM 545
EE I + +K + E+ I + M + E++ EK EQ++ M+ QE E M +
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE----EKMRRQ 549
Query: 546 EKKLEEERENLLREHERLLKH 566
E+K+ E+ L ++ E++ +H
Sbjct: 550 EEKMREQEVRLRQQEEKMQEH 570
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/215 (20%), Positives = 95/215 (44%), Gaps = 30/215 (13%)
Query: 375 EREAIAVFMEHSFKDENHEF--QKKLVDTIEKKKGDFV--LQNEEASAKYCQAELKRLSE 430
E+EA E +++ + Q++++ E+K G+ + +E + + +++R E
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 431 HLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESIL 490
+ E +EKK E + K+ ++ E++Q + E +
Sbjct: 440 KIRE-----------------QEKKIREQEEKIREQE-----EMMQEQEEKMGEQEGKMC 477
Query: 491 QSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLE 550
+ + + E+ + + EK+ EK +EQ++MM+ QE E Q EK E
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE---QEEKMCE 534
Query: 551 EERENLLREHE-RLLKHKLKVQEEMLKEEFQKKSE 584
+E + +E + R + K++ QE L+++ +K E
Sbjct: 535 QEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/315 (22%), Positives = 153/315 (48%), Gaps = 45/315 (14%)
Query: 326 LENAVTALAQLENPAAVQRAADHYSQQMAQQ-------LRLPTDTLQELLDVHAACEREA 378
LE A++A+A ++ AD Y +++ ++ L T T +EL + +A + +
Sbjct: 238 LEQALSAVA------TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 291
Query: 379 IAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLT----E 434
V E K E K+L +E+ K Q +A A + EL+ +S L E
Sbjct: 292 QLVESE---KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 348
Query: 435 SILRGIFSVPGGHNLYLEEKKQVEWDYKL------VPRKGVKANEVLQNFLQSQVVV--- 485
+ L + ++ +E+K EW+ K+ + + K E + + + ++
Sbjct: 349 NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK 408
Query: 486 -------EESILQSDKALTAGEKAI-AAERAMKEAAEK--EQELLRE---KQKEQQQMME 532
EE + + ++ + E+ + E ++E EK EQE +RE K++E++++ E
Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 468
Query: 533 AQERSFQEY-MAQMEKKLEEERENLLREHERLLKHKLKV--QEEMLKEEFQKKSEQLNKE 589
++R QE M + E+K+ E+ E + + E++ + + K+ QE++ +EE +++ E++ ++
Sbjct: 469 QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 528
Query: 590 INQLKEKIESTKNEQ 604
+++E+ E + ++
Sbjct: 529 EEKIREQEEIWRQKE 543
Score = 56.2 bits (134), Expect = 9e-08
Identities = 38/128 (29%), Positives = 68/128 (53%), Gaps = 14/128 (10%)
Query: 491 QSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSF---QEYMAQMEK 547
Q +K EK E ++E EK +E EK +EQ++M + QE +E M + E+
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQ-EEKIREQEEMTQEQEEKMGEQEEKMCEQEE 627
Query: 548 KLEEERENLLREHERL---------LKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIE 598
K++E+ E + R+ E++ + K++ QEEM++E+ +K EQ K Q +EK++
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-EEKMQ 686
Query: 599 STKNEQLR 606
+ + R
Sbjct: 687 EQEEKMRR 694
Score = 54.7 bits (130), Expect = 3e-07
Identities = 52/248 (20%), Positives = 119/248 (47%), Gaps = 23/248 (9%)
Query: 375 EREAIAVFM------EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRL 428
ER+A+++ + + K++N + Q+KL +E +K + L +E K +A+L
Sbjct: 262 ERDALSLELYRNTITDEELKEKNAKLQEKL-QLVESEKSEIQLNVKELKRKLERAKLLLP 320
Query: 429 SEHL---TESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVV 485
+ L + + + + SV +EE + + K + E +Q + +
Sbjct: 321 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ 380
Query: 486 EESILQSDKALTAGEKAIAAERAM----KEAAEKEQELL---REKQKEQQQMMEAQERSF 538
EE I + ++ + E+ + + M +E +++E++ EK + Q++MM +E
Sbjct: 381 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 440
Query: 539 QEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIE 598
+E +E+K+ E+ + +RE E + + K++E+ ++E + K + ++I + +EKI
Sbjct: 441 RE----LEEKMHEQEK--IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 494
Query: 599 STKNEQLR 606
+ + R
Sbjct: 495 EQEEKMWR 502
Score = 53.1 bits (126), Expect = 8e-07
Identities = 66/316 (20%), Positives = 138/316 (43%), Gaps = 39/316 (12%)
Query: 318 INSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACERE 377
IN+G P T +P Q+A+ + + + ++L T++ L C++
Sbjct: 151 INNGTNP----ETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRIL-----TCQKT 201
Query: 378 AIAV---FMEHSFKD---ENHEFQKKLVDT---------------IEKKKGDFVLQNEEA 416
+ + + +H+ K E + +L D+ +KKK D ++
Sbjct: 202 ELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTK 261
Query: 417 SAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQ 476
EL R + E + + L EK +++ + K + RK +A +L
Sbjct: 262 ERDALSLELYR-NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 320
Query: 477 NFLQSQVVVEESILQSD-KALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQE 535
Q Q+ E L + ++++A +A E + ++QE +Q+E+ Q E +
Sbjct: 321 ---QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI 377
Query: 536 RSFQEYMAQMEKKLEEERENLLREHERLLK--HKLKVQEEML--KEEFQKKSEQLNKEIN 591
+ +E + + E+K+ E+ E + R+ E + + K++ QEEM+ KEE ++ E++ E
Sbjct: 378 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 437
Query: 592 QLKEKIESTKNEQLRL 607
+ ++E +EQ ++
Sbjct: 438 EKIRELEEKMHEQEKI 453
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/155 (23%), Positives = 80/155 (51%), Gaps = 21/155 (13%)
Query: 452 EEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKE 511
E++++V + + + K E + + + + +E Q +K EK E M+E
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE---QEEKMGEQEEKMCEQEEKMQE 631
Query: 512 AAEK---EQELLREKQK----------EQQQMMEAQERSF---QEYMAQMEKKLEEEREN 555
EK ++E +RE++K EQ++MM+ QE +E M + E+K++E+ E
Sbjct: 632 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691
Query: 556 LLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEI 590
+ R+ E++ + +++++++ +E+ Q+ E L I
Sbjct: 692 MRRQEEKMWEQEVRLRQQ--EEKMQEHQEHLEAAI 724
Score = 50.8 bits (120), Expect = 4e-06
Identities = 29/125 (23%), Positives = 68/125 (54%), Gaps = 5/125 (4%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQE---RSFQEYM 542
EE I + ++ + E+ I + M + E++ EK EQ++ M+ QE R +E +
Sbjct: 584 EEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643
Query: 543 AQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKN 602
+ EKK+ E+ E + + E + + + K+ E+ +E+ ++ E++ ++ +++ + E
Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQ--EEKMCEQEEKMQEQEEKMRRQEEKMWE 701
Query: 603 EQLRL 607
+++RL
Sbjct: 702 QEVRL 706
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/136 (27%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 486 EESILQSDKALTAGEKAIAAERAMKEAAEKEQE-LLREKQK--EQQQMMEAQERSF---Q 539
EE I + +K ++ E +E +EQE + R+K+K EQ++ + QE +
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Query: 540 EYMAQMEKKLEEERENLLREHERLLKH---------KLKVQEEMLKEEFQKKSEQLNKEI 590
E M E+K+ E+ E + R+ E++ + K++ QEEM +E+ +K EQ K
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 623
Query: 591 NQLKEKIESTKNEQLR 606
Q +EK++ + + R
Sbjct: 624 EQ-EEKMQEQEEKMRR 638
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/128 (25%), Positives = 70/128 (54%), Gaps = 10/128 (7%)
Query: 486 EESILQSDKALTAGEKAIAAE-RAMKEAAEKEQELLRE-----KQKEQQQMMEAQERSFQ 539
EE + + ++ + EK E R +E +++E +RE +QKE+ E + R +
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 540 EYMAQMEKKLEEERENLLREHERLLK--HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKI 597
E M + E+K+ ++ E + + E++ + K++ QEE ++E+ +K EQ +E+ Q +E+
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQ--EEMTQEQEEK 614
Query: 598 ESTKNEQL 605
+ E++
Sbjct: 615 MGEQEEKM 622
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/223 (17%), Positives = 111/223 (49%), Gaps = 18/223 (8%)
Query: 388 KDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGH 447
+++ E+++K+ + EK ++ +E + + +++R E + E + +
Sbjct: 367 EEKIQEWEEKIQEQEEK------IREQEEKIREQEEKMRRQEEMMWEKEEK----MRRQE 416
Query: 448 NLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVE-ESILQSDKALTAGEKAIAAE 506
+ E+++++ +++ K K E+ + + + + E E Q ++ + EK E
Sbjct: 417 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 476
Query: 507 RAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEE-----RENLLREHE 561
M EK +E + ++++++M +E+ ++ + E+K +E+ +E +RE E
Sbjct: 477 AKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 536
Query: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQ 604
+ + K K+ E+ +E+ +K+ E++ ++ ++ ++ E + ++
Sbjct: 537 EIWRQKEKIHEQ--EEKIRKQEEKMWRQEEKMHDQEEKIREQE 577
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 58.2 bits (139), Expect = 2e-08
Identities = 55/257 (21%), Positives = 118/257 (45%), Gaps = 36/257 (14%)
Query: 365 QELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQA- 423
Q+L+D + C++ + + + N Q + + +++K+ +LQNE+ +A
Sbjct: 15 QKLVDENY-CKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
Query: 424 ----ELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFL 479
E KRL E L L++++++ + + + +K ++ Q
Sbjct: 74 QKAEENKRLKE------------------LQLKQEEKLAMELAKLKHESLKDEKMRQQVR 115
Query: 480 QSQVVVEE-------SILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQ---KEQQQ 529
++ + + E + + ++A EK MK AE + ++ E + KE+
Sbjct: 116 ENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENA 175
Query: 530 MMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLK--EEFQKKSEQLN 587
+ + ++ +Y +EK+LEE+ + +E+LLK KL + E + K EE Q + +Q
Sbjct: 176 AEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
Query: 588 KEINQLKEKIESTKNEQ 604
+++N ++ IE + EQ
Sbjct: 236 EKMNAMRRYIEEFQKEQ 252
Score = 40.8 bits (94), Expect = 0.004
Identities = 58/234 (24%), Positives = 108/234 (46%), Gaps = 42/234 (17%)
Query: 388 KDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRL------SEHLTESILRGIF 441
++E E +K+++ ++ + E+ AK + E KRL ++ L E + +
Sbjct: 260 REEMEEENRKIIEFANMQQQ----REEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRED 315
Query: 442 SVPGGHNLYLEEKKQVEWDYKL---VPRKGVKANEVLQNFLQSQVVVEESILQSDK---- 494
LY EE+ ++ + KL +K K E+ Q+F + Q+ ++E +LQ+ K
Sbjct: 316 LEQVRQELYQEEQAEI-YKSKLKEEAEKKLRKQKEMKQDF-EEQMALKELVLQAAKEEEE 373
Query: 495 -------ALTAGEKAIAAERAMKEAAEK-EQELLREK--QKEQQQMMEAQERSFQEYMAQ 544
A A + I A K+ ++ E EK ++ +QQ + ++R +E+ Q
Sbjct: 374 NFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQ 433
Query: 545 MEKK------LEEERENLLREHER-----LLKHKLKVQE--EMLKEEFQKKSEQ 585
++ +EEER LL+EH L K K ++ ++L EEF+K +Q
Sbjct: 434 QRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQ 487
Score = 39.7 bits (91), Expect = 0.009
Identities = 55/260 (21%), Positives = 116/260 (44%), Gaps = 33/260 (12%)
Query: 355 QQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNE 414
+Q++ + + +++ H +E E++ +D+ ++ + + +EK Q E
Sbjct: 150 EQMKRDAEIAKTMMEEHKRIIKE------ENAAEDKRNKAKAQYYLDLEK-------QLE 196
Query: 415 EASAKYCQAELKRLSEHLT-ESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANE 473
E K +A + L E L + I+R I+ E+ Q+E KL ++
Sbjct: 197 EQEKKKQEAYEQLLKEKLMIDEIVRKIY-----------EEDQLEKQQKLEKMNAMR--R 243
Query: 474 VLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEA 533
++ F + Q + + + ++ K I ++ E ++E ++++ Q+ A
Sbjct: 244 YIEEFQKEQALWRKK--KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNA 301
Query: 534 QERSFQEYMAQMEKKLEEERENLLREHE-RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQ 592
+ +E + Q E LE+ R+ L +E + + K KLK + E K QK+ +Q +E
Sbjct: 302 LTQKLEEMLRQRED-LEQVRQELYQEEQAEIYKSKLKEEAEK-KLRKQKEMKQDFEEQMA 359
Query: 593 LKEKI-ESTKNEQLRLLKIL 611
LKE + ++ K E+ K +
Sbjct: 360 LKELVLQAAKEEEENFRKTM 379
Score = 33.9 bits (76), Expect = 0.47
Identities = 41/164 (25%), Positives = 77/164 (46%), Gaps = 13/164 (7%)
Query: 448 NLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKA----LTAGEKAI 503
NL E+ Q D + V+A + + + +++Q+V E+ + + L E+
Sbjct: 7 NLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQF- 65
Query: 504 AAERAMKEAAEKEQE--LLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENL--LRE 559
E M+EA +K +E L+E Q +Q++ + + + + EK ++ REN LRE
Sbjct: 66 --ELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRE 123
Query: 560 HERLLK--HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTK 601
E+ LK + K + + E+ K EQ+ ++ K +E K
Sbjct: 124 LEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHK 167
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 57.8 bits (138), Expect = 3e-08
Identities = 67/303 (22%), Positives = 134/303 (44%), Gaps = 62/303 (20%)
Query: 375 EREAIAVFM------EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAEL--- 425
ER+A+++ + + K++N E Q+KL +E +K + L ++ K +A+L
Sbjct: 198 ERDALSLELYRNTITDEELKEKNAELQEKL-RLVESEKSEIQLNVKDLKRKLERAQLLLP 256
Query: 426 -------------------KRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPR 466
+L + E+ L + + ++ +E+K E + K+ +
Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ 316
Query: 467 KGVKANEVLQNFLQSQVVV---EESIL-QSDKALTAGEKAIAAERAMKEAAEK------- 515
+ +K E + + + + EE I Q DK EK E ++E EK
Sbjct: 317 E-LKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEK 375
Query: 516 ---EQELLREKQKE---QQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLK 569
+ E ++E+++E Q++ + QE QE M + EKK+ E+ E + + E + + + K
Sbjct: 376 IREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEK 435
Query: 570 V---------QEEMLKE------EFQKKSEQLNKEINQLKEKIESTKNEQLRLLKILDMA 614
+ QEE L+E E ++K ++ ++I + +EKI+ + + R K+L
Sbjct: 436 IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Query: 615 SNI 617
I
Sbjct: 496 EKI 498
Score = 51.6 bits (122), Expect = 2e-06
Identities = 68/273 (24%), Positives = 123/273 (45%), Gaps = 33/273 (12%)
Query: 356 QLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEE 415
QL LP LQ D +E +V + + E +E L E+K + +E
Sbjct: 252 QLLLPQQQLQVEAD---RLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 416 ASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVL 475
K C+ ELK + E + R ++ +E+K E + K+ R+ K E
Sbjct: 309 QEEKMCEQELKIREQE--EKMWRQ------EEKMHEQEEKIREQEDKMW-RQEEKIREQE 359
Query: 476 QNFLQSQVVV---EESILQSDKALTAGEKAI-AAERAMKEAAEKEQELL----------R 521
+ + + + EE I + D+ + E+ + E ++E EK QE +
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 522 EKQKEQQQMMEAQE---RSFQEYMAQMEKKLEEERENLLREHERLLKHKLKV--QEEMLK 576
EK +EQ++ M QE R +E M E+KL E E + E E++ + + K+ QEE ++
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 577 EEFQK--KSEQLNKEINQLKEKIESTKNEQLRL 607
E+ +K + E+L K+ ++ E+ E ++ ++
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Score = 50.1 bits (118), Expect = 6e-06
Identities = 51/285 (17%), Positives = 138/285 (48%), Gaps = 43/285 (15%)
Query: 350 SQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSF---KDENHEFQKKLVDTIEKK- 405
+QQ +++ + +QE CE+E E +++ HE ++K+ + +K
Sbjct: 292 NQQQEEKMWRQEEKIQE--QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMW 349
Query: 406 KGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEW-DYKLV 464
+ + ++ +E + + ++ R E + E + ++E+++ W + +
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEK------------IQEQEEEMWRQEEKI 397
Query: 465 PRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREK- 523
+ K E + + +E I + ++ + E+ I R ++E + ++E LRE
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKI---RELEEMMQDQEEKLREVE 454
Query: 524 -----------------QKEQQQMMEAQERSF-QEYMAQMEKKLEEERENLLREHERLLK 565
Q++++++ E +E+++ QE + + E+K+ E+ E + R+ E++ +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 566 HKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLKI 610
+ K+QE+ +E+ Q++ E++ ++ +L ++ E + +++RL ++
Sbjct: 515 QEEKMQEQ--EEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/166 (25%), Positives = 89/166 (53%), Gaps = 20/166 (12%)
Query: 449 LYLEEKKQVEWDYKLVPR---------KGVKANEVLQNFLQSQVVVEESILQSDKALTAG 499
++ +EKK E D K+ + K + E++Q+ + VEE + + ++ +
Sbjct: 408 MWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467
Query: 500 EKAIAA-ERAMKEAAEK---EQELLREKQK--EQQQMMEAQERSFQEYMAQMEKKLEEER 553
E+ I E ++E EK +++LL++++K EQ++ M QE E Q EK E+E
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE---QEEKMQEQE- 523
Query: 554 ENLLREHERLLKHKLKV-QEEMLKEEFQKKSEQLNKEINQLKEKIE 598
E + R+ E++ + ++++ Q+E +E + + ++L + + +L +K E
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Score = 32.0 bits (71), Expect = 1.8
Identities = 35/175 (20%), Positives = 80/175 (45%), Gaps = 9/175 (5%)
Query: 384 EHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSV 443
E +++ + Q+K+ +K + E+ + Q E R E + + + V
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 444 PGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESIL--QSDKALTAGEK 501
+ EE+K E + K+ ++ + + + Q +++ +E + Q +K EK
Sbjct: 454 E--EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENL 556
E M+E +E+++ R+++K ++Q + ++ +E M + E +L+E E L
Sbjct: 512 MWEQEEKMQE---QEEKMQRQEEKMREQEVRLWQQ--EEKMQEQEVRLQELEERL 561
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,195,012
Number of Sequences: 37866
Number of extensions: 1060515
Number of successful extensions: 18457
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 465
Number of HSP's successfully gapped in prelim test: 1112
Number of HSP's that attempted gapping in prelim test: 6937
Number of HSP's gapped (non-prelim): 6610
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.