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Search of human proteins with 31317305
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317305 M-phase phosphoprotein 10 [Homo sapiens]
(681 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317305 M-phase phosphoprotein 10 [Homo sapiens] 1335 0.0
gi|169210281 PREDICTED: similar to M-phase phosphoprotein 10 (U3... 241 1e-63
gi|169210051 PREDICTED: similar to M-phase phosphoprotein 10 (U3... 241 1e-63
gi|169210488 PREDICTED: similar to M-phase phosphoprotein 10 (U3... 238 1e-62
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 177 3e-44
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 176 5e-44
gi|87299628 biorientation of chromosomes in cell division 1-like... 79 1e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 73 8e-13
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 73 8e-13
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 73 8e-13
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 73 8e-13
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 73 8e-13
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 73 8e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 71 3e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 68 3e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 67 4e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 5e-11
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 67 5e-11
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 67 7e-11
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 67 7e-11
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 67 7e-11
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 66 9e-11
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 66 9e-11
gi|148746195 trichohyalin [Homo sapiens] 65 3e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 6e-10
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 63 1e-09
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 62 2e-09
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 62 2e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 61 3e-09
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 61 4e-09
>gi|31317305 M-phase phosphoprotein 10 [Homo sapiens]
Length = 681
Score = 1335 bits (3455), Expect = 0.0
Identities = 681/681 (100%), Positives = 681/681 (100%)
Query: 1 MAPQVWRRRTLERCLTEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHG 60
MAPQVWRRRTLERCLTEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHG
Sbjct: 1 MAPQVWRRRTLERCLTEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHG 60
Query: 61 SPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGS 120
SPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGS
Sbjct: 61 SPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGS 120
Query: 121 EIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKL 180
EIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKL
Sbjct: 121 EIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKL 180
Query: 181 EQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDI 240
EQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDI
Sbjct: 181 EQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDI 240
Query: 241 DSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEE 300
DSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEE
Sbjct: 241 DSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEE 300
Query: 301 AEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSF 360
AEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSF
Sbjct: 301 AEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSF 360
Query: 361 EKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEE 420
EKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEE
Sbjct: 361 EKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEE 420
Query: 421 TTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKL 480
TTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKL
Sbjct: 421 TTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKL 480
Query: 481 NQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAP 540
NQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAP
Sbjct: 481 NQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAP 540
Query: 541 VSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLE 600
VSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLE
Sbjct: 541 VSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLE 600
Query: 601 KSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQIND 660
KSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQIND
Sbjct: 601 KSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQIND 660
Query: 661 AKKTEKKKKKRQDISVHKLKL 681
AKKTEKKKKKRQDISVHKLKL
Sbjct: 661 AKKTEKKKKKRQDISVHKLKL 681
>gi|169210281 PREDICTED: similar to M-phase phosphoprotein 10 (U3
small nucleolar ribonucleoprotein) [Homo sapiens]
Length = 213
Score = 241 bits (616), Expect = 1e-63
Identities = 131/201 (65%), Positives = 149/201 (74%), Gaps = 27/201 (13%)
Query: 104 ISLLPESEEQEREEDGSEIEADDKEDLEDL-EEEEVSDMGNDDPEMGERAENSSKSDLRK 162
+ L ESEEQE EEDGSE E +EDLEDL EEEEVSDMG D+PE+G++A NSSK +LRK
Sbjct: 25 VELGEESEEQECEEDGSETETGGQEDLEDLQEEEEVSDMGGDNPEVGKKARNSSKFELRK 84
Query: 163 SPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEE 222
SPVFSDEDSDLDFDISKLEQQSKVQN G GKPREKSI+D+KFF+LSEMEAYLEN EKEEE
Sbjct: 85 SPVFSDEDSDLDFDISKLEQQSKVQNTGHGKPREKSIIDEKFFQLSEMEAYLENREKEEE 144
Query: 223 RKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNV 282
RKDDND+E SGKSSRN+ KDFFDPVESDEDI +
Sbjct: 145 RKDDNDDE--------------------------SGKSSRNVNNKDFFDPVESDEDIASD 178
Query: 283 HDDELDSNKEDDEIAEEEAEE 303
HDDEL SNK + +++ +E
Sbjct: 179 HDDELGSNKMMKLLKKKQKKE 199
>gi|169210051 PREDICTED: similar to M-phase phosphoprotein 10 (U3
small nucleolar ribonucleoprotein) [Homo sapiens]
Length = 213
Score = 241 bits (616), Expect = 1e-63
Identities = 131/201 (65%), Positives = 149/201 (74%), Gaps = 27/201 (13%)
Query: 104 ISLLPESEEQEREEDGSEIEADDKEDLEDL-EEEEVSDMGNDDPEMGERAENSSKSDLRK 162
+ L ESEEQE EEDGSE E +EDLEDL EEEEVSDMG D+PE+G++A NSSK +LRK
Sbjct: 25 VELGEESEEQECEEDGSETETGGQEDLEDLQEEEEVSDMGGDNPEVGKKARNSSKFELRK 84
Query: 163 SPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEE 222
SPVFSDEDSDLDFDISKLEQQSKVQN G GKPREKSI+D+KFF+LSEMEAYLEN EKEEE
Sbjct: 85 SPVFSDEDSDLDFDISKLEQQSKVQNTGHGKPREKSIIDEKFFQLSEMEAYLENREKEEE 144
Query: 223 RKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNV 282
RKDDND+E SGKSSRN+ KDFFDPVESDEDI +
Sbjct: 145 RKDDNDDE--------------------------SGKSSRNVNNKDFFDPVESDEDIASD 178
Query: 283 HDDELDSNKEDDEIAEEEAEE 303
HDDEL SNK + +++ +E
Sbjct: 179 HDDELGSNKMMKLLKKKQKKE 199
>gi|169210488 PREDICTED: similar to M-phase phosphoprotein 10 (U3
small nucleolar ribonucleoprotein) [Homo sapiens]
Length = 213
Score = 238 bits (607), Expect = 1e-62
Identities = 130/201 (64%), Positives = 148/201 (73%), Gaps = 27/201 (13%)
Query: 104 ISLLPESEEQEREEDGSEIEADDKEDLEDL-EEEEVSDMGNDDPEMGERAENSSKSDLRK 162
+ L ESEEQE EEDGSE E +EDLEDL EEEEVSDMG D+PE+G++A NSSK +LRK
Sbjct: 25 VELGEESEEQECEEDGSETETGGQEDLEDLQEEEEVSDMGGDNPEVGKKARNSSKFELRK 84
Query: 163 SPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEE 222
SPVFSDEDSDLDFDISKLEQQSKVQN G GKPREKSI+D+KFF+LSEMEAYLEN EKEEE
Sbjct: 85 SPVFSDEDSDLDFDISKLEQQSKVQNTGHGKPREKSIIDEKFFQLSEMEAYLENREKEEE 144
Query: 223 RKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNV 282
RKDDND+E S KSSRN+ KDFFDPVESDEDI +
Sbjct: 145 RKDDNDDE--------------------------SVKSSRNVNNKDFFDPVESDEDIASD 178
Query: 283 HDDELDSNKEDDEIAEEEAEE 303
HDDEL SNK + +++ +E
Sbjct: 179 HDDELGSNKMMKLLKKKQKKE 199
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 177 bits (449), Expect = 3e-44
Identities = 144/469 (30%), Positives = 234/469 (49%), Gaps = 54/469 (11%)
Query: 251 GSKKLKSGKSSRNLKYKDFFDPVESDEDIT-NVHDDELDSNKE----------DDEIAEE 299
G + + + + K+ PV SDED + H ++L+ + + IA+E
Sbjct: 2 GGDNPEVSERANSSKFDPTKSPVLSDEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADE 61
Query: 300 EAEELSISET-------------DEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGV 346
+ +LS E DEDDDL+E+ED+KQ KESLKRVTF LPDD ED GV
Sbjct: 62 KFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGV 121
Query: 347 LNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLH 406
+VKKNSDEVKSSF+KRQEKMNEK + K ++ KKPW GEVTAQKRPENSLLEETLH
Sbjct: 122 SHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLH 181
Query: 407 FDHAVRMAPVITEETTLQLEDIIKQR--IRDQAWDDVVRKEKPKEDAYEYKKRLTL-DHE 463
FDHAVRM I E + K+R + + + + + E+ KE E +++L L + E
Sbjct: 182 FDHAVRMGTYI--------EKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESE 233
Query: 464 KSKL-----SLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFI-- 516
KS++ L E+ + L QQ+ E + E+Q + L +++ ++ +
Sbjct: 234 KSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQ 293
Query: 517 ----------PKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTA 566
K E K+ I +E + E+I+E+ +
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE 353
Query: 567 AEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKY--SKTVASEKLKQLTK 624
+ +K RE+ +K +++ KI+E++++ + E+ Q K + EK+ + K
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413
Query: 625 TGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQD 673
+ K +++ + + +L++ ++ Q ++ E+K ++ ++
Sbjct: 414 KMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEE 462
Score = 50.1 bits (118), Expect = 7e-06
Identities = 79/421 (18%), Positives = 185/421 (43%), Gaps = 67/421 (15%)
Query: 98 TINDEDISLLPESEEQER----EEDGSEIEADDKEDLEDLEEEEV----SDMGNDDPEMG 149
TI DE++ +E QE+ E + SEI+ + K+ LE ++ + + +G
Sbjct: 210 TITDEELKE-KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLG 268
Query: 150 ERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSE 209
+ E S S ++ V E+++L +++ +Q+ K+ R++ + ++ K+ E
Sbjct: 269 K--ELQSVSAKLQAQV---EENEL-WNLLNQQQEEKMW-------RQEEKIQEQEEKMCE 315
Query: 210 MEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDF 269
E + E++ R+++ E+E E I ED K + ++ ++
Sbjct: 316 QELKIREQEEKMWRQEEKMHEQE-----EKIREQED----------KMWRQEEKIREQE- 359
Query: 270 FDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK 329
+ + E+ ++++ +E DE +E+ EE+ +++ ++E E+ +Q K +
Sbjct: 360 -EKIREQEEKMWRQEEKI---REQDEKIQEQEEEM----WRQEEKIREQEEKRQEKMWRQ 411
Query: 330 RVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGE 389
D+ E + +E E+ + EK+ +E+++ E++ ++Q +
Sbjct: 412 EKKMREQDEKIREQEEEM---WRQEEKIRELEEMMQDQEEKLREVEEKMQEEEE-KMQEQ 467
Query: 390 VTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKE 449
+R E + E+ EE T + E ++KQ ++ W+ + + +E
Sbjct: 468 EEKIQRQEEKIQEQ---------------EEKTWRQEKLLKQE--EKIWEQEEKMWRQEE 510
Query: 450 DAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDA 509
+E ++++ EK + ++ EQE Q++ +E+ E+++ + L K +
Sbjct: 511 KMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAEL 570
Query: 510 L 510
L
Sbjct: 571 L 571
Score = 47.4 bits (111), Expect = 4e-05
Identities = 55/257 (21%), Positives = 115/257 (44%), Gaps = 25/257 (9%)
Query: 73 DEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDK--EDL 130
+E++W+Q E +E + + +E I E EE+ RE++ ++K E
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR---EQEEKIREQEEKMWRQEEKIREQD 380
Query: 131 EDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKG 190
E ++E+E +M + ++ E+ E + R+ ++D K+ +Q + +
Sbjct: 381 EKIQEQE-EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE-------KIREQEEEMWRQ 432
Query: 191 QGKPRE-KSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGL 249
+ K RE + ++ D+ KL E+E EK +E ++ E+EE I E+ +++E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVE------EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Query: 250 FGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISET 309
K LK + K + + + E+ ++++ +E + EE+ E +
Sbjct: 487 RQEKLLKQEE-----KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW 541
Query: 310 DEDDDLQENEDNKQHKE 326
+++ +QE E Q E
Sbjct: 542 QQEEKMQEQEVRLQELE 558
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 176 bits (447), Expect = 5e-44
Identities = 144/469 (30%), Positives = 233/469 (49%), Gaps = 54/469 (11%)
Query: 251 GSKKLKSGKSSRNLKYKDFFDPVESDEDIT-NVHDDELDSNKE----------DDEIAEE 299
G + + + + K+ PV SDED + H ++L+ + + IA+E
Sbjct: 2 GGDNPEVSERANSSKFDPTKSPVLSDEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADE 61
Query: 300 EAEELSISET-------------DEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGV 346
+ +LS E DEDDDL+E+ED+KQ KESLKRVTF LPDD ED GV
Sbjct: 62 KFFQLSEMEAYLENRKRRGTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGV 121
Query: 347 LNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLH 406
+VKKNSDEVKSSF+KRQEKMNEK + K ++ KKPW GEVTAQKRPENSLLEETLH
Sbjct: 122 SHVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLH 181
Query: 407 FDHAVRMAPVITEETTLQLEDIIKQRIRD--QAWDDVVRKEKPKEDAYEYKKRLTL-DHE 463
FDHAVRM I E + K+R + + + + E+ KE E +++L L + E
Sbjct: 182 FDHAVRMGTYI--------EKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESE 233
Query: 464 KSKL-----SLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFI-- 516
KS++ L E+ + L QQ+ E + E+Q + L +++ ++ +
Sbjct: 234 KSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQ 293
Query: 517 ----------PKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTA 566
K E K+ I +E + E+I+E+ +
Sbjct: 294 QQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE 353
Query: 567 AEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKY--SKTVASEKLKQLTK 624
+ +K RE+ +K +++ KI+E++++ + E+ Q K + EK+ + K
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413
Query: 625 TGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQD 673
+ K +++ + + +L++ ++ Q ++ E+K ++ ++
Sbjct: 414 KMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEE 462
Score = 52.4 bits (124), Expect = 1e-06
Identities = 82/436 (18%), Positives = 193/436 (44%), Gaps = 71/436 (16%)
Query: 83 QNEPILQYFQNAVSETINDEDISLLPESEEQER----EEDGSEIEADDKEDLEDLEEEEV 138
++ P L+ ++N TI DE++ +E QE+ E + SEI+ + K+ LE ++
Sbjct: 199 RDAPSLELYRN----TITDEELKE-KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQL 253
Query: 139 ----SDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKP 194
+ + +G+ E S S ++ V E+++L +++ +Q+ K+
Sbjct: 254 LLPQQQLQVEADRLGK--ELQSVSAKLQAQV---EENEL-WNLLNQQQEEKMW------- 300
Query: 195 REKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKK 254
R++ + ++ K+ E E + E++ R+++ E+E E I ED
Sbjct: 301 RQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE-----EKIREQED--------- 346
Query: 255 LKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDD 314
K + ++ ++ + + E+ ++++ +E DE +E+ EE+ +++
Sbjct: 347 -KMWRQEEKIREQE--EKIREQEEKMWRQEEKI---REQDEKIQEQEEEM----WRQEEK 396
Query: 315 LQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASL 374
++E E+ +Q K + D+ E + +E E+ + EK+ +
Sbjct: 397 IREQEEKRQEKMWRQEKKMREQDEKIREQEEEM---WRQEEKIRELEEMMQDQEEKLREV 453
Query: 375 EKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIR 434
E+++ E++ ++Q + +R E + E+ EE T + E ++KQ
Sbjct: 454 EEKMQEEEE-KMQEQEEKIQRQEEKIQEQ---------------EEKTWRQEKLLKQE-- 495
Query: 435 DQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHV 494
++ W+ + + +E +E ++++ EK + ++ EQE Q++ +E+
Sbjct: 496 EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQ 555
Query: 495 EIQKMMDSLFLKLDAL 510
E+++ + L K + L
Sbjct: 556 ELEERLGKLGQKAELL 571
Score = 47.4 bits (111), Expect = 4e-05
Identities = 55/257 (21%), Positives = 115/257 (44%), Gaps = 25/257 (9%)
Query: 73 DEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDK--EDL 130
+E++W+Q E +E + + +E I E EE+ RE++ ++K E
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR---EQEEKIREQEEKMWRQEEKIREQD 380
Query: 131 EDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKG 190
E ++E+E +M + ++ E+ E + R+ ++D K+ +Q + +
Sbjct: 381 EKIQEQE-EEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE-------KIREQEEEMWRQ 432
Query: 191 QGKPRE-KSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGL 249
+ K RE + ++ D+ KL E+E EK +E ++ E+EE I E+ +++E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVE------EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTW 486
Query: 250 FGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISET 309
K LK + K + + + E+ ++++ +E + EE+ E +
Sbjct: 487 RQEKLLKQEE-----KIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW 541
Query: 310 DEDDDLQENEDNKQHKE 326
+++ +QE E Q E
Sbjct: 542 QQEEKMQEQEVRLQELE 558
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 79.0 bits (193), Expect = 1e-14
Identities = 135/627 (21%), Positives = 264/627 (42%), Gaps = 97/627 (15%)
Query: 94 AVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAE 153
A +ET N + + + D S + ED+ D +E+ +D G + E ++E
Sbjct: 220 ASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMAD-KEKSTADSGGEGLETAPKSE 278
Query: 154 NSSKSDLRKSPV--FSDEDSDL-----DFDISKLEQQSKVQNKGQGKPREKSIVDDKFFK 206
S + ++ E ++L D EQ++K +KG+ KP + K K
Sbjct: 279 EFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEK 338
Query: 207 LSEMEAYLENIEKEEER---KDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRN 263
+ E ++ +K E+ KD+ +E++++ S KL S K+S
Sbjct: 339 KEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE----------------SLKLPSEKNSNK 382
Query: 264 LK----YKDFFDPVESDED------ITNVHDDELDSNKEDDEIAEEEAEELSISETDEDD 313
K K+ F ++SD D +++VH +L S +ED E EE+ S++ E+
Sbjct: 383 AKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTE------EEVVTSDSMEEG 436
Query: 314 DLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSF------EKRQEKM 367
++ +++ K + K T D +E + V + + + S + E E+
Sbjct: 437 EITSDDEEKNKQNKTKTQT---SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQR 493
Query: 368 NEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLED 427
+ IA ++E L ++ Q+ E +KR + + ++ R + + E +T LE
Sbjct: 494 RQSIAKEKEERLLRR--QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEP 551
Query: 428 IIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAE 487
RI+ +V+++ K E K++ L ++ K S + E K ++ ++
Sbjct: 552 -KAARIK-----EVLKERKVLE------KKVALSKKRKKDS-RNVEENSKKKQQYEEDSK 598
Query: 488 E--ENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAI-------TMEEV 538
E + EH E +K+ S LK + H +P P ++ +L + +E
Sbjct: 599 ETLKTSEHCEKEKISSSKELK-----HVHAKSEPSKPARRLSESLHVVDENKNESKLERE 653
Query: 539 APVSVSDAALLAPEEIKEKNKAGDIKTAAEKT---ATDKKRERRKKKYQKRMKIKEKE-- 593
S ++ E ++E+ D+K E++ + ++++ K +K +K + E
Sbjct: 654 HKRRTSTPVIM--EGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETP 711
Query: 594 KRRKLLEK--SSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQ 651
+ LL+K S + + KT + +KL K K + G + L SS+ K++
Sbjct: 712 HLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKY-KGDCMHKTGDETELHSSEKGL-KVE 769
Query: 652 DQVKMQINDAK-----KTEKKKKKRQD 673
+ ++ Q K KTE+K K R +
Sbjct: 770 ENIQKQSQQTKLSSDDKTERKSKHRNE 796
Score = 50.8 bits (120), Expect = 4e-06
Identities = 57/266 (21%), Positives = 111/266 (41%), Gaps = 18/266 (6%)
Query: 89 QYFQNAVSETINDEDI--SLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDP 146
Q++ ++ E ++ D+ S + ++ Q E + + + ++ DLE+L +
Sbjct: 2775 QHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSR 2834
Query: 147 EMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDD-KFF 205
M E+ E SS + P E +D D S+ E Q + + +G+PR+ + K
Sbjct: 2835 VMEEKDEYSSSETTGEKP----EQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMK 2890
Query: 206 KLSEMEAYLENIEKEEE-------RKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSG 258
S+ + + +E+ + D++++E ++ I +D+ E + S + +
Sbjct: 2891 DDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQ-ERSISNDDGEEKIVTSVRRRGR 2949
Query: 259 KSSRNLKYKDFFDPVESDEDITNVHDDELDSNKE---DDEIAEEEAEELSISETDEDDDL 315
K R+L D + E + D ++ KE D+E EEE +E S + T
Sbjct: 2950 KPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRS 3009
Query: 316 QENEDNKQHKESLKRVTFALPDDAET 341
+ Q S+KR P A T
Sbjct: 3010 EAQRSKTQLSPSIKRKREVSPPGART 3035
Score = 49.3 bits (116), Expect = 1e-05
Identities = 133/669 (19%), Positives = 252/669 (37%), Gaps = 121/669 (18%)
Query: 99 INDEDISLLPESEEQEREEDGSE--IEADDKEDLE-DLEEEEVSDMGNDDPEMGERAENS 155
+ D +S + S+ EED E + +D E+ E ++EE + + + +E
Sbjct: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
Query: 156 SKSDLRK--------SPVFSDEDSDL--------------------DFDISKLEQQSKVQ 187
+KS S +SD D +L + KLE++ K +
Sbjct: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
Query: 188 --------NKGQGKP----REKSI--VDDKFFKLSEMEAYLENIEKE----EERKDDNDE 229
KGQG+ E S ++ K ++ E+ + +EK+ ++RK D+
Sbjct: 523 AEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRN 582
Query: 230 EEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDD--EL 287
EE+ + + D E L S+ + K S + + K E + + + +
Sbjct: 583 VEENSKKKQQYEEDSKET-LKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVV 641
Query: 288 DSNKEDDEIAEEEAEELSI--------SETDEDDDLQE-------NEDNKQHKESLKRVT 332
D NK + ++ E S ETD D ++ E+ ++ K +LK
Sbjct: 642 DENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEK 701
Query: 333 FALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTA 392
DD+ET L K EVKSS EK + EK S +K ++ K +G+
Sbjct: 702 HLKKDDSETPHLKSLLKK----EVKSSKEKPER---EKTPSEDKLSVKHK---YKGDCMH 751
Query: 393 QKRPENSL--LEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQ-------------- 436
+ E L E+ L + ++ +++T L +D +++ + +
Sbjct: 752 KTGDETELHSSEKGLKVEENIQKQ---SQQTKLSSDDKTERKSKHRNERKLSVLGKDGKP 808
Query: 437 ------AWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEEN 490
D+ VRKE K++ ++ +H+ + S ++I + T + +
Sbjct: 809 VSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRS 868
Query: 491 PEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLA 550
+ E + MDS +N KP K ++ E++ S S
Sbjct: 869 ESYSEDKCDMDS--------TNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQ 920
Query: 551 PEEIKEKNKAGDIKTA-AEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGK 609
+ ++ + + G K A K +K E + Q++ K+++K E++ V+ +
Sbjct: 921 VKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKP-----FEETGVEPVLE 975
Query: 610 YSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQD-----QVKMQINDAKKT 664
+ + A K + K K++ K +S KL D +K D KK
Sbjct: 976 TASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKK 1035
Query: 665 EKKKKKRQD 673
++ K +D
Sbjct: 1036 DENKSDDKD 1044
Score = 47.0 bits (110), Expect = 6e-05
Identities = 68/306 (22%), Positives = 117/306 (38%), Gaps = 32/306 (10%)
Query: 81 ELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSD 140
ELQ EP+L V+E++N E+ E + EI + K++ E + V
Sbjct: 2703 ELQREPLL------VNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEA 2756
Query: 141 MGNDDPEMGERAENSSKSDLRKSPVFSDEDSD------LDFDISKLEQQSKVQNKGQGKP 194
DP+ E E RK S ED LD I ++Q K
Sbjct: 2757 ----DPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
Query: 195 REKSIVDDKFFKLSEMEAYLENI--EKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGS 252
+++ SE + + EK+E + E+ + + + I S E++ +
Sbjct: 2813 ENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIK 2872
Query: 253 KKLKSGKS---SRNLKYKDFFDPVESDEDITNVHDDELDSN---KEDDEIAEEEA--EEL 304
+K + LK KD ++D I V S + DE +E A +E
Sbjct: 2873 RKRGRPRKYPVETTLKMKD---DSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQER 2929
Query: 305 SISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQ 364
SIS D ++ + + + K + + + DDAE+ + K SD V+ E+
Sbjct: 2930 SISNDDGEEKIVTSVRRRGRKP---KRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQES 2986
Query: 365 EKMNEK 370
++ E+
Sbjct: 2987 DEEEEE 2992
Score = 35.0 bits (79), Expect = 0.23
Identities = 38/148 (25%), Positives = 57/148 (38%), Gaps = 7/148 (4%)
Query: 183 QSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFF-EDID 241
+ K + + + KS V+DK F+ + +E LE + + E
Sbjct: 943 KEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYK 1002
Query: 242 SDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEA 301
SD+D +KL G SR+LK+ D + DE N DD+ KE D E+
Sbjct: 1003 SDKDSTSTRLERKLSDGHKSRSLKHSS-KDIKKKDE---NKSDDK--DGKEVDSSHEKAR 1056
Query: 302 EELSISETDEDDDLQENEDNKQHKESLK 329
S+ E L EN +E K
Sbjct: 1057 GNSSLMEKKLSRRLCENRRGSLSQEMAK 1084
Score = 34.3 bits (77), Expect = 0.39
Identities = 53/238 (22%), Positives = 98/238 (41%), Gaps = 27/238 (11%)
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
K + K D+ E +R EK++ + E + QK +E+ + E++ SL
Sbjct: 321 KGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSE----DTQKVKDEKQAKEKEVE----SL 372
Query: 504 FLKLDALSNFHFIPKPPVPEIKVV-SNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGD 562
L + SN + + ++ S++ +T V+ V SD + E+ +E+ D
Sbjct: 373 KLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE-EDTEEEVVTSD 431
Query: 563 IKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQL 622
E T+ D+++ ++ K K E + K + + V + YSK S+ +L
Sbjct: 432 SMEEGEITSDDEEKNKQNKT--KTQTSDSSEGKTKSVRHAYVHKPYLYSKYY-SDSDDEL 488
Query: 623 TKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLK 680
T + I E +++ L+ QIN K EK+K+K + K K
Sbjct: 489 TVEQRRQSIAKEKEERLLRR--------------QINREKLEEKRKQKAEKTKSSKTK 532
Score = 33.5 bits (75), Expect = 0.67
Identities = 45/252 (17%), Positives = 110/252 (43%), Gaps = 24/252 (9%)
Query: 95 VSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAEN 154
VSE I D ++ E+ ++ER + +A+ K + + +G+ + + +
Sbjct: 809 VSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRS 868
Query: 155 SSKSDLRKSPVFSDEDSDLDFDI----------SKLEQQSKVQNKGQGKPREKSIVDDKF 204
S S+ + ++ DS+L + S LE++ +++K + + ++ +V+ +
Sbjct: 869 ESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETEL 928
Query: 205 FKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNL 264
+ + +A +KE+ + +ND E++ E D +E G+ L++ SS +
Sbjct: 929 QEGATKQATTPKPDKEKNTE-ENDSEKQRKSKVE--DKPFEETGV--EPVLETASSSAHS 983
Query: 265 KYKDFF---------DPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDL 315
KD + +SD+D T+ + S+ + ++++ + ++ DD
Sbjct: 984 TQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDK 1043
Query: 316 QENEDNKQHKES 327
E + H+++
Sbjct: 1044 DGKEVDSSHEKA 1055
Score = 31.2 bits (69), Expect = 3.3
Identities = 24/103 (23%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 96 SETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENS 155
S T++D+ S PE + Q+ D E + + + D E+ EEEE D+P G ++
Sbjct: 2954 SLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEE------DEPS-GATTRST 3006
Query: 156 SKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKS 198
++S+ ++S ++S +++ Q + + P +K+
Sbjct: 3007 TRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKA 3049
Score = 30.8 bits (68), Expect = 4.3
Identities = 62/284 (21%), Positives = 112/284 (39%), Gaps = 32/284 (11%)
Query: 135 EEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKG---- 190
EE V D+GN++ + K++L+ E+ ++ E + G
Sbjct: 2645 EENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAEL 2704
Query: 191 QGKP---REKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEG 247
Q +P E V++ F+ +E E + E+ K E D E + D E E
Sbjct: 2705 QREPLLVNESLNVENSGFRTNE-EIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVE- 2762
Query: 248 GLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSIS 307
++ K R Y S ED + + D LDS E A+ + E
Sbjct: 2763 ----EEERHMPKRKRKQHYL-------SSEDEPDDNPDVLDSRIET---AQRQCPETEPH 2808
Query: 308 ETDEDD--DLQE-NEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEK-- 362
+T E++ DL+E + + + + RV + + +E TG + + D +KS E
Sbjct: 2809 DTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQP 2868
Query: 363 ---RQEKMNEKIASLEKELLEKKPWQLQ-GEVTAQKRPENSLLE 402
++++ + +E L K + G VT ++ P +S L+
Sbjct: 2869 IIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLK 2912
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 347 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 406
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 407 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 466
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 467 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 523
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 524 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 582
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 583 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 642
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 643 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 695
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 696 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 755
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 756 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 815
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 816 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 862
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 863 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 921
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 395 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 449
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 450 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 509
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 510 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 566
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 567 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 626
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 627 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 675
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 676 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 735
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 736 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 789
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 790 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 849
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 850 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 909
Score = 43.1 bits (100), Expect = 8e-04
Identities = 117/582 (20%), Positives = 214/582 (36%), Gaps = 127/582 (21%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D + +Q SK+ ++ G P+++
Sbjct: 217 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR 276
Query: 198 --------------------------SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEE 231
S + FF +A + +I + ++R D+
Sbjct: 277 KAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTT-- 334
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFD------PVESDEDIT--NVH 283
D DI S+ D+ L L++ +S L K+ D P E++ D++ + H
Sbjct: 335 -GADSLLDISSEADQQDLLSL--LQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYH 391
Query: 284 DDELDSNKEDDEIAEEEAEE-----------LSISETDEDDDLQENEDNKQ------HKE 326
+ D + E + L S TD D +Q+ ++ Q
Sbjct: 392 STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESS 451
Query: 327 SLKRVTFALPDDAETEDTGVLN---VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
+R + + + LN + +NS ++ ++ Q K E + KE+L +
Sbjct: 452 EAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAM----KEVLSVQK 507
Query: 384 WQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
G V+ PE+ ++ HF H +R +TEE +++KQ +++ +
Sbjct: 508 QMKLGLVS----PES--MDNYSHF-HELR----VTEEEI----NVLKQDLQNA----LEE 548
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
E+ KE E +++L ++ EK + + E E +K + E N E L
Sbjct: 549 SERNKEKVRELEEKL-VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA-------FL 600
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K EI + + M + A D I E NK
Sbjct: 601 FEKYQEAQE----------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ--- 647
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLT 623
+E + K+ + + Y+KR KS D +Y EKL QLT
Sbjct: 648 --VSELSQLYKEAQAELEDYRKR--------------KSLEDVTAEYIHKAEHEKLMQLT 691
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKM--QINDAKK 663
+A + AL ++ +SK+ +++ Q+ DA+K
Sbjct: 692 NVSRAK------AEDALSEMKSQYSKVLNELTQLKQLVDAQK 727
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 336 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 395
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 396 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 455
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 456 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 512
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 513 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 571
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 572 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 631
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 632 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 684
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 685 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 744
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 745 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 804
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 805 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 851
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 852 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 910
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 384 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 438
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 439 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 498
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 499 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 555
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 556 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 615
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 616 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 664
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 665 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 724
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 725 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 778
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 779 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 838
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 839 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 898
Score = 43.1 bits (100), Expect = 8e-04
Identities = 117/582 (20%), Positives = 214/582 (36%), Gaps = 127/582 (21%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D + +Q SK+ ++ G P+++
Sbjct: 206 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR 265
Query: 198 --------------------------SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEE 231
S + FF +A + +I + ++R D+
Sbjct: 266 KAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTT-- 323
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFD------PVESDEDIT--NVH 283
D DI S+ D+ L L++ +S L K+ D P E++ D++ + H
Sbjct: 324 -GADSLLDISSEADQQDLLSL--LQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYH 380
Query: 284 DDELDSNKEDDEIAEEEAEE-----------LSISETDEDDDLQENEDNKQ------HKE 326
+ D + E + L S TD D +Q+ ++ Q
Sbjct: 381 STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESS 440
Query: 327 SLKRVTFALPDDAETEDTGVLN---VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
+R + + + LN + +NS ++ ++ Q K E + KE+L +
Sbjct: 441 EAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAM----KEVLSVQK 496
Query: 384 WQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
G V+ PE+ ++ HF H +R +TEE +++KQ +++ +
Sbjct: 497 QMKLGLVS----PES--MDNYSHF-HELR----VTEEEI----NVLKQDLQNA----LEE 537
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
E+ KE E +++L ++ EK + + E E +K + E N E L
Sbjct: 538 SERNKEKVRELEEKL-VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA-------FL 589
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K EI + + M + A D I E NK
Sbjct: 590 FEKYQEAQE----------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ--- 636
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLT 623
+E + K+ + + Y+KR KS D +Y EKL QLT
Sbjct: 637 --VSELSQLYKEAQAELEDYRKR--------------KSLEDVTAEYIHKAEHEKLMQLT 680
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKM--QINDAKK 663
+A + AL ++ +SK+ +++ Q+ DA+K
Sbjct: 681 NVSRAK------AEDALSEMKSQYSKVLNELTQLKQLVDAQK 716
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 315 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 374
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 375 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 434
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 435 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 491
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 492 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 550
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 551 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 610
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 611 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 663
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 664 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 723
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 724 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 783
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 784 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 830
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 831 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 889
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 363 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 417
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 418 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 477
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 478 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 534
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 535 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 594
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 595 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 643
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 644 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 703
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 704 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 757
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 758 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 817
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 818 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 877
Score = 42.7 bits (99), Expect = 0.001
Identities = 116/556 (20%), Positives = 208/556 (37%), Gaps = 104/556 (18%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D +K +Q S V +
Sbjct: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP---TKPKQLSDVSSPRSITSTPL 270
Query: 198 SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKS 257
S + FF +A + +I + ++R D+ D DI S+ D+ L L++
Sbjct: 271 SGKESVFFAEPPFKAEISSIRENKDRLSDSTT---GADSLLDISSEADQQDLLSL--LQA 325
Query: 258 GKSSRNLKYKDFFD------PVESDEDIT--NVHDDELDSNKEDDEIAEEEAEE------ 303
+S L K+ D P E++ D++ + H + D + E +
Sbjct: 326 KVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPS 385
Query: 304 -----LSISETDEDDDLQENEDNKQ------HKESLKRVTFALPDDAETEDTGVLN---V 349
L S TD D +Q+ ++ Q +R + + + LN +
Sbjct: 386 VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI 445
Query: 350 KKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDH 409
+NS ++ ++ Q K E + KE+L + G V+ PE+ ++ HF H
Sbjct: 446 SENSSDLSQKLKETQSKYEEAM----KEVLSVQKQMKLGLVS----PES--MDNYSHF-H 494
Query: 410 AVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSL 469
+R +TEE +++KQ +++ + E+ KE E +++L ++ EK +
Sbjct: 495 ELR----VTEEEI----NVLKQDLQNA----LEESERNKEKVRELEEKL-VEREKGTVIK 541
Query: 470 AEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSN 529
+ E E +K + E N E LF K EI + +
Sbjct: 542 PPVEEYEEMKSSYCSVIENMNKEKA-------FLFEKYQEAQE----------EIMKLKD 584
Query: 530 LPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKI 589
M + A D I E NK +E + K+ + + Y+KR
Sbjct: 585 TLKSQMTQEASDEAEDMKEAMNRMIDELNKQ-----VSELSQLYKEAQAELEDYRKR--- 636
Query: 590 KEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSK 649
KS D +Y EKL QLT +A + AL ++ +SK
Sbjct: 637 -----------KSLEDVTAEYIHKAEHEKLMQLTNVSRAK------AEDALSEMKSQYSK 679
Query: 650 LQDQVKM--QINDAKK 663
+ +++ Q+ DA+K
Sbjct: 680 VLNELTQLKQLVDAQK 695
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 404 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 463
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 464 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 520
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 521 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 579
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 580 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 639
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 640 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 692
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 693 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 752
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 753 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 812
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 813 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 859
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 860 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 392 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 446
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 447 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 506
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 507 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 563
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 564 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 623
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 624 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 672
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 673 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 732
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 733 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 786
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 787 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 846
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 847 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 906
Score = 43.1 bits (100), Expect = 8e-04
Identities = 117/582 (20%), Positives = 214/582 (36%), Gaps = 127/582 (21%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D + +Q SK+ ++ G P+++
Sbjct: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR 273
Query: 198 --------------------------SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEE 231
S + FF +A + +I + ++R D+
Sbjct: 274 KAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTT-- 331
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFD------PVESDEDIT--NVH 283
D DI S+ D+ L L++ +S L K+ D P E++ D++ + H
Sbjct: 332 -GADSLLDISSEADQQDLLSL--LQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYH 388
Query: 284 DDELDSNKEDDEIAEEEAEE-----------LSISETDEDDDLQENEDNKQ------HKE 326
+ D + E + L S TD D +Q+ ++ Q
Sbjct: 389 STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESS 448
Query: 327 SLKRVTFALPDDAETEDTGVLN---VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
+R + + + LN + +NS ++ ++ Q K E + KE+L +
Sbjct: 449 EAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAM----KEVLSVQK 504
Query: 384 WQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
G V+ PE+ ++ HF H +R +TEE +++KQ +++ +
Sbjct: 505 QMKLGLVS----PES--MDNYSHF-HELR----VTEEEI----NVLKQDLQNA----LEE 545
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
E+ KE E +++L ++ EK + + E E +K + E N E L
Sbjct: 546 SERNKEKVRELEEKL-VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA-------FL 597
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K EI + + M + A D I E NK
Sbjct: 598 FEKYQEAQE----------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ--- 644
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLT 623
+E + K+ + + Y+KR KS D +Y EKL QLT
Sbjct: 645 --VSELSQLYKEAQAELEDYRKR--------------KSLEDVTAEYIHKAEHEKLMQLT 688
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKM--QINDAKK 663
+A + AL ++ +SK+ +++ Q+ DA+K
Sbjct: 689 NVSRAK------AEDALSEMKSQYSKVLNELTQLKQLVDAQK 724
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 404 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 463
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 464 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 520
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 521 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 579
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 580 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 639
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 640 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 692
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 693 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 752
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 753 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 812
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 813 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 859
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 860 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 392 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 446
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 447 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 506
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 507 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 563
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 564 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 623
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 624 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 672
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 673 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 732
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 733 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 786
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 787 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 846
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 847 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 906
Score = 43.1 bits (100), Expect = 8e-04
Identities = 117/582 (20%), Positives = 214/582 (36%), Gaps = 127/582 (21%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D + +Q SK+ ++ G P+++
Sbjct: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR 273
Query: 198 --------------------------SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEE 231
S + FF +A + +I + ++R D+
Sbjct: 274 KAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTT-- 331
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFD------PVESDEDIT--NVH 283
D DI S+ D+ L L++ +S L K+ D P E++ D++ + H
Sbjct: 332 -GADSLLDISSEADQQDLLSL--LQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYH 388
Query: 284 DDELDSNKEDDEIAEEEAEE-----------LSISETDEDDDLQENEDNKQ------HKE 326
+ D + E + L S TD D +Q+ ++ Q
Sbjct: 389 STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESS 448
Query: 327 SLKRVTFALPDDAETEDTGVLN---VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
+R + + + LN + +NS ++ ++ Q K E + KE+L +
Sbjct: 449 EAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAM----KEVLSVQK 504
Query: 384 WQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
G V+ PE+ ++ HF H +R +TEE +++KQ +++ +
Sbjct: 505 QMKLGLVS----PES--MDNYSHF-HELR----VTEEEI----NVLKQDLQNA----LEE 545
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
E+ KE E +++L ++ EK + + E E +K + E N E L
Sbjct: 546 SERNKEKVRELEEKL-VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA-------FL 597
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K EI + + M + A D I E NK
Sbjct: 598 FEKYQEAQE----------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ--- 644
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLT 623
+E + K+ + + Y+KR KS D +Y EKL QLT
Sbjct: 645 --VSELSQLYKEAQAELEDYRKR--------------KSLEDVTAEYIHKAEHEKLMQLT 688
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKM--QINDAKK 663
+A + AL ++ +SK+ +++ Q+ DA+K
Sbjct: 689 NVSRAK------AEDALSEMKSQYSKVLNELTQLKQLVDAQK 724
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.2 bits (178), Expect = 8e-13
Identities = 120/599 (20%), Positives = 249/599 (41%), Gaps = 74/599 (12%)
Query: 126 DKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS---DLDFDISKLEQ 182
D++DL L + +V+ + + E+ ++ + S + F S DL + K +
Sbjct: 344 DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGE 403
Query: 183 QSKVQNKGQGKPREKSI---VDDKFFKLSEMEAYLENIEK-----EEERKD---DNDEEE 231
S +K S+ D ++ +++ L++++K E ERK +
Sbjct: 404 TSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR 463
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
++ + + E+ L S+KLK +S K+ V+ + V + +D+
Sbjct: 464 AELVCLNNTEISENSSDL--SQKLKETQSKYEEAMKEVLS-VQKQMKLGLVSPESMDNYS 520
Query: 292 EDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLK-------RVTFALPDDAETED- 343
E+ E EE+++ + D + L+E+E NK+ L+ + T P E E+
Sbjct: 521 HFHELRVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 579
Query: 344 -TGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
+ +V +N ++ K+ ++ ++ E+I L+ L + + E K N +++
Sbjct: 580 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 639
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
E + V + +E +LED K++ + +DV + K + + + +
Sbjct: 640 E---LNKQVSELSQLYKEAQAELEDYRKRK----SLEDVTAEYIHKAEHEKLMQLTNVSR 692
Query: 463 EKSKLSLAEIYEQ------EYIKLNQQKTAEEENP----EHVEIQKMMDSLFLKLDA-LS 511
K++ +L+E+ Q E +L Q A++EN EH+++ + + +++ +S
Sbjct: 693 AKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 752
Query: 512 NF-HFIPKPPVPEIKVVSNL------------PAITMEEVAPVSVSDAALLAP---EEIK 555
N + V K+ L P + E++ S+ ++LA E +K
Sbjct: 753 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 812
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVA 615
EK K + KRE K+ Q +K KE+E +LL+K A
Sbjct: 813 EKEKVHSEVVQIRSEVSQVKRE--KENIQTLLKSKEQEV-NELLQKFQ----------QA 859
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
E+L ++ + ++S +E KDK + +KL++ + + T K++ Q +
Sbjct: 860 QEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 918
Score = 47.0 bits (110), Expect = 6e-05
Identities = 102/540 (18%), Positives = 220/540 (40%), Gaps = 65/540 (12%)
Query: 16 TEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLV------IE 69
T++G + G+P + +S + +++ K + + LQ+++ +E
Sbjct: 392 TDLGPSLGKPG-----ETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLE 446
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+ + E+ Q+ELQ+ N + N D+S + + + EE E+ + K+
Sbjct: 447 SSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM 506
Query: 130 LEDLEEEEVSDMGNDDPEMGERAE--NSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ 187
L E D + E+ E N K DL+ + S+ + + + +LE++ +
Sbjct: 507 KLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE---KVRELEEKLVER 563
Query: 188 NKG---------------------QGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDD 226
KG + +EK+ + +K+ + E L++ K + ++
Sbjct: 564 EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEA 623
Query: 227 NDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE------SDEDIT 280
+DE E D E ++ DE L S + YK+ +E S ED+T
Sbjct: 624 SDEAE---DMKEAMNRMIDE--------LNKQVSELSQLYKEAQAELEDYRKRKSLEDVT 672
Query: 281 N--VHDDELDSNKEDDEIAEEEAEE-LSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
+H E + + ++ +AE+ LS ++ L E KQ ++ K + ++ +
Sbjct: 673 AEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITE 732
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE 397
+ T + K +E S+ ++ ++A LEK+LLE+K +T P
Sbjct: 733 HLQVITT-LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEK-----AAMTDAMVPR 786
Query: 398 NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKR 457
+S + + V + +E+ + E + + ++ ++ V++EK K
Sbjct: 787 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKE 846
Query: 458 LTLDH--EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHF 515
++ +K + + E+ E + + K E+++ + E+ K + L L++LS +
Sbjct: 847 QEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSY 906
Score = 43.1 bits (100), Expect = 8e-04
Identities = 117/582 (20%), Positives = 214/582 (36%), Gaps = 127/582 (21%)
Query: 138 VSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
V +G + + +EN+ L S + D D + +Q SK+ ++ G P+++
Sbjct: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKR 273
Query: 198 --------------------------SIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEE 231
S + FF +A + +I + ++R D+
Sbjct: 274 KAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTT-- 331
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFD------PVESDEDIT--NVH 283
D DI S+ D+ L L++ +S L K+ D P E++ D++ + H
Sbjct: 332 -GADSLLDISSEADQQDLLSL--LQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYH 388
Query: 284 DDELDSNKEDDEIAEEEAEE-----------LSISETDEDDDLQENEDNKQ------HKE 326
+ D + E + L S TD D +Q+ ++ Q
Sbjct: 389 STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESS 448
Query: 327 SLKRVTFALPDDAETEDTGVLN---VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
+R + + + LN + +NS ++ ++ Q K E + KE+L +
Sbjct: 449 EAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAM----KEVLSVQK 504
Query: 384 WQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
G V+ PE+ ++ HF H +R +TEE +++KQ +++ +
Sbjct: 505 QMKLGLVS----PES--MDNYSHF-HELR----VTEEEI----NVLKQDLQNA----LEE 545
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
E+ KE E +++L ++ EK + + E E +K + E N E L
Sbjct: 546 SERNKEKVRELEEKL-VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA-------FL 597
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K EI + + M + A D I E NK
Sbjct: 598 FEKYQEAQE----------EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQ--- 644
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLT 623
+E + K+ + + Y+KR KS D +Y EKL QLT
Sbjct: 645 --VSELSQLYKEAQAELEDYRKR--------------KSLEDVTAEYIHKAEHEKLMQLT 688
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKM--QINDAKK 663
+A + AL ++ +SK+ +++ Q+ DA+K
Sbjct: 689 NVSRAK------AEDALSEMKSQYSKVLNELTQLKQLVDAQK 724
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 71.2 bits (173), Expect = 3e-12
Identities = 124/627 (19%), Positives = 261/627 (41%), Gaps = 72/627 (11%)
Query: 100 NDEDISLLPESEEQEREEDGSE--------IEADDKEDLEDLEEEEVSDMGNDDPEMGER 151
ND + + E+E E+ E +EA KE E LEEEE EM
Sbjct: 889 NDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEE---------EMNSE 939
Query: 152 AENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKV-QNKGQGKPREKSIVDDKFFKLSEM 210
++ K + DL+ ++K+E++ +NK + E + +++ KL++
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 211 EAYLENIEKEEERKDDNDEEEEDIDFFEDIDS------DEDEGGLFGSKKLKSGKSSRNL 264
+ L+ E ++ DD EE+ ++ I++ D+ EG L KKL++
Sbjct: 1000 KKSLQ--EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR 1057
Query: 265 KYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQH 324
K + D S E I ++ +D+ + ++++ ++E E + +D+ + + K+
Sbjct: 1058 KLEG--DLKMSQESIMDLENDK---QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI 1112
Query: 325 KESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNE--------------K 370
KE R+ L ++ E E T ++K ++ E+ E++ E +
Sbjct: 1113 KELQARIE-ELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171
Query: 371 IASLEKELLEKKPWQLQGEVTA---QKRPENSLLEETLHFDHAVRMAPVITEETT---LQ 424
A +K + + LQ E TA +K+ +S+ E D+ R+ + +E + ++
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 425 LEDIIKQ-RIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQ 483
++D+ ++ ++ R + ED + K D ++++L I++ K Q
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIK--AKDEQQTQL----IHDLNMQKARLQ 1285
Query: 484 KTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSV 543
E + E + ++ L AL+ K + E N A ++ S
Sbjct: 1286 TQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS----SR 1341
Query: 544 SDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRK----LL 599
D LL + +E+ +++ A K ++ + R K + + +E E+ +K L
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 600 EKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKD----KALKSSQAFFSKLQDQVK 655
+++ + SK + EK KQ + ++D + L Q F K+ + K
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 656 MQINDAK-KTEKKKKKRQDISVHKLKL 681
++++++ + E +K+ + +S K+
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKM 1488
Score = 67.8 bits (164), Expect = 3e-11
Identities = 118/622 (18%), Positives = 252/622 (40%), Gaps = 74/622 (11%)
Query: 74 EQIWQQLELQNEPILQYFQNAVSETINDE--DISLLPESEEQEREEDGSEIEADDKEDLE 131
E++ +Q+E + + +NA++ + D LL E E+E+E +A+ + L
Sbjct: 1317 EELKRQMEEETKA-----KNAMAHALQSSRHDCDLLREQYEEEQEA-----KAELQRALS 1366
Query: 132 DLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQ 191
E + + +R E ++ + + + + + + SK K + + Q
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ 1426
Query: 192 GKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFG 251
G+ V+D L ++K++ D E + DE + L
Sbjct: 1427 GE------VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQ-------KLDESQAELEA 1473
Query: 252 SKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDE 311
++K S+ K ++ ++ V D+L++ + +++ +EE +L+ +
Sbjct: 1474 AQKESRSLSTELFKMRNAYEEVV----------DQLETLRRENKNLQEEISDLTEQIAET 1523
Query: 312 DDDLQENEDNK----QHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKM 367
+LQE E K Q K L+ + E E++ +L V+ +VKS +++ +
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK 1583
Query: 368 NEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLED 427
+E+I L++ ++ LQ + A+ R N L + + + + Q+ +
Sbjct: 1584 DEEIEQLKRNS-QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 428 IIK--QRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKT 485
K + ++ Q D + + + K++L + ++ L L E+ E + ++T
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERT 1702
Query: 486 AEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVV---SNLPAITMEEVAPVS 542
E ++ + L + +L N + + + + S + EE A +
Sbjct: 1703 RRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Query: 543 VSDAALLAPEEIKEKNKAGDI---KTAAEKTATD-----KKRERRKKKYQKRMKIKEKEK 594
++DAA++A E KE++ + + K E+T D + E+ K K+ K + +
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENR 1822
Query: 595 RRKLLEKSSVDQ---------AGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQA 645
R+L + V+Q A KY + K+K++T + E K + Q
Sbjct: 1823 VRELENELDVEQKRGAEALKGAHKYER-----KVKEMT-------YQAEEDHKNILRLQD 1870
Query: 646 FFSKLQDQVKMQINDAKKTEKK 667
KLQ +VK A++ E++
Sbjct: 1871 LVDKLQAKVKSYKRQAEEAEEQ 1892
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.8 bits (164), Expect = 3e-11
Identities = 139/711 (19%), Positives = 306/711 (43%), Gaps = 61/711 (8%)
Query: 11 LERCLTEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIEN 70
LE+ L ++G + + + + + L K D ++ G + L +L +N
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
Query: 71 FDDE----QIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADD 126
+ Q+ ++L+ Q+E Q +N + + + E +E+ +
Sbjct: 571 HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL 630
Query: 127 KEDLEDLEEEEVSDMGNDDPEMG-ERAENSSKSDLRK-----SPVFSDEDSDLDFDISKL 180
E E + + ++ + + E A+ + ++DL+ D+ +L+ ++L
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 181 EQ-QSKVQNKGQGKPREKSIVDD---KFFKLS----EMEAYLENIEKEE-ERKDDNDEEE 231
+Q +K+Q+K + + +S + + K+ L E+E ++ +E + E K ++
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 232 EDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNK 291
+D+ +++D + SK+L+ K + D E+ E I +L +
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ----KLTKQE 806
Query: 292 EDDEIAEEEAEELSISETDEDDDLQEN-EDNKQHKESLKRVTFALPDDAETEDTGVLNVK 350
E+ +I +++ E LS + ++L + + +K AL + T + V
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 351 KNSDEVKSSFEKRQEKMNEKIASLEKELLE-KKPWQLQGEVTAQKRPE-NSLLEETLHFD 408
+ KS FEK +K I LEK E K Q+Q E T +++ E LE+
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926
Query: 409 HAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLS 468
H +++ +E +Q ++ +KQ +++ E K+ + + KK++ + K++
Sbjct: 927 HQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL-KQSSEQKKKQIEALQGELKIA 985
Query: 469 LAEIYEQEYIKLNQQKT-AEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVV 527
+ + E E KL QQ T A +E E K+ L N + + +++
Sbjct: 986 VLQKTELEN-KLQQQLTQAAQELAAEKE----------KISVLQNNYEKSQETFKQLQ-- 1032
Query: 528 SNLPAITMEEVAP----VSVSDAALLAPEE-IKEKNKAG-------DIKTAAEKTATDKK 575
S+ E +A SV + LA E+ I +N+ G ++KTA K ++
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTA--KATLEQD 1090
Query: 576 RERRKKKYQKRMK-IKEKEKRRKLLEKSSVDQAGKYS--KTVASEKLKQLTKTG---KAS 629
+++++ Q+R K +++ +K + L EK V++ K + + + + K++TK K+
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSH 1150
Query: 630 FIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLK 680
++ + LK ++ + + +++ + + K +++K+ Q I ++K
Sbjct: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
Score = 65.9 bits (159), Expect = 1e-10
Identities = 141/689 (20%), Positives = 291/689 (42%), Gaps = 91/689 (13%)
Query: 31 IQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQ-------QLELQ 83
+Q L++ TSL ++ + ++ G QKL E + E +Q QL+ Q
Sbjct: 349 LQSRLSASETSLHRIHVELSE-------KGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 84 NEPILQYFQNAVSETINDEDISLLPESEEQEREEDG--SEIEADDKEDLEDLEEEEVSDM 141
E Q+ SE IN LL E+E Q E G E E L D +E++V+D+
Sbjct: 402 REEKEQHGLQLQSE-INQLHSKLL-ETERQLGEAHGRLKEQRQLSSEKLMD-KEQQVADL 458
Query: 142 ----GNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPRE- 196
+ ++ E+ NS++ LD + ++Q +Q K RE
Sbjct: 459 QLKLSRLEEQLKEKVTNSTELQ-----------HQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 197 KSIVDDKFFKLSEMEAYLENIEKEEERKDDNDE--EEEDIDFFEDIDSDEDEGGLFGSKK 254
++ ++ ++ + + ++N+E ++ +N E+E D + I + E E + +
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 255 LKSGKSSRNLKY--KDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDED 312
K+ + + + ES + D++ K A++ L S + +
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 313 DDLQENEDNKQHKESLKRVTFALPDDAETEDTGV-LNVKKNSDEVKSSFEKRQEKMNEKI 371
L E+++ + + L AE T +++ + D +++ + +Q+++N+
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 372 ASLEK---ELLEKKPW--QLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLE 426
L++ +L +K+ QL+ + K SL ++T + ++ L+ +
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK---------LEAD 738
Query: 427 DIIKQRIRDQAWDDVVRKEKPKED----AYEYKKRLTLDHE---KSKLSLAEIYEQ-EYI 478
+ + ++QA D+ ++ + D A E K+L ++ E ++L L + E E I
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 479 KLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEV 538
K K EE+ + + + ++ + L+N + V E++ V M E+
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI---QTTVTELQKVKMEKEALMTEL 855
Query: 539 APVS-----VSDAALLAPEEIKEKNKAGDIKTA-AEKTATDKKRERRKKKYQKRMKIKEK 592
+ V VSD+ + E +++N+ G EKT + K + + Q +KE+
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ---VQMENTLKEQ 912
Query: 593 EKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQD 652
++ +K LEK AS +LK + + I+ + LK ++ K +
Sbjct: 913 KELKKSLEKEKE----------ASHQLKLELNSMQEQLIQAQN---TLKQNE----KEEQ 955
Query: 653 QVKMQINDAKKTEKKKKKRQDISVHKLKL 681
Q++ IN+ K++ ++KKK+ + +LK+
Sbjct: 956 QLQGNINELKQSSEQKKKQIEALQGELKI 984
Score = 49.7 bits (117), Expect = 9e-06
Identities = 127/609 (20%), Positives = 253/609 (41%), Gaps = 80/609 (13%)
Query: 30 TIQEGLASKFTSLTKVLYDFNKI---LENGRIHGSPLQKLVIENFDD----EQIWQQLEL 82
T Q L K L K+ +++ L++ + H S L+ + E + EQ ++LE
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 83 QNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMG 142
Q + + A S + L + ++Q + E+ A + ++E+E VS
Sbjct: 731 QIKKL-----EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 143 NDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDD 202
D + E E S K L K +E L D L Q++K+Q++ + ++ +
Sbjct: 786 LDLQKKSEALE-SIKQKLTKQ---EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841
Query: 203 KFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSR 262
+ K+ + E +++ +D + FE E++ G L+ K+ +
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK----ENQKGKAAILDLE--KTCK 895
Query: 263 NLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNK 322
LK++ ++ + T EL + E ++ A + + L ++ E +N +
Sbjct: 896 ELKHQ-----LQVQMENTLKEQKELKKSLEKEKEASHQLK-LELNSMQEQLIQAQNTLKQ 949
Query: 323 QHKESLKRVTFALPDDAETEDTGVLN-VKKNSDEVKSSFEKRQEKMNEKIASLEKELLEK 381
KE E + G +N +K++S++ K E Q ++ KIA L+K LE
Sbjct: 950 NEKE-------------EQQLQGNINELKQSSEQKKKQIEALQGEL--KIAVLQKTELEN 994
Query: 382 KPWQLQGEVT------AQKRPENSLLEET----------LHFDHAVRMAPVIT------- 418
K LQ ++T A ++ + S+L+ L D R + ++
Sbjct: 995 K---LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051
Query: 419 --EETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEY---KKRLTLDHEKSKLSLAEIY 473
E+ +L ED+I R + + ++++ K + E KK L E+ K +L +I
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ-ERCK-ALQDIQ 1109
Query: 474 EQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAI 533
+++ +K + + + E EI+ + KL+ H + + EI + + +
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES--IKEITNLKDAKQL 1167
Query: 534 TMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKE 593
+++ + +L A E +EK +K +K + K+E +K+ + +IKEKE
Sbjct: 1168 LIQQKLELQGKADSLKAAVE-QEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
Query: 594 KRRKLLEKS 602
K E++
Sbjct: 1227 VGMKKHEEN 1235
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 67.4 bits (163), Expect = 4e-11
Identities = 119/626 (19%), Positives = 256/626 (40%), Gaps = 82/626 (13%)
Query: 74 EQIWQQLELQNEPILQYFQNAVSETINDE--DISLLPESEEQEREEDGSEIEADDKEDLE 131
E++ +QLE +N+ +NA++ + D LL E E+E+E +A+ + L
Sbjct: 1314 EELKRQLEEENKA-----KNALAHALQSSRHDCDLLREQYEEEQEG-----KAELQRALS 1363
Query: 132 DLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQ 191
E + + +R E ++ + + D + ++ +K K + + Q
Sbjct: 1364 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 192 GKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFG 251
G+ V+D + + ++K++ D E + +E + L
Sbjct: 1424 GE------VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKT-------KCEESQAELEA 1470
Query: 252 SKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDE 311
S K S+ K K+ ++ D+L++ K +++ E+E +L+ +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEAL----------DQLETVKRENKNLEQEIADLTEQIAEN 1520
Query: 312 DDDLQENEDNKQHKESLKRVTFALPDDAET----EDTGVLNVKKNSDEVKSSFEKRQEKM 367
+ E E +++ E K ++AE E+ +L ++ +VKS +++ +
Sbjct: 1521 GKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 368 NEKIASLEKEL---LEKKPWQLQGEVTAQ-------KRPENSLLEETLHFDHAVRMAPVI 417
+E+I L++ +E L EV ++ K+ E L E + HA R A
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640
Query: 418 TE----------ETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKL 467
+ +T L L+D ++ + + +V + A + R TL+ +
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 468 SLAEIYEQEYIKLNQQ-KTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKV 526
LAE QE + N++ + +N + +K +++ ++L + E++
Sbjct: 1701 KLAE---QELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS-------------EVED 1744
Query: 527 VSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKR 586
S A EE A +++DAA++A E KE++ + ++ + K + + ++
Sbjct: 1745 ASR-DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
Query: 587 MKIKEKEKRRKLLE----KSSVDQAGKYSKTVASEK-LKQLTKTGKASFIKDEGKDKALK 641
+ +K +K+ + LE + + G+ K S K L++ + K + E K +
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Query: 642 SSQAFFSKLQDQVKMQINDAKKTEKK 667
Q KLQ +VK A++ +++
Sbjct: 1864 RLQDLVDKLQVKVKSYKRQAEEADEQ 1889
Score = 41.6 bits (96), Expect = 0.002
Identities = 130/693 (18%), Positives = 253/693 (36%), Gaps = 127/693 (18%)
Query: 81 ELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDG---SEIEADDKEDLE------ 131
EL+ E + A +E + L E E+ E G ++IE + K + E
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 132 DLEEEEVSDMG----------NDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLE 181
DLEE + + E+GE+ +N R E S+ +I L
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ----RVKQKLEKEKSEFKLEIDDLS 1233
Query: 182 QQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKE--EERKDDNDEEEEDIDFFED 239
S +++ + K + I +LSE E I++ E + + E +
Sbjct: 1234 --SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 240 IDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEE 299
++ E K + + LK + +E + N L S++ D ++ E
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQTEELKRQ-----LEEENKAKNALAHALQSSRHDCDLLRE 1346
Query: 300 EAEE-----------LSISETD--------EDDDLQENEDNKQHKESLKRVTFALPDDAE 340
+ EE LS + ++ E D +Q E+ ++ K+ L + + E
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406
Query: 341 TEDTGVLNVKKNSDEVKSSFEKRQ---EKMNEKIASLEKELL---------EKKPWQLQG 388
+ +++K ++ E E+ N A+L+K+ + K + Q
Sbjct: 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 389 EVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPK 448
E+ A + SL E +A A + ET + ++Q I D + + K
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEA-LDQLETVKRENKNLEQEIADLT-EQIAENGKTI 1524
Query: 449 EDAYEYKKRL----------------TLDHEKSKL----------------SLAEIYEQ- 475
+ + +K++ L+HE++K+ +AE E+
Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEI 1584
Query: 476 EYIKLNQQKTAEE-ENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAIT 534
E +K N Q+T E ++ E++ +++ LK + + I ++ + A T
Sbjct: 1585 EQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI----QLSHANRQAAET 1640
Query: 535 MEEVAPVS--VSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEK 592
++ + V + D L + ++ + + E+ A + E + R +++
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVE----ELRATLEQT 1696
Query: 593 EKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGK--------DKALKSSQ 644
E+ RKL E+ +D S + QL T S I + K ++ +
Sbjct: 1697 ERARKLAEQELLD----------SNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 645 AFFSKLQDQVKMQINDAKKTEKKKKKRQDISVH 677
+++ K I DA ++ KK QD S H
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.0 bits (162), Expect = 5e-11
Identities = 139/629 (22%), Positives = 264/629 (41%), Gaps = 95/629 (15%)
Query: 85 EPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGND 144
E LQ Q + E N + +SL + ++ E E++ + +++E+ + E++++ +
Sbjct: 1307 ESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 145 DPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNK-GQGKPREKSIVDDK 203
+M ++ E+S V DL+ + E++ +K + K R + +DD
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 204 FFKLSEMEAYLENIEKEEERKDDNDEEEEDID--FFEDIDSDEDEGGLFGSKKLKSGKSS 261
L N+EK++++ D EE+ I + E+ D E E K+ K+ +
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR---EKETKALSLA 1482
Query: 262 RNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDN 321
R L+ + +E ++ + NK+ E E+L S+ D + E E +
Sbjct: 1483 RALE-----EAMEQKAELERL-------NKQ----FRTEMEDLMSSKDDVGKSVHELEKS 1526
Query: 322 K----QHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEK----RQEKMNEKIAS 373
K Q E +K L D+ + + L ++ N +K+ FE+ R E+ EK
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 374 LEKEL------LEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLED 427
L +++ LE + Q V A+K+ E L + H D A + ++
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK-----------NRDE 1635
Query: 428 IIKQRIRDQA-WDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTA 486
IKQ + QA D +R+ + E ++EK S+ E E I+L ++ A
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM----EAEMIQLQEELAA 1691
Query: 487 EEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDA 546
E + ++ D L++ EI S A+ +EE + A
Sbjct: 1692 AERAKRQAQQER---------DELAD----------EIANSSGKGALALEEKRRLEARIA 1732
Query: 547 ALLAPEEIKEKNKAGDIKTAAEKTA--------TDKKRER----RKKKYQKRMKIKEKEK 594
L EE++E+ ++ K A TD ER + + +++++ + KE
Sbjct: 1733 QL--EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 595 RRKLLE-KSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDK--ALKSSQAFFSKLQ 651
+ KL E + +V K S T K+ QL + + +E K++ A K + KL+
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQ-----LDNETKERQAACKQVRRTEKKLK 1845
Query: 652 DQVKMQINDAKKTEKKKKKRQDISVHKLK 680
D V +Q++D ++ ++ K + D + +LK
Sbjct: 1846 D-VLLQVDDERRNAEQYKDQADKASTRLK 1873
Score = 61.6 bits (148), Expect = 2e-09
Identities = 140/681 (20%), Positives = 280/681 (41%), Gaps = 97/681 (14%)
Query: 35 LASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNA 94
L +K L ++ +D +E Q L E +Q Q+LE Q E Q
Sbjct: 906 LTAKKQELEEICHDLEARVEEEE---ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 95 VSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAEN 154
E + E L EEQ ED + A +K+ LED E +++ ++ E++++
Sbjct: 963 QLEKVTTE-AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE----EKSKS 1017
Query: 155 SSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEM--EA 212
+K + + +D + L + + ++ K + K +G + S D+ +L E
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS---DQIAELQAQIAEL 1074
Query: 213 YLENIEKEEERKDDNDEEEED-------IDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLK 265
++ +KEEE + EE+ + +++S E + L+S ++SRN
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL----QEDLESERASRNKA 1130
Query: 266 YKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHK 325
K D E E + +D LDS E+ + +E++I + +++ + +E Q +
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE--AQIQ 1188
Query: 326 ESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQ 385
E ++ + A+ + AE + VK N ++ K + E + ++ ++ L
Sbjct: 1189 EMRQKHSQAVEELAEQLEQ-TKRVKANLEKAKQTLENERGELANEVKVL----------- 1236
Query: 386 LQGEVTAQ---KRPENSLLEETLHFDHAVRMAPVITEETT---LQLEDIIKQRIRDQAWD 439
LQG+ ++ K+ E L E + F+ R+ + ++ T ++L+++ + +
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 440 DVVRKE-KPKEDAYEYKKRLTLDHEKSKLSLA---EIYEQEYIKLNQQKTAEEENPEHVE 495
+ K+ E + + L + + KLSL+ + E E +Q EEE ++E
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 496 IQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIK 555
K ++ L A + + S L EE+K
Sbjct: 1357 -----------------------------KQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 556 ---EKNKAGDIKTAAEKTATDKKRERRKKKYQKRM-----KIKEKEKRRKLLEKSSVDQA 607
+K+ G + EK A K E+ K + Q+ + + + + LEK +
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK----KQ 1443
Query: 608 GKYSKTVASEK---LKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQ-INDAKK 663
K+ + +A EK K + +A E + KAL ++A ++ + +++ +N +
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 664 TEKK--KKKRQDI--SVHKLK 680
TE + + D+ SVH+L+
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELE 1524
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 67.0 bits (162), Expect = 5e-11
Identities = 143/711 (20%), Positives = 277/711 (38%), Gaps = 92/711 (12%)
Query: 35 LASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNA 94
++ K LTKV+Y N + H S +Q L ++ +E+I Q L E ILQY
Sbjct: 44 MSKKIAQLTKVIYALNTKNDE---HESAIQAL--KDAHEEEIQQILAETREKILQYKSKV 98
Query: 95 VSETINDEDISLLPESEEQE---REEDGSEIEADDKEDLEDLE-------EEEVSDMGND 144
E I +L S E +++ +E EA K +ED++ + + M +
Sbjct: 99 TEELDLRRKIQVLESSLEDHIKMKQQALTEFEAY-KHRVEDMQLCAEAQHVQRIVTMSRE 157
Query: 145 DPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQ-------------NKGQ 191
E+ + E +S + V ++D L + + + ++Q NKGQ
Sbjct: 158 VEEIRRKFEEKLRS-FGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 216
Query: 192 GKPREKSIVDDKFFKLSEMEAYLENIEKEEER--KDDNDEEEEDIDFFEDIDSDEDEGGL 249
K E ++ + + LE + E ++ +D + + F+E L
Sbjct: 217 EKAEELHRME-----VESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQL 271
Query: 250 FGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEEL----- 304
F ++ L++ K K+F + E I +L K + ++ ++EA L
Sbjct: 272 FTAESLQASKEKEADLRKEF----QGQEAILRKTIGKL---KTELQMVQDEAGSLLDKCQ 324
Query: 305 ------SISETDED------DDLQENE-----DNKQHKESLKRVTFALPDDA-----ETE 342
+I+E + DD +E E +K+ + L L A +
Sbjct: 325 KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKAS 384
Query: 343 DTGVLNVKKNSDEVK-SSFEKRQEKMNEKIASLEKE--LLEKKPWQLQGEVTAQ-----K 394
G+L + + EV E + ++NE+++ LE+E L K L E Q K
Sbjct: 385 HIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEK 444
Query: 395 RPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEY 454
+ + + +++ ++ EE QL + + + + AW + E +A
Sbjct: 445 KVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRD 504
Query: 455 KKRLTLD----HEKSKLSLAEIYEQEYIKLNQQKTAEEE--NPEHVEIQKMMDSLFLKLD 508
KK+L +D H K KL+L E Q +L K E+ N + EI + D +
Sbjct: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
Query: 509 ALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAA- 567
L + + + + N +T + + DA L E++++ + + AA
Sbjct: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLK--ETKDALLNVEGELEQERQQHEETIAAM 622
Query: 568 ---EKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTV-ASEKLKQLT 623
EK DK + K+ + ++ + + R +L + D+ S+ + ++ K
Sbjct: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAA 682
Query: 624 KTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDI 674
+ ++D +L Q Q +Q A+ T+++++ Q++
Sbjct: 683 RDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQEL 733
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 66.6 bits (161), Expect = 7e-11
Identities = 79/326 (24%), Positives = 147/326 (45%), Gaps = 35/326 (10%)
Query: 64 QKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISL-LPESEEQEREEDGSEI 122
Q + E DEQ +++ E ++ ++ DE +S +P + + + +++ E
Sbjct: 1175 QNSIGEGSSDEQ---KIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN 1231
Query: 123 EADDKEDLEDLEEEEVSD---MGNDDPEMGERA-----ENSSKSDLRKSPVFSDEDSDLD 174
K LE+++ SD +D+PE G++ E + + K+ V S+ DSD
Sbjct: 1232 RIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSD-- 1289
Query: 175 FDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIE-KEEERKDDNDEEEED 233
++SK R K V D + E+ E K R+ + E+ ED
Sbjct: 1290 ------SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED 1343
Query: 234 IDF-----FEDIDSDEDEGG--LFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDE 286
DF E++ EDE +KK + ++ R+ K K ++ ED ++ +++
Sbjct: 1344 SDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS--ENK 1401
Query: 287 LDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDD-AETEDTG 345
+S +E++E EEE EE E +E+++ EN+D+K + K++ L DD TE
Sbjct: 1402 SNSEEEEEEKEEEEEEE----EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQN 1457
Query: 346 VLNVKKNSDEVKSSFEKRQEKMNEKI 371
L ++ + + E+ +EK+ E I
Sbjct: 1458 ALKEEEERRKRIAEREREREKLREVI 1483
Score = 51.2 bits (121), Expect = 3e-06
Identities = 112/584 (19%), Positives = 232/584 (39%), Gaps = 74/584 (12%)
Query: 127 KEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKV 186
++ L D+ E+ + +D+ ++ ++ ++ +K P SD + K+EQQ +
Sbjct: 920 QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP------SDFKKKVIKMEQQYES 973
Query: 187 QNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEED--IDFFE------ 238
+ G K E+ + + +++ + EK+ ++ D +++D D+ E
Sbjct: 974 SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG 1033
Query: 239 -DIDSDEDE---GGLFGSKKLKS---GKSSRNLKYKDFFDPVESDEDITNVHDDELDSN- 290
DS ED+ G +G +K + GKSSR + D SD + ++ +D +S+
Sbjct: 1034 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ-----DCSSSDTEKYSMKEDGCNSSD 1088
Query: 291 KEDDEIAEEEAEELSI--------SETDEDDDLQENEDNKQHKESLKRVTFALPDDAETE 342
K I E LS S + D + +EDNK+ K+ ++
Sbjct: 1089 KRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQR-----------TSSK 1137
Query: 343 DTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
V+ +K + +++S +++Q I S +E GE ++ ++ + E
Sbjct: 1138 KKAVIVKEKKRNSLRTSTKRKQAD----ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE 1193
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
+ H E + + + D ++ + K+ E E K L+ D
Sbjct: 1194 NLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLE---EIKANLSSDE 1250
Query: 463 EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDS------------LFLKL--- 507
+ S E ++ K N++ +EE V + DS L KL
Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310
Query: 508 DALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAA 567
D S KP + N ++ E+ ++ + EE+ E +T +
Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGV--SEEVSESEDEQRPRTRS 1368
Query: 568 EKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGK 627
K A ++ +R K+ +KR +IK +E + +S ++ + + E+ ++ + +
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Query: 628 ASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKR 671
K GK + K + D+++ + +A K E++++KR
Sbjct: 1429 NDDSKSPGKGR--KKIRKILK--DDKLRTETQNALKEEEERRKR 1468
Score = 46.6 bits (109), Expect = 8e-05
Identities = 142/733 (19%), Positives = 272/733 (37%), Gaps = 172/733 (23%)
Query: 96 SETIN-----DEDISLLPE----SEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDP 146
SET++ DE +++L E S + D +EI + K L DL+ + G DD
Sbjct: 684 SETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKT-LYDLKTQA----GKDDK 738
Query: 147 EMGERAENSSKSDL-------RKSPVFS-------DEDSDLDFDISKLEQQSKVQNK-GQ 191
+R ++S SD KS + S E S+ D S+LE++ K +K G
Sbjct: 739 GKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYD---SELEKEIKSMSKIGA 795
Query: 192 GKPREKSIVDDKFFKLSEMEAYLE---------NIEKEEERKDDNDEEEEDIDFFEDIDS 242
+ +K I + K F SE E + + N++ +E D+ E +++ + F +
Sbjct: 796 ARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEG 855
Query: 243 DEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDED-ITNVHDDELDSNKEDD------- 294
D+ + + K + D D + E T++ ++ KE
Sbjct: 856 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 915
Query: 295 ---------EIAEEEAEELSISETDEDDDLQENEDNKQHKE--SLKRVTFALPDDAETED 343
+IAE+ ++ ET EDD Q + ++ K+ K+ + E+
Sbjct: 916 CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSS 975
Query: 344 TG---------VLNVKKNSDEVKSSF---EKRQEKMNEKIASLEKEL------------- 378
G + + K ++K+ EK+ +K+ +K + + EL
Sbjct: 976 DGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDS 1035
Query: 379 ---------------LEKKPWQLQGEVTAQKR-------PENSLLEETLHFDHAVRMAPV 416
EKK +L G+ + +++ + S+ E+ +
Sbjct: 1036 CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1095
Query: 417 ITEETTLQLEDIIKQRIRDQAWDDVVRK---EKPKEDAYEYKKRLTLDHEKSKLSLAEIY 473
+ E L + K+ + D K K+ KK+ + EK + SL
Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1155
Query: 474 EQEYIKLNQQKTAEEENPEHVEI-QKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPA 532
+++ + +++ E+ + I + D +K PV E V+S+
Sbjct: 1156 KRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK-------------PVTENLVLSSHTG 1202
Query: 533 I-------TMEEVAPVSVSD-----------AALLAPEEIK-----EKNKAGDIKTAAEK 569
+ + PV+V D A + EEIK +++ + D + K
Sbjct: 1203 FCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGK 1262
Query: 570 TATDKKRERRKKKYQKRMKI------------KEKEKRRKLLEKSSVD--QAGKYSKTVA 615
T K+ E + + ++ K + + R L K +V ++G+ KT
Sbjct: 1263 KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1322
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSS--QAFFSKLQDQVKMQINDAKKTE-------- 665
E K++ + ++ +D + S S+ +D+ + + AKK E
Sbjct: 1323 KEH-KEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY 1381
Query: 666 KKKKKRQDISVHK 678
K+KKKR+ I V +
Sbjct: 1382 KQKKKRRRIKVQE 1394
Score = 43.1 bits (100), Expect = 8e-04
Identities = 79/403 (19%), Positives = 157/403 (38%), Gaps = 34/403 (8%)
Query: 109 ESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENS-SKSDLRKSPVFS 167
+S E ++ ++G+ + L + D + D E E+ + SD R +
Sbjct: 1037 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIEL 1096
Query: 168 DEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKL---SEMEAYLENIEKEEERK 224
E +L S ++Q+ E+S D+K K S+ +A + +K +
Sbjct: 1097 RERRNL----SSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1152
Query: 225 DDNDEEEEDIDF-----FEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDI 279
++ DI ED D + G +K+K + L F DE +
Sbjct: 1153 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1212
Query: 280 TN----VHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFAL 335
+ DD+ D N ++ IA++ E + D+D +++ ++ K+ +
Sbjct: 1213 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1272
Query: 336 PDDAETEDTGVLNVKKNSDEVKSSFEK-RQEKMNEKIASLEKELLEKKPWQLQGEVTAQK 394
P D E ++ +N + +SD +S + R + K+ + E E+K + + +
Sbjct: 1273 PGDEEAKNQ--VNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKG 1330
Query: 395 RPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEY 454
R + E D + + V E + ED + R R +K + +E+ Y
Sbjct: 1331 RNRRKVSSEDSE-DSDFQESGV--SEEVSESEDEQRPRTRS------AKKAELEENQRSY 1381
Query: 455 K-----KRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPE 492
K +R+ + + S + + E+E K +++ EEE E
Sbjct: 1382 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1424
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 66.6 bits (161), Expect = 7e-11
Identities = 79/326 (24%), Positives = 147/326 (45%), Gaps = 35/326 (10%)
Query: 64 QKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISL-LPESEEQEREEDGSEI 122
Q + E DEQ +++ E ++ ++ DE +S +P + + + +++ E
Sbjct: 1213 QNSIGEGSSDEQ---KIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPEN 1269
Query: 123 EADDKEDLEDLEEEEVSD---MGNDDPEMGERA-----ENSSKSDLRKSPVFSDEDSDLD 174
K LE+++ SD +D+PE G++ E + + K+ V S+ DSD
Sbjct: 1270 RIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSD-- 1327
Query: 175 FDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIE-KEEERKDDNDEEEED 233
++SK R K V D + E+ E K R+ + E+ ED
Sbjct: 1328 ------SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED 1381
Query: 234 IDF-----FEDIDSDEDEGG--LFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDE 286
DF E++ EDE +KK + ++ R+ K K ++ ED ++ +++
Sbjct: 1382 SDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSS--ENK 1439
Query: 287 LDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDD-AETEDTG 345
+S +E++E EEE EE E +E+++ EN+D+K + K++ L DD TE
Sbjct: 1440 SNSEEEEEEKEEEEEEE----EEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQN 1495
Query: 346 VLNVKKNSDEVKSSFEKRQEKMNEKI 371
L ++ + + E+ +EK+ E I
Sbjct: 1496 ALKEEEERRKRIAEREREREKLREVI 1521
Score = 51.2 bits (121), Expect = 3e-06
Identities = 112/584 (19%), Positives = 232/584 (39%), Gaps = 74/584 (12%)
Query: 127 KEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKV 186
++ L D+ E+ + +D+ ++ ++ ++ +K P SD + K+EQQ +
Sbjct: 958 QDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP------SDFKKKVIKMEQQYES 1011
Query: 187 QNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEED--IDFFE------ 238
+ G K E+ + + +++ + EK+ ++ D +++D D+ E
Sbjct: 1012 SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKG 1071
Query: 239 -DIDSDEDE---GGLFGSKKLKS---GKSSRNLKYKDFFDPVESDEDITNVHDDELDSN- 290
DS ED+ G +G +K + GKSSR + D SD + ++ +D +S+
Sbjct: 1072 DSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ-----DCSSSDTEKYSMKEDGCNSSD 1126
Query: 291 KEDDEIAEEEAEELSI--------SETDEDDDLQENEDNKQHKESLKRVTFALPDDAETE 342
K I E LS S + D + +EDNK+ K+ ++
Sbjct: 1127 KRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQR-----------TSSK 1175
Query: 343 DTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLE 402
V+ +K + +++S +++Q I S +E GE ++ ++ + E
Sbjct: 1176 KKAVIVKEKKRNSLRTSTKRKQAD----ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTE 1231
Query: 403 ETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH 462
+ H E + + + D ++ + K+ E E K L+ D
Sbjct: 1232 NLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLE---EIKANLSSDE 1288
Query: 463 EKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDS------------LFLKL--- 507
+ S E ++ K N++ +EE V + DS L KL
Sbjct: 1289 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1348
Query: 508 DALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAA 567
D S KP + N ++ E+ ++ + EE+ E +T +
Sbjct: 1349 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGV--SEEVSESEDEQRPRTRS 1406
Query: 568 EKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGK 627
K A ++ +R K+ +KR +IK +E + +S ++ + + E+ ++ + +
Sbjct: 1407 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
Query: 628 ASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKR 671
K GK + K + D+++ + +A K E++++KR
Sbjct: 1467 NDDSKSPGKGR--KKIRKILK--DDKLRTETQNALKEEEERRKR 1506
Score = 46.6 bits (109), Expect = 8e-05
Identities = 142/733 (19%), Positives = 272/733 (37%), Gaps = 172/733 (23%)
Query: 96 SETIN-----DEDISLLPE----SEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDP 146
SET++ DE +++L E S + D +EI + K L DL+ + G DD
Sbjct: 722 SETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKT-LYDLKTQA----GKDDK 776
Query: 147 EMGERAENSSKSDL-------RKSPVFS-------DEDSDLDFDISKLEQQSKVQNK-GQ 191
+R ++S SD KS + S E S+ D S+LE++ K +K G
Sbjct: 777 GKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYD---SELEKEIKSMSKIGA 833
Query: 192 GKPREKSIVDDKFFKLSEMEAYLE---------NIEKEEERKDDNDEEEEDIDFFEDIDS 242
+ +K I + K F SE E + + N++ +E D+ E +++ + F +
Sbjct: 834 ARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEG 893
Query: 243 DEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDED-ITNVHDDELDSNKEDD------- 294
D+ + + K + D D + E T++ ++ KE
Sbjct: 894 TVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKT 953
Query: 295 ---------EIAEEEAEELSISETDEDDDLQENEDNKQHKE--SLKRVTFALPDDAETED 343
+IAE+ ++ ET EDD Q + ++ K+ K+ + E+
Sbjct: 954 CKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSS 1013
Query: 344 TG---------VLNVKKNSDEVKSSF---EKRQEKMNEKIASLEKEL------------- 378
G + + K ++K+ EK+ +K+ +K + + EL
Sbjct: 1014 DGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDS 1073
Query: 379 ---------------LEKKPWQLQGEVTAQKR-------PENSLLEETLHFDHAVRMAPV 416
EKK +L G+ + +++ + S+ E+ +
Sbjct: 1074 CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1133
Query: 417 ITEETTLQLEDIIKQRIRDQAWDDVVRK---EKPKEDAYEYKKRLTLDHEKSKLSLAEIY 473
+ E L + K+ + D K K+ KK+ + EK + SL
Sbjct: 1134 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTST 1193
Query: 474 EQEYIKLNQQKTAEEENPEHVEI-QKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPA 532
+++ + +++ E+ + I + D +K PV E V+S+
Sbjct: 1194 KRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK-------------PVTENLVLSSHTG 1240
Query: 533 I-------TMEEVAPVSVSD-----------AALLAPEEIK-----EKNKAGDIKTAAEK 569
+ + PV+V D A + EEIK +++ + D + K
Sbjct: 1241 FCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGK 1300
Query: 570 TATDKKRERRKKKYQKRMKI------------KEKEKRRKLLEKSSVD--QAGKYSKTVA 615
T K+ E + + ++ K + + R L K +V ++G+ KT
Sbjct: 1301 KRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1360
Query: 616 SEKLKQLTKTGKASFIKDEGKDKALKSS--QAFFSKLQDQVKMQINDAKKTE-------- 665
E K++ + ++ +D + S S+ +D+ + + AKK E
Sbjct: 1361 KEH-KEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSY 1419
Query: 666 KKKKKRQDISVHK 678
K+KKKR+ I V +
Sbjct: 1420 KQKKKRRRIKVQE 1432
Score = 43.1 bits (100), Expect = 8e-04
Identities = 79/403 (19%), Positives = 157/403 (38%), Gaps = 34/403 (8%)
Query: 109 ESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENS-SKSDLRKSPVFS 167
+S E ++ ++G+ + L + D + D E E+ + SD R +
Sbjct: 1075 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIEL 1134
Query: 168 DEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKL---SEMEAYLENIEKEEERK 224
E +L S ++Q+ E+S D+K K S+ +A + +K +
Sbjct: 1135 RERRNL----SSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLR 1190
Query: 225 DDNDEEEEDIDF-----FEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDI 279
++ DI ED D + G +K+K + L F DE +
Sbjct: 1191 TSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEAL 1250
Query: 280 TN----VHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFAL 335
+ DD+ D N ++ IA++ E + D+D +++ ++ K+ +
Sbjct: 1251 SKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEEN 1310
Query: 336 PDDAETEDTGVLNVKKNSDEVKSSFEK-RQEKMNEKIASLEKELLEKKPWQLQGEVTAQK 394
P D E ++ +N + +SD +S + R + K+ + E E+K + + +
Sbjct: 1311 PGDEEAKNQ--VNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKG 1368
Query: 395 RPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEY 454
R + E D + + V E + ED + R R +K + +E+ Y
Sbjct: 1369 RNRRKVSSEDSE-DSDFQESGV--SEEVSESEDEQRPRTRS------AKKAELEENQRSY 1419
Query: 455 K-----KRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPE 492
K +R+ + + S + + E+E K +++ EEE E
Sbjct: 1420 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1462
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 66.6 bits (161), Expect = 7e-11
Identities = 122/645 (18%), Positives = 262/645 (40%), Gaps = 90/645 (13%)
Query: 68 IENFDDEQIWQQLELQNEPILQYFQNAVSE------TINDEDISLLP---ESEEQEREED 118
+E D+ ++L + E + Q A+ TI D +SL +++ E E
Sbjct: 88 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 147
Query: 119 GSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDIS 178
E +++ +++ ++EE E + + AE + K D K +E+ I
Sbjct: 148 EKEEKSESRQERYEIEETETVTKSYQKNDWRD-AEENKKEDKEKEE--EEEEKPKRGSIG 204
Query: 179 KLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFE 238
+ + + V+ K E ++ K ++S E ++EEER+ +DE I E
Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP-----KQEEEREQGSDE----ISHHE 255
Query: 239 DIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAE 298
++ ++ E +L++ + R +++++D K DE A
Sbjct: 256 KMEEEDKERAEAERARLEAEERER----------IKAEQD-----------KKIADERAR 294
Query: 299 EEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKS 358
EAEE + ++ E +E E+ ++ +E KR E E ++ +E K
Sbjct: 295 IEAEEKAAAQERER---REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
Query: 359 SFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVIT 418
+ E+RQ E+ + E+ + + + +V QKR N LEE HA++ +
Sbjct: 352 AAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR--NKQLEEK---KHAMQETKIKG 406
Query: 419 EETTLQLEDII---KQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQ 475
E+ ++E K+ D+ V++K+ ++ KR L +K EI ++
Sbjct: 407 EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 466
Query: 476 EYIK-----------LNQQKTAEEENPEHVEIQ----KMMDSLFLKLDALSNFHFIPKPP 520
+ K ++++K E ++ E K ++ F + ++
Sbjct: 467 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 526
Query: 521 VPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKR---- 576
P+++ L + S E++K+K + ++ K +++R
Sbjct: 527 APQVEAGKRLEELRRRRGETESEEF------EKLKQKQQEAALELEELKKKREERRKVLE 580
Query: 577 --ERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDE 634
E+R+K+ + K++E+E++R+L E+ + + A+EK +++ + G + D+
Sbjct: 581 EEEQRRKQEEADRKLREEEEKRRLKEEI------ERRRAEAAEKRQKMPEDG----LSDD 630
Query: 635 GKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKL 679
K + + K++++ + +K+ K Q V K+
Sbjct: 631 KKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI 675
Score = 55.8 bits (133), Expect = 1e-07
Identities = 123/601 (20%), Positives = 245/601 (40%), Gaps = 91/601 (15%)
Query: 121 EIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKL 180
E+ +E++ LE E ++ NDD E E ++ + +E+S + ++
Sbjct: 9 ELRRQKREEMR-LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-----LGQV 62
Query: 181 EQQSKVQNKGQGKPRE-KSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEE--EEDIDFF 237
Q +V + E K+ + + + A+LE + + EER+ +E E +F
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 238 EDI--------------DSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVH 283
I D+ E+E + + + SR +Y+ +E E +T +
Sbjct: 123 PTITDASLSLPSRRMQNDTAENE-----TTEKEEKSESRQERYE-----IEETETVTKSY 172
Query: 284 DD----ELDSNKEDDEIAEEEAEEL----SISETDEDDDLQENEDNKQHKE---SLKRVT 332
+ + NK++D+ EEE EE SI E + ++E Q + SLK
Sbjct: 173 QKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQ 232
Query: 333 FALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTA 392
+ + + E+ ++ SDE+ EKM E+ +KE E + +L+ E
Sbjct: 233 ISSEEPKQEEER-----EQGSDEI-----SHHEKMEEE----DKERAEAERARLEAEERE 278
Query: 393 QKRPE--NSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKED 450
+ + E + +E + + A E + E+ ++R+R++ +++ KE+
Sbjct: 279 RIKAEQDKKIADERARIEAEEKAA--AQERERREAEE--RERMREEEKRAAEERQRIKEE 334
Query: 451 ---AYEYKKRLTLDHEKSKLSLAEIYEQE--YIKLNQQKTAEEENPEHVEIQKMMDSLFL 505
A E ++R+ + +++ I E+E + Q+ AEEE VE QK L
Sbjct: 335 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEE 394
Query: 506 KLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKT 565
K H + + + KV + + E + D A + + + K ++
Sbjct: 395 KK------HAMQETKIKGEKVEQKIEGKWVNE--KKAQEDKLQTAVLKKQGEEKGTKVQA 446
Query: 566 AAEKTATDK---KRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQL 622
EK DK K+E K + K+ K ++E + + K + + + KLK
Sbjct: 447 KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHT 506
Query: 623 TKT-----GKASFIKDEGKDKALKSSQAFFSKLQDQVKMQ--INDAKKTEKKKKKRQDIS 675
T G+AS E + + Q K ++++ + ++++ EK K+K+Q+ +
Sbjct: 507 ENTFSRPGGRASVDTKEAEG----APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAA 562
Query: 676 V 676
+
Sbjct: 563 L 563
Score = 50.4 bits (119), Expect = 5e-06
Identities = 87/415 (20%), Positives = 169/415 (40%), Gaps = 64/415 (15%)
Query: 300 EAEELSISETDEDDD----------LQENEDNKQHKESLKRVTFALPDDAETEDTGVLNV 349
EAE ++ D+D++ QE KQ +ESL +VT + +A+
Sbjct: 21 EAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP----- 75
Query: 350 KKNSDEVKSSFEKRQEKMNEKIASLEK--ELLEKKPWQLQGEVTAQKRPENSLLEETLHF 407
+E K++ Q + +++ A LE+ E++ +LQ + QK + ++ + +L
Sbjct: 76 ---DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSL 132
Query: 408 DHAVRMAPVITEETTLQLEDIIKQRIRDQAWD----DVVRKEKPKED---AYEYKK--RL 458
RM E T + E+ K R + ++ + V K K D A E KK +
Sbjct: 133 PSR-RMQNDTAENETTEKEE--KSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189
Query: 459 TLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHV----------EIQKMMDSLFLKLD 508
+ E+ K I E + + ++KT E + V E K + D
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSD 249
Query: 509 ALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIK---EKNKAGDIKT 565
+S H + + + + EE + +A E + E+ A +
Sbjct: 250 EIS--HHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE 307
Query: 566 AAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKT 625
E ++ RE K+ ++R +IKE+EK R E+ + + K A E+ +
Sbjct: 308 RREAEERERMREEEKRAAEERQRIKEEEK-RAAEERQRIKEE---EKRAAEERQR----- 358
Query: 626 GKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLK 680
IK+E K A + +A + +++ K ++ + K+ ++ ++K+ + K+K
Sbjct: 359 -----IKEEEKRAAEERQRA---RAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 66.2 bits (160), Expect = 9e-11
Identities = 91/447 (20%), Positives = 187/447 (41%), Gaps = 62/447 (13%)
Query: 73 DEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPE-------------SEEQEREEDG 119
D + W++ +++ F N E++ E S L + S+E+ +E+
Sbjct: 669 DREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEER 728
Query: 120 SEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS------DL 173
+I+ KE + EE++ D+ E E S+ + + E+S +
Sbjct: 729 DKIK---KESEKSFREEKIKDL----KEERENIPTDKDSEFTSLGMSAIEESIGLHLVEK 781
Query: 174 DFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEED 233
+ DI K E+ K + + KP ++S + +K + E + + EKE++ K ++ E++
Sbjct: 782 EIDIEKQEKHIK---ESKEKPEKRSQIKEKDIEKMERKTF----EKEKKIKHEHKSEKDK 834
Query: 234 IDFFEDIDSDEDEGGLFG---SKKLKSGKSSRNLK-YKDFFDPVESDEDITNVHDDELDS 289
+D E +D +++ L+ K K G+ S+N K D +S E + HD E
Sbjct: 835 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE--K 892
Query: 290 NKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNV 349
+++ +AE + + L + + D+ + ++ K + R + E + N
Sbjct: 893 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 952
Query: 350 KKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE--NSLLEETLHF 407
K +E KSS + +EK SL KE + +P + K+ + + E H
Sbjct: 953 KHIQEEKKSSIVDGNKAQHEKPLSL-KEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1011
Query: 408 DHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLD-----H 462
D +Q+ ++K ++ +A + +D +KRL D
Sbjct: 1012 D-------------KIQINSLLK--LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1056
Query: 463 EKSKLSLAEIYEQEYIKLNQQKTAEEE 489
+ LSL ++ +++ K +++K ++E
Sbjct: 1057 FERMLSLKDLEIEQWHKKHKEKIKQKE 1083
Score = 60.1 bits (144), Expect = 7e-09
Identities = 137/604 (22%), Positives = 244/604 (40%), Gaps = 110/604 (18%)
Query: 99 INDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKS 158
I DED S E+ + ++ E + K L+ E E+ + E + S
Sbjct: 601 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 660
Query: 159 DLRKSPVF-----------SDEDSDLDFDISK----LEQQSKVQN--KGQGKPREKSIVD 201
+L++S F SDE DL ++ LE++SK++ K +EK +
Sbjct: 661 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
Query: 202 DKFFKLSEMEAYLENIEKE--EERKDDNDEEEEDIDFFEDIDS--------DEDEGGLFG 251
++ FK E + + EK EE+ D EE E+I +D + +E G
Sbjct: 721 ERNFK-EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV 779
Query: 252 SKKLKSGKSSRNLKYKDFFDPVES---DEDITNVHDDELDSNKEDDEIAEEEAEELSISE 308
K++ K +++K S ++DI + + K+ + E ++L +SE
Sbjct: 780 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839
Query: 309 T----DEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQ 364
E D L + K HKE K A +KK D KS EK
Sbjct: 840 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA-------------IKKTDDREKSR-EKMD 885
Query: 365 EKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQ 424
K +++ E+ L E K L + K+ +NS ++ + +E +
Sbjct: 886 RKHDKEKPEKERHLAESKEKHLMEK--KNKQSDNSEYSKSEKGKN---------KEKDRE 934
Query: 425 LEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSK----LSLAEIYEQEYIKL 480
L+ K++ RD+ ++ + +E+ KK +D K++ LSL E + E +K
Sbjct: 935 LDK--KEKSRDKESINITNSKHIQEE----KKSSIVDGNKAQHEKPLSLKEKTKDEPLKT 988
Query: 481 NQQKTAEEENPE---HVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEE 537
K ++++ + + E K D + ++++L P P+ S ++
Sbjct: 989 PDGKEKDKKDKDIDRYKERDKHKDKI--QINSLLKLKSEADKPKPKSSPAS-------KD 1039
Query: 538 VAPVSVSDAALLAPEEIKEKNKAGD--IKTAAEKTAT--DKKRERRKKKYQKRMKIKEKE 593
P KEK D ++T+ E+ + D + E+ KK+++++K KEKE
Sbjct: 1040 TRP--------------KEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1085
Query: 594 --KRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKD------EGKDKALKSSQA 645
+ R LE D+ K T K K+LT++ K+S + D + KD SQ+
Sbjct: 1086 RLRNRNCLELKIKDKE-KTKHTPTESKNKELTRS-KSSEVTDAYTKEKQPKDAVSNRSQS 1143
Query: 646 FFSK 649
+K
Sbjct: 1144 VDTK 1147
Score = 50.4 bits (119), Expect = 5e-06
Identities = 110/557 (19%), Positives = 215/557 (38%), Gaps = 134/557 (24%)
Query: 147 EMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFK 206
E GE++ N+ D SP F + D L K++++ K K + K +E+
Sbjct: 592 EFGEKS-NAKIKDEDHSPTFENSDCTL----KKMDKEGKTLKKHKLKHKER--------- 637
Query: 207 LSEMEAYLENIEKEEER---KDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRN 263
E E + + IE E+E+ KD E + ++F D + + F S + +
Sbjct: 638 --EKEKHKKEIEGEKEKYKTKDSAKELQRSVEF----DREFWKENFFKSDETE------- 684
Query: 264 LKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQ 323
D F +E E +T +L+ N +DD+ +E+ + +E D +++ +
Sbjct: 685 ----DLFLNMEH-ESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSF 739
Query: 324 HKESLKRVTFA---LPDDAETEDTGV-----------------LNVKKNSDEVKSSFEKR 363
+E +K + +P D ++E T + ++++K +K S EK
Sbjct: 740 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 799
Query: 364 QEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTL 423
+++ K +EK +E+K ++ + ++ + + E L+ +
Sbjct: 800 EKRSQIKEKDIEK--MERKTFEKEKKIKHEHKSEKDKLDLS------------------- 838
Query: 424 QLEDIIKQRIRDQAWDDVVRK-----EKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYI 478
E + K + +D+ + K EK K A K T D EKS+ + +++E
Sbjct: 839 --ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK---TDDREKSREKMDRKHDKE-- 891
Query: 479 KLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEV 538
K +++ E +H+ +K S N + + E
Sbjct: 892 KPEKERHLAESKEKHLMEKKNKQS--------DNSEY------------------SKSEK 925
Query: 539 APVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKR----ERRKKKYQKRMKIKEKEK 594
D L E+ ++K I K ++K+ + K +++K + +KEK K
Sbjct: 926 GKNKEKDRELDKKEKSRDKES---INITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTK 982
Query: 595 RRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQV 654
L + D K K ++ K+ +D+ KDK +S D+
Sbjct: 983 DEPL---KTPDGKEKDKKDKDIDRYKE----------RDKHKDKIQINSLLKLKSEADKP 1029
Query: 655 KMQINDAKKTEKKKKKR 671
K + + A K + K+KR
Sbjct: 1030 KPKSSPASKDTRPKEKR 1046
Score = 48.9 bits (115), Expect = 2e-05
Identities = 110/498 (22%), Positives = 194/498 (38%), Gaps = 61/498 (12%)
Query: 201 DDKFFKLSEMEAYLENIEKEEERKDDNDE--EEEDIDFFEDIDSDEDEGGLFGSKKL-KS 257
+ +F S ++ EK + +KD + E E+ + ++ S E KK+ K
Sbjct: 564 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 623
Query: 258 GKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSIS---------- 307
GK+ + K K E H E++ KE + ++ A+EL S
Sbjct: 624 GKTLKKHKLKH-------KEREKEKHKKEIEGEKEKYK-TKDSAKELQRSVEFDREFWKE 675
Query: 308 ---ETDEDDDLQENEDNKQHK-ESLKRVTFALPDDAETEDTGVL---NVKKNSDEVKSSF 360
++DE +DL N +++ E ++ + DD T++ V N K+ D++K
Sbjct: 676 NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKES 735
Query: 361 EKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEE 420
EK + EKI L++E E P E T+ S +EE++ H V I ++
Sbjct: 736 EKSFRE--EKIKDLKEER-ENIPTDKDSEFTSLGM---SAIEESIGL-HLVEKEIDIEKQ 788
Query: 421 TTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH--EKSKLSLAEIYEQ--E 476
E K R Q + + EK + +E +K++ +H EK KL L+E ++ E
Sbjct: 789 EKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE 846
Query: 477 YIKLNQQKTA----EEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPA 532
KL T E E ++ K D + + H KP
Sbjct: 847 KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP------------- 893
Query: 533 ITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEK 592
E+ ++ S L ++ K+ + + K+ K + +K+K + + I
Sbjct: 894 ---EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINIT 950
Query: 593 EKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQD 652
+ EK S G ++ LK+ TK + KDK K + + +
Sbjct: 951 NSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKH 1010
Query: 653 QVKMQINDAKKTEKKKKK 670
+ K+QIN K + + K
Sbjct: 1011 KDKIQINSLLKLKSEADK 1028
Score = 48.5 bits (114), Expect = 2e-05
Identities = 98/497 (19%), Positives = 202/497 (40%), Gaps = 43/497 (8%)
Query: 192 GKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDID---------FFEDIDS 242
G P + + ++ ++E E LE + K E D+DE D + E+IDS
Sbjct: 252 GNPFQANKHGERPVDVAETEE-LELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 310
Query: 243 DEDEGGLF-GSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEA 301
+ ++ L SK++ K+ ++ + DE+I + DD KE + E EA
Sbjct: 311 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 370
Query: 302 EELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFE 361
E+ + E ++ +K+ K S RV ++ + ++ E + + + +
Sbjct: 371 EKTHLFAKQEKAFYPKSFKSKKQKPS--RVLYSSTESSDEEALQNKKISTSCSVIPETSN 428
Query: 362 KRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEET 421
+ E + S E + K +L+ + K EN L++ R+ +T T
Sbjct: 429 SDMQTKKEYVVSGEHKQKGKVKRKLKNQ---NKNKENQELKQEKEGKENTRITN-LTVNT 484
Query: 422 TLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLN 481
L + ++ + + PK+D + ++ KS + E++ L
Sbjct: 485 GLDCSEKTREE------GNFRKSFSPKDDTSLHLFHISTG--KSPKHSCGLSEKQSTPLK 536
Query: 482 QQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPV 541
Q+ T +P E+ D ++ D + F+P+ S++ + +E +
Sbjct: 537 QEHTKTCLSPGSSEMSLQPD--LVRYDNTES-EFLPES--------SSVKSCKHKEKSKH 585
Query: 542 SVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEK 601
D L E+ K K D E + K+ ++ K K+ K+K KE+ ++ +K
Sbjct: 586 Q-KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKK 644
Query: 602 SSVDQAGKYSKTVASEKLKQLTKTG----KASFIK-DEGKDKALK-SSQAFFSKLQDQVK 655
+ KY ++++L++ + K +F K DE +D L ++ + + +++
Sbjct: 645 EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLE 704
Query: 656 MQINDAKKTEKKKKKRQ 672
I D K T++K ++
Sbjct: 705 KNIKDDKSTKEKHVSKE 721
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 66.2 bits (160), Expect = 9e-11
Identities = 91/447 (20%), Positives = 187/447 (41%), Gaps = 62/447 (13%)
Query: 73 DEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPE-------------SEEQEREEDG 119
D + W++ +++ F N E++ E S L + S+E+ +E+
Sbjct: 692 DREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEER 751
Query: 120 SEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDS------DL 173
+I+ KE + EE++ D+ E E S+ + + E+S +
Sbjct: 752 DKIK---KESEKSFREEKIKDL----KEERENIPTDKDSEFTSLGMSAIEESIGLHLVEK 804
Query: 174 DFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEED 233
+ DI K E+ K + + KP ++S + +K + E + + EKE++ K ++ E++
Sbjct: 805 EIDIEKQEKHIK---ESKEKPEKRSQIKEKDIEKMERKTF----EKEKKIKHEHKSEKDK 857
Query: 234 IDFFEDIDSDEDEGGLFG---SKKLKSGKSSRNLK-YKDFFDPVESDEDITNVHDDELDS 289
+D E +D +++ L+ K K G+ S+N K D +S E + HD E
Sbjct: 858 LDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKE--K 915
Query: 290 NKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNV 349
+++ +AE + + L + + D+ + ++ K + R + E + N
Sbjct: 916 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 975
Query: 350 KKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPE--NSLLEETLHF 407
K +E KSS + +EK SL KE + +P + K+ + + E H
Sbjct: 976 KHIQEEKKSSIVDGNKAQHEKPLSL-KEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1034
Query: 408 DHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLD-----H 462
D +Q+ ++K ++ +A + +D +KRL D
Sbjct: 1035 D-------------KIQINSLLK--LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1079
Query: 463 EKSKLSLAEIYEQEYIKLNQQKTAEEE 489
+ LSL ++ +++ K +++K ++E
Sbjct: 1080 FERMLSLKDLEIEQWHKKHKEKIKQKE 1106
Score = 60.1 bits (144), Expect = 7e-09
Identities = 137/604 (22%), Positives = 244/604 (40%), Gaps = 110/604 (18%)
Query: 99 INDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKS 158
I DED S E+ + ++ E + K L+ E E+ + E + S
Sbjct: 624 IKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK 683
Query: 159 DLRKSPVF-----------SDEDSDLDFDISK----LEQQSKVQN--KGQGKPREKSIVD 201
+L++S F SDE DL ++ LE++SK++ K +EK +
Sbjct: 684 ELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 743
Query: 202 DKFFKLSEMEAYLENIEKE--EERKDDNDEEEEDIDFFEDIDS--------DEDEGGLFG 251
++ FK E + + EK EE+ D EE E+I +D + +E G
Sbjct: 744 ERNFK-EERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV 802
Query: 252 SKKLKSGKSSRNLKYKDFFDPVES---DEDITNVHDDELDSNKEDDEIAEEEAEELSISE 308
K++ K +++K S ++DI + + K+ + E ++L +SE
Sbjct: 803 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 862
Query: 309 T----DEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQ 364
E D L + K HKE K A +KK D KS EK
Sbjct: 863 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAA-------------IKKTDDREKSR-EKMD 908
Query: 365 EKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQ 424
K +++ E+ L E K L + K+ +NS ++ + +E +
Sbjct: 909 RKHDKEKPEKERHLAESKEKHLMEK--KNKQSDNSEYSKSEKGKN---------KEKDRE 957
Query: 425 LEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSK----LSLAEIYEQEYIKL 480
L+ K++ RD+ ++ + +E+ KK +D K++ LSL E + E +K
Sbjct: 958 LDK--KEKSRDKESINITNSKHIQEE----KKSSIVDGNKAQHEKPLSLKEKTKDEPLKT 1011
Query: 481 NQQKTAEEENPE---HVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEE 537
K ++++ + + E K D + ++++L P P+ S ++
Sbjct: 1012 PDGKEKDKKDKDIDRYKERDKHKDKI--QINSLLKLKSEADKPKPKSSPAS-------KD 1062
Query: 538 VAPVSVSDAALLAPEEIKEKNKAGD--IKTAAEKTAT--DKKRERRKKKYQKRMKIKEKE 593
P KEK D ++T+ E+ + D + E+ KK+++++K KEKE
Sbjct: 1063 TRP--------------KEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKE 1108
Query: 594 --KRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKD------EGKDKALKSSQA 645
+ R LE D+ K T K K+LT++ K+S + D + KD SQ+
Sbjct: 1109 RLRNRNCLELKIKDKE-KTKHTPTESKNKELTRS-KSSEVTDAYTKEKQPKDAVSNRSQS 1166
Query: 646 FFSK 649
+K
Sbjct: 1167 VDTK 1170
Score = 50.4 bits (119), Expect = 5e-06
Identities = 110/557 (19%), Positives = 215/557 (38%), Gaps = 134/557 (24%)
Query: 147 EMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFK 206
E GE++ N+ D SP F + D L K++++ K K + K +E+
Sbjct: 615 EFGEKS-NAKIKDEDHSPTFENSDCTL----KKMDKEGKTLKKHKLKHKER--------- 660
Query: 207 LSEMEAYLENIEKEEER---KDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRN 263
E E + + IE E+E+ KD E + ++F D + + F S + +
Sbjct: 661 --EKEKHKKEIEGEKEKYKTKDSAKELQRSVEF----DREFWKENFFKSDETE------- 707
Query: 264 LKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQ 323
D F +E E +T +L+ N +DD+ +E+ + +E D +++ +
Sbjct: 708 ----DLFLNMEH-ESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSF 762
Query: 324 HKESLKRVTFA---LPDDAETEDTGV-----------------LNVKKNSDEVKSSFEKR 363
+E +K + +P D ++E T + ++++K +K S EK
Sbjct: 763 REEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKP 822
Query: 364 QEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTL 423
+++ K +EK +E+K ++ + ++ + + E L+ +
Sbjct: 823 EKRSQIKEKDIEK--MERKTFEKEKKIKHEHKSEKDKLDLS------------------- 861
Query: 424 QLEDIIKQRIRDQAWDDVVRK-----EKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYI 478
E + K + +D+ + K EK K A K T D EKS+ + +++E
Sbjct: 862 --ECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKK---TDDREKSREKMDRKHDKE-- 914
Query: 479 KLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEV 538
K +++ E +H+ +K S N + + E
Sbjct: 915 KPEKERHLAESKEKHLMEKKNKQS--------DNSEY------------------SKSEK 948
Query: 539 APVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKR----ERRKKKYQKRMKIKEKEK 594
D L E+ ++K I K ++K+ + K +++K + +KEK K
Sbjct: 949 GKNKEKDRELDKKEKSRDKES---INITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTK 1005
Query: 595 RRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQV 654
L + D K K ++ K+ +D+ KDK +S D+
Sbjct: 1006 DEPL---KTPDGKEKDKKDKDIDRYKE----------RDKHKDKIQINSLLKLKSEADKP 1052
Query: 655 KMQINDAKKTEKKKKKR 671
K + + A K + K+KR
Sbjct: 1053 KPKSSPASKDTRPKEKR 1069
Score = 48.9 bits (115), Expect = 2e-05
Identities = 110/498 (22%), Positives = 194/498 (38%), Gaps = 61/498 (12%)
Query: 201 DDKFFKLSEMEAYLENIEKEEERKDDNDE--EEEDIDFFEDIDSDEDEGGLFGSKKL-KS 257
+ +F S ++ EK + +KD + E E+ + ++ S E KK+ K
Sbjct: 587 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 646
Query: 258 GKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSIS---------- 307
GK+ + K K E H E++ KE + ++ A+EL S
Sbjct: 647 GKTLKKHKLKH-------KEREKEKHKKEIEGEKEKYK-TKDSAKELQRSVEFDREFWKE 698
Query: 308 ---ETDEDDDLQENEDNKQHK-ESLKRVTFALPDDAETEDTGVL---NVKKNSDEVKSSF 360
++DE +DL N +++ E ++ + DD T++ V N K+ D++K
Sbjct: 699 NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKES 758
Query: 361 EKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEE 420
EK + EKI L++E E P E T+ S +EE++ H V I ++
Sbjct: 759 EKSFRE--EKIKDLKEER-ENIPTDKDSEFTSLGM---SAIEESIGL-HLVEKEIDIEKQ 811
Query: 421 TTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDH--EKSKLSLAEIYEQ--E 476
E K R Q + + EK + +E +K++ +H EK KL L+E ++ E
Sbjct: 812 EKHIKESKEKPEKRSQIKEKDI--EKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE 869
Query: 477 YIKLNQQKTA----EEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPA 532
KL T E E ++ K D + + H KP
Sbjct: 870 KDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKP------------- 916
Query: 533 ITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEK 592
E+ ++ S L ++ K+ + + K+ K + +K+K + + I
Sbjct: 917 ---EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINIT 973
Query: 593 EKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQD 652
+ EK S G ++ LK+ TK + KDK K + + +
Sbjct: 974 NSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKH 1033
Query: 653 QVKMQINDAKKTEKKKKK 670
+ K+QIN K + + K
Sbjct: 1034 KDKIQINSLLKLKSEADK 1051
Score = 48.5 bits (114), Expect = 2e-05
Identities = 98/497 (19%), Positives = 202/497 (40%), Gaps = 43/497 (8%)
Query: 192 GKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDID---------FFEDIDS 242
G P + + ++ ++E E LE + K E D+DE D + E+IDS
Sbjct: 275 GNPFQANKHGERPVDVAETEE-LELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS 333
Query: 243 DEDEGGLF-GSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEA 301
+ ++ L SK++ K+ ++ + DE+I + DD KE + E EA
Sbjct: 334 ETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPEA 393
Query: 302 EELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFE 361
E+ + E ++ +K+ K S RV ++ + ++ E + + + +
Sbjct: 394 EKTHLFAKQEKAFYPKSFKSKKQKPS--RVLYSSTESSDEEALQNKKISTSCSVIPETSN 451
Query: 362 KRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEET 421
+ E + S E + K +L+ + K EN L++ R+ +T T
Sbjct: 452 SDMQTKKEYVVSGEHKQKGKVKRKLKNQ---NKNKENQELKQEKEGKENTRITN-LTVNT 507
Query: 422 TLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLN 481
L + ++ + + PK+D + ++ KS + E++ L
Sbjct: 508 GLDCSEKTREE------GNFRKSFSPKDDTSLHLFHISTG--KSPKHSCGLSEKQSTPLK 559
Query: 482 QQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPV 541
Q+ T +P E+ D ++ D + F+P+ S++ + +E +
Sbjct: 560 QEHTKTCLSPGSSEMSLQPD--LVRYDNTES-EFLPES--------SSVKSCKHKEKSKH 608
Query: 542 SVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEK 601
D L E+ K K D E + K+ ++ K K+ K+K KE+ ++ +K
Sbjct: 609 Q-KDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKK 667
Query: 602 SSVDQAGKYSKTVASEKLKQLTKTG----KASFIK-DEGKDKALK-SSQAFFSKLQDQVK 655
+ KY ++++L++ + K +F K DE +D L ++ + + +++
Sbjct: 668 EIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLE 727
Query: 656 MQINDAKKTEKKKKKRQ 672
I D K T++K ++
Sbjct: 728 KNIKDDKSTKEKHVSKE 744
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 64.7 bits (156), Expect = 3e-10
Identities = 100/582 (17%), Positives = 238/582 (40%), Gaps = 48/582 (8%)
Query: 101 DEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKS-- 158
++++ L E E+ +R E +++ ++ ED E + D + E +
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 159 DLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIE 218
L P ++ L + L+++ + + + + R + + ++ + +++ E +
Sbjct: 888 TLYAKPALQEQ---LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 219 KEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDED 278
+EE K E E + +D + E L G + K + R KY++ + + +E
Sbjct: 945 REEREKRRRQERERQ--YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 279 ITNVHDDELDSN------KEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVT 332
+ ++ ++ DE+ +EE E + E E LQE E + +E L++
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEE--EQLLREEREKRRLQERERQYREEEELQQ-- 1058
Query: 333 FALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTA 392
E + G + E++ + K +E E E++LL ++P + +
Sbjct: 1059 ------EEEQLLGEERETRRRQELERQYRKEEELQQE-----EEQLLREEPEKRR----R 1103
Query: 393 QKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAY 452
Q+R EE L + + + +LE ++ Q ++ + +E+P++
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 453 EYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSN 512
+ +R + E+ + ++ +E K Q++ + E ++ QK + D S+
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR-YRDEDQRSD 1222
Query: 513 FHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIK-TAAEKTA 571
+ P E V N E L +++++ D++ E+
Sbjct: 1223 LKW-QWEPEKENAVRDNKVYCKGRE-----NEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276
Query: 572 TDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFI 631
D+++ERR+ + + R +E++ LE+ +A + + S++ KQL + +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQ-----LEREEQKEAKRRDR--KSQEEKQLLREEREEKR 1329
Query: 632 KDEGKDKALKSSQAFFSKLQDQ-VKMQINDAKKTEKKKKKRQ 672
+ + D+ + + + ++Q ++ Q D K E++ + ++
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371
Score = 63.9 bits (154), Expect = 5e-10
Identities = 114/602 (18%), Positives = 253/602 (42%), Gaps = 70/602 (11%)
Query: 111 EEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDED 170
EE+ DG E D+ ED E D ++ E G+R + R
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEE-EPGQRRRQKRQEQER--------- 146
Query: 171 SDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEE 230
++++ E+QS+ Q + + + R++ D++ ++ + E E+EE R E
Sbjct: 147 -----ELAEGEEQSEKQERLEQRDRQRR--DEELWRQRQ-----EWQEREERRA-----E 189
Query: 231 EEDIDFFEDIDSDE--DEGGLFGSKKL---KSGKSSRNLKYKDFFDPVESDEDITNVHDD 285
EE + + +++E DE L + L + G+ + + ++ D V +E+
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 286 ELDSNKEDDEIAEEEA--------EELSISETDEDDDLQENEDNKQHKESLKRVTFALPD 337
E KE++++ EEE EE + + + + +E ++ +Q ++ L+R L
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRR 308
Query: 338 DAETEDTGVLNVKKNSDEVKSSFEKRQEKM--NEKIASLEKELL-----EKKPWQLQGEV 390
E E ++ E + E+R+E+ E+ E++L E++ QL+ E
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 391 TAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKED 450
++R + E+ L + +R + E L+ E +++ + + + R+++ + +
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 451 AYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDS------LF 504
E + + E+ + L E+ L +++ E E + Q D +
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 505 LKLDALSNFHFIPKPPVP-----EIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNK 559
LKL+ + E + L EE + L E+ E+ +
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ--EERR 546
Query: 560 AGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKL 619
+K EK ++RE+R K+ +++E+R +LL++ ++ + K E+L
Sbjct: 547 EQLLKREEEKRLEQERREQRLKR-------EQEERRDQLLKREE-ERRQQRLKREQEERL 598
Query: 620 KQLTKTGKASFI-KDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHK 678
+Q K + + ++E +++ LK + + Q +K + + ++ ++ ++++Q+ +
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 679 LK 680
LK
Sbjct: 659 LK 660
Score = 58.9 bits (141), Expect = 1e-08
Identities = 105/630 (16%), Positives = 249/630 (39%), Gaps = 61/630 (9%)
Query: 69 ENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKE 128
+ + DE L+ Q EP + + D + EQ R+ + S++ D++
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKE-------NAVRDNKVYCKGRENEQFRQLEDSQLR--DRQ 1262
Query: 129 DLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQN 188
+DL+ D + R + + + + +E + K +++ ++
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 189 KGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGG 248
+ + + R + D KF E E L+ E++ R+ + D + F E+ +++G
Sbjct: 1323 EEREEKRRRQETDRKF---REEEQLLQEREEQPLRRQERDRK-----FREEELRHQEQGR 1374
Query: 249 LFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISE 308
F ++ + + R K+ +E + E ++ D EE ++LS E
Sbjct: 1375 KFLEEEQRLRRQERERKFL-------KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Query: 309 TDEDDDLQENEDNKQHKE-SLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKM 367
D +E + +Q +E L + + + + +E + ++R K
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487
Query: 368 NEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLED 427
E+ L ++ ++K + + + PE LEE R + EE L+ ++
Sbjct: 1488 LEEEQQLRRQERDRK---FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 428 IIKQRIRDQ----AWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQ 483
+QR +D+ ++ +R+E+ ++ ++ E+ K+ E E+++++ QQ
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE-QERKFMEDEQQ 1603
Query: 484 KTAEEENPEHVEIQKMMDSLFLKLDAL------SNFH-------FIPKPPVPEIKVVSNL 530
+E + +++ D F + + L H F+ + P +++
Sbjct: 1604 LRRQEGQQQ---LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP--QLRRQERE 1658
Query: 531 PAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRK--------KK 582
+ + + L EE + + + D K E+ ++ RK ++
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 583 YQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKS 642
+ K +E+E+ R+ E+ + + +Y K + E+L+ + + + E K +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR--PEREEQQLRRQERDRKFREE 1776
Query: 643 SQAFFSKLQDQVKMQINDAKKTEKKKKKRQ 672
Q + + Q++ Q +D K E+++ +++
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Score = 56.2 bits (134), Expect = 1e-07
Identities = 98/608 (16%), Positives = 239/608 (39%), Gaps = 44/608 (7%)
Query: 73 DEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREE------DGSEIEADD 126
DE++W+Q + E + + ++ + P+ E+ R E G E +
Sbjct: 170 DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQ 229
Query: 127 KEDLED--LEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQS 184
+ + +D +EEE + + + + E + + ++ +E+ L KLE+Q
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL----RKLERQE 285
Query: 185 KVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDE 244
+ + + + +++ + ++ + + E E E++EER++ + E+ + E E
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEE---ERREQQEERREQQERREQQEERREQQLRRE 342
Query: 245 DEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEEL 304
E + + + R + + E +E+ + + ++ E+ +L
Sbjct: 343 QEERREQQLRREQEEERREQQLRR-----EQEEERREQQLRREQQLRREQQLRREQ--QL 395
Query: 305 SISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQ 364
+ + E + ++ L+R + E ++ +K E+R+
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 365 EKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQ 424
+ + + E+ E++ QL+ + ++R LEE + R + E +
Sbjct: 456 DWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 425 LEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQK 484
E +K++ ++ +R E+ E ++ L E+ K EQE + ++
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR-----LEQERREQRLKR 569
Query: 485 TAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVS 544
EE + ++ ++ LK + K E ++ P
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 545 DAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSV 604
LL EE +E+ + + E+ KRE +++ ++R+K + +E+RR+
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE------- 682
Query: 605 DQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKT 664
+ +A E+ +Q + K+ K + + ++ + A SK+ + + Q ++
Sbjct: 683 -------QELAEEEQEQARERIKSRIPKWQWQLES--EADARQSKVYSRPRKQEGQRRRQ 733
Query: 665 EKKKKKRQ 672
E+++K+R+
Sbjct: 734 EQEEKRRR 741
Score = 56.2 bits (134), Expect = 1e-07
Identities = 97/580 (16%), Positives = 231/580 (39%), Gaps = 64/580 (11%)
Query: 97 ETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSS 156
E + E+ LL E E+ R ++ E + K++L+ EE+ + R E
Sbjct: 994 EELQQEEEQLLREEREKRRRQEW-ERQYRKKDELQQEEEQLL------------REEREK 1040
Query: 157 KSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLEN 216
+ + + +E+ +L+Q+ + + + R + ++ ++ K E++ E
Sbjct: 1041 RRLQERERQYREEE--------ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 217 IEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESD 276
+ +EE K E E E++ +E++ L ++ K + +Y++ + + +
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQ--LLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 277 EDITNVHDD-----ELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRV 331
E + + EL+ ++E ++E E+L E ++ +E + ++ + ++
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 332 TFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVT 391
D+ + D + + V+ + + + NE+ LE L + Q +
Sbjct: 1211 KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL 1270
Query: 392 AQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDA 451
++ E +E + R P EE L+ E+ + + RD+ + K+ +E+
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFP---EEEQLEREEQKEAKRRDRKSQE--EKQLLREER 1325
Query: 452 YEYKKRLTLDHE--KSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDA 509
E ++R D + + + L E EQ + + + EE H E +
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR----------- 1374
Query: 510 LSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEK 569
K + + +E + + L +E +++ + + E+
Sbjct: 1375 ---------------KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419
Query: 570 TATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKAS 629
++ER +K ++ +++ +E+ RK LE+ + ++ K E+L L + +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL--LQEREEQQ 1477
Query: 630 FIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKK 669
+ E K L+ Q + +D+ K + + + E ++K
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDR-KFREQELRSQEPERK 1516
Score = 51.2 bits (121), Expect = 3e-06
Identities = 109/617 (17%), Positives = 250/617 (40%), Gaps = 57/617 (9%)
Query: 63 LQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEI 122
L++ +E + E+ +Q + EP + Q + +E E+QER E +
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 123 EADDKEDLEDLEEEEVSDMGNDD--PEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKL 180
E +++ + L+ E + + E E+A KS + K + ++D
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD-------- 713
Query: 181 EQQSKVQN---KGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFF 237
+QSKV + K +G+ R + + + + SE++ ++EE EEE+ DF
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ-----WQEEERAHRQQQEEEQRRDFT 768
Query: 238 EDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIA 297
++E KS + + L + P ++ + +E ++
Sbjct: 769 WQWQAEE-----------KSERGRQRLSAR----PPLREQRERQLRAEERQQREQRFLPE 813
Query: 298 EEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVK 357
EEE E+ + + +LQ E+ +Q + + +D ED ++ + K
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 358 SSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVI 417
++ +E+ + K L++ QL+ E + E L E
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQE---QLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 418 TEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEY 477
EE LQ E+ +Q +R++ K + +E +Y+K L ++ +L L E E+
Sbjct: 931 REEEQLQQEE--EQLLREER-----EKRRRQERERQYRKDKKLQQKEEQL-LGEEPEKRR 982
Query: 478 IKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEE 537
+ ++K EEE + E Q + + + + K E++ E
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK---DELQQEEEQLLREERE 1039
Query: 538 VAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRK 597
+ + EE++++ + + E+ T ++R+ +++Y+K +++++E++
Sbjct: 1040 KRRLQERERQYREEEELQQEEE----QLLGEERET-RRRQELERQYRKEEELQQEEEQLL 1094
Query: 598 LLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQ 657
E + + + E+L+Q + +++E + + + + + + +++V+ +
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQ----EEEQLLREEREKRRRQELERQYRE-EEEVQQE 1149
Query: 658 INDAKKTEKKKKKRQDI 674
+ E +K++RQ++
Sbjct: 1150 EEQLLREEPEKRRRQEL 1166
Score = 48.5 bits (114), Expect = 2e-05
Identities = 95/529 (17%), Positives = 212/529 (40%), Gaps = 94/529 (17%)
Query: 109 ESEEQEREEDGSEIEADDKEDLEDL----EEEEVSDMGNDDPEMGERAENSSKSDLRKSP 164
ESE Q +EE+ + + ++E D + EE S+ G R S++ LR+
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG--------RQRLSARPPLRE-- 792
Query: 165 VFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERK 224
+ E+Q + + + Q + R +L E++E+R+
Sbjct: 793 --------------QRERQLRAEERQQREQR-----------------FLPEEEEKEQRR 821
Query: 225 DDNDEEEEDIDFFEDID-----------SDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPV 273
E E+++ F E+ + +E++G ++ +S + R+ K++ +
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 274 ESDEDITNVHDDELDSN-KEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVT 332
T L +++ ++ +EE EEL + +E + + E +Q++E
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL---QREEREKRRRQEQERQYREE----- 933
Query: 333 FALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTA 392
+ + E+ +L ++ ++ + +RQ + ++K+ E++LL ++P + + +
Sbjct: 934 ----EQLQQEEEQLL--REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 393 QKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAY 452
+K E L++ EE L E+ +++ R Q W+ RK+ E
Sbjct: 988 KKYREEEELQQ---------------EEEQLLREE--REKRRRQEWERQYRKK--DELQQ 1028
Query: 453 EYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSN 512
E ++ L + EK +L E +E +L Q++ ++ ++ + K + L
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 513 FHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTAT 572
PE + EE + + LL E K + + + + E+
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 573 DKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQ 621
++ + +++ +KR + +E R+ E+ + Q + EK +Q
Sbjct: 1148 QEEEQLLREEPEKR---RRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Score = 42.4 bits (98), Expect = 0.001
Identities = 91/582 (15%), Positives = 231/582 (39%), Gaps = 71/582 (12%)
Query: 54 ENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQ 113
E GR Q+L + + + + ++ +L+ + Q + +E+ L + ++
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 114 EREEDGSEIEADDKE-----DLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSD 168
+ E+ ++ ++E + + L +E ++ + ER E R +
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 169 EDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFF-------KLSEMEAYLENIEKEE 221
E + +++ + Q +P K + +++ K + E L E+ +
Sbjct: 1491 EQQ---LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 222 ERKDDNDE---EEEDI--DFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESD 276
+R+ D D EEE + + E S ++ F ++ K + + K+ + +
Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ 1607
Query: 277 EDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALP 336
E + + +ED+++ +E EE + + D E E + +E ++ L
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERDRKFLEEEPQLRRQEREQQ----LR 1662
Query: 337 DDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRP 396
D + + + + +E + ++R K E+ L ++ E+K Q + ++ Q+
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 397 ENSLLEETLHFDHAVRMAPVITEETTLQLED-----IIKQRIRDQAWDDVVRKEKPKEDA 451
EE L + TE+ L+ ++ + ++++R + + +R+++ ++
Sbjct: 1723 RKFREEEQLRQE---------TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE-RDRK 1772
Query: 452 YEYKKRLTLDHEKSKLSLAEIYEQ--EYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDA 509
+ +++L + E+ +L E + E +L Q++ ++ P+ + + + L+L+
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 510 LSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEK 569
+E D A E+ + K+ + +
Sbjct: 1833 --------------------------QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866
Query: 570 TATDKKRERRKKKYQK---RMKIKEKEKRRKLLEKSSVDQAG 608
K+R+ R++K ++ R + KE+++ R++ E S + G
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 63.5 bits (153), Expect = 6e-10
Identities = 128/610 (20%), Positives = 243/610 (39%), Gaps = 46/610 (7%)
Query: 80 LELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVS 139
+++++E ++ + + ET+ E+ + + E+ EE+ E + ++ ++ E EEEE +
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEE-A 494
Query: 140 DMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSI 199
+ G ++ + E +S KSPV + S + +K ++ + ++ + K EK+
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE---AKSPEKEEAKSPAEVKSPEKAK 551
Query: 200 VDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGK 259
K S EA E+ + + E+ E+ S + KS +
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE---------AKSPE 602
Query: 260 SSRNLKYKDFFDPVESDEDITNVHDD--ELDSNKEDDEIAEEEAEELSISETDEDDDLQE 317
+++ ++ P E+ + E+ S ++ +EEA+ +++ E ++ +
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 318 NEDNKQ----HKESLKRVTFALPDDAETEDTGVLNVKK--NSDEVKSSFEKRQEKMNEKI 371
E K +S ++ + +A++ + VK+ S E S K + K EK
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 372 ASLEKELLEKKPWQLQGEVTAQ-KRPENSLL-EETLHFDHAVRMAPVITEETTLQLEDII 429
S KE K P + + V + K PE + E+ D A +E D
Sbjct: 723 KSPVKE-EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF 781
Query: 430 KQRIRDQAWDDVVRKEKP----KEDAYEYKKRLTLDHE-KSKLSLAEIYEQEYIKLNQQK 484
++ + ++V EK KEDA +K + E KS + E ++ +K +K
Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841
Query: 485 TAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVS 544
EE+ P + ++ DS K +A PKP V E K PA+ + + V
Sbjct: 842 AEEEKAPATPKTEEKKDS--KKEEAPKK--EAPKPKVEEKKE----PAVEKPKESKVEAK 893
Query: 545 DAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKE----KEKRRKLLE 600
+++ K K ++ A K++ KK K KE EK+ E
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953
Query: 601 KSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQIND 660
K + K K K + K + K+ K KA K+ ++ + +D +
Sbjct: 954 KKDTKEE-KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE--- 1009
Query: 661 AKKTEKKKKK 670
K TE K K
Sbjct: 1010 -KATEDKAAK 1018
Score = 54.3 bits (129), Expect = 4e-07
Identities = 118/532 (22%), Positives = 204/532 (38%), Gaps = 60/532 (11%)
Query: 177 ISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDF 236
I + KV+++ + K EKS + + E + EEE K+ +EE ++ +
Sbjct: 429 IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEG 488
Query: 237 FEDIDSDEDEGGLFGSK--------------------KLKSGKSSRNLKYKDFFDP--VE 274
E+ +E EGG +K + KS +++ + ++ P V+
Sbjct: 489 GEE---EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 275 SDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKE--SLKRVT 332
S E + +E S E +EEA+ + ++ E E+ K E S ++
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605
Query: 333 FALPDDAETEDTGVLNVK---KNSDEVKS-----SFEKRQEKMNEKIASLEKELLEKKPW 384
+ ++A++ VK K+ EVKS S K + K EK S EKE K P
Sbjct: 606 SPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE-EAKSPE 664
Query: 385 QLQGEVTAQ-KRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVR 443
+ + V A+ K PE + + + EE + + K ++++A
Sbjct: 665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKSPEKA 722
Query: 444 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSL 503
K KE+A +K + E++K S + E K K+ E + P E + D
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAK-SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD-- 779
Query: 504 FLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDI 563
F K PV E + E A + + A +EI +K +
Sbjct: 780 --------KFPEKAKSPVKE--------EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 564 KTAAEKTATDKKRERRKKKYQKRMKI--KEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQ 621
EK K +E KK +++ K +EK+ E++ +A K E +
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 622 LTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQD 673
K K K+E +DK + + + +VK +KTE KK+ D
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD 935
>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member B [Homo sapiens]
Length = 251
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/142 (29%), Positives = 69/142 (48%), Gaps = 24/142 (16%)
Query: 202 DKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSS 261
+ FKL YL+ ++E++ D+D E + +D E+ + EDE
Sbjct: 133 ESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDE--------------- 177
Query: 262 RNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDN 321
+ +D D E + D + D++++ +++DDE++EEE EE + E DED+D E E+
Sbjct: 178 ---EDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEE-EEFGLDEEDEDEDEDEEEEE 233
Query: 322 KQHKESLKRVTFALPDDAETED 343
E KR T D E ED
Sbjct: 234 GGKGEKRKRET-----DDEGED 250
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/207 (24%), Positives = 89/207 (42%), Gaps = 47/207 (22%)
Query: 35 LASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNA 94
LA K +LT + NK+ + + PL+KL + + L+L N + N
Sbjct: 83 LAEKLPNLTHLNLSGNKLKDISTLE--PLKKL--------ECLKSLDLFNCEVTNL--ND 130
Query: 95 VSETINDEDISLLPE--------SEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDP 146
E++ LLP+ E+QE + +E++ D+E+ E+EE D ++D
Sbjct: 131 YRESV----FKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEE----EDEEGEDEEDEDD 182
Query: 147 EMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFK 206
E GE E + D V DED D ++S+ E++ + + + + ++
Sbjct: 183 EDGEEEEFDEEDD-EDEDVEGDEDDD---EVSEEEEEFGLDEEDEDEDEDEE-------- 230
Query: 207 LSEMEAYLENIEKEEERKDDNDEEEED 233
E K E+RK + D+E ED
Sbjct: 231 -------EEEGGKGEKRKRETDDEGED 250
Score = 36.6 bits (83), Expect = 0.079
Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 97 ETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVS-DMGNDDPEMGERAENS 155
E DED E E E +++ ++E D+ +D EEEE D ++D + E E
Sbjct: 175 EDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEG 234
Query: 156 SKSDLRKSPVFSDEDSD 172
K + RK + + D
Sbjct: 235 GKGEKRKRETDDEGEDD 251
Score = 35.0 bits (79), Expect = 0.23
Identities = 22/83 (26%), Positives = 38/83 (45%)
Query: 288 DSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVL 347
DS+ E D + EEE +E E DEDD+ E E+ + + + V DD +E+
Sbjct: 157 DSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEF 216
Query: 348 NVKKNSDEVKSSFEKRQEKMNEK 370
+ + ++ E+ + EK
Sbjct: 217 GLDEEDEDEDEDEEEEEGGKGEK 239
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 61.6 bits (148), Expect = 2e-09
Identities = 66/313 (21%), Positives = 127/313 (40%), Gaps = 25/313 (7%)
Query: 109 ESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSD 168
E E QE E++ E E + + + E E E + + + ER + R D
Sbjct: 299 EKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERD 358
Query: 169 EDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDND 228
D D + D + ++S +NK + + REKS ++ + E+E ER+ + +
Sbjct: 359 RDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE 418
Query: 229 -EEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE-SDEDITNVHDDE 286
E E + + + D +EDE + +KL+ + Y++ E + T ++ E
Sbjct: 419 REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478
Query: 287 LDSNKEDDEIAEEEAEELSISETDEDDD---------------LQENE--------DNKQ 323
+ +E +EA+ L D DDD L++ E D K+
Sbjct: 479 AEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKR 538
Query: 324 HKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKP 383
KE L+ + L + + L + E + + +QE +E+ ++E EK+
Sbjct: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE 598
Query: 384 WQLQGEVTAQKRP 396
++ E +++P
Sbjct: 599 EPMEEEEEPEQKP 611
Score = 51.2 bits (121), Expect = 3e-06
Identities = 82/425 (19%), Positives = 167/425 (39%), Gaps = 35/425 (8%)
Query: 93 NAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERA 152
NA ET+ ++D L E ++ + IE +E +L + + E+
Sbjct: 182 NARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKK 241
Query: 153 ENS---------------SKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREK 197
E+ +K D+ + D+ + +ISK K + +GK ++
Sbjct: 242 EDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKE 301
Query: 198 SIVDDKFFKLSEMEAYLENIEKEEERKDDND---EEEEDIDFFEDIDSDEDEGGLFGSKK 254
+K + E E E +E ER+ + + E+E++ + + D D D +K+
Sbjct: 302 RQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDR-----TKE 356
Query: 255 LKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDD 314
+ + +D + ++D + + D +E + E E E E + + +
Sbjct: 357 RDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE 416
Query: 315 LQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKM-NEKIAS 373
+E E ++ ++ KR D E ++ +K +++ QE++ N +I
Sbjct: 417 -REREREREREKDKKR-------DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRE 468
Query: 374 LEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRI 433
+K +K + + E + E L+E L R P + LQ ++ R
Sbjct: 469 RKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR--LRDRE 526
Query: 434 RDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEH 493
++ D+ RK + KE+ E ++RL + + + EQE + Q + +E E
Sbjct: 527 KEMEADERDRK-REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 494 VEIQK 498
E +K
Sbjct: 586 EEEEK 590
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/126 (19%), Positives = 65/126 (51%), Gaps = 8/126 (6%)
Query: 552 EEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMK---IKEKEKRRKLLEKSSVDQAG 608
E+ K++++ D + A E+ ++K ++ YQ+R+K I+E++K R+ +++ ++
Sbjct: 426 EKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEER 485
Query: 609 KYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKK 668
+ +++LK+ + D+ D A +L+D+ K D + +++K
Sbjct: 486 RREMAKEAKRLKEFLED-----YDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK 540
Query: 669 KKRQDI 674
++ ++I
Sbjct: 541 EELEEI 546
Score = 34.7 bits (78), Expect = 0.30
Identities = 52/281 (18%), Positives = 114/281 (40%), Gaps = 21/281 (7%)
Query: 394 KRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYE 453
K PE++L L D + ++ + + + + + +A + R E D E
Sbjct: 135 KEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEE 194
Query: 454 YKKRLTLDHEKSKLSLAEIYEQEYI-KLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSN 512
T ++ E+ +EY +LN + +P + +K K D
Sbjct: 195 ALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEK-------KEDIFRR 247
Query: 513 FHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTAT 572
F P P P I ++ AI MEE +S +E +K D E+
Sbjct: 248 FPVAPLIPYPLI-TKEDINAIEMEEDKRDLIS----------REISKFRDTHKKLEEEKG 296
Query: 573 DKKRERRKKKYQKRMKIKEKEKRRKLLEKS-SVDQAGKYSKTVASEKLKQLTKTGKASFI 631
K++ER++ + ++R + +E+E+ R+ E+ ++ + K E+ ++ + +
Sbjct: 297 KKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKE 356
Query: 632 KDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQ 672
+D +D+ + + D+ K + +K+ ++++R+
Sbjct: 357 RDRDRDRE-RDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 61.6 bits (148), Expect = 2e-09
Identities = 123/642 (19%), Positives = 266/642 (41%), Gaps = 66/642 (10%)
Query: 70 NFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKED 129
+F E W + P+ Y ++ S+++ + + E ++ R + + + D +E
Sbjct: 851 DFKGEDSW------DSPVTDY-RDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREP 903
Query: 130 LEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNK 189
++ + D ++ + S L + E ++ D + K +
Sbjct: 904 FFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRD 963
Query: 190 GQGKPRE------KSIVDDKFFKLSEMEAYLENIE--------KEEERKDDNDEEEEDI- 234
G+ KP E K + FK + + +E +E+E+KD D+E ++
Sbjct: 964 GRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKT 1023
Query: 235 --DFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKE 292
+ +++ SD+D+ +K + K +K+ D E +D T+ D E ++ +
Sbjct: 1024 KPERYKEKSSDKDKSEKSILEKCQKDKEFDKC-FKEKKDTKEKHKD-THGKDKERKASLD 1081
Query: 293 DDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLN---- 348
+ +E+A ISE D E +D+K+ KE + D++E + +
Sbjct: 1082 QGKEKKEKAFPGIISE-----DFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFK 1136
Query: 349 VKKNSDEVKSSFEKRQEKMNEKIAS--LEKELLEKKPWQLQGEVTAQKRPENSLLEETLH 406
+ + SD ++ + +E+ E AS K ++ P + + + +R + +
Sbjct: 1137 MGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGR- 1195
Query: 407 FDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSK 466
D ++ E+ + + K R +D+A D + +K K+ E ++ +K+K
Sbjct: 1196 -DKKEKVFEKHKEKKDKESTEKYKDR-KDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAK 1253
Query: 467 LSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFL--------KLDALSNFHFIPK 518
E ++E+ K ++K++ + E ++K+ + K+ +S+ F +
Sbjct: 1254 SKHKEKSDKEHSK--ERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDR 1311
Query: 519 PPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRER 578
P + L E ++A L PE++KEK + ++++K+ RER
Sbjct: 1312 GQEPGLTAF--LEVSFTEPPGDDKPRESACL-PEKLKEKERHRHSSSSSKKS---HDRER 1365
Query: 579 RKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDK 638
KK+ K ++KEK E S +G+Y K + G + +K + +D+
Sbjct: 1366 AKKE-----KAEKKEKGEDYKEGGSRKDSGQYEK-----DFLEADAYGVSYNMKADIEDE 1415
Query: 639 ALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLK 680
K+ + F ++ +D+ + +KK EK+ K +++ LK
Sbjct: 1416 LDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILK 1457
Score = 46.6 bits (109), Expect = 8e-05
Identities = 65/335 (19%), Positives = 131/335 (39%), Gaps = 70/335 (20%)
Query: 64 QKLVIENFDDEQIWQQLELQNEPILQ-----------------YFQNAVSETINDE---D 103
+K ++E ++E + + E N+ I + + + + +E D+ +
Sbjct: 1277 EKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRE 1336
Query: 104 ISLLPES---EEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSS-KSD 159
+ LPE +E+ R S ++ D+E + E+ E + G D E G R ++ + D
Sbjct: 1337 SACLPEKLKEKERHRHSSSSSKKSHDRERAKK-EKAEKKEKGEDYKEGGSRKDSGQYEKD 1395
Query: 160 LRKSPVF-------SDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEA 212
++ + +D + +LD I + K +N + +P +K + K + S +
Sbjct: 1396 FLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINI 1455
Query: 213 YLENIEKEEERKDDNDEEEEDIDFFED--------------------------------I 240
E ++E+ R+ DE+E D D
Sbjct: 1456 LKEKKKREKHREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLK 1515
Query: 241 DSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVE----SDEDITNVHDDELDSNKEDDEI 296
D DEG G KLK + ++ K+ DPV+ +D+ + + D+ + +
Sbjct: 1516 DKSRDEGPRLGDAKLK--EKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLL 1573
Query: 297 AEEEAEELSISETDEDDDLQENEDNKQHKESLKRV 331
+ + S DL+ E +K+HKE +K++
Sbjct: 1574 GDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQM 1608
Score = 38.1 bits (87), Expect = 0.027
Identities = 64/297 (21%), Positives = 113/297 (38%), Gaps = 35/297 (11%)
Query: 328 LKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQ 387
LK T+ D + D +L S E K K +K L K LE+K W +
Sbjct: 654 LKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFK 713
Query: 388 GEVTAQKRPEN------SLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDV 441
E + ++ + S EE + A + + + + + K+ + ++ D
Sbjct: 714 DEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRP 773
Query: 442 VRKEKP---KEDAYEYKKRLTLDHEKSKLSLAEIYEQ-----EYIKLNQQKTAEEENPEH 493
+ EK KED +K +K KL ++Y + EY NQ E E+ +
Sbjct: 774 SKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ--FLENEDTKF 831
Query: 494 VEIQKMMDSLFLKLDALSNFHFIPK----PPVPEIK-----VVSNLPAITMEEVAPVSVS 544
D F L S+F F + PV + + V+ L T++E +
Sbjct: 832 SLSDDQRDRWFSDLSD-SSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRR 890
Query: 545 DAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKI----KEKEKRRK 597
D+ + +E ++ DK E+RK++ +K + EK+K+R+
Sbjct: 891 DSRAREKRDYRE-----PFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRR 942
Score = 34.3 bits (77), Expect = 0.39
Identities = 104/536 (19%), Positives = 196/536 (36%), Gaps = 109/536 (20%)
Query: 208 SEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYK 267
SE E L++ K E + +++ +F ED + D ++L K
Sbjct: 321 SEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDR-----------VPPVDDKHLLKK 369
Query: 268 DFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKES 327
D+ +S+ I+ + E+ S +++ IA ++A +S+T +++D E
Sbjct: 370 DYRKETKSNSFIS-IPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTG---EK 425
Query: 328 LKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQE-------KMNEKIASLEKELLE 380
L+ + ++T + +K ++VK +K + K ++K S E E
Sbjct: 426 LRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSSESESES 485
Query: 381 KKPWQ-----------LQGEVTAQKRPEN-SLLEETLHFDH----AVRMAPVITEETTLQ 424
+ + L+G K P S L + H A + P T++ T
Sbjct: 486 SESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKH 545
Query: 425 LEDIIKQRIRDQAWDDV-----------------------VRKEKPKEDAYEYKKRLTLD 461
+ I AW +V V KP E++KR +L
Sbjct: 546 WRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLS 605
Query: 462 HEKSK-LSLAE-----------------------IYEQEYIKLNQQKTAEEENPEHVEIQ 497
+KS LS AE E+ ++Q+ + E+ + +
Sbjct: 606 EKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSK 665
Query: 498 KMMDSLFLKLDALS--NFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLA----- 550
+ D L + LS N + K K L + +EE + + +L
Sbjct: 666 QKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTN 725
Query: 551 -------PEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSS 603
EE NKA ++ EK+ +E + + Y++ K K K++ KL +K+
Sbjct: 726 KDISRSFREEKDRSNKAEKERSLKEKS----PKEEKLRLYKEERKKKSKDRPSKLEKKND 781
Query: 604 V--DQAGKYSKTVASEKLKQLTK----TGKASFIKDEGKDKALKSSQAFFSKLQDQ 653
+ D+ K + + E ++L K ++F + K++ L++ FS DQ
Sbjct: 782 LKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQ 837
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 61.2 bits (147), Expect = 3e-09
Identities = 108/598 (18%), Positives = 240/598 (40%), Gaps = 81/598 (13%)
Query: 103 DISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRK 162
D LL E E+E+E +A+ + + E + + +R E ++ +
Sbjct: 1343 DCDLLREQYEEEQEA-----KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 163 SPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEE 222
+ D + ++ +K K + + Q + V+D + A ++K++
Sbjct: 1398 AQRLQDAEEHVEAVNAKCASLEKTKQRLQNE------VEDLMIDVERTNAACAALDKKQR 1451
Query: 223 RKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNV 282
D E + +E L S+K S+ K K+ ++ E +
Sbjct: 1452 NFDKILAEWKQ-------KCEETHAELEASQKESRSLSTELFKIKNAYE-----ESL--- 1496
Query: 283 HDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAET- 341
D+L++ K +++ ++E +L+ + + E E K+ E K A ++AE
Sbjct: 1497 --DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554
Query: 342 ---EDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKE---LLEKKPWQLQGEVTAQ-- 393
E+ +L ++ ++VKS +++ + +E+I +++ ++E L E+ ++
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND 1614
Query: 394 -----KRPENSLLEETLHFDHAVRMAP----------VITEETTLQLEDIIKQRIRDQAW 438
K+ E L E + +HA RMA I ++T L L+D ++ +
Sbjct: 1615 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ------ 1668
Query: 439 DDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQK 498
+ K++L + ++ L AEI E +++ + E ++ +
Sbjct: 1669 -------------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASE 1715
Query: 499 MMDSLFLKLDALSNFHFIPKPPVPEIKVVSN---LPAITMEEVAPVSVSDAALLAPEEIK 555
+ L + +L N + + +I+ A EE A +++DAA++A E K
Sbjct: 1716 RVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 556 EKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLE------KSSVDQAGK 609
E++ + ++ + K + + +++ +K +K+ + LE + V+ K
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1835
Query: 610 YSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKK 667
+ K K + ++ +E + L+ Q KLQ +VK A++ E++
Sbjct: 1836 RNVEAVKGLRKHERKVKELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/352 (22%), Positives = 144/352 (40%), Gaps = 69/352 (19%)
Query: 339 AETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPEN 398
AETE + N+K+ ++ K K + K E + + EK QLQ + A +
Sbjct: 847 AETEKE-MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA-----D 900
Query: 399 SLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDD-------VVRKEKPKEDA 451
SL + D ++ T +QLE IK+ + ++A D+ +K K +++
Sbjct: 901 SLADAEERCDQLIK--------TKIQLEAKIKE-VTERAEDEEEINAELTAKKRKLEDEC 951
Query: 452 YEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALS 511
E KK D + +L+LA++ ++++ N+ K EE +D KL
Sbjct: 952 SELKK----DIDDLELTLAKVEKEKHATENKVKNLTEE-------MAGLDETIAKL---- 996
Query: 512 NFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAE--- 568
E K + T++++ L +IK + + D++ + E
Sbjct: 997 ---------TKEKKALQEAHQQTLDDL-QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK 1046
Query: 569 KTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKA 628
K D +R +RK E KL ++S++D + K K+ +G
Sbjct: 1047 KIRMDLERAKRK-----------LEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 629 SFIKDEGK-----DKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDIS 675
S I+DE K +K QA +L+++++ + K E K+R D+S
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE---KQRSDLS 1144
Score = 47.0 bits (110), Expect = 6e-05
Identities = 132/708 (18%), Positives = 274/708 (38%), Gaps = 106/708 (14%)
Query: 53 LENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEE 112
+E+ + G LQK + +++ ++E E I + D+S E
Sbjct: 1098 IEDEQALGMQLQKKI------KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 113 QEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSD 172
+ EE G A + ++ E E M D E + E ++ + LRK +D ++
Sbjct: 1152 ERLEEAGGATSA--QIEMNKKREAEFQKMRRDLEEATLQHE-ATAATLRKK--HADSVAE 1206
Query: 173 LDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEK-----EEERKDDN 227
L I L++ + K K K +DD + + N+EK E++ +
Sbjct: 1207 LGEQIDNLQRVKQKLEKE--KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK 1264
Query: 228 DEEEEDIDFFEDIDSD----EDEGGLFGSK---------KLKSGKSSRNLKYKDFFDPVE 274
+EEE D+ + + E G + + +L GK + + ++ +E
Sbjct: 1265 TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 275 SDEDITNVHDDELDSNKEDDEIAEEEAEELSISETD-------------------EDDDL 315
+ + L S++ D ++ E+ EE ++ + E D +
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAI 1384
Query: 316 QENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQ---EKMNEKIA 372
Q E+ ++ K+ L + + E + +++K +++ E E+ N A
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444
Query: 373 SLEKELL---------EKKPWQLQGEVTAQKRPENSLLEETLHFDHAV-----RMAPVIT 418
+L+K+ ++K + E+ A ++ SL E +A ++ +
Sbjct: 1445 ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKR 1504
Query: 419 EETTLQLE--DIIKQ------RIRD-QAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSL 469
E LQ E D+ +Q RI + + V +EK + A + +L+HE+ K+
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR 1564
Query: 470 AEIYEQEYIKLNQQKTAEEENP------EHVEI-QKMMDSLFLKLDALSNFHFIPKP--- 519
++ + +K AE++ H+ I + M +L ++ + ++ + K
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624
Query: 520 PVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRER- 578
+ E+++ N E + A+L ++ + + E+ A ++R
Sbjct: 1625 DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 579 -RKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGK- 636
+ + + R +++ E+ RK+ E+ +D ASE++ QL T S I + K
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELLD---------ASERV-QLLHTQNTSLINTKKKL 1734
Query: 637 DKALKSSQAFFSKL-------QDQVKMQINDAKKTEKKKKKRQDISVH 677
+ + Q + +++ K I DA ++ KK QD S H
Sbjct: 1735 ETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 60.8 bits (146), Expect = 4e-09
Identities = 56/254 (22%), Positives = 117/254 (46%), Gaps = 32/254 (12%)
Query: 91 FQNAVSETINDEDISLLPESEEQEREEDGSEIEADD-------KEDLEDLEEEEVSDMGN 143
F+ + S+ ++E + E+ ++E + +D KE +DL +E ++G
Sbjct: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
Query: 144 DDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDK 203
+ +E S D + S++ S+ +F+ + LE+ + +G K ++++D +
Sbjct: 536 TKESEEDDSEKESDEDCSEKQ--SEDGSEREFEENGLEKD--LDEEGSEKELHENVLDKE 591
Query: 204 F---------FKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFE---DIDSDEDEGGLFG 251
F+ E L+ E E +D+DE+EE+ D +E D +SDE E +
Sbjct: 592 LEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYA 651
Query: 252 SKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDE 311
+K G + + K ++ ++DE + DD+ D + + E+ E+A+E + D
Sbjct: 652 DEK---GLEAADKKAEE----GDADEKLFEESDDKEDEDADGKEV--EDADEKLFEDDDS 702
Query: 312 DDDLQENEDNKQHK 325
++ L + E++ K
Sbjct: 703 NEKLFDEEEDSSEK 716
Score = 60.1 bits (144), Expect = 7e-09
Identities = 72/279 (25%), Positives = 117/279 (41%), Gaps = 52/279 (18%)
Query: 109 ESEE----QEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSP 164
ESEE + EED + E+ K D EE ++ DD S+ ++ +
Sbjct: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDD------LNKESEEEVGPTK 537
Query: 165 VFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERK 224
++DS+ + D E+QS ++ + + E + D + SE E + ++KE E
Sbjct: 538 ESEEDDSEKESDEDCSEKQS--EDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
Query: 225 DDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHD 284
D + E ED GS+K+ + S +D + E ++ V D
Sbjct: 596 DSENSEFEDD----------------GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFD 639
Query: 285 DELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDT 344
DE D KED+E A+E+ E + + +E D D K +ES DD E ED
Sbjct: 640 DESDE-KEDEEYADEKGLEAADKKAEEGD-----ADEKLFEES---------DDKEDEDA 684
Query: 345 GVLNVKKNSDEVKSSFEK--RQEKMNEKIASLEKELLEK 381
+ EV+ + EK + NEK+ E++ EK
Sbjct: 685 -------DGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
Score = 55.8 bits (133), Expect = 1e-07
Identities = 66/290 (22%), Positives = 113/290 (38%), Gaps = 37/290 (12%)
Query: 109 ESEEQEREEDGSEIEA-----DDKEDLEDLEEEEVSDMGNDD---PEMGERAENSSKSDL 160
+ ++ E+ EDG E E + KE + E EE + P+ G S K
Sbjct: 427 DEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESE 486
Query: 161 RKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKE 220
+PV E+ + K ++ + G K E D K SE E +
Sbjct: 487 EGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESE-----DDLNKESE-----EEVGPT 536
Query: 221 EERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDIT 280
+E ++D+ E+E D D E D GS++ + N KD + E
Sbjct: 537 KESEEDDSEKESDEDCSEKQSED-------GSER----EFEENGLEKDLDEEGSEKELHE 585
Query: 281 NVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTF-----AL 335
NV D EL+ N ++ E++ E + E + + E+ D K+ +E F
Sbjct: 586 NVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEK 645
Query: 336 PDDAETEDTGVLNVKKNSDEVKSS---FEKRQEKMNEKIASLEKELLEKK 382
D+ ++ G+ K ++E + FE+ +K +E E E ++K
Sbjct: 646 EDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEK 695
Score = 37.0 bits (84), Expect = 0.060
Identities = 41/152 (26%), Positives = 67/152 (44%), Gaps = 27/152 (17%)
Query: 83 QNEPILQYFQNAVSETINDEDIS---LLPESEEQEREEDGSEIEADDKEDLEDLEEEEVS 139
+N+ F++ SE + DE+ S +S+E+E EED E DD+ D + E+EE +
Sbjct: 594 ENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESD--EKEDEEYA 651
Query: 140 DMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSI 199
D E G A + E+ D D KL ++S + +E
Sbjct: 652 D------EKGLEAADKKA-----------EEGDAD---EKLFEESDDKEDEDADGKEVED 691
Query: 200 VDDKFFKLSEMEAYLENIEKEEERK--DDNDE 229
D+K F+ + L + E++ K DD+DE
Sbjct: 692 ADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.127 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,860,582
Number of Sequences: 37866
Number of extensions: 1360518
Number of successful extensions: 24818
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 396
Number of HSP's successfully gapped in prelim test: 1104
Number of HSP's that attempted gapping in prelim test: 8851
Number of HSP's gapped (non-prelim): 8380
length of query: 681
length of database: 18,247,518
effective HSP length: 109
effective length of query: 572
effective length of database: 14,120,124
effective search space: 8076710928
effective search space used: 8076710928
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.