Search of human proteins with 31317272

Search of human proteins with 31317272

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31317272 WD repeat and FYVE domain containing 3 isoform 1
[Homo sapiens]
         (3526 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho...  7086   0.0  
gi|191252801 WDFY family member 4 [Homo sapiens]                     1796   0.0  
gi|31317268 WD repeat and FYVE domain containing 3 isoform 2 [Ho...  1546   0.0  
gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Ho...   593   e-168
gi|54292123 lysosomal trafficking regulator [Homo sapiens]            413   e-114
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]             395   e-109
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]             395   e-109
gi|149944548 neurobeachin-like 2 [Homo sapiens]                       395   e-109
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]             382   e-105
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho...   365   e-100
gi|62422577 neurobeachin [Homo sapiens]                               359   2e-98
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ...   294   9e-79
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc...   294   9e-79
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]            100   3e-20
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]            100   3e-20
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]            100   3e-20
gi|217272865 myotubularin related protein 4 [Homo sapiens]             73   4e-12
gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]      70   4e-11
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    68   2e-10
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    68   2e-10
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    68   2e-10
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa...    68   2e-10
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su...    67   3e-10
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    67   3e-10
gi|153791377 apoptosis-inducing protein D [Homo sapiens]               66   5e-10
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...    65   9e-10
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]    65   2e-09
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]    65   2e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             64   3e-09
gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]     62   1e-08

>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
            sapiens]
          Length = 3526

 Score = 7086 bits (18384), Expect = 0.0
 Identities = 3526/3526 (100%), Positives = 3526/3526 (100%)

Query: 1    MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR 60
            MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR
Sbjct: 1    MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR 60

Query: 61   VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA 120
            VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA
Sbjct: 61   VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA 120

Query: 121  SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA 180
            SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA
Sbjct: 121  SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA 180

Query: 181  ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM 240
            ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM
Sbjct: 181  ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM 240

Query: 241  TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL 300
            TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL
Sbjct: 241  TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL 300

Query: 301  LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP 360
            LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP
Sbjct: 301  LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP 360

Query: 361  FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI 420
            FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI
Sbjct: 361  FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI 420

Query: 421  LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI 480
            LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI
Sbjct: 421  LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI 480

Query: 481  IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE 540
            IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE
Sbjct: 481  IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE 540

Query: 541  DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP 600
            DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP
Sbjct: 541  DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP 600

Query: 601  NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA 660
            NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA
Sbjct: 601  NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA 660

Query: 661  MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR 720
            MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR
Sbjct: 661  MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR 720

Query: 721  FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF 780
            FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF
Sbjct: 721  FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF 780

Query: 781  DSRAEQIPPCLTSESSLPSPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQ 840
            DSRAEQIPPCLTSESSLPSPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQ
Sbjct: 781  DSRAEQIPPCLTSESSLPSPWGTPALSRKRHAYHSVSTPPVYPPKNVADLKLHVTTSSLQ 840

Query: 841  SSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGL 900
            SSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGL
Sbjct: 841  SSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGL 900

Query: 901  HARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLL 960
            HARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLL
Sbjct: 901  HARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLL 960

Query: 961  KQYRVHKPSSLSYEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLT 1020
            KQYRVHKPSSLSYEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLT
Sbjct: 961  KQYRVHKPSSLSYEPEMRSSMITSLEGLGTDNVFSLHEDNHYRISKSLVKSAEGSTVPLT 1020

Query: 1021 RVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLID 1080
            RVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLID
Sbjct: 1021 RVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLID 1080

Query: 1081 GAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLA 1140
            GAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLA
Sbjct: 1081 GAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLA 1140

Query: 1141 IVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVM 1200
            IVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVM
Sbjct: 1141 IVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIIEGQWHHLVLVM 1200

Query: 1201 SKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIAS 1260
            SKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIAS
Sbjct: 1201 SKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIAS 1260

Query: 1261 LVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEE 1320
            LVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEE
Sbjct: 1261 LVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEE 1320

Query: 1321 KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGSA 1380
            KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGSA
Sbjct: 1321 KVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGSA 1380

Query: 1381 RTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKS 1440
            RTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKS
Sbjct: 1381 RTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKS 1440

Query: 1441 NPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQD 1500
            NPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQD
Sbjct: 1441 NPLASKEMERIKGYQLLAMLLKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQD 1500

Query: 1501 LLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQ 1560
            LLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQ
Sbjct: 1501 LLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQ 1560

Query: 1561 PTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKLDTGTEE 1620
            PTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKLDTGTEE
Sbjct: 1561 PTIAAISNVLSFLLQGFPSSNDLLRFGQFISSTLPTFAVCEKFVVMEINNEEKLDTGTEE 1620

Query: 1621 EFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGFDWIMMFMEEHLH 1680
            EFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGFDWIMMFMEEHLH
Sbjct: 1621 EFGGLVSANLILLRNRLLDILLKLIYTSKEKTSINLQACEELVKTLGFDWIMMFMEEHLH 1680

Query: 1681 STTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGR 1740
            STTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGR
Sbjct: 1681 STTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGR 1740

Query: 1741 STVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVIS 1800
            STVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVIS
Sbjct: 1741 STVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVIS 1800

Query: 1801 CRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFLLLGMLRSMLTSPWQSEEE 1860
            CRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFLLLGMLRSMLTSPWQSEEE
Sbjct: 1801 CRSKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAVFLLLGMLRSMLTSPWQSEEE 1860

Query: 1861 GSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAATVFPFNIRPYSEMVTDLDDE 1920
            GSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAATVFPFNIRPYSEMVTDLDDE
Sbjct: 1861 GSWLREYPVTLMQFFRYLYHNVPDLASMWMSPDFLCALAATVFPFNIRPYSEMVTDLDDE 1920

Query: 1921 VGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPAS 1980
            VGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPAS
Sbjct: 1921 VGSPAEEFKAFAADTGMNRSQSEYCNVGTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPAS 1980

Query: 1981 KQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQV 2040
            KQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQV
Sbjct: 1981 KQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQV 2040

Query: 2041 LVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTIL 2100
            LVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTIL
Sbjct: 2041 LVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTIL 2100

Query: 2101 YQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGF 2160
            YQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGF
Sbjct: 2101 YQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGF 2160

Query: 2161 GLEAEARMTTWHIMIPSDIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFK 2220
            GLEAEARMTTWHIMIPSDIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFK
Sbjct: 2161 GLEAEARMTTWHIMIPSDIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFK 2220

Query: 2221 VTLPVNERGHVDIATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGF 2280
            VTLPVNERGHVDIATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGF
Sbjct: 2221 VTLPVNERGHVDIATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGF 2280

Query: 2281 GLSKLTGSRRNRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYV 2340
            GLSKLTGSRRNRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYV
Sbjct: 2281 GLSKLTGSRRNRKESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYV 2340

Query: 2341 TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPET 2400
            TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPET
Sbjct: 2341 TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPET 2400

Query: 2401 EQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESS 2460
            EQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESS
Sbjct: 2401 EQETNVASEIPSKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESS 2460

Query: 2461 EGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEK 2520
            EGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEK
Sbjct: 2461 EGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEK 2520

Query: 2521 TDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIE 2580
            TDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIE
Sbjct: 2521 TDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIE 2580

Query: 2581 TLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYL 2640
            TLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYL
Sbjct: 2581 TLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYL 2640

Query: 2641 LAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWER 2700
            LAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWER
Sbjct: 2641 LAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWER 2700

Query: 2701 GEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQT 2760
            GEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQT
Sbjct: 2701 GEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQT 2760

Query: 2761 DERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDL 2820
            DERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDL
Sbjct: 2761 DERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDL 2820

Query: 2821 ADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILP 2880
            ADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILP
Sbjct: 2821 ADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILP 2880

Query: 2881 PWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQV 2940
            PWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQV
Sbjct: 2881 PWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQV 2940

Query: 2941 DIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKI 3000
            DIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKI
Sbjct: 2941 DIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKI 3000

Query: 3001 FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR 3060
            FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR
Sbjct: 3001 FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCR 3060

Query: 3061 LGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLK 3120
            LGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLK
Sbjct: 3061 LGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLK 3120

Query: 3121 QALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINEL 3180
            QALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINEL
Sbjct: 3121 QALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINEL 3180

Query: 3181 TGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGV 3240
            TGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGV
Sbjct: 3181 TGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGV 3240

Query: 3241 VRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDT 3300
            VRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDT
Sbjct: 3241 VRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDT 3300

Query: 3301 PSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHL 3360
            PSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHL
Sbjct: 3301 PSQPSSTSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHL 3360

Query: 3361 QGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISK 3420
            QGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISK
Sbjct: 3361 QGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISK 3420

Query: 3421 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG 3480
            DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG
Sbjct: 3421 DHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCG 3480

Query: 3481 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC 3526
            QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC
Sbjct: 3481 QLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC 3526


>gi|191252801 WDFY family member 4 [Homo sapiens]
          Length = 3184

 Score = 1796 bits (4651), Expect = 0.0
 Identities = 1130/3269 (34%), Positives = 1769/3269 (54%), Gaps = 263/3269 (8%)

Query: 41   HMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKS 100
            H +  E+++ L  +LP+F + + ++        F  L +    VS  +  ++++    K 
Sbjct: 59   HKSPIERQKSLLSLLPLFLKAWEHSVGIIC---FPSLQRLAEDVSDQLAQQLQKALVGKP 115

Query: 101  TEAASRAIVQFL----EINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKC 156
             E A  A  Q L    +++Q      G++LL ++ +L  +  +T+  +    +P+ L++C
Sbjct: 116  AEQARLAAGQLLWWKGDVDQD-----GYLLLKSVYVLTGTDSETLGRVAESGLPALLLQC 170

Query: 157  LYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLL 216
            LYLFF  P          ++  L E    +QK+FVQ+L+ +CS     E L    +LQ L
Sbjct: 171  LYLFFVFP---------LDKDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSL 221

Query: 217  FSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSP 276
              A T         W++    VL  IS+   ++++++Y+   +C+   +QN+ +  D  P
Sbjct: 222  LIATTCLREHSCCFWKEPTFCVLRAISK-AQNLSIIQYLQATDCVRLSLQNLSRLTDTLP 280

Query: 277  L-EIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDL 335
              E+ E  + +  F+KDS  VS  L  +F   +GY  L  +LLR +   ++E    L++L
Sbjct: 281  APEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEEL 340

Query: 336  VNLITSLTTYGVSELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAK 395
            + L+  LTT G SELK     T     L GF     A  G +V+N+QAF VLQN F KA 
Sbjct: 341  LGLVVWLTTCGRSELKVFDSITYPQ--LEGFKFHHEAS-GVTVKNLQAFQVLQNVFHKAS 397

Query: 396  TSFLAQIILDAITNIYMADNANYFILE-SQHTLSQFAEKISKLPE-VQNKYFEMLEFVVF 453
             S L   +L  I  ++  +  N+F+LE +   +SQF E +   P  VQ  +F++LE +VF
Sbjct: 398  DSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVF 457

Query: 454  SLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLL 513
             L+Y+P + L  V  L+K S    C+++A++++L     D +F D+FR+ GLL +++  L
Sbjct: 458  ELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQL 517

Query: 514  HKYAALLKDPTQALNEQGDSRNNSSVED-QKHLALLVMETLTVLLQGSNTNAGIFREFGG 572
             K A +++       + G+  +   V+D ++ L  +++  +  LL+GS  NA + ++ G 
Sbjct: 518  RKQAKIMR-------KSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGM 570

Query: 573  ARCAHNIVKYPQCRQHALMTIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALL 632
                  I    +C + A ++I + + + N ++ M  ++G + S+   ELQLK D+L++LL
Sbjct: 571  VPFI-KIFLDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLL 629

Query: 633  SVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSCPPKNGWEKVNQNQVFELLHTVFCTL 692
             +L  + + R  FR   GF  + SLL  +E SL  PP   W  V+  Q  EL+    C +
Sbjct: 630  RIL-VTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAV 688

Query: 693  TAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAM--NVFPSNTQPFQRLLEE 750
            +AA+ ++P N +FF+    +EKLA+ +  LGCF  L +   +  +   +  +PF  LL  
Sbjct: 689  SAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDTKARPFADLLGT 748

Query: 751  DVISIESVSPTLRHCSKLFIYLYKVATDSFDSRAEQIPPCLTSESSLPSPWGTPALSRKR 810
               S  S+ P ++ C ++  +L  +A+ +   R +        + SL +  G     +K 
Sbjct: 749  AFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDL-------KESLRTKQGPVVDVQKG 801

Query: 811  HAYHSVSTPPVYPPKNVADLKLHVTTSSLQSSDAVIIHPGAMLAMLDLLASVGSVTQPEH 870
                   + P    K   DL+       +   DA I+HPG +  M+ LL  +     P+ 
Sbjct: 802  ET----GSDPQRNFKQWPDLE-----ERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQL 852

Query: 871  ALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERL 930
            + ++Q ++A+ +QSLV +E+N+QVMCEAGL   L+  C  AL      LH  L R+FE+L
Sbjct: 853  SEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFEKL 912

Query: 931  ASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSYEPEMRSSMITSLEGLGT 990
            ASQA+EP VLR+FL L  P +  A   K+L     H+ +      +    +         
Sbjct: 913  ASQAIEPDVLRQFLGLGIPSSLSA-TTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAP 971

Query: 991  DNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDT 1050
            D    LH       +   +  ++ ST  L     L+SMT+P +++   +++ P+FVEFD 
Sbjct: 972  D--AGLHPG--VTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDM 1027

Query: 1051 SLEGFGCLFLPSLAPHNAPTNNTVTTGLIDGAVVSGIGSG-ERFFPPPSGLSYSSWFCIE 1109
            S+EG+GCLF+P+L        +TV     + +V  GIG+G  R FPPP GL++S WF I 
Sbjct: 1028 SVEGYGCLFIPTL--------STVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLIS 1079

Query: 1110 HFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEE 1169
               +    HP+R LT+VR    +EQ +VC ++ L   D SL+VST+E+  Q  +D    E
Sbjct: 1080 RHGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQP-LDVMEPE 1138

Query: 1170 SSFYEILPCCARFRCGELIIEGQWHHLVLVMSKGMLKNSTAALYIDGQLVNTVKLHYVHS 1229
                    C  + RCG+L+  GQWHHL +V++K M ++ T +  +DGQ++ + K+ Y+ +
Sbjct: 1139 DDSEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQA 1198

Query: 1230 TPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPSSNVTTIYELGPN 1289
             PG   S +P     VY YI TP   +Q +SL+WRLGPT+  EE +    +  I +LGP 
Sbjct: 1199 LPGPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPR 1258

Query: 1290 YVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSSLTVARIRKVYNKLDSK 1349
            Y G+FQAV +  +D  SE         V EE+VSFGL+  S S  +VA IR  YN++DS+
Sbjct: 1259 YCGNFQAVHVQGEDLDSEA-----TPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSR 1313

Query: 1350 AIAKQLGISSHENATPVKLIHNSAGHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVG 1409
             IAK++ ISS +NA PV L+ N AGHL+GS RTIGA  +G LGVR F   P A++L ++G
Sbjct: 1314 LIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIG 1373

Query: 1410 GAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLN 1469
            G A +LGL+++A+D   +YAAVK L  V+ SN +    M+ I GYQ++A LL+KK SLLN
Sbjct: 1374 GPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLN 1433

Query: 1470 SHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTE 1529
              I  L  S+ GTV+ G  +S I N+  FQ +LC+FE+W++    L LSLF H +E+L  
Sbjct: 1434 HRIFQLILSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQS 1493

Query: 1530 SSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPSSNDLLRFGQF 1589
              E  +NA+   + QLIPKL+    + SL    I+ I  +L+  L+G  S+ DLLR G F
Sbjct: 1494 PREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLF 1553

Query: 1590 ISSTLPTFAVCEKFVVMEINNEEKLDTGTEEEFGGLVSANLILLRNRLLDILLKLIYTSK 1649
            +  TL   +V E+ + M+   +  L  G++       S   I LRN+LL++LL +I  S 
Sbjct: 1554 VVYTLKPSSVNERQICMDGALDPSLPAGSQ------TSGKTIWLRNQLLEMLLSVI--SS 1605

Query: 1650 EKTSINLQACEELVKTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLS 1709
             +  ++ ++ EE+   LG DW ++ ++ HLH++T   A+++L+  L++ S+  +F++GL 
Sbjct: 1606 PQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLC 1665

Query: 1710 GGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNV 1769
             G W+E++    T  +  V+      +   +S + E  +  C  PGF VL  FL  H ++
Sbjct: 1666 AGSWVERS----TEGVDIVMD-----NLKSQSPLPE--QSPCLLPGFRVLNDFLAHHVHI 1714

Query: 1770 PALYFLLMALFLQQPVSELPENLQVSVPVISCRSKQGCQFDLDSIWTFIFGVPASSGTVV 1829
            P +Y ++   FLQ P++EL +               G +  LD++  ++         + 
Sbjct: 1715 PEVYLIVSTFFLQTPLTELMD---------------GPKDSLDAMLQWLLQRHHQEEVLQ 1759

Query: 1830 SSIHNVCTEAVFLLLGMLRSMLTSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMW 1889
            + +   CTE   LLL ML++ ++ P    E+G+W + +P +++QF   ++   P     W
Sbjct: 1760 AGL---CTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQ-DPAW 1815

Query: 1890 MSPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGT 1949
             +P+FL  LA   FP   +                    K   A++  N S  E    G 
Sbjct: 1816 RAPEFLQTLAIAAFPLGAQ--------------------KGVGAESTRNTSSPEAAAEGD 1855

Query: 1950 KTY------LTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQK 2003
             T          HPA++ + +F ++L+ + L    + KQ   +++LLEASP+ +T  Q++
Sbjct: 1856 STVEGLQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKR 1915

Query: 2004 EFQTYILDSVMD--HLLA-ADVLLGEDASLPITSG-GSYQVLVNNVFYFTQRVVDKLWQG 2059
            +FQ+ +L S M+  H+ +  D  +  D   P  S   +    + N+  FTQ++V+KL+ G
Sbjct: 1916 DFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSG 1975

Query: 2060 MFNKESKLLIDFI---IQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVAL 2116
            MF+ + + ++ FI   I ++ ++    +   L  +Y  LN+ ILY  S+  +++ + + L
Sbjct: 1976 MFSADPRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGL 2035

Query: 2117 LDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIP 2176
            L  L  L  + +++    N +  F+ CL HCL+ L+  S  +GFGLE + RM+T+H +  
Sbjct: 2036 LSILGFLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFL 2095

Query: 2177 S---DIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNE-RGHVD 2232
            S   D++        +S+ +  + K V  +W +L+  ++Q LE+ FK+ L V      V 
Sbjct: 2096 SPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVK 2155

Query: 2233 IATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGFGLSKLTGSRRNR 2292
            I    PL EE  LK WQ++LA EKK ++    +A  ++  L   S    +  + G +   
Sbjct: 2156 IEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKD 2215

Query: 2293 KESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELL 2352
             E         T++    +  +    ++L  + YK++ +R++         W +I+ +L 
Sbjct: 2216 PE-------CKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLF 2268

Query: 2353 RERGLWGPPIGSH-LDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQETNVASEIP 2411
             E GLW     +     W L+  EGP RMRK++ R                   ++S   
Sbjct: 2269 GELGLWSQGEETKPCSPWELDWREGPARMRKRIKR-------------LSPLEALSSGRH 2315

Query: 2412 SKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEH 2471
             +  +  D I Q          + +  E  +R A G P  V     + +   A   E  H
Sbjct: 2316 KESQDKNDHISQTN--------AENQDELTLREAEGEPDEVGVDCTQLTFFPAL-HESLH 2366

Query: 2472 GEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLL---- 2527
             ED +   +                   E Q  LQ+       +++E+ T   +L+    
Sbjct: 2367 SEDFLELCR-------------------ERQVILQE------LLDKEKVTQKFSLVIVQG 2401

Query: 2528 RLLEEGEKI---QHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPP 2584
             L+ EG  +   QH Y C                       + FT++ T ++        
Sbjct: 2402 HLVSEGVLLFGHQHFYIC-----------------------ENFTLSPTGDVYCTRHCLS 2438

Query: 2585 NMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQ 2644
            N+ +P I     +  S    +C   +Y D++E+ + R+LLQ IA+E+F  +G +  L F 
Sbjct: 2439 NISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFY 2498

Query: 2645 KGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEIS 2704
               R+K ++ F +  PSL   + S        S+ +  G       ++ + Q+W++ +IS
Sbjct: 2499 NNDRSKAFKSFCSFQPSLKGKATS----EDTLSLRRYPG------SDRIMLQKWQKRDIS 2548

Query: 2705 NFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERL 2764
            NF+YLM+LNT AGR+ ND MQYPVFPW+LADY SE ++L NPK FR+L+KPMGAQT ER 
Sbjct: 2549 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK 2608

Query: 2765 AQYKKRYKDWEDPNGE-TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADR 2823
             ++ +R+K+ E   G+ T   HY THYSSA+IVASYLVRM PFTQ F  LQGG FD+ADR
Sbjct: 2609 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR 2668

Query: 2824 MFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWA 2883
            MFHSV+  W SAS+ NM+DV+EL PEFFYLPEFL N N  + GC Q+GT LGDV LPPWA
Sbjct: 2669 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA 2728

Query: 2884 KGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIY 2943
             GDPR+FI +HR+ALE D+VSA+LH WIDLIFGYKQQGPAAV+AVN+FH  FY  ++D+ 
Sbjct: 2729 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS 2788

Query: 2944 NINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSR-LNGDNAGISV-LPGSTSDKIF 3001
            +I DPL ++  +GF++NFGQ+PKQLF KPHP +    + L G +    V LPG      F
Sbjct: 2789 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQP--F 2846

Query: 3002 FHHLDNLRPSLTPVKEL----------KEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFA 3051
            F+ L +LRPS   VK++          K  +G IV T+K ILAVE+NKVL+PP WN+TF+
Sbjct: 2847 FYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFS 2906

Query: 3052 WGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSK 3111
            WG+ D SC LG+Y SDK +  +E L+ WG+ LCA+CP+P  ++T GTSTVVCVWE+  +K
Sbjct: 2907 WGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTK 2966

Query: 3112 EKAKTVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAP 3171
             + + + L+QAL GHT  VTC  AS+ + ++VSGS+D TCI+WDL+ L+ +T+L  HR  
Sbjct: 2967 GRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREG 3026

Query: 3172 VSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNV 3231
            +SA+ I++++G IVSCAG ++ +W++NG P+ S+ T  G    I CCC+ E   WDT  +
Sbjct: 3027 ISAITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086

Query: 3232 IVTGHSDGVVRFWRME--FLQVPETPAPE 3258
            I+TG  DG+VR W+ E   + VP  PA E
Sbjct: 3087 IITGSQDGMVRVWKTEDVKMSVPGRPAGE 3115



 Score = 55.5 bits (132), Expect = 9e-07
 Identities = 23/56 (41%), Positives = 36/56 (64%)

Query: 3383 GYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSWS 3438
            G++WE+ L    +L +  A   K +     VTAL +S++H+++LVGD RGR+F WS
Sbjct: 3126 GHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWS 3181


>gi|31317268 WD repeat and FYVE domain containing 3 isoform 2 [Homo
           sapiens]
          Length = 795

 Score = 1546 bits (4002), Expect = 0.0
 Identities = 781/781 (100%), Positives = 781/781 (100%)

Query: 1   MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR 60
           MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR
Sbjct: 1   MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNR 60

Query: 61  VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA 120
           VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA
Sbjct: 61  VFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEA 120

Query: 121 SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA 180
           SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA
Sbjct: 121 SRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLA 180

Query: 181 ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM 240
           ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM
Sbjct: 181 ERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLM 240

Query: 241 TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL 300
           TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL
Sbjct: 241 TISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTL 300

Query: 301 LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP 360
           LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP
Sbjct: 301 LDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVSELKPAGITTGAP 360

Query: 361 FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI 420
           FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI
Sbjct: 361 FLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAKTSFLAQIILDAITNIYMADNANYFI 420

Query: 421 LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI 480
           LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI
Sbjct: 421 LESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSI 480

Query: 481 IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE 540
           IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE
Sbjct: 481 IAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSVE 540

Query: 541 DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP 600
           DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP
Sbjct: 541 DQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVLSP 600

Query: 601 NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA 660
           NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA
Sbjct: 601 NGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVA 660

Query: 661 MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR 720
           MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR
Sbjct: 661 MERSLSCPPKNGWEKVNQNQVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVR 720

Query: 721 FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF 780
           FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF
Sbjct: 721 FLGCFSDLRKISAMNVFPSNTQPFQRLLEEDVISIESVSPTLRHCSKLFIYLYKVATDSF 780

Query: 781 D 781
           D
Sbjct: 781 D 781


>gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Homo
            sapiens]
          Length = 281

 Score =  593 bits (1529), Expect = e-168
 Identities = 281/281 (100%), Positives = 281/281 (100%)

Query: 3246 MEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDTPSQPS 3305
            MEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDTPSQPS
Sbjct: 1    MEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSISQDPKDTPSQPS 60

Query: 3306 STSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHLQGPLS 3365
            STSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHLQGPLS
Sbjct: 61   STSHRPRAASCRATAAWCTDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQTRAHLQGPLS 120

Query: 3366 HPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRI 3425
            HPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRI
Sbjct: 121  HPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRI 180

Query: 3426 LVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQ 3485
            LVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQ
Sbjct: 181  LVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQ 240

Query: 3486 KCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC 3526
            KCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC
Sbjct: 241  KCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSEDGPRNC 281


>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
          Length = 3801

 Score =  413 bits (1061), Expect = e-114
 Identities = 278/807 (34%), Positives = 412/807 (51%), Gaps = 112/807 (13%)

Query: 2501 NQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEG--EKIQHMYRCARVQGLDTSEGLLLFG 2558
            ++++ +D +    S   E+KT ++    + ++   E I+   RC  V     + G LL G
Sbjct: 2977 DRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLG 3036

Query: 2559 KEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVH 2618
            K   Y ++                  +     +   + QG  +L+     + YE+IKEVH
Sbjct: 3037 KCGMYFVE------------------DNASDTVESSSLQG--ELEPASFSWTYEEIKEVH 3076

Query: 2619 KRRYLLQPIAVEVFSGDGRNYLLAFQKG-IRNKVYQRFLAVVPSLTDSSESVSGQRPNTS 2677
            KR + L+  AVE+F  +GR  LLAF    +R+ VY   L             +   PN  
Sbjct: 3077 KRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNIL-------------TNNLPNL- 3122

Query: 2678 VEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYD 2737
            +E G+          ++T  W  G+I+NF+YL HLN  AGRS+NDLMQYPVFP+ILADY 
Sbjct: 3123 LEYGN--------ITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYV 3174

Query: 2738 SEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWE----------DPNGETPAYHYG 2787
            SE +DL +   +RNL+KP+  Q  E+  +Y   YK  E          DP      YHYG
Sbjct: 3175 SETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYG 3234

Query: 2788 THYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELI 2847
            +HYS++  V  +LVRM PFT++FL  Q   FD+ DR FHS    W  +S  +M DVKELI
Sbjct: 3235 SHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELI 3294

Query: 2848 PEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHL 2907
            PEFFYLPEFL N   FD G +QNG ++  V LPPWA+ DPR FI +HR+ALE DYVS ++
Sbjct: 3295 PEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNI 3354

Query: 2908 HEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQ 2967
             +WIDL+FGYKQ+G A+V+A+NVFH   Y G +D+  + DP++  A    I  +GQ P+Q
Sbjct: 3355 CQWIDLVFGYKQKGKASVQAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQ 3413

Query: 2968 LFKKPHPPKRVRSRLNGDN---AGISVLPGSTSDKIFFHHLDNLRPS-LTPVKELK--EP 3021
            LF   H   R  ++LN +    A + +L      +      +   PS L+ +K LK  E 
Sbjct: 3414 LFHMAH-VSRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEY 3472

Query: 3022 VGQ------IVC---------------TDKGILAVEQNKVLIPP---------------T 3045
            VG       +VC                 + I  + +N  L+                  
Sbjct: 3473 VGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQ 3532

Query: 3046 WNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVW 3105
            W+   +WGYAD   RL + +S+  +   +   ++    CA  P+   + TG    V+  +
Sbjct: 3533 WSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAY 3592

Query: 3106 EMGTSKEKAKTVTLKQA--LLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLT 3163
                +      + ++    L GHT+ +T       Y I++S SRD TCIIWDLN+L ++ 
Sbjct: 3593 TNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQ 3652

Query: 3164 QLRGHRAPVSALCINELTGDIVSC-----AGTYIHVWSINGNPIVSVNTFTGRSQQIIC- 3217
             L GH++PV+A+  +E +GDI +       G+ + +W++NG+ +  V+      ++IIC 
Sbjct: 3653 SLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVH-----CREIICS 3707

Query: 3218 CCMSEMNEWDTQNVIVTGHSDGVVRFW 3244
               S   E  + NVI  G  +G+VR W
Sbjct: 3708 VAFSNQPEGVSINVIAGGLENGIVRLW 3734



 Score = 33.1 bits (74), Expect = 5.0
 Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 1/46 (2%)

Query: 2341 TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVR 2386
            +  W ++  +L  +R +W  PI  +   W L+ TEGP R R+++ R
Sbjct: 2920 SRHWQELIQQLTHDRAVWYDPI-YYPTSWQLDPTEGPNRERRRLQR 2964


>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
          Length = 2694

 Score =  395 bits (1015), Expect = e-109
 Identities = 251/682 (36%), Positives = 347/682 (50%), Gaps = 91/682 (13%)

Query: 2499 EENQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFG 2558
            E+  +  ++ I    +++E+E+ D    L L+E+         C  +  +D   G L   
Sbjct: 1860 EDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED---------CELITIIDVIPGRLEIT 1910

Query: 2559 KEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVH 2618
             +H Y  DG          D +                            + +  I+E+H
Sbjct: 1911 TQHIYFYDGSIEKEDGVGFDFK----------------------------WPHSQIREIH 1942

Query: 2619 KRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSV 2678
             RRY L+  A+E+F  D  NY L F+K +RNK+Y R L++      S  S  G R    +
Sbjct: 1943 LRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSL-----HSPNSYYGSRSPQEL 1997

Query: 2679 EQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDS 2738
             + SGL          TQ+W   EISNF YL+ +NT+AGR+YNDL QYPVFPWIL DY S
Sbjct: 1998 FKASGL----------TQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 2047

Query: 2739 EEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVAS 2798
            EE+DL NP  FR+L+KP+G   ++     +++Y+++EDP G    +HYGTHYS++  V  
Sbjct: 2048 EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 2107

Query: 2799 YLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLF 2858
            YL+R+EPFT + ++LQ G FD ADR FHS+   W  A   N  DVKELIPEFFY PEFL 
Sbjct: 2108 YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATW-QALMDNPYDVKELIPEFFYFPEFLE 2166

Query: 2859 NSNNFDLGCKQNGTKL-GDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGY 2917
            N N F+LG  Q   +L  DVILP WAK    +FI  HR+ALE +YVSAHLHEWIDLIFGY
Sbjct: 2167 NQNQFNLGRLQISKELVNDVILPKWAK-SAEDFIYKHRKALESEYVSAHLHEWIDLIFGY 2225

Query: 2918 KQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKR 2977
            KQ+GPAAVEA+NVF++  YEG VD+  + D  +  A  G INNFGQ P QL K+PHPP  
Sbjct: 2226 KQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPP-- 2283

Query: 2978 VRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSL-------TPVKELKEPVGQIVCTDK 3030
               RL+ + A        TS    F HL  L+           P+ +   P  Q     +
Sbjct: 2284 ---RLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQY----R 2336

Query: 3031 GILAVEQNKVLIPPTWN---KTFAW-GYADLSCRLGTYESDKAMT----------VYECL 3076
              ++    ++LI  + N    T  W  Y        T+  D+ +T           +   
Sbjct: 2337 SFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPG 2396

Query: 3077 SEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLGHTDTVTCATAS 3136
             E    L  +  + KL+ + G       W+            +   ++ H D VTC    
Sbjct: 2397 LEITSKLFVVSHDAKLLFSAG------YWDNSIQVMSLTKGKIISHIIRHMDIVTCLATD 2450

Query: 3137 LAYHIIVSGSRDRTCIIWDLNK 3158
                 ++SGSRD TC+IW + +
Sbjct: 2451 YCGIHLISGSRDTTCMIWQITQ 2472


>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
          Length = 1404

 Score =  395 bits (1015), Expect = e-109
 Identities = 251/682 (36%), Positives = 347/682 (50%), Gaps = 91/682 (13%)

Query: 2499 EENQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFG 2558
            E+  +  ++ I    +++E+E+ D    L L+E+         C  +  +D   G L   
Sbjct: 570  EDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED---------CELITIIDVIPGRLEIT 620

Query: 2559 KEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVH 2618
             +H Y  DG          D +                            + +  I+E+H
Sbjct: 621  TQHIYFYDGSIEKEDGVGFDFK----------------------------WPHSQIREIH 652

Query: 2619 KRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSV 2678
             RRY L+  A+E+F  D  NY L F+K +RNK+Y R L++      S  S  G R    +
Sbjct: 653  LRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSL-----HSPNSYYGSRSPQEL 707

Query: 2679 EQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDS 2738
             + SGL          TQ+W   EISNF YL+ +NT+AGR+YNDL QYPVFPWIL DY S
Sbjct: 708  FKASGL----------TQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 757

Query: 2739 EEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVAS 2798
            EE+DL NP  FR+L+KP+G   ++     +++Y+++EDP G    +HYGTHYS++  V  
Sbjct: 758  EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 817

Query: 2799 YLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLF 2858
            YL+R+EPFT + ++LQ G FD ADR FHS+   W  A   N  DVKELIPEFFY PEFL 
Sbjct: 818  YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATW-QALMDNPYDVKELIPEFFYFPEFLE 876

Query: 2859 NSNNFDLGCKQNGTKL-GDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGY 2917
            N N F+LG  Q   +L  DVILP WAK    +FI  HR+ALE +YVSAHLHEWIDLIFGY
Sbjct: 877  NQNQFNLGRLQISKELVNDVILPKWAK-SAEDFIYKHRKALESEYVSAHLHEWIDLIFGY 935

Query: 2918 KQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKR 2977
            KQ+GPAAVEA+NVF++  YEG VD+  + D  +  A  G INNFGQ P QL K+PHPP  
Sbjct: 936  KQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPP-- 993

Query: 2978 VRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSL-------TPVKELKEPVGQIVCTDK 3030
               RL+ + A        TS    F HL  L+           P+ +   P  Q     +
Sbjct: 994  ---RLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQY----R 1046

Query: 3031 GILAVEQNKVLIPPTWN---KTFAW-GYADLSCRLGTYESDKAMT----------VYECL 3076
              ++    ++LI  + N    T  W  Y        T+  D+ +T           +   
Sbjct: 1047 SFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPG 1106

Query: 3077 SEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLGHTDTVTCATAS 3136
             E    L  +  + KL+ + G       W+            +   ++ H D VTC    
Sbjct: 1107 LEITSKLFVVSHDAKLLFSAG------YWDNSIQVMSLTKGKIISHIIRHMDIVTCLATD 1160

Query: 3137 LAYHIIVSGSRDRTCIIWDLNK 3158
                 ++SGSRD TC+IW + +
Sbjct: 1161 YCGIHLISGSRDTTCMIWQITQ 1182


>gi|149944548 neurobeachin-like 2 [Homo sapiens]
          Length = 2754

 Score =  395 bits (1014), Expect = e-109
 Identities = 265/732 (36%), Positives = 371/732 (50%), Gaps = 121/732 (16%)

Query: 2506 QDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVI 2565
            +DQ+ E    E E   + A    L E+ EK+     C  V  +    GLL    ++ Y  
Sbjct: 1893 EDQLGEDELAELETPMEAA---ELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFY 1949

Query: 2566 DGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQ 2625
            DG    +T  +   E +  +   P+                       ++EVH RR+ L+
Sbjct: 1950 DG----STERVETEEGIGYDFRRPLA---------------------QLREVHLRRFNLR 1984

Query: 2626 PIAVEVFSGDGRNYLLAF------------------QKG-------IRNKVYQRFLAVVP 2660
              A+E+F  D  NY L F                  Q G       +RN+VY   L + P
Sbjct: 1985 RSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIPPHTQVRNQVYSWLLRLRP 2044

Query: 2661 SLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSY 2720
                 S+     R    + + SGL          TQ+W + EISNF+YLM LNT+AGR+Y
Sbjct: 2045 P----SQGYLSSRSPQEMLRASGL----------TQKWVQREISNFEYLMQLNTIAGRTY 2090

Query: 2721 NDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGE 2780
            NDL QYPVFPW+L DY S  +DL+NP  FR+L+KP+G    +     +++Y+ +EDP G 
Sbjct: 2091 NDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGT 2150

Query: 2781 TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNM 2840
               +HYGTHYS+A  V  YL+R+EPFT + ++LQ G FD +DR FHSV  AW  A   + 
Sbjct: 2151 IDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAW-QARLESP 2209

Query: 2841 ADVKELIPEFFYLPEFLFNSNNFDLGCKQ-NGTKLGDVILPPWAKGDPREFIRVHREALE 2899
            ADVKELIPEFFY P+FL N N FDLGC Q    K+GDV+LPPWA   P +FI+ HR+ALE
Sbjct: 2210 ADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWA-SSPEDFIQQHRQALE 2268

Query: 2900 CDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFIN 2959
             +YVSAHLHEWIDLIFGYKQ+GPAA EA+NVF++  YEG VD+ ++ D  +  A  G I+
Sbjct: 2269 SEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERERKALEGIIS 2328

Query: 2960 NFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR---------- 3009
            NFGQ P QL K+PHP     +RL+ + A   +    T+    F HLD L+          
Sbjct: 2329 NFGQTPCQLLKEPHP-----TRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEVVSDG 2383

Query: 3010 -PSLTPVKELKEPVGQIVCTDKGIL-AVEQNKVLIPPTW-----NKTFAWGYADLSCRLG 3062
             P +  +   ++P   I      +L  V  + +L   +W     N +  + ++     +G
Sbjct: 2384 VPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSK-DPTMG 2442

Query: 3063 TYESDKAMTVYECLSEW-------GQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAK 3115
            ++++ + ++       W       GQ L A+ P+ KL+ +GG       W+         
Sbjct: 2443 SHKTQRLLS-----GPWVPGSGVSGQAL-AVAPDGKLLFSGGH------WDGSLRVTALP 2490

Query: 3116 TVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLT---------QLR 3166
               L   L  H D VTC         ++SGSRD TC++W L     L+          L 
Sbjct: 2491 RGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLY 2550

Query: 3167 GHRAPVSALCIN 3178
            GH A VS + I+
Sbjct: 2551 GHGAAVSCVAIS 2562



 Score = 40.0 bits (92), Expect = 0.041
 Identities = 45/181 (24%), Positives = 72/181 (39%), Gaps = 18/181 (9%)

Query: 3035 VEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVI 3094
            V    + + P     F+ G+ D S R+      K ++   C  +    L A+      +I
Sbjct: 2460 VSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCL-ALDTCGIYLI 2518

Query: 3095 TGGTSTVVCVWEMGTSKEKAKTVTLK--QALLGHTDTVTCATASLAYHIIVSGSRDRTCI 3152
            +G   T   VW +      +  +  K  Q L GH   V+C   S    + VSGS D T I
Sbjct: 2519 SGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSCVAISTELDMAVSGSEDGTVI 2578

Query: 3153 IWDLNKLSFLTQLRGHRA----PVSALCINELTGDIVSCAGTY----------IHVWSIN 3198
            I  + +  F+  LR   A    P+  L +    G IV  +  +          +H++S+N
Sbjct: 2579 IHTVRRGQFVAALRPLGATFPGPIFHLALGS-EGQIVVQSSAWERPGAQVTYSLHLYSVN 2637

Query: 3199 G 3199
            G
Sbjct: 2638 G 2638


>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
          Length = 1335

 Score =  382 bits (982), Expect = e-105
 Identities = 264/729 (36%), Positives = 364/729 (49%), Gaps = 107/729 (14%)

Query: 2499 EENQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFG 2558
            E+  +  ++ I    +++E+E+ D    L L+E+         C  +  +D   G L   
Sbjct: 570  EDKLDLPEEDITARVNVDEKEEQDQKEKLVLMED---------CELITIIDVIPGRLEIT 620

Query: 2559 KEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVH 2618
             +H Y  DG          D +                            + +  I+E+H
Sbjct: 621  TQHIYFYDGSIEKEDGVGFDFK----------------------------WPHSQIREIH 652

Query: 2619 KRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSV 2678
             RRY L+  A+E+F  D  NY L F+K +RNK+Y R L++      S  S  G R    +
Sbjct: 653  LRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSL-----HSPNSYYGSRSPQEL 707

Query: 2679 EQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDS 2738
             + SGL          TQ+W   EISNF YL+ +NT+AGR+YNDL QYPVFPWIL DY S
Sbjct: 708  FKASGL----------TQKWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTS 757

Query: 2739 EEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVAS 2798
            EE+DL NP  FR+L+KP+G   ++     +++Y+++EDP G    +HYGTHYS++  V  
Sbjct: 758  EELDLNNPAVFRDLSKPIGVVNEKNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMH 817

Query: 2799 YLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLF 2858
            YL+R+EPFT + ++LQ G FD ADR FHS+   W  A   N  DVKELIPEFFY PEFL 
Sbjct: 818  YLIRVEPFTTLHIQLQSGRFDCADRQFHSIPATW-QALMDNPYDVKELIPEFFYFPEFLE 876

Query: 2859 NSNNFDLGCKQNGTKL-GDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGY 2917
            N N F+LG  Q   +L  DVILP WAK    +FI  HR+ALE +YVSAHLHEWIDLIFGY
Sbjct: 877  NQNQFNLGRLQISKELVNDVILPKWAK-SAEDFIYKHRKALESEYVSAHLHEWIDLIFGY 935

Query: 2918 KQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKR 2977
            KQ+GPAAVEA+NVF++  YEG VD+  + D  +  A  G INNFGQ P QL K       
Sbjct: 936  KQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLK------- 988

Query: 2978 VRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKELKEPVGQ----IVCTDKGIL 3033
            +   +N        LP   +   +F  + +   ++T  K  +   G     +  T K  +
Sbjct: 989  ITISMNYVIGTHGWLPYDRNISNYFTFIKD--QTVTNPKTQRSINGSFAPGLEITSKLFV 1046

Query: 3034 AVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKA-------MTVYECLSEWGQILCAI 3086
                 K+L        F+ GY D S ++ +    K        M +  CL+      C I
Sbjct: 1047 VSHDAKLL--------FSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLA---TDYCGI 1095

Query: 3087 CPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLK--QALLGHTDTVTCATASLAYHIIVS 3144
                  +I+G   T   +W++         +  K  Q L GHT+ V     S    + VS
Sbjct: 1096 -----HLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVS 1150

Query: 3145 GSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELT----GDIVSCAGT---------- 3190
            GSRD T II  + K  ++  LR        L I  L     G IV  + T          
Sbjct: 1151 GSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKN 1210

Query: 3191 YIHVWSING 3199
             +H++SING
Sbjct: 1211 ALHLFSING 1219


>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
            containing [Homo sapiens]
          Length = 2863

 Score =  365 bits (938), Expect = e-100
 Identities = 221/576 (38%), Positives = 310/576 (53%), Gaps = 67/576 (11%)

Query: 2611 YEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVS 2670
            + +I+ +  RRYLLQ  A+E+F              + N+V   F    P+     + V 
Sbjct: 2135 FTEIRSIFSRRYLLQNTALEIF--------------MANRVAVMFNFPDPATV---KKVV 2177

Query: 2671 GQRPNTSVEQGSGLLST----------LVGEKSVTQRWERGEISNFQYLMHLNTLAGRSY 2720
               P   V    GL  T          L    ++TQRW+  EISNF+YLM LNT+AGRSY
Sbjct: 2178 NYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSY 2237

Query: 2721 NDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGE 2780
            NDL QYPVFPW++ +Y+SEE+DLT P  FR+L+KP+GA   +R A + +RY+ WED   +
Sbjct: 2238 NDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWED--DQ 2295

Query: 2781 TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNM 2840
             P +HYGTHYS+A  V ++L+R+EPFT  FL LQGG FD ADR F S+  AW + S+ + 
Sbjct: 2296 VPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRN-SQRDT 2354

Query: 2841 ADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALEC 2900
            +D+KELIPEF+YLPE   N NN++LG   +GT + DV LPPWAK    EF+ ++R ALE 
Sbjct: 2355 SDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAK-TSEEFVHINRLALES 2413

Query: 2901 DYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINN 2960
            ++VS  LH+WIDLIFGYKQQGP AV A+NVF++L YEG V++ +I DP+   A    I +
Sbjct: 2414 EFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRS 2473

Query: 2961 FGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR-PSLTPVKELK 3019
            FGQ P QL  +PHPP+          + + V P   +DK     +  L+ PS +PV  + 
Sbjct: 2474 FGQTPSQLLIEPHPPR---------GSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVA 2524

Query: 3020 EPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYAD--------------LSCRLGTYE 3065
                  + T   ++ V  N++     W+   A   A               ++   G + 
Sbjct: 2525 ANTQPGLAT-PAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHR 2583

Query: 3066 SDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLG 3125
                  + + +    Q       N  +++ G        W+         T  L Q + G
Sbjct: 2584 RQITDLLDQSIQVHSQCFVITSDNRYILVCG-------FWDKSFRVYSTDTGRLIQVVFG 2636

Query: 3126 HTDTVTCATASLAY----HIIVSGSRDRTCIIWDLN 3157
            H D VTC   S +Y      I+SGSRD T ++W  N
Sbjct: 2637 HWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWN 2672



 Score = 37.0 bits (84), Expect = 0.35
 Identities = 24/137 (17%), Positives = 50/137 (36%), Gaps = 22/137 (16%)

Query: 3032 ILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPK 3091
            ++  +   +L+   W+K+F             Y +D    +      W  + C       
Sbjct: 2602 VITSDNRYILVCGFWDKSFR-----------VYSTDTGRLIQVVFGHWDVVTCLARSESY 2650

Query: 3092 L-----VITGGTSTVVCVWEMGTS------KEKAKTVTLKQALLGHTDTVTCATASLAYH 3140
            +     +++G     + +W              ++T   +  L GH   VTCA       
Sbjct: 2651 IGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELG 2710

Query: 3141 IIVSGSRDRTCIIWDLN 3157
            +++SGS++  C+I  +N
Sbjct: 2711 LVLSGSQEGPCLIHSMN 2727


>gi|62422577 neurobeachin [Homo sapiens]
          Length = 2946

 Score =  359 bits (922), Expect = 2e-98
 Identities = 219/561 (39%), Positives = 313/561 (55%), Gaps = 35/561 (6%)

Query: 2611 YEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAF--QKGIRNKVYQRFLAVVPSLTDSSES 2668
            + +I+ V  RRYLLQ  A+EVF  +  + +  F  Q  ++  VY      +P +   +  
Sbjct: 2209 FSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYS-----LPRVGVGTSY 2263

Query: 2669 VSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPV 2728
               Q    S+     L  +     ++TQRW+R EISNF+YLM LNT+AGR+YNDL QYPV
Sbjct: 2264 GLPQARRISLATPRQLYKS----SNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPV 2319

Query: 2729 FPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGT 2788
            FPW+L +Y+SEE+DLT P  FR+L+KP+GA   +R   Y +RY+ WED   ++P YHY T
Sbjct: 2320 FPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWED--DQSPPYHYNT 2377

Query: 2789 HYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIP 2848
            HYS+A    S+LVR+EPFT  FL    G FD  DR F SV  +W   S+ + +DVKELIP
Sbjct: 2378 HYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSW-RTSQRDTSDVKELIP 2436

Query: 2849 EFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLH 2908
            EF+YLPE   NSN ++LG +++   + DV LPPWAK  P +F+R++R ALE ++VS  LH
Sbjct: 2437 EFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLH 2495

Query: 2909 EWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQL 2968
            +WIDLIFGYKQ+GP AV A+NVFH+L YEG V++ +I DP+   A    I NFGQ P QL
Sbjct: 2496 QWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQL 2555

Query: 2969 FKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLR-PSLTPVKELKEPVGQIVC 3027
              +PHPP+     L      +   P    D++    +  L+ PS +PV  +       + 
Sbjct: 2556 LIEPHPPRSSAMHL----CFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHL- 2610

Query: 3028 TDKGILAVEQNKVLIPPTWNKTF----AWGYA-----DLSCRLGTYESDKAMTVYECLSE 3078
            T   ++ V  +++     W+ T     A GY+      L   +    ++ +      +++
Sbjct: 2611 TIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITD 2670

Query: 3079 WGQILCAICPNPKLVITGGTSTVVC-VWEMGTSKEKAKTVTLKQALLGHTDTVTCATASL 3137
                   I  +  +V       ++C  W+        +T  L Q + GH D VTC   S 
Sbjct: 2671 LVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSE 2730

Query: 3138 AY----HIIVSGSRDRTCIIW 3154
            +Y      IVSGSRD T ++W
Sbjct: 2731 SYIGGDCYIVSGSRDATLLLW 2751



 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 65/346 (18%), Positives = 125/346 (36%), Gaps = 65/346 (18%)

Query: 1192 QWHHLVLVMSKGMLKNSTAALYIDGQLVNTVKLHYVHSTPGGSGSANPPVVSTVYAYIGT 1251
            +W+ + +V      +NS    Y++GQLV+   + +  +T                 ++G+
Sbjct: 324  KWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKC----------FLGS 373

Query: 1252 PPAQRQIASLVWRLGPTHFLEEVLPSSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVP 1311
                        +LG  +   E L  + +  I++LGP Y  +F+         KSE    
Sbjct: 374  SETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFK--------FKSE---- 421

Query: 1312 SPVSLVPEEKVSFGLYALSVSSLTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHN 1371
            S + L    K                        L    +A  +  + +  AT  +L   
Sbjct: 422  SDIHLAEHHK----------------------QVLYDGKLASSIAFTYNAKATDAQLCLE 459

Query: 1372 SAGHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAV 1431
            S+   N S        +    V+  V   + + +  +GG   +  L A   + +   + V
Sbjct: 460  SSPKENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQV 519

Query: 1432 KALVC---------VVKSNPLASKEMERIKGYQLLAMLLKK-KRSLLNSHILHLTFSLVG 1481
            +  VC         ++KS+    ++M   KG+ ++  LL+K  R  +   +L    S   
Sbjct: 520  ETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAK 579

Query: 1482 TVDSGHETSIIPNSTAFQDLLCDF-----EVWLHAPYELHLSLFEH 1522
             +D       + +       LCD       +W+H P ++ LSL+ +
Sbjct: 580  YLDG------LSHGAPLLKQLCDHILFNPAIWIHTPAKVQLSLYTY 619


>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
            factor isoform 1 [Homo sapiens]
          Length = 917

 Score =  294 bits (753), Expect = 9e-79
 Identities = 231/717 (32%), Positives = 332/717 (46%), Gaps = 117/717 (16%)

Query: 2612 EDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSG 2671
            +D++ ++KRR+ L P+ +EVF           +  + + +Y +F    P   D       
Sbjct: 238  QDVRRIYKRRHGLMPLGLEVF---------CTEDDLCSDIYLKFYE--PQDRDDLYFYIA 286

Query: 2672 QRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPW 2731
                  V + +         +S   +W+RG +SN+QYL+HLN LA RS NDL QYPVFPW
Sbjct: 287  TYLEHHVAEHTA--------ESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPW 338

Query: 2732 ILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYS 2791
            I+ DY S E+DL+NP TFR+L+KP+GA   ERL +   RY++  +P      + YG+HYS
Sbjct: 339  IIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK-----FMYGSHYS 393

Query: 2792 SAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFF 2851
            S   V  YLVR+ P  +  L LQ G FD ADRMF+S+ E W +       D KELIPEF+
Sbjct: 394  SPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLD-GATDFKELIPEFY 450

Query: 2852 YLP-EFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEW 2910
                 FL NS   DLG +Q G  + DV LPPWA   P +F++  ++ALE +YVS HLHEW
Sbjct: 451  GDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEW 509

Query: 2911 IDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFK 2970
            IDLIFGYKQ+G  AV A NVFH L YEG VD+ +I DP ++ A +  I  FGQ PKQLF 
Sbjct: 510  IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV 569

Query: 2971 KPHP----PK-RVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKELKEPVGQI 3025
             PHP    PK +  S+ +  NA ++  PG  S +        L  +     +L E     
Sbjct: 570  TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH 629

Query: 3026 VCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECL--------- 3076
                 GI        +   + + T    ++  S  L    S   M +  CL         
Sbjct: 630  KEAVTGITVSRNGSSVFTTSQDSTLKM-FSKESKMLQRSISFSNMALSSCLLLPGDATVI 688

Query: 3077 -SEW---------------------GQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKA 3114
             S W                        +  IC +   + +    + V VW  G   E  
Sbjct: 689  TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS-GVPAEMP 747

Query: 3115 KTVTLKQALLG---HTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAP 3171
             T      LL    H  +V   + + A  ++VSG+++ T  IWDL   + + Q+  H   
Sbjct: 748  GTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGI 807

Query: 3172 VSAL----------------CINEL---TGDIVSCAGT----YIHVWSINGNPIVS---- 3204
            V                   C+N +   TG ++S   +       VW  +GN ++S    
Sbjct: 808  VCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQS 865

Query: 3205 -------------VNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEF 3248
                              G +  + C  M+E       + I+TG  D  + FW++++
Sbjct: 866  GELLVWDLLGAKISERIQGHTGAVTCIWMNEQ-----CSSIITGGEDRQIIFWKLQY 917


>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
            factor isoform 2 [Homo sapiens]
          Length = 948

 Score =  294 bits (753), Expect = 9e-79
 Identities = 231/717 (32%), Positives = 332/717 (46%), Gaps = 117/717 (16%)

Query: 2612 EDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSG 2671
            +D++ ++KRR+ L P+ +EVF           +  + + +Y +F    P   D       
Sbjct: 269  QDVRRIYKRRHGLMPLGLEVF---------CTEDDLCSDIYLKFYE--PQDRDDLYFYIA 317

Query: 2672 QRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPW 2731
                  V + +         +S   +W+RG +SN+QYL+HLN LA RS NDL QYPVFPW
Sbjct: 318  TYLEHHVAEHTA--------ESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPW 369

Query: 2732 ILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYS 2791
            I+ DY S E+DL+NP TFR+L+KP+GA   ERL +   RY++  +P      + YG+HYS
Sbjct: 370  IIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK-----FMYGSHYS 424

Query: 2792 SAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFF 2851
            S   V  YLVR+ P  +  L LQ G FD ADRMF+S+ E W +       D KELIPEF+
Sbjct: 425  SPGYVLFYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCLD-GATDFKELIPEFY 481

Query: 2852 YLP-EFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEW 2910
                 FL NS   DLG +Q G  + DV LPPWA   P +F++  ++ALE +YVS HLHEW
Sbjct: 482  GDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEW 540

Query: 2911 IDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFK 2970
            IDLIFGYKQ+G  AV A NVFH L YEG VD+ +I DP ++ A +  I  FGQ PKQLF 
Sbjct: 541  IDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFV 600

Query: 2971 KPHP----PK-RVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKELKEPVGQI 3025
             PHP    PK +  S+ +  NA ++  PG  S +        L  +     +L E     
Sbjct: 601  TPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIH 660

Query: 3026 VCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECL--------- 3076
                 GI        +   + + T    ++  S  L    S   M +  CL         
Sbjct: 661  KEAVTGITVSRNGSSVFTTSQDSTLKM-FSKESKMLQRSISFSNMALSSCLLLPGDATVI 719

Query: 3077 -SEW---------------------GQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKA 3114
             S W                        +  IC +   + +    + V VW  G   E  
Sbjct: 720  TSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWS-GVPAEMP 778

Query: 3115 KTVTLKQALLG---HTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAP 3171
             T      LL    H  +V   + + A  ++VSG+++ T  IWDL   + + Q+  H   
Sbjct: 779  GTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGI 838

Query: 3172 VSAL----------------CINEL---TGDIVSCAGT----YIHVWSINGNPIVS---- 3204
            V                   C+N +   TG ++S   +       VW  +GN ++S    
Sbjct: 839  VCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVW--DGNSVLSGSQS 896

Query: 3205 -------------VNTFTGRSQQIICCCMSEMNEWDTQNVIVTGHSDGVVRFWRMEF 3248
                              G +  + C  M+E       + I+TG  D  + FW++++
Sbjct: 897  GELLVWDLLGAKISERIQGHTGAVTCIWMNEQ-----CSSIITGGEDRQIIFWKLQY 948


>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
          Length = 1941

 Score =  100 bits (249), Expect = 3e-20
 Identities = 97/301 (32%), Positives = 123/301 (40%), Gaps = 71/301 (23%)

Query: 2692 KSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPK-TFR 2750
            +S+   W  G ISNF YLM LN LAGR   D   +PV PW+        VD T P   FR
Sbjct: 346  RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWV--------VDFTTPHGRFR 397

Query: 2751 NLAKPM------GAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLV--- 2801
            +L K          Q D      ++ +       GE P  H   H S  +   +Y V   
Sbjct: 398  DLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPP--HVPHHISDVLSDITYYVYKA 455

Query: 2802 RMEPFTQIFLRLQGGHFDLADRMFHSVREAW----YSASKHNMAD--VKELIPEFFYLPE 2855
            R  P + +      GH          VR  W    Y AS   M +    E IPEF+  P 
Sbjct: 456  RRTPRSVLC-----GH----------VRAQWEPHEYPASMERMQNWTPDECIPEFYTDPS 500

Query: 2856 FLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIF 2915
             +F S + D+          D+ +P W     +EF+  HR  LE   VS  LH WIDL F
Sbjct: 501  -IFRSIHPDMP---------DLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTF 549

Query: 2916 GYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPP 2975
            GYK QG  AV+  NV  HL            D     A+ G +        QLF +PHP 
Sbjct: 550  GYKLQGKEAVKEKNVCLHLV-----------DAHTHLASYGVV--------QLFDQPHPQ 590

Query: 2976 K 2976
            +
Sbjct: 591  R 591



 Score = 36.2 bits (82), Expect = 0.59
 Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 13/102 (12%)

Query: 3105 WEMGTSKEKAK----TVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLS 3160
            +E+G S++ A      + L Q+  GH+  V C     +    +SGS+DRT  +W L    
Sbjct: 1623 YEIGVSQQDAHFHFHQIRL-QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYG 1681

Query: 3161 FLTQ-------LRGHRAPVSALCINELTGDIVSCAGTYIHVW 3195
              T           HR  V  +   E    +VSC G  +HVW
Sbjct: 1682 DGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGA-VHVW 1722


>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
          Length = 2240

 Score =  100 bits (249), Expect = 3e-20
 Identities = 97/301 (32%), Positives = 123/301 (40%), Gaps = 71/301 (23%)

Query: 2692 KSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPK-TFR 2750
            +S+   W  G ISNF YLM LN LAGR   D   +PV PW+        VD T P   FR
Sbjct: 645  RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWV--------VDFTTPHGRFR 696

Query: 2751 NLAKPM------GAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLV--- 2801
            +L K          Q D      ++ +       GE P  H   H S  +   +Y V   
Sbjct: 697  DLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPP--HVPHHISDVLSDITYYVYKA 754

Query: 2802 RMEPFTQIFLRLQGGHFDLADRMFHSVREAW----YSASKHNMAD--VKELIPEFFYLPE 2855
            R  P + +      GH          VR  W    Y AS   M +    E IPEF+  P 
Sbjct: 755  RRTPRSVLC-----GH----------VRAQWEPHEYPASMERMQNWTPDECIPEFYTDPS 799

Query: 2856 FLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIF 2915
             +F S + D+          D+ +P W     +EF+  HR  LE   VS  LH WIDL F
Sbjct: 800  -IFRSIHPDMP---------DLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTF 848

Query: 2916 GYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPP 2975
            GYK QG  AV+  NV  HL            D     A+ G +        QLF +PHP 
Sbjct: 849  GYKLQGKEAVKEKNVCLHLV-----------DAHTHLASYGVV--------QLFDQPHPQ 889

Query: 2976 K 2976
            +
Sbjct: 890  R 890



 Score = 36.2 bits (82), Expect = 0.59
 Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 13/102 (12%)

Query: 3105 WEMGTSKEKAK----TVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLS 3160
            +E+G S++ A      + L Q+  GH+  V C     +    +SGS+DRT  +W L    
Sbjct: 1922 YEIGVSQQDAHFHFHQIRL-QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYG 1980

Query: 3161 FLTQ-------LRGHRAPVSALCINELTGDIVSCAGTYIHVW 3195
              T           HR  V  +   E    +VSC G  +HVW
Sbjct: 1981 DGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGA-VHVW 2021


>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
          Length = 1941

 Score =  100 bits (249), Expect = 3e-20
 Identities = 97/301 (32%), Positives = 123/301 (40%), Gaps = 71/301 (23%)

Query: 2692 KSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPK-TFR 2750
            +S+   W  G ISNF YLM LN LAGR   D   +PV PW+        VD T P   FR
Sbjct: 346  RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWV--------VDFTTPHGRFR 397

Query: 2751 NLAKPM------GAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLV--- 2801
            +L K          Q D      ++ +       GE P  H   H S  +   +Y V   
Sbjct: 398  DLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPP--HVPHHISDVLSDITYYVYKA 455

Query: 2802 RMEPFTQIFLRLQGGHFDLADRMFHSVREAW----YSASKHNMAD--VKELIPEFFYLPE 2855
            R  P + +      GH          VR  W    Y AS   M +    E IPEF+  P 
Sbjct: 456  RRTPRSVLC-----GH----------VRAQWEPHEYPASMERMQNWTPDECIPEFYTDPS 500

Query: 2856 FLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIF 2915
             +F S + D+          D+ +P W     +EF+  HR  LE   VS  LH WIDL F
Sbjct: 501  -IFRSIHPDMP---------DLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTF 549

Query: 2916 GYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPP 2975
            GYK QG  AV+  NV  HL            D     A+ G +        QLF +PHP 
Sbjct: 550  GYKLQGKEAVKEKNVCLHLV-----------DAHTHLASYGVV--------QLFDQPHPQ 590

Query: 2976 K 2976
            +
Sbjct: 591  R 591



 Score = 36.2 bits (82), Expect = 0.59
 Identities = 30/102 (29%), Positives = 44/102 (43%), Gaps = 13/102 (12%)

Query: 3105 WEMGTSKEKAK----TVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLS 3160
            +E+G S++ A      + L Q+  GH+  V C     +    +SGS+DRT  +W L    
Sbjct: 1623 YEIGVSQQDAHFHFHQIRL-QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYG 1681

Query: 3161 FLTQ-------LRGHRAPVSALCINELTGDIVSCAGTYIHVW 3195
              T           HR  V  +   E    +VSC G  +HVW
Sbjct: 1682 DGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGA-VHVW 1722


>gi|217272865 myotubularin related protein 4 [Homo sapiens]
          Length = 1195

 Score = 73.2 bits (178), Expect = 4e-12
 Identities = 50/172 (29%), Positives = 71/172 (41%), Gaps = 24/172 (13%)

Query: 3367 PHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFD-RKDNAHPAE--------VTALG 3417
            P P  +      +++ GY+ E + + R    +    D R   A PAE         T L 
Sbjct: 1015 PFPTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLK 1074

Query: 3418 IS---------KDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFS 3468
             S          DHS   + ++     SW   D+   +    WV D     C  C   F 
Sbjct: 1075 ESDGSDTEDFGSDHSEDCLSEA-----SWEPVDKK-ETEVTRWVPDHMASHCYNCDCEFW 1128

Query: 3469 LTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERGSE 3520
            L +RRHHCRNCG +FC  C   +  I   ++  PV VC +CY ++Q  R  E
Sbjct: 1129 LAKRRHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARE 1180


>gi|55741864 zinc finger, FYVE domain containing 28 [Homo sapiens]
          Length = 887

 Score = 70.1 bits (170), Expect = 4e-11
 Identities = 26/60 (43%), Positives = 37/60 (61%)

Query: 3451 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
            WV DE    C+ C   F++  R+HHCR+CG++FC +CS   + + R     PVRVC +CY
Sbjct: 814  WVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCY 873


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sapiens]
          Length = 600

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 42/160 (26%), Positives = 72/160 (45%), Gaps = 17/160 (10%)

Query: 3352 SEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPA 3411
            SE + R  LQ  L H       +R   +   G + E + +   K  +    + ++ A   
Sbjct: 445  SEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA--- 501

Query: 3412 EVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADH-WVKDEGGDSCSGCSVRFSLT 3470
             +  +G+    S++ + D +          +  ++   H W+KD+    C  C   FS++
Sbjct: 502  -LQEMGLHLSQSKLKMEDIK----------EVNQALKGHAWLKDDEATHCRQCEKEFSIS 550

Query: 3471 ERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
             R+HHCRNCG +FC  CS   +E+       PVRVC +C+
Sbjct: 551  RRKHHCRNCGHIFCNTCS--SNELALPSYPKPVRVCDSCH 588


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sapiens]
          Length = 600

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 42/160 (26%), Positives = 72/160 (45%), Gaps = 17/160 (10%)

Query: 3352 SEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPA 3411
            SE + R  LQ  L H       +R   +   G + E + +   K  +    + ++ A   
Sbjct: 445  SEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA--- 501

Query: 3412 EVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADH-WVKDEGGDSCSGCSVRFSLT 3470
             +  +G+    S++ + D +          +  ++   H W+KD+    C  C   FS++
Sbjct: 502  -LQEMGLHLSQSKLKMEDIK----------EVNQALKGHAWLKDDEATHCRQCEKEFSIS 550

Query: 3471 ERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
             R+HHCRNCG +FC  CS   +E+       PVRVC +C+
Sbjct: 551  RRKHHCRNCGHIFCNTCS--SNELALPSYPKPVRVCDSCH 588


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sapiens]
          Length = 708

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 42/160 (26%), Positives = 72/160 (45%), Gaps = 17/160 (10%)

Query: 3352 SEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPA 3411
            SE + R  LQ  L H       +R   +   G + E + +   K  +    + ++ A   
Sbjct: 553  SEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA--- 609

Query: 3412 EVTALGISKDHSRILVGDSRGRVFSWSVSDQPGRSAADH-WVKDEGGDSCSGCSVRFSLT 3470
             +  +G+    S++ + D +          +  ++   H W+KD+    C  C   FS++
Sbjct: 610  -LQEMGLHLSQSKLKMEDIK----------EVNQALKGHAWLKDDEATHCRQCEKEFSIS 658

Query: 3471 ERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
             R+HHCRNCG +FC  CS   +E+       PVRVC +C+
Sbjct: 659  RRKHHCRNCGHIFCNTCS--SNELALPSYPKPVRVCDSCH 696


>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
            sapiens]
          Length = 641

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 27/60 (45%), Positives = 38/60 (63%), Gaps = 2/60 (3%)

Query: 3451 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
            W+KD+    C  C   FSL++R+HHCRNCG++FC  CS   +E+       PVRVC +C+
Sbjct: 572  WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACS--DNELPLPSSPKPVRVCDSCH 629


>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
            substrate [Homo sapiens]
          Length = 777

 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 31/69 (44%), Positives = 38/69 (55%), Gaps = 3/69 (4%)

Query: 3448 ADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQ 3507
            A  WV  E    C  C V+F +  R+HHCR CGQ+FC KCS   S I +  I   VRVC+
Sbjct: 157  APDWVDAE---ECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCE 213

Query: 3508 NCYYNLQHE 3516
             CY  L  +
Sbjct: 214  PCYEQLNRK 222


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 31/72 (43%), Positives = 42/72 (58%), Gaps = 1/72 (1%)

Query: 3443 PGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSP 3502
            P  S A  W+ D     C  C+  F+LT RRHHCR CG++ CQ CS  +  +  LK + P
Sbjct: 1211 PLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLK-NQP 1269

Query: 3503 VRVCQNCYYNLQ 3514
             RVC++C+  LQ
Sbjct: 1270 ARVCEHCFQELQ 1281


>gi|153791377 apoptosis-inducing protein D [Homo sapiens]
          Length = 279

 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 33/80 (41%), Positives = 43/80 (53%), Gaps = 2/80 (2%)

Query: 3443 PGRSAADHWVKDEGGDSCSGCS-VRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISS 3501
            P    A  W+ D+  D C  C+  RFS   RRHHCR CG + C +CSR +  + RL    
Sbjct: 141  PSTEHAAPWIPDKATDICMRCTQTRFSALTRRHHCRKCGFVVCAECSRQRFLLPRLS-PK 199

Query: 3502 PVRVCQNCYYNLQHERGSED 3521
            PVRVC  CY  L  ++  E+
Sbjct: 200  PVRVCSLCYRELAAQQRQEE 219


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 25/54 (46%), Positives = 35/54 (64%)

Query: 3457 GDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
            G  C  C+ RF +T R+HHCR+CG+L C KCS  +  I +  ++ PVRVC  C+
Sbjct: 1108 GSYCYECTARFGVTTRKHHCRHCGRLLCHKCSTKEIPIIKFDLNKPVRVCNICF 1161


>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
          Length = 1161

 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 27/78 (34%), Positives = 37/78 (47%)

Query: 3444 GRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPV 3503
            G      W+ D     C  C   F L  R+HHCRNCG +FC  C   +  +   ++  P 
Sbjct: 1072 GDEVMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPS 1131

Query: 3504 RVCQNCYYNLQHERGSED 3521
            RVC++CY +L     S D
Sbjct: 1132 RVCKSCYSSLHPTSSSID 1149


>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
          Length = 1198

 Score = 64.7 bits (156), Expect = 2e-09
 Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 1/86 (1%)

Query: 3436 SWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIK 3495
            SW   D+        W+ D     C  C   F L  R+HHCRNCG +FC  C   +  + 
Sbjct: 1102 SWEQVDKQDTEMT-RWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVP 1160

Query: 3496 RLKISSPVRVCQNCYYNLQHERGSED 3521
              ++  P RVC++CY +L     S D
Sbjct: 1161 SQQLFEPSRVCKSCYSSLHPTSSSID 1186


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 28/64 (43%), Positives = 36/64 (56%), Gaps = 2/64 (3%)

Query: 3451 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
            W +D    +C  C   FS+T RRHHCR CG +FC +CS   +     K   PVRVC  C+
Sbjct: 1349 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACF 1406

Query: 3511 YNLQ 3514
             +LQ
Sbjct: 1407 NDLQ 1410


>gi|157426866 zinc finger, FYVE domain containing 16 [Homo sapiens]
          Length = 1539

 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 26/70 (37%), Positives = 39/70 (55%), Gaps = 2/70 (2%)

Query: 3451 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCY 3510
            WV D    +C  C V+F+ T+RRHHCR CG++FC  C   + +++ L+     RVC  CY
Sbjct: 744  WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLE--KEARVCVVCY 801

Query: 3511 YNLQHERGSE 3520
              +   +  E
Sbjct: 802  ETISKAQAFE 811


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 135,836,169
Number of Sequences: 37866
Number of extensions: 6252256
Number of successful extensions: 20982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 19779
Number of HSP's gapped (non-prelim): 1116
length of query: 3526
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3404
effective length of database: 13,627,866
effective search space: 46389255864
effective search space used: 46389255864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.