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Search of human proteins with 31317252
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform
2 [Homo sapiens]
(487 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform ... 955 0.0
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 897 0.0
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 73 7e-13
gi|55770876 notch4 preproprotein [Homo sapiens] 71 2e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 70 3e-12
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo... 67 3e-11
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 66 8e-11
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 66 8e-11
gi|134244285 Notch homolog 3 [Homo sapiens] 65 1e-10
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 64 4e-10
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 64 4e-10
gi|148833508 notch1 preproprotein [Homo sapiens] 63 5e-10
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 63 5e-10
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 63 5e-10
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 63 5e-10
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 63 5e-10
gi|24041035 notch 2 preproprotein [Homo sapiens] 62 2e-09
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 61 2e-09
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 61 2e-09
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 61 2e-09
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 61 2e-09
gi|34304381 inversin isoform a [Homo sapiens] 61 3e-09
gi|34304379 inversin isoform b [Homo sapiens] 61 3e-09
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 60 3e-09
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 60 6e-09
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 60 6e-09
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 60 6e-09
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 60 6e-09
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 60 6e-09
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 60 6e-09
>gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform 2
[Homo sapiens]
Length = 487
Score = 955 bits (2469), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD
Sbjct: 1 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
Query: 61 LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW
Sbjct: 61 LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
Query: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
Sbjct: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
Query: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE
Sbjct: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
Query: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG
Sbjct: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
Query: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
Sbjct: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
Query: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV
Sbjct: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
Query: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGKARASRRGDAGVCRRQEMACKC 480
NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGKARASRRGDAGVCRRQEMACKC
Sbjct: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGKARASRRGDAGVCRRQEMACKC 480
Query: 481 LHPKFRN 487
LHPKFRN
Sbjct: 481 LHPKFRN 487
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 897 bits (2319), Expect = 0.0
Identities = 461/469 (98%), Positives = 461/469 (98%)
Query: 1 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD
Sbjct: 1 MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
Query: 61 LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW
Sbjct: 61 LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
Query: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
Sbjct: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
Query: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE
Sbjct: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
Query: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG
Sbjct: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
Query: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
Sbjct: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
Query: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV
Sbjct: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
Query: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGKARASRRGDAG 469
NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATG R AG
Sbjct: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAG 469
Score = 75.1 bits (183), Expect = 1e-13
Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 26/166 (15%)
Query: 253 DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGW----SLLHKGIQRGDLFAATFL 308
D G+ L LAL+ LE IA+TLV H D +LLH+ I + A FL
Sbjct: 686 DEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFL 745
Query: 309 IKNGAFVNAATL------GAQE-----TPLHLVALYSSKKHSADVMSEMAQIAEALLQAG 357
I++G VN+ G +E TPLHL A + + + + LL+ G
Sbjct: 746 IRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWG-----------LEETVQCLLEFG 794
Query: 358 ANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST 403
AN N QD++GRTP+HV+I + + + L+ + L ++D +G T
Sbjct: 795 ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT 840
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/176 (27%), Positives = 79/176 (44%), Gaps = 19/176 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEA--------DHNGDLALDLALSRRLESIA 272
PLH AI DVV + L + + L N D L LAL + +IA
Sbjct: 546 PLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIA 605
Query: 273 TTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVAL 332
L+ A ++ G +LLH IQR D +A FL+++ A +N + ET L L
Sbjct: 606 AQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLA-- 663
Query: 333 YSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
+ +++ + +A+ GA+ ++ D KG PL +++ E + S L++
Sbjct: 664 ---------IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVR 710
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/252 (28%), Positives = 93/252 (36%), Gaps = 71/252 (28%)
Query: 213 MIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRL---- 268
M SK PLH +I E VF L++ QL +L DH G AL LA+
Sbjct: 362 MQDSKGRTPLHVSIMAGNE-YVFSQLLQC-KQLDLELK--DHEGSTALWLAVQHITVSSD 417
Query: 269 -------------------ESIATTLVSHKADVDMVDKS-GWSLLHKGIQRGDLFAATFL 308
S A L+ + D D + G LL + G+ AA FL
Sbjct: 418 QSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFL 477
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG- 367
NGA VN ETPLH + +A + LLQ GANPN+Q +
Sbjct: 478 ATNGAHVNHRNKWG-ETPLHTACRHG-----------LANLTAELLQQGANPNLQTEEAL 525
Query: 368 ------------------RTPLHVSIMAGNEYVFSQLLQCKQ------------LDLELK 397
+TPLH++I + V S +L+ K D LK
Sbjct: 526 PLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLK 585
Query: 398 DHEGSTALWLAV 409
D T L LA+
Sbjct: 586 DSRDQTVLGLAL 597
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/159 (25%), Positives = 70/159 (44%), Gaps = 11/159 (6%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A++ E +V L+ K+NE + AL LA + L +I + L+ +
Sbjct: 910 PLHLAVQAGSEIIVRNLLLA-----GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
D VD++G + LH + G L L+ A ++PLH++ Y K+++A
Sbjct: 965 DFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQY-GKENAA 1023
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGN 379
+ + G + D+ G T L ++ M GN
Sbjct: 1024 AIFDLFLE-----CMPGYPLDKPDADGSTVLLLAYMKGN 1057
Score = 44.3 bits (103), Expect = 3e-04
Identities = 61/251 (24%), Positives = 88/251 (35%), Gaps = 43/251 (17%)
Query: 222 LHKAIKVEREDVV-FLYLIEMDSQLP------GKLNEADHNGDLALDLALSRRLESIATT 274
LH+AI E FL D P G+ E +G L LA S LE
Sbjct: 730 LHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQC 789
Query: 275 LVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYS 334
L+ A+V+ D G + +H I L+ + TP +
Sbjct: 790 LLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFK 849
Query: 335 SKKHSADVMSEMAQIAEAL-------------------------LQAGANPNMQDSKGRT 369
+ K + ++ + AE + + A N +QD+ T
Sbjct: 850 NNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLT 909
Query: 370 PLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVV 429
PLH+++ AG+E + LL EL H TAL LA Q Q + V +
Sbjct: 910 PLHLAVQAGSEIIVRNLLLAGAKVNELTKHR-QTALHLAAQ-------QDLPTICSVLLE 961
Query: 430 NGTSF---DEN 437
NG F DEN
Sbjct: 962 NGVDFAAVDEN 972
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 72.8 bits (177), Expect = 7e-13
Identities = 59/210 (28%), Positives = 99/210 (47%), Gaps = 24/210 (11%)
Query: 221 PLHKAI---KVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVS 277
PLH + VE+ ++ + +++D Q +G L +A + + L++
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTA--------SGYTPLLIAAQDQQPDLCALLLA 416
Query: 278 HKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK 337
H AD + VD+ GW+ LH Q GD A L+ +GA V+A TPLHL A
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW-TPLHLAA------ 469
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+ +A L+ A+PN+ +++G+TPLHV+ G+ + +LL + +L+ +
Sbjct: 470 -----QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV-KLLTSQGAELDAQ 523
Query: 398 DHEGSTALWLAVQHITVSSDQSVNPFEDVP 427
T L LAV+ V + Q + VP
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/179 (30%), Positives = 76/179 (42%), Gaps = 13/179 (7%)
Query: 238 LIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGI 297
L+++ + +L+ N L LA+ R L+ A D +D+SG+ LH
Sbjct: 509 LVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568
Query: 298 QRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAG 357
RG L++ GA + T TPLHL A K H +I L ++
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGW-TPLHLAAY---KGH--------LEIIHLLAESH 616
Query: 358 ANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSS 416
AN + TPLH++ G E V S LLQC D + G T L LAVQ T S
Sbjct: 617 ANMGALGAVNWTPLHLAARHGEEAVVSALLQC-GADPNAAEQSGWTPLHLAVQRSTFLS 674
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 12/127 (9%)
Query: 260 LDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT 319
L LA E++ + L+ AD + ++SGW+ LH +QR + L+++ A V+A
Sbjct: 630 LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN 689
Query: 320 LGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGN 379
TP HL AL + I + L++AGA ++QD TPL +++ +
Sbjct: 690 -KVGWTPAHLAALKGN-----------TAILKVLVEAGAQLDVQDGVSCTPLQLALRSRK 737
Query: 380 EYVFSQL 386
+ + S L
Sbjct: 738 QGIMSFL 744
Score = 50.8 bits (120), Expect = 3e-06
Identities = 58/224 (25%), Positives = 88/224 (39%), Gaps = 53/224 (23%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A VER V + + +P L D +G L A +R I L+ + A
Sbjct: 530 PLHLA--VERGKVRAIQHLLKSGAVPDAL---DQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE-TPLHLVALYSSKKHS 339
+++ GW+ LH +G L L ++ A N LGA TPLHL A + +
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA--NMGALGAVNWTPLHLAARHGEEA-- 640
Query: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS------------------------- 374
+ ALLQ GA+PN + G TPLH++
Sbjct: 641 ---------VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
Query: 375 --------IMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ 410
+ GN + L++ L+++D T L LA++
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEA-GAQLDVQDGVSCTPLQLALR 734
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/117 (31%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + E VV L Q N A+ +G L LA+ R L+ H A
Sbjct: 629 PLHLAARHGEEAVVSALL-----QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHA 683
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK 337
+V +K GW+ H +G+ L++ GA ++ G TPL L AL S K+
Sbjct: 684 NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD-GVSCTPLQL-ALRSRKQ 738
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 71.2 bits (173), Expect = 2e-12
Identities = 59/197 (29%), Positives = 86/197 (43%), Gaps = 34/197 (17%)
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATF-------------LIKNGAFVNAATLGAQETPL 327
D+D G + L + G++ + TF L+ GA A T+G ETPL
Sbjct: 1579 DLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPL 1638
Query: 328 HLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
HL A +S A LL+AGANPN D GRTPLH ++ A V LL
Sbjct: 1639 HLAARFSRPT-----------AARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLL 1687
Query: 388 QCKQLDLELKDHEGSTALWLAV---------QHITVSSDQSVNPFEDVPVVNGTSFDENS 438
+ +Q ++ + +G+T L LA + I +D ++ + N+
Sbjct: 1688 RSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNA 1747
Query: 439 FAAR-LIQRGSHTDAPD 454
AAR L+Q G+ DA D
Sbjct: 1748 RAARSLLQAGADKDAQD 1764
Score = 46.6 bits (109), Expect = 5e-05
Identities = 41/154 (26%), Positives = 67/154 (43%), Gaps = 16/154 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ + +V L L + + + + G L LA +E + L++ +A
Sbjct: 1670 PLHAAVAADAREVCQLLLRSRQTAVDARTED----GTTPLMLAARLAVEDLVEELIAAQA 1725
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
DV DK G + LH + AA L++ GA +A ++TPL L A +
Sbjct: 1726 DVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQD-NREQTPLFLAAREGA----- 1779
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
++A+ LL GA ++D G P V+
Sbjct: 1780 ------VEVAQLLLGLGAARELRDQAGLAPADVA 1807
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 70.5 bits (171), Expect = 3e-12
Identities = 58/190 (30%), Positives = 82/190 (43%), Gaps = 18/190 (9%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L L + S + A NG L +A + IATTL+ + A
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASP-----HAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
D + V + G + +H Q G + + L+ A VN + TPLHL A
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL-TPLHLAA--------- 705
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
+ +AE L+ GA+ + Q G TPLHV GN + + LLQ + K
Sbjct: 706 --QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKN 762
Query: 401 GSTALWLAVQ 410
G T L A Q
Sbjct: 763 GYTPLHQAAQ 772
Score = 62.4 bits (150), Expect = 9e-10
Identities = 56/191 (29%), Positives = 84/191 (43%), Gaps = 18/191 (9%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K R V+ L L S + +G + +A +I + L+ H A
Sbjct: 403 PLHIACKKNRIKVMELLLKHGAS-----IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ + G + LH + G +L+++GA V A Q TPLH+ A
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ-TPLHISARLGK----- 511
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
A I + LLQ GA+PN + G TPLH+S G+E V + LL L + +
Sbjct: 512 ------ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD-HGASLSITTKK 564
Query: 401 GSTALWLAVQH 411
G T L +A ++
Sbjct: 565 GFTPLHVAAKY 575
Score = 55.5 bits (132), Expect = 1e-07
Identities = 60/233 (25%), Positives = 101/233 (43%), Gaps = 23/233 (9%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG AL LA + + L+ +A+VD K G + LH G L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ NGA VNA + TPL++ A ++ + LL GA+ ++ G
Sbjct: 127 VTNGANVNAQSQNG-FTPLYMAA-----------QENHLEVVKFLLDNGASQSLATEDGF 174
Query: 369 TPLHVSIMAGNEYVFSQLLQ------CKQLDLELKDHEGST-ALWLAVQHITVSSDQSVN 421
TPL V++ G++ V S LL+ + L + + T A L +Q+ + +S +
Sbjct: 175 TPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKS 234
Query: 422 PFEDVPVVNGTSFDENSFAARLIQRGSHTD--APDTATGKARASRRGDAGVCR 472
F P+ + + A L+ R + D A + T AS+RG+A + +
Sbjct: 235 GF--TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVK 285
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 21/171 (12%)
Query: 219 EYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRL--ESIATTLV 276
E LH A + + +VV YL++ +Q+ K D L +S RL I L+
Sbjct: 467 ETALHMAARSGQAEVV-RYLVQDGAQVEAKAK------DDQTPLHISARLGKADIVQQLL 519
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
A + SG++ LH + G A FL+ +GA ++ T TPLH+ A Y
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGF-TPLHVAAKYGK- 577
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++A LLQ A+P+ G TPLHV+ N+ V LL
Sbjct: 578 ----------LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Score = 53.1 bits (126), Expect = 5e-07
Identities = 45/143 (31%), Positives = 67/143 (46%), Gaps = 15/143 (10%)
Query: 239 IEMDSQLPGK---LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHK 295
++M S L G+ +N ++ +G L LA ++A LV+ A VD K G++ LH
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736
Query: 296 GIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQ 355
G G++ FL+++ A VNA T TPLH A + H+ I LLQ
Sbjct: 737 GCHYGNIKIVNFLLQHSAKVNAKTKNGY-TPLHQAA---QQGHT--------HIINVLLQ 784
Query: 356 AGANPNMQDSKGRTPLHVSIMAG 378
A+PN G T L ++ G
Sbjct: 785 NNASPNELTVNGNTALGIARRLG 807
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/162 (30%), Positives = 70/162 (43%), Gaps = 13/162 (8%)
Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI 309
N + G+ AL +A + LV A V+ K + LH + G L+
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 310 KNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369
+ GA NAAT TPLHL S+++ DV A LL GA+ ++ KG T
Sbjct: 520 QQGASPNAATTSGY-TPLHL----SAREGHEDV-------AAFLLDHGASLSITTKKGFT 567
Query: 370 PLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
PLHV+ G V + LLQ K + G T L +A +
Sbjct: 568 PLHVAAKYGKLEVANLLLQ-KSASPDAAGKSGLTPLHVAAHY 608
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/191 (25%), Positives = 86/191 (45%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I SKT+ PLH A + + + V L L Q +++ ++ AL +A
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLL-----QHNVPVDDVTNDYLTALHVAAHCGHYK 381
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ KA+ + +G++ LH ++ + L+K+GA + A T TP+H+
Sbjct: 382 VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL-TPIHVA 440
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ-C 389
A I L+ GA+PN + +G T LH++ +G V L+Q
Sbjct: 441 AFMGH-----------VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 390 KQLDLELKDHE 400
Q++ + KD +
Sbjct: 490 AQVEAKAKDDQ 500
Score = 46.2 bits (108), Expect = 7e-05
Identities = 43/186 (23%), Positives = 83/186 (44%), Gaps = 19/186 (10%)
Query: 272 ATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVA 331
A + + D+++ +++G + LH + G + + L++ A V+AAT T LH+ +
Sbjct: 57 ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG-NTALHIAS 115
Query: 332 LYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQ 391
L + A++ + L+ GAN N Q G TPL+++ + V LL
Sbjct: 116 L-----------AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD-NG 163
Query: 392 LDLELKDHEGSTALWLAVQH-----ITVSSDQSVNPFEDVPVVN-GTSFDENSFAARLIQ 445
L +G T L +A+Q +++ + +P ++ D+ AA L+Q
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 446 RGSHTD 451
++ D
Sbjct: 224 NDNNAD 229
Score = 45.8 bits (107), Expect = 9e-05
Identities = 47/183 (25%), Positives = 76/183 (41%), Gaps = 22/183 (12%)
Query: 222 LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
LH A K +VV L Q ++ A G+ AL +A + LV++ A+
Sbjct: 78 LHLASKEGHVEVVSELL-----QREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 282 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT--------LGAQETPLHLVALY 333
V+ ++G++ L+ Q L FL+ NGA + AT + Q+ +V+L
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 334 SSKKHSADV---------MSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFS 384
V + + A LLQ N +++ G TPLH++ GN V +
Sbjct: 193 LENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT 252
Query: 385 QLL 387
LL
Sbjct: 253 LLL 255
Score = 41.6 bits (96), Expect = 0.002
Identities = 50/193 (25%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 242 DSQLPGKLNEADHNGDLA-------LDLALSRRLESIATTLVSHKADVDMVDKSGWSLLH 294
D++ L + D+N D+ L +A ++AT L++ A VD ++ + LH
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 295 KGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALL 354
+RG+ L+ GA ++A T TPLH A S Q+ E LL
Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTRDGL-TPLHCGA-----------RSGHEQVVEMLL 321
Query: 355 QAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HI 412
A + G +PLH++ G+ QLL + ++ ++ TAL +A H
Sbjct: 322 DRAAPILSKTKNGLSPLHMATQ-GDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHY 380
Query: 413 TVSS---DQSVNP 422
V+ D+ NP
Sbjct: 381 KVAKVLLDKKANP 393
Score = 40.8 bits (94), Expect = 0.003
Identities = 44/168 (26%), Positives = 64/168 (38%), Gaps = 17/168 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K ++V L L K++ +G L E + L+ A
Sbjct: 271 PLHVASKRGNANMVKLLL-----DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G S LH Q L L+++ V+ T T LH+ A K
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYK--- 381
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
+A+ LL ANPN + G TPLH++ V LL+
Sbjct: 382 --------VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK 421
>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
sapiens]
Length = 621
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/180 (26%), Positives = 86/180 (47%), Gaps = 13/180 (7%)
Query: 60 DLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWS---LANLSSTKELDLSDANPEVTMT 116
D+ + ++ D ++ G+R H+ VLAA S + LA EL L + +P+V
Sbjct: 25 DMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQ 84
Query: 117 MLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEE 176
+L ++YT E+ D+ + +L A+RFQ+ + C + + + NC+ ++
Sbjct: 85 VLHYLYTSEIAL--DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLL 142
Query: 177 LNASTLMNYCAEIIASHWDDL-RKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVF 235
L+ + L + I +H+ + R DF +SA L +I S + VE+E+ VF
Sbjct: 143 LDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISS-------DGLNVEKEEAVF 195
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 65.9 bits (159), Expect = 8e-11
Identities = 52/212 (24%), Positives = 103/212 (48%), Gaps = 21/212 (9%)
Query: 29 ETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAA 88
+TEK+ A A +E+ ++ + ++ ++ +Q+ D+ + V +R I AH+ VLAA
Sbjct: 13 KTEKKLA-----AREEAK---LLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAA 64
Query: 89 RSDSWSL---ANLSSTK--ELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLAN 143
S ++L N+ +K E++L DA P++ ++ + YT + ++V L+ AN
Sbjct: 65 ASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNV--QSLLDAAN 122
Query: 144 RFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFS 203
++Q++ +++ C + V+ NC+ AE L+ L + I H+ ++ K D
Sbjct: 123 QYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD-- 180
Query: 204 SMSAQLLYKMIKSKTEYPLHKAIKVEREDVVF 235
+ L +K T + V ED V+
Sbjct: 181 ----EFLQLDVKRVTHLLNQDTLTVRAEDQVY 208
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 65.9 bits (159), Expect = 8e-11
Identities = 72/274 (26%), Positives = 110/274 (40%), Gaps = 40/274 (14%)
Query: 162 VNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYP 221
VN R+ + +QT + A+ CAE +A L D S SA
Sbjct: 100 VNARD--KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA-------------- 143
Query: 222 LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
LH A+ + V L L + S LN D L A + LV+ AD
Sbjct: 144 LHHAVHSGHLETVNLLLNKGAS-----LNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
Query: 282 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 341
+ D+ G+ LLH G + +L++ GA ++ T LH +A Y +
Sbjct: 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN-TALH-IACYLGQD---- 252
Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
+A L+ AGAN N + KG TPLHV+ ++ N + +LL D+ + EG
Sbjct: 253 ------AVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306
Query: 402 STALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
+ L +A H + Q + + NG+ D
Sbjct: 307 KSPLHMAAIHGRFTRSQ-------ILIQNGSEID 333
Score = 55.5 bits (132), Expect = 1e-07
Identities = 46/167 (27%), Positives = 81/167 (48%), Gaps = 18/167 (10%)
Query: 222 LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
LH A + +VV YL+ M +++ +E + G+ AL +A +++A LV+ A+
Sbjct: 210 LHTAAASGQIEVV-KYLLRMGAEI----DEPNAFGNTALHIACYLGQDAVAIELVNAGAN 264
Query: 282 VDMVDKSGWSLLH-KGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
V+ + G++ LH + L+ NGA VN + + +PLH+ A++ S
Sbjct: 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGK-SPLHMAAIHGRFTRS- 322
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
+ L+Q G+ + D G TPLHV+ G+E + S L+
Sbjct: 323 ----------QILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Score = 50.4 bits (119), Expect = 4e-06
Identities = 54/213 (25%), Positives = 82/213 (38%), Gaps = 52/213 (24%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N D+ G L A S L+S AD+ DK G + LH G A L
Sbjct: 416 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
Query: 309 IKNGAFVNAATLGAQETPLHLVAL---------YSSKKHSADVMSEMAQ--------IAE 351
+ GA VN A +PLH A ++ H A+ + + E
Sbjct: 476 VTAGAGVNEADCKGC-SPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLE 534
Query: 352 ALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ----------------------- 388
LL GA+P+++D +G T +H + GN LL+
Sbjct: 535 FLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594
Query: 389 ---CKQL--------DLELKDHEGSTALWLAVQ 410
C+ L +L+++DH+G TAL+LA +
Sbjct: 595 NGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627
Score = 49.3 bits (116), Expect = 8e-06
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 11/168 (6%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N G L +A + + L+ + +++D DK G + LH + G + L
Sbjct: 299 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Query: 309 IKNGAFVNAATLGAQET-PLHLVALYSSKK------HSADVMSEMAQIA-EALLQAGANP 360
+ NGA + A G + PLHL L+ S + S ++ ++ E +L AG +
Sbjct: 359 MTNGA--DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
Query: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
N D+ GRT LH + GN + LL DL +D G T L A
Sbjct: 417 NTPDNLGRTCLHAAASGGNVECLNLLLS-SGADLRRRDKFGRTPLHYA 463
Score = 49.3 bits (116), Expect = 8e-06
Identities = 50/165 (30%), Positives = 70/165 (42%), Gaps = 20/165 (12%)
Query: 253 DHNGDLALDLALSRRLESIATTLVSHKADVDM----VDKSGWSLLHKGIQRGDLFAATFL 308
D G + LA + ++ TL+ D VD SG+S +H G L
Sbjct: 751 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQA-GAN-PNMQDSK 366
+++ F + G TPLH V++ E LL A GA N +D+K
Sbjct: 811 LEHSPF--SYLEGNPFTPLHCA-----------VINNQDSTTEMLLGALGAKIVNSRDAK 857
Query: 367 GRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
GRTPLH + A N LLQ Q ++ DH G TAL A ++
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQ-HQAEVNATDHTGRTALMTAAEN 901
Score = 46.6 bits (109), Expect = 5e-05
Identities = 55/199 (27%), Positives = 80/199 (40%), Gaps = 18/199 (9%)
Query: 203 SSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDL 262
S +S + ++ + PLH A V DV L L+ M +N D L
Sbjct: 26 SLLSQKENINVLDQERRTPLHAAAYVG--DVPILQLLLMSG---ANVNAKDTLWLTPLHR 80
Query: 263 ALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGA 322
A + R E + L++H ADV+ DK + LH A L + +N A
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
Query: 323 QETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV 382
+ H V HS + + LL GA+ N+ D K R PLH + G+ V
Sbjct: 141 RSALHHAV-------HSGHL-----ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188
Query: 383 FSQLLQCKQLDLELKDHEG 401
+LL + DL KD +G
Sbjct: 189 L-KLLVARGADLGCKDRKG 206
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 26/146 (17%)
Query: 265 SRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA-TLGAQ 323
SR +E + + L+S K +++++D+ + LH GD+ L+ +GA VNA TL
Sbjct: 18 SRDVEEVRS-LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL- 75
Query: 324 ETPLHLVALYSSKK-------HSADV---------------MSEMAQIAEALLQAGANPN 361
TPLH A ++K HSADV + + AEAL ++ N
Sbjct: 76 -TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN 134
Query: 362 MQDSKGRTPLHVSIMAGNEYVFSQLL 387
+ D GR+ LH ++ +G+ + LL
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLL 160
Score = 42.7 bits (99), Expect = 7e-04
Identities = 46/165 (27%), Positives = 63/165 (38%), Gaps = 25/165 (15%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVD-KSGWSLLHKGIQRGDLFAATF 307
L+ DH G AL LA R L +H A + + K W+ LH G +
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
Query: 308 LIKNG--AFVNAATLGAQETPL------------HLVALYSSKKHSADVMSEMA------ 347
LI +G A + +TPL HL+ S +AD+ A
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
Query: 348 ----QIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
ALL A +D KGRTP+H++ G+ V LLQ
Sbjct: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/159 (25%), Positives = 69/159 (43%), Gaps = 21/159 (13%)
Query: 216 SKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSR-RLESIATT 274
+K PLH A + + + L Q ++N DH G AL A + ++
Sbjct: 856 AKGRTPLHAAAFADNVSGLRMLL-----QHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910
Query: 275 LVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI---KNGAFVNAATLGAQETPLHLVA 331
L KAD+ ++D++ + LH +G A ++ ++ +NA T A + PLH+ A
Sbjct: 911 LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINA-TNSALQMPLHIAA 969
Query: 332 LYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTP 370
+ +A + +ALL GA D +G TP
Sbjct: 970 -----------RNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 40.8 bits (94), Expect = 0.003
Identities = 46/183 (25%), Positives = 72/183 (39%), Gaps = 12/183 (6%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ ++ + L + +++ +N D G L A S L+ H+A
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKI---VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQA 882
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+V+ D +G + L + G A FL+ G + T LHL SK H
Sbjct: 883 EVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLAC---SKGHEK 939
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
+ +A+ + L N +Q PLH++ G V LL L + D E
Sbjct: 940 CALMILAETQDLGLINATNSALQ-----MPLHIAARNGLASVVQALLSHGATVLAV-DEE 993
Query: 401 GST 403
G T
Sbjct: 994 GHT 996
Score = 38.9 bits (89), Expect = 0.011
Identities = 47/177 (26%), Positives = 76/177 (42%), Gaps = 25/177 (14%)
Query: 232 DVVFLYLIEMDSQLP-GKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGW 290
++ F L +++S +P L+ A +NG L+++A TLV+ +D+ D G
Sbjct: 571 EMSFNCLEDVESTIPVSPLHLAAYNGHC-------EALKTLAETLVN----LDVRDHKGR 619
Query: 291 SLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVAL--YSSKKHSADVMSEMAQ 348
+ L +RG L +GA + TPLH A ++ H E A
Sbjct: 620 TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERAD 679
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
I + + D+ G+TPL ++IM G+ LL+ K + D G TAL
Sbjct: 680 ITDVM----------DAYGQTPLMLAIMNGHVDCVHLLLE-KGSTADAADLRGRTAL 725
Score = 37.0 bits (84), Expect = 0.040
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 12/100 (12%)
Query: 323 QETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV 382
+ TPLH A + DV I + LL +GAN N +D+ TPLH + + NE V
Sbjct: 41 RRTPLHAAA------YVGDV-----PILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV 89
Query: 383 FSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNP 422
LL D+ +D T L +A + +++ P
Sbjct: 90 LG-LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Score = 31.6 bits (70), Expect = 1.7
Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 6/75 (8%)
Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
+ S + +LL N N+ D + RTPLH + G+ + QLL ++ KD
Sbjct: 16 IFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAKD--- 71
Query: 402 STALWLAVQHITVSS 416
LWL H +S
Sbjct: 72 --TLWLTPLHRAAAS 84
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/103 (40%), Positives = 56/103 (54%), Gaps = 11/103 (10%)
Query: 308 LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
LI GA + A T ET LHL A Y+ A A+ LL AGA+ N QD G
Sbjct: 1824 LICQGAQLGARTDRTGETALHLAARYAR-----------ADAAKRLLDAGADTNAQDHSG 1872
Query: 368 RTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ 410
RTPLH ++ A + VF L++ + DL+ + +GSTAL LA +
Sbjct: 1873 RTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAAR 1915
Score = 50.4 bits (119), Expect = 4e-06
Identities = 44/154 (28%), Positives = 68/154 (44%), Gaps = 16/154 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ + + V + + + L ++ + G AL LA +E + L++ A
Sbjct: 1875 PLHTAVTADAQGVFQILIRNRSTDLDARMAD----GSTALILAARLAVEGMVEELIASHA 1930
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
DV+ VD+ G S LH ++ A L+KNGA + +ETPL L A S
Sbjct: 1931 DVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQD-SKEETPLFLAAREGS----- 1984
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
+ A+ LL AN + D R P V+
Sbjct: 1985 ------YEAAKLLLDHFANREITDHLDRLPRDVA 2012
Score = 46.6 bits (109), Expect = 5e-05
Identities = 48/170 (28%), Positives = 72/170 (42%), Gaps = 25/170 (14%)
Query: 253 DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNG 312
D G+ AL LA A L+ AD + D SG + LH + LI+N
Sbjct: 1836 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR 1895
Query: 313 -------------AFVNAATLGAQETPLHLVALYS----------SKKHSADVMSEMAQI 349
A + AA L + L+A ++ S H A ++ + +
Sbjct: 1896 STDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNV-EA 1954
Query: 350 AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
ALL+ GAN +MQDSK TPL ++ G+ Y ++LL + E+ DH
Sbjct: 1955 TLALLKNGANKDMQDSKEETPLFLAAREGS-YEAAKLLLDHFANREITDH 2003
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 63.5 bits (153), Expect = 4e-10
Identities = 41/176 (23%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 47 SESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELD- 105
SE ++L+++ + EQ + D KI + D I H+ VLAA SD + + KE D
Sbjct: 31 SEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDD 90
Query: 106 ----LSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSL 161
+++ + + L + YT + + +D+V + +L++ Q+ L + C ++
Sbjct: 91 GSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEM--FFQLSSFLQVSFLSKACSDFLIKS 148
Query: 162 VNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDL-RKEDFSSMSAQLLYKMIKS 216
+N+ NC++ ++ +++L ++ + H+ L + DF M+ +L K ++S
Sbjct: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLES 204
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 63.5 bits (153), Expect = 4e-10
Identities = 41/176 (23%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 47 SESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELD- 105
SE ++L+++ + EQ + D KI + D I H+ VLAA SD + + KE D
Sbjct: 31 SEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDD 90
Query: 106 ----LSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSL 161
+++ + + L + YT + + +D+V + +L++ Q+ L + C ++
Sbjct: 91 GSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEM--FFQLSSFLQVSFLSKACSDFLIKS 148
Query: 162 VNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDL-RKEDFSSMSAQLLYKMIKS 216
+N+ NC++ ++ +++L ++ + H+ L + DF M+ +L K ++S
Sbjct: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLES 204
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 63.2 bits (152), Expect = 5e-10
Identities = 42/125 (33%), Positives = 65/125 (52%), Gaps = 18/125 (14%)
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
I GA ++ T ET LHL A YS + A+ LL+A A+ N+QD+ GR
Sbjct: 1914 IYQGASLHNQTDRTGETALHLAARYSR-----------SDAAKRLLEASADANIQDNMGR 1962
Query: 369 TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ-------HITVSSDQSVN 421
TPLH ++ A + VF L++ + DL+ + H+G+T L LA + ++S VN
Sbjct: 1963 TPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVN 2022
Query: 422 PFEDV 426
+D+
Sbjct: 2023 AVDDL 2027
Score = 53.5 bits (127), Expect = 4e-07
Identities = 44/154 (28%), Positives = 69/154 (44%), Gaps = 16/154 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ + + V + + + L ++ H+G L LA +E + L++ A
Sbjct: 1964 PLHAAVSADAQGVFQILIRNRATDLDARM----HDGTTPLILAARLAVEGMLEDLINSHA 2019
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
DV+ VD G S LH ++ AA L+KNGA + +ETPL L A S
Sbjct: 2020 DVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQN-NREETPLFLAAREGS----- 2073
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
+ A+ LL AN ++ D R P ++
Sbjct: 2074 ------YETAKVLLDHFANRDITDHMDRLPRDIA 2101
Score = 47.4 bits (111), Expect = 3e-05
Identities = 43/172 (25%), Positives = 72/172 (41%), Gaps = 23/172 (13%)
Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI 309
N+ D G+ AL LA A L+ AD ++ D G + LH + LI
Sbjct: 1922 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILI 1981
Query: 310 KNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQI-------------------- 349
+N A A + TPL L A + + D+++ A +
Sbjct: 1982 RNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNV 2041
Query: 350 --AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
A LL+ GAN +MQ+++ TPL ++ G+ Y +++L + ++ DH
Sbjct: 2042 DAAVVLLKNGANKDMQNNREETPLFLAAREGS-YETAKVLLDHFANRDITDH 2092
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 63.2 bits (152), Expect = 5e-10
Identities = 52/191 (27%), Positives = 85/191 (44%), Gaps = 30/191 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L L + S + NG L +A + IA+TL+++ A
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT--------LGAQETPLHLVAL 332
+ ++V K G + LH Q G T L+ GA ++ +T L AQE +++ +
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
Query: 333 YSSKKHSADVMSEM---------------AQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
+ KH AD + ++ LL+ GAN N + G TPLH +
Sbjct: 693 LT--KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 750
Query: 378 GNEYVFSQLLQ 388
G+ ++ + LLQ
Sbjct: 751 GHTHIINVLLQ 761
Score = 56.6 bits (135), Expect = 5e-08
Identities = 63/228 (27%), Positives = 89/228 (39%), Gaps = 43/228 (18%)
Query: 155 EKGVMSLVNVRNCIRFYQTAEELN----ASTLMNYCAEIIASHWDDLRKEDFSSMSAQLL 210
EKG +N A + N ASTL+NY AE
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET--------------------- 634
Query: 211 YKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
++ + PLH A + D+V L L + ++ + +G +L LA +
Sbjct: 635 -NIVTKQGVTPLHLASQEGHTDMVTLLLDK-----GANIHMSTKSGLTSLHLAAQEDKVN 688
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L H AD D K G++ L G++ FL+K GA VNA T TPLH
Sbjct: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQA 747
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
A + H+ I LLQ GA PN + G T L ++ G
Sbjct: 748 A---QQGHT--------HIINVLLQHGAKPNATTANGNTALAIAKRLG 784
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/239 (26%), Positives = 100/239 (41%), Gaps = 27/239 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG AL LA + L+ + VD K G + LH G L
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+K GA +NA + TPL++ A +++ DV+ + LL+ GAN + G
Sbjct: 96 VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 143
Query: 369 TPLHVSIMAGNEYVFSQLLQ------CKQLDLEL---KDHEGSTALWLAVQH-ITVSSDQ 418
TPL V++ G+ + LL+ + L + KD S AL L H V S
Sbjct: 144 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 203
Query: 419 SVNPFED---VPVVNGTSFDENSFAARLIQRGSHTD--APDTATGKARASRRGDAGVCR 472
VN + P+ + + A L+ RG+ D A + T AS+RG+ + +
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Score = 52.0 bits (123), Expect = 1e-06
Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 29/213 (13%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K R + ++E+ + + +G + +A +I L+ + A
Sbjct: 380 PLHIACKKNR-----IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
D+ + G + LH + G + L++NGA V+A ++TPLH+ + +
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQ 493
Query: 341 DVMSEMAQ----------------------IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
++ MA +A LL+AGA ++ KG TPLHV+ G
Sbjct: 494 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 553
Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
+ V LLQ ++ + G T L +A +
Sbjct: 554 SLDVAKLLLQ-RRAAADSAGKNGLTPLHVAAHY 585
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 27/164 (16%)
Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
D++ L + DHN D+ + ++R ES +AT L++ A VD
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242
Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
++G + LH +RG+ L+ G ++A T TPLH A S
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 290
Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
Q+ E LL+ GA + G +PLH++ + LLQ K
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 24/179 (13%)
Query: 255 NGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
NG L +A + + LV + A + + +SG + +H G L L++NGA
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435
Query: 315 VNAATLGAQETPLHLV----------------ALYSSKKHSADVMSEMA------QIAEA 352
+ + ET LH+ AL ++ +A +I +
Sbjct: 436 PDVTNIRG-ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 353 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
LLQ A+P+ + G TPLH+S G V S LL+ L +G T L +A ++
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKY 552
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/118 (31%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
I L+ H A D +G++ LH + G + A+ L++ GA + AT TPLH+
Sbjct: 491 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TPLHVA 549
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
A Y S +A+ LLQ A + G TPLHV+ N+ V LL+
Sbjct: 550 AKYGS-----------LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 17/170 (10%)
Query: 205 MSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLAL 264
+ A + + K PLH A K DV L L Q + A NG L +A
Sbjct: 529 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAADSAGKNGLTPLHVAA 583
Query: 265 SRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE 324
+ +A L+ A K+G++ LH ++ + A+ L+ GA N T
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG-V 642
Query: 325 TPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
TPLHL +S++ D+++ LL GAN +M G T LH++
Sbjct: 643 TPLHL----ASQEGHTDMVT-------LLLDKGANIHMSTKSGLTSLHLA 681
Score = 37.7 bits (86), Expect = 0.024
Identities = 41/154 (26%), Positives = 64/154 (41%), Gaps = 17/154 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K ++V L L G+++ +G L A + + L+ A
Sbjct: 248 PLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 302
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G S LH Q + L+++ A V+ TL T LH+ A H
Sbjct: 303 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL-TALHVAA------HCG 355
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
++ + LL ANPN + G TPLH++
Sbjct: 356 HY-----RVTKLLLDKRANPNARALNGFTPLHIA 384
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 63.2 bits (152), Expect = 5e-10
Identities = 52/191 (27%), Positives = 85/191 (44%), Gaps = 30/191 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L L + S + NG L +A + IA+TL+++ A
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT--------LGAQETPLHLVAL 332
+ ++V K G + LH Q G T L+ GA ++ +T L AQE +++ +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 333 YSSKKHSADVMSEM---------------AQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
+ KH AD + ++ LL+ GAN N + G TPLH +
Sbjct: 714 LT--KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771
Query: 378 GNEYVFSQLLQ 388
G+ ++ + LLQ
Sbjct: 772 GHTHIINVLLQ 782
Score = 56.6 bits (135), Expect = 5e-08
Identities = 63/228 (27%), Positives = 89/228 (39%), Gaps = 43/228 (18%)
Query: 155 EKGVMSLVNVRNCIRFYQTAEELN----ASTLMNYCAEIIASHWDDLRKEDFSSMSAQLL 210
EKG +N A + N ASTL+NY AE
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET--------------------- 655
Query: 211 YKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
++ + PLH A + D+V L L + ++ + +G +L LA +
Sbjct: 656 -NIVTKQGVTPLHLASQEGHTDMVTLLLDK-----GANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L H AD D K G++ L G++ FL+K GA VNA T TPLH
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQA 768
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
A + H+ I LLQ GA PN + G T L ++ G
Sbjct: 769 A---QQGHT--------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/239 (26%), Positives = 100/239 (41%), Gaps = 27/239 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG AL LA + L+ + VD K G + LH G L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+K GA +NA + TPL++ A +++ DV+ + LL+ GAN + G
Sbjct: 117 VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 164
Query: 369 TPLHVSIMAGNEYVFSQLLQ------CKQLDLEL---KDHEGSTALWLAVQH-ITVSSDQ 418
TPL V++ G+ + LL+ + L + KD S AL L H V S
Sbjct: 165 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 419 SVNPFED---VPVVNGTSFDENSFAARLIQRGSHTD--APDTATGKARASRRGDAGVCR 472
VN + P+ + + A L+ RG+ D A + T AS+RG+ + +
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Score = 52.0 bits (123), Expect = 1e-06
Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 29/213 (13%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K R + ++E+ + + +G + +A +I L+ + A
Sbjct: 401 PLHIACKKNR-----IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
D+ + G + LH + G + L++NGA V+A ++TPLH+ + +
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQ 514
Query: 341 DVMSEMAQ----------------------IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
++ MA +A LL+AGA ++ KG TPLHV+ G
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
+ V LLQ ++ + G T L +A +
Sbjct: 575 SLDVAKLLLQ-RRAAADSAGKNGLTPLHVAAHY 606
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 27/164 (16%)
Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
D++ L + DHN D+ + ++R ES +AT L++ A VD
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
++G + LH +RG+ L+ G ++A T TPLH A S
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 311
Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
Q+ E LL+ GA + G +PLH++ + LLQ K
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 24/179 (13%)
Query: 255 NGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
NG L +A + + LV + A + + +SG + +H G L L++NGA
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 315 VNAATLGAQETPLHLV----------------ALYSSKKHSADVMSEMA------QIAEA 352
+ + ET LH+ AL ++ +A +I +
Sbjct: 457 PDVTNIRG-ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 353 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
LLQ A+P+ + G TPLH+S G V S LL+ L +G T L +A ++
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKY 573
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/118 (31%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
I L+ H A D +G++ LH + G + A+ L++ GA + AT TPLH+
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TPLHVA 570
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
A Y S +A+ LLQ A + G TPLHV+ N+ V LL+
Sbjct: 571 AKYGS-----------LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 17/170 (10%)
Query: 205 MSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLAL 264
+ A + + K PLH A K DV L L Q + A NG L +A
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAADSAGKNGLTPLHVAA 604
Query: 265 SRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE 324
+ +A L+ A K+G++ LH ++ + A+ L+ GA N T
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG-V 663
Query: 325 TPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
TPLHL +S++ D+++ LL GAN +M G T LH++
Sbjct: 664 TPLHL----ASQEGHTDMVT-------LLLDKGANIHMSTKSGLTSLHLA 702
Score = 37.7 bits (86), Expect = 0.024
Identities = 41/154 (26%), Positives = 64/154 (41%), Gaps = 17/154 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K ++V L L G+++ +G L A + + L+ A
Sbjct: 269 PLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G S LH Q + L+++ A V+ TL T LH+ A H
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL-TALHVAA------HCG 376
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
++ + LL ANPN + G TPLH++
Sbjct: 377 HY-----RVTKLLLDKRANPNARALNGFTPLHIA 405
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 63.2 bits (152), Expect = 5e-10
Identities = 52/191 (27%), Positives = 85/191 (44%), Gaps = 30/191 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L L + S + NG L +A + IA+TL+++ A
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASP-----HATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAAT--------LGAQETPLHLVAL 332
+ ++V K G + LH Q G T L+ GA ++ +T L AQE +++ +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 333 YSSKKHSADVMSEM---------------AQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
+ KH AD + ++ LL+ GAN N + G TPLH +
Sbjct: 714 LT--KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQ 771
Query: 378 GNEYVFSQLLQ 388
G+ ++ + LLQ
Sbjct: 772 GHTHIINVLLQ 782
Score = 56.6 bits (135), Expect = 5e-08
Identities = 63/228 (27%), Positives = 89/228 (39%), Gaps = 43/228 (18%)
Query: 155 EKGVMSLVNVRNCIRFYQTAEELN----ASTLMNYCAEIIASHWDDLRKEDFSSMSAQLL 210
EKG +N A + N ASTL+NY AE
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET--------------------- 655
Query: 211 YKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
++ + PLH A + D+V L L + ++ + +G +L LA +
Sbjct: 656 -NIVTKQGVTPLHLASQEGHTDMVTLLLDK-----GANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L H AD D K G++ L G++ FL+K GA VNA T TPLH
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGY-TPLHQA 768
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
A + H+ I LLQ GA PN + G T L ++ G
Sbjct: 769 A---QQGHT--------HIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/239 (26%), Positives = 100/239 (41%), Gaps = 27/239 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG AL LA + L+ + VD K G + LH G L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+K GA +NA + TPL++ A +++ DV+ + LL+ GAN + G
Sbjct: 117 VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 164
Query: 369 TPLHVSIMAGNEYVFSQLLQ------CKQLDLEL---KDHEGSTALWLAVQH-ITVSSDQ 418
TPL V++ G+ + LL+ + L + KD S AL L H V S
Sbjct: 165 TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224
Query: 419 SVNPFED---VPVVNGTSFDENSFAARLIQRGSHTD--APDTATGKARASRRGDAGVCR 472
VN + P+ + + A L+ RG+ D A + T AS+RG+ + +
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Score = 52.0 bits (123), Expect = 1e-06
Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 29/213 (13%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K R + ++E+ + + +G + +A +I L+ + A
Sbjct: 401 PLHIACKKNR-----IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
D+ + G + LH + G + L++NGA V+A ++TPLH+ + +
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQ 514
Query: 341 DVMSEMAQ----------------------IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
++ MA +A LL+AGA ++ KG TPLHV+ G
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
+ V LLQ ++ + G T L +A +
Sbjct: 575 SLDVAKLLLQ-RRAAADSAGKNGLTPLHVAAHY 606
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/164 (26%), Positives = 69/164 (42%), Gaps = 27/164 (16%)
Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
D++ L + DHN D+ + ++R ES +AT L++ A VD
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
++G + LH +RG+ L+ G ++A T TPLH A S
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 311
Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
Q+ E LL+ GA + G +PLH++ + LLQ K
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 24/179 (13%)
Query: 255 NGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
NG L +A + + LV + A + + +SG + +H G L L++NGA
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 315 VNAATLGAQETPLHLV----------------ALYSSKKHSADVMSEMA------QIAEA 352
+ + ET LH+ AL ++ +A +I +
Sbjct: 457 PDVTNIRG-ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 353 LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
LLQ A+P+ + G TPLH+S G V S LL+ L +G T L +A ++
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTPLHVAAKY 573
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/118 (31%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
I L+ H A D +G++ LH + G + A+ L++ GA + AT TPLH+
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGF-TPLHVA 570
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
A Y S +A+ LLQ A + G TPLHV+ N+ V LL+
Sbjct: 571 AKYGS-----------LDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 17/170 (10%)
Query: 205 MSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLAL 264
+ A + + K PLH A K DV L L Q + A NG L +A
Sbjct: 550 LEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL-----QRRAAADSAGKNGLTPLHVAA 604
Query: 265 SRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQE 324
+ +A L+ A K+G++ LH ++ + A+ L+ GA N T
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQG-V 663
Query: 325 TPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
TPLHL +S++ D+++ LL GAN +M G T LH++
Sbjct: 664 TPLHL----ASQEGHTDMVT-------LLLDKGANIHMSTKSGLTSLHLA 702
Score = 37.7 bits (86), Expect = 0.024
Identities = 41/154 (26%), Positives = 64/154 (41%), Gaps = 17/154 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K ++V L L G+++ +G L A + + L+ A
Sbjct: 269 PLHVASKRGNTNMVKLLL-----DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G S LH Q + L+++ A V+ TL T LH+ A H
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYL-TALHVAA------HCG 376
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
++ + LL ANPN + G TPLH++
Sbjct: 377 HY-----RVTKLLLDKRANPNARALNGFTPLHIA 405
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 63.2 bits (152), Expect = 5e-10
Identities = 60/257 (23%), Positives = 105/257 (40%), Gaps = 29/257 (11%)
Query: 222 LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
LH A++ +E+ L+ + N ++ G L +A+ RR+ + L++ K
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANP-----NLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
Query: 282 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 341
V+ D+ W+ LH Q GD + L++ A VN + TP+H+ + +
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR-TPMHVACQHGQE----- 550
Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
I LL+ G + ++Q PLH + G+ + L + + + + +G
Sbjct: 551 ------NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDG 604
Query: 402 STALWLAVQH---------ITVSSDQSV-NPFEDVPVVNGTSFDENSFAARLIQRGSHTD 451
T L LA Q I + SD +V + P+ S A L+ RG+ +
Sbjct: 605 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664
Query: 452 A--PDTATGKARASRRG 466
A D T A+R G
Sbjct: 665 AMTSDGYTALHLAARNG 681
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/153 (28%), Positives = 68/153 (44%), Gaps = 28/153 (18%)
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHL---------VA 331
DVD+ SG SLLH ++ G A +L+ N A N + TPLH+ V
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG-STPLHMAVERRVRGVVE 488
Query: 332 LYSSKKHSADVMSEMAQIA-------------EALLQAGANPNMQDSKGRTPLHVSIMAG 378
L ++K S + E A LL+ A+ N D +GRTP+HV+ G
Sbjct: 489 LLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
E + LL+ + +D+ L+ + WL + +
Sbjct: 549 QENIVRILLR-RGVDVSLQGKDA----WLPLHY 576
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 22/118 (18%)
Query: 270 SIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHL 329
S A L+ A + + G++ LH + G L L++ A V A +T LHL
Sbjct: 651 STARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG-PLNQTALHL 709
Query: 330 VALYSSKKH-----SADVMS----------------EMAQIAEALLQAGANPNMQDSK 366
A + + SADV+ AQ E LL+ GA+ N+Q K
Sbjct: 710 AAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
Score = 30.0 bits (66), Expect = 4.9
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 259 ALDLALSRRLESIATTLVSHKADV-DMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
AL LA + + LVS ADV D+ D+ G S LH Q L+++GA +N
Sbjct: 706 ALHLAAAHGHSEVVEELVS--ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Query: 318 ATLGAQ 323
+L Q
Sbjct: 764 QSLKFQ 769
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 61.6 bits (148), Expect = 2e-09
Identities = 65/212 (30%), Positives = 94/212 (44%), Gaps = 40/212 (18%)
Query: 219 EYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSH 278
E P K +K E E + L E D + + H L+ A RR S+A T
Sbjct: 1762 EGPQPKKVKAEDEAL----LSEEDDPIDRRPWTQQH-----LEAADIRRTPSLALTPPQA 1812
Query: 279 KADVDMVDKS-----GWSLLHKGIQRG---DLF------------AATFLIKNGAFVNAA 318
+ +VD++D + G + L RG DL T L+ GA + A
Sbjct: 1813 EQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQ 1872
Query: 319 TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
T E LHL A YS A A+ LL AGA+ N QD+ GR PLH ++ A
Sbjct: 1873 TDRTGEMALHLAARYSR-----------ADAAKRLLDAGADANAQDNMGRCPLHAAVAAD 1921
Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ 410
+ VF L++ + DL+ + ++G+T L LA +
Sbjct: 1922 AQGVFQILIRNRVTDLDARMNDGTTPLILAAR 1953
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/154 (28%), Positives = 69/154 (44%), Gaps = 16/154 (10%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ + + V + + + L ++N+ G L LA +E + L++ +A
Sbjct: 1913 PLHAAVAADAQGVFQILIRNRVTDLDARMND----GTTPLILAARLAVEGMVAELINCQA 1968
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
DV+ VD G S LH ++ A L+KNGA + +ETPL L A S
Sbjct: 1969 DVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQD-NKEETPLFLAAREGS----- 2022
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
+ A+ LL AN ++ D R P V+
Sbjct: 2023 ------YEAAKILLDHFANRDITDHMDRLPRDVA 2050
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/171 (25%), Positives = 71/171 (41%), Gaps = 23/171 (13%)
Query: 251 EADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIK 310
+ D G++AL LA A L+ AD + D G LH + LI+
Sbjct: 1872 QTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIR 1931
Query: 311 NGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQI-------------------AE 351
N A + TPL L A + + A++++ A + E
Sbjct: 1932 NRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVE 1991
Query: 352 A---LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
A LL+ GAN +MQD+K TPL ++ G+ Y +++L + ++ DH
Sbjct: 1992 ATLLLLKNGANRDMQDNKEETPLFLAAREGS-YEAAKILLDHFANRDITDH 2041
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/172 (26%), Positives = 83/172 (48%), Gaps = 13/172 (7%)
Query: 69 DLKIKVGDRHISAHKFVLAARSDSWSL---ANLSSTK--ELDLSDANPEVTMTMLRWIYT 123
D+ + V +R I AH+ VLAA S ++L N+ +K E++L DA P++ ++ + YT
Sbjct: 23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82
Query: 124 DELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLM 183
+ ++V L+ AN++Q++ +++ C + V+ NC+ AE L+ L
Sbjct: 83 ARISVNSNNV--QSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 184 NYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVF 235
+ I H+ ++ K D + L +K T + V ED V+
Sbjct: 141 ATADDFIHQHFTEVYKTD------EFLQLDVKRVTHLLNQDTLTVRAEDQVY 186
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/125 (32%), Positives = 61/125 (48%), Gaps = 12/125 (9%)
Query: 247 GKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAAT 306
G++N+ + G+ L LA+ R + L+ ADV++ D +GW+ LH+ G +
Sbjct: 1146 GRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
Query: 307 FLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSK 366
L+K GA VN + PLH V + + AE LLQ GANPN +D K
Sbjct: 1206 ELLKAGAKVNCENIDG-ILPLH-----------DAVANNHLKAAEILLQNGANPNQKDQK 1253
Query: 367 GRTPL 371
++ L
Sbjct: 1254 QKSAL 1258
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 12/91 (13%)
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+V+ +GW+ LH+ G A+ L+K GA VN L Q TPLH
Sbjct: 514 NVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGL-YQITPLH-----------D 561
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPL 371
VM+ ++AE LL GA+P ++ G+ L
Sbjct: 562 AVMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
Score = 34.3 bits (77), Expect = 0.26
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ------CKQLDLELKDHEGS 402
+ +AL+++GA+ N+ D+ G TPLH + G+ + +LL+ C+ +D L H+
Sbjct: 1170 LVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAV 1229
Query: 403 TALWLAVQHITVSSDQSVN 421
L I + + + N
Sbjct: 1230 ANNHLKAAEILLQNGANPN 1248
Score = 32.7 bits (73), Expect = 0.76
Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 289 GWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQ 348
G +L++K D IK G VN + A T LH ++ +
Sbjct: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSY-AGWTALHEASV-----------GGFYR 536
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
A LL+ GA+ N++ TPLH ++M G+ Y ++LL D ++ +G AL
Sbjct: 537 TASELLKGGADVNIKGLYQITPLHDAVMNGH-YKVAELLLLNGADPLFRNDDGKCAL 592
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/125 (32%), Positives = 61/125 (48%), Gaps = 12/125 (9%)
Query: 247 GKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAAT 306
G++N+ + G+ L LA+ R + L+ ADV++ D +GW+ LH+ G +
Sbjct: 1146 GRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
Query: 307 FLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSK 366
L+K GA VN + PLH V + + AE LLQ GANPN +D K
Sbjct: 1206 ELLKAGAKVNCENIDG-ILPLH-----------DAVANNHLKAAEILLQNGANPNQKDQK 1253
Query: 367 GRTPL 371
++ L
Sbjct: 1254 QKSAL 1258
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 12/91 (13%)
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+V+ +GW+ LH+ G A+ L+K GA VN L Q TPLH
Sbjct: 514 NVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGL-YQITPLH-----------D 561
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPL 371
VM+ ++AE LL GA+P ++ G+ L
Sbjct: 562 AVMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
Score = 34.3 bits (77), Expect = 0.26
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ------CKQLDLELKDHEGS 402
+ +AL+++GA+ N+ D+ G TPLH + G+ + +LL+ C+ +D L H+
Sbjct: 1170 LVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAV 1229
Query: 403 TALWLAVQHITVSSDQSVN 421
L I + + + N
Sbjct: 1230 ANNHLKAAEILLQNGANPN 1248
Score = 32.7 bits (73), Expect = 0.76
Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 289 GWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQ 348
G +L++K D IK G VN + A T LH ++ +
Sbjct: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSY-AGWTALHEASV-----------GGFYR 536
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
A LL+ GA+ N++ TPLH ++M G+ Y ++LL D ++ +G AL
Sbjct: 537 TASELLKGGADVNIKGLYQITPLHDAVMNGH-YKVAELLLLNGADPLFRNDDGKCAL 592
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/125 (32%), Positives = 61/125 (48%), Gaps = 12/125 (9%)
Query: 247 GKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAAT 306
G++N+ + G+ L LA+ R + L+ ADV++ D +GW+ LH+ G +
Sbjct: 1146 GRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIV 1205
Query: 307 FLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSK 366
L+K GA VN + PLH V + + AE LLQ GANPN +D K
Sbjct: 1206 ELLKAGAKVNCENIDG-ILPLH-----------DAVANNHLKAAEILLQNGANPNQKDQK 1253
Query: 367 GRTPL 371
++ L
Sbjct: 1254 QKSAL 1258
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 12/91 (13%)
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+V+ +GW+ LH+ G A+ L+K GA VN L Q TPLH
Sbjct: 514 NVNQPSYAGWTALHEASVGGFYRTASELLKGGADVNIKGL-YQITPLH-----------D 561
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPL 371
VM+ ++AE LL GA+P ++ G+ L
Sbjct: 562 AVMNGHYKVAELLLLNGADPLFRNDDGKCAL 592
Score = 34.3 bits (77), Expect = 0.26
Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ------CKQLDLELKDHEGS 402
+ +AL+++GA+ N+ D+ G TPLH + G+ + +LL+ C+ +D L H+
Sbjct: 1170 LVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAV 1229
Query: 403 TALWLAVQHITVSSDQSVN 421
L I + + + N
Sbjct: 1230 ANNHLKAAEILLQNGANPN 1248
Score = 32.7 bits (73), Expect = 0.76
Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 289 GWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQ 348
G +L++K D IK G VN + A T LH ++ +
Sbjct: 489 GENLVYKAALHDDADLVHHCIKKGGNVNQPSY-AGWTALHEASV-----------GGFYR 536
Query: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
A LL+ GA+ N++ TPLH ++M G+ Y ++LL D ++ +G AL
Sbjct: 537 TASELLKGGADVNIKGLYQITPLHDAVMNGH-YKVAELLLLNGADPLFRNDDGKCAL 592
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 60.8 bits (146), Expect = 3e-09
Identities = 55/209 (26%), Positives = 92/209 (44%), Gaps = 31/209 (14%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V ++L + P +++D G + A + + + T++S K+
Sbjct: 292 PLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 281 DVD--MVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPL-------HLVA 331
D+D M DK G + LH G + L++N A V+A + + TPL H
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV-MKHTPLFRACEMGHKDV 405
Query: 332 LYSSKKHSADV---------------MSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIM 376
+ + K A V + A + + L++ NPN+QD GRTPL +
Sbjct: 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 465
Query: 377 AGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
G + L++ D ++D EG TAL
Sbjct: 466 GGYINCMAVLME-NNADPNIQDKEGRTAL 493
Score = 47.4 bits (111), Expect = 3e-05
Identities = 40/132 (30%), Positives = 59/132 (44%), Gaps = 12/132 (9%)
Query: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH 328
+ + TL+ A VD+VD+ G SLLH G+ LI+N N A TPL
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY-AGRTPLQ 461
Query: 329 LVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
A ++ MA L++ A+PN+QD +GRT LH S G LL
Sbjct: 462 CAAY-------GGYINCMA----VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLD 510
Query: 389 CKQLDLELKDHE 400
+++++E
Sbjct: 511 FAAFPNQMENNE 522
Score = 45.8 bits (107), Expect = 9e-05
Identities = 27/70 (38%), Positives = 40/70 (57%), Gaps = 1/70 (1%)
Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
V+++ A+ALL+AGA+ N D RT LH++ GN Y F +LL ++ + KD E
Sbjct: 56 VLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN-YRFMKLLLTRRANWMQKDLEE 114
Query: 402 STALWLAVQH 411
T L L +H
Sbjct: 115 MTPLHLTTRH 124
Score = 37.4 bits (85), Expect = 0.031
Identities = 56/229 (24%), Positives = 87/229 (37%), Gaps = 32/229 (13%)
Query: 186 CAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQL 245
CA+ + D+ K D S +A + K Y K + R + + L EM
Sbjct: 63 CADALLKAGADVNKTDHSQRTA---LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP-- 117
Query: 246 PGKLNEADHNGDLALDLALSRRLESIATTLVSHKA--DVDMVDKSGWSLLHKGIQRGDLF 303
L L R L+ A +VD DK+ + LH +
Sbjct: 118 --------------LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPE 163
Query: 304 AATFLIKNGAFVNAATLGAQETPLHLVALYS--SKKHSADVMSEMAQIAEALLQAGANPN 361
LIK+ + + + + PLH A + S H+ + + A E+LL N
Sbjct: 164 HVKLLIKHDSNIGIPDVEGK-IPLHWAANHKDPSAVHTVRCILDAAP-TESLL------N 215
Query: 362 MQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL-WLAV 409
QD +GRTPLH ++ GN V L + ++ D+ T L W A+
Sbjct: 216 WQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 264
Score = 33.5 bits (75), Expect = 0.45
Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 334 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 393
+S+ H+A V + + ++ A + +D GRTPL ++A LL+ D
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GAD 73
Query: 394 LELKDHEGSTALWLAVQ 410
+ DH TAL LA Q
Sbjct: 74 VNKTDHSQRTALHLAAQ 90
Score = 30.8 bits (68), Expect = 2.9
Identities = 29/107 (27%), Positives = 42/107 (39%), Gaps = 2/107 (1%)
Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI 309
N D+ G L A + L+ + AD ++ DK G + LH G L A L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Query: 310 KNGAFVNAATLGAQE-TPLHLVALYSSKKHSADVMSEMAQIAEALLQ 355
AF N + TPL AL + M E ++ A +Q
Sbjct: 510 DFAAFPNQMENNEERYTPLD-YALLGERHEVIQFMLEHGALSIAAIQ 555
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 60.8 bits (146), Expect = 3e-09
Identities = 55/209 (26%), Positives = 92/209 (44%), Gaps = 31/209 (14%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V ++L + P +++D G + A + + + T++S K+
Sbjct: 292 PLHYAAQSNFAETVKVFL-----KHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 281 DVD--MVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPL-------HLVA 331
D+D M DK G + LH G + L++N A V+A + + TPL H
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDV-MKHTPLFRACEMGHKDV 405
Query: 332 LYSSKKHSADV---------------MSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIM 376
+ + K A V + A + + L++ NPN+QD GRTPL +
Sbjct: 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 465
Query: 377 AGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
G + L++ D ++D EG TAL
Sbjct: 466 GGYINCMAVLME-NNADPNIQDKEGRTAL 493
Score = 47.4 bits (111), Expect = 3e-05
Identities = 40/132 (30%), Positives = 59/132 (44%), Gaps = 12/132 (9%)
Query: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH 328
+ + TL+ A VD+VD+ G SLLH G+ LI+N N A TPL
Sbjct: 403 KDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDY-AGRTPLQ 461
Query: 329 LVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
A ++ MA L++ A+PN+QD +GRT LH S G LL
Sbjct: 462 CAAY-------GGYINCMA----VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLD 510
Query: 389 CKQLDLELKDHE 400
+++++E
Sbjct: 511 FAAFPNQMENNE 522
Score = 45.8 bits (107), Expect = 9e-05
Identities = 27/70 (38%), Positives = 40/70 (57%), Gaps = 1/70 (1%)
Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
V+++ A+ALL+AGA+ N D RT LH++ GN Y F +LL ++ + KD E
Sbjct: 56 VLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN-YRFMKLLLTRRANWMQKDLEE 114
Query: 402 STALWLAVQH 411
T L L +H
Sbjct: 115 MTPLHLTTRH 124
Score = 37.4 bits (85), Expect = 0.031
Identities = 56/229 (24%), Positives = 87/229 (37%), Gaps = 32/229 (13%)
Query: 186 CAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQL 245
CA+ + D+ K D S +A + K Y K + R + + L EM
Sbjct: 63 CADALLKAGADVNKTDHSQRTA---LHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTP-- 117
Query: 246 PGKLNEADHNGDLALDLALSRRLESIATTLVSHKA--DVDMVDKSGWSLLHKGIQRGDLF 303
L L R L+ A +VD DK+ + LH +
Sbjct: 118 --------------LHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPE 163
Query: 304 AATFLIKNGAFVNAATLGAQETPLHLVALYS--SKKHSADVMSEMAQIAEALLQAGANPN 361
LIK+ + + + + PLH A + S H+ + + A E+LL N
Sbjct: 164 HVKLLIKHDSNIGIPDVEGK-IPLHWAANHKDPSAVHTVRCILDAAP-TESLL------N 215
Query: 362 MQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL-WLAV 409
QD +GRTPLH ++ GN V L + ++ D+ T L W A+
Sbjct: 216 WQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 264
Score = 33.5 bits (75), Expect = 0.45
Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 334 SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 393
+S+ H+A V + + ++ A + +D GRTPL ++A LL+ D
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA-GAD 73
Query: 394 LELKDHEGSTALWLAVQ 410
+ DH TAL LA Q
Sbjct: 74 VNKTDHSQRTALHLAAQ 90
Score = 30.8 bits (68), Expect = 2.9
Identities = 29/107 (27%), Positives = 42/107 (39%), Gaps = 2/107 (1%)
Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI 309
N D+ G L A + L+ + AD ++ DK G + LH G L A L+
Sbjct: 450 NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 509
Query: 310 KNGAFVNAATLGAQE-TPLHLVALYSSKKHSADVMSEMAQIAEALLQ 355
AF N + TPL AL + M E ++ A +Q
Sbjct: 510 DFAAFPNQMENNEERYTPLD-YALLGERHEVIQFMLEHGALSIAAIQ 555
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 60.5 bits (145), Expect = 3e-09
Identities = 41/182 (22%), Positives = 90/182 (49%), Gaps = 15/182 (8%)
Query: 60 DLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSST-----KELDLSDANPEVT 114
DL +++++ D +K GD+ + H+ +L+A S + LS KE+ L + +P +
Sbjct: 25 DLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAIL 84
Query: 115 MTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTA 174
+++++Y+ ++ + +V ++ LA+RFQ+ + C + + NC+ +
Sbjct: 85 DLIIKYLYSASIDLNDGNV--QDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
Query: 175 EELNASTLMNYCAEIIASHWDDL-RKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDV 233
L+ L E ++ + + ++EDF +S Q L +I + ++ VE+E+
Sbjct: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVIS-------NDSLNVEKEEA 195
Query: 234 VF 235
VF
Sbjct: 196 VF 197
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/180 (31%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K + +V L Q G N G L LA + L+S +A
Sbjct: 638 PLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK--- 337
+ ++ +KSG + LH Q G + A LIK+G V+A T TPLH+ + Y + K
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 751
Query: 338 ----HSADV----------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
H ADV + + AQ I LL+ GA+PN S G TPL ++ G
Sbjct: 752 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 811
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I++KT+ P+H A + + D V L L Q ++++ + L +A
Sbjct: 331 IQAKTKNGLSPIHMAAQGDHLDCVRLLL-----QYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ A + +G++ LH ++ + L+K GA ++A T TPLH+
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHV- 443
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
A M + I + LLQ GA+PN+ + K TPLH++ AG+ V LLQ K
Sbjct: 444 ---------ASFMGHLP-IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
Query: 391 -QLDLELKDHE 400
+++ + KD +
Sbjct: 494 AKVNAKAKDDQ 504
Score = 53.1 bits (126), Expect = 5e-07
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 24/186 (12%)
Query: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATF 307
K N NG L +A + + L+ A +D V +SG + LH G L
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
Query: 308 LIKNGAFVNAATLGAQETPLHLVA-----------LYSSKKHSADVMSEMAQI------- 349
L++ GA N + + ETPLH+ A L + K +A + +
Sbjct: 456 LLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
Query: 350 ----AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
+ LL+ ANPN+ + G TPLH++ G+ LL+ K+ +G T L
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQACMTKKGFTPL 573
Query: 406 WLAVQH 411
+A ++
Sbjct: 574 HVAAKY 579
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/215 (25%), Positives = 84/215 (39%), Gaps = 25/215 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L + SQ G L +A +A L+ A
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G + LH + +L L+ G ++ TPLH+ A
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIAA--------- 643
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
++A +LLQ G + N + +G TPLH++ G+ + + LL KQ + L +
Sbjct: 644 --KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKS 700
Query: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
G T L L Q V P DV + +G D
Sbjct: 701 GLTPLHLVAQEGHV-------PVADVLIKHGVMVD 728
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
L G+ AL +A + + LV++ A+V+ + G++ L+ Q L FL
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 309 IKNGAFVNAAT------------LGAQETPLHLVALYSSKK------HSADVMSEMAQIA 350
++NGA N AT G + HL+ + K H A ++ + A
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA-ARNDDTRTA 222
Query: 351 EALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
LLQ NP++ G TPLH++ N V +QLL + + G T L +A
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV-AQLLLNRGASVNFTPQNGITPLHIA 279
Score = 49.7 bits (117), Expect = 6e-06
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 217 KTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLV 276
K E PLH A + +V YL+ Q K+N + L A ++ L+
Sbjct: 469 KVETPLHMAARAGHTEVA-KYLL----QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 523
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
+ A+ ++ +G + LH + G + L++ A A TPLH+ A Y
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGK- 581
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++AE LL+ A+PN G TPLHV++ N + LL
Sbjct: 582 ----------VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 24/193 (12%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ D+V L L G + NG L +A + +A +L+ +
Sbjct: 605 PLHVAVHHNNLDIVKLLLPR-----GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIK---NGAFVNAATLGAQETPLHLVALYSSKK 337
+ G + LH Q G L+ NG N + L TPLHLVA
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----TPLHLVA------ 709
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+A+ L++ G + G TPLHV+ GN + LLQ Q D+ K
Sbjct: 710 -----QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAK 763
Query: 398 DHEGSTALWLAVQ 410
G + L A Q
Sbjct: 764 TKLGYSPLHQAAQ 776
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 12/139 (8%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 71 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 131 VNYGANVNAQSQKG-FTPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 178
Query: 369 TPLHVSIMAGNEYVFSQLL 387
TPL V++ G+E V + L+
Sbjct: 179 TPLAVALQQGHENVVAHLI 197
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 199 KEDFSSMSAQLLYKMIKSKTEYP-LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGD 257
++ ++ A L+ K K P LH I +D ++ + P L++ G
Sbjct: 186 QQGHENVVAHLINYGTKGKVRLPALH--IAARNDDTRTAAVLLQNDPNPDVLSKT---GF 240
Query: 258 LALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
L +A ++A L++ A V+ ++G + LH +RG++ L+ GA +
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 318 ATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
T + TPLH A + +I+E LL GA + G +P+H++
Sbjct: 301 KTKD-ELTPLHCAA-----------RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348
Query: 378 GNEYVFSQLLQCKQLDLELKD 398
+ LL Q D E+ D
Sbjct: 349 DHLDCVRLLL---QYDAEIDD 366
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/180 (31%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K + +V L Q G N G L LA + L+S +A
Sbjct: 605 PLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK--- 337
+ ++ +KSG + LH Q G + A LIK+G V+A T TPLH+ + Y + K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 338 ----HSADV----------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
H ADV + + AQ I LL+ GA+PN S G TPL ++ G
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I++KT+ P+H A + + D V L L Q ++++ + L +A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLL-----QYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ A + +G++ LH ++ + L+K GA ++A T TPLH+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHV- 410
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
A M + I + LLQ GA+PN+ + K TPLH++ AG+ V LLQ K
Sbjct: 411 ---------ASFMGHLP-IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 391 -QLDLELKDHE 400
+++ + KD +
Sbjct: 461 AKVNAKAKDDQ 471
Score = 53.1 bits (126), Expect = 5e-07
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 24/186 (12%)
Query: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATF 307
K N NG L +A + + L+ A +D V +SG + LH G L
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 308 LIKNGAFVNAATLGAQETPLHLVA-----------LYSSKKHSADVMSEMAQI------- 349
L++ GA N + + ETPLH+ A L + K +A + +
Sbjct: 423 LLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 350 ----AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
+ LL+ ANPN+ + G TPLH++ G+ LL+ K+ +G T L
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQACMTKKGFTPL 540
Query: 406 WLAVQH 411
+A ++
Sbjct: 541 HVAAKY 546
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/215 (25%), Positives = 84/215 (39%), Gaps = 25/215 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L + SQ G L +A +A L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G + LH + +L L+ G ++ TPLH+ A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIAA--------- 610
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
++A +LLQ G + N + +G TPLH++ G+ + + LL KQ + L +
Sbjct: 611 --KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKS 667
Query: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
G T L L Q V P DV + +G D
Sbjct: 668 GLTPLHLVAQEGHV-------PVADVLIKHGVMVD 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
L G+ AL +A + + LV++ A+V+ + G++ L+ Q L FL
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 309 IKNGAFVNAAT------------LGAQETPLHLVALYSSKK------HSADVMSEMAQIA 350
++NGA N AT G + HL+ + K H A ++ + A
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA-ARNDDTRTA 189
Query: 351 EALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
LLQ NP++ G TPLH++ N V +QLL + + G T L +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV-AQLLLNRGASVNFTPQNGITPLHIA 246
Score = 49.7 bits (117), Expect = 6e-06
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 217 KTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLV 276
K E PLH A + +V YL+ Q K+N + L A ++ L+
Sbjct: 436 KVETPLHMAARAGHTEVA-KYLL----QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
+ A+ ++ +G + LH + G + L++ A A TPLH+ A Y
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGK- 548
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++AE LL+ A+PN G TPLHV++ N + LL
Sbjct: 549 ----------VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 24/193 (12%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ D+V L L G + NG L +A + +A +L+ +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPR-----GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIK---NGAFVNAATLGAQETPLHLVALYSSKK 337
+ G + LH Q G L+ NG N + L TPLHLVA
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----TPLHLVA------ 676
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+A+ L++ G + G TPLHV+ GN + LLQ Q D+ K
Sbjct: 677 -----QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAK 730
Query: 398 DHEGSTALWLAVQ 410
G + L A Q
Sbjct: 731 TKLGYSPLHQAAQ 743
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 12/139 (8%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 98 VNYGANVNAQSQKG-FTPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
Query: 369 TPLHVSIMAGNEYVFSQLL 387
TPL V++ G+E V + L+
Sbjct: 146 TPLAVALQQGHENVVAHLI 164
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 199 KEDFSSMSAQLLYKMIKSKTEYP-LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGD 257
++ ++ A L+ K K P LH I +D ++ + P L++ G
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALH--IAARNDDTRTAAVLLQNDPNPDVLSKT---GF 207
Query: 258 LALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
L +A ++A L++ A V+ ++G + LH +RG++ L+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 318 ATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
T + TPLH A + +I+E LL GA + G +P+H++
Sbjct: 268 KTKD-ELTPLHCAA-----------RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 378 GNEYVFSQLLQCKQLDLELKD 398
+ LL Q D E+ D
Sbjct: 316 DHLDCVRLLL---QYDAEIDD 333
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/180 (31%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K + +V L Q G N G L LA + L+S +A
Sbjct: 605 PLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK--- 337
+ ++ +KSG + LH Q G + A LIK+G V+A T TPLH+ + Y + K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 338 ----HSADV----------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
H ADV + + AQ I LL+ GA+PN S G TPL ++ G
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I++KT+ P+H A + + D V L L Q ++++ + L +A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLL-----QYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ A + +G++ LH ++ + L+K GA ++A T TPLH+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHV- 410
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
A M + I + LLQ GA+PN+ + K TPLH++ AG+ V LLQ K
Sbjct: 411 ---------ASFMGHLP-IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 391 -QLDLELKDHE 400
+++ + KD +
Sbjct: 461 AKVNAKAKDDQ 471
Score = 53.1 bits (126), Expect = 5e-07
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 24/186 (12%)
Query: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATF 307
K N NG L +A + + L+ A +D V +SG + LH G L
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 308 LIKNGAFVNAATLGAQETPLHLVA-----------LYSSKKHSADVMSEMAQI------- 349
L++ GA N + + ETPLH+ A L + K +A + +
Sbjct: 423 LLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 350 ----AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
+ LL+ ANPN+ + G TPLH++ G+ LL+ K+ +G T L
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQACMTKKGFTPL 540
Query: 406 WLAVQH 411
+A ++
Sbjct: 541 HVAAKY 546
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/215 (25%), Positives = 84/215 (39%), Gaps = 25/215 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L + SQ G L +A +A L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G + LH + +L L+ G ++ TPLH+ A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIAA--------- 610
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
++A +LLQ G + N + +G TPLH++ G+ + + LL KQ + L +
Sbjct: 611 --KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKS 667
Query: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
G T L L Q V P DV + +G D
Sbjct: 668 GLTPLHLVAQEGHV-------PVADVLIKHGVMVD 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
L G+ AL +A + + LV++ A+V+ + G++ L+ Q L FL
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 309 IKNGAFVNAAT------------LGAQETPLHLVALYSSKK------HSADVMSEMAQIA 350
++NGA N AT G + HL+ + K H A ++ + A
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA-ARNDDTRTA 189
Query: 351 EALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
LLQ NP++ G TPLH++ N V +QLL + + G T L +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV-AQLLLNRGASVNFTPQNGITPLHIA 246
Score = 49.7 bits (117), Expect = 6e-06
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 217 KTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLV 276
K E PLH A + +V YL+ Q K+N + L A ++ L+
Sbjct: 436 KVETPLHMAARAGHTEVA-KYLL----QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
+ A+ ++ +G + LH + G + L++ A A TPLH+ A Y
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGK- 548
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++AE LL+ A+PN G TPLHV++ N + LL
Sbjct: 549 ----------VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 24/193 (12%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ D+V L L G + NG L +A + +A +L+ +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPR-----GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIK---NGAFVNAATLGAQETPLHLVALYSSKK 337
+ G + LH Q G L+ NG N + L TPLHLVA
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----TPLHLVA------ 676
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+A+ L++ G + G TPLHV+ GN + LLQ Q D+ K
Sbjct: 677 -----QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAK 730
Query: 398 DHEGSTALWLAVQ 410
G + L A Q
Sbjct: 731 TKLGYSPLHQAAQ 743
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 12/139 (8%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 98 VNYGANVNAQSQKG-FTPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
Query: 369 TPLHVSIMAGNEYVFSQLL 387
TPL V++ G+E V + L+
Sbjct: 146 TPLAVALQQGHENVVAHLI 164
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 199 KEDFSSMSAQLLYKMIKSKTEYP-LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGD 257
++ ++ A L+ K K P LH I +D ++ + P L++ G
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALH--IAARNDDTRTAAVLLQNDPNPDVLSKT---GF 207
Query: 258 LALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
L +A ++A L++ A V+ ++G + LH +RG++ L+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 318 ATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
T + TPLH A + +I+E LL GA + G +P+H++
Sbjct: 268 KTKD-ELTPLHCAA-----------RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 378 GNEYVFSQLLQCKQLDLELKD 398
+ LL Q D E+ D
Sbjct: 316 DHLDCVRLLL---QYDAEIDD 333
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/180 (31%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K + +V L Q G N G L LA + L+S +A
Sbjct: 605 PLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK--- 337
+ ++ +KSG + LH Q G + A LIK+G V+A T TPLH+ + Y + K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 338 ----HSADV----------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
H ADV + + AQ I LL+ GA+PN S G TPL ++ G
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I++KT+ P+H A + + D V L L Q ++++ + L +A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLL-----QYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ A + +G++ LH ++ + L+K GA ++A T TPLH+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHV- 410
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
A M + I + LLQ GA+PN+ + K TPLH++ AG+ V LLQ K
Sbjct: 411 ---------ASFMGHLP-IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 391 -QLDLELKDHE 400
+++ + KD +
Sbjct: 461 AKVNAKAKDDQ 471
Score = 53.1 bits (126), Expect = 5e-07
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 24/186 (12%)
Query: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATF 307
K N NG L +A + + L+ A +D V +SG + LH G L
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 308 LIKNGAFVNAATLGAQETPLHLVA-----------LYSSKKHSADVMSEMAQI------- 349
L++ GA N + + ETPLH+ A L + K +A + +
Sbjct: 423 LLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 350 ----AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
+ LL+ ANPN+ + G TPLH++ G+ LL+ K+ +G T L
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQACMTKKGFTPL 540
Query: 406 WLAVQH 411
+A ++
Sbjct: 541 HVAAKY 546
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/215 (25%), Positives = 84/215 (39%), Gaps = 25/215 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L + SQ G L +A +A L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G + LH + +L L+ G ++ TPLH+ A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIAA--------- 610
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
++A +LLQ G + N + +G TPLH++ G+ + + LL KQ + L +
Sbjct: 611 --KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKS 667
Query: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
G T L L Q V P DV + +G D
Sbjct: 668 GLTPLHLVAQEGHV-------PVADVLIKHGVMVD 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
L G+ AL +A + + LV++ A+V+ + G++ L+ Q L FL
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 309 IKNGAFVNAAT------------LGAQETPLHLVALYSSKK------HSADVMSEMAQIA 350
++NGA N AT G + HL+ + K H A ++ + A
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA-ARNDDTRTA 189
Query: 351 EALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
LLQ NP++ G TPLH++ N V +QLL + + G T L +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV-AQLLLNRGASVNFTPQNGITPLHIA 246
Score = 49.7 bits (117), Expect = 6e-06
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 217 KTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLV 276
K E PLH A + +V YL+ Q K+N + L A ++ L+
Sbjct: 436 KVETPLHMAARAGHTEVA-KYLL----QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
+ A+ ++ +G + LH + G + L++ A A TPLH+ A Y
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGK- 548
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++AE LL+ A+PN G TPLHV++ N + LL
Sbjct: 549 ----------VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 24/193 (12%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ D+V L L G + NG L +A + +A +L+ +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPR-----GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIK---NGAFVNAATLGAQETPLHLVALYSSKK 337
+ G + LH Q G L+ NG N + L TPLHLVA
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----TPLHLVA------ 676
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+A+ L++ G + G TPLHV+ GN + LLQ Q D+ K
Sbjct: 677 -----QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAK 730
Query: 398 DHEGSTALWLAVQ 410
G + L A Q
Sbjct: 731 TKLGYSPLHQAAQ 743
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 12/139 (8%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 98 VNYGANVNAQSQKG-FTPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
Query: 369 TPLHVSIMAGNEYVFSQLL 387
TPL V++ G+E V + L+
Sbjct: 146 TPLAVALQQGHENVVAHLI 164
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 199 KEDFSSMSAQLLYKMIKSKTEYP-LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGD 257
++ ++ A L+ K K P LH I +D ++ + P L++ G
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALH--IAARNDDTRTAAVLLQNDPNPDVLSKT---GF 207
Query: 258 LALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
L +A ++A L++ A V+ ++G + LH +RG++ L+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 318 ATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
T + TPLH A + +I+E LL GA + G +P+H++
Sbjct: 268 KTKD-ELTPLHCAA-----------RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 378 GNEYVFSQLLQCKQLDLELKD 398
+ LL Q D E+ D
Sbjct: 316 DHLDCVRLLL---QYDAEIDD 333
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/180 (31%), Positives = 79/180 (43%), Gaps = 28/180 (15%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A K + +V L Q G N G L LA + L+S +A
Sbjct: 605 PLHIAAKQNQVEVARSLL-----QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK--- 337
+ ++ +KSG + LH Q G + A LIK+G V+A T TPLH+ + Y + K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 338 ----HSADV----------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
H ADV + + AQ I LL+ GA+PN S G TPL ++ G
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/191 (27%), Positives = 91/191 (47%), Gaps = 21/191 (10%)
Query: 214 IKSKTEY---PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
I++KT+ P+H A + + D V L L Q ++++ + L +A
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLL-----QYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
+A L+ A + +G++ LH ++ + L+K GA ++A T TPLH+
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-TPLHV- 410
Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
A M + I + LLQ GA+PN+ + K TPLH++ AG+ V LLQ K
Sbjct: 411 ---------ASFMGHLP-IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 391 -QLDLELKDHE 400
+++ + KD +
Sbjct: 461 AKVNAKAKDDQ 471
Score = 53.1 bits (126), Expect = 5e-07
Identities = 48/186 (25%), Positives = 77/186 (41%), Gaps = 24/186 (12%)
Query: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATF 307
K N NG L +A + + L+ A +D V +SG + LH G L
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 308 LIKNGAFVNAATLGAQETPLHLVA-----------LYSSKKHSADVMSEMAQI------- 349
L++ GA N + + ETPLH+ A L + K +A + +
Sbjct: 423 LLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 350 ----AEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL 405
+ LL+ ANPN+ + G TPLH++ G+ LL+ K+ +G T L
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE-KEASQACMTKKGFTPL 540
Query: 406 WLAVQH 411
+A ++
Sbjct: 541 HVAAKY 546
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/215 (25%), Positives = 84/215 (39%), Gaps = 25/215 (11%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A + + V L + SQ G L +A +A L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQAC-----MTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
+ K+G + LH + +L L+ G ++ TPLH+ A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY-TPLHIAA--------- 610
Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
++A +LLQ G + N + +G TPLH++ G+ + + LL KQ + L +
Sbjct: 611 --KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKS 667
Query: 401 GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
G T L L Q V P DV + +G D
Sbjct: 668 GLTPLHLVAQEGHV-------PVADVLIKHGVMVD 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 20/178 (11%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
L G+ AL +A + + LV++ A+V+ + G++ L+ Q L FL
Sbjct: 71 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 309 IKNGAFVNAAT------------LGAQETPLHLVALYSSKK------HSADVMSEMAQIA 350
++NGA N AT G + HL+ + K H A ++ + A
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIA-ARNDDTRTA 189
Query: 351 EALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
LLQ NP++ G TPLH++ N V +QLL + + G T L +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV-AQLLLNRGASVNFTPQNGITPLHIA 246
Score = 49.7 bits (117), Expect = 6e-06
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 17/171 (9%)
Query: 217 KTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLV 276
K E PLH A + +V YL+ Q K+N + L A ++ L+
Sbjct: 436 KVETPLHMAARAGHTEVA-KYLL----QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 277 SHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK 336
+ A+ ++ +G + LH + G + L++ A A TPLH+ A Y
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGK- 548
Query: 337 KHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
++AE LL+ A+PN G TPLHV++ N + LL
Sbjct: 549 ----------VRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/193 (27%), Positives = 75/193 (38%), Gaps = 24/193 (12%)
Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
PLH A+ D+V L L G + NG L +A + +A +L+ +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPR-----GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIK---NGAFVNAATLGAQETPLHLVALYSSKK 337
+ G + LH Q G L+ NG N + L TPLHLVA
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL----TPLHLVA------ 676
Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
+A+ L++ G + G TPLHV+ GN + LLQ Q D+ K
Sbjct: 677 -----QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAK 730
Query: 398 DHEGSTALWLAVQ 410
G + L A Q
Sbjct: 731 TKLGYSPLHQAAQ 743
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 12/139 (8%)
Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
+N + NG L LA + L+ + ++ K G + LH G L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
+ GA VNA + TPL++ A ++ + LL+ GAN N+ G
Sbjct: 98 VNYGANVNAQSQKG-FTPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145
Query: 369 TPLHVSIMAGNEYVFSQLL 387
TPL V++ G+E V + L+
Sbjct: 146 TPLAVALQQGHENVVAHLI 164
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 21/201 (10%)
Query: 199 KEDFSSMSAQLLYKMIKSKTEYP-LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGD 257
++ ++ A L+ K K P LH I +D ++ + P L++ G
Sbjct: 153 QQGHENVVAHLINYGTKGKVRLPALH--IAARNDDTRTAAVLLQNDPNPDVLSKT---GF 207
Query: 258 LALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNA 317
L +A ++A L++ A V+ ++G + LH +RG++ L+ GA +
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 318 ATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMA 377
T + TPLH A + +I+E LL GA + G +P+H++
Sbjct: 268 KTKD-ELTPLHCAA-----------RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 378 GNEYVFSQLLQCKQLDLELKD 398
+ LL Q D E+ D
Sbjct: 316 DHLDCVRLLL---QYDAEIDD 333
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/132 (32%), Positives = 61/132 (46%), Gaps = 12/132 (9%)
Query: 243 SQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDL 302
S+ K+N+ + G+ L A R L+S ADV++ D +GW+ LH+ RG
Sbjct: 155 SKTKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYY 214
Query: 303 FAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNM 362
A L+ GA VN L +TPLH A K + + LL+ G NP
Sbjct: 215 DVAKQLLAAGAEVNTKGLD-DDTPLHDAANNGHYK-----------VVKLLLRYGGNPQQ 262
Query: 363 QDSKGRTPLHVS 374
+ KG TPL V+
Sbjct: 263 SNRKGETPLKVA 274
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,852,892
Number of Sequences: 37866
Number of extensions: 619357
Number of successful extensions: 4432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 275
Number of HSP's successfully gapped in prelim test: 193
Number of HSP's that attempted gapping in prelim test: 2507
Number of HSP's gapped (non-prelim): 1310
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.