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Search of human proteins with 30181233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30181233 leucine-rich repeats and calponin homology (CH)
domain containing 4 [Homo sapiens]
(683 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 1356 0.0
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 430 e-120
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 415 e-116
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 302 6e-82
gi|61742786 leucine rich repeat and death domain containing prot... 116 6e-26
gi|61742784 leucine rich repeat and death domain containing prot... 116 6e-26
gi|61742782 leucine rich repeat and death domain containing prot... 105 2e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 104 3e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 103 7e-22
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 102 9e-22
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 99 1e-20
gi|53729363 leucine rich repeat and sterile alpha motif containi... 99 1e-20
gi|53729361 leucine rich repeat and sterile alpha motif containi... 99 1e-20
gi|53729359 leucine rich repeat and sterile alpha motif containi... 99 1e-20
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 99 2e-20
gi|238908508 leucine-rich repeat and death domain-containing pro... 98 2e-20
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 98 3e-20
gi|45827729 scribble isoform b [Homo sapiens] 97 5e-20
gi|45827731 scribble isoform a [Homo sapiens] 97 5e-20
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 97 6e-20
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 95 2e-19
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 94 4e-19
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 94 4e-19
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 92 2e-18
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 91 5e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 90 6e-18
gi|197333706 leucine rich repeat containing 8 family, member D [... 88 3e-17
gi|34222199 leucine rich repeat containing 8 family, member D [H... 88 3e-17
gi|4503743 flightless I homolog [Homo sapiens] 87 4e-17
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 86 9e-17
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 1356 bits (3509), Expect = 0.0
Identities = 683/683 (100%), Positives = 683/683 (100%)
Query: 1 MAAAVAAPLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRG 60
MAAAVAAPLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRG
Sbjct: 1 MAAAVAAPLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRG 60
Query: 61 AARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLN 120
AARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLN
Sbjct: 61 AARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLN 120
Query: 121 LSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCG 180
LSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCG
Sbjct: 121 LSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCG 180
Query: 181 LSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQ 240
LSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQ
Sbjct: 181 LSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQ 240
Query: 241 SPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDS 300
SPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDS
Sbjct: 241 SPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDS 300
Query: 301 GFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSH 360
GFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSH
Sbjct: 301 GFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSH 360
Query: 361 VPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQ 420
VPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQ
Sbjct: 361 VPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQ 420
Query: 421 QSGAWGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNGSPKSSASQAGAAAGQGAPAPAPAS 480
QSGAWGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNGSPKSSASQAGAAAGQGAPAPAPAS
Sbjct: 421 QSGAWGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNGSPKSSASQAGAAAGQGAPAPAPAS 480
Query: 481 QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDL 540
QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDL
Sbjct: 481 QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDL 540
Query: 541 MTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKA 600
MTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKA
Sbjct: 541 MTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKA 600
Query: 601 RKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLRTALEAVKRVGGKALPPLWPPSGLG 660
RKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLRTALEAVKRVGGKALPPLWPPSGLG
Sbjct: 601 RKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLRTALEAVKRVGGKALPPLWPPSGLG 660
Query: 661 GFVVFYVVLMLLLYVTYTRLLGS 683
GFVVFYVVLMLLLYVTYTRLLGS
Sbjct: 661 GFVVFYVVLMLLLYVTYTRLLGS 683
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 430 bits (1105), Expect = e-120
Identities = 298/712 (41%), Positives = 389/712 (54%), Gaps = 72/712 (10%)
Query: 7 APLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYD 66
AP AGG + G LP R ERALEEA +G LNLS R+LK FPR AA +D
Sbjct: 41 APGGAGGGGGGS-----GGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHD 95
Query: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
LSD QADLS+NR EVP C VSLE L+LYHNC+R + A+ NL LTYLNLSRNQL
Sbjct: 96 LSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQL 155
Query: 127 SLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRD 186
S LP +C LPL+VLI SNNKLG+LP +IG L L +LDVS NE+ +LP ++ L SLR+
Sbjct: 156 SALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRE 215
Query: 187 LNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
LNVRRN L LP+EL DLPLV+ DFSCN+V IP+ F ++ LQV+LL++NPLQSPPAQ+
Sbjct: 216 LNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQI 275
Query: 247 CLKGKLHIFKYLSTEAGQ--RGSALGDLAPSRPPSFSPCPAEDLFPGHRYDG--GLDSGF 302
C KGK+HIFKYLS +A Q +L RP H DG DSG
Sbjct: 276 CTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQ----------HVEDGKKDSDSGV 325
Query: 303 HSVDSGSKRWSGNESTDEFS-ELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHV 361
S D+G KR S E +DE + L+ +S + E + KED PV+ +F
Sbjct: 326 GS-DNGDKRLSATEPSDEDTVSLNVPMSNIMEE---EQIIKEDSCHRLSPVKGEFHQEFQ 381
Query: 362 P-----GEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERER 416
P G+ G +Q +RA E + R D +L + E
Sbjct: 382 PEPSLLGDSTNSGEERDQ----------FTDRA-DGLHSEFMNYKARAEDCEELLRIEED 430
Query: 417 RQQQQSGAWGAPR---KDSLLKPGLRAVV-------GGAAAVSTQAMHNGSPKSSAS--- 463
Q G + + D + LR V G + ++ +++ N P SA
Sbjct: 431 VHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALE 490
Query: 464 -QAGAAAGQGAPAPAPAS--QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPS 520
Q A GQ +P Q L + + +P + S S++ G P
Sbjct: 491 LQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTNSTAPFGLKPR 550
Query: 521 S-------------PDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALASG 567
S P +R R+ Q+ +EK+L+ QLR+ +E RL+ L EDL AL G
Sbjct: 551 SVFLRPQRNLESIDPQFTIR-RKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDG 609
Query: 568 VILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLCSPSDL 627
V+LC L N +RPRSV IHVPSPAVPKLS K R+NVE+FLEACRK+GVPEADLCSP D+
Sbjct: 610 VVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDI 669
Query: 628 LQGTARGLRTALEAVKRVGGKALPP--LWPPSGLGGFVVFYVVLMLLLYVTY 677
LQ R +R ++ + +G KA PP L GF + +++ ++L+Y+TY
Sbjct: 670 LQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITY 721
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 415 bits (1066), Expect = e-116
Identities = 291/717 (40%), Positives = 375/717 (52%), Gaps = 132/717 (18%)
Query: 1 MAAAVAAPLAAGGEEAAATTSVPGSPGL-------------PGR--RSAERALEEAVATG 45
MAAA +AA E + S PG+ PG RS +RALEEA TG
Sbjct: 1 MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG 60
Query: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRC 105
L+LS R+L+ FPRGAA ++DL+D T+ADLSRNR E+P AC VSLE L+LY NC+R
Sbjct: 61 VLSLSGRKLREFPRGAA-NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRY 119
Query: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+ A+ NL ALT+LN+SRNQLS LP ++C LPL+VLI SNNKL +LP +IG L L +LD
Sbjct: 120 IPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELD 179
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCR 225
VS NE+Q++PS++ L +LRDLNVRRN L LPEEL +LPL+RLDFSCN+++ IPV +
Sbjct: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRN 239
Query: 226 LRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPA 285
LRHLQ I LD+NPLQSPPAQ+C+KGK+HIFKYL+ +A + L D RP F C
Sbjct: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDY-DRRPLGFGSCH- 297
Query: 286 EDLFPGHRYDGGLDSGFHSVDSGSKRWSGNESTDEFSELSFRISELA------------- 332
E+L+ Y G LDSGF+SVDSG KRWSGNE TDEFS+L R++E+
Sbjct: 298 EELYSSRPY-GALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQE 356
Query: 333 ----------------------------------REPRGPRERKEDG-----------SA 347
R+P+GP S
Sbjct: 357 NRGSLVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISH 416
Query: 348 DGDPVQIDFIDSHVPGEDEERGTVEEQRPPE----LSPGAGDRERAPSS-----RREEPA 398
+G PV+ I ED R + + P E LS A + + + RRE+
Sbjct: 417 EGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLV 476
Query: 399 GEERRRPD--TLQLWQERERRQQQQSGA------WGAPRKDSLLKPGLRAVVGGAAAVST 450
RR LQ +E+ R +Q Q A A + P L V G S
Sbjct: 477 ERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSR 536
Query: 451 QAMHNGSPKSSASQAGA-AAGQGAPAPAPASQEPLP--------IAGPATA--------- 492
++ H S +G G A P ++ PL ++ PAT
Sbjct: 537 RSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYS 596
Query: 493 -PAPRPLGSIQRPNSFLFRSS--SQSGSGPSSPDSVLRPRRYP--------------QVP 535
PA QRP SFLFR+ +++ G +SP L P P Q
Sbjct: 597 FPAAIQRNQPQRPESFLFRAGVRAETNKGHASP---LPPSAAPTTDSTDSITGQNSRQRE 653
Query: 536 DEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAV 592
+E +L+ QLR+ +E RL+ LP DL AL GV+LC LAN +RPRSVP IHVPSPAV
Sbjct: 654 EELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 302 bits (774), Expect = 6e-82
Identities = 189/416 (45%), Positives = 249/416 (59%), Gaps = 38/416 (9%)
Query: 24 GSPGLPGR-------RSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLS 76
G P PG RS +RALEEA ++G L+LS R+L+ FP YDL+D TQADLS
Sbjct: 63 GPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP---GSGYDLTDTTQADLS 119
Query: 77 RNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL 136
RNRF E+P LE L+LYHNC++ + A+ NL LTYLN+SRN LS LP Y+ L
Sbjct: 120 RNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
Query: 137 PLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLST 196
PL+VL+VSNNKL ++P +IG L L +LD+S NE+Q LP ++ L SLR+LN+RRN L
Sbjct: 180 PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHV 239
Query: 197 LPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
LP+ELGDLPLV+LDFSCN+V+ IPV + +L HLQVI+LD+NPLQ PPAQ+CLKGK+HIFK
Sbjct: 240 LPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFK 299
Query: 257 YLSTEAGQRGS---------ALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDS 307
YL+ +A R +L PS+P + S ED +P + G DSG S D+
Sbjct: 300 YLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDS---MEDFYPNKNH--GPDSGIGS-DN 353
Query: 308 GSKRWSGNE-STDEFSELSFRISELAREPRGPRERKEDGS---ADGDPVQIDFIDSHVPG 363
G KR S E S D+ L ++SE RE + GS + D DF+D +
Sbjct: 354 GEKRLSTTEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNT-- 411
Query: 364 EDEERGTVEEQRPPEL----SPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERE 415
E V EQ + S G + + SR+ E G+E+R L +E +
Sbjct: 412 ---EDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEED 464
Score = 121 bits (304), Expect = 2e-27
Identities = 67/133 (50%), Positives = 89/133 (66%), Gaps = 4/133 (3%)
Query: 503 RPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAE 562
+P S RSS Q G + P +R R+ + +E++ + QLR LESRL+ LP+D+
Sbjct: 613 KPRSAFSRSSRQE-YGAADPGFTMR-RKMEHLREEREQIRQLRNNLESRLKVILPDDIGA 670
Query: 563 ALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLC 622
AL GV+LC LAN +RPRSV IHVPSPAVPKLS K R+NVE+FL+AC+K+GV + LC
Sbjct: 671 ALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLC 730
Query: 623 SPSDLLQGTARGL 635
P +L+ RGL
Sbjct: 731 LPHHILE--ERGL 741
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 116 bits (291), Expect = 6e-26
Identities = 78/188 (41%), Positives = 107/188 (56%), Gaps = 8/188 (4%)
Query: 54 LKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNL 113
L + P G + L+ + DLS N +P Q+ L L L HNCL L ALG L
Sbjct: 114 LTNLPAGLS---GLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
Query: 114 TALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQ 172
ALT+L ++ N+L LPP + L L+ L +S N L LPP+IG LGSL +L+++SN LQ
Sbjct: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
Query: 173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLDFSCNRVSRIPVSFCRLRHLQV 231
SLP+ L GL SLR L + N L+++P +L LPL+ RLD N++ +P L
Sbjct: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLDAPF 287
Query: 232 ILLDSNPL 239
+ L NPL
Sbjct: 288 VRLQGNPL 295
Score = 95.1 bits (235), Expect = 2e-19
Identities = 71/200 (35%), Positives = 104/200 (52%), Gaps = 28/200 (14%)
Query: 105 CLNPALGNLTA-------LTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIG 156
CL AL NL A L +L+LS N L LP + Q+ L L++S+N L LP +G
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
Query: 157 TLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNR 215
L +L L V+ N LQ+LP L LS+L+ L++ +N L TLP E+G L L+ L+ + NR
Sbjct: 169 ALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNR 228
Query: 216 VSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQ----------- 264
+ +P S LR L++++L SN L S PA + +L + L Q
Sbjct: 229 LQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLTRLDLRDNQLRDLPPELLDA 285
Query: 265 -----RGSALGDLAPSRPPS 279
+G+ LG+ +P P S
Sbjct: 286 PFVRLQGNPLGEASPDAPSS 305
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 116 bits (291), Expect = 6e-26
Identities = 78/188 (41%), Positives = 107/188 (56%), Gaps = 8/188 (4%)
Query: 54 LKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNL 113
L + P G + L+ + DLS N +P Q+ L L L HNCL L ALG L
Sbjct: 114 LTNLPAGLS---GLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGAL 170
Query: 114 TALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQ 172
ALT+L ++ N+L LPP + L L+ L +S N L LPP+IG LGSL +L+++SN LQ
Sbjct: 171 PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ 230
Query: 173 SLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLDFSCNRVSRIPVSFCRLRHLQV 231
SLP+ L GL SLR L + N L+++P +L LPL+ RLD N++ +P L
Sbjct: 231 SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPP---ELLDAPF 287
Query: 232 ILLDSNPL 239
+ L NPL
Sbjct: 288 VRLQGNPL 295
Score = 95.1 bits (235), Expect = 2e-19
Identities = 71/200 (35%), Positives = 104/200 (52%), Gaps = 28/200 (14%)
Query: 105 CLNPALGNLTA-------LTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIG 156
CL AL NL A L +L+LS N L LP + Q+ L L++S+N L LP +G
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168
Query: 157 TLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNR 215
L +L L V+ N LQ+LP L LS+L+ L++ +N L TLP E+G L L+ L+ + NR
Sbjct: 169 ALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNR 228
Query: 216 VSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQ----------- 264
+ +P S LR L++++L SN L S PA + +L + L Q
Sbjct: 229 LQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLTRLDLRDNQLRDLPPELLDA 285
Query: 265 -----RGSALGDLAPSRPPS 279
+G+ LG+ +P P S
Sbjct: 286 PFVRLQGNPLGEASPDAPSS 305
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 105 bits (261), Expect = 2e-22
Identities = 68/149 (45%), Positives = 91/149 (61%), Gaps = 5/149 (3%)
Query: 93 LEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGAL 151
L L L HNCL L ALG L ALT+L ++ N+L LPP + L L+ L +S N L L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 152 PPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLV-RLD 210
PP+IG LGSL +L+++SN LQSLP+ L GL SLR L + N L+++P +L LPL+ RLD
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLD 123
Query: 211 FSCNRVSRIPVSFCRLRHLQVILLDSNPL 239
N++ +P L + L NPL
Sbjct: 124 LRDNQLRDLPP---ELLDAPFVRLQGNPL 149
Score = 94.4 bits (233), Expect = 3e-19
Identities = 63/136 (46%), Positives = 83/136 (61%), Gaps = 1/136 (0%)
Query: 75 LSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYIC 134
LS N E+PEA L +L L++ HN L+ L PALG L+ L L+LS+N L LPP I
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
Query: 135 QL-PLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQ 193
L L L +++N+L +LP + L SLR L + SN L S+P++L L L L++R NQ
Sbjct: 69 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQ 128
Query: 194 LSTLPEELGDLPLVRL 209
L LP EL D P VRL
Sbjct: 129 LRDLPPELLDAPFVRL 144
Score = 79.7 bits (195), Expect = 8e-15
Identities = 55/159 (34%), Positives = 84/159 (52%), Gaps = 20/159 (12%)
Query: 138 LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
L L++S+N L LP +G L +L L V+ N LQ+LP L LS+L+ L++ +N L TL
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 198 PEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
P E+G L L+ L+ + NR+ +P S LR L++++L SN L S PA + +L +
Sbjct: 64 PPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADL---ARLPLLT 120
Query: 257 YLSTEAGQ----------------RGSALGDLAPSRPPS 279
L Q +G+ LG+ +P P S
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSS 159
Score = 72.4 bits (176), Expect = 1e-12
Identities = 48/135 (35%), Positives = 71/135 (52%), Gaps = 4/135 (2%)
Query: 45 GTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLR 104
G L LS+ L P L +T ++ NR +P A L +L+ L L N L
Sbjct: 5 GALLLSHNCLSELPEALGA---LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
Query: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQ 163
L P +G L +L LNL+ N+L LP + L LR+L++ +N L ++P D+ L L +
Sbjct: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
Query: 164 LDVSSNELQSLPSEL 178
LD+ N+L+ LP EL
Sbjct: 122 LDLRDNQLRDLPPEL 136
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/88 (34%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
L + + +L+ NR +P + L SL L L+ N L + L L LT L+L NQL
Sbjct: 70 LGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
Query: 127 SLLPPYICQLPLRVLIVSNNKLGALPPD 154
LPP + P + + N LG PD
Sbjct: 130 RDLPPELLDAPF--VRLQGNPLGEASPD 155
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 104 bits (259), Expect = 3e-22
Identities = 76/224 (33%), Positives = 114/224 (50%), Gaps = 6/224 (2%)
Query: 35 ERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVS-L 93
E L V +L L+ + +P G + S I ++ NR ++P L
Sbjct: 324 ESLLSSLVKLNSLTLARNCFQLYPVGGPSQF--STIYSLNMEHNRINKIPFGIFSRAKVL 381
Query: 94 EGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALP 152
L++ N L L G T++ LNL+ NQL+ +P + L L VLI+SNN L LP
Sbjct: 382 SKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLP 441
Query: 153 PDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDF 211
+G L LR+LD+ N+L+SLP+E+ L L+ L + NQL+TLP +G L L L
Sbjct: 442 HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGL 501
Query: 212 SCNRVSRIPVSFCRLRHLQVILLDSNP-LQSPPAQVCLKGKLHI 254
N ++ +P L +L+ + L+ NP L S P ++ L KL I
Sbjct: 502 GENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSI 545
Score = 89.7 bits (221), Expect = 8e-18
Identities = 66/222 (29%), Positives = 109/222 (49%), Gaps = 28/222 (12%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L+LS R + P +L+ +T+ L N+ +P LV+L L+L N L L
Sbjct: 105 LDLSKRSIHILPSSIK---ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSL 161
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP------------------------LRVLI 142
+L NL L L+L N+L +P + +L L +L
Sbjct: 162 PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221
Query: 143 VSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELG 202
+ NK+ LP +IG L +L LDV+ N+L+ LP E+ + + +L+++ N+L LP+ +G
Sbjct: 222 IRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIG 281
Query: 203 DL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP 243
+L L RL NR+S IP S + L+ + L++N + + P
Sbjct: 282 NLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLP 323
Score = 77.0 bits (188), Expect = 5e-14
Identities = 68/225 (30%), Positives = 101/225 (44%), Gaps = 31/225 (13%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L+L + +L+ P Y L +T L NR V + L L LS+ N ++ L
Sbjct: 174 LDLRHNKLREIPSVV---YRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQL 230
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+G L L L+++ NQL LP I + L + +N+L LP IG L SL +L
Sbjct: 231 PAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLG 290
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPE-------ELGDLPLVR---------- 208
+ N L ++P L S+L +LN+ N +STLPE +L L L R
Sbjct: 291 LRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGG 350
Query: 209 ---------LDFSCNRVSRIPVS-FCRLRHLQVILLDSNPLQSPP 243
L+ NR+++IP F R + L + + N L S P
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/85 (34%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 163 QLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPV 221
+LD+S + LPS + L+ L +L + N+L +LP E+G L L+ L S N ++ +P
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 222 SFCRLRHLQVILLDSNPLQSPPAQV 246
S L+ L+++ L N L+ P+ V
Sbjct: 164 SLDNLKKLRMLDLRHNKLREIPSVV 188
Score = 30.0 bits (66), Expect = 7.4
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 207 VRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV-CL 248
+RLD S + +P S L L + L SN LQS PA+V CL
Sbjct: 103 MRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCL 145
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 103 bits (256), Expect = 7e-22
Identities = 84/257 (32%), Positives = 119/257 (46%), Gaps = 34/257 (13%)
Query: 26 PGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPE 85
P LP + A LEE L++S RL H P + LS + D+ N+ P
Sbjct: 148 PALPAQLGALAHLEE------LDVSFNRLAHLPDSLSC---LSRLRTLDVDHNQLTAFPR 198
Query: 86 AACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVS 144
QLV+LE L + N LR L + L AL L LS +L LP C+L L L++
Sbjct: 199 QLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLD 258
Query: 145 NNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL 204
NN L ALP L L+ L++SSN + P+ L L+ L +L + RNQL+++P + L
Sbjct: 259 NNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGL 318
Query: 205 -PLVRLDFSCNRVSRIPVSFCRLRHLQVILLD-----------------------SNPLQ 240
L+ L NR+ +P S L L+ ++L NPL
Sbjct: 319 GRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLI 378
Query: 241 SPPAQVCLKGKLHIFKY 257
PP +VC+KG +I Y
Sbjct: 379 QPPYEVCMKGIPYIAAY 395
Score = 98.6 bits (244), Expect = 2e-20
Identities = 84/236 (35%), Positives = 111/236 (47%), Gaps = 28/236 (11%)
Query: 66 DLSDITQADLSRNRFPEVPEA-ACQLVSLEGLSLYHNCLRCLNPALGNLTA-LTYLNLSR 123
+L DI +L N EVPE L SL L L N L PA+ L LT L++S
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 124 NQLSLLPPYICQL--PLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGL 181
N+L+ L + LR L +S+N+L ALP +G L L +LDVS N L LP L L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL 180
Query: 182 SSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNR-----------------------VS 217
S LR L+V NQL+ P +L L L LD S NR +
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 218 RIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLA 273
+P FC L L+ ++LD+N LQ+ PAQ +L + S + +AL LA
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 102 bits (255), Expect = 9e-22
Identities = 72/194 (37%), Positives = 108/194 (55%), Gaps = 3/194 (1%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQ-LVSLEGLSLYHNCLRC 105
L L+ R L HFP + L + + + RN +PE Q L +L L L+ N +
Sbjct: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
Query: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQL 164
+ A+G+L L L+LS N L ++ P I +L LR L ++NN+L LPP++G L L+ L
Sbjct: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
Query: 165 DVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSF 223
D+S+N L +LP L SL+ L V RN+L +P L LP L L + NR++ +P+
Sbjct: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
Query: 224 CRLRHLQVILLDSN 237
R R LQ + +D+N
Sbjct: 200 GRSRELQYVYVDNN 213
Score = 72.0 bits (175), Expect = 2e-12
Identities = 56/154 (36%), Positives = 79/154 (51%), Gaps = 5/154 (3%)
Query: 97 SLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQ-LPLRV-LIVSNNKLGALPPD 154
+L+H L L L L L + RN L+ LP + Q LP V L + +N + +P
Sbjct: 26 NLHHFPLELLKDE--GLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEA 83
Query: 155 IGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSC 213
IG+L L+ LD+S N L+ + E+ L +LR L + NQL LP E+GDL L LD S
Sbjct: 84 IGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDIST 143
Query: 214 NRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVC 247
NR+ +P LQ + +D N L P +C
Sbjct: 144 NRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 99.4 bits (246), Expect = 1e-20
Identities = 65/210 (30%), Positives = 108/210 (51%), Gaps = 26/210 (12%)
Query: 33 SAERA-LEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLV 91
SA RA +E A TG L +R L FP + S++ DLS N+ +P
Sbjct: 4 SALRAHVETAQKTGVFQLKDRGLTEFPADLQKL--TSNLRTIDLSNNKIESLPPLL---- 57
Query: 92 SLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGA 150
+G T L L+L+ N+L++LP IC L L L ++NN L
Sbjct: 58 ------------------IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
Query: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLD 210
LP G L +L+ L +S N+L +LP +LC L L +++ +NQ+ ++P+ +G+L ++ L+
Sbjct: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELN 159
Query: 211 FSCNRVSRIPVSFCRLRHLQVILLDSNPLQ 240
+ N++S+I V L+++ L+ N L+
Sbjct: 160 LNQNQISQISVKISCCPRLKILRLEENCLE 189
Score = 77.0 bits (188), Expect = 5e-14
Identities = 45/121 (37%), Positives = 68/121 (56%), Gaps = 5/121 (4%)
Query: 138 LRVLIVSNNKLGALPPD-IGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLST 196
LR + +SNNK+ +LPP IG L+ L +++N+L LP E+C L L L++ N L
Sbjct: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
Query: 197 LPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIF 255
LP G L ++ L S N++ +P C LRHL V+ L N ++S P V G+L +
Sbjct: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV---GELQVI 156
Query: 256 K 256
+
Sbjct: 157 E 157
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/136 (29%), Positives = 72/136 (52%), Gaps = 3/136 (2%)
Query: 140 VLIVSNNKLGALPPDIGTLGS-LRQLDVSSNELQSLPSELCG-LSSLRDLNVRRNQLSTL 197
V + + L P D+ L S LR +D+S+N+++SLP L G + L+ L++ N+L+ L
Sbjct: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
Query: 198 PEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
P+E+ +L L L + N + +P +F +L L+ + L N L + P Q+C L +
Sbjct: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMD 137
Query: 257 YLSTEAGQRGSALGDL 272
+ ++G+L
Sbjct: 138 LSKNQIRSIPDSVGEL 153
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 99.0 bits (245), Expect = 1e-20
Identities = 95/364 (26%), Positives = 168/364 (46%), Gaps = 49/364 (13%)
Query: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
D+ DI++ +LS F A C+++ + L ++ N L L P +L +L
Sbjct: 32 DILDISKCELSEIPFGAF--ATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLA-------- 81
Query: 126 LSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
++VL + +N+L ALP D+G L +L+ L+V N+L LP + L+ L+
Sbjct: 82 -----------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQ 130
Query: 186 DLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
LNV+ N+L LP+ +G+L +R L+ S N + R+P +R L+++ LD++ + PP
Sbjct: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
Query: 245 QVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHS 304
+VC G I ++L E+G + P P++ L P D G+++ S
Sbjct: 191 EVCGAGTAAILQFLCKESGL--------------EYYP-PSQYLLPILEQD-GIENSRDS 234
Query: 305 VDSGSKRWSGNES--TDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVP 362
D + R+S E + FS+ R + E R E G + +
Sbjct: 235 PDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQRE----HTQLLQQSSS 290
Query: 363 GEDEERGTVEEQRPPELSPGAGDRERAPSSRR----EEPAGEERRRPDTLQLWQERERRQ 418
+DE TV+E++ L G + +R ++ R E+ E+ +Q + +RQ
Sbjct: 291 QKDEILQTVKEEQ-SRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQ 349
Query: 419 QQQS 422
++ S
Sbjct: 350 KKSS 353
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 99.0 bits (245), Expect = 1e-20
Identities = 95/364 (26%), Positives = 168/364 (46%), Gaps = 49/364 (13%)
Query: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
D+ DI++ +LS F A C+++ + L ++ N L L P +L +L
Sbjct: 32 DILDISKCELSEIPFGAF--ATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLA-------- 81
Query: 126 LSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
++VL + +N+L ALP D+G L +L+ L+V N+L LP + L+ L+
Sbjct: 82 -----------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQ 130
Query: 186 DLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
LNV+ N+L LP+ +G+L +R L+ S N + R+P +R L+++ LD++ + PP
Sbjct: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
Query: 245 QVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHS 304
+VC G I ++L E+G + P P++ L P D G+++ S
Sbjct: 191 EVCGAGTAAILQFLCKESGL--------------EYYP-PSQYLLPILEQD-GIENSRDS 234
Query: 305 VDSGSKRWSGNES--TDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVP 362
D + R+S E + FS+ R + E R E G + +
Sbjct: 235 PDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQRE----HTQLLQQSSS 290
Query: 363 GEDEERGTVEEQRPPELSPGAGDRERAPSSRR----EEPAGEERRRPDTLQLWQERERRQ 418
+DE TV+E++ L G + +R ++ R E+ E+ +Q + +RQ
Sbjct: 291 QKDEILQTVKEEQ-SRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQ 349
Query: 419 QQQS 422
++ S
Sbjct: 350 KKSS 353
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 99.0 bits (245), Expect = 1e-20
Identities = 95/364 (26%), Positives = 168/364 (46%), Gaps = 49/364 (13%)
Query: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
D+ DI++ +LS F A C+++ + L ++ N L L P +L +L
Sbjct: 32 DILDISKCELSEIPFGAF--ATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLA-------- 81
Query: 126 LSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
++VL + +N+L ALP D+G L +L+ L+V N+L LP + L+ L+
Sbjct: 82 -----------TIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQ 130
Query: 186 DLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
LNV+ N+L LP+ +G+L +R L+ S N + R+P +R L+++ LD++ + PP
Sbjct: 131 TLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPR 190
Query: 245 QVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHS 304
+VC G I ++L E+G + P P++ L P D G+++ S
Sbjct: 191 EVCGAGTAAILQFLCKESGL--------------EYYP-PSQYLLPILEQD-GIENSRDS 234
Query: 305 VDSGSKRWSGNES--TDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVP 362
D + R+S E + FS+ R + E R E G + +
Sbjct: 235 PDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQRE----HTQLLQQSSS 290
Query: 363 GEDEERGTVEEQRPPELSPGAGDRERAPSSRR----EEPAGEERRRPDTLQLWQERERRQ 418
+DE TV+E++ L G + +R ++ R E+ E+ +Q + +RQ
Sbjct: 291 QKDEILQTVKEEQ-SRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQ 349
Query: 419 QQQS 422
++ S
Sbjct: 350 KKSS 353
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/279 (28%), Positives = 129/279 (46%), Gaps = 52/279 (18%)
Query: 43 ATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNC 102
A L++ + +L P +L ++ + ++S N+ +PE L +L+ L L HN
Sbjct: 106 ALTVLDIHDNQLTSLPSAIR---ELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
Query: 103 LRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRV-LIVSNNKLGALPPDIGTLGSL 161
L C++ L+ L L+LS N L+ +P L V L +S+N+L +LP +I + L
Sbjct: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
Query: 162 RQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPE---------------------- 199
+ LD +SN L+++P EL G+ SL L +RRN+L LPE
Sbjct: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEA 282
Query: 200 -----------------ELGDLP--------LVRLDFSCNRVSRIPVSFCRLRHLQVILL 234
+L +P L RLD S N +S +P S L HL+ + L
Sbjct: 283 EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLAL 341
Query: 235 DSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLA 273
+ NPL++ ++ KG + KYL ++ G + + A
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESA 380
Score = 91.7 bits (226), Expect = 2e-18
Identities = 75/259 (28%), Positives = 119/259 (45%), Gaps = 35/259 (13%)
Query: 7 APLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPR------- 59
A AGG + TSVP + L+ A +G LNLS R L P+
Sbjct: 14 AGFKAGGRDCG--TSVP-----------QGLLKAARKSGQLNLSGRNLSEVPQCVWRINV 60
Query: 60 -------------GAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
R ++ +D+T+ +S N+ + + L +L L ++ N L L
Sbjct: 61 DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSL 120
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
A+ L L LN+S N+L +LP I L L+ L + +N+L + L +L LD
Sbjct: 121 PSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLD 180
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFC 224
+S+N L ++P+ LSSL LN+ N+L +LP E+ + L LD + N + IP
Sbjct: 181 LSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA 240
Query: 225 RLRHLQVILLDSNPLQSPP 243
+ L+++ L N L+ P
Sbjct: 241 GMESLELLYLRRNKLRFLP 259
Score = 73.9 bits (180), Expect = 4e-13
Identities = 50/136 (36%), Positives = 69/136 (50%), Gaps = 24/136 (17%)
Query: 135 QLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQL 194
Q L LI+SNNKL +L D+ L +L LD+ N+L SLPS + L +L+ LNV N+L
Sbjct: 81 QTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL 140
Query: 195 STLPEELGDL------------------------PLVRLDFSCNRVSRIPVSFCRLRHLQ 230
LPEE+ +L L LD S N ++ +P SF L L
Sbjct: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 231 VILLDSNPLQSPPAQV 246
+ L SN L+S PA++
Sbjct: 201 RLNLSSNELKSLPAEI 216
Score = 67.8 bits (164), Expect = 3e-11
Identities = 53/215 (24%), Positives = 104/215 (48%), Gaps = 25/215 (11%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L+ S+++ P + + +T + S+N+ E+P+ +L +
Sbjct: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEM------------- 450
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
++ ++LS N+LS + +C L L L + NN L +LP ++ +L L+ ++
Sbjct: 451 ---------VSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTIN 501
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTL-PEELGDLP-LVRLDFSCNRVSRIPVSF 223
+S N + LP L + +L + + NQ+ ++ P+++ + L LD N + +IP
Sbjct: 502 LSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 561
Query: 224 CRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYL 258
+L+ +LLD NP + P A + +KG I +YL
Sbjct: 562 GNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYL 596
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/210 (30%), Positives = 105/210 (50%), Gaps = 9/210 (4%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L+L ++K P + L + L N+F P C L +L+ L L N L+ +
Sbjct: 538 LDLGKNQIKKIPASISNMISLHVLI---LCCNKFETFPRELCTLENLQVLDLSENQLQKI 594
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP----LRVLIVSNNKLGALPPDIGTLGSLR 162
+ + NL + LN S NQ P +CQL L + + KL LP ++ + L+
Sbjct: 595 SSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLK 654
Query: 163 QLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPV 221
+LD+S+N ++ +P + L +L L+ NQ+S LP L L L +L+ S N ++ +P
Sbjct: 655 ELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPS 714
Query: 222 SFCRLRHLQVILLDSNPLQSPPAQVCLKGK 251
+ + L+ I D NPL PP ++C KGK
Sbjct: 715 AIYNIFSLKEINFDDNPLLRPPVEIC-KGK 743
Score = 80.9 bits (198), Expect = 4e-15
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 38/257 (14%)
Query: 14 EEAAATTSVPGSPGLPGRRSAERAL-----EEAVATGTLNLSNRRLKHFPRGAARSYDLS 68
E + T + L GR + +AL E V + +S K GA
Sbjct: 89 ETSTRTGTSQSLSSLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGA------- 141
Query: 69 DITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSRNQLS 127
D +L E P+ ++ ++ L L N ++ A G+L L L+L N LS
Sbjct: 142 DNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLS 201
Query: 128 LLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQ----------------------- 163
LP I L LR+L VS+N + +P +I LG++RQ
Sbjct: 202 SLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEI 261
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVS 222
L + N+L+ +P L L +LR LN+ NQL+T P+ L LP L+ LD + N +S +P
Sbjct: 262 LSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKE 321
Query: 223 FCRLRHLQVILLDSNPL 239
L++L+ +L+D N L
Sbjct: 322 IRELKNLETLLMDHNKL 338
Score = 79.7 bits (195), Expect = 8e-15
Identities = 58/205 (28%), Positives = 99/205 (48%), Gaps = 8/205 (3%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
+ LS ++ +FP G L + ++ N E+P L L L N L
Sbjct: 469 IELSYNKIMYFPLGLCA---LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIF 525
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+ +L L YL+L +NQ+ +P I + L VLI+ NK P ++ TL +L+ LD
Sbjct: 526 SEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLD 585
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS---CNRVSRIPV 221
+S N+LQ + S++C L ++ LN NQ P EL L L +L+ S +++R+P
Sbjct: 586 LSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPG 645
Query: 222 SFCRLRHLQVILLDSNPLQSPPAQV 246
+ L+ + + +N ++ P +
Sbjct: 646 ELSNMTQLKELDISNNAIREIPRNI 670
Score = 75.5 bits (184), Expect = 2e-13
Identities = 48/163 (29%), Positives = 85/163 (52%), Gaps = 2/163 (1%)
Query: 70 ITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLL 129
I + +LS N+ P C L SL LS+ N + + + L +L LS N+L +
Sbjct: 466 IIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIF 525
Query: 130 PPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLN 188
+ C L L+ L + N++ +P I + SL L + N+ ++ P ELC L +L+ L+
Sbjct: 526 SEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLD 585
Query: 189 VRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQ 230
+ NQL + ++ +L + +L+FS N+ P+ C+L+ L+
Sbjct: 586 LSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLE 628
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/215 (28%), Positives = 101/215 (46%), Gaps = 8/215 (3%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
LNL +L FP+ L + DL+ N +P+ +L +LE L + HN L L
Sbjct: 285 LNLEYNQLTTFPKALCF---LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFL 341
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+ L + L L+ N+L ++ I LR+LI+ N L +P I L L
Sbjct: 342 AVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLS 401
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFC 224
+S N+L LP + L++LR L+V RN + + + + L + L+FS N ++ +P+
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLS 259
+ + I L N + P +C L+ YLS
Sbjct: 462 NCQKIIKIELSYNKIMYFPLGLCALDSLY---YLS 493
Score = 70.9 bits (172), Expect = 4e-12
Identities = 52/182 (28%), Positives = 92/182 (50%), Gaps = 2/182 (1%)
Query: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
L ++ ++S N +P+ QL ++ L Y+N + L L L L+L +N+L
Sbjct: 210 LHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKL 269
Query: 127 SLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
+P + L LRVL + N+L P + L L LD++ N + SLP E+ L +L
Sbjct: 270 RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLE 329
Query: 186 DLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
L + N+L+ L E+ L ++ L + N++ I R L++++LD N L++ P
Sbjct: 330 TLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPE 389
Query: 245 QV 246
++
Sbjct: 390 KI 391
Score = 63.9 bits (154), Expect = 5e-10
Identities = 51/183 (27%), Positives = 87/183 (47%), Gaps = 2/183 (1%)
Query: 67 LSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQL 126
L++I + S N +VP + + L +N + L L +L YL+++ N +
Sbjct: 440 LNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYI 499
Query: 127 SLLPPYIC-QLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLR 185
S +P I L L +S NKL +L +L+ LD+ N+++ +P+ + + SL
Sbjct: 500 SEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLH 559
Query: 186 DLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
L + N+ T P EL L L LD S N++ +I C L+ +Q + SN P
Sbjct: 560 VLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPI 619
Query: 245 QVC 247
++C
Sbjct: 620 ELC 622
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 4/210 (1%)
Query: 75 LSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYI- 133
LS N+ E+P+ +L +L L + N + + + +L + L S N ++ +P I
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIK 461
Query: 134 -CQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRN 192
CQ +++ + S NK+ P + L SL L V+ N + +P ++ L L + N
Sbjct: 462 NCQKIIKIEL-SYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSEN 520
Query: 193 QLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGK 251
+L E L L LD N++ +IP S + L V++L N ++ P ++C
Sbjct: 521 KLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLEN 580
Query: 252 LHIFKYLSTEAGQRGSALGDLAPSRPPSFS 281
L + + + S + +L + +FS
Sbjct: 581 LQVLDLSENQLQKISSDICNLKGIQKLNFS 610
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 97.8 bits (242), Expect = 3e-20
Identities = 70/223 (31%), Positives = 105/223 (47%), Gaps = 45/223 (20%)
Query: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRN 124
+ LS ITQ LS N+ VP +L +LE L+ ++N + L + +L L +LNL N
Sbjct: 37 FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 96
Query: 125 QLSLLPPYICQLP--------------------------LRVLIVSNNKLGALPPDIGTL 158
+L+ LP LP LR L +S+N LPPDIG L
Sbjct: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 156
Query: 159 GSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSR 218
L+ L + N+L SLP E+ L+ L++L+++ N+L+ LP ELG+L L
Sbjct: 157 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLT----------- 205
Query: 219 IPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTE 261
QV ++NP +P A G H+F+Y+ +E
Sbjct: 206 --------GQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSE 240
Score = 64.7 bits (156), Expect = 3e-10
Identities = 49/141 (34%), Positives = 74/141 (52%), Gaps = 4/141 (2%)
Query: 110 LGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSS 168
L L+ +T L LS N+L+++PP I +L L VL NN++ LP I +L L+ L++
Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
Query: 169 NELQSLPSELCGLSSLRDLNVRRNQLS--TLPEELGDLPLVR-LDFSCNRVSRIPVSFCR 225
N L +LP L +L L++ N LS +LP L +R L S N +P +
Sbjct: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
Query: 226 LRHLQVILLDSNPLQSPPAQV 246
L LQ++ L N L S P ++
Sbjct: 156 LTKLQILSLRDNDLISLPKEI 176
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 97.1 bits (240), Expect = 5e-20
Identities = 79/227 (34%), Positives = 110/227 (48%), Gaps = 5/227 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L LS+ ++ P A L ++ D+SRN PE+PE+ +LE N L L
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVEL---DVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
L +L +L L+ L LP + L L L + N L +LP + L L QLD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFC 224
+ N+L+ LP L L +LR+L + RNQLS LP ELG+L LV LD S NR+ +P
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGD 271
L L +LL N L+ P + +L I K + A+GD
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 91.3 bits (225), Expect = 3e-18
Identities = 78/229 (34%), Positives = 109/229 (47%), Gaps = 14/229 (6%)
Query: 26 PGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPE 85
P +P +ALE A + S L P G + L+ + D+S P
Sbjct: 95 PEIPESIKFCKALEIA------DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG 148
Query: 86 AACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVS 144
LV+LE L N L+ L +L L L L+L N L +LP + LP LR L +
Sbjct: 149 NLANLVTLE---LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 145 NNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL 204
N+L ALPP++G L L LDVS N L+ LP+EL GL L DL + +N L LP+ +G L
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQL 265
Query: 205 -PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKL 252
L L NR+ + + +L ++L N L + P + GKL
Sbjct: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL---GKL 311
Score = 85.1 bits (209), Expect = 2e-16
Identities = 120/447 (26%), Positives = 174/447 (38%), Gaps = 69/447 (15%)
Query: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRC 105
TL L LK P A+ S+ L + Q DL N +P+ L +L L L N L
Sbjct: 155 TLELRENLLKSLP--ASLSF-LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRV-LIVSNNKLGALPPDIGTLGSLRQL 164
L P LGNL L L++S N+L LP + L L L++S N L LP IG L L L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 165 DVSSNEL-----------------------QSLPSELCGLSSLRDLNVRRNQLSTLPEEL 201
V N L +LP L L+ L +LNV RN L LP E+
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 202 GD-LPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP---AQVCLKG------- 250
G + L L NR++ +P L V+ + N LQS P + LK
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Query: 251 KLHIFKYLSTEAGQRGSALGD--LAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDSG 308
+ ++ + + + G + L P +PP + + S SV
Sbjct: 392 AQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPPSRV-SVIQF 450
Query: 309 SKRWSGNESTDEFSE----LSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVPGE 364
+ G+E +E + L R + E + + E ++ P Q D S +P E
Sbjct: 451 LEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPD-SGSPLPAE 509
Query: 365 DEER-----GTVEEQRP------------PELSPGAGDRERAPSSRREEPAGEERRRP-- 405
+E+R G E+ RP P G ++ A ++ EE A E+ + P
Sbjct: 510 EEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQEPTV 569
Query: 406 ----DTLQLWQERERRQQQQSGAWGAP 428
D L +RE + Q W P
Sbjct: 570 HFAEDALLPGDDREIEEGQPEAPWTLP 596
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 1/110 (0%)
Query: 138 LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
L L++ N+L LP L +LR+L +S NE+Q LP E+ L +L+V RN + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 198 PEELGDLPLVRL-DFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
PE + + + DFS N +SR+P F +LR L + L+ LQ+ P V
Sbjct: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDV 147
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/140 (32%), Positives = 68/140 (48%), Gaps = 2/140 (1%)
Query: 115 ALTYLNLSRNQLSLLP-PYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQS 173
+L L L NQL LP P+ L LR L +S+N++ LPP++ L +LDVS N++
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 174 LPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVI 232
+P + +L + N LS LP+ L L L + + +P L +L +
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
Query: 233 LLDSNPLQSPPAQVCLKGKL 252
L N L+S PA + KL
Sbjct: 157 ELRENLLKSLPASLSFLVKL 176
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 97.1 bits (240), Expect = 5e-20
Identities = 79/227 (34%), Positives = 110/227 (48%), Gaps = 5/227 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L LS+ ++ P A L ++ D+SRN PE+PE+ +LE N L L
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVEL---DVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
L +L +L L+ L LP + L L L + N L +LP + L L QLD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFC 224
+ N+L+ LP L L +LR+L + RNQLS LP ELG+L LV LD S NR+ +P
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGD 271
L L +LL N L+ P + +L I K + A+GD
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 91.3 bits (225), Expect = 3e-18
Identities = 78/229 (34%), Positives = 109/229 (47%), Gaps = 14/229 (6%)
Query: 26 PGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPE 85
P +P +ALE A + S L P G + L+ + D+S P
Sbjct: 95 PEIPESIKFCKALEIA------DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG 148
Query: 86 AACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVS 144
LV+LE L N L+ L +L L L L+L N L +LP + LP LR L +
Sbjct: 149 NLANLVTLE---LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 145 NNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL 204
N+L ALPP++G L L LDVS N L+ LP+EL GL L DL + +N L LP+ +G L
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQL 265
Query: 205 -PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKL 252
L L NR+ + + +L ++L N L + P + GKL
Sbjct: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSL---GKL 311
Score = 85.1 bits (209), Expect = 2e-16
Identities = 120/447 (26%), Positives = 174/447 (38%), Gaps = 69/447 (15%)
Query: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRC 105
TL L LK P A+ S+ L + Q DL N +P+ L +L L L N L
Sbjct: 155 TLELRENLLKSLP--ASLSF-LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRV-LIVSNNKLGALPPDIGTLGSLRQL 164
L P LGNL L L++S N+L LP + L L L++S N L LP IG L L L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 165 DVSSNEL-----------------------QSLPSELCGLSSLRDLNVRRNQLSTLPEEL 201
V N L +LP L L+ L +LNV RN L LP E+
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 202 GD-LPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP---AQVCLKG------- 250
G + L L NR++ +P L V+ + N LQS P + LK
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Query: 251 KLHIFKYLSTEAGQRGSALGD--LAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDSG 308
+ ++ + + + G + L P +PP + + S SV
Sbjct: 392 AQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPPSRV-SVIQF 450
Query: 309 SKRWSGNESTDEFSE----LSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVPGE 364
+ G+E +E + L R + E + + E ++ P Q D S +P E
Sbjct: 451 LEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPD-SGSPLPAE 509
Query: 365 DEER-----GTVEEQRP------------PELSPGAGDRERAPSSRREEPAGEERRRP-- 405
+E+R G E+ RP P G ++ A ++ EE A E+ + P
Sbjct: 510 EEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQEPTV 569
Query: 406 ----DTLQLWQERERRQQQQSGAWGAP 428
D L +RE + Q W P
Sbjct: 570 HFAEDALLPGDDREIEEGQPEAPWTLP 596
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 1/110 (0%)
Query: 138 LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
L L++ N+L LP L +LR+L +S NE+Q LP E+ L +L+V RN + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 198 PEELGDLPLVRL-DFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
PE + + + DFS N +SR+P F +LR L + L+ LQ+ P V
Sbjct: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDV 147
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/140 (32%), Positives = 68/140 (48%), Gaps = 2/140 (1%)
Query: 115 ALTYLNLSRNQLSLLP-PYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQS 173
+L L L NQL LP P+ L LR L +S+N++ LPP++ L +LDVS N++
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 174 LPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVI 232
+P + +L + N LS LP+ L L L + + +P L +L +
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
Query: 233 LLDSNPLQSPPAQVCLKGKL 252
L N L+S PA + KL
Sbjct: 157 ELRENLLKSLPASLSFLVKL 176
Score = 35.4 bits (80), Expect = 0.18
Identities = 59/237 (24%), Positives = 88/237 (37%), Gaps = 49/237 (20%)
Query: 357 IDSHVPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERER 416
+D GE+E+ E+++PP SP R+ +P+S G R + QER R
Sbjct: 1418 LDGETLGEEEQ----EDEQPPWASPSPTSRQ-SPASPPPLGGGAPVRTAKAERRHQERLR 1472
Query: 417 RQQQQSGA--------------------WGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNG 456
Q + A W A R SL + LRA + + S +
Sbjct: 1473 VQSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQM--VLSRSQEGRGTR 1530
Query: 457 SPKSSASQAGAAAGQGAPAPAP-------ASQEPLPIAGP-------ATAPAPRPLGSIQ 502
P ++A + A +P P S LP++G A P+ RP+ IQ
Sbjct: 1531 GPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAFAALPSSRPVYDIQ 1590
Query: 503 RPN-SFLFRSSSQSGS-GPSSPDSVL------RPRRYPQVPDEKDLMTQLRQVLESR 551
P+ + RS S S GP D + RP P++ L + R V R
Sbjct: 1591 SPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRPGR 1647
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 96.7 bits (239), Expect = 6e-20
Identities = 75/239 (31%), Positives = 111/239 (46%), Gaps = 51/239 (21%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L L LK P+ + L+ + + DL N F E+PE Q+ +L L + +N L+ L
Sbjct: 166 LELRENHLKTLPKSM---HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVL 222
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYIC----------------QLP--------LRVLI 142
++G L L YL++S+N++ + I QLP L L
Sbjct: 223 PGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Query: 143 VSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDL--------------- 187
V +N+L LP IG L L + D S NEL+SLPS + L SLR L
Sbjct: 283 VDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIG 342
Query: 188 --------NVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSN 237
++R N+L LPEE+G + +R L+ S NR+ +P SF +L+ L + L N
Sbjct: 343 SCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Score = 83.6 bits (205), Expect = 6e-16
Identities = 70/231 (30%), Positives = 109/231 (47%), Gaps = 9/231 (3%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPE--AACQLVSLEGLSLYHNCLR 104
L++ + L + P A +L ++ D+S+N E PE C+ +++ S+ N +
Sbjct: 74 LSIPDNDLSNLPTTIASLVNLKEL---DISKNGVQEFPENIKCCKCLTIIEASV--NPIS 128
Query: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQ 163
L L LT L L+ L LP +L LR+L + N L LP + L L +
Sbjct: 129 KLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLER 188
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVS 222
LD+ +NE LP L + +LR+L + N L LP +G L LV LD S NR+ + +
Sbjct: 189 LDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD 248
Query: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLA 273
L+ +LL SN LQ P + L KL K + + +G+L+
Sbjct: 249 ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 3/149 (2%)
Query: 111 GNLTALTYLNLSRNQLSLLPPYICQLP--LRVLIVSNNKLGALPPDIGTLGSLRQLDVSS 168
G ++ L+ S L +P + L L + N++ LP + +LR+L +
Sbjct: 19 GEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPD 78
Query: 169 NELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLR 227
N+L +LP+ + L +L++L++ +N + PE + L ++ S N +S++P F +L
Sbjct: 79 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 138
Query: 228 HLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
+L + L+ L+ PA KL I +
Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLVKLRILE 167
Score = 53.5 bits (127), Expect = 6e-07
Identities = 48/175 (27%), Positives = 77/175 (44%), Gaps = 27/175 (15%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L++S R++ + L D+ LS N ++P++ L L L + N L L
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLL---LSSNMLQQLPDSIGLLKKLTTLKVDDNQLTML 291
Query: 107 NPALGNLTALTYLNLSRNQLSLLPP----------------YICQLP--------LRVLI 142
+GNL+ L + S N+L LP ++ +LP + V+
Sbjct: 292 PNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMS 351
Query: 143 VSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
+ +NKL LP +IG + LR L++S N L++LP L L L + NQ L
Sbjct: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 95.1 bits (235), Expect = 2e-19
Identities = 74/227 (32%), Positives = 112/227 (49%), Gaps = 5/227 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L LS+ ++ P A L ++ D+SRN PE+PE+ +L+ N L L
Sbjct: 64 LGLSDNEIQRLPPEIANFMQLVEL---DVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+ L LT L+++ L LP I L L L + N L LP + L L +LD
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFC 224
+ +NE+ +LP + L L+DL + NQLS LP+E+G+L L+ LD S NR+ R+P
Sbjct: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGD 271
L L +++ N L++ P + KL I K Q A+G+
Sbjct: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGE 287
Score = 92.0 bits (227), Expect = 2e-18
Identities = 77/238 (32%), Positives = 117/238 (49%), Gaps = 14/238 (5%)
Query: 26 PGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPE 85
P +P S +AL+ A +G N R + FP +L ++T ++ +PE
Sbjct: 95 PEIPESISFCKALQVADFSG--NPLTRLPESFP-------ELQNLTCLSVNDISLQSLPE 145
Query: 86 AACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYI-CQLPLRVLIVS 144
L +L L L N L L +L L L L+L N++ LP I L L+ L +
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLD 205
Query: 145 NNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL 204
N+L LP +IG L +L LDVS N L+ LP E+ GL+SL DL + +N L T+P+ +G L
Sbjct: 206 GNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL 265
Query: 205 -PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTE 261
L L NR++++P + L ++L N L + P + GKL L+ +
Sbjct: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSI---GKLKKLSNLNAD 320
Score = 88.2 bits (217), Expect = 2e-17
Identities = 63/175 (36%), Positives = 88/175 (50%), Gaps = 4/175 (2%)
Query: 75 LSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYI- 133
L N+ E+PE QLV L L L N ++ L P + N L L++SRN++ +P I
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 134 -CQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRN 192
C+ L+V S N L LP L +L L V+ LQSLP + L +L L +R N
Sbjct: 103 FCK-ALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELREN 161
Query: 193 QLSTLPEELGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
L+ LP+ L L L LD N + +P S L HL+ + LD N L P ++
Sbjct: 162 LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Score = 86.7 bits (213), Expect = 7e-17
Identities = 70/218 (32%), Positives = 105/218 (48%), Gaps = 11/218 (5%)
Query: 28 LPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAA 87
LP + R LEE L+L N + + P L D+ L N+ E+P+
Sbjct: 166 LPDSLTQLRRLEE------LDLGNNEIYNLPESIGALLHLKDLW---LDGNQLSELPQEI 216
Query: 88 CQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNN 146
L +L L + N L L + LT+LT L +S+N L +P I +L L +L V N
Sbjct: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276
Query: 147 KLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGD-LP 205
+L LP +G SL +L ++ N+L +LP + L L +LN RN+L +LP+E+G
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
Query: 206 LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP 243
L NR++RIP + L V+ + N L P
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Score = 70.1 bits (170), Expect = 6e-12
Identities = 58/170 (34%), Positives = 83/170 (48%), Gaps = 4/170 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L++S RL+ P + L+D+ +S+N +P+ +L L L + N L L
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLV---ISQNLLETIPDGIGKLKKLSILKVDQNRLTQL 281
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
A+G +LT L L+ NQL LP I +L L L NKL +LP +IG SL
Sbjct: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNR 215
V N L +P+E+ + L L+V N+L LP L L L L S N+
Sbjct: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ 391
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/157 (34%), Positives = 78/157 (49%), Gaps = 2/157 (1%)
Query: 92 SLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQ-LPLRVLIVSNNKLGA 150
SLE L L N LR L L L L LS N++ LPP I + L L VS N++
Sbjct: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96
Query: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRL 209
+P I +L+ D S N L LP L +L L+V L +LPE +G+L L L
Sbjct: 97 IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL 156
Query: 210 DFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
+ N ++ +P S +LR L+ + L +N + + P +
Sbjct: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 94.0 bits (232), Expect = 4e-19
Identities = 64/210 (30%), Positives = 109/210 (51%), Gaps = 5/210 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L L +LK P+ R L+ + + DL N F EVPE QL L+ + N L +
Sbjct: 166 LELRENQLKMLPKTMNR---LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+G+L LTYL++S+N + ++ I L+ L++S+N L LP IG+L ++ L
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFC 224
+ N+L LP + GL S+ +L+ N++ LP +G L +R N + ++P
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHI 254
+++ V+ L SN L++ P ++ KL +
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Score = 74.3 bits (181), Expect = 3e-13
Identities = 62/204 (30%), Positives = 99/204 (48%), Gaps = 9/204 (4%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAA--CQLVSLEGLSLYHNCLR 104
L+L + L P A +L ++ + D+S+N E PE C+++++ S+ N +
Sbjct: 74 LSLPDNDLTTLPASIA---NLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV--NPIS 128
Query: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQ 163
L L LT L L+ L LP +L L++L + N+L LP + L L +
Sbjct: 129 KLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVS 222
LD+ SNE +P L LS L++ + N+L+ +P +G L L LD S N + +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
Query: 223 FCRLRHLQVILLDSNPLQSPPAQV 246
+LQ +LL SN LQ P +
Sbjct: 249 ISTCENLQDLLLSSNSLQQLPETI 272
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/153 (30%), Positives = 81/153 (52%), Gaps = 4/153 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L++S ++ G + +L D+ LS N ++PE L ++ L + N L L
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLL---LSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
++G L ++ L+ S N++ LP I QL LR +N L LPP+IG+ ++ L
Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLF 351
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLP 198
+ SN+L++LP E+ + L+ +N+ N+L LP
Sbjct: 352 LHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 71.6 bits (174), Expect = 2e-12
Identities = 68/226 (30%), Positives = 105/226 (46%), Gaps = 11/226 (4%)
Query: 36 RALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEG 95
R EE V T L+ S+ L+ P+ + + L N+ E+P+ SL
Sbjct: 18 RGEEETVTT--LDYSHCSLEQVPKEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHK 73
Query: 96 LSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYI--CQLPLRVLIVSNNKLGALPP 153
LSL N L L ++ NL L L++S+N + P I C++ L ++ S N + LP
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD 132
Query: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
L +L QL ++ L+ LP+ L+ L+ L +R NQL LP+ + L L RLD
Sbjct: 133 GFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 213 CNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYL 258
N + +P +L L+ +D+N L P + G L YL
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI---GSLKQLTYL 235
Score = 63.5 bits (153), Expect = 6e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 8/165 (4%)
Query: 38 LEEAVAT----GTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSL 93
+EE ++T L LS+ L+ P L +IT + N+ +P++ L+S+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIG---SLKNITTLKIDENQLMYLPDSIGGLISV 301
Query: 94 EGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALP 152
E L N + L ++G LT L N L LPP I + VL + +NKL LP
Sbjct: 302 EELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 153 PDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
++G + L+ +++S N L++LP L L + + NQ L
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/154 (27%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 104 RCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQ 163
RCL +T L Y + S Q+ + + L L + N++ LP + SL +
Sbjct: 15 RCLRGEEETVTTLDYSHCSLEQVPK-EIFTFEKTLEELYLDANQIEELPKQLFNCQSLHK 73
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRL-DFSCNRVSRIPVS 222
L + N+L +LP+ + L +LR+L+V +N + PE + + ++ + + S N +S++P
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG 133
Query: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
F +L +L + L+ L+ PA KL I +
Sbjct: 134 FSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 94.0 bits (232), Expect = 4e-19
Identities = 64/210 (30%), Positives = 109/210 (51%), Gaps = 5/210 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L L +LK P+ R L+ + + DL N F EVPE QL L+ + N L +
Sbjct: 166 LELRENQLKMLPKTMNR---LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+G+L LTYL++S+N + ++ I L+ L++S+N L LP IG+L ++ L
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFC 224
+ N+L LP + GL S+ +L+ N++ LP +G L +R N + ++P
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHI 254
+++ V+ L SN L++ P ++ KL +
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Score = 74.3 bits (181), Expect = 3e-13
Identities = 62/204 (30%), Positives = 99/204 (48%), Gaps = 9/204 (4%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAA--CQLVSLEGLSLYHNCLR 104
L+L + L P A +L ++ + D+S+N E PE C+++++ S+ N +
Sbjct: 74 LSLPDNDLTTLPASIA---NLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV--NPIS 128
Query: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQ 163
L L LT L L+ L LP +L L++L + N+L LP + L L +
Sbjct: 129 KLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVS 222
LD+ SNE +P L LS L++ + N+L+ +P +G L L LD S N + +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
Query: 223 FCRLRHLQVILLDSNPLQSPPAQV 246
+LQ +LL SN LQ P +
Sbjct: 249 ISTCENLQDLLLSSNSLQQLPETI 272
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/153 (30%), Positives = 81/153 (52%), Gaps = 4/153 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L++S ++ G + +L D+ LS N ++PE L ++ L + N L L
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLL---LSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLD 165
++G L ++ L+ S N++ LP I QL LR +N L LPP+IG+ ++ L
Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLF 351
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLP 198
+ SN+L++LP E+ + L+ +N+ N+L LP
Sbjct: 352 LHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 71.6 bits (174), Expect = 2e-12
Identities = 68/226 (30%), Positives = 105/226 (46%), Gaps = 11/226 (4%)
Query: 36 RALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEG 95
R EE V T L+ S+ L+ P+ + + L N+ E+P+ SL
Sbjct: 18 RGEEETVTT--LDYSHCSLEQVPKEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHK 73
Query: 96 LSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYI--CQLPLRVLIVSNNKLGALPP 153
LSL N L L ++ NL L L++S+N + P I C++ L ++ S N + LP
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD 132
Query: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
L +L QL ++ L+ LP+ L+ L+ L +R NQL LP+ + L L RLD
Sbjct: 133 GFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
Query: 213 CNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYL 258
N + +P +L L+ +D+N L P + G L YL
Sbjct: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFI---GSLKQLTYL 235
Score = 63.5 bits (153), Expect = 6e-10
Identities = 48/165 (29%), Positives = 78/165 (47%), Gaps = 8/165 (4%)
Query: 38 LEEAVAT----GTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSL 93
+EE ++T L LS+ L+ P L +IT + N+ +P++ L+S+
Sbjct: 245 VEEGISTCENLQDLLLSSNSLQQLPETIG---SLKNITTLKIDENQLMYLPDSIGGLISV 301
Query: 94 EGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALP 152
E L N + L ++G LT L N L LPP I + VL + +NKL LP
Sbjct: 302 EELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 153 PDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
++G + L+ +++S N L++LP L L + + NQ L
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/154 (27%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 104 RCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQ 163
RCL +T L Y + S Q+ + + L L + N++ LP + SL +
Sbjct: 15 RCLRGEEETVTTLDYSHCSLEQVPK-EIFTFEKTLEELYLDANQIEELPKQLFNCQSLHK 73
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRL-DFSCNRVSRIPVS 222
L + N+L +LP+ + L +LR+L+V +N + PE + + ++ + + S N +S++P
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG 133
Query: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
F +L +L + L+ L+ PA KL I +
Sbjct: 134 FSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 92.0 bits (227), Expect = 2e-18
Identities = 65/217 (29%), Positives = 104/217 (47%), Gaps = 5/217 (2%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
L L+ LK P+ L +I L RN+F P+ C L +LE + L N + +
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIY---LKRNQFEVFPQELCVLYTLEIIDLDENKIGAI 203
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+G+LT L ++ N L +LP +CQ L VL +S+N L ++P L + ++
Sbjct: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVSFC 224
+S N L+ +P +C +SL L + L L L +R LD S N + P+ C
Sbjct: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
Query: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTE 261
L++L+V+ LD N + P+++ KL I E
Sbjct: 324 ALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNE 360
Score = 91.7 bits (226), Expect = 2e-18
Identities = 63/206 (30%), Positives = 97/206 (47%), Gaps = 25/206 (12%)
Query: 93 LEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGAL 151
LE L L N L+CL + N T L + L RNQ + P +C L L ++ + NK+GA+
Sbjct: 144 LELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAI 203
Query: 152 PPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLD 210
P +IG L L++ ++SN L LP+ LC S L L++ N L ++P+ +L + +
Sbjct: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 211 FSCNRVSRIPVSFCR-----------------------LRHLQVILLDSNPLQSPPAQVC 247
S NR+ ++P CR L +L+ + L N L P Q+C
Sbjct: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
Query: 248 LKGKLHIFKYLSTEAGQRGSALGDLA 273
L + + GQ S LG L+
Sbjct: 324 ALKNLEVLGLDDNKIGQLPSELGSLS 349
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/261 (29%), Positives = 114/261 (43%), Gaps = 54/261 (20%)
Query: 27 GLPGRR--SAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVP 84
GL G R R + + L L N L H RG+ R L ++ DLS+N P
Sbjct: 263 GLSGNRLEKVPRLICRWTSLHLLYLGNTGL-HRLRGSFRC--LVNLRFLDLSQNHLHHCP 319
Query: 85 EAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ------------------- 125
C L +LE L L N + L LG+L+ L L L+ N+
Sbjct: 320 LQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYI 379
Query: 126 -------LSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSE 177
L+ +P +I +L L+ L + NN L LP +G++ +L LD N L+ LP
Sbjct: 380 GQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDA 439
Query: 178 LCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSN 237
+C +L++L + N L+ LPE L L +L+V+ L N
Sbjct: 440 ICQAQALKELRLEDNLLTHLPENLDSLV----------------------NLKVLTLMDN 477
Query: 238 PLQSPPAQVCLKGKLHIFKYL 258
P++ PP +VC +G I+KYL
Sbjct: 478 PMEEPPKEVCAEGNEAIWKYL 498
Score = 83.6 bits (205), Expect = 6e-16
Identities = 75/284 (26%), Positives = 121/284 (42%), Gaps = 56/284 (19%)
Query: 21 SVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRF 80
SV SP + R + + T ++ SN+ L P + +++ + L N+
Sbjct: 7 SVEHSPKIHQRNDPQHVNDR---TFFIDASNQSLTAIP---LEIFTFTELEEVHLENNQI 60
Query: 81 PEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRN---------------- 124
E+P+ +L ++ L L N LR L PALG L++L L+LS N
Sbjct: 61 EEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHAL 120
Query: 125 -QLSLLPPYICQLP---------LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSL 174
+L L + ++P L +L ++ N L LP +I LR++ + N+ +
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
Query: 175 PSELCGLSSLRDLNVRRNQLSTLPEELGDL------------------------PLVRLD 210
P ELC L +L +++ N++ +PEE+G L L LD
Sbjct: 181 PQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240
Query: 211 FSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHI 254
S N + IP SF LR + I L N L+ P +C LH+
Sbjct: 241 LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL 284
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 90.5 bits (223), Expect = 5e-18
Identities = 64/199 (32%), Positives = 98/199 (49%), Gaps = 22/199 (11%)
Query: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
+L ++ + N+ E+P L L+ L+L N L L G+L AL L+L+ N
Sbjct: 8 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 67
Query: 126 LS---LLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLS 182
LS L + LR L +S+N LPPDIG L L+ L + N+L SLP E+ L+
Sbjct: 68 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 127
Query: 183 SLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSP 242
L++L+++ N+L+ LP ELG+L L QV ++NP +P
Sbjct: 128 QLKELHIQGNRLTVLPPELGNLDLT-------------------GQKQVFKAENNPWVTP 168
Query: 243 PAQVCLKGKLHIFKYLSTE 261
A G H+F+Y+ +E
Sbjct: 169 IADQFQLGVSHVFEYIRSE 187
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/125 (29%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Query: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-L 209
+PP+I L +L L+ +N+++ LP+++ L L+ LN+ N+L+TLP G LP + L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 210 DFSCNRVSR--IPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGS 267
D + N +S +P +F L L+ + L N + P + KL I +
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 268 ALGDL 272
+G+L
Sbjct: 122 EIGEL 126
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 90.1 bits (222), Expect = 6e-18
Identities = 63/212 (29%), Positives = 106/212 (50%), Gaps = 6/212 (2%)
Query: 36 RALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEG 95
+AL T + L+ +++ P + L + L N P+V C L L
Sbjct: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLV---LQNNLIPKVCPELCNLTQLTT 64
Query: 96 LSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQ--LPLRVLIVSNNKLGALPP 153
L+L +N L + + LT+L L+LS N++ P C L +L ++NN L LP
Sbjct: 65 LNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQ 124
Query: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
++ L SL + ++ N+L S+P ELC L +L +L + NQL +PEE+ L L +L +
Sbjct: 125 EVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLA 184
Query: 213 CNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
N + +P C L+ L+++ + N +Q P+
Sbjct: 185 RNNIGVLPEELCDLKKLRILDIAGNIIQIFPS 216
Score = 72.8 bits (177), Expect = 1e-12
Identities = 55/163 (33%), Positives = 82/163 (50%), Gaps = 5/163 (3%)
Query: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQ-LVSLEGLSLYHNCLR 104
TLNL N L+ P L+ + LS NR AC L +L L+L +N L
Sbjct: 64 TLNLGNNLLEEVPEEMKY---LTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLT 120
Query: 105 CLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSN-NKLGALPPDIGTLGSLRQ 163
L + L +LTY++++ NQL+ +P +C L V + N N+L +P +I L L++
Sbjct: 121 QLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQK 180
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPL 206
L ++ N + LP ELC L LR L++ N + P DL L
Sbjct: 181 LLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKL 223
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/147 (25%), Positives = 79/147 (53%), Gaps = 3/147 (2%)
Query: 104 RCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLR 162
R L AL + L+ +++ +P + +LP L+ L++ NN + + P++ L L
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
Query: 163 QLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGD--LPLVRLDFSCNRVSRIP 220
L++ +N L+ +P E+ L+SL++L++ N++ D L+ L+ + N ++++P
Sbjct: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
Query: 221 VSFCRLRHLQVILLDSNPLQSPPAQVC 247
RL+ L + ++ N L S P ++C
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIPRELC 150
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 5/126 (3%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
LNL+N L P+ +R L +T ++ N+ +P C L +L L L +N L C+
Sbjct: 112 LNLNNNHLTQLPQEVSR---LKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICI 168
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
+ L L L L+RN + +LP +C L LR+L ++ N + P L LR+
Sbjct: 169 PEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFY 227
Query: 166 VSSNEL 171
N L
Sbjct: 228 CEGNPL 233
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 87.8 bits (216), Expect = 3e-17
Identities = 62/216 (28%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 37 ALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAAC--QLVSLE 94
+L++ + L L N L+ P + LS++ + DL N + E L L
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
Query: 95 GLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPP 153
L L+HN + + P++ ++ L L S N+L LP + L LR L VS N + +P
Sbjct: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
Query: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
+IG L +L+ L ++ N++ LP +L LR LN+ +N +++LPE++G L L +L+
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 213 CNRVSRIPVSF--CRLRHLQVILLDSNPLQSPPAQV 246
N + R+P CR+ ++++ + + P +V
Sbjct: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
Score = 43.9 bits (102), Expect = 5e-04
Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 63/248 (25%)
Query: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYH--------------NCLRCLN--- 107
+DL+D+ L ++P Q+ +L+ L L H + LRCL+
Sbjct: 487 FDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKF 546
Query: 108 ------PA-------LGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPD 154
PA L L + LN N++ L L++L V +N L +P +
Sbjct: 547 TDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSN 605
Query: 155 I---------------GT----LGSLR------QLDVSSNELQSLPSELCGLSSLRDLNV 189
I GT L SL+ +L++ + EL+ +P + LS+L++L++
Sbjct: 606 ITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDL 665
Query: 190 RRNQLSTLPEELGDLPLVRLDFSC-----NRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
+ N + T+ E + L RL +C N++ IP S +++L+ + +N L+S P
Sbjct: 666 KSNNIRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPV 723
Query: 245 QVCLKGKL 252
V KL
Sbjct: 724 AVFSLQKL 731
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 87.8 bits (216), Expect = 3e-17
Identities = 62/216 (28%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 37 ALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAAC--QLVSLE 94
+L++ + L L N L+ P + LS++ + DL N + E L L
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
Query: 95 GLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPP 153
L L+HN + + P++ ++ L L S N+L LP + L LR L VS N + +P
Sbjct: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
Query: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212
+IG L +L+ L ++ N++ LP +L LR LN+ +N +++LPE++G L L +L+
Sbjct: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
Query: 213 CNRVSRIPVSF--CRLRHLQVILLDSNPLQSPPAQV 246
N + R+P CR+ ++++ + + P +V
Sbjct: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
Score = 43.9 bits (102), Expect = 5e-04
Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 63/248 (25%)
Query: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYH--------------NCLRCLN--- 107
+DL+D+ L ++P Q+ +L+ L L H + LRCL+
Sbjct: 487 FDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKF 546
Query: 108 ------PA-------LGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPD 154
PA L L + LN N++ L L++L V +N L +P +
Sbjct: 547 TDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSN 605
Query: 155 I---------------GT----LGSLR------QLDVSSNELQSLPSELCGLSSLRDLNV 189
I GT L SL+ +L++ + EL+ +P + LS+L++L++
Sbjct: 606 ITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDL 665
Query: 190 RRNQLSTLPEELGDLPLVRLDFSC-----NRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
+ N + T+ E + L RL +C N++ IP S +++L+ + +N L+S P
Sbjct: 666 KSNNIRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPV 723
Query: 245 QVCLKGKL 252
V KL
Sbjct: 724 AVFSLQKL 731
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 87.4 bits (215), Expect = 4e-17
Identities = 64/194 (32%), Positives = 107/194 (55%), Gaps = 6/194 (3%)
Query: 65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL-NPALGNLTALTYLNLSR 123
+ L D++ DLS N+ E P ++ L+L HN + + N NLT L YL+LS
Sbjct: 101 FKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSE 160
Query: 124 NQLSLLPPYICQLP-LRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNEL--QSLPSELC 179
N+L LPP + +L L+ L+++ N L A + + +L+ L + S + +LP+ L
Sbjct: 161 NRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
Query: 180 GLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNP 238
GLS+L D+++ N L+ +PE L LP L RL+ S N+++ + + + H++ + L N
Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 239 LQSPPAQVCLKGKL 252
L S P+ +C KL
Sbjct: 281 LTSLPSAICKLSKL 294
Score = 83.6 bits (205), Expect = 6e-16
Identities = 64/180 (35%), Positives = 90/180 (50%), Gaps = 8/180 (4%)
Query: 27 GLPGRRSAERALEEAVATGTLNL--SNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVP 84
G P + R L A TL+L + R + P LS++ DLS N VP
Sbjct: 183 GNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE---GLSNLADVDLSCNDLTRVP 239
Query: 85 EAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIV 143
E L SL L+L N + L+ + + LNLSRNQL+ LP IC+L L+ L +
Sbjct: 240 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYL 299
Query: 144 SNNKL--GALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEEL 201
++NKL LP IG L +L + ++N L+ +P LC LR L + +N L TLPE +
Sbjct: 300 NSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAI 359
Score = 81.6 bits (200), Expect = 2e-15
Identities = 62/173 (35%), Positives = 85/173 (49%), Gaps = 7/173 (4%)
Query: 74 DLSRNRFPE--VPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPP 131
DLS N F PE + SL L L L L L L L +L++S N L+ L
Sbjct: 14 DLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHG 73
Query: 132 YICQLP-LRVLIVSNNKL--GALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLN 188
+ LP LR ++ N L +P DI L L LD+S N+L P EL ++ LN
Sbjct: 74 ELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLN 133
Query: 189 VRRNQLSTLPEEL--GDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPL 239
+ N + T+P +L L+ LD S NR+ +P RL HLQ ++L+ NPL
Sbjct: 134 LSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL 186
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 147 KLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPL 206
K G P ++ + SLR L ++ L LP EL L L L+V N L+TL EL LP
Sbjct: 21 KGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPS 80
Query: 207 VR---LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQV 246
+R + + S +P +L L V+ L N L P ++
Sbjct: 81 LRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPREL 123
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 86.3 bits (212), Expect = 9e-17
Identities = 59/175 (33%), Positives = 88/175 (50%), Gaps = 2/175 (1%)
Query: 82 EVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRV 140
++P+ L ++ L+L HN LR L P +G LT + LNL N+L LP + L L+V
Sbjct: 62 DIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKV 121
Query: 141 LIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEE 200
L V+ N L +P ++ L L +S N L LP+ LS LR LN+ N + +P
Sbjct: 122 LFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMC 181
Query: 201 LGDL-PLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHI 254
+ L L+ L NR+ I S L LQ+ + + N + S P +CL L +
Sbjct: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLEL 236
Score = 78.2 bits (191), Expect = 2e-14
Identities = 70/216 (32%), Positives = 99/216 (45%), Gaps = 23/216 (10%)
Query: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
LNL RLK PR + L + ++ N EVP LE LSL HNCL L
Sbjct: 99 LNLCGNRLKSLPREVSL---LQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQL 155
Query: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLI---VSNNKLGALPPDIGTLGSLRQ 163
+L+ L LNLS N + +P +C L+ LI V +N+L + I L SL+
Sbjct: 156 PACFADLSRLRKLNLSNNFFAHIP--MCVFSLKELIFLHVGSNRLENIAESIQHLASLQI 213
Query: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFSCNRVSRIPVS 222
N + S P LC ++SL LN+ N + TLP EL L LVR+ ++ P+
Sbjct: 214 FIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWN-------PMD 266
Query: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYL 258
+ + + NPL P ++ G +F YL
Sbjct: 267 -------KGLHISHNPLSKPLPELVEGGLEMLFGYL 295
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/112 (31%), Positives = 56/112 (50%), Gaps = 1/112 (0%)
Query: 171 LQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHL 229
+ +P L GLS ++ LN+ NQL LP E+G L +V L+ NR+ +P L+ L
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
Query: 230 QVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFS 281
+V+ ++ N L PA++ L KL + Q + DL+ R + S
Sbjct: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLS 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,613,450
Number of Sequences: 37866
Number of extensions: 1761915
Number of successful extensions: 18622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 217
Number of HSP's successfully gapped in prelim test: 904
Number of HSP's that attempted gapping in prelim test: 13838
Number of HSP's gapped (non-prelim): 4201
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.