Search of human proteins with 30089960

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
         (1638 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...  3284   0.0  
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...  3154   0.0  
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]        1939   0.0  
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...  1333   0.0  
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s...   521   e-147
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s...   521   e-147
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa...   516   e-146
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s...   478   e-134
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   452   e-127
gi|41872583 Rho-associated, coiled-coil containing protein kinas...   451   e-126
gi|32698688 citron [Homo sapiens]                                     392   e-108
gi|6005814 serine/threonine kinase 38 [Homo sapiens]                  308   2e-83
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   212   2e-54
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   209   2e-53
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   209   2e-53
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   206   1e-52
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   206   1e-52
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   206   1e-52
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   206   2e-52
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   206   2e-52
gi|150170729 microtubule associated serine/threonine kinase 3 [H...   206   2e-52
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   205   3e-52
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   204   6e-52
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   204   6e-52
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   204   6e-52
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   204   6e-52
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   204   6e-52
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   204   7e-52
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   203   1e-51
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   202   2e-51

>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
            sapiens]
          Length = 1638

 Score = 3284 bits (8514), Expect = 0.0
 Identities = 1638/1638 (100%), Positives = 1638/1638 (100%)

Query: 1    MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
            MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA
Sbjct: 1    MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60

Query: 61   KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
            KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA
Sbjct: 61   KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120

Query: 121  CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
            CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
Sbjct: 121  CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180

Query: 181  YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
            YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT
Sbjct: 181  YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240

Query: 241  PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
            PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
Sbjct: 241  PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300

Query: 301  FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
            FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
Sbjct: 301  FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360

Query: 361  EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
            EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA
Sbjct: 361  EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420

Query: 421  GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
            GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP
Sbjct: 421  GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480

Query: 481  LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
            LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
Sbjct: 481  LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540

Query: 541  QQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIE 600
            QQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIE
Sbjct: 541  QQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIE 600

Query: 601  HQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKD 660
            HQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKD
Sbjct: 601  HQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKD 660

Query: 661  KLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLE 720
            KLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLE
Sbjct: 661  KLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLE 720

Query: 721  EEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRA 780
            EEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRA
Sbjct: 721  EEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRA 780

Query: 781  TDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 840
            TDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN
Sbjct: 781  TDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 840

Query: 841  LELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPT 900
            LELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPT
Sbjct: 841  LELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPT 900

Query: 901  LRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITC 960
            LRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITC
Sbjct: 901  LRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITC 960

Query: 961  VNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLF 1020
            VNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLF
Sbjct: 961  VNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLF 1020

Query: 1021 LYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASN 1080
            LYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASN
Sbjct: 1021 LYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASN 1080

Query: 1081 NKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAA 1140
            NKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAA
Sbjct: 1081 NKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAA 1140

Query: 1141 IIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFP 1200
            IIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFP
Sbjct: 1141 IIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFP 1200

Query: 1201 MSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFK 1260
            MSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFK
Sbjct: 1201 MSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFK 1260

Query: 1261 EIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAIC 1320
            EIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAIC
Sbjct: 1261 EIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAIC 1320

Query: 1321 AVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFD 1380
            AVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFD
Sbjct: 1321 AVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFD 1380

Query: 1381 VNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQM 1440
            VNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQM
Sbjct: 1381 VNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQM 1440

Query: 1441 VRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKD 1500
            VRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKD
Sbjct: 1441 VRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKD 1500

Query: 1501 LPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGS 1560
            LPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGS
Sbjct: 1501 LPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGS 1560

Query: 1561 YSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASP 1620
            YSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASP
Sbjct: 1561 YSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASP 1620

Query: 1621 RKTKSLSLESTDRGSWDP 1638
            RKTKSLSLESTDRGSWDP
Sbjct: 1621 RKTKSLSLESTDRGSWDP 1638


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
            sapiens]
          Length = 1719

 Score = 3154 bits (8177), Expect = 0.0
 Identities = 1594/1719 (92%), Positives = 1615/1719 (93%), Gaps = 81/1719 (4%)

Query: 1    MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
            MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA
Sbjct: 1    MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60

Query: 61   KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
            KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA
Sbjct: 61   KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120

Query: 121  CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
            CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
Sbjct: 121  CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180

Query: 181  YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
            YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT
Sbjct: 181  YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240

Query: 241  PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
            PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER
Sbjct: 241  PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300

Query: 301  FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
            FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
Sbjct: 301  FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360

Query: 361  EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
            EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA
Sbjct: 361  EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420

Query: 421  GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
            GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP
Sbjct: 421  GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480

Query: 481  LTASKDLE------------------------------------------------IKNL 492
            LTASKDLE                                                IK L
Sbjct: 481  LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540

Query: 493  KEEIEKLRKQVTESS----HLEQQLEEANAVRQELDDAF------------------RQI 530
            ++E E L K++ ++S    +  ++L++A+  R+     F                  R +
Sbjct: 541  QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600

Query: 531  KAYEKQIKTLQQEREDLNK-----------LEVHTEALAAEASKDRKLREQSEHYSKQLE 579
            +  E+++  + Q+ E L +           LEVHTEALAAEASKDRKLREQSEHYSKQLE
Sbjct: 601  RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE 660

Query: 580  NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 639
            NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
Sbjct: 661  NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 720

Query: 640  ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 699
            ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT
Sbjct: 721  ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 780

Query: 700  SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 759
            SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA
Sbjct: 781  SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 840

Query: 760  LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 819
            LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
Sbjct: 841  LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 900

Query: 820  NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP 879
            NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP
Sbjct: 901  NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP 960

Query: 880  TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM 939
            TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM
Sbjct: 961  TDALDQFETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLM 1020

Query: 940  VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK 999
            VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK
Sbjct: 1021 VGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPK 1080

Query: 1000 PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH 1059
            PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH
Sbjct: 1081 PAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIH 1140

Query: 1060 ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV 1119
            ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV
Sbjct: 1141 ASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSV 1200

Query: 1120 YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL 1179
            YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL
Sbjct: 1201 YVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIEL 1260

Query: 1180 IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA 1239
            IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA
Sbjct: 1261 IPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVA 1320

Query: 1240 MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS 1299
            MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS
Sbjct: 1321 MKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYS 1380

Query: 1300 MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS 1359
            MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS
Sbjct: 1381 MLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPS 1440

Query: 1360 SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN 1419
            SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN
Sbjct: 1441 SCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKN 1500

Query: 1420 KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN 1479
            KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN
Sbjct: 1501 KMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISN 1560

Query: 1480 PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG 1539
            PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG
Sbjct: 1561 PTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSG 1620

Query: 1540 LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS 1599
            LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS
Sbjct: 1621 LSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDS 1680

Query: 1600 PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1638
            PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP
Sbjct: 1681 PRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP 1719


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score = 1939 bits (5022), Expect = 0.0
 Identities = 1006/1749 (57%), Positives = 1271/1749 (72%), Gaps = 151/1749 (8%)

Query: 1    MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
            MS +VRL++LEQ +LDGP + N    SVETLLD+L+CLY EC++S LRR+K + E+LEWA
Sbjct: 1    MSAKVRLKKLEQLLLDGPWR-NESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWA 59

Query: 61   KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
            KPFT  VK+M+LHREDFEI+KVIGRGAFGEVAVVK+KN ++++AMKILNKWEMLKRAETA
Sbjct: 60   KPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETA 119

Query: 121  CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
            CFREERDVLVNGD +WIT LHYAFQD+N+LYLVMDYYVGGDLLTLLSKFED+LPEDMARF
Sbjct: 120  CFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARF 179

Query: 181  YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
            Y+ EMV+AIDS+HQLHYVHRDIKPDN+L+D+NGHIRLADFGSCLK+ +DGTVQSSVAVGT
Sbjct: 180  YIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGT 239

Query: 241  PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
            PDYISPEILQAMEDG G+YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH+ER
Sbjct: 240  PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEER 299

Query: 301  FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
            FQFP+ VTDVSE AKDLI+RLICSRE RLGQNGIEDFKKH FF G++W+NIRN EAPYIP
Sbjct: 300  FQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIP 359

Query: 361  EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
            +VSSP+DTSNFDVDDD L+N+E +PP +HT FSG HLPF+GFT+T+    SDR  L+   
Sbjct: 360  DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419

Query: 421  GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
               +L  D +VQR L+++L  EAYERRI+RLEQEKLELSRKLQESTQTVQ+L  S+    
Sbjct: 420  QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS-RAL 478

Query: 481  LTASKDLEIKNLKEEIEK----------LRKQVTESSHLEQQLEEAN-----------AV 519
              +++D EIK L EEIE+          L +Q+ ++  L Q+ E++             V
Sbjct: 479  SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538

Query: 520  RQELDDAFRQI-------KAYEKQIKTLQQERE-------DLNK---------------- 549
            RQE ++  +Q+       K+  K++K   Q+R+       +LN+                
Sbjct: 539  RQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQL 598

Query: 550  ------------------------------LEVHTEALAAEASKDRKLREQSEHYSKQLE 579
                                          LE   +   AEASK+RKLRE SE++ KQ+E
Sbjct: 599  RDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQME 658

Query: 580  NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 639
            +ELE LK KQ     G  ++EHQQEI+K+K++LEKK +FYEEEL +RE  H  E+KN+KK
Sbjct: 659  SELEALKVKQGGRGAGA-TLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKK 717

Query: 640  ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 699
            E+HDSE  QLAL KEI++LKDKLEK++RE  +E EE     K +YERE+ +L +ENKKLT
Sbjct: 718  EVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLT 777

Query: 700  SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 759
            +E +KL +  + L+  N+QLE+E++DLA KKESVAHWEAQI EIIQWVSDEKDARGYLQA
Sbjct: 778  AENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQA 837

Query: 760  LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 819
            LASKMTEELEALR+SSLG+R  D  WK+RR  KLDMSARLELQSAL+AEIRAKQ +QEEL
Sbjct: 838  LASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEEL 897

Query: 820  NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGIEHQDSQHSFLAFLNT 878
             KVK +N+  E KLKDSE KN ELL E+E L K  EE  R++ G++  D Q S   + NT
Sbjct: 898  RKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNT 957

Query: 879  PTDALD-QFETVDSTPLSVHTPT------------------LRKKGCPGSTGFP------ 913
               A D  F T  ++      P                    R    P +   P      
Sbjct: 958  APLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALA 1017

Query: 914  ---PKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPV 970
               PK K HQF +KSF++PT+C  CTSLMVGLIRQG +CEVC F+CH++C + AP  CP+
Sbjct: 1018 LAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPI 1077

Query: 971  PPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKAS 1030
            PPEQ+K PLG+D Q+GIGTAY+GHV++PKP GVKKGWQRA A+VCD KLFLYD+ EGK++
Sbjct: 1078 PPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKST 1137

Query: 1031 QPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLAD 1090
            QP V+ SQV+D+RD+EFSVSSVLASDVIHA+R+DIPCIFRVTAS L A +   S+L+L +
Sbjct: 1138 QPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTE 1197

Query: 1091 TENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALG 1150
             ENEK KWVG+L  L  IL KN+ R++ V+VP EAYDS+LPLIK    AAI+D +RIA+G
Sbjct: 1198 NENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVG 1257

Query: 1151 NEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETD 1210
             EEGL+V+ VT+D I+R  D KK+HQIEL P +++V ++ GRN HV L+P S+LDG E  
Sbjct: 1258 LEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGS 1317

Query: 1211 F-YKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQ 1269
            F  KL ETKGCQ + +  ++  + TCL VA+KR +LCYE+ ++K  HRKF EI  P +VQ
Sbjct: 1318 FDIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQ 1377

Query: 1270 WMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEY 1329
             +A+  ++LCVG+ SGF    + G+G P ++++ ND +L+F++ Q  DA+CAVE+ S+EY
Sbjct: 1378 CLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEY 1437

Query: 1330 LLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQT 1389
            LLCF+ +G+Y D QGRR+R QELMWPA P +C  +  +++VYSE  VD+FDV +MEW+QT
Sbjct: 1438 LLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQT 1497

Query: 1390 LPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRR 1449
            + L+++RPLN+EG+LNLL  E  RLIYFK+K + G  L VP+TSDNS+KQM+R   +KRR
Sbjct: 1498 IGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFS-GAVLNVPDTSDNSKKQMLRT-RSKRR 1555

Query: 1450 YSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQE 1509
            + F+VPEEER+QQRREMLRDPE+R+K+ISNPTNFNH+AHMGPGDG+Q+L DLP++     
Sbjct: 1556 FVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLS----- 1610

Query: 1510 SRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMP 1569
                     ++P   + RP P     A + L+ +  ++N   +    SGGS  +   P+ 
Sbjct: 1611 ---------AVPPSQEERPGP-----APTNLARQPPSRNKPYISWPSSGGSEPSVTVPLR 1656

Query: 1570 SPSEGSLSSGGMDQGSDAPARDFDGE-DSDSPRHSTASNSSNLSSPPSPASPRKTKSLSL 1628
            S S+              P +DFD E DSDS +HST SNSSN S PPSP SP +++ L L
Sbjct: 1657 SMSD--------------PDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQ-LPL 1701

Query: 1629 ESTDRGSWD 1637
            E  ++ + D
Sbjct: 1702 EGLEQPACD 1710


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
            sapiens]
          Length = 1551

 Score = 1333 bits (3451), Expect = 0.0
 Identities = 748/1630 (45%), Positives = 1029/1630 (63%), Gaps = 147/1630 (9%)

Query: 4    EVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPF 63
            E RLR LEQ +  G A   G C  ++ LLD+L+ L+ E ++ PLRRE+++ ++L WA PF
Sbjct: 2    ERRLRALEQ-LARGEA---GGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPF 57

Query: 64   TSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFR 123
             SKVK++RL R+DFEILKVIGRGAFGEV VV+ ++  ++FAMK+L+KWEMLKRAETACFR
Sbjct: 58   VSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFR 117

Query: 124  EERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
            EERDVLV GD++W+TTLHYAFQD+  LYLVMDYY GGDLLTLLS+FEDRLP ++A+FYLA
Sbjct: 118  EERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLA 177

Query: 184  EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 243
            EMV+AI S+HQL YVHRD+KPDN+L+D+NGHIRLADFGSCL+L  +G V SSVAVGTPDY
Sbjct: 178  EMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDY 237

Query: 244  ISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQF 303
            ISPEILQAME+GKG YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNH++  QF
Sbjct: 238  ISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQF 297

Query: 304  PAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVS 363
            P  V DV  +A+DLIR+L+C +E RLG+ G++DF+ HPFF G+DW+ + +  APYIPE+ 
Sbjct: 298  PPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELR 357

Query: 364  SPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPT 423
             P DTSNFDVDDD L +  T+PPP+H AFSGHHLPFVGFTYTS            +  P 
Sbjct: 358  GPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSG-----------SHSPE 406

Query: 424  SLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTA 483
            S            ++ A  A ER+++ LEQEK+ELSRK QE+                  
Sbjct: 407  S------------SSEAWAALERKLQCLEQEKVELSRKHQEALH--------------AP 440

Query: 484  SKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANA-----------VRQELDDAFRQ--- 529
            +   E++ L++E++ LR ++ E    +  L + +            +RQELD   R+   
Sbjct: 441  TDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAE 500

Query: 530  ----IKAYEKQIKTLQ-QEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEG 584
                ++A E+++   Q Q+ E L +L+   E  AA AS+ R L  Q E  ++  + ELE 
Sbjct: 501  GRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEE-ARAAQRELEA 559

Query: 585  LKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIH-ANEIKNLKKELHD 643
                Q+S           +++T+L+   E++     EE S+ + IH A+E   +     +
Sbjct: 560  ----QVS--------SLSRQVTQLQGQWEQRL----EESSQAKTIHTASETNGMGPP--E 601

Query: 644  SEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELD 703
               Q+  L KE+  L+++LE+      S +EE   +           L EEN++L+ E +
Sbjct: 602  GGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQ-----------LQEENRRLSREQE 650

Query: 704  KLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASK 763
            +L           Q+LE E      ++E+ ++WEAQ+ +I+ WV+DEK +RGYLQALA+K
Sbjct: 651  RLEAELAQEQESKQRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYLQALATK 704

Query: 764  MTEELEALRN---SSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELN 820
            M EELE+LRN    +L  R  D  WK RR  K++ SARLELQSAL+AEIRAKQ +QE L 
Sbjct: 705  MAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLT 764

Query: 821  KVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQH--SFLAFLNT 878
            +V+ + +  E +L+++EK++  L  E+  L    EELR+   ++ + S     FL+F ++
Sbjct: 765  QVQEAQLQAERRLQEAEKQSQALQQELAML---REELRARGPVDTKPSNSLIPFLSFRSS 821

Query: 879  PTDALDQFETVDSTPLSVHTPTLRKKG-----------------CPGSTGFPPKRKTHQF 921
              D+                P LR +G                    + G P K  +H  
Sbjct: 822  EKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTL 881

Query: 922  FVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGI 981
              +SF +PTKC +CTSLM+GL RQG  C+ CG+ CH TC  +AP  CPVPP+  +  LG+
Sbjct: 882  RPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAP-PCPVPPDLLRTALGV 940

Query: 982  DPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVID 1041
             P+ G GTAYEG + +P+P+GV++GWQR  A + D +L L+D  + + S PS  + QV+D
Sbjct: 941  HPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLD 1000

Query: 1042 MRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGV 1101
            +RD +FS + VLASDVIHA  +D+P IFRVT SQL+     C++L+LA++E E+ +W+ V
Sbjct: 1001 LRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQV 1060

Query: 1102 LSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVT 1161
            L EL ++L   + R R VY  KEAYD+ LPL+  T  AAI+D +R+ALG EEGLFV+H+ 
Sbjct: 1061 LGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLR 1120

Query: 1162 KDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQ 1221
             ++I +VG+ +++ Q+ L P+  L+ V+ GR   VRLF ++ L+  E    K+ E++GCQ
Sbjct: 1121 SNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQ 1180

Query: 1222 TVTSGKVRHGALTCLCVAMKRQVLCYELFQSK-TRHRKFKEIQVPYNVQWMAIFSEQLCV 1280
             + +G +       LCVA+KRQVLCY+L        R+ +E+Q P  VQ + +  ++LCV
Sbjct: 1181 VLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCV 1240

Query: 1281 GFQSGFLRYPLNGEGNPYSM-LHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIY 1339
            G   GF  YPL  E  P ++        L        +A+ AVE+S  E+LL F + GIY
Sbjct: 1241 GAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIY 1300

Query: 1340 TDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLN 1399
             D  GR+SR  EL+WPA P    Y APYL+V+SEN++D+FDV   EW+QT+PLKKVRPLN
Sbjct: 1301 VDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLN 1360

Query: 1400 NEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEER 1459
             EGSL L G E +RL Y +N++AE DE  +P+ +DNSR+Q+ R   +KRR+ FRV EE++
Sbjct: 1361 PEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRT-KSKRRFFFRVSEEQQ 1419

Query: 1460 MQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVS 1519
             QQRREML+DP +R+KLIS PTNFNH+ H+GP +G    +D   +P P+E   V  GS  
Sbjct: 1420 KQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD--KSPAPEEKGRVARGS-- 1475

Query: 1520 IPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSG 1579
                      P R  S S  L  R  A  GS       G +   KR+P  S S  S+S  
Sbjct: 1476 ---------GPQRPHSFSEAL--RRPASMGS---EGLGGDADPMKRKPWTSLSSESVS-- 1519

Query: 1580 GMDQGSDAPA 1589
               QGS +PA
Sbjct: 1520 -CPQGSLSPA 1528


>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
           sapiens]
          Length = 625

 Score =  521 bits (1342), Expect = e-147
 Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)

Query: 1   MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
           MS EVRLR+L+Q +LD           +E LLD+L+ ++ E   S L ++K + ++L+WA
Sbjct: 1   MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54

Query: 61  KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
           +P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E +
Sbjct: 55  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114

Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
           CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174

Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
           YLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234

Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
           PDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294

Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
           E    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354

Query: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
            P+    TDT NFD+ +D L   ET+      A  G HLPFVG++Y S   L D      
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409

Query: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
             GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+  T++ L
Sbjct: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466

Query: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
           Q +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+   RQ+  
Sbjct: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515

Query: 533 YEKQIKTLQQE 543
            +++++ LQ E
Sbjct: 516 -QERMELLQAE 525


>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
           sapiens]
          Length = 624

 Score =  521 bits (1342), Expect = e-147
 Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)

Query: 1   MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
           MS EVRLR+L+Q +LD           +E LLD+L+ ++ E   S L ++K + ++L+WA
Sbjct: 1   MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54

Query: 61  KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
           +P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E +
Sbjct: 55  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114

Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
           CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174

Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
           YLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234

Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
           PDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294

Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
           E    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354

Query: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
            P+    TDT NFD+ +D L   ET+      A  G HLPFVG++Y S   L D      
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409

Query: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
             GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+  T++ L
Sbjct: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466

Query: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
           Q +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+   RQ+  
Sbjct: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515

Query: 533 YEKQIKTLQQE 543
            +++++ LQ E
Sbjct: 516 -QERMELLQAE 525


>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
           sapiens]
          Length = 629

 Score =  516 bits (1329), Expect = e-146
 Identities = 279/556 (50%), Positives = 374/556 (67%), Gaps = 39/556 (7%)

Query: 1   MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
           MS EVRLR+L+Q +LD           +E LLD+L+ ++ E   S L ++K + ++L+WA
Sbjct: 1   MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54

Query: 61  KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
           +P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E +
Sbjct: 55  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114

Query: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
           CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174

Query: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
           YLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVGT
Sbjct: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234

Query: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
           PDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++K
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294

Query: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
           E    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P+
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354

Query: 359 IPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDR 413
            P+    TDT NFD+ +D L        ET+      A  G HLPFVG++Y S   L D 
Sbjct: 355 TPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRDS 413

Query: 414 SCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQ 467
                  GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+  
Sbjct: 414 E----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEV 466

Query: 468 TVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAF 527
           T++ LQ +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+   
Sbjct: 467 TLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHV 517

Query: 528 RQIKAYEKQIKTLQQE 543
           RQ+   +++++ LQ E
Sbjct: 518 RQL---QERMELLQAE 530


>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
           sapiens]
          Length = 639

 Score =  478 bits (1230), Expect = e-134
 Identities = 257/497 (51%), Positives = 338/497 (68%), Gaps = 33/497 (6%)

Query: 60  AKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAET 119
           A+P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E 
Sbjct: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123

Query: 120 ACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAR 179
           +CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MAR
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183

Query: 180 FYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 239
           FYLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243

Query: 240 TPDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297
           TPDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303

Query: 298 KERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAP 357
           KE    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363

Query: 358 YIPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSD 412
           + P+    TDT NFD+ +D L        ET+      A  G HLPFVG++Y S   L D
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRD 422

Query: 413 RSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQEST 466
                   GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+ 
Sbjct: 423 SE----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAE 475

Query: 467 QTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDA 526
            T++ LQ +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+  
Sbjct: 476 VTLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAH 526

Query: 527 FRQIKAYEKQIKTLQQE 543
            RQ+   +++++ LQ E
Sbjct: 527 VRQL---QERMELLQAE 540


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score =  452 bits (1164), Expect = e-127
 Identities = 374/1253 (29%), Positives = 611/1253 (48%), Gaps = 223/1253 (17%)

Query: 2    SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
            S E R  +++  + D  ++ N  C     LLD L  L  + +   LR+ KNI  +L   K
Sbjct: 6    SFETRFEKMDNLLRDPKSEVNSDC-----LLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60

Query: 62   PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
               +K++ +R+  ED+E++KVIGRGAFGEV +V+ K+  KV+AMK+L+K+EM+KR+++A 
Sbjct: 61   DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120

Query: 122  FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
            F EERD++   ++ W+  L YAFQDD  LY+VM+Y  GGDL+ L+S ++  +PE  ARFY
Sbjct: 121  FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFY 178

Query: 182  LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
             AE+V+A+D++H + ++HRD+KPDN+L+D +GH++LADFG+C+K+ ++G V+   AVGTP
Sbjct: 179  TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 238

Query: 242  DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
            DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNHK   
Sbjct: 239  DYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSL 297

Query: 302  QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDW--DNIRNCEAPYI 359
             FP    D+S+ AK+LI   +  RE RLG+NG+E+ K+H FF    W  + +R+  AP +
Sbjct: 298  TFPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVV 356

Query: 360  PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVT 419
            P++SS  DTSNFD  ++     ET P P   AF G+ LPFVGFTY S+      S     
Sbjct: 357  PDLSSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTYYSN--RRYLSSANPN 412

Query: 420  AGPTSLDLDVNVQRTLDNN-----------------------------------LATEAY 444
               TS + D ++Q +L                                      L  E  
Sbjct: 413  DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472

Query: 445  ERR-----IKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKL 499
            +RR     + ++E+EK+ L  ++ E  +  +       +     + + E+  LK+++E L
Sbjct: 473  QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQ------ENEKRRNVENEVSTLKDQLEDL 526

Query: 500  RKQVTES-------SHLEQQLEEAN-AVRQELDDAFRQIKAYEK------QIKTLQQERE 545
            +K    S       S L++QLEEAN  +R E D A R  K++ +      Q+++L +E +
Sbjct: 527  KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQ 586

Query: 546  DLNKLEVHT-----------EALAAEASKDR---------------KLREQSEHYSKQLE 579
            + N++  ++           +A+     +DR                L+E+ +H    LE
Sbjct: 587  ERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLE 646

Query: 580  NELEGLK---QKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHA----- 631
             ++EG +   Q  +++S        ++E   L+ DL  K    ++ L +    H      
Sbjct: 647  -KVEGERKEAQDMLNHS--------EKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKAR 697

Query: 632  --------NEIKNL------KKELHDSEGQQLALNKEIMILKD--KLEKTRRESQSEREE 675
                     E K++      KK   + E ++ A N+ + I K    L+   ++SQ + E 
Sbjct: 698  LTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEH 757

Query: 676  FESEFKQQYEREKVLLT-----EENKKLTSELDKLTTLYE--NLSIHNQQLEEEVKDLAD 728
                 K++ E E   LT     E NK+L  + +  T  +E  NL    +Q+++E+  L +
Sbjct: 758  LTGN-KERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLE 816

Query: 729  KKESVAHWEAQITEI-------IQWVSDEKDARGYLQAL----ASKMTEELEALRNSSLG 777
             K  +    AQ+T+        ++ + D+ +A  Y   L      ++ EE+E     +L 
Sbjct: 817  AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK 876

Query: 778  TRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL------NKVKASNIITEC 831
                    K     +LD++     ++  ++E  A+  ++E+       +K  AS    E 
Sbjct: 877  KIQELQNEKETLATQLDLA-----ETKAESEQLARGLLEEQYFELTQESKKAASRNRQEI 931

Query: 832  KLKDS-----EKKNLELLSEIEQLIKDTEEL-----------RSEKGIEHQDSQHSFLAF 875
              KD      E+ N  L  +IE L ++ EEL           + EK  E  + + +F   
Sbjct: 932  TDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKN 991

Query: 876  LNTP----TDALDQFETVDSTP------LSVHTPTLRKKGCPGSTGF----PPKRKTHQF 921
            +NT     T A+++   + +           +T  LRKK              + K +Q 
Sbjct: 992  INTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQM 1051

Query: 922  FVK--------SFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPP- 972
             VK              +C     L + L  +    E       +  ++ + +    P  
Sbjct: 1052 VVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQ--LRAKLLDLSDSTSVASFPSA 1109

Query: 973  EQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKK-GWQRALAIVCDFKLFLYDIAEGKA-S 1030
            ++T G L   P+  I    EG + +P    +K+ GW++   +V   K+  Y+  + K  S
Sbjct: 1110 DETDGNL---PESRI----EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQS 1162

Query: 1031 QPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKC 1083
             PS+V+       D+ F V  V   DV  A  ++IP IF++    L A+  +C
Sbjct: 1163 NPSMVLDI-----DKLFHVRPVTQGDVYRAETEEIPKIFQI----LYANEGEC 1206


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score =  451 bits (1160), Expect = e-126
 Identities = 315/976 (32%), Positives = 518/976 (53%), Gaps = 145/976 (14%)

Query: 2   SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
           +G  R R+LE  I D  +  N     VE+LLD L  L  + +   LR+ KNI  +L   +
Sbjct: 22  AGASRQRKLEALIRDPRSPIN-----VESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYE 76

Query: 62  PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
               K++ +++  ED++++KVIGRGAFGEV +V+ K + KV+AMK+L+K+EM+KR+++A 
Sbjct: 77  KIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF 136

Query: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
           F EERD++   ++ W+  L YAFQDD  LY+VM+Y  GGDL+ L+S ++  +PE  A+FY
Sbjct: 137 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFY 194

Query: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
            AE+V+A+D++H +  +HRD+KPDN+L+D +GH++LADFG+C+K+ E G V    AVGTP
Sbjct: 195 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 254

Query: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
           DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+HK   
Sbjct: 255 DYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL 313

Query: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
            FP +  ++S++AK+LI   +  RE RLG+NG+E+ ++HPFF      WDNIR   AP +
Sbjct: 314 CFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVV 372

Query: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFT-YTSSCVLSDRSCLRV 418
           PE+SS  D+SNFD  +D   + ET P P   AF G+ LPF+GFT Y  + +LSD    R 
Sbjct: 373 PELSSDIDSSNFDDIEDDKGDVETFPIP--KAFVGNQLPFIGFTYYRENLLLSDSPSCRE 430

Query: 419 TAGPTSL--DLDVNVQR---TLDNNL-----ATEAYERRIK----RLEQEKLELSRKLQE 464
           T    S   +    +Q+   TL+ +L     A E  E++ K    RLE+   EL  ++  
Sbjct: 431 TDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL 490

Query: 465 STQTVQALQYSTVDGPLTASKDLE------------------IKNLKEEIEKLRKQVTES 506
                 AL+    +  L   K+ E                  + +LK+++E L+K+   S
Sbjct: 491 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 550

Query: 507 -------SHLEQQLEEANA-VRQELDDAFRQIKAY---EKQIKTLQQEREDLN------- 548
                  + L++QL+E NA +R E D A R  K      KQI+ L+    DL        
Sbjct: 551 QISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLE 610

Query: 549 --KLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEIT 606
             KL++  E +  +++ + + R+++  +  ++ N+L+G           +C +E   +  
Sbjct: 611 TAKLKLEKEFINLQSALESERRDRT--HGSEIINDLQG----------RICGLEEDLKNG 658

Query: 607 KL---KTDLEKKSI-----FYEEELSKREGIHANEIKNLKKELHDSEGQQLA-------- 650
           K+   K +LEK+ +       E+E S  E     ++K +++ L   E +  A        
Sbjct: 659 KILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADK 718

Query: 651 -----------------LNKEIM---ILKDKLEKTRRESQSEREEFESEFKQQYE----- 685
                            + K+++    LK K+E    E++      + + KQ  +     
Sbjct: 719 NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL 778

Query: 686 -REKVLLTEENKKLT--------------SELDKLTTLYENLSIHNQQLEEEVKDLADKK 730
            ++K +L E+ + LT              ++L   T     L +  +QL++E   L + K
Sbjct: 779 LKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMK 838

Query: 731 ESVAHWEAQITE-------IIQWVSDEKDARGYLQALASKMTEEL--EALRNSSLGTRAT 781
            ++    A++ +        ++ + D+ +A  Y   L      EL  E    + LG    
Sbjct: 839 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQ 898

Query: 782 DMPWKMRRFAKLDMSARLELQ-SALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 840
               +++   +  ++A+LE+  +  D+E  A+   +E+ + ++   I+ E ++K+   ++
Sbjct: 899 QKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARH 957

Query: 841 LELLSEIEQLIKDTEE 856
            + L+E +  I   EE
Sbjct: 958 KQELTEKDATIASLEE 973



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 99/441 (22%), Positives = 194/441 (43%), Gaps = 74/441 (16%)

Query: 451  LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASK-----DLEIKNLKEEIEKLRKQVTE 505
            +E+ K E  +++++     + L+    +  L A K     D ++K  +++I +L KQ   
Sbjct: 725  IEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV 784

Query: 506  SSH--------LEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKLEVHTEAL 557
             +         +EQ+ ++    + +L    +Q+   +   K L+QE   L +++++ E  
Sbjct: 785  LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ 844

Query: 558  AAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSI 617
             AE    RK R+ ++   K+L+++LE  +     Y         + ++ +LK + E+K+ 
Sbjct: 845  NAEL---RKERQDADGQMKELQDQLEAEQYFSTLY---------KTQVRELKEECEEKT- 891

Query: 618  FYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE------SQS 671
                +L K       E++  K+EL D E   LA   EI + K   E+  R       S  
Sbjct: 892  ----KLGK-------ELQQKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDL 939

Query: 672  EREEF--ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK 729
            E+E+   E E K+   R K  LTE++  + S           L   N+ L  +V +LA++
Sbjct: 940  EKEKIMKELEIKEMMARHKQELTEKDATIAS-----------LEETNRTLTSDVANLANE 988

Query: 730  KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWK--- 786
            KE + +    + E +  + DE+ +   ++A   K       L+  ++   A  M  K   
Sbjct: 989  KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPV 1048

Query: 787  -------MRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKK 839
                   +RR  K +    +EL+S  +   +     Q+ELN+++A       ++ +  + 
Sbjct: 1049 KRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA-------QIAEESQI 1101

Query: 840  NLELLSEIEQLIKDTEELRSE 860
             +EL   ++    D E+LRS+
Sbjct: 1102 RIELQMTLDSKDSDIEQLRSQ 1122



 Score = 40.0 bits (92), Expect = 0.019
 Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 992  EGHVRIPKPAGVKK-GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVS 1050
            EG + +P     KK GW +   IV   K+  YD  + K      ++  +    D+ F V 
Sbjct: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDI----DKLFHVR 1209

Query: 1051 SVLASDVIHASRKDIPCIFRV 1071
             V  +DV  A  K+IP IF++
Sbjct: 1210 PVTQTDVYRADAKEIPRIFQI 1230


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  392 bits (1006), Expect = e-108
 Identities = 274/931 (29%), Positives = 464/931 (49%), Gaps = 90/931 (9%)

Query: 27  SVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRG 86
           S E +LD L  L++EC+   L + K++  ++       +++++++   +DFE+  ++G G
Sbjct: 47  SREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCG 106

Query: 87  AFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQD 146
            F EV VV+ K    ++AMK++ K  +L + + + F EER++L    + WI  L YAFQD
Sbjct: 107 HFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD 166

Query: 147 DNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDN 206
            N+LYLVM+Y  GGDLL+LL+++ED+L E++ +FYLAE+++A+ SVH + YVHRDIKP+N
Sbjct: 167 KNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPEN 226

Query: 207 ILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME-DGKGRYGPECDW 265
           IL+D  GHI+L DFGS  K+  +  V + + +GTPDY++PE+L  M  DGKG YG +CDW
Sbjct: 227 ILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDW 286

Query: 266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSR 325
           WS+GV  YEM+YG +PF   +   T+  IMN +   +FP     VS +  DLI+ L+C +
Sbjct: 287 WSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLLCGQ 345

Query: 326 EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMP 385
           + RL   G+     HPFFS IDW+NIRN   P++P + S  DTSNFD  +   KNS    
Sbjct: 346 KERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPE---KNSWVSS 399

Query: 386 PP---THTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATE 442
            P   + + FSG  LPFVGF+Y+ +  +  RS   V+   +        ++ L  +   +
Sbjct: 400 SPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQ 459

Query: 443 AYERRIKRLEQEKLELSRKLQE----STQTVQALQYSTVDGPL----TASKDLEIKNLKE 494
             + +  ++EQE   L R++ E     +Q    L+ S     L     A+   E  +LK 
Sbjct: 460 DSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKR 519

Query: 495 EIEKLRKQVTESS----HLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQE------- 543
            +E+ R +V++       L   + E +   QE+ +   Q +  E ++   Q E       
Sbjct: 520 SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSAR 579

Query: 544 -REDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQ 602
            R DL + E+    LAAE  K    R+ +E   K L+ + +G  +          + E Q
Sbjct: 580 RRSDLYESELRESRLAAEEFK----RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ 635

Query: 603 QEITKLKTDLEKKSIFYEEELSKREGIH------ANEIKNLKKELHDSEGQQLALNKEIM 656
            +I +L+  LEK      E     + I         E++ L+     SEG      ++ +
Sbjct: 636 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEG-----IRKKL 690

Query: 657 ILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHN 716
           +  ++LE+  RE+Q   +  E   KQ+ +  +  +   + ++  +L    TL   +  H 
Sbjct: 691 VEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE 750

Query: 717 QQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDAR---------------------- 754
           ++  E+ K L+++K  +   +++I  + Q + +  +A                       
Sbjct: 751 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS 810

Query: 755 -------------GYLQALASKMTEELEAL--RNSSLGTRATDMPWKMRRFAKLDMSARL 799
                        G L+A   K+ E+LE +  ++ S   R  ++  ++R  +      +L
Sbjct: 811 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKL 870

Query: 800 ELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRS 859
           EL+  L     + Q  + +L  ++A+    E +L+ ++       +E+E+   + EE   
Sbjct: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK-------TELEETTAEAEEEIQ 923

Query: 860 EKGIEHQDSQHSFLAFLNTPTDALDQFETVD 890
                  + Q  F A  N+ T   D  E ++
Sbjct: 924 ALTAHRDEIQRKFDALRNSCTVITDLEEQLN 954



 Score =  165 bits (418), Expect = 3e-40
 Identities = 216/1029 (20%), Positives = 438/1029 (42%), Gaps = 137/1029 (13%)

Query: 452  EQEKLELSRKLQESTQTVQALQYS-TVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLE 510
            E++KLEL R+L E   ++Q  +   T      A+ + +++  K E+E+       ++  E
Sbjct: 866  EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET------TAEAE 919

Query: 511  QQLEEANAVRQELD---DAFRQ----IKAYEKQIKTLQQEREDLNKLEVHTEALAAEASK 563
            ++++   A R E+    DA R     I   E+Q+  L ++  +LN    +      EAS 
Sbjct: 920  EEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 979

Query: 564  DR----KLREQSEHYSKQL-ENELEGLKQKQISYS-PGVCSIEHQQEITKLKTDLEKKSI 617
                  +LR + +H  +++ E E++   QKQ   +    C++  +Q +     DLE  + 
Sbjct: 980  ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM-----DLEALN- 1033

Query: 618  FYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFE 677
               +EL ++E     + +  +  L D + Q     +E+  + D    T ++S++  ++  
Sbjct: 1034 ---DELLEKE----RQWEAWRSVLGDEKSQFECRVRELQRMLD----TEKQSRARADQRI 1082

Query: 678  SEFKQ-------QYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 730
            +E +Q       +++ E + L +  K+   + + L+    +L   +  LE   + L  K 
Sbjct: 1083 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL 1142

Query: 731  ESVAHWEAQITEIIQWVSDEKDA-RGYLQALASKMTEELEALRNSSLGTRATDMPWKMRR 789
            E+    + ++ E    +  + D  + ++  L   + E L+  R   L T  +D+ +++  
Sbjct: 1143 ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD--RADLLKTERSDLEYQLEN 1200

Query: 790  FAKLDMSARLELQSALDAEIRAKQAIQEELNKV--KASNIITECK--------------- 832
               L    +++++  +  + +    +Q ++++   K   + +  K               
Sbjct: 1201 IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE 1260

Query: 833  LKDSEKKNLELLSEIEQLIKDTE-ELRS--EKGIEHQDSQHSFLAFLNTPTDALDQF--- 886
            LK + +K     +E+E+ ++ T  ELRS  E+    + + H   +   TP  A  Q    
Sbjct: 1261 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPS---TPATARQQIAMS 1317

Query: 887  ------ETVDSTPLSVHTPTLRKKGCPGSTGFPPKRKT-------HQFFVKSFTTPTKCH 933
                  E   S    +  P+ R+K       F  + K        H+F V      TKC 
Sbjct: 1318 AIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCA 1377

Query: 934  QCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTK-----------GPLGID 982
             C    V   RQ   C  C   CH  C    P TC +P E                 G+ 
Sbjct: 1378 VCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQ 1436

Query: 983  PQKGIGTAY-EGHVRIPKP-AGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVI 1040
             ++   + + EG +++P+     ++GW R   ++   K+ +YD    +A Q  V   ++ 
Sbjct: 1437 TKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELC 1496

Query: 1041 DMRDEEFSV-SSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWV 1099
             + D + S+  +V AS++ + ++ D+P I ++ +   +      ++ +LA +  +K +WV
Sbjct: 1497 -LPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWV 1555

Query: 1100 GVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQ----AAAIIDHERIALGNEEGL 1155
              L  +  +      R+++    K   +S L L    +           + + +G EEGL
Sbjct: 1556 TALESV--VAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGL 1613

Query: 1156 FVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLS 1215
            + ++V K+ +  V     + QI +I + + + +I+G  R + L  +  +       +  +
Sbjct: 1614 YALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPA 1673

Query: 1216 E----------TKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVP 1265
            +           KGC    +GK+ +G   C+C AM  +V+     ++ +++   KEI+  
Sbjct: 1674 QPDISPNIFEAVKGCHLFGAGKIENGL--CICAAMPSKVVILRYNENLSKYCIRKEIETS 1731

Query: 1266 YNVQWMAIFSEQLCVG----FQSGFLRYPLNGEGNPYSMLHSNDHTLS---FIAHQPMDA 1318
                 +   +  + +G    ++    +Y L         L  NDH+L+   F A      
Sbjct: 1732 EPCSCIHFTNYSILIGTNKFYEIDMKQYTLE------EFLDKNDHSLAPAVFAASSNSFP 1785

Query: 1319 ICAVEISS----KEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSEN 1374
            +  V+++S    +EYLLCF+  G++ D  GRRSR  +L W   P +  Y  PYL V   N
Sbjct: 1786 VSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFN 1845

Query: 1375 AVDIFDVNS 1383
            ++++ ++ +
Sbjct: 1846 SLEVIEIQA 1854


>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
          Length = 465

 Score =  308 bits (790), Expect = 2e-83
 Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)

Query: 66  KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
           ++K+ RL  EDFE LKVIGRGAFGEV +V+ K+   V+AMKIL K +ML++ +    R E
Sbjct: 78  RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137

Query: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
           RD+LV  D+ W+  + Y+FQD  NLYL+M++  GGD++TLL K +D L E+  +FY+AE 
Sbjct: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196

Query: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229
           V+AIDS+HQL ++HRDIKPDN+L+D  GH++L+DFG C                  L  D
Sbjct: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256

Query: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
            T Q+                     VGTPDYI+PE+   M+ G   Y   CDWWSLGV 
Sbjct: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311

Query: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
           MYEML G  PF +E+  ETY K+MN KE   FP +V  +SE AKDLI R  C  EHR+G 
Sbjct: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370

Query: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
            G+E+ K + FF G+DW++IR   A    E+ S  DTSNFD   + D LK +        
Sbjct: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430

Query: 390 TAFSGHHLPFVGFTY 404
           T +      F+ +TY
Sbjct: 431 TDYKNKDWVFINYTY 445


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  212 bits (540), Expect = 2e-54
 Identities = 133/367 (36%), Positives = 206/367 (56%), Gaps = 24/367 (6%)

Query: 62  PFTSKVKQ--MRLHREDFEILKVIGRGAFGEVAVVKLK---NADKVFAMKILNKWEMLKR 116
           P T  VK+   +     FE+LKV+G+G+FG+V +V+ K   +A +++AMK+L K   LK 
Sbjct: 56  PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK-ASLKV 114

Query: 117 AETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
            +    + ERD+LV  ++ +I  LHYAFQ +  LYL++D+  GGD+ T LSK E    E+
Sbjct: 115 RDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173

Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSV 236
             +FYLAE+ +A+D +HQL  V+RD+KP+NIL+D  GHI+L DFG   K   D   ++  
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232

Query: 237 AVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 296
             GT +Y++PE++      +  +    DWWS GV M+EML G  PF  +   ET   I+ 
Sbjct: 233 FCGTVEYMAPEVV-----NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL- 286

Query: 297 HKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLGQNGIEDFKKHPFFSGIDWDNI--RN 353
            K +   P     +S  A+ L+R L   +  +RLG  G+E+ K+H FF+ IDWD +  R 
Sbjct: 287 -KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKRE 342

Query: 354 CEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDR 413
            + P+ P    P DT  FD +       ++   P   A +  H  F GF++ ++ +  + 
Sbjct: 343 VQPPFKPASGKPDDTFCFDPEFTAKTPKDS---PGLPASANAHQLFKGFSFVATSIAEEY 399

Query: 414 SCLRVTA 420
               +T+
Sbjct: 400 KITPITS 406



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 90/285 (31%), Positives = 139/285 (48%), Gaps = 33/285 (11%)

Query: 75  EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN-GD 133
           E +E+ + IG G++           +  FA+KI++K    KR  +    EE ++L+  G 
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDPS----EEIEILMRYGQ 476

Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPEDMARFYLAEMVIAID 190
           +  I TL   F D   +YLV D   GG+LL  + K   F +R   D+    L  +   +D
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVD 532

Query: 191 SVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGTVQSSVAVGTPDYIS 245
            +H    VHRD+KP NIL MD +     IR+ DFG   +L  E+G + +     T ++++
Sbjct: 533 YLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY--TANFVA 590

Query: 246 PEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFP- 304
           PE+L  M+ G   Y   CD WSLGV  Y ML G TPF A    +T  +I+      +F  
Sbjct: 591 PEVL--MQQG---YDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSL 644

Query: 305 --AQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID 347
                 ++S+ AKDL+  ++    H+  +   E   KH + +  D
Sbjct: 645 SGGNWDNISDGAKDLLSHMLHMDPHQ--RYTAEQILKHSWITHRD 687


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  209 bits (531), Expect = 2e-53
 Identities = 125/344 (36%), Positives = 204/344 (59%), Gaps = 20/344 (5%)

Query: 77  FEILKVIGRGAFGEVAVV-KLKNAD--KVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
           FE+LKV+G+G++G+V +V K+K +D  +++AMK+L K   LK  +    + ERD+L   +
Sbjct: 67  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 125

Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
           + +I  LHYAFQ +  LYL++D+  GGDL T LSK E    E+  +FYLAE+ +A+D +H
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 184

Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
            L  ++RD+KP+NIL+D  GHI++ DFG   + + D   ++    GT +Y++PE++    
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMAPEVV---- 239

Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
             +  +    DWWS GV M+EML G  PF  +   ET   I+  K +   P  ++  +++
Sbjct: 240 -NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSGEAQS 296

Query: 314 -AKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
             + L +R  C+R    G +G+E+ K+HPFF  IDW+ +  +  + P+ P V  P DT +
Sbjct: 297 LLRALFKRNPCNR-LGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 355

Query: 371 FDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRS 414
           F  D +    + T  P    + + HHL F GF++ +S ++ + S
Sbjct: 356 F--DPEFTARTPTDSPGVPPSANAHHL-FRGFSFVASSLIQEPS 396



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 30/279 (10%)

Query: 62  PFTSKVKQMRLHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
           P   ++    +H  D +EI + IG G++        K  D  +A+KI++K    KR  + 
Sbjct: 407 PIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS- 462

Query: 121 CFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPED 176
              EE ++L+  G +  I TL   + D   +YLVM+   GG+LL  + +   F +R   D
Sbjct: 463 ---EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASD 519

Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILM-DMNGH---IRLADFGSCLKLMEDGTV 232
           +    L  +   +D +H    VHRD+KP NIL  D +G    IR+ DFG   K +  G  
Sbjct: 520 V----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-KQLRAGNG 574

Query: 233 QSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFY---AESLVE 289
                  T ++++PE+L+     +  Y   CD WSLG+ +Y ML G TPF     ++  E
Sbjct: 575 LLMTPCYTANFVAPEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 629

Query: 290 TYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHR 328
              +I + K           +S+ AKD++ +++    H+
Sbjct: 630 ILARIGSGKYALS-GGNWDSISDAAKDVVSKMLHVDPHQ 667


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  209 bits (531), Expect = 2e-53
 Identities = 125/344 (36%), Positives = 204/344 (59%), Gaps = 20/344 (5%)

Query: 77  FEILKVIGRGAFGEVAVV-KLKNAD--KVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
           FE+LKV+G+G++G+V +V K+K +D  +++AMK+L K   LK  +    + ERD+L   +
Sbjct: 59  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVN 117

Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
           + +I  LHYAFQ +  LYL++D+  GGDL T LSK E    E+  +FYLAE+ +A+D +H
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 176

Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
            L  ++RD+KP+NIL+D  GHI++ DFG   + + D   ++    GT +Y++PE++    
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-DHDKRAYSFCGTIEYMAPEVV---- 231

Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
             +  +    DWWS GV M+EML G  PF  +   ET   I+  K +   P  ++  +++
Sbjct: 232 -NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSGEAQS 288

Query: 314 -AKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
             + L +R  C+R    G +G+E+ K+HPFF  IDW+ +  +  + P+ P V  P DT +
Sbjct: 289 LLRALFKRNPCNR-LGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFH 347

Query: 371 FDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRS 414
           F  D +    + T  P    + + HHL F GF++ +S ++ + S
Sbjct: 348 F--DPEFTARTPTDSPGVPPSANAHHL-FRGFSFVASSLIQEPS 388



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 82/279 (29%), Positives = 134/279 (48%), Gaps = 30/279 (10%)

Query: 62  PFTSKVKQMRLHRED-FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
           P   ++    +H  D +EI + IG G++        K  D  +A+KI++K    KR  + 
Sbjct: 399 PIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDK---SKRDPS- 454

Query: 121 CFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPED 176
              EE ++L+  G +  I TL   + D   +YLVM+   GG+LL  + +   F +R   D
Sbjct: 455 ---EEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASD 511

Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNILM-DMNGH---IRLADFGSCLKLMEDGTV 232
           +    L  +   +D +H    VHRD+KP NIL  D +G    IR+ DFG   K +  G  
Sbjct: 512 V----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFA-KQLRAGNG 566

Query: 233 QSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFY---AESLVE 289
                  T ++++PE+L+     +  Y   CD WSLG+ +Y ML G TPF     ++  E
Sbjct: 567 LLMTPCYTANFVAPEVLK-----RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 621

Query: 290 TYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHR 328
              +I + K           +S+ AKD++ +++    H+
Sbjct: 622 ILARIGSGKYALS-GGNWDSISDAAKDVVSKMLHVDPHQ 659


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  206 bits (525), Expect = 1e-52
 Identities = 121/332 (36%), Positives = 195/332 (58%), Gaps = 24/332 (7%)

Query: 50  EKNILEYLEWAKP-FTSKVK---QMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAM 105
           ++++ E+L  AK  F  K +   Q   H + FE +K +G G+FG V +VK K     +AM
Sbjct: 13  QESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAM 72

Query: 106 KILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTL 165
           KIL+K +++K  +      E+ +L   +  ++  L ++F+D++NLY+VM+Y  GG++ + 
Sbjct: 73  KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSH 132

Query: 166 LSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLK 225
           L +   R  E  ARFY A++V+  + +H L  ++RD+KP+N+L+D  G+I++ DFG   +
Sbjct: 133 LRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 191

Query: 226 LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAE 285
           +      ++    GTP+Y++PEI+ +    KG Y    DWW+LGV +YEM  G  PF+A+
Sbjct: 192 VKG----RTWTLCGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFAD 242

Query: 286 SLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPF 342
             ++ Y KI++ K RF      +  S + KDL+R L+      R G  +NG+ D K H +
Sbjct: 243 QPIQIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297

Query: 343 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFD 372
           F+  DW  I  R  EAP+IP+   P DTSNFD
Sbjct: 298 FATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD 329


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  206 bits (525), Expect = 1e-52
 Identities = 125/336 (37%), Positives = 189/336 (56%), Gaps = 19/336 (5%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF+ LKVIG+G +G+V + K K+    +A+K+L K  +LK+ E +    ER VL+ N  +
Sbjct: 34  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  L Y+FQ    LY V+DY  GG+L   L + E R  E  ARFY AE+  AI  +H 
Sbjct: 94  PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 152

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ ++RD+KP+NIL+D  GH+ L DFG C + +E     S+   GTP+Y++PE+L+    
Sbjct: 153 LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFC-GTPEYLAPEVLR---- 207

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
            K  Y    DWW LG  +YEML+G  PFY++ + + Y  I++  +  Q P   T     A
Sbjct: 208 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVA---A 261

Query: 315 KDLIRRLI-CSREHRLGQNG-IEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
            DL++ L+   +  RLG      + K H FFS I+WD++  +    P+ P V+ P D  +
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321

Query: 371 FDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTY 404
           FD +   + +  S    P T  + SG    F+GF+Y
Sbjct: 322 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  206 bits (525), Expect = 1e-52
 Identities = 125/336 (37%), Positives = 189/336 (56%), Gaps = 19/336 (5%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF+ LKVIG+G +G+V + K K+    +A+K+L K  +LK+ E +    ER VL+ N  +
Sbjct: 94  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  L Y+FQ    LY V+DY  GG+L   L + E R  E  ARFY AE+  AI  +H 
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 212

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ ++RD+KP+NIL+D  GH+ L DFG C + +E     S+   GTP+Y++PE+L+    
Sbjct: 213 LNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFC-GTPEYLAPEVLR---- 267

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
            K  Y    DWW LG  +YEML+G  PFY++ + + Y  I++  +  Q P   T     A
Sbjct: 268 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVA---A 321

Query: 315 KDLIRRLI-CSREHRLGQNG-IEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTSN 370
            DL++ L+   +  RLG      + K H FFS I+WD++  +    P+ P V+ P D  +
Sbjct: 322 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381

Query: 371 FDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTY 404
           FD +   + +  S    P T  + SG    F+GF+Y
Sbjct: 382 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  206 bits (523), Expect = 2e-52
 Identities = 116/312 (37%), Positives = 187/312 (59%), Gaps = 20/312 (6%)

Query: 71  RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 130
           RL  ++F  +KV+G+G+FG+V + +LK  D+V+A+K+L K  +L+  +  C   E+ +L 
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461

Query: 131 NG-DNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAI 189
               + ++T L+  FQ  + L+ VM+Y  GGDL+  + +   +  E  +RFY AE+  A+
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSR-KFDEPRSRFYAAEVTSAL 520

Query: 190 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 249
             +HQ   ++RD+K DNIL+D  GH +LADFG C + + +G V ++   GTPDYI+PEIL
Sbjct: 521 MFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDYIAPEIL 579

Query: 250 QAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTD 309
           Q +E     YGP  DWW+LGV MYEM+ G+ PF A++  + +  I++  +   +P     
Sbjct: 580 QELE-----YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYPVW--- 629

Query: 310 VSENAKDLIRRLICSREH-RLG----QNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEV 362
           +S+ A  +++  +    H RLG    QNG +  K+HPFF  IDW  +  +  + P+ P +
Sbjct: 630 LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRI 689

Query: 363 SSPTDTSNFDVD 374
            +  D +NFD D
Sbjct: 690 KTKRDVNNFDQD 701



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 3/70 (4%)

Query: 919 HQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPE---QT 975
           H+F + ++  PT C  C SL+ GL+RQG  C+VC  + H  C       C V      + 
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302

Query: 976 KGPLGIDPQK 985
              LG+ P K
Sbjct: 303 LADLGVTPDK 312



 Score = 34.7 bits (78), Expect = 0.78
 Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 1/51 (1%)

Query: 919 HQFFVKSFTTPTKCHQCTSLMVGLI-RQGCSCEVCGFSCHITCVNKAPTTC 968
           H+F       PT C  C   + G+I +QG  C+VC    H  C     T C
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKC 220


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  206 bits (523), Expect = 2e-52
 Identities = 117/320 (36%), Positives = 186/320 (58%), Gaps = 25/320 (7%)

Query: 58  EWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 117
           +W  P      Q   H + FE +K +G G+FG V +VK K     +AMKIL+K +++K  
Sbjct: 22  KWESP-----AQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLK 76

Query: 118 ETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDM 177
           +      E+ +L   +  ++  L ++F+D++NLY+VM+Y  GG++ + L +   R  E  
Sbjct: 77  QIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPH 135

Query: 178 ARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVA 237
           ARFY A++V+  + +H L  ++RD+KP+N+L+D  G+I++ DFG   ++      ++   
Sbjct: 136 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTL 191

Query: 238 VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297
            GTP+Y++PEI+ +    KG Y    DWW+LGV +YEM  G  PF+A+  ++ Y KI++ 
Sbjct: 192 CGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 246

Query: 298 KERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPFFSGIDWDNI--R 352
           K RF      +  S + KDL+R L+      R G  +NG+ D K H +F+  DW  I  R
Sbjct: 247 KVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR 301

Query: 353 NCEAPYIPEVSSPTDTSNFD 372
             EAP+IP+   P DTSNFD
Sbjct: 302 KVEAPFIPKFKGPGDTSNFD 321


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
           sapiens]
          Length = 1309

 Score =  206 bits (523), Expect = 2e-52
 Identities = 127/389 (32%), Positives = 207/389 (53%), Gaps = 24/389 (6%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNK 135
           DFE +K+I  GA+G V +V+ ++  + FA+K +NK  ++ R +      ERD+L   +N 
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425

Query: 136 WITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQL 195
           ++ ++  +F+   +L +VM+Y  GGD  TLL      LP DMAR Y AE V+A++ +H  
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484

Query: 196 HYVHRDIKPDNILMDMNGHIRLADFG-SCLKLME------DGTVQSSV-------AVGTP 241
             VHRD+KPDN+L+   GHI+L DFG S + LM       +G ++            GTP
Sbjct: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544

Query: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
           +YI+PE++      +  YG   DWW++GV +YE L G  PF+ ++  E +G++++  +  
Sbjct: 545 EYIAPEVI-----FRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DEI 597

Query: 302 QFPAQVTDVSENAKDLIRRLI-CSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
            +P     +  +A+DLI RL+  S   RLG  G  + K+HPFF  +DW  +   +A ++P
Sbjct: 598 MWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVP 657

Query: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLP-FVGFTYTSSCVLSDRSCLRVT 419
           ++ +  DTS FD   +  ++  +    T+   S   +P F   ++  S V S    L V 
Sbjct: 658 QLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQ 717

Query: 420 AGPTSLDLDVNVQRTLDNNLATEAYERRI 448
             PT  +   +  R      +   Y RR+
Sbjct: 718 PTPTFAERSFSEDREEGWERSEVDYGRRL 746


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  205 bits (521), Expect = 3e-52
 Identities = 122/332 (36%), Positives = 192/332 (57%), Gaps = 31/332 (9%)

Query: 57  LEWAKPFTSKVKQMRLHR-----------EDFEILKVIGRGAFGEVAVVKLKNADKVFAM 105
           +E  K F +K K+  L +           EDFE  K +G G+FG V +VK K  ++ +AM
Sbjct: 13  VESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 72

Query: 106 KILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTL 165
           KIL+K +++K  +      E+ +L   +  ++  L YAF+D++NLY+VM+Y  GG++ + 
Sbjct: 73  KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 132

Query: 166 LSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLK 225
           L +   R  E  ARFY A++V+  + +H L  ++RD+KP+N+L+D  G+I++ DFG   +
Sbjct: 133 LRRI-GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR 191

Query: 226 LMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAE 285
           +      ++    GTP+Y++PEI+ +    KG Y    DWW+LGV +YEM  G  PF+A+
Sbjct: 192 VKG----RTWTLCGTPEYLAPEIILS----KG-YNKAVDWWALGVLIYEMAAGYPPFFAD 242

Query: 286 SLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI-CSREHRLG--QNGIEDFKKHPF 342
             ++ Y KI++ K RF      +  S + KDL+R L+      R G  +NG+ D K H +
Sbjct: 243 QPIQIYEKIVSGKVRFP-----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKW 297

Query: 343 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFD 372
           F+  DW  I  R  EAP+IP+     DTSNFD
Sbjct: 298 FATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD 329


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  204 bits (519), Expect = 6e-52
 Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF  LKVIG+G+FG+V + + K  +  +A+K+L K  +LK+ E      ER+VL+ N  +
Sbjct: 97  DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  LH++FQ  + LY V+DY  GG+L   L + E    E  ARFY AE+  A+  +H 
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 215

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ V+RD+KP+NIL+D  GHI L DFG C + +E  +  S+   GTP+Y++PE+L     
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 270

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
            K  Y    DWW LG  +YEMLYG  PFY+ +  E Y  I+N       P Q+  +++ +
Sbjct: 271 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 323

Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
           A+ L+  L+   R  RLG ++   + K H FFS I+WD++ N     P+ P VS P D  
Sbjct: 324 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 383

Query: 370 NFD 372
           +FD
Sbjct: 384 HFD 386


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  204 bits (519), Expect = 6e-52
 Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF  LKVIG+G+FG+V + + K  +  +A+K+L K  +LK+ E      ER+VL+ N  +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  LH++FQ  + LY V+DY  GG+L   L + E    E  ARFY AE+  A+  +H 
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 229

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ V+RD+KP+NIL+D  GHI L DFG C + +E  +  S+   GTP+Y++PE+L     
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 284

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
            K  Y    DWW LG  +YEMLYG  PFY+ +  E Y  I+N       P Q+  +++ +
Sbjct: 285 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 337

Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
           A+ L+  L+   R  RLG ++   + K H FFS I+WD++ N     P+ P VS P D  
Sbjct: 338 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 397

Query: 370 NFD 372
           +FD
Sbjct: 398 HFD 400


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  204 bits (519), Expect = 6e-52
 Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF  LKVIG+G+FG+V + + K  +  +A+K+L K  +LK+ E      ER+VL+ N  +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  LH++FQ  + LY V+DY  GG+L   L + E    E  ARFY AE+  A+  +H 
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 243

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ V+RD+KP+NIL+D  GHI L DFG C + +E  +  S+   GTP+Y++PE+L     
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 298

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
            K  Y    DWW LG  +YEMLYG  PFY+ +  E Y  I+N       P Q+  +++ +
Sbjct: 299 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 351

Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
           A+ L+  L+   R  RLG ++   + K H FFS I+WD++ N     P+ P VS P D  
Sbjct: 352 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 411

Query: 370 NFD 372
           +FD
Sbjct: 412 HFD 414


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  204 bits (519), Expect = 6e-52
 Identities = 120/303 (39%), Positives = 178/303 (58%), Gaps = 19/303 (6%)

Query: 76  DFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV-NGDN 134
           DF  LKVIG+G+FG+V + + K  +  +A+K+L K  +LK+ E      ER+VL+ N  +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  LH++FQ  + LY V+DY  GG+L   L + E    E  ARFY AE+  A+  +H 
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 310

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L+ V+RD+KP+NIL+D  GHI L DFG C + +E  +  S+   GTP+Y++PE+L     
Sbjct: 311 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC-GTPEYLAPEVLH---- 365

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQV-TDVSEN 313
            K  Y    DWW LG  +YEMLYG  PFY+ +  E Y  I+N       P Q+  +++ +
Sbjct: 366 -KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK------PLQLKPNITNS 418

Query: 314 AKDLIRRLI-CSREHRLG-QNGIEDFKKHPFFSGIDWDNIRN--CEAPYIPEVSSPTDTS 369
           A+ L+  L+   R  RLG ++   + K H FFS I+WD++ N     P+ P VS P D  
Sbjct: 419 ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLR 478

Query: 370 NFD 372
           +FD
Sbjct: 479 HFD 481


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  204 bits (519), Expect = 6e-52
 Identities = 116/303 (38%), Positives = 182/303 (60%), Gaps = 20/303 (6%)

Query: 75  EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDN 134
           EDFE  K +G G+FG V +VK K  ++ +AMKIL+K +++K  +      E+ +L   + 
Sbjct: 89  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148

Query: 135 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQ 194
            ++  L YAF+D++NLY+VM+Y  GG++ + L +   R  E  ARFY A++V+  + +H 
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 207

Query: 195 LHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMED 254
           L  ++RD+KP+N+L+D  G+I++ DFG   ++      ++    GTP+Y++PEI+ +   
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILS--- 260

Query: 255 GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENA 314
            KG Y    DWW+LGV +YEM  G  PF+A+  ++ Y KI++ K RF      +  S + 
Sbjct: 261 -KG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP-----SHFSSDL 313

Query: 315 KDLIRRLI-CSREHRLG--QNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDTS 369
           KDL+R L+      R G  +NG+ D K H +F+  DW  I  R  EAP+IP+     DTS
Sbjct: 314 KDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTS 373

Query: 370 NFD 372
           NFD
Sbjct: 374 NFD 376


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  204 bits (518), Expect = 7e-52
 Identities = 140/380 (36%), Positives = 210/380 (55%), Gaps = 35/380 (9%)

Query: 77  FEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
           FE+LKV+G+G+FG+V +VK     +A +++AMK+L K   LK  +    + ERD+LV  +
Sbjct: 68  FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKK-ATLKVRDRVRTKMERDILVEVN 126

Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
           + +I  LHYAFQ +  LYL++D+  GGDL T LSK E    E+  +FYLAE+ +A+D +H
Sbjct: 127 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 185

Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
            L  ++RD+KP+NIL+D  GHI+L DFG   K   D   ++    GT +Y++PE++    
Sbjct: 186 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKESIDHEKKAYSFCGTVEYMAPEVV---- 240

Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
             +  +    DWWS GV M+EML G  PF  +   ET   I+  K +   P     +S  
Sbjct: 241 -NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL--KAKLGMP---QFLSPE 294

Query: 314 AKDLIRRLI-CSREHRL--GQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDT 368
           A+ L+R L   +  +RL  G +G+E+ K+H FFS IDW+ +  R    P+ P    P DT
Sbjct: 295 AQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDT 354

Query: 369 SNFDVDDDCL--KNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLD 426
             FD +      K+S  +PP  +      H  F GF++  +    D S    T G  S+ 
Sbjct: 355 FYFDPEFTAKTPKDSPGIPPSANA-----HQLFRGFSFV-AITSDDESQAMQTVGVHSI- 407

Query: 427 LDVNVQRTLDNNLA-TEAYE 445
               VQ+   N++  T+ YE
Sbjct: 408 ----VQQLHRNSIQFTDGYE 423



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 87/296 (29%), Positives = 146/296 (49%), Gaps = 35/296 (11%)

Query: 71  RLHR------EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFRE 124
           +LHR      + +E+ + IG G++        K  +  FA+KI++K    KR  T    E
Sbjct: 410 QLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK---SKRDPT----E 462

Query: 125 ERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLA 183
           E ++L+  G +  I TL   + D   +Y+V +   GG+LL  + + +    E  A   L 
Sbjct: 463 EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR-QKFFSEREASAVLF 521

Query: 184 EMVIAIDSVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGTVQSSVAV 238
            +   ++ +H    VHRD+KP NIL +D +G+   IR+ DFG   +L  E+G + +    
Sbjct: 522 TITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY- 580

Query: 239 GTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
            T ++++PE+L+     +  Y   CD WSLGV +Y ML G TPF A    +T  +I+   
Sbjct: 581 -TANFVAPEVLK-----RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARI 633

Query: 299 ERFQFP---AQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI 351
              +F         VS+ AKDL+ +++    H+     +    +HP+   + WD +
Sbjct: 634 GSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAAL--VLRHPWI--VHWDQL 685


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  203 bits (517), Expect = 1e-51
 Identities = 126/349 (36%), Positives = 195/349 (55%), Gaps = 23/349 (6%)

Query: 71  RLHREDFEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRA-ETACFREER 126
           ++  E FE+L+V+G+G +G+V  V+     N  K+FAMK+L K  +++ A +TA  + ER
Sbjct: 85  KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 144

Query: 127 DVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMV 186
           ++L    + +I  L YAFQ    LYL+++Y  GG+L   L + E    ED A FYLAE+ 
Sbjct: 145 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER-EGIFMEDTACFYLAEIS 203

Query: 187 IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISP 246
           +A+  +HQ   ++RD+KP+NI+++  GH++L DFG C + + DGTV  +   GT +Y++P
Sbjct: 204 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC-GTIEYMAP 262

Query: 247 EILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQ 306
           EIL  M  G  R     DWWSLG  MY+ML G  PF  E+  +T  KI+  K +   P  
Sbjct: 263 EIL--MRSGHNR---AVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL--KCKLNLPPY 315

Query: 307 VTDVSENAKDLIRRLI---CSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEAPYIPE 361
           +T   + A+DL+++L+    +     G     + + HPFF  I+W+ +  R  E P+ P 
Sbjct: 316 LT---QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL 372

Query: 362 VSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVL 410
           + S  D S F  D    + +    P   T     +  F+GFTY +  VL
Sbjct: 373 LQSEEDVSQF--DSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  202 bits (514), Expect = 2e-51
 Identities = 127/356 (35%), Positives = 202/356 (56%), Gaps = 28/356 (7%)

Query: 77  FEILKVIGRGAFGEVAVVKL---KNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 133
           FE+LKV+G+G+FG+V +V+     ++  ++AMK+L K   LK  +    + ERD+L + +
Sbjct: 71  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKK-ATLKVRDRVRTKMERDILADVN 129

Query: 134 NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193
           + ++  LHYAFQ +  LYL++D+  GGDL T LSK E    E+  +FYLAE+ + +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 188

Query: 194 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 253
            L  ++RD+KP+NIL+D  GHI+L DFG   + + D   ++    GT +Y++PE++    
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI-DHEKKAYSFCGTVEYMAPEVV---- 243

Query: 254 DGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSEN 313
             +  +    DWWS GV M+EML G  PF  +   ET   I+  K +   P     +S  
Sbjct: 244 -NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLSTE 297

Query: 314 AKDLIRRLI-CSREHRLGQ--NGIEDFKKHPFFSGIDWDNI--RNCEAPYIPEVSSPTDT 368
           A+ L+R L   +  +RLG   +G E+ K+H F+S IDW+ +  R  + P+ P V+ P DT
Sbjct: 298 AQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 357

Query: 369 SNFDVD--DDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGP 422
             FD +      K+S  +PP      +G H  F GF++ ++ ++ D    R    P
Sbjct: 358 FYFDTEFTSRTPKDSPGIPPS-----AGAHQLFRGFSFVATGLMEDDGKPRAPQAP 408



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 82/280 (29%), Positives = 142/280 (50%), Gaps = 29/280 (10%)

Query: 62  PFTSKVKQMR----LHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 117
           P  S V+Q+     +  + + + + IG G++ E      K  +  +A+K+++K    KR 
Sbjct: 408 PLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRD 464

Query: 118 ETACFREERDVLVN-GDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPED 176
            +    EE ++L+  G +  I TL   + D  ++YLV +   GG+LL  + + +    E 
Sbjct: 465 PS----EEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR-QKFFSER 519

Query: 177 MARFYLAEMVIAIDSVHQLHYVHRDIKPDNIL-MDMNGH---IRLADFGSCLKLM-EDGT 231
            A F L  +   ++ +H    VHRD+KP NIL +D +G+   +R+ DFG   +L  E+G 
Sbjct: 520 EASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL 579

Query: 232 VQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETY 291
           + +     T ++++PE+L+     +  Y   CD WSLG+ +Y ML G TPF A    +T 
Sbjct: 580 LMTPCY--TANFVAPEVLK-----RQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTP 631

Query: 292 GKIMNHKERFQFP---AQVTDVSENAKDLIRRLICSREHR 328
            +I+      +F         VSE AKDL+ +++    H+
Sbjct: 632 EEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQ 671


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,160,526
Number of Sequences: 37866
Number of extensions: 3062819
Number of successful extensions: 26415
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 1561
Number of HSP's that attempted gapping in prelim test: 13548
Number of HSP's gapped (non-prelim): 7525
length of query: 1638
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1522
effective length of database: 13,855,062
effective search space: 21087404364
effective search space used: 21087404364
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.