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Search of human proteins with 30089932
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30089932 ankyrin repeat and SOCS box-containing 6 isoform 2
[Homo sapiens]
(197 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30089932 ankyrin repeat and SOCS box-containing 6 isoform 2 [... 402 e-113
gi|8923516 ankyrin repeat and SOCS box-containing 6 isoform 1 [H... 267 4e-72
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 53 1e-07
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 52 4e-07
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 52 4e-07
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 49 2e-06
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 49 2e-06
gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member ... 49 3e-06
gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member ... 49 3e-06
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 47 8e-06
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 47 8e-06
gi|8051593 GA binding protein transcription factor, beta subunit... 47 1e-05
gi|8051595 GA binding protein transcription factor, beta subunit... 47 1e-05
gi|32483404 GA binding protein transcription factor, beta subuni... 47 1e-05
gi|8051597 GA binding protein transcription factor, beta subunit... 47 1e-05
gi|8051599 GA binding protein transcription factor, beta subunit... 47 1e-05
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 47 1e-05
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 46 2e-05
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 46 2e-05
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 46 2e-05
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 46 2e-05
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 46 2e-05
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 45 4e-05
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 45 5e-05
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 45 5e-05
gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa... 44 9e-05
gi|10863929 ribonuclease L [Homo sapiens] 44 1e-04
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 44 1e-04
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 44 1e-04
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 44 1e-04
>gi|30089932 ankyrin repeat and SOCS box-containing 6 isoform 2
[Homo sapiens]
Length = 197
Score = 402 bits (1034), Expect = e-113
Identities = 197/197 (100%), Positives = 197/197 (100%)
Query: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
Sbjct: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
Query: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
Sbjct: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
Query: 121 LLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPA 180
LLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPA
Sbjct: 121 LLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWKEGQTSRPPPKMGTQCSPA 180
Query: 181 SSSCLVRPWEGTKRRPR 197
SSSCLVRPWEGTKRRPR
Sbjct: 181 SSSCLVRPWEGTKRRPR 197
>gi|8923516 ankyrin repeat and SOCS box-containing 6 isoform 1 [Homo
sapiens]
Length = 421
Score = 267 bits (683), Expect = 4e-72
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
Sbjct: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
Query: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
Sbjct: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
Query: 121 LLVHHGADVNRRDR 134
LLVHHGADVNRRDR
Sbjct: 121 LLVHHGADVNRRDR 134
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 53.1 bits (126), Expect = 1e-07
Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 11/113 (9%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPV 101
VA+ SR L+ SPF+ A GLT +LL +GA++N ++
Sbjct: 36 VAALASRKSARPTKLDSNGQSPFHLA---------ASKGLTECLTILLANGADINSKNE- 85
Query: 102 TYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTIL 154
TALH+A + QP V++L+ HGA+ + D E + W A++GC S++L
Sbjct: 86 DGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN-RSPLHWAASSGCASSVL 137
Score = 35.4 bits (80), Expect = 0.032
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +AS + ++LL+R A + +AL+ E G A++LL HGA+
Sbjct: 156 PLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAV 215
Query: 99 DPVTYYTALHIAV 111
D T + ALH A+
Sbjct: 216 DS-TGHDALHYAL 227
Score = 29.3 bits (64), Expect = 2.3
Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 74 LKMAELGLTRA-ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L +A LG A LL+ GA +N D +AL +A + ++ ELL+ HGAD
Sbjct: 157 LMIASLGGHAAICSQLLQRGARVNVTDK-NDKSALILACEKGSAEVAELLLSHGADAGAV 215
Query: 133 D 133
D
Sbjct: 216 D 216
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 51.6 bits (122), Expect = 4e-07
Identities = 33/80 (41%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
++T LL A G AL G AADVLL+HGAN+N +D V ++T LHIA
Sbjct: 116 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAV-FFTPLHIA 174
Query: 111 VLRNQPDMVELLVHHGADVN 130
+ LL+ GADVN
Sbjct: 175 AYYGHEQVTRLLLKFGADVN 194
Score = 32.0 bits (71), Expect = 0.35
Identities = 11/28 (39%), Positives = 21/28 (75%)
Query: 104 YTALHIAVLRNQPDMVELLVHHGADVNR 131
+TALH+AV ++ +++ L+H GAD+ +
Sbjct: 102 FTALHLAVYKDNAELITSLLHSGADIQQ 129
Score = 31.2 bits (69), Expect = 0.60
Identities = 13/29 (44%), Positives = 20/29 (68%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRD 133
TALHIA + + ++L+ HGA+VN +D
Sbjct: 136 TALHIATIAGHLEAADVLLQHGANVNIQD 164
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 51.6 bits (122), Expect = 4e-07
Identities = 33/80 (41%), Positives = 42/80 (52%), Gaps = 1/80 (1%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
++T LL A G AL G AADVLL+HGAN+N +D V ++T LHIA
Sbjct: 217 LITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAV-FFTPLHIA 275
Query: 111 VLRNQPDMVELLVHHGADVN 130
+ LL+ GADVN
Sbjct: 276 AYYGHEQVTRLLLKFGADVN 295
Score = 32.0 bits (71), Expect = 0.35
Identities = 11/28 (39%), Positives = 21/28 (75%)
Query: 104 YTALHIAVLRNQPDMVELLVHHGADVNR 131
+TALH+AV ++ +++ L+H GAD+ +
Sbjct: 203 FTALHLAVYKDNAELITSLLHSGADIQQ 230
Score = 31.2 bits (69), Expect = 0.60
Identities = 13/29 (44%), Positives = 20/29 (68%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRD 133
TALHIA + + ++L+ HGA+VN +D
Sbjct: 237 TALHIATIAGHLEAADVLLQHGANVNIQD 265
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 49.3 bits (116), Expect = 2e-06
Identities = 43/139 (30%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 604 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWK 162
+T L +A +VELL+ HGAD R ++ +ML AA G ++++ + Y
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG--STMLIEAAKGGHTSVVCYLLDY-P 720
Query: 163 EGQTSRPPPKMGTQCSPAS 181
S PPP + TQ +P S
Sbjct: 721 NNLLSAPPPDV-TQLTPPS 738
Score = 40.4 bits (93), Expect = 0.001
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1258 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFV 158
+ TAL IA + ELL+ GA ++ R+++ + LW AA G +++ V
Sbjct: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG--NTPLWLAANGGHLDVVQLLV 1373
Score = 38.5 bits (88), Expect = 0.004
Identities = 36/134 (26%), Positives = 61/134 (45%), Gaps = 3/134 (2%)
Query: 14 YQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNAL 73
++ LV +L G R + P +A+ + V+ LL+ A E +
Sbjct: 1095 HEELVQTLL-ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153
Query: 74 LKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L +A G ++LL GAN + V+ YT L +A +++++L++ GA++N R
Sbjct: 1154 LSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1212
Query: 133 DREKLLCSMLWPAA 146
KL S L AA
Sbjct: 1213 TGSKLGISPLMLAA 1226
Score = 36.2 bits (82), Expect = 0.019
Identities = 29/112 (25%), Positives = 49/112 (43%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A + L++ A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADV 129
G +LL GAN+N + T TAL +A ++ + L+ GAD+
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 35.0 bits (79), Expect = 0.041
Identities = 24/85 (28%), Positives = 37/85 (43%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
V+ LLE A + E L++ G A +LL +GA +N +AL +A
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLA 408
Query: 111 VLRNQPDMVELLVHHGADVNRRDRE 135
+ +MV L+ GAD + E
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDE 433
Score = 34.3 bits (77), Expect = 0.070
Identities = 37/146 (25%), Positives = 64/146 (43%), Gaps = 3/146 (2%)
Query: 29 DPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVL 88
D + + + D +A ++ LLER A + L+ A G ++L
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135
Query: 89 LRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATG 148
L +GA++ + T T L +A + ++VELL+ GA N+ R + L AA+G
Sbjct: 1136 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA--NKEHRNVSDYTPLSLAASG 1193
Query: 149 CRSTILRTFVSYWKEGQTSRPPPKMG 174
I++ ++ E SR K+G
Sbjct: 1194 GYVNIIKILLNAGAE-INSRTGSKLG 1218
Score = 31.6 bits (70), Expect = 0.46
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 55 LLERKA--HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVL 112
LL++ A ++P AL A+ G + ++L+ GA+++ + T L +A
Sbjct: 1304 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAAN 1362
Query: 113 RNQPDMVELLVHHGADVNRRDREKL 137
D+V+LLV GADV+ D K+
Sbjct: 1363 GGHLDVVQLLVQAGADVDAADNRKI 1387
Score = 28.5 bits (62), Expect = 3.9
Identities = 27/110 (24%), Positives = 43/110 (39%), Gaps = 1/110 (0%)
Query: 26 GIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAA 85
G + + + A + + V LL+ A + + L A G A
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
Query: 86 DVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+L+ GA+L E YT L A +MV LL+ GA++N + E
Sbjct: 484 ALLIERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 49.3 bits (116), Expect = 2e-06
Identities = 43/139 (30%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 604 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSYWK 162
+T L +A +VELL+ HGAD R ++ +ML AA G ++++ + Y
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG--STMLIEAAKGGHTSVVCYLLDY-P 720
Query: 163 EGQTSRPPPKMGTQCSPAS 181
S PPP + TQ +P S
Sbjct: 721 NNLLSAPPPDV-TQLTPPS 738
Score = 40.4 bits (93), Expect = 0.001
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1007 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1066
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFV 158
+ TAL IA + ELL+ GA ++ R+++ + LW AA G +++ V
Sbjct: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG--NTPLWLAANGGHLDVVQLLV 1122
Score = 38.5 bits (88), Expect = 0.004
Identities = 36/134 (26%), Positives = 61/134 (45%), Gaps = 3/134 (2%)
Query: 14 YQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNAL 73
++ LV +L G R + P +A+ + V+ LL+ A E +
Sbjct: 844 HEELVQTLL-ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
Query: 74 LKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L +A G ++LL GAN + V+ YT L +A +++++L++ GA++N R
Sbjct: 903 LSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAASGGYVNIIKILLNAGAEINSR 961
Query: 133 DREKLLCSMLWPAA 146
KL S L AA
Sbjct: 962 TGSKLGISPLMLAA 975
Score = 36.2 bits (82), Expect = 0.019
Identities = 29/112 (25%), Positives = 49/112 (43%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A + L++ A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADV 129
G +LL GAN+N + T TAL +A ++ + L+ GAD+
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 35.0 bits (79), Expect = 0.041
Identities = 24/85 (28%), Positives = 37/85 (43%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
V+ LLE A + E L++ G A +LL +GA +N +AL +A
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLA 408
Query: 111 VLRNQPDMVELLVHHGADVNRRDRE 135
+ +MV L+ GAD + E
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDE 433
Score = 34.3 bits (77), Expect = 0.070
Identities = 37/146 (25%), Positives = 64/146 (43%), Gaps = 3/146 (2%)
Query: 29 DPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVL 88
D + + + D +A ++ LLER A + L+ A G ++L
Sbjct: 825 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 884
Query: 89 LRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATG 148
L +GA++ + T T L +A + ++VELL+ GA N+ R + L AA+G
Sbjct: 885 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGA--NKEHRNVSDYTPLSLAASG 942
Query: 149 CRSTILRTFVSYWKEGQTSRPPPKMG 174
I++ ++ E SR K+G
Sbjct: 943 GYVNIIKILLNAGAE-INSRTGSKLG 967
Score = 31.6 bits (70), Expect = 0.46
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 55 LLERKA--HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVL 112
LL++ A ++P AL A+ G + ++L+ GA+++ + T L +A
Sbjct: 1053 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAAN 1111
Query: 113 RNQPDMVELLVHHGADVNRRDREKL 137
D+V+LLV GADV+ D K+
Sbjct: 1112 GGHLDVVQLLVQAGADVDAADNRKI 1136
Score = 28.5 bits (62), Expect = 3.9
Identities = 27/110 (24%), Positives = 43/110 (39%), Gaps = 1/110 (0%)
Query: 26 GIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAA 85
G + + + A + + V LL+ A + + L A G A
Sbjct: 424 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 483
Query: 86 DVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+L+ GA+L E YT L A +MV LL+ GA++N + E
Sbjct: 484 ALLIERGASLE-EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
>gi|239757009 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 48.9 bits (115), Expect = 3e-06
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK Y + L++
Sbjct: 58 GDLDALDKQHRTAL----HLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HG ++ D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLFHGENIEALDKD 165
>gi|239751523 PREDICTED: ankyrin repeat domain 20 family, member A5
[Homo sapiens]
Length = 823
Score = 48.9 bits (115), Expect = 3e-06
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK Y + L++
Sbjct: 58 GDLDALDKQHRTAL----HLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HG ++ D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLFHGENIEALDKD 165
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 47.4 bits (111), Expect = 8e-06
Identities = 29/97 (29%), Positives = 52/97 (53%), Gaps = 1/97 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P + A+ +R+ V+ LL A +G L G A++L+RHGA++N
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
D + +T LH A + + ++ +LL+ HGAD +++R+
Sbjct: 747 D-LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
Score = 43.1 bits (100), Expect = 2e-04
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 1/109 (0%)
Query: 20 AILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL 79
A+L L + P ++A+ +R+ ++ LL+ A +G L
Sbjct: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGAD 128
G ++LL+HGA +N D + +T LH A +N+ ++ LL+ HGAD
Sbjct: 413 GHYEVTELLLKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSHGAD 460
Score = 39.3 bits (90), Expect = 0.002
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 1/51 (1%)
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD 133
+ ++LLR GAN+N E + T LH+A R D++E+L HGA +N D
Sbjct: 539 QVTELLLRKGANVN-EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD 588
Score = 38.5 bits (88), Expect = 0.004
Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P + A+ R V+ LL+ A+ +G L G +LL GA+ N
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
D Y T LH A ++ + D+ +L+ HGAD N R+ +
Sbjct: 279 DNWNY-TPLHEAAIKGKIDVCIVLLQHGADPNIRNTD 314
Score = 35.8 bits (81), Expect = 0.024
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 2/78 (2%)
Query: 62 SPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-PVTYYTALHIAVLRNQPDMVE 120
+P V LL+ ++ G L N+N D + T LH A N+ +VE
Sbjct: 643 TPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
Query: 121 LLVHHGADVNRRDREKLL 138
L+HHGADV+ +D+ L+
Sbjct: 702 YLLHHGADVHAKDKGGLV 719
Score = 35.0 bits (79), Expect = 0.041
Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 3/44 (6%)
Query: 95 LNFEDPVTYYTALHIAVLRNQP---DMVELLVHHGADVNRRDRE 135
+NF+ P ++ TALH AV P + ELL+ GA+VN ++++
Sbjct: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKD 557
Score = 34.7 bits (78), Expect = 0.054
Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A+ + + V LLE A +G L A G A +L+++ +N
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT 899
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
D + T LH A + + + LL+ HGAD +++E
Sbjct: 900 DKWAF-TPLHEAAQKGRTQLCALLLAHGADPTMKNQE 935
Score = 33.5 bits (75), Expect = 0.12
Identities = 15/34 (44%), Positives = 22/34 (64%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDREKLL 138
T LH+A N ++ E L+ HGADVN +D+ L+
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
Score = 33.1 bits (74), Expect = 0.16
Identities = 15/34 (44%), Positives = 24/34 (70%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDREKLL 138
T LH+A N+ +V+LL+ HGADV+ +D+ L+
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLV 404
Score = 32.7 bits (73), Expect = 0.20
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 3/91 (3%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
+ E +++ L L H+ ++ S L A R +LL+HGA+++ +D
Sbjct: 345 SGNEEKLMALLTPLNVNCHASDGRK--STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRD 133
LH A ++ ELL+ HGA VN D
Sbjct: 403 L-VPLHNACSYGHYEVTELLLKHGACVNAMD 432
Score = 32.7 bits (73), Expect = 0.20
Identities = 30/88 (34%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 42 VASEESRILVLTELLERK-AHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
VAS + +TELL RK A+ + L AE +VL +HGA +N D
Sbjct: 530 VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDT 589
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGAD 128
+ TALH A L LL+ +G+D
Sbjct: 590 LGQ-TALHRAALAGHLQTCRLLLSYGSD 616
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 47.4 bits (111), Expect = 8e-06
Identities = 32/112 (28%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 24 SLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTR 83
S+ +D E ++S P + A+ +R+ V+ LL+ A +G L G
Sbjct: 516 SVNCRDIEGRQST--PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYE 573
Query: 84 AADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A++L++HGA +N D + +T LH A + + ++ +LL+ HGAD +++R+
Sbjct: 574 VAELLVKHGAVVNVAD-LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRD 624
Score = 42.0 bits (97), Expect = 3e-04
Identities = 33/112 (29%), Positives = 52/112 (46%), Gaps = 7/112 (6%)
Query: 30 PERQESLDR------PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTR 83
PE+ S D P + A+ R V+ LL+ A+ +G L G
Sbjct: 46 PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105
Query: 84 AADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
++LLRHGA+ N D YT LH A ++ + D+ +L+ HGA+ R+ +
Sbjct: 106 VVNLLLRHGADPNARDNWN-YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTD 156
Score = 39.7 bits (91), Expect = 0.002
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 1/109 (0%)
Query: 20 AILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL 79
A+L L + P ++A+ +R+ ++ LL+ A +G L
Sbjct: 195 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSY 254
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGAD 128
G ++L++HGA +N D + +T LH A +N+ ++ LL+ +GAD
Sbjct: 255 GHYEVTELLVKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Score = 38.5 bits (88), Expect = 0.004
Identities = 21/48 (43%), Positives = 30/48 (62%), Gaps = 1/48 (2%)
Query: 86 DVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD 133
++LLR GAN+N E + T LH+A + D+VE++V H A VN D
Sbjct: 384 ELLLRKGANIN-EKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALD 430
Score = 35.0 bits (79), Expect = 0.041
Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 1/97 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A+ + + V LL+ A +G L A G A +L+++ A +N
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
D + T LH A + + + LL+ HGAD +++E
Sbjct: 742 DKWAF-TPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Score = 34.3 bits (77), Expect = 0.070
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 3/46 (6%)
Query: 95 LNFEDPVTYYTALHIAVLRNQP---DMVELLVHHGADVNRRDREKL 137
+NF+ P T+ TALH A P + ELL+ GA++N + +E L
Sbjct: 356 VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFL 401
Score = 33.9 bits (76), Expect = 0.092
Identities = 15/34 (44%), Positives = 24/34 (70%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDREKLL 138
T LH+A N+ +V+LL+ HGADV+ +D+ L+
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246
Score = 33.9 bits (76), Expect = 0.092
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 1/46 (2%)
Query: 94 NLNFEDPV-TYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLL 138
N+N D + T LH+A N ++ E L+ HGADVN +D+ L+
Sbjct: 669 NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLI 714
Score = 33.1 bits (74), Expect = 0.16
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 5/118 (4%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
+ E +++ L L H+ ++ S L A + +LL+HGA+++ +D
Sbjct: 187 SGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSY 160
LH A ++ ELLV HGA VN D + + L AA+ R + +SY
Sbjct: 245 L-VPLHNACSYGHYEVTELLVKHGACVNAMDLWQF--TPLHEAASKNRVEVCSLLLSY 299
Score = 32.3 bits (72), Expect = 0.27
Identities = 15/34 (44%), Positives = 22/34 (64%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDREKLL 138
T LH A N+ +VE L+ HGADV+ +D+ L+
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 47.0 bits (110), Expect = 1e-05
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 53 TELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAV 111
TE+L R S + V L MA G +VLL+HGA++N +D + TALH A
Sbjct: 54 TEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM-TALHWAT 112
Query: 112 LRNQPDMVELLVHHGADVNRRDR 134
N ++VELL+ +GADV+ + +
Sbjct: 113 EHNHQEVVELLIKYGADVHTQSK 135
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 62 SPFYQEGVSNALLKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
+PF + + + L +A + G +VLLR G + + V T LH+A +VE
Sbjct: 30 APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR-TPLHMAASEGHASIVE 88
Query: 121 LLVHHGADVNRRDREKL 137
+L+ HGADVN +D K+
Sbjct: 89 VLLKHGADVNAKDMLKM 105
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 47.0 bits (110), Expect = 1e-05
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 53 TELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAV 111
TE+L R S + V L MA G +VLL+HGA++N +D + TALH A
Sbjct: 54 TEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM-TALHWAT 112
Query: 112 LRNQPDMVELLVHHGADVNRRDR 134
N ++VELL+ +GADV+ + +
Sbjct: 113 EHNHQEVVELLIKYGADVHTQSK 135
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 62 SPFYQEGVSNALLKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
+PF + + + L +A + G +VLLR G + + V T LH+A +VE
Sbjct: 30 APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR-TPLHMAASEGHASIVE 88
Query: 121 LLVHHGADVNRRDREKL 137
+L+ HGADVN +D K+
Sbjct: 89 VLLKHGADVNAKDMLKM 105
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 47.0 bits (110), Expect = 1e-05
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 53 TELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAV 111
TE+L R S + V L MA G +VLL+HGA++N +D + TALH A
Sbjct: 54 TEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM-TALHWAT 112
Query: 112 LRNQPDMVELLVHHGADVNRRDR 134
N ++VELL+ +GADV+ + +
Sbjct: 113 EHNHQEVVELLIKYGADVHTQSK 135
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 62 SPFYQEGVSNALLKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
+PF + + + L +A + G +VLLR G + + V T LH+A +VE
Sbjct: 30 APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR-TPLHMAASEGHASIVE 88
Query: 121 LLVHHGADVNRRDREKL 137
+L+ HGADVN +D K+
Sbjct: 89 VLLKHGADVNAKDMLKM 105
>gi|8051597 GA binding protein transcription factor, beta subunit 1
isoform gamma 1 [Homo sapiens]
Length = 360
Score = 47.0 bits (110), Expect = 1e-05
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 53 TELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAV 111
TE+L R S + V L MA G +VLL+HGA++N +D + TALH A
Sbjct: 54 TEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM-TALHWAT 112
Query: 112 LRNQPDMVELLVHHGADVNRRDR 134
N ++VELL+ +GADV+ + +
Sbjct: 113 EHNHQEVVELLIKYGADVHTQSK 135
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 62 SPFYQEGVSNALLKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
+PF + + + L +A + G +VLLR G + + V T LH+A +VE
Sbjct: 30 APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR-TPLHMAASEGHASIVE 88
Query: 121 LLVHHGADVNRRDREKL 137
+L+ HGADVN +D K+
Sbjct: 89 VLLKHGADVNAKDMLKM 105
>gi|8051599 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 47.0 bits (110), Expect = 1e-05
Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 53 TELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAV 111
TE+L R S + V L MA G +VLL+HGA++N +D + TALH A
Sbjct: 54 TEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKM-TALHWAT 112
Query: 112 LRNQPDMVELLVHHGADVNRRDR 134
N ++VELL+ +GADV+ + +
Sbjct: 113 EHNHQEVVELLIKYGADVHTQSK 135
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 62 SPFYQEGVSNALLKMA-ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
+PF + + + L +A + G +VLLR G + + V T LH+A +VE
Sbjct: 30 APFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDR-TPLHMAASEGHASIVE 88
Query: 121 LLVHHGADVNRRDREKL 137
+L+ HGADVN +D K+
Sbjct: 89 VLLKHGADVNAKDMLKM 105
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 46.6 bits (109), Expect = 1e-05
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 1/98 (1%)
Query: 31 ERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLR 90
ER E P +A+E+ + ++ EL++ A+ AL+ ++ G + LL+
Sbjct: 33 ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLK 92
Query: 91 HGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGAD 128
G NL D + +TAL A + + D+VELL+ HGA+
Sbjct: 93 CGVNLEHRD-MGGWTALMWACYKGRTDVVELLLSHGAN 129
Score = 42.0 bits (97), Expect = 3e-04
Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 5/128 (3%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
AS+E + ++ ELL+ + G AL+ G T ++LL HGAN + +
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATG---CRSTILRTFVS 159
Y + A R D+V LL+ +GA VN D+ ++W A G C +L
Sbjct: 138 VYPIIWAAG-RGHADIVHLLLQNGAKVNCSDKYG-TTPLVWAARKGHLECVKHLLAMGAD 195
Query: 160 YWKEGQTS 167
+EG S
Sbjct: 196 VDQEGANS 203
Score = 36.2 bits (82), Expect = 0.019
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 3/116 (2%)
Query: 45 EESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYY 104
EE I L LLE+ E L+ AE G L+++GAN N ED + +
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLED-LDNW 72
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTILRTFVSY 160
TAL A +VE L+ G ++ RD +++W G R+ ++ +S+
Sbjct: 73 TALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKG-RTDVVELLLSH 126
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 46.2 bits (108), Expect = 2e-05
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK + L++
Sbjct: 58 GDLDALDKQHRTAL----HLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HGA + D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKD 165
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 46.2 bits (108), Expect = 2e-05
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK + L++
Sbjct: 58 GDLDALDKQHRTAL----HLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HGA + D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKD 165
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 46.2 bits (108), Expect = 2e-05
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK + L++
Sbjct: 58 GDLDALDKQHRTAL----HLACTSGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HGA + D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKD 165
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 46.2 bits (108), Expect = 2e-05
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
G L D + + +L ++A + V+T L+ RK + L++
Sbjct: 58 GELDALDKQHRTAL----HLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEE 113
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
A +LL HGAN N +D + TALH AV + E L+ HGA + D++
Sbjct: 114 ACAVILLEHGANPNLKD-IYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKD 165
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 45.8 bits (107), Expect = 2e-05
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 9/129 (6%)
Query: 10 IIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGV 69
+I + +A+LG+ G R + P ++A E+ L +L + +P +
Sbjct: 119 VITNQPEIAEALLGA-GCDPELRDFRGNTPLHLACEQG-CLASVGVLTQSCTTPHLHSIL 176
Query: 70 S------NALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELL 122
+ L +A + G ++L+ GA++N ++P TALH+AV PD+V LL
Sbjct: 177 KATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLL 236
Query: 123 VHHGADVNR 131
+ GADVNR
Sbjct: 237 LKCGADVNR 245
Score = 34.3 bits (77), Expect = 0.070
Identities = 18/41 (43%), Positives = 26/41 (63%), Gaps = 1/41 (2%)
Query: 93 ANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD 133
A LNF++ + T LH+AV+ NQP++ E L+ G D RD
Sbjct: 102 AFLNFQNNLQQ-TPLHLAVITNQPEIAEALLGAGCDPELRD 141
Score = 30.0 bits (66), Expect = 1.3
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 104 YTALHIAVLRNQPDMVELLVHHGADVNRRD 133
+T LH+A + +VELLV GADVN ++
Sbjct: 184 HTCLHLASIHGYLGIVELLVSLGADVNAQE 213
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 45.1 bits (105), Expect = 4e-05
Identities = 36/113 (31%), Positives = 52/113 (46%), Gaps = 5/113 (4%)
Query: 23 GSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
GS D R+ +L R AS E + +L +LL+ A F A+ G
Sbjct: 172 GSADTCDQFRRTALHR----ASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHL 227
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+L HGA+ N D + T LH+AV Q ++VE + G ++N RDRE
Sbjct: 228 EVVKLLQSHGADTNVRDKLLS-TPLHVAVRTGQVEIVEHFLSLGLEINARDRE 279
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 44.7 bits (104), Expect = 5e-05
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A++ L L +LL+ + AL A + +L HGA++N +D
Sbjct: 93 HLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKD- 151
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTI 153
V T L +A ++P + +LL+ GADVN RD++ ML GCR +
Sbjct: 152 VDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML-GCEYGCRDAV 203
Score = 34.7 bits (78), Expect = 0.054
Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
NAL A+ G LL++ D + TALH A + + P ++LL HGA VN
Sbjct: 90 NALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTALHDAAMADCPSSIQLLCDHGASVN 148
Query: 131 RRD 133
+D
Sbjct: 149 AKD 151
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 44.7 bits (104), Expect = 5e-05
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A++ L L +LL+ + AL A + +L HGA++N +D
Sbjct: 106 HLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKD- 164
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLCSMLWPAATGCRSTI 153
V T L +A ++P + +LL+ GADVN RD++ ML GCR +
Sbjct: 165 VDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALML-GCEYGCRDAV 216
Score = 34.7 bits (78), Expect = 0.054
Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
NAL A+ G LL++ D + TALH A + + P ++LL HGA VN
Sbjct: 103 NALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTALHDAAMADCPSSIQLLCDHGASVN 161
Query: 131 RRD 133
+D
Sbjct: 162 AKD 164
>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
Length = 282
Score = 43.9 bits (102), Expect = 9e-05
Identities = 41/135 (30%), Positives = 66/135 (48%), Gaps = 8/135 (5%)
Query: 21 ILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA-EL 79
++ SL ++ R+E D+ + E+ I +T+ ++ K ++ ALL A +
Sbjct: 145 VISSLYHEETIREE--DKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDR 202
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDREKLLC 139
G VLL+H A++N +D TALH A D+VELL+ GAD RD++
Sbjct: 203 GHKELVTVLLQHRADINCQDNEGQ-TALHYASACEFLDIVELLLQSGADPTLRDQD---- 257
Query: 140 SMLWPAATGCRSTIL 154
L TGC++ L
Sbjct: 258 GCLPEEVTGCKTVSL 272
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 43.5 bits (101), Expect = 1e-04
Identities = 21/41 (51%), Positives = 29/41 (70%)
Query: 88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGAD 128
LL GAN+NF++ +T LH AV ++ D+VELL+ HGAD
Sbjct: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD 84
Score = 32.3 bits (72), Expect = 0.27
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 66 QEGVSNALLKMAELGLTRAADVLLRH-GANLNFEDPVTYYTALHIAVLRNQPDM---VEL 121
++G + AL+ AE G +LL GA++N D + +H + + D+ L
Sbjct: 165 RKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHL 224
Query: 122 LVHHGADVNRR 132
L+ HGADVN R
Sbjct: 225 LLDHGADVNVR 235
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A R+ V+T LL+RK L+K A +LL+ GAN N +D
Sbjct: 172 HLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKD- 230
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+ TALH AV + E L+ H A++ ++E
Sbjct: 231 IYGNTALHYAVYNEGTSLAERLLSHHANIEALNKE 265
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A R+ V+T LL+RK L+K A +LL+ GAN N +D
Sbjct: 201 HLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKD- 259
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+ TALH AV + E L+ H A++ ++E
Sbjct: 260 IYGNTALHYAVYNEGTSLAERLLSHHANIEALNKE 294
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A R+ V+T LL+RK L+K A +LL+ GAN N +D
Sbjct: 201 HLACAHGRVQVVTLLLDRKCQINICDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKD- 259
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRE 135
+ TALH AV + E L+ H A++ ++E
Sbjct: 260 IYGNTALHYAVYNEGTSLAERLLSHHANIEALNKE 294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,922,979
Number of Sequences: 37866
Number of extensions: 331308
Number of successful extensions: 1993
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 221
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 1029
Number of HSP's gapped (non-prelim): 852
length of query: 197
length of database: 18,247,518
effective HSP length: 97
effective length of query: 100
effective length of database: 14,574,516
effective search space: 1457451600
effective search space used: 1457451600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.