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Search of human proteins with 122937219
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937219 F-box protein 41 [Homo sapiens]
(936 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937219 F-box protein 41 [Homo sapiens] 1865 0.0
gi|40789306 zinc finger protein 365 isoform C [Homo sapiens] 135 2e-31
gi|40789310 zinc finger protein 365 isoform B [Homo sapiens] 135 2e-31
gi|148596972 zinc finger protein 365 isoform A [Homo sapiens] 135 2e-31
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 57 6e-08
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 54 5e-07
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 54 5e-07
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 54 5e-07
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 54 5e-07
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 54 5e-07
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 54 7e-07
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 54 9e-07
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 53 1e-06
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 53 1e-06
gi|110832843 TBP-associated factor 4 [Homo sapiens] 51 6e-06
gi|91208420 bassoon protein [Homo sapiens] 51 6e-06
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 51 6e-06
gi|149408126 nemo like kinase [Homo sapiens] 50 8e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 50 8e-06
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 50 1e-05
gi|150010604 kinesin family member 4B [Homo sapiens] 50 1e-05
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 50 1e-05
gi|150378549 tangerin [Homo sapiens] 50 1e-05
gi|4506467 radixin [Homo sapiens] 49 2e-05
gi|148746195 trichohyalin [Homo sapiens] 49 2e-05
gi|229577185 epidermal growth factor receptor pathway substrate ... 49 2e-05
gi|4503593 epidermal growth factor receptor pathway substrate 15... 49 2e-05
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 49 2e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 49 3e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 49 3e-05
>gi|122937219 F-box protein 41 [Homo sapiens]
Length = 936
Score = 1865 bits (4830), Expect = 0.0
Identities = 936/936 (100%), Positives = 936/936 (100%)
Query: 1 MTTGLSDQQVVCDLDHRAVEALLQAVRKRMAGASPAVPHERARLTGGAAAVEPACRGGGG 60
MTTGLSDQQVVCDLDHRAVEALLQAVRKRMAGASPAVPHERARLTGGAAAVEPACRGGGG
Sbjct: 1 MTTGLSDQQVVCDLDHRAVEALLQAVRKRMAGASPAVPHERARLTGGAAAVEPACRGGGG 60
Query: 61 AMASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAA 120
AMASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAA
Sbjct: 61 AMASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAA 120
Query: 121 AASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFP 180
AASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFP
Sbjct: 121 AASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFP 180
Query: 181 GDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGP 240
GDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGP
Sbjct: 181 GDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGP 240
Query: 241 CPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQA 300
CPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQA
Sbjct: 241 CPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQA 300
Query: 301 ELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSR 360
ELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSR
Sbjct: 301 ELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSR 360
Query: 361 KQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLG 420
KQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLG
Sbjct: 361 KQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLG 420
Query: 421 RGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDS 480
RGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDS
Sbjct: 421 RGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDS 480
Query: 481 DSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHST 540
DSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHST
Sbjct: 481 DSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHST 540
Query: 541 EGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSP 600
EGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSP
Sbjct: 541 EGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSP 600
Query: 601 SRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARV 660
SRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARV
Sbjct: 601 SRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARV 660
Query: 661 CSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNL 720
CSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNL
Sbjct: 661 CSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNL 720
Query: 721 LILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVA 780
LILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVA
Sbjct: 721 LILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVA 780
Query: 781 PLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVS 840
PLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVS
Sbjct: 781 PLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVS 840
Query: 841 EITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPS 900
EITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPS
Sbjct: 841 EITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPS 900
Query: 901 SPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC 936
SPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC
Sbjct: 901 SPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC 936
>gi|40789306 zinc finger protein 365 isoform C [Homo sapiens]
Length = 462
Score = 135 bits (340), Expect = 2e-31
Identities = 109/347 (31%), Positives = 158/347 (45%), Gaps = 72/347 (20%)
Query: 67 LPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFP 126
LP RCPRCG+H RFRSLSSLRAHLE+SH+YE +L+K S FP
Sbjct: 24 LPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTK-----------------CSLFP 66
Query: 127 LAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPA 186
+ + + E+ + Q P+ +L H H+ D P
Sbjct: 67 SLKDTDLVTS-----SELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSK------DRKPF 115
Query: 187 SLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPAS 246
+ E P+ + ++ A S GPG P S
Sbjct: 116 EVVAER---------------------PVSYVQTYTAMDLHADSLDGTRSGPGL---PTS 151
Query: 247 ASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKA 306
+ AS +E + R +E VDR +E+ ++ +L EL +K
Sbjct: 152 DTKAS-------FEAHVREKFNRMVE--AVDRTIEK-----------RIDKLTKELAQKT 191
Query: 307 AELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVV 366
AEL R +L ++K+E++ R L+RQVDV+VE++A L+Q L E+EL RK++EVV
Sbjct: 192 AELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVV 251
Query: 367 QIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGS 413
+ FL+ A +E K RLQ FIE LL+R + AE+QL+ S S
Sbjct: 252 TFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQAS 298
>gi|40789310 zinc finger protein 365 isoform B [Homo sapiens]
Length = 333
Score = 135 bits (340), Expect = 2e-31
Identities = 109/347 (31%), Positives = 158/347 (45%), Gaps = 72/347 (20%)
Query: 67 LPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFP 126
LP RCPRCG+H RFRSLSSLRAHLE+SH+YE +L+K S FP
Sbjct: 24 LPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTK-----------------CSLFP 66
Query: 127 LAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPA 186
+ + + E+ + Q P+ +L H H+ D P
Sbjct: 67 SLKDTDLVTS-----SELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSK------DRKPF 115
Query: 187 SLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPAS 246
+ E P+ + ++ A S GPG P S
Sbjct: 116 EVVAER---------------------PVSYVQTYTAMDLHADSLDGTRSGPGL---PTS 151
Query: 247 ASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKA 306
+ AS +E + R +E VDR +E+ ++ +L EL +K
Sbjct: 152 DTKAS-------FEAHVREKFNRMVE--AVDRTIEK-----------RIDKLTKELAQKT 191
Query: 307 AELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVV 366
AEL R +L ++K+E++ R L+RQVDV+VE++A L+Q L E+EL RK++EVV
Sbjct: 192 AELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVV 251
Query: 367 QIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGS 413
+ FL+ A +E K RLQ FIE LL+R + AE+QL+ S S
Sbjct: 252 TFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQAS 298
>gi|148596972 zinc finger protein 365 isoform A [Homo sapiens]
Length = 407
Score = 135 bits (340), Expect = 2e-31
Identities = 109/347 (31%), Positives = 158/347 (45%), Gaps = 72/347 (20%)
Query: 67 LPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFP 126
LP RCPRCG+H RFRSLSSLRAHLE+SH+YE +L+K S FP
Sbjct: 24 LPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTK-----------------CSLFP 66
Query: 127 LAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPA 186
+ + + E+ + Q P+ +L H H+ D P
Sbjct: 67 SLKDTDLVTS-----SELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSK------DRKPF 115
Query: 187 SLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPAS 246
+ E P+ + ++ A S GPG P S
Sbjct: 116 EVVAER---------------------PVSYVQTYTAMDLHADSLDGTRSGPGL---PTS 151
Query: 247 ASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKA 306
+ AS +E + R +E VDR +E+ ++ +L EL +K
Sbjct: 152 DTKAS-------FEAHVREKFNRMVE--AVDRTIEK-----------RIDKLTKELAQKT 191
Query: 307 AELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVV 366
AEL R +L ++K+E++ R L+RQVDV+VE++A L+Q L E+EL RK++EVV
Sbjct: 192 AELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVV 251
Query: 367 QIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGS 413
+ FL+ A +E K RLQ FIE LL+R + AE+QL+ S S
Sbjct: 252 TFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQAS 298
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/237 (26%), Positives = 99/237 (41%), Gaps = 27/237 (11%)
Query: 220 ARKSVASSACSTPPPGPGPGPCPGPASASPASPSP-----ADVAYEEG----------LA 264
A ++A + S P P P P P P A ++PS A V G LA
Sbjct: 425 AAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLA 484
Query: 265 RLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKE 324
+ A E+ E + R R EE+E++ ++ + AE ER E +R+ A REKE
Sbjct: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAE-ERTTRREEESRRLEAEQAREKE 543
Query: 325 E-LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAK 383
E L+ +A E + + E K++ +E R +QE ++ RE +
Sbjct: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE-------REKHFQREEQER 596
Query: 384 LRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGP---NARGPGR 437
L ++ +EE+++R R E + S + GG A P NA G G+
Sbjct: 597 LERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGK 653
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/201 (25%), Positives = 91/201 (45%), Gaps = 28/201 (13%)
Query: 224 VASSACSTPPPGPGPGPC-PGPASASPAS--PSPADVAYEEGLARLKIRALEKLEVDRRL 280
++SS STP P P P P SP + P P+ EEGL R ++R LE+ RL
Sbjct: 44 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL-RAQVRDLEEKLETLRL 102
Query: 281 ERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVS 340
+R ++ + K ELE+ +LE ++ +++ ++ +L+ R E ++ +
Sbjct: 103 KRAEDKAKLK----------ELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEA 152
Query: 341 VELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRA 400
+E +++ + E+ +D+ + E A LQQ +E L ER D
Sbjct: 153 LEAKERYMEEMADTADAI-----EMATLDKEMAEERAES------LQQEVEALKERVDEL 201
Query: 401 ERQLQVISSSC---GSTPSAS 418
L+++ + GS +AS
Sbjct: 202 TTDLEILKAEIEEKGSDGAAS 222
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/135 (28%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
+++ L+K + R E L +EVE + +V L +LE AE+E + A + ++
Sbjct: 170 IEMATLDKEMAEERAESLQQEVEA-LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ 228
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
LEE+ + L + +L +S KQ+ V ++ + +K QE+ + Q +E E S +
Sbjct: 229 LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQ-QRERLQEELS---Q 284
Query: 386 LQQFIEELLERADRA 400
+ I+EL E+ D A
Sbjct: 285 AESTIDELKEQVDAA 299
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 17/152 (11%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE ARLK + R+ LS +Q+ +LQ +E+K ELE RQ+ RL
Sbjct: 230 EEQNARLKDALV-------RMRDLSSSEKQEHV----KLQKLMEKKNQELEVVRQQRERL 278
Query: 320 GREKEELEERASELSRQVDVS------VELLASLKQDLVHKEQELSRKQQEVVQIDQFLK 373
E + E EL QVD + VE+L +L K +EL ++ +++
Sbjct: 279 QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND 338
Query: 374 ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
E +L L++ ++ R A+++++
Sbjct: 339 ELQENARETELELREQLDMAGARVREAQKRVE 370
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/201 (25%), Positives = 91/201 (45%), Gaps = 28/201 (13%)
Query: 224 VASSACSTPPPGPGPGPC-PGPASASPAS--PSPADVAYEEGLARLKIRALEKLEVDRRL 280
++SS STP P P P P SP + P P+ EEGL R ++R LE+ RL
Sbjct: 158 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL-RAQVRDLEEKLETLRL 216
Query: 281 ERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVS 340
+R ++ + K ELE+ +LE ++ +++ ++ +L+ R E ++ +
Sbjct: 217 KRAEDKAKLK----------ELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEA 266
Query: 341 VELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRA 400
+E +++ + E+ +D+ + E A LQQ +E L ER D
Sbjct: 267 LEAKERYMEEMADTADAI-----EMATLDKEMAEERAES------LQQEVEALKERVDEL 315
Query: 401 ERQLQVISSSC---GSTPSAS 418
L+++ + GS +AS
Sbjct: 316 TTDLEILKAEIEEKGSDGAAS 336
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/135 (28%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
+++ L+K + R E L +EVE + +V L +LE AE+E + A + ++
Sbjct: 284 IEMATLDKEMAEERAESLQQEVEA-LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ 342
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
LEE+ + L + +L +S KQ+ V ++ + +K QE+ + Q +E E S +
Sbjct: 343 LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQ-QRERLQEELS---Q 398
Query: 386 LQQFIEELLERADRA 400
+ I+EL E+ D A
Sbjct: 399 AESTIDELKEQVDAA 413
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 17/152 (11%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE ARLK + R+ LS +Q+ +LQ +E+K ELE RQ+ RL
Sbjct: 344 EEQNARLKDALV-------RMRDLSSSEKQEHV----KLQKLMEKKNQELEVVRQQRERL 392
Query: 320 GREKEELEERASELSRQVDVS------VELLASLKQDLVHKEQELSRKQQEVVQIDQFLK 373
E + E EL QVD + VE+L +L K +EL ++ +++
Sbjct: 393 QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND 452
Query: 374 ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
E +L L++ ++ R A+++++
Sbjct: 453 ELQENARETELELREQLDMAGARVREAQKRVE 484
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/201 (25%), Positives = 91/201 (45%), Gaps = 28/201 (13%)
Query: 224 VASSACSTPPPGPGPGPC-PGPASASPAS--PSPADVAYEEGLARLKIRALEKLEVDRRL 280
++SS STP P P P P SP + P P+ EEGL R ++R LE+ RL
Sbjct: 44 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL-RAQVRDLEEKLETLRL 102
Query: 281 ERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVS 340
+R ++ + K ELE+ +LE ++ +++ ++ +L+ R E ++ +
Sbjct: 103 KRAEDKAKLK----------ELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEA 152
Query: 341 VELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRA 400
+E +++ + E+ +D+ + E A LQQ +E L ER D
Sbjct: 153 LEAKERYMEEMADTADAI-----EMATLDKEMAEERAES------LQQEVEALKERVDEL 201
Query: 401 ERQLQVISSSC---GSTPSAS 418
L+++ + GS +AS
Sbjct: 202 TTDLEILKAEIEEKGSDGAAS 222
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/135 (28%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
+++ L+K + R E L +EVE + +V L +LE AE+E + A + ++
Sbjct: 170 IEMATLDKEMAEERAESLQQEVEA-LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ 228
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
LEE+ + L + +L +S KQ+ V ++ + +K QE+ + Q +E E S +
Sbjct: 229 LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQ-QRERLQEELS---Q 284
Query: 386 LQQFIEELLERADRA 400
+ I+EL E+ D A
Sbjct: 285 AESTIDELKEQVDAA 299
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 17/152 (11%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE ARLK + R+ LS +Q+ +LQ +E+K ELE RQ+ RL
Sbjct: 230 EEQNARLKDALV-------RMRDLSSSEKQEHV----KLQKLMEKKNQELEVVRQQRERL 278
Query: 320 GREKEELEERASELSRQVDVS------VELLASLKQDLVHKEQELSRKQQEVVQIDQFLK 373
E + E EL QVD + VE+L +L K +EL ++ +++
Sbjct: 279 QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND 338
Query: 374 ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
E +L L++ ++ R A+++++
Sbjct: 339 ELQENARETELELREQLDMAGARVREAQKRVE 370
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/201 (25%), Positives = 91/201 (45%), Gaps = 28/201 (13%)
Query: 224 VASSACSTPPPGPGPGPC-PGPASASPAS--PSPADVAYEEGLARLKIRALEKLEVDRRL 280
++SS STP P P P P SP + P P+ EEGL R ++R LE+ RL
Sbjct: 178 LSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL-RAQVRDLEEKLETLRL 236
Query: 281 ERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVS 340
+R ++ + K ELE+ +LE ++ +++ ++ +L+ R E ++ +
Sbjct: 237 KRAEDKAKLK----------ELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEA 286
Query: 341 VELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRA 400
+E +++ + E+ +D+ + E A LQQ +E L ER D
Sbjct: 287 LEAKERYMEEMADTADAI-----EMATLDKEMAEERAES------LQQEVEALKERVDEL 335
Query: 401 ERQLQVISSSC---GSTPSAS 418
L+++ + GS +AS
Sbjct: 336 TTDLEILKAEIEEKGSDGAAS 356
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/135 (28%), Positives = 69/135 (51%), Gaps = 5/135 (3%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
+++ L+K + R E L +EVE + +V L +LE AE+E + A + ++
Sbjct: 304 IEMATLDKEMAEERAESLQQEVEA-LKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQ 362
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
LEE+ + L + +L +S KQ+ V ++ + +K QE+ + Q +E E S +
Sbjct: 363 LEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQ-QRERLQEELS---Q 418
Query: 386 LQQFIEELLERADRA 400
+ I+EL E+ D A
Sbjct: 419 AESTIDELKEQVDAA 433
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/152 (26%), Positives = 68/152 (44%), Gaps = 17/152 (11%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE ARLK + R+ LS +Q+ +LQ +E+K ELE RQ+ RL
Sbjct: 364 EEQNARLKDALV-------RMRDLSSSEKQEHV----KLQKLMEKKNQELEVVRQQRERL 412
Query: 320 GREKEELEERASELSRQVDVS------VELLASLKQDLVHKEQELSRKQQEVVQIDQFLK 373
E + E EL QVD + VE+L +L K +EL ++ +++
Sbjct: 413 QEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMND 472
Query: 374 ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
E +L L++ ++ R A+++++
Sbjct: 473 ELQENARETELELREQLDMAGARVREAQKRVE 504
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 54.3 bits (129), Expect = 5e-07
Identities = 78/294 (26%), Positives = 119/294 (40%), Gaps = 43/294 (14%)
Query: 247 ASPASPSPADVAYEEGLARLKIRALEKLEVDRRL-----------ERLSEEVEQ--KIAG 293
A+ A+P YE GL L RA + L + R ERL +++ +I G
Sbjct: 2141 AAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPG 2200
Query: 294 QV--GRLQAELERKAAELET-ARQESARLGREKEELEERASELSRQVDVSVELLASLKQD 350
+V L A E A T A E R E++E +RA EL R+ +Q+
Sbjct: 2201 RVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPE-------RQE 2253
Query: 351 LVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSS 410
V + +E +R+++ Q E+A EA+ L L ++ E++ R +R ER+L+ SS
Sbjct: 2254 SVDQSEEAARRRRPERQ------ESAEHEAAHSLTLGRY-EQMERRRERRERRLERQESS 2306
Query: 411 CGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSP------STGA 464
P RG G A +++E GP +P ++ + P
Sbjct: 2307 EQEMPI----RGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLEL 2362
Query: 465 SSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPP 518
R P + PRP EG G G +R+ A GGS + PP
Sbjct: 2363 PERTPRPDRPRARDRPKPRRRPRPREGG---EGGGSRRSRSAPAQGGSAPAPPP 2413
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 53.9 bits (128), Expect = 7e-07
Identities = 63/250 (25%), Positives = 103/250 (41%), Gaps = 30/250 (12%)
Query: 618 LFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHS 677
L IF++LD TL A++ + W +A + W R+ L N ++
Sbjct: 20 LLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQI-------------DVEG 66
Query: 678 LTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGG--NLLILRISHCPNILTDR 735
++N+ R G S RGC+ G SL A N+ L ++ C I TD
Sbjct: 67 RVVENISKRCGGFLRK-----LSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKI-TDS 120
Query: 736 SLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRC 795
+ + S +C L+ + S + + + + GCR +L+ L C Q T+
Sbjct: 121 TCYSLSRFCSKLKHLDLTSCVS-ITNSSLKGISEGCR---NLEYLNLSWCDQITKDG--- 173
Query: 796 LQMIGRCWPHLRALGVGG-AGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREG 854
++ + R L+AL + G + L + C L L L S IT E ++CR G
Sbjct: 174 IEALVRGCRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICR-G 232
Query: 855 LKGLEMLVLT 864
L+ L L+
Sbjct: 233 CHRLQALCLS 242
Score = 37.0 bits (84), Expect = 0.086
Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 1/85 (1%)
Query: 801 RCWPHLRALGVGGA-GCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLE 859
RC LR L + G G G L + A+NC ++ L L+ ++IT + R K
Sbjct: 75 RCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKH 134
Query: 860 MLVLTATPVTPKALLHFNSICRNLK 884
+ + + +T +L + CRNL+
Sbjct: 135 LDLTSCVSITNSSLKGISEGCRNLE 159
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 53.5 bits (127), Expect = 9e-07
Identities = 42/155 (27%), Positives = 78/155 (50%), Gaps = 8/155 (5%)
Query: 259 YEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESAR 318
+EE L + R E+ E R E E E+++ Q RL+ + ER + E R++ R
Sbjct: 253 HEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEER 312
Query: 319 LGREKEELEERASELSRQVDVS------VELLASLKQDLVHKEQE-LSRKQQEVVQIDQF 371
L ++E L E+ L Q + E+ L+Q+ +EQE L +++ + ++++
Sbjct: 313 LCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEEL 372
Query: 372 LKETAAREASAKLRLQQFIEELLERADRAERQLQV 406
L++ R+ +L Q+ ++EL ER ER L++
Sbjct: 373 LEQERLRQQDERLWQQETLQEL-ERLRELERMLEL 406
Score = 48.5 bits (114), Expect = 3e-05
Identities = 48/174 (27%), Positives = 76/174 (43%), Gaps = 4/174 (2%)
Query: 269 RALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELE- 327
R LE++E ER EE E+ + + RL E+E + E E RQ+ RL +++ E
Sbjct: 338 RLLEEVEKLLEQERRQEEQERLLERE--RLLEEVE-ELLEQERLRQQDERLWQQETLQEL 394
Query: 328 ERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQ 387
ER EL R +++ E L + + +EL+ + + +Q++Q +KE + + R
Sbjct: 395 ERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGS 454
Query: 388 QFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGPNARGPGRMREH 441
+ A Q + G TP G GG G G A G G H
Sbjct: 455 ESAAAARPVAGAPVPQGAWMCGQAGWTPQEHPGLGGEAVGTGEAAGGAGEAACH 508
Score = 36.2 bits (82), Expect = 0.15
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 7/122 (5%)
Query: 289 QKIAGQVGRLQAELE----RKAAELETARQESARLGREKEEL---EERASELSRQVDVSV 341
+++ + L+ ELE + AE+E + S R++E L EER E ++
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQE 219
Query: 342 ELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAE 401
E L ++ L +E+ L +++ + + ++ L+E R + RL + E L E+ +R
Sbjct: 220 ERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLH 279
Query: 402 RQ 403
Q
Sbjct: 280 EQ 281
Score = 33.5 bits (75), Expect = 0.95
Identities = 31/140 (22%), Positives = 69/140 (49%), Gaps = 9/140 (6%)
Query: 267 KIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKE-- 324
+I ++KL R L +L + + +A + +++E+ E R+E +GR+ +
Sbjct: 126 EIHLVQKL--GRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAE 183
Query: 325 -ELEERASELSRQVDVSV----ELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAARE 379
E + S L+R+ + + E L ++ L +E+ L +++ + + ++ L+E R
Sbjct: 184 VENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERL 243
Query: 380 ASAKLRLQQFIEELLERADR 399
+ RL++ E L E+ +R
Sbjct: 244 CEQEERLREHEERLCEQEER 263
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 53.1 bits (126), Expect = 1e-06
Identities = 83/392 (21%), Positives = 147/392 (37%), Gaps = 51/392 (13%)
Query: 133 ALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEE 192
+L A P AR ++ K +A SP+ H P + P +LP +
Sbjct: 442 SLPASPRARLSASTASELSPKSKARPSSPSTSW-------HRPASPCPSPGPGHTLPPKP 494
Query: 193 LAEPGLVPAAAARYALRE-------IEIPLGELFARKSVASSACSTPPPGPGPGPCPGPA 245
+ G + R +E P + +++ ++ S P P P P P P
Sbjct: 495 PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPT 554
Query: 246 SASPASPSP-ADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELER 304
A P P A+ + + + + + ++ E RL AE R
Sbjct: 555 PAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT------RLLAEKRR 608
Query: 305 KAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQE 364
+A E ++ RL E+++ R +L+R+ + E A ++ + +E ++ +QE
Sbjct: 609 QAREQREREEQERRLQAERDK-RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQE 667
Query: 365 VVQIDQFLKETA---AREASAKLRLQQ---FIEELLERADRAERQLQVI----SSSCGST 414
+ Q KE A +RE + + RL++ F ++ ER +R +R +++ S T
Sbjct: 668 EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSET 727
Query: 415 PSASLGRGGGGGGAGP------NARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRV 468
+ G+ P AR PG +E AV + + P S+
Sbjct: 728 KQKQDSKEANANGSSPEPVKAVEARSPGLQKE-----AVQKEEPIPQ---EPQWSLPSKE 779
Query: 469 PAASQSSGCYDSDSLELPRPEEGAPEDSGPGG 500
AS +G LP +E +GP G
Sbjct: 780 LPASLVNGLQ-----PLPAHQENGFSTNGPSG 806
Score = 37.4 bits (85), Expect = 0.066
Identities = 99/468 (21%), Positives = 160/468 (34%), Gaps = 61/468 (13%)
Query: 196 PGLVPAAAARYALREIEIPLGELFAR------KSVASSACSTPPPGPGPGP--------- 240
P + A +++ E E P G++ R +S +S A S P P GP
Sbjct: 53 PAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRS 112
Query: 241 -CPGPASASPASPSPA------------DVAYEEGLARLKIRALEK---LEVDRRLERLS 284
P P +A PAS SP +A E R K A +K LE + + + L
Sbjct: 113 SQPSP-TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALR 171
Query: 285 EEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVE-- 342
E+ Q+ ++ + + E++ A LE +++ +E+ E + S ++ +
Sbjct: 172 EKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
Query: 343 -LLASLKQDLVHKEQELSRKQQEVV----QIDQFLKETAAREASA---------KLRLQQ 388
+L + SR V +D + + ++ ++ L+L
Sbjct: 232 SWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSA 291
Query: 389 FIEELLERADRAERQLQVISSSCGSTP--------SASLGRGGGGGGAGPN-ARGPGRMR 439
+ +++R S S + P GRG G AG + ARGP R
Sbjct: 292 WESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDR 351
Query: 440 EHHVG--PAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSG 497
H P P + + S T + R A + ++ P P PE S
Sbjct: 352 THPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASP 411
Query: 498 PGGLGTRAQAANGGSERSQPPRSSGL-RRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTE 556
+ + E+S R L +RQ++ R ST E S +
Sbjct: 412 VQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPS 471
Query: 557 SEAEGPLD-APRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSPSRS 603
+ P P PGP P GR RR E S S
Sbjct: 472 TSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPS 519
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 53.1 bits (126), Expect = 1e-06
Identities = 54/201 (26%), Positives = 82/201 (40%), Gaps = 22/201 (10%)
Query: 214 PLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPAD-------VAYEEGLARL 266
P GE K V S G A+ + D +A + ARL
Sbjct: 354 PQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARL 413
Query: 267 KIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEEL 326
+ E+ V++ + E E K + RL+ E E + E E RQE + +E EE
Sbjct: 414 QKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEK 473
Query: 327 EERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRL 386
+ E R+ + ELL KQ+ +E+ + KQ+E ET ARE + ++RL
Sbjct: 474 RKAGEEAKRKAEE--ELLLKEKQEQEKQEKAMIEKQKEAA-------ETKAREVAEQMRL 524
Query: 387 Q------QFIEELLERADRAE 401
+ Q +E LER R +
Sbjct: 525 EREQIMLQIEQERLERKKRID 545
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 50.8 bits (120), Expect = 6e-06
Identities = 55/155 (35%), Positives = 61/155 (39%), Gaps = 41/155 (26%)
Query: 113 AAAAAAAAAASGFP-LAPEPA-ALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHH 170
AA A AA A G P APEP A A PG G ++ PSP P
Sbjct: 70 AAGAGPAAPAEGAPGAAPEPPPAGRARPGGG----------GPQRPGPPSPRRP------ 113
Query: 171 HHHAPLAHFPGDLVPA--SLPCEELAEP--------GLVPAAAARYALREIEIPLGELFA 220
LVPA + P +L P VPAAAA A E P G
Sbjct: 114 ------------LVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPE-PAPAGPAKP 160
Query: 221 RKSVASSACSTPPPGPGPGPCPGPASASPASPSPA 255
A +A + P PGPGPGP PGP PA P A
Sbjct: 161 AGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAA 195
Score = 49.7 bits (117), Expect = 1e-05
Identities = 79/290 (27%), Positives = 99/290 (34%), Gaps = 47/290 (16%)
Query: 7 DQQVVCDLDHRAVEALLQAVRKRMAGASPAVPHERARLTG------------GAAAVEPA 54
D++VV DL ++E+ L A +P P RA G GAA PA
Sbjct: 18 DEKVVSDLVG-SLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPA 76
Query: 55 CRGGGGAMASLDLP---YRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDG 111
G A+ + P P G +R S R + +
Sbjct: 77 APAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGS 136
Query: 112 AAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPH------ 165
A AAAA A+G AP A A P A G GP P P
Sbjct: 137 CAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQ 196
Query: 166 -------LLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLV------PAAAARYALREIE 212
LL+ HH AP + A LP + A PG V AAA A
Sbjct: 197 TLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPS 256
Query: 213 IPLGELFARKSVASSACSTPPPGPGP-------GPCPGPASASPASPSPA 255
P A + A+ A + PPP P P G GP +A+PA P PA
Sbjct: 257 PP-----AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPA 301
Score = 37.0 bits (84), Expect = 0.086
Identities = 46/161 (28%), Positives = 57/161 (35%), Gaps = 33/161 (20%)
Query: 441 HHVGPAVPNTYAVSRHG------SSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPE 494
HH+ P P A + S GA+ PAA P EGAP
Sbjct: 41 HHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAA----------------PAEGAPG 84
Query: 495 DSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPR---RHSTEGEEGDVSDVG 551
+ RA+ GG +R PP RR + P R EG G + V
Sbjct: 85 AAPEPPPAGRARPGGGGPQRPGPPSP---RRPLVPAGPAPPAAKLRPPPEGSAGSCAPVP 141
Query: 552 SRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRG 592
+ + A GP AP GPA P L+AR G G G
Sbjct: 142 A--AAAVAAGPEPAP-AGPAK--PAGPAALAARAGPGPGPG 177
Score = 31.2 bits (69), Expect = 4.7
Identities = 33/99 (33%), Positives = 39/99 (39%), Gaps = 16/99 (16%)
Query: 415 PSASLGRGGGGGGAGPNARGPGRMREHHV--GPAVPNTYAVSRHGSSPSTGASSRVPAAS 472
P A R GGGG P GP R V GPA P A R S G+ + VPAA+
Sbjct: 90 PPAGRARPGGGG---PQRPGPPSPRRPLVPAGPAPP--AAKLRPPPEGSAGSCAPVPAAA 144
Query: 473 QSSGCYDSDSLELPRPEEGAP-EDSGPGGLGTRAQAANG 510
+ P P P + +GP L RA G
Sbjct: 145 AVAAG--------PEPAPAGPAKPAGPAALAARAGPGPG 175
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 50.8 bits (120), Expect = 6e-06
Identities = 89/338 (26%), Positives = 138/338 (40%), Gaps = 53/338 (15%)
Query: 110 DGAAAAAAAAAAASGFPLAPEPAALLA--VPGARREVFES--------TSFQGKEQAAGP 159
DG + A+ P+ +PA++L V G + S TS A
Sbjct: 2191 DGMIYSTINTPIAATLPITTQPASVLRPMVRGGMYRPYASGGITAVPLTSLTRVPMIAPR 2250
Query: 160 SPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEE----LAEPGLVPAAAARYALREIEIPL 215
P P L+ + AP + FP + +S+P E L +P A A R E+P+
Sbjct: 2251 VPLGPTGLYRYP--AP-SRFP---IASSVPPAEGPVYLGKPAAAKAPGAGGPSRP-EMPV 2303
Query: 216 GELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLE 275
G AR+ + +TP P PA + P PAD A G L EK E
Sbjct: 2304 GA--AREEPLPT--TTPAAIKEAAGAPAPAPLAGQKP-PADAAPGGGSGALSRPGFEKEE 2358
Query: 276 VDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSR 335
+ ER ++ EQ + +LER+ ELE RQ R +EELE EL R
Sbjct: 2359 ASQE-ERQRKQQEQLL---------QLERERVELEKLRQL-----RLQEELERERVELQR 2403
Query: 336 Q-------VDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQ 388
V ++ L ++K ++ ++QE R+ Q +Q +Q ++ E +L+ QQ
Sbjct: 2404 HREEEQLLVQRELQELQTIKHHVLQQQQE-ERQAQFALQREQLAQQRLQLEQIQQLQ-QQ 2461
Query: 389 FIEELLERADRAERQLQVISSSCGSTP---SASLGRGG 423
++L E+ R + + G P +A L + G
Sbjct: 2462 LQQQLEEQKQRQKAPFPAACEAPGRGPPLAAAELAQNG 2499
Score = 36.6 bits (83), Expect = 0.11
Identities = 96/408 (23%), Positives = 147/408 (36%), Gaps = 55/408 (13%)
Query: 216 GELFARKSVASSACS-TPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKL 274
G+L A + S+A P PGPGPGP PGP S S + +E L + +
Sbjct: 44 GQLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTS------RRLDPKEPLGNQRAASPTPK 97
Query: 275 EVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELS 334
+ E + G G+ +A+ R+ ++++ Q S GR +R S +
Sbjct: 98 QASATTPGHESPRETRAQGPAGQ-EADGPRRTLQVDSRTQRS---GRSPSVSPDRGSTPT 153
Query: 335 RQVDV----------------SVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAR 378
V + +L ++ Q + + K + T +
Sbjct: 154 SPYSVPQIAPLPSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVK 213
Query: 379 E-ASAKLRLQQFIEELLERADRAERQLQVIS---SSCGSTPSASLGRGGGGGGAGPNARG 434
E ++Q+ + + A R++ Q Q+ S S S LG+ GP
Sbjct: 214 EWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSRGPGGPQ 273
Query: 435 PG-RMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEG-A 492
PG R E +VP ++ + P G S P S PRP G A
Sbjct: 274 PGSRQAETARATSVPGP---AQAAAPPEVGRVSPQPPQP------TKPSTAEPRPPAGEA 324
Query: 493 PEDSG---PGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGE----EG 545
P S P GLG Q G + + +S L QA +P T+G+ +G
Sbjct: 325 PAKSATAVPAGLGATEQTQEGLTGKLFGLGAS-LLTQASTLMSVQPEA-DTQGQPAPSKG 382
Query: 546 DVSDVGSRTTESEAEGPL-DAPRPGPAMAGPLSSCRLSARPEGGSGRG 592
V + ++ PL P PGPA P + AR GSG G
Sbjct: 383 TPKIVFNDASKEAGPKPLGSGPGPGPA---PGAKTEPGARMGPGSGPG 427
Score = 34.7 bits (78), Expect = 0.43
Identities = 44/177 (24%), Positives = 60/177 (33%), Gaps = 26/177 (14%)
Query: 418 SLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGA--SSRVPAASQSS 475
SL G G G P GPG G P + A + G P+ GA S+ VP
Sbjct: 6 SLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPS-APAGGGQLPAAGAARSTAVP------ 58
Query: 476 GCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANG-GSERSQPPRSSGLRRQAIQNWQRR 534
+P P G GPG R G++R+ P + A
Sbjct: 59 --------PVPGPGPGPGPGPGPGSTSRRLDPKEPLGNQRAASPTPK--QASATTPGHES 108
Query: 535 PRRHSTEGEEGDVSDVGSRT------TESEAEGPLDAPRPGPAMAGPLSSCRLSARP 585
PR +G G +D RT T+ P +P G P S +++ P
Sbjct: 109 PRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLP 165
Score = 31.6 bits (70), Expect = 3.6
Identities = 40/156 (25%), Positives = 55/156 (35%), Gaps = 19/156 (12%)
Query: 462 TGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSS 521
+GA+SR P Q + + + S P G+ A AA+ + + QP S+
Sbjct: 3769 SGAASRQPQTQQQQQGLGLQPPQQALTQARLQQQSQPTTRGS-APAASQPAGKPQPGPST 3827
Query: 522 GLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRL 581
Q PR T G +G + P P PGP AG +
Sbjct: 3828 ATGPQPAGP----PRAEQTNGSKGTAK------APQQGRAPQAQPAPGPGPAG----VKA 3873
Query: 582 SARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAA 617
ARP G G A P E + +IL AA
Sbjct: 3874 GARPGGTPG----APAGQPGADGESVFSKILPGGAA 3905
Score = 30.8 bits (68), Expect = 6.2
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 232 PPPGPGPGPCPGP---ASASPASPSPADVAYEEGLAR 265
PP G GPGP PGP A P++P+ G AR
Sbjct: 17 PPGGAGPGPGPGPGPGAGKPPSAPAGGGQLPAAGAAR 53
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 50.8 bits (120), Expect = 6e-06
Identities = 70/291 (24%), Positives = 114/291 (39%), Gaps = 30/291 (10%)
Query: 601 SRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARV 660
S S+E + + L + L IF++LD TL A+V R W +A + W R+
Sbjct: 17 SNSDEAVINKKLP-KELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI------- 68
Query: 661 CSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGG-- 718
L + ++N+ R G S RGCL G +L A
Sbjct: 69 ------DLFDFQRDIEGRVVENISKRCGGFLRK-----LSLRGCLGVGDNALRTFAQNCR 117
Query: 719 NLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQ 778
N+ +L ++ C TD + S +C L+ + S T + + + AL GC + L
Sbjct: 118 NIEVLNLNGCTK-TTDATCTSLSKFCSKLRHLDLASCTS-ITNMSLKALSEGCPLLEQLN 175
Query: 779 VAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGG-AGCGVQGLASLARNCMRLQVLELD 837
++ C Q T+ +Q + R L+AL + G + L + +C L L L
Sbjct: 176 IS---WCDQVTKDG---IQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229
Query: 838 HVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVV 888
+IT E +CR K + + +T L C L+ + V
Sbjct: 230 TCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEV 280
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 50.4 bits (119), Expect = 8e-06
Identities = 39/132 (29%), Positives = 55/132 (41%), Gaps = 21/132 (15%)
Query: 135 LAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELA 194
+++ GAR ++ G AA HHHHHH L H P P L
Sbjct: 1 MSLCGARANAKMMAAYNGGTSAAAAG-------HHHHHHHHLPHLP----PPHLHHHHHP 49
Query: 195 EPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPG--------PGPGPCPGPAS 246
+ L P +AA A+ ++ A + A++A + PG P PG PGPA+
Sbjct: 50 QHHLHPGSAA--AVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAA 107
Query: 247 ASPASPSPADVA 258
A+PA A A
Sbjct: 108 AAPAQVQAAAAA 119
Score = 34.3 bits (77), Expect = 0.56
Identities = 28/75 (37%), Positives = 35/75 (46%), Gaps = 23/75 (30%)
Query: 112 AAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLL---- 167
+AAAAAAAAAA AA + PG ++ F S + QA GP+ AAP +
Sbjct: 70 SAAAAAAAAAA---------AAAMLNPGQQQPYFPSPA---PGQAPGPAAAAPAQVQAAA 117
Query: 168 -------HHHHHHAP 175
HH H H P
Sbjct: 118 AATVKAHHHQHSHHP 132
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 50.4 bits (119), Expect = 8e-06
Identities = 42/145 (28%), Positives = 73/145 (50%), Gaps = 15/145 (10%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
+E ++L+ E E LE+ +EE+E GQ+ +L+A+ A E A Q+ +
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEELE----GQIKKLEADSLEVKASKEQALQDLQQQ 756
Query: 320 GREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELS------RKQQEVVQI----- 368
+ +LE RA+ELS+Q+++ E+++S + DL K + L KQ+E QI
Sbjct: 757 RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF 816
Query: 369 DQFLKETAAREASAKLRLQQFIEEL 393
+ +ET + R+Q + EL
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTEL 841
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/135 (25%), Positives = 62/135 (45%), Gaps = 8/135 (5%)
Query: 258 AYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESA 317
A E L R+ + EK E ++L+ EVE K L+AE ++ + E Q
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQ----HLKAEFKQLQQQREEKEQHGL 410
Query: 318 RLGREKEELEERASELSRQVDVSVELLASLKQ----DLVHKEQELSRKQQEVVQIDQFLK 373
+L E +L + E RQ+ + L +Q L+ KEQ+++ Q ++ ++++ LK
Sbjct: 411 QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 374 ETAAREASAKLRLQQ 388
E + +L +
Sbjct: 471 EKVTNSTELQHQLDK 485
Score = 35.8 bits (81), Expect = 0.19
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 27/127 (21%)
Query: 273 KLEVDRRLERL---------SEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREK 323
KLE++ E+L +E+ EQ++ G + L+ E+K ++E + E +K
Sbjct: 930 KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989
Query: 324 EELE------------------ERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEV 365
ELE E+ S L + S E L+ D +E EL +Q++
Sbjct: 990 TELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049
Query: 366 VQIDQFL 372
+++ L
Sbjct: 1050 KSVEEKL 1056
Score = 33.9 bits (76), Expect = 0.73
Identities = 34/159 (21%), Positives = 72/159 (45%), Gaps = 11/159 (6%)
Query: 264 ARLKIRALEKLEVDRRLERLS--EEVEQKIAGQVGRLQAELERKAAELETARQESARLGR 321
A LK E+ + LE+ ++ E K G V AEL+ +LE A+ E+ + +
Sbjct: 97 ASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQ 156
Query: 322 EKEELEERASELSRQV-------DVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKE 374
K+ E++A++L+ ++ D L + +Q + +EL+++ + + L +
Sbjct: 157 MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216
Query: 375 TAAREASAKLRLQQF-IEELLERAD-RAERQLQVISSSC 411
E A L+ + ++ L++ ER+ + + C
Sbjct: 217 RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDEC 255
Score = 33.9 bits (76), Expect = 0.73
Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 26/145 (17%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQ-ESARLGREKE 324
LKI L+K E++ +L++ + Q++A + ++ ET +Q +S GRE E
Sbjct: 982 LKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Query: 325 ELEERASELSRQVDVSV----------------ELLASLKQDLVHKEQELSRKQQEV--- 365
L R S + +S+ +L+ LK EQ+ ++K+Q++
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
Query: 366 ------VQIDQFLKETAAREASAKL 384
+Q ++ LKE +KL
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSKL 1126
Score = 32.7 bits (73), Expect = 1.6
Identities = 27/127 (21%), Positives = 60/127 (47%), Gaps = 6/127 (4%)
Query: 281 ERLSEEVEQKIAG--QVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVD 338
E+LS E I+ Q+G ++ T Q+SA+ ++ +E + ++ ++
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 339 VSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLK----ETAAREASAKLRLQQFIEELL 394
+ + L + K L E+ R+++E+ ++++ LK E+ + K Q I++ L
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 395 ERADRAE 401
E +A+
Sbjct: 1174 ELQGKAD 1180
Score = 30.8 bits (68), Expect = 6.2
Identities = 33/148 (22%), Positives = 68/148 (45%), Gaps = 15/148 (10%)
Query: 273 KLEVDRRLERLSEEVEQKIAGQVGR---LQAELERKAAELETARQES--------ARLGR 321
+L++ ++ E L E ++QK+ Q L+ + E + E + +E L +
Sbjct: 785 RLDLQKKSEAL-ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 322 EKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAR--- 378
K E E +ELS D ++ SLK E+E + + ++ +++ KE +
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 379 EASAKLRLQQFIEELLERADRAERQLQV 406
+ L+ Q+ +++ LE+ A QL++
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKL 931
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/173 (26%), Positives = 85/173 (49%), Gaps = 17/173 (9%)
Query: 252 PSPADVAYEEGLARLKIRALEKL-----EVDRR----LERLSEEVEQKIAGQVGRLQAEL 302
P P+D A E K++ALE+ EV+R+ LE+L +E++ K + A L
Sbjct: 391 PIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDAR-----ASL 445
Query: 303 ERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQ 362
ER E+ ++E + G+E ++L R EL E LA L+++ +++E +
Sbjct: 446 ERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLE 505
Query: 363 QEVVQID---QFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCG 412
QEV + QFL+ A+ + L++ ++L++ D +Q+ ++ G
Sbjct: 506 QEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAG 558
Score = 39.7 bits (91), Expect = 0.013
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 20/158 (12%)
Query: 263 LARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETA-RQESARLGR 321
LA + +A + R E + + Q++ +LQA LER+ ++E RQ+SA
Sbjct: 372 LAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQA-LERERTKVEEVNRQQSA---- 426
Query: 322 EKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREAS 381
+LE+ EL + D L L +++ ++ELS K QE Q+ + L+E A +S
Sbjct: 427 ---QLEQLVKELQLKEDARAS-LERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSS 482
Query: 382 -----AKLR----LQQFIEELLERADRA-ERQLQVISS 409
A+LR QQ +ELLE+ R+ RQLQ + +
Sbjct: 483 WEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLET 520
Score = 33.9 bits (76), Expect = 0.73
Identities = 31/145 (21%), Positives = 58/145 (40%), Gaps = 21/145 (14%)
Query: 275 EVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELS 334
+ ++R + L E Q++ +L AE+ + L+ A G E + L + E
Sbjct: 984 QAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNA-------GEECKSLRGQLEEQG 1036
Query: 335 RQVDVSVELLASLKQDLVHKEQELS--------------RKQQEVVQIDQFLKETAAREA 380
RQ+ + E + LK ++LS RK +E + + L+ T
Sbjct: 1037 RQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELE 1096
Query: 381 SAKLRLQQFIEELLERADRAERQLQ 405
A ++Q++ +L + ER Q
Sbjct: 1097 KATTKIQEYYNKLCQEVTNRERNDQ 1121
Score = 33.5 bits (75), Expect = 0.95
Identities = 34/158 (21%), Positives = 71/158 (44%), Gaps = 28/158 (17%)
Query: 264 ARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGR---LQAELERKAAELETARQESARLG 320
A+L +++ + L + + E+E+++ VGR L+ +L+ A+ + +Q + +
Sbjct: 598 AQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQ 657
Query: 321 REKEELE-ERAS--ELSRQVDVSV----ELLASLKQDLVHKEQELSRKQQEVVQIDQFLK 373
LE E+AS L Q++ S+ + ++K + KE L K+ E Q
Sbjct: 658 GSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQ------ 711
Query: 374 ETAAREASAKLRLQQFIEELLERADRAERQLQVISSSC 411
L++ +E+ + A+ R+L+ + S C
Sbjct: 712 ------------LREEVEQCQQLAEARHRELRALESQC 737
Score = 33.5 bits (75), Expect = 0.95
Identities = 36/125 (28%), Positives = 54/125 (43%), Gaps = 8/125 (6%)
Query: 285 EEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELL 344
E VE+ +A V LQ E + E E ++ A L +EKE L+E+ + + L
Sbjct: 920 ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL----KAAKAAAGSL 975
Query: 345 ASLKQDLVHKEQELSRKQQEVVQIDQFLK-ETAAREASAKLRLQQFIEE---LLERADRA 400
L+ L EQ Q+ Q LK + +A + RL+ EE L + +
Sbjct: 976 PGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQ 1035
Query: 401 ERQLQ 405
RQLQ
Sbjct: 1036 GRQLQ 1040
Score = 32.7 bits (73), Expect = 1.6
Identities = 39/159 (24%), Positives = 65/159 (40%), Gaps = 17/159 (10%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEE---VEQKIAGQVGRLQAELERKAAELETARQES 316
E+ A + E L+ R L EE Q+ ++ LQ EL + E A+ E
Sbjct: 832 EQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEH 891
Query: 317 ARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETA 376
A L + +EL QV +L + E+ L+ QE+ Q KE A
Sbjct: 892 AELQEQLHRANTDTAELGIQV-------CALTVEKERVEEALACAVQEL----QDAKEAA 940
Query: 377 AREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTP 415
+RE L++ + L + + + +L+ ++ GS P
Sbjct: 941 SREREG---LERQVAGLQQEKESLQEKLKAAKAAAGSLP 976
Score = 31.2 bits (69), Expect = 4.7
Identities = 39/146 (26%), Positives = 73/146 (50%), Gaps = 20/146 (13%)
Query: 269 RALEKLEVDRRLERLSEEVEQ-KIAGQVGRLQ-AELERKAAELETARQESARLGR----- 321
RA E + + L L EE+ Q K + + +L+ AEL+ +L A ++A LG
Sbjct: 859 RADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQE---QLHRANTDTAELGIQVCAL 915
Query: 322 --EKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAARE 379
EKE +EE + +++ + E + ++ L E++++ QQE + + LK AA+
Sbjct: 916 TVEKERVEEALACAVQELQDAKEAASREREGL---ERQVAGLQQEKESLQEKLK--AAKA 970
Query: 380 ASAKLRLQQFIEELLERADRAERQLQ 405
A+ L ++ L +A++ + LQ
Sbjct: 971 AAGSL---PGLQAQLAQAEQRAQSLQ 993
>gi|150010604 kinesin family member 4B [Homo sapiens]
Length = 1234
Score = 49.7 bits (117), Expect = 1e-05
Identities = 38/144 (26%), Positives = 73/144 (50%), Gaps = 13/144 (9%)
Query: 254 PADVAYEEGLARLKIRAL----EKLEVDRRLERLSEEVEQ-KIAGQVGRLQAELERKAAE 308
P Y++ + L++ + EK E+ R L+ + V Q K++ +L ELE + A+
Sbjct: 552 PIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIAD 611
Query: 309 LETARQESARLGREKEELEERASELSRQV----DVSVELLASLKQDLVHKEQELSRKQQE 364
L+ E ++L + KE E S+L++++ + V+L+ +K+D Q +K +E
Sbjct: 612 LKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKE 671
Query: 365 VVQIDQFLKETAAREASAKLRLQQ 388
V+Q LKE + L+L++
Sbjct: 672 VIQ----LKERDRKRQYELLKLER 691
Score = 31.6 bits (70), Expect = 3.6
Identities = 19/89 (21%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 286 EVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLA 345
E+E ++ ++ R++ + + K L + QES +++LE+ ASE +Q+ +++
Sbjct: 911 EIETELQAELVRMEQQHQEKVLYLVSQLQESQMA---EKQLEKSASEKEQQLVSTLQ--- 964
Query: 346 SLKQDLVHKEQELSRKQQEVVQIDQFLKE 374
+ + + K +E+ + Q+++Q ++ +K+
Sbjct: 965 -CQDEELEKMREVCEQNQQLLQENEIIKQ 992
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 49.7 bits (117), Expect = 1e-05
Identities = 70/276 (25%), Positives = 114/276 (41%), Gaps = 42/276 (15%)
Query: 609 PEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVW----TRVLLENARVCSKF 664
PE+L M IF YLD R AA+VC WR A H +VW ++ L A S F
Sbjct: 10 PELLAM------IFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANP-SLF 62
Query: 665 LAMLAQWCTQAHSLTL-QNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLIL 723
++ A+ + L+L ++L +G + + GL G+L L
Sbjct: 63 PSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRAL 122
Query: 724 RISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLH 783
+S C I TD SL + Y + L+ + ++ + + + + G + + SL L
Sbjct: 123 NLSLCKQI-TDSSLGRIAQYLKGLEVLELGGCSN-ITNTGLLLIAWGLQRLKSLN---LR 177
Query: 784 PCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLA-SLARNCMRLQVLELDHVSEI 842
C+ HL +G+G + G+ S A C+ L+ L L ++
Sbjct: 178 SCR------------------HLSDVGIG----HLAGMTRSAAEGCLGLEQLTLQDCQKL 215
Query: 843 TQEVAAEVCREGLKGLEMLVLT-ATPVTPKALLHFN 877
T + R GL GL +L L+ ++ LLH +
Sbjct: 216 TDLSLKHISR-GLTGLRLLNLSFCGGISDAGLLHLS 250
>gi|150378549 tangerin [Homo sapiens]
Length = 1523
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/207 (28%), Positives = 79/207 (38%), Gaps = 34/207 (16%)
Query: 424 GGGGAGPNARGPG---------------RMREHHV-GPAVPNTYAVSRHGSSPSTGASSR 467
GGGGAG G R+R H GP P A G++P + +
Sbjct: 1153 GGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGPQEPKEAADRADGAAPGVASRNA 1212
Query: 468 VPAASQSSGCYDSDSLELPR--PEEGAPEDSG-PGGLGTRAQ--AANGGSERSQPPRSSG 522
V + G ++ P P EG +G PGG G R + + NG PPR+ G
Sbjct: 1213 VAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHG 1272
Query: 523 L---RRQAIQNWQRRPRRHSTEGEEGDVSDVGSR-TTESEAEGPLDAPRPGPAMAGPLSS 578
R A +RR R ++ D D G+ +E + P +P PGP A
Sbjct: 1273 SFSHVRDADLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAAD--- 1329
Query: 579 CRLSARPEGGSGRGRRAERVSPSRSNE 605
S +P GGS +E PS E
Sbjct: 1330 ---SQQPPGGSS---PSEEPPPSPGEE 1350
Score = 45.8 bits (107), Expect = 2e-04
Identities = 48/192 (25%), Positives = 85/192 (44%), Gaps = 24/192 (12%)
Query: 225 ASSACSTPPPGPGPGPCPG------PASASPASPSPADVAYEEGLARLKIRALEKLEVDR 278
A++ P P P PGP P +SP+ P E GL R + + +
Sbjct: 1309 AAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQ 1368
Query: 279 RLERLSEEVEQKIAGQVGRLQAELERKAAEL--ETARQESARLGREKEELEERASELSRQ 336
LE+ +++ + A +L++ +E A +L E QE L +K L R +L
Sbjct: 1369 ALEQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQ-- 1426
Query: 337 VDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFI------ 390
L +QDL + + LSR+ + ++ I+ + K T+A++ +L L++ +
Sbjct: 1427 -------LLMEEQDLERRFELLSRELRAMLAIEDWQK-TSAQQHREQLLLEELVSLVNQR 1478
Query: 391 EELLERADRAER 402
+EL+ D ER
Sbjct: 1479 DELVRDLDHKER 1490
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 49.3 bits (116), Expect = 2e-05
Identities = 42/154 (27%), Positives = 74/154 (48%), Gaps = 15/154 (9%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
++ R + +EV + + EE QK Q+ R Q E E+K E+ A +E R+ REKEE
Sbjct: 292 MRRRKPDTIEVQQMKAQAREEKHQK---QLERAQLENEKKKREI--AEKEKERIEREKEE 346
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
L ER ++ Q + + L + + +QE R ++E ++++ + AA EA + +
Sbjct: 347 LMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEK--ERRAAEEAKSAIA 404
Query: 386 LQQFIEELLERADRAERQLQVISSSCGSTPSASL 419
Q AD+ + Q Q+ + T +L
Sbjct: 405 KQ--------AADQMKNQEQLAAELAEFTAKIAL 430
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/83 (31%), Positives = 39/83 (46%)
Query: 269 RALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEE 328
RA E+ E + R +EE + IA Q E+ AAEL + A L K++ EE
Sbjct: 381 RAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEE 440
Query: 329 RASELSRQVDVSVELLASLKQDL 351
A+E + + E L K++L
Sbjct: 441 EATEWQHKAFAAQEDLEKTKEEL 463
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 49.3 bits (116), Expect = 2e-05
Identities = 44/143 (30%), Positives = 70/143 (48%), Gaps = 9/143 (6%)
Query: 267 KIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEEL 326
++R LE+ E+ R ER EE +Q Q R + +L RK E +QE R +E+ E
Sbjct: 277 QLRKLERQELRR--ERQEEEQQQ----QRLRREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 327 EE--RASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKL 384
+E R +L R+ + E +Q+ +EQ+L R+Q+E + Q +E R
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 385 RLQQF-IEELLERADRAERQLQV 406
R QQ E+ L R + R+ Q+
Sbjct: 391 REQQLRREQQLRREQQLRREQQL 413
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/128 (29%), Positives = 65/128 (50%), Gaps = 13/128 (10%)
Query: 271 LEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAE-LETARQESARLGREKEELEER 329
L K E +RR +RL E E+ RL+ L+R+ E LE + RL RE+ E EER
Sbjct: 578 LLKREEERRQQRLKREQEE-------RLEQRLKREEVERLEQEERREQRLKREEPE-EER 629
Query: 330 ASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQF 389
+L + + L+++ + ++ ++++E +++Q LK RE + R Q+
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK----REHEEERREQEL 685
Query: 390 IEELLERA 397
EE E+A
Sbjct: 686 AEEEQEQA 693
Score = 43.9 bits (102), Expect = 7e-04
Identities = 45/146 (30%), Positives = 71/146 (48%), Gaps = 11/146 (7%)
Query: 265 RLKIRALEKLEVDRRLERLSEEVEQKIAGQ-VGRLQAELERKAAELETARQESARLGREK 323
R K R E+ R E L +E EQ + + R + ELER+ + E +QE +L RE+
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 324 EEL---EERASELSRQVDVSVELLASLKQDL-VHKEQELSRKQQEVVQIDQFLKETAARE 379
E +ER + + ++ E L+++ + QEL R+ +E ++ Q +E RE
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ-EEEQLLRE 1156
Query: 380 ASAKLRLQQFIEELLERADRAERQLQ 405
K R Q+ LER R E +LQ
Sbjct: 1157 EPEKRRRQE-----LERQYREEEELQ 1177
Score = 43.5 bits (101), Expect = 0.001
Identities = 37/140 (26%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 266 LKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEE 325
LK ++LE +RR +RL E E++ + L+ E ER+ L+ ++E ++EE
Sbjct: 550 LKREEEKRLEQERREQRLKREQEER---RDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 326 LEERASELSRQVDVS-VELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKL 384
+E E R+ + E +Q L+ E++ R+QQ++ + Q +E + +
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 385 RLQQFIEELLERADRAERQL 404
RL+Q ++ E +R E++L
Sbjct: 667 RLEQRLKREHEE-ERREQEL 685
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/156 (25%), Positives = 76/156 (48%), Gaps = 11/156 (7%)
Query: 258 AYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESA 317
A EE L K E+ + +L R E +E + G+ + Q ER+ + ++
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRR-RELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 318 R-----LGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFL 372
R L +E+E+L+E + R++ E L L++ + +E++ +QQ+ ++ +Q L
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 373 K---ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
+ E RE + R QQ E ++ +R E+QL+
Sbjct: 307 RRKQEEERREQQEERREQQ--ERREQQEERREQQLR 340
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/127 (29%), Positives = 63/127 (49%), Gaps = 10/127 (7%)
Query: 267 KIRALEKLEVDRRLERLSEEVEQKIAGQ-VGRLQAELERKAAELETARQESARLGREKEE 325
K R E+ R E L +E EQ + + R + ELER+ E E +QE +L RE+ E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 326 LEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLR 385
+ R EL RQ +++L +E++L R++QE + ++ + E + R
Sbjct: 1160 -KRRRQELERQYRE--------EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 386 LQQFIEE 392
Q++ +E
Sbjct: 1211 KQRYRDE 1217
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 13/144 (9%)
Query: 269 RALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEE 328
R ++L +++L R EE +++ + + E ER+ L+ QE R K E E
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK-REQEERRDQLLKREEER 585
Query: 329 RASELSRQVDVSVELLASLKQDLV-------HKEQELSRKQQEVVQIDQFLK---ETAAR 378
R L R+ + +E LK++ V +EQ L R++ E + Q LK + R
Sbjct: 586 RQQRLKREQEERLE--QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 379 EASAKLRLQQFIEELLERADRAER 402
+ + Q+ E+ L+R + ER
Sbjct: 644 QQQLRREQQERREQRLKREEEEER 667
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/143 (26%), Positives = 66/143 (46%), Gaps = 17/143 (11%)
Query: 267 KIRALEKLEVDRRLERLSEEVEQKIAGQ-VGRLQAELER---KAAELETARQESARLGRE 322
K R E+ + R E L +E EQ + + R + E ER K EL+ ++ R RE
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 323 KEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASA 382
K L+ER + + ++ E ++ L+ +E+E R+Q+ L+ +E
Sbjct: 1040 KRRLQERERQYREEEELQQE-----EEQLLGEERETRRRQE--------LERQYRKEEEL 1086
Query: 383 KLRLQQFIEELLERADRAERQLQ 405
+ +Q + E E+ R ER+ Q
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQ 1109
Score = 37.7 bits (86), Expect = 0.050
Identities = 33/147 (22%), Positives = 66/147 (44%), Gaps = 3/147 (2%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE + ++R ++L + ER ++ E++ Q R + + ER+ +L ++E
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERR--EQQERREQQEERREQQLRREQEERREQ 349
Query: 320 GREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAARE 379
+E+ EER + R+ L+++ + ++ R++Q++ + Q +E R
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 380 ASAKLRLQQF-IEELLERADRAERQLQ 405
R QQ E+ L R ER Q
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQ 436
Score = 37.4 bits (85), Expect = 0.066
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 11/139 (7%)
Query: 265 RLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELER----KAAELETARQESARLG 320
RLK E+ + +R E +++ Q+ R Q E R K E E Q+ R
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 321 REKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREA 380
+ + E EER + ++ + L Q + EQ+L R+Q+E + +Q LK +
Sbjct: 506 QLRREQEERREQRLKRQEEEERL-----QQRLRSEQQLRREQEE--RREQLLKREEEKRL 558
Query: 381 SAKLRLQQFIEELLERADR 399
+ R Q+ E ER D+
Sbjct: 559 EQERREQRLKREQEERRDQ 577
Score = 37.4 bits (85), Expect = 0.066
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 13/145 (8%)
Query: 265 RLKIRALEKLEVDRRLERLSE-EVEQKIAGQVGRLQAELERKAAELETARQESARLGREK 323
RLK E+LE + E + E E++ ++ R + E ER+ L++ QE R + +
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 324 EELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAK 383
E +ER + ++ + L LK +E E R++QE+ + +Q ARE K
Sbjct: 649 REQQERREQRLKREEEEERLEQRLK-----REHEEERREQELAEEEQ----EQARE-RIK 698
Query: 384 LRLQQFIEELLERADRAERQLQVIS 408
R+ ++ +L AD RQ +V S
Sbjct: 699 SRIPKWQWQLESEAD--ARQSKVYS 721
Score = 37.4 bits (85), Expect = 0.066
Identities = 45/151 (29%), Positives = 70/151 (46%), Gaps = 20/151 (13%)
Query: 272 EKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERAS 331
E+L +++L + EE Q+ + R Q E ER+ E E +QE +L RE+ E + R
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQ-EQERQYREEEQLQQEEEQLLREERE-KRRRQ 954
Query: 332 ELSRQVDVSVELLASLKQDL-----VHKEQELSRKQQEVVQIDQFLKETAAREASAKLRL 386
E RQ +L +Q L + QE +K +E ++ Q +E RE K R
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ-EEEQLLREEREKRRR 1013
Query: 387 QQF------------IEELLERADRAERQLQ 405
Q++ EE L R +R +R+LQ
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQ 1044
Score = 35.8 bits (81), Expect = 0.19
Identities = 31/137 (22%), Positives = 64/137 (46%), Gaps = 10/137 (7%)
Query: 272 EKLEVDRRLERLSEEVEQK---IAGQVGRLQAELERKAAELETARQESARLGREKEELEE 328
+K E +RR +RL E E++ + + + E ER+ +L+ ++E R K E EE
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 329 RASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQ 388
R + R+ L+++ + ++ ++Q+E ++ Q L+ + R +Q
Sbjct: 496 RREQQERREQ-------QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 389 FIEELLERADRAERQLQ 405
++ E+ ER+ Q
Sbjct: 549 LLKREEEKRLEQERREQ 565
Score = 35.8 bits (81), Expect = 0.19
Identities = 30/128 (23%), Positives = 67/128 (52%), Gaps = 8/128 (6%)
Query: 278 RRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQV 337
R E+L +E E++ Q+ R + + + + E + RQE R ++E+ + R EL R+
Sbjct: 1670 REEEQLLQEGEEQ---QLRRQERDRKFREEEQQLRRQERERKFLQEEQ-QLRRQELERKF 1725
Query: 338 DVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERA 397
+L +Q+ + +++ + +++++ +Q E ++ + R ++F EE R
Sbjct: 1726 REEEQLRQETEQEQLRRQE----RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781
Query: 398 DRAERQLQ 405
+R E+QL+
Sbjct: 1782 EREEQQLR 1789
Score = 34.3 bits (77), Expect = 0.56
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 12/134 (8%)
Query: 272 EKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETAR--QESARLGREKEELEER 329
E+ +++R ++ ++ ++K + L+ E E K ET R +E +L +E+EE R
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 330 ASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQF 389
E R+ + + +EQ L R+++E +FLKE +LR Q+
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE----RKFLKE------EQQLRCQER 1404
Query: 390 IEELLERADRAERQ 403
++L + DR R+
Sbjct: 1405 EQQLRQDRDRKFRE 1418
Score = 33.9 bits (76), Expect = 0.73
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 17/136 (12%)
Query: 278 RRLERLSEEVEQKIAGQ--VGRLQAELERKAAELETARQESARL------GREKEELEER 329
R+ + L +E EQ + + RLQ E ER+ E E +QE +L R ++ELE +
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQ-ERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Query: 330 ASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQF 389
+ +LL + +E+E +++E +Q ++ E RE K R Q+
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE---EQLLREEREKRRRQE- 1135
Query: 390 IEELLERADRAERQLQ 405
LER R E ++Q
Sbjct: 1136 ----LERQYREEEEVQ 1147
Score = 33.1 bits (74), Expect = 1.2
Identities = 32/131 (24%), Positives = 62/131 (47%), Gaps = 1/131 (0%)
Query: 275 EVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELS 334
E R ER +++ ++ + R + +L ++ E + QES R RE+E+L + E
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 335 RQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELL 394
+ ++ L +EQE R +QE + + ++ A +E S + + + EE
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQE-QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Query: 395 ERADRAERQLQ 405
+R ER+L+
Sbjct: 1871 KRRQERERKLR 1881
Score = 32.7 bits (73), Expect = 1.6
Identities = 38/158 (24%), Positives = 72/158 (45%), Gaps = 22/158 (13%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARL 319
EE R + R + L+ +++L R +E+E+K R + +L ++ + + RQE R
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRR--QELERKF-----REEEQLRQETEQEQLRRQERYRK 1748
Query: 320 GREKEELEERASE--LSRQ-------------VDVSVELLASLKQDLVHKEQELSRKQQE 364
E+E+L E L RQ + + L S + D +E+E R+++E
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808
Query: 365 VVQIDQFLKETAAREASAKLRLQQFIEELLERADRAER 402
Q+ ++ R +L+L++ + L + DR R
Sbjct: 1809 EQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Score = 32.3 bits (72), Expect = 2.1
Identities = 34/135 (25%), Positives = 65/135 (48%), Gaps = 4/135 (2%)
Query: 272 EKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELE-ERA 330
E+L + +R +E+E++ + Q E + E E RQE R RE+EEL+ ++
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 331 SELSRQVDVSVELLASLKQDLVH--KEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQ 388
+ R D +L + + + ++ ++ K +E Q Q L+++ R+ ++ LQ
Sbjct: 1211 KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ-LEDSQLRDRQSQQDLQH 1269
Query: 389 FIEELLERADRAERQ 403
+ E ER ER+
Sbjct: 1270 LLGEQQERDREQERR 1284
Score = 32.3 bits (72), Expect = 2.1
Identities = 43/178 (24%), Positives = 77/178 (43%), Gaps = 25/178 (14%)
Query: 249 PASPSPADVAYEEGLARLKIRALEKLEVDRRLER-------LSEEVEQKIAGQVGRLQAE 301
P D + E R + + + LE ++RL R L EE + + + +L+ +
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 302 LERKAAELET--ARQESARLGREKEE-----------LEER---ASELSRQVDVSVELLA 345
+RK E E +RQE R RE+E+ LEE E R+ +LL
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 346 SLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQ 403
++ +H+++ + +E Q+ + ++ RE +LR Q+ + LE + RQ
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE--QELRSQEPERKFLEEEQQLHRQ 1527
Score = 32.0 bits (71), Expect = 2.8
Identities = 42/160 (26%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 269 RALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELE---TARQESARLGREKEE 325
R L E +R +R E E+K + R + E E + E E R+ + +L E++
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 326 LEE-----RASELSRQVDVSVELLASLK------------QDLVHKEQELSRKQQEVVQI 368
L+E R+ E R +L K Q+ + KEQ+L ++++E +Q
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 369 DQFLK---ETAAREASAKLRLQQFIEELLERADRAERQLQ 405
++ K + R+ + +LQQ E+LL R +R +R+ Q
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLL-REEREKRRRQ 954
Score = 31.6 bits (70), Expect = 3.6
Identities = 34/146 (23%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 267 KIRALEKLEVDRRLERLS-EEVEQKIAGQVGRLQA-ELERKAAELETARQESARLGREKE 324
K R E+L +R ++L +E ++K + +L+ E +RK E E QE R E+E
Sbjct: 1462 KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 325 ELEERASELSRQVDVSVELLASLK-------QDLVHKEQELSRKQQEVVQIDQFLKETAA 377
+ R + + +L + +D +E+E R+++E Q+ + ++
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581
Query: 378 REASAKLRLQQFIEELLERADRAERQ 403
R K+R Q+ + +E + RQ
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQ 1607
Score = 31.2 bits (69), Expect = 4.7
Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 29/154 (18%)
Query: 272 EKLEVDRRLERLSEEVE------------QKIAGQVGRLQAELERKA---------AELE 310
E+L+ R ++L EE + ++ Q R Q E ERK A E
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 311 TARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQ 370
R+E L E+EEL+ E R+ + E ++ L +E++L R+++E +
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQE--QERQYREEEQLQQEEEQLLREERE-----K 950
Query: 371 FLKETAAREASAKLRLQQFIEELL-ERADRAERQ 403
++ R+ +LQQ E+LL E ++ RQ
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984
Score = 30.8 bits (68), Expect = 6.2
Identities = 46/190 (24%), Positives = 83/190 (43%), Gaps = 45/190 (23%)
Query: 260 EEGLARLKIRALEKLEVDRRLERLSEEVEQ----KIAGQVGRLQAELE------------ 303
EE RL+ R + E +RR + L+EE ++ +I ++ + Q +LE
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 304 ----------RKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDL-- 351
R+ E + R+ES +E+E + E ++ D + + A K +
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 352 --------VHKEQELSRKQQEVVQIDQ-FLKETAAREASAKLRLQ-----QFI--EELLE 395
+ +++E + +E Q +Q FL E +E + R + QF+ EE L+
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 396 RADRAERQLQ 405
R +RA+ QLQ
Sbjct: 842 RRERAQ-QLQ 850
Score = 30.8 bits (68), Expect = 6.2
Identities = 35/138 (25%), Positives = 65/138 (47%), Gaps = 16/138 (11%)
Query: 273 KLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELE-ERAS 331
+LE + +R S++ Q + G+ E ER+ Q+ R E+E+LE E
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW------QQRDRHFPEEEQLEREEQK 1305
Query: 332 ELSRQVDVSVELLASLKQDLVHKEQELSRKQQEV----VQIDQFLKETAAREASAKLRLQ 387
E R+ S E ++ L+ +E+E R++QE + +Q L+E + + R +
Sbjct: 1306 EAKRRDRKSQE-----EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 388 QFIEELLERADRAERQLQ 405
+F EE L ++ + L+
Sbjct: 1361 KFREEELRHQEQGRKFLE 1378
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/141 (26%), Positives = 74/141 (52%), Gaps = 19/141 (13%)
Query: 272 EKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESAR-------LGREKE 324
EK V++ L+ + ++Q+ + +V LQ E++R+ L+ + + + L +K
Sbjct: 34 EKNNVEQDLKEKEDTIKQRTS-EVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 92
Query: 325 ELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKL 384
+LEE+ E+ ++ +L++SLK +L +E ++S ++E+ + ARE +
Sbjct: 93 QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAK---------AREELS-- 141
Query: 385 RLQQFIEELLERADRAERQLQ 405
RLQQ EL E + + QL+
Sbjct: 142 RLQQETAELEESVESGKAQLE 162
Score = 41.2 bits (95), Expect = 0.005
Identities = 45/222 (20%), Positives = 94/222 (42%), Gaps = 14/222 (6%)
Query: 256 DVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQE 315
D+ +E + + ++ L+ + + E + + Q QV L EL+ + A+LE +E
Sbjct: 41 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 100
Query: 316 SARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKET 375
+ E+ +L S L ++ +++ +++L +ELSR QQE ++++ ++
Sbjct: 101 VRKKCAEEAQL---ISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESG 157
Query: 376 AAREASAKLRLQQFIEE-------LLERADRAERQLQVISSSCGSTPSASLGRGGGGGGA 428
A+ + LQ +E L+E D Q+ + C S S +
Sbjct: 158 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL--NWCSSPHSILVNGATDYCSL 215
Query: 429 GPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPA 470
++ + EH G + N + H SP+ + +P+
Sbjct: 216 STSSSETANLNEHVEGQS--NLESEPIHQESPARSSPELLPS 255
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/141 (26%), Positives = 74/141 (52%), Gaps = 19/141 (13%)
Query: 272 EKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESAR-------LGREKE 324
EK V++ L+ + ++Q+ + +V LQ E++R+ L+ + + + L +K
Sbjct: 348 EKNNVEQDLKEKEDTIKQRTS-EVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 406
Query: 325 ELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKL 384
+LEE+ E+ ++ +L++SLK +L +E ++S ++E+ + ARE +
Sbjct: 407 QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAK---------AREELS-- 455
Query: 385 RLQQFIEELLERADRAERQLQ 405
RLQQ EL E + + QL+
Sbjct: 456 RLQQETAELEESVESGKAQLE 476
Score = 41.2 bits (95), Expect = 0.005
Identities = 45/222 (20%), Positives = 94/222 (42%), Gaps = 14/222 (6%)
Query: 256 DVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQE 315
D+ +E + + ++ L+ + + E + + Q QV L EL+ + A+LE +E
Sbjct: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
Query: 316 SARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKET 375
+ E+ +L S L ++ +++ +++L +ELSR QQE ++++ ++
Sbjct: 415 VRKKCAEEAQL---ISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
Query: 376 AAREASAKLRLQQFIEE-------LLERADRAERQLQVISSSCGSTPSASLGRGGGGGGA 428
A+ + LQ +E L+E D Q+ + C S S +
Sbjct: 472 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL--NWCSSPHSILVNGATDYCSL 529
Query: 429 GPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPA 470
++ + EH G + N + H SP+ + +P+
Sbjct: 530 STSSSETANLNEHVEGQS--NLESEPIHQESPARSSPELLPS 569
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 7/102 (6%)
Query: 308 ELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQ 367
EL+T E L REK +E+ E + + L+ ++ + L + Q + Q
Sbjct: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
Query: 368 IDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISS 409
+ + L E ++A Q E+L E + + Q+ISS
Sbjct: 394 VQELLDELDEQKA-------QLEEQLKEVRKKCAEEAQLISS 428
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/182 (29%), Positives = 78/182 (42%), Gaps = 5/182 (2%)
Query: 217 ELFARKSVASSACSTPPPGPGPGPCPGPAS-ASPASPSPADVAYEEGLARLKIRALEK-L 274
EL + +A A P PG P P S A A P P E L+ IR EK L
Sbjct: 53 ELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLS--VIRQKEKDL 110
Query: 275 EVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKE-ELEERASEL 333
+ RL + E Q ++ Q ++ EL K LE + E R +E E E R SEL
Sbjct: 111 VLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSEL 170
Query: 334 SRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEEL 393
V + L + L ++E SR QE+ + +Q L + +R + + +L + L
Sbjct: 171 ESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHAL 230
Query: 394 LE 395
E
Sbjct: 231 RE 232
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 48.5 bits (114), Expect = 3e-05
Identities = 93/449 (20%), Positives = 165/449 (36%), Gaps = 48/449 (10%)
Query: 194 AEPGLVPAAAARYALRE---------IEIPLGELFARKSVASSACSTPPPGPGPGPCPGP 244
A+PG+V A A + + +E+ E + A+SA + PG G P P
Sbjct: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVR-AASAPAKGTPGKGATPAPPG 244
Query: 245 ASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQA---E 301
+ + AS + A E+ + + + + E L + K + QVG A E
Sbjct: 245 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS-QVGAASAPAKE 303
Query: 302 LERKAAELETARQES-----ARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQ 356
RK A + A+ G+ +E+ + + E + + + S K V
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 357 ELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAER---------QLQVI 407
+++ ++T A ++ Q+ ++R Q++ +
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 408 SSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVP---------NTYAVSRHGS 458
S P++++G G G GAGP PG+ VGPA P ++ + S S
Sbjct: 424 GKSPQVKPASTMGMGPLGKGAGPVP--PGK-----VGPATPSAQVGKWEEDSESSSEESS 476
Query: 459 SPSTG--ASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQ 516
S G ++ PA +S G + P +G P+ +GP + +A+ SE S+
Sbjct: 477 DSSDGEVPTAVAPAQEKSLGNI-LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 535
Query: 517 PPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPL 576
S +A + + + + + TT S P+ P AG
Sbjct: 536 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 595
Query: 577 SSCRLSARPEGGSGRGRRAERVSPSRSNE 605
+S + P G R AE S S ++
Sbjct: 596 TS-PAGSSPAVAGGTQRPAEDSSSSEESD 623
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 48.5 bits (114), Expect = 3e-05
Identities = 93/449 (20%), Positives = 165/449 (36%), Gaps = 48/449 (10%)
Query: 194 AEPGLVPAAAARYALRE---------IEIPLGELFARKSVASSACSTPPPGPGPGPCPGP 244
A+PG+V A A + + +E+ E + A+SA + PG G P P
Sbjct: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVR-AASAPAKGTPGKGATPAPPG 244
Query: 245 ASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQA---E 301
+ + AS + A E+ + + + + E L + K + QVG A E
Sbjct: 245 KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS-QVGAASAPAKE 303
Query: 302 LERKAAELETARQES-----ARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQ 356
RK A + A+ G+ +E+ + + E + + + S K V
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 357 ELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAER---------QLQVI 407
+++ ++T A ++ Q+ ++R Q++ +
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 408 SSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVP---------NTYAVSRHGS 458
S P++++G G G GAGP PG+ VGPA P ++ + S S
Sbjct: 424 GKSPQVKPASTMGMGPLGKGAGPVP--PGK-----VGPATPSAQVGKWEEDSESSSEESS 476
Query: 459 SPSTG--ASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQ 516
S G ++ PA +S G + P +G P+ +GP + +A+ SE S+
Sbjct: 477 DSSDGEVPTAVAPAQEKSLGNI-LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 535
Query: 517 PPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPL 576
S +A + + + + + TT S P+ P AG
Sbjct: 536 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 595
Query: 577 SSCRLSARPEGGSGRGRRAERVSPSRSNE 605
+S + P G R AE S S ++
Sbjct: 596 TS-PAGSSPAVAGGTQRPAEDSSSSEESD 623
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,950,667
Number of Sequences: 37866
Number of extensions: 2329561
Number of successful extensions: 35373
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 431
Number of HSP's successfully gapped in prelim test: 1357
Number of HSP's that attempted gapping in prelim test: 23947
Number of HSP's gapped (non-prelim): 9991
length of query: 936
length of database: 18,247,518
effective HSP length: 112
effective length of query: 824
effective length of database: 14,006,526
effective search space: 11541377424
effective search space used: 11541377424
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.