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Search of human proteins with 29294615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
(841 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 1735 0.0
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 884 0.0
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 855 0.0
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 514 e-145
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 434 e-121
gi|37577159 calcium-sensing receptor [Homo sapiens] 417 e-116
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 366 e-101
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 345 1e-94
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 259 9e-69
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 259 9e-69
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 255 1e-67
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 255 1e-67
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 245 1e-64
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 235 1e-61
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 229 6e-60
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 224 2e-58
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 218 1e-56
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 218 1e-56
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 202 8e-52
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 202 8e-52
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 69 2e-11
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 55 2e-07
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 2e-07
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 2e-07
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 53 1e-06
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 45 3e-04
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 45 3e-04
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 45 3e-04
gi|134152694 guanylate cyclase 2F [Homo sapiens] 40 0.007
gi|33356136 hypothetical protein LOC222223 isoform 2 [Homo sapiens] 39 0.015
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 1735 bits (4493), Expect = 0.0
Identities = 841/841 (100%), Positives = 841/841 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
Query: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA
Sbjct: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
Query: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS
Sbjct: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
Query: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS
Sbjct: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
Query: 421 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 480
LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE
Sbjct: 421 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 480
Query: 481 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG 540
TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG
Sbjct: 481 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG 540
Query: 541 KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA 600
KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA
Sbjct: 541 KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA 600
Query: 601 GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF 660
GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF
Sbjct: 601 GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF 660
Query: 661 KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC 720
KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC
Sbjct: 661 KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC 720
Query: 721 TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA 780
TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA
Sbjct: 721 TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA 780
Query: 781 SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS 840
SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS
Sbjct: 781 SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS 840
Query: 841 T 841
T
Sbjct: 841 T 841
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 884 bits (2284), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 421 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 480
LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 226
Query: 481 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG 540
TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG
Sbjct: 227 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCG 286
Query: 541 KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA 600
KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA
Sbjct: 287 KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSA 346
Query: 601 GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF 660
GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF
Sbjct: 347 GGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF 406
Query: 661 KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC 720
KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC
Sbjct: 407 KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLEC 466
Query: 721 TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA 780
TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA
Sbjct: 467 TETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTA 526
Query: 781 SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS 840
SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS
Sbjct: 527 SVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGS 586
Query: 841 T 841
T
Sbjct: 587 T 587
Score = 345 bits (884), Expect = 1e-94
Identities = 166/167 (99%), Positives = 167/167 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMI 167
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPM+
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 855 bits (2209), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKR 180
Query: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA
Sbjct: 181 QYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA 240
Query: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS
Sbjct: 241 FKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVAS 300
Query: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS
Sbjct: 301 EAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS 360
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQ 420
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 514 bits (1325), Expect = e-145
Identities = 303/819 (36%), Positives = 436/819 (53%), Gaps = 19/819 (2%)
Query: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRP--EVTLCDRSCSFNEHGYHLFQAMRLGVEEINN 88
DF LPGDYLL GLF LH+ + H +V +C + GY+L QAMR VEEINN
Sbjct: 26 DFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMC-KEYEVKVIGYNLMQAMRFAVEEINN 84
Query: 89 STALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDS 148
++LLP + LGY++ DVC S NV L L+ + + +Q D +Y V+AVIGPD+
Sbjct: 85 DSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHE-DNLLPIQEDYSNYISRVVAVIGPDN 143
Query: 149 TNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGW 208
+ T A LS FL+P I+Y+A S+ L K ++P+ LRT P+ + +E MV L+ F W
Sbjct: 144 SESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRW 203
Query: 209 TWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPF------SAQVGDERMQCLMRH 262
WI ++ SSD YG+ Q L + + ICIAF++ +P +R+ ++
Sbjct: 204 NWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDK 263
Query: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVL 322
L Q+ A VVVVFS FF V+ N TG VW+ASE+WA+ + + ++ +G L
Sbjct: 264 LQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFL 323
Query: 323 GVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWC-SSNQLCRECQAFMAHTMPKLKAF 381
G+ IQ +PG F E +A P P + S + NQ C C L+
Sbjct: 324 GITIQSVPIPGFSEFREWGPQA---GPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLS 380
Query: 382 SMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVHFLLHKDTVAFND 441
Y+ Y AVYAVAH LH LLGC C++ VYPWQLLE+I KV+F L + F+
Sbjct: 381 GERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDP 440
Query: 442 NRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI-NETKIQWHGKDNQVPKSVCSSD 500
D I+ W W+ + F + S + P+Q + N I WH +N +P S+CS
Sbjct: 441 QGDVALHLEIVQWQWDRSQNPFQSVAS--YYPLQRQLKNIQDISWHTINNTIPMSMCSKR 498
Query: 501 CLEGHQRVVTGFHHCCFECVPCGAGTFLNKS-DLYRCQPCGKEEWAPEGSQTCFPRTVVF 559
C G ++ G H CCFEC+ C GTFLN + D Y CQ C EW+ + +CF R +VF
Sbjct: 499 CQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVF 558
Query: 560 LALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSL 619
L E + + L L L +F H TP+VRSAGG +CFLML L +
Sbjct: 559 LEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVV 618
Query: 620 YGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGA 679
+ G P CL RQALF L FTI +SC+ VRSFQ++ FK +++ P Y WV+ G
Sbjct: 619 PVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGP 678
Query: 680 GLFVMISSAAQLLICLTWLVVWTPLP-AREYQRFPHLVMLECTETNSLGFILAFLYNGLL 738
+ + + +++I + ++ P R P + ++ C + + LL
Sbjct: 679 YVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLL 738
Query: 739 SISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLS 798
S+ F+ +Y+GK+LP NYNEAK +T S+ F F S ++ T S Y G + +++ +
Sbjct: 739 SVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVL 798
Query: 799 SLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRR 837
+L + GYF PKCY+IL P+ N+ +F + IQ YT R
Sbjct: 799 NLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMR 837
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 434 bits (1117), Expect = e-121
Identities = 274/821 (33%), Positives = 417/821 (50%), Gaps = 39/821 (4%)
Query: 29 SPDFTLPGDYLLAGLFPL---HSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEE 85
S + GDY+L GLFPL L+ R RP +C R F+ +G AM++ VEE
Sbjct: 26 SQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTR---FSSNGLLWALAMKMAVEE 82
Query: 86 INNSTALLPNITLGYQLYDVCSDSA-NVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVI 144
INN + LLP + LGY L+D CS+ + +L L+ G I + Y P VLAVI
Sbjct: 83 INNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVI 142
Query: 145 GPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQ 204
GP S+ A T S FL+P +SY AS E LS + +PSF RT+P+D+ Q+ LLQ
Sbjct: 143 GPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQ 202
Query: 205 KFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM---QCLMR 261
+FGW W++ +GS D+YG+ G+ A +GICIA + ++P + D R+ Q ++
Sbjct: 203 EFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLP-RADDSRLGKVQDVLH 261
Query: 262 HLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMV 321
+ Q+ VV++F+S A F + + L+ KVWVASEAW S + G+PG+ ++G V
Sbjct: 262 QVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTV 321
Query: 322 LGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS-------------NQLCRECQ 368
LG +Q+ A L F + A P ++CS+ Q C +C
Sbjct: 322 LGF-LQRGAQ--LHEFPQYVKTHLALATDP----AFCSALGEREQGLEEDVVGQRCPQCD 374
Query: 369 AFMAHTMPKLKA-FSMSSAYNAYRAVYAVAHGLHQLLGC-ASGACSRGRVYPWQLLEQIH 426
T+ + A + ++ Y AVY+VA LH L C ASG ++ V PWQLLE ++
Sbjct: 375 CI---TLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMY 431
Query: 427 KVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINETKIQWH 486
+ F + + F+ + + Y++ W W G +G S L KI+WH
Sbjct: 432 NLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGS---LRTERLKIRWH 488
Query: 487 GKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAP 546
DNQ P S CS C EG R V GFH CC++CV C AG++ D C CG++EW+P
Sbjct: 489 TSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSP 548
Query: 547 EGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCF 606
E S CF R FLA E +LL +L L L+L GLF H D+P+V+++GG L
Sbjct: 549 ERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLAC 608
Query: 607 LMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKV 666
L L S+ F G+P+ CL +Q L L T LS L +++ ++ + +
Sbjct: 609 FGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSW 668
Query: 667 PTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETNSL 726
++ A L V+++ ++ +C +LV + P ++ P ++ C + +
Sbjct: 669 ADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWV 728
Query: 727 GFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGK 786
F LA N L+ F ++L + P YN A+ +TF++L F++W++F +
Sbjct: 729 SFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVV 788
Query: 787 YLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHF 827
PA M A L + + LP+CY+++ +P LN+ E F
Sbjct: 789 LRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFF 829
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 417 bits (1073), Expect = e-116
Identities = 269/882 (30%), Positives = 435/882 (49%), Gaps = 78/882 (8%)
Query: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
Query: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
Query: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQ 181
I+ + + P+ +AV+G + + A LL F +P +SYA+SS LS K Q
Sbjct: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179
Query: 182 YPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAF 241
+ SFLRTIPND++Q M +++ F W W+ + + DDYG+ G++ +A + ICI F
Sbjct: 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF 239
Query: 242 KDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASE 301
+++ S +E +Q ++ + + A V+VVFSS + +V N+TGK+W+ASE
Sbjct: 240 SELI--SQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
Query: 302 AWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAF-------------------EEAY- 341
AWA S I +G +G A++ +PG + F EE +
Sbjct: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
Query: 342 --ARADKKAPRPCH-------------KGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSA 386
+ K P P S + LC + + P + + +
Sbjct: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
Query: 387 YNAYRAVYAVAHGLHQLLGC-------ASGACSR-GRVYPWQLLEQIHKVHFLLHK-DTV 437
YN Y AVY++AH L + C +G+C+ +V WQ+L+ + ++F + + V
Sbjct: 418 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQV 477
Query: 438 AFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPV-----QLNINETKIQWHGKDNQV 492
F++ D + +Y+II W + + ++ +L INE KI W G +V
Sbjct: 478 TFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREV 537
Query: 493 PKSVCSSDCLEGHQR-VVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQT 551
P S CS DCL G ++ ++ G CCFECV C G + +++D C C + W+ E +
Sbjct: 538 PFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTS 597
Query: 552 CFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGS 611
C + + FL+ E L L + L G+F +TP+V++ L +L+L S
Sbjct: 598 CIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFS 657
Query: 612 LAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYH 671
L S F GEP C LRQ F + F + +SC+ V++ +++++F+ K+PT +H
Sbjct: 658 LLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE--AKIPTSFH 715
Query: 672 -AWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETN--SLGF 728
W + L V + + Q++IC+ WL P R + ++ + C E + +LGF
Sbjct: 716 RKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF 775
Query: 729 ILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYL 788
++ Y LL+ F ++ + LPEN+NEAK +TFS+L F+ WI+F + GK++
Sbjct: 776 LIG--YTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFV 833
Query: 789 PAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQAS 830
A ++A L++ F K Y+IL +P N+ E + S
Sbjct: 834 SAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCS 875
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 366 bits (939), Expect = e-101
Identities = 243/850 (28%), Positives = 410/850 (48%), Gaps = 50/850 (5%)
Query: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
C + + T PG ++ GLF +H L P F + AM
Sbjct: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
Query: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
Query: 140 VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
V AVIG + + +L+ L+P + Y +++E LS K ++PSFLRT+P+D +Q++ M
Sbjct: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199
Query: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQC- 258
L+QK GW WI ++ + DDYG+L + QA +CIAFK+++P A + D ++
Sbjct: 200 AHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP--AFLSDNTIEVR 257
Query: 259 ----LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPG 314
L + + +A V+VVF + F + N+ K+W+AS+ W+ + IT +P
Sbjct: 258 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN-KMWIASDNWSTATKITTIPN 316
Query: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKG----SWCSSNQLCRECQAF 370
+++IG V+G A ++ + +F + + + H+ S C+ + Q
Sbjct: 317 VKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCI 376
Query: 371 MAHTMPKLKAFSMSSA---------------------YNAYRAVYAVAHGLHQLLGCASG 409
H+ L A+ + A ++ AV+A+ + + L C +
Sbjct: 377 FNHSQRTL-AYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDL--CQAR 433
Query: 410 ACSRGRVY-PWQLLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGS 468
C + PW+LL + V F ++ F+ + D + Y+++ W T T +
Sbjct: 434 DCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAE 493
Query: 469 STWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHH-CCFECVPCGAGTF 527
I + + + ++ + +S CS +C G + T H CC+EC C +
Sbjct: 494 YDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHY 553
Query: 528 LNKSDLYRCQPCG-KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAG 586
N++D+ C C K WAP S CF + V +L + + +LL + L ++ +L
Sbjct: 554 TNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGI 613
Query: 587 LFAWHLDTPVVRSAGG-RLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIF 645
+F +L+TPVV+S+GG R+C+++L S F GEP C RQ +F + FT+
Sbjct: 614 IFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLC 673
Query: 646 LSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLP 705
+SC+ +S ++++ F F K+ F + L + + Q++IC WL+ P
Sbjct: 674 ISCILTKSLKILLAFSFDPKLQKFLKCLYRPI---LIIFTCTGIQVVICTLWLIFAAPTV 730
Query: 706 AREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFS 765
P +++LEC E + L F Y +L+ F ++ GK ENYNEAK +TF
Sbjct: 731 EVNVS-LPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFG 787
Query: 766 LLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTE 825
+L F++WI F + GKY+PA ++ L S F+PKCYVI+C+ ++N+
Sbjct: 788 MLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKS 847
Query: 826 HFQASIQDYT 835
F I Y+
Sbjct: 848 AFLKMIYSYS 857
>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
Length = 324
Score = 345 bits (884), Expect = 1e-94
Identities = 166/167 (99%), Positives = 167/167 (100%)
Query: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT
Sbjct: 1 MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVT 60
Query: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS
Sbjct: 61 LCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLS 120
Query: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMI 167
LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPM+
Sbjct: 121 LPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
Score = 248 bits (634), Expect = 1e-65
Identities = 111/111 (100%), Positives = 111/111 (100%)
Query: 421 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 480
LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 226
Query: 481 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKS 531
TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKS
Sbjct: 227 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKS 277
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 259 bits (661), Expect = 9e-69
Identities = 229/846 (27%), Positives = 381/846 (45%), Gaps = 85/846 (10%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+PGD ++ LF +H H+P V + +R C ++G +AM +E IN+
Sbjct: 31 MPGDIIIGALFSVH-------HQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDP 83
Query: 91 ALLPNITLGYQLYDVCSDSANVYAT----LRVLSLPGQHH------IELQGDLLHYSPTV 140
LLPNITLG ++ D C SA +R + + ++ +
Sbjct: 84 TLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPI 143
Query: 141 LAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMV 200
+ VIGP S++ A LL F +P I+Y+A+S LS K + F+R +P+D Q MV
Sbjct: 144 VGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMV 203
Query: 201 LLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA--FKDIMPFSAQVGDERMQC 258
+++++ WT++S V + +YG+ G++A ++ + +GICIA +K Q D+ ++
Sbjct: 204 DIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKK 263
Query: 259 LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITGVPGIQR 317
L HL + A VV F R ++ L G+ + + S+ WA +T G QR
Sbjct: 264 LTSHLPK--ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVT--DGYQR 319
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS----------------- 360
V G+ I+ ++ P +K F++ Y K P H+ W
Sbjct: 320 -EAVGGITIKLQS-PDVKWFDDYYL---KLRPETNHRNPWFQEFWQHRFQCRLEGFPQEN 374
Query: 361 ---NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLH--QLLGCA--SGACSR 413
N+ C H + K M N A+Y++A+GLH Q+ C +G C
Sbjct: 375 SKYNKTCNSSLTLKTHHVQDSK---MGFVIN---AIYSMAYGLHNMQMSLCPGYAGLCDA 428
Query: 414 GR-VYPWQLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTW 471
+ + +LLE + K +F + DT+ F++N D Y I+ + G + F + +W
Sbjct: 429 MKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDY-FDYINVGSW 487
Query: 472 SPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVV-TGFHHCCFECVPCGAGTFLNK 530
+L +++ ++ W K N + +SVCS C +G +V+ G CC+ C PC ++
Sbjct: 488 DNGELKMDDDEV-WSKKSN-IIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYV-- 543
Query: 531 SDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAW 590
D Y C+ C W + C V +L + + L LL L +F
Sbjct: 544 FDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFII 603
Query: 591 HLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLT 650
+ DTPVV+S+ LC+++L + G + +P + C L++ L + S L
Sbjct: 604 YRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALV 663
Query: 651 VRSFQLIIIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLP 705
++ ++ I K TK P F A Q A + + I QL I + ++ P
Sbjct: 664 TKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICI----QLGIIVALFIMEPPDI 719
Query: 706 AREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFS 765
+Y V L C TN LG + YNGLL +S ++ +++P N+NEAK + F+
Sbjct: 720 MHDYPSIRE-VYLICNTTN-LGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFT 777
Query: 766 LLFNFVSWIAFFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLNST 824
+ + W+AF +Y G M +S S + G F+PK Y+IL +P+ N
Sbjct: 778 MYTTCIIWLAF---VPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834
Query: 825 EHFQAS 830
F S
Sbjct: 835 SAFTTS 840
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 259 bits (661), Expect = 9e-69
Identities = 229/846 (27%), Positives = 381/846 (45%), Gaps = 85/846 (10%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+PGD ++ LF +H H+P V + +R C ++G +AM +E IN+
Sbjct: 31 MPGDIIIGALFSVH-------HQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDP 83
Query: 91 ALLPNITLGYQLYDVCSDSANVYAT----LRVLSLPGQHH------IELQGDLLHYSPTV 140
LLPNITLG ++ D C SA +R + + ++ +
Sbjct: 84 TLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPI 143
Query: 141 LAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMV 200
+ VIGP S++ A LL F +P I+Y+A+S LS K + F+R +P+D Q MV
Sbjct: 144 VGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMV 203
Query: 201 LLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIA--FKDIMPFSAQVGDERMQC 258
+++++ WT++S V + +YG+ G++A ++ + +GICIA +K Q D+ ++
Sbjct: 204 DIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKK 263
Query: 259 LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITGVPGIQR 317
L HL + A VV F R ++ L G+ + + S+ WA +T G QR
Sbjct: 264 LTSHLPK--ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVT--DGYQR 319
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSS----------------- 360
V G+ I+ ++ P +K F++ Y K P H+ W
Sbjct: 320 -EAVGGITIKLQS-PDVKWFDDYYL---KLRPETNHRNPWFQEFWQHRFQCRLEGFPQEN 374
Query: 361 ---NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLH--QLLGCA--SGACSR 413
N+ C H + K M N A+Y++A+GLH Q+ C +G C
Sbjct: 375 SKYNKTCNSSLTLKTHHVQDSK---MGFVIN---AIYSMAYGLHNMQMSLCPGYAGLCDA 428
Query: 414 GR-VYPWQLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTW 471
+ + +LLE + K +F + DT+ F++N D Y I+ + G + F + +W
Sbjct: 429 MKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDY-FDYINVGSW 487
Query: 472 SPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVV-TGFHHCCFECVPCGAGTFLNK 530
+L +++ ++ W K N + +SVCS C +G +V+ G CC+ C PC ++
Sbjct: 488 DNGELKMDDDEV-WSKKSN-IIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYV-- 543
Query: 531 SDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAW 590
D Y C+ C W + C V +L + + L LL L +F
Sbjct: 544 FDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFII 603
Query: 591 HLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLT 650
+ DTPVV+S+ LC+++L + G + +P + C L++ L + S L
Sbjct: 604 YRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALV 663
Query: 651 VRSFQLIIIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLP 705
++ ++ I K TK P F A Q A + + I QL I + ++ P
Sbjct: 664 TKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICI----QLGIIVALFIMEPPDI 719
Query: 706 AREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFS 765
+Y V L C TN LG + YNGLL +S ++ +++P N+NEAK + F+
Sbjct: 720 MHDYPSIRE-VYLICNTTN-LGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFT 777
Query: 766 LLFNFVSWIAFFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLNST 824
+ + W+AF +Y G M +S S + G F+PK Y+IL +P+ N
Sbjct: 778 MYTTCIIWLAF---VPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834
Query: 825 EHFQAS 830
F S
Sbjct: 835 SAFTTS 840
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 255 bits (651), Expect = 1e-67
Identities = 222/842 (26%), Positives = 384/842 (45%), Gaps = 74/842 (8%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
Query: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
Query: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
Query: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
Query: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGL----HQLLGCASGACSRGR-VY 417
+ K S Y A+YA+AHGL H L G C + +
Sbjct: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPID 446
Query: 418 PWQLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDW-NGPKWTFTVLGSSTWSPVQ 475
+LL+ + K F+ + + V F++ D Y+I+ + ++ + +G TW
Sbjct: 447 GSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVG--TWHEGV 504
Query: 476 LNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVV-TGFHHCCFECVPCGAGTFLNKSDLY 534
LNI++ KIQ + + V +SVCS CL+G +V+ G CC+ C C ++ D +
Sbjct: 505 LNIDDYKIQMN--KSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYV--QDEF 560
Query: 535 RCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDT 594
C+ C W C P V +L S + +A + L +L+ L +F + DT
Sbjct: 561 TCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDT 620
Query: 595 PVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSF 654
PVV+S+ LC+++L + G + +PT +C L++ L L + S L ++
Sbjct: 621 PVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTN 680
Query: 655 QLIIIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREY 709
++ I K T+ P F AW Q A + + + QL + +T +++ P+P Y
Sbjct: 681 RIARILAGSKKKICTRKPRFMSAWAQVIIASILISV----QLTLVVTLIIMEPPMPILSY 736
Query: 710 QRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFN 769
+ ++ T++LG + YNGLL +S ++ +++P N+NEAK + F++
Sbjct: 737 PSIKEVYLI--CNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTT 794
Query: 770 FVSWIAFFTTASVYDG-KYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQ 828
+ W+AF +Y G Y A S++ G F PK Y+I+ +P+ N F
Sbjct: 795 CIIWLAF---VPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFT 851
Query: 829 AS 830
S
Sbjct: 852 TS 853
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 255 bits (651), Expect = 1e-67
Identities = 222/842 (26%), Positives = 384/842 (45%), Gaps = 74/842 (8%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVT-LCDRSCSF--NEHGYHLFQAMRLGVEEINNST 90
+ GD ++ LF +H H+P + +R C ++G +AM +++IN
Sbjct: 41 MDGDVIIGALFSVH-------HQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADP 93
Query: 91 ALLPNITLGYQLYDVCSDSANV------YATLRVLSL----PGQHHIELQGDLLHYSPT- 139
LLPNITLG ++ D C S+ + ++S+ G + G L T
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 140 --VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVE 197
+ VIGP S++ A LL F +P I+Y+A+S LS K Y FLR +P+D Q
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 198 TMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ 257
M+ +++++ WT++S V + +YG+ G+ A + A +G+CIA D + G++
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSD--KIYSNAGEKSFD 271
Query: 258 CLMRHLAQ--AGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPG 314
L+R L + A VVV F R ++ + G+ + S+ WA +
Sbjct: 272 RLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYE 331
Query: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAY--ARADKKAPRPCHKGSWCSSNQLCRECQAFMA 372
++ G G+ I+ ++ P +++F++ + R D P W Q CR +
Sbjct: 332 VEANG---GITIKLQS-PEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQ-CRLPGHLLE 386
Query: 373 HTMPKLKAFSMSSAYNAY----------RAVYAVAHGL----HQLLGCASGACSRGR-VY 417
+ K S Y A+YA+AHGL H L G C + +
Sbjct: 387 NPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPID 446
Query: 418 PWQLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDW-NGPKWTFTVLGSSTWSPVQ 475
+LL+ + K F+ + + V F++ D Y+I+ + ++ + +G TW
Sbjct: 447 GSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVG--TWHEGV 504
Query: 476 LNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVV-TGFHHCCFECVPCGAGTFLNKSDLY 534
LNI++ KIQ + + V +SVCS CL+G +V+ G CC+ C C ++ D +
Sbjct: 505 LNIDDYKIQMN--KSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYV--QDEF 560
Query: 535 RCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDT 594
C+ C W C P V +L S + +A + L +L+ L +F + DT
Sbjct: 561 TCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDT 620
Query: 595 PVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSF 654
PVV+S+ LC+++L + G + +PT +C L++ L L + S L ++
Sbjct: 621 PVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTN 680
Query: 655 QLIIIF-----KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREY 709
++ I K T+ P F AW Q A + + + QL + +T +++ P+P Y
Sbjct: 681 RIARILAGSKKKICTRKPRFMSAWAQVIIASILISV----QLTLVVTLIIMEPPMPILSY 736
Query: 710 QRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFN 769
+ ++ T++LG + YNGLL +S ++ +++P N+NEAK + F++
Sbjct: 737 PSIKEVYLI--CNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTT 794
Query: 770 FVSWIAFFTTASVYDG-KYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQ 828
+ W+AF +Y G Y A S++ G F PK Y+I+ +P+ N F
Sbjct: 795 CIIWLAF---VPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFT 851
Query: 829 AS 830
S
Sbjct: 852 TS 853
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 245 bits (625), Expect = 1e-64
Identities = 228/845 (26%), Positives = 368/845 (43%), Gaps = 93/845 (11%)
Query: 34 LPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALL 93
+ GD L GLFP+H + + E+ E G H +AM ++ INN LL
Sbjct: 45 IDGDITLGGLFPVHGRGSEGKPCGELK--------KEKGIHRLEAMLFALDRINNDPDLL 96
Query: 94 PNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGD----------LLHYSPTVLAV 143
PNITLG ++ D CS + +A + L+ Q IE G ++ V+ V
Sbjct: 97 PNITLGARILDTCS--RDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGV 153
Query: 144 IGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLL 203
IG ++ + A +L F +P ISYA+++ LS +Y F R +P+D YQ + MV ++
Sbjct: 154 IGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIV 213
Query: 204 QKFGWTWISLVGSSDDYGQLGVQA-LENQATGQGICIAFKDIMPFSAQVGDERMQCLMRH 262
+ W ++S V S YG+ GV+A ++ G+CIA +P + G E + + R
Sbjct: 214 RALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAG-EFDKIIRRL 272
Query: 263 LAQAGATVVVVFSSRQLARVFFESVVLTNLTGKV-WVASEAWALSRHITGVPGIQRIGMV 321
L + A V++F++ R E+ N TG W+ S++W I V ++ +
Sbjct: 273 LETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSK--IAPVLHLEEVAEG 330
Query: 322 LGVAIQKRAVPGLKAFEEAYA-RADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPK--- 377
+ KR ++ F+ ++ R R + N C+ H + K
Sbjct: 331 AVTILPKRM--SVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCK----LSRHALKKGSH 384
Query: 378 ------LKAFSMSSAYN-------AYRAVYAVAHGLH----QLLGCASGACSR-GRVYPW 419
+ SAY AVYA+ H LH L G C R V
Sbjct: 385 VKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGT 444
Query: 420 QLLEQIHKVHFL-LHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNI 478
QLL+ I V+F + + V FN+N D Y+I + + V+GS W+ L++
Sbjct: 445 QLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGS--WTD-HLHL 501
Query: 479 NETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQP 538
++ W G Q+P+S+CS C G ++ CC+ C PC + + D Y C+
Sbjct: 502 RIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTG--YQYQVDRYTCKT 559
Query: 539 CGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAG------LFAWHL 592
C + E C R + + L + W +L L L ++G A F +
Sbjct: 560 CPYDMRPTENRTGC--RPIPIIKLEWGSPWAVLP----LFLAVVGIAATLFVVITFVRYN 613
Query: 593 DTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVR 652
DTP+V+++G L +++L + + + EP C LR+ LG +I + L +
Sbjct: 614 DTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTK 673
Query: 653 SFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREY 709
+ ++ IF K S P F Q A F +IS QLL W VV ++
Sbjct: 674 TNRIYRIFEQGKRSVSAPRFISPASQL--AITFSLIS--LQLLGICVWFVVDPSHSVVDF 729
Query: 710 Q-------RFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCV 762
Q RF V L+C + + L I Y+ LL ++ + + +PE +NEAK +
Sbjct: 730 QDQRTLDPRFARGV-LKC-DISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPI 787
Query: 763 TFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILC 817
F++ + W+A FF T+ D Y+ + +S S S G ++PK Y+IL
Sbjct: 788 GFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILF 847
Query: 818 RPDLN 822
P+ N
Sbjct: 848 HPEQN 852
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 235 bits (599), Expect = 1e-61
Identities = 230/842 (27%), Positives = 358/842 (42%), Gaps = 88/842 (10%)
Query: 33 TLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCS-FNEH-GYHLFQAMRLGVEEINNST 90
TL GD +L GLFP+H + P C NEH G +AM ++ IN
Sbjct: 27 TLEGDLVLGGLFPVHQ-----KGGPA-----EDCGPVNEHRGIQRLEAMLFALDRINRDP 76
Query: 91 ALLPNITLGYQLYDVCSDSAN--------VYATLRVLSLPGQHHIELQGDLLHY--SPTV 140
LLP + LG + D CS + V A+L G HI G + +PT
Sbjct: 77 HLLPGVRLGAHILDSCSKDTHALEQALDFVRASLS-RGADGSRHICPDGSYATHGDAPTA 135
Query: 141 LA-VIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
+ VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D +Q + M
Sbjct: 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM 195
Query: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCL 259
+L+ F WT++S V S DYG+ G++A E +A + IC+A + + + +
Sbjct: 196 AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSE--KVGRAMSRAAFEGV 253
Query: 260 MRHLAQ-AGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAW-ALSRHITGVPGIQR 317
+R L Q A V V+F+ + AR + N WVAS+ W AL + G G
Sbjct: 254 VRALLQKPSARVAVLFTRSEDARELLAASQRLN-ASFTWVASDGWGALESVVAGSEGAAE 312
Query: 318 IGMVLGVAIQKRAVPGLKAFEEAYARAD--KKAPRPCHKGSW-----CSSNQLCRECQAF 370
+ + +A + F + D + P + W CS Q R+C A
Sbjct: 313 GAITIELASYP-----ISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--RDCAAH 365
Query: 371 MAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVH- 429
+P + + N AVYA+AH LH + +R L + + V+
Sbjct: 366 SLRAVPFEQESKIMFVVN---AVYAMAHALHNMHRALCPNTTR-------LCDAMRPVNG 415
Query: 430 FLLHKD---TVAFNDNRDPLSSYNIIAWDWNGPK------WTFTVLGSSTWSPVQ----- 475
L+KD V F+ P ++N + +D G +T+ GS + +
Sbjct: 416 RRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWA 475
Query: 476 --LNINETKIQWHGKD-NQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSD 532
L ++ + I W +P S CS CL+ + V CC+ C+PC + + D
Sbjct: 476 EGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEY--RLD 533
Query: 533 LYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL--LAANTLLLLLLLGTAGLFAW 590
+ C CG W CF + +R +W + + L L L G+F
Sbjct: 534 EFTCADCGLGYWPNASLTGCFELPQEY--IRWGDAWAVGPVTIACLGALATLFVLGVFVR 591
Query: 591 HLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLT 650
H TPVV+++G LC+++LG + + F +P+ C LR+ F++ S L
Sbjct: 592 HNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALL 651
Query: 651 VRSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAR 707
++ ++ IF + + P F + A +IS QLLI + WLVV P +
Sbjct: 652 TKTNRIARIFGGAREGAQRPRFISP--ASQVAICLALIS--GQLLIVVAWLVVEAPGTGK 707
Query: 708 E-YQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSL 766
E +V L C ++ + + YN LL ++ + PEN+NEAK + F++
Sbjct: 708 ETAPERREVVTLRCNHRDA-SMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTM 766
Query: 767 LFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSG--FGGYFLPKCYVILCRPDLNST 824
+ W+AF V Y M SLS G F PK ++IL +P N
Sbjct: 767 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVV 826
Query: 825 EH 826
H
Sbjct: 827 SH 828
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 229 bits (585), Expect = 6e-60
Identities = 219/859 (25%), Positives = 358/859 (41%), Gaps = 116/859 (13%)
Query: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNE-HGYHLFQAMRLGVEEINNS 89
+ + GD +L GLFP++ + T + NE G +AM ++EIN
Sbjct: 32 EIKIEGDLVLGGLFPINE---------KGTGTEECGRINEDRGIQRLEAMLFAIDEINKD 82
Query: 90 TALLPNITLGYQLYDVCSDSANVYATLRVLSL----------------PGQHHIELQGDL 133
LLP + LG + D CS + YA + L G + I+ L
Sbjct: 83 DYLLPGVKLGVHILDTCS--RDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPL 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
L + VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D
Sbjct: 141 L-----IAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF 195
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGD 253
YQ + M +L+ F WT++S V S DYG+ G++A E +A + ICIA + + S +
Sbjct: 196 YQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRS-NIRK 254
Query: 254 ERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVP 313
+ L + A VVV+F +R + N WVAS+ W I +
Sbjct: 255 SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESI--IK 311
Query: 314 GIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSW----------CS---S 360
G + + G + A ++ F+ + + P H+ W CS
Sbjct: 312 GSEHV--AYGAITLELASQPVRQFDRYFQSLN---PYNNHRNPWFRDFWEQKFQCSLQNK 366
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQ----LLGCASGACSRGRV 416
R C +A + S AVYA+AH LH+ L + C ++
Sbjct: 367 RNHRRVCDKHLAIDSSNYE--QESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKI 424
Query: 417 YPWQLLEQIHKVHFLLHKDTVAFNDNRDP------------LSSYNIIAWDWNGPKWTFT 464
++++K + L T FN N+D + YN+ + G K+++
Sbjct: 425 LDG---KKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYL 481
Query: 465 VLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGA 524
+G W+ L+++ I W N VP S CS C + + CC+ C+PC
Sbjct: 482 KVGH--WAET-LSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEP 536
Query: 525 GTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL--LAANTLLLLLLL 582
+L +D + C CG +W C+ + +R +W + + L +
Sbjct: 537 YEYL--ADEFTCMDCGSGQWPTADLTGCYDLPEDY--IRWEDAWAIGPVTIACLGFMCTC 592
Query: 583 GTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGF 642
+F H +TP+V+++G LC+++L + + F +P+ C LR+ F
Sbjct: 593 MVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSF 652
Query: 643 TIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLV--- 699
I S L ++ + IF V+N GA IS ++Q+ ICL ++
Sbjct: 653 AICYSALLTKTNCIARIFD-----------GVKN-GAQRPKFISPSSQVFICLGLILVQI 700
Query: 700 ----VWTPLPAREYQRFP-----HLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGK 750
VW L A +R+ V+L+C +S +++ Y+ +L I ++ +
Sbjct: 701 VMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDS-SMLISLTYDVILVILCTVYAFKTR 759
Query: 751 DLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGF---GGY 807
PEN+NEAK + F++ + W+AF V Y M +S SGF G
Sbjct: 760 KCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC-ISVSLSGFVVLGCL 818
Query: 808 FLPKCYVILCRPDLNSTEH 826
F PK ++IL +P N H
Sbjct: 819 FAPKVHIILFQPQKNVVTH 837
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 224 bits (572), Expect = 2e-58
Identities = 226/876 (25%), Positives = 371/876 (42%), Gaps = 101/876 (11%)
Query: 11 LQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSF-- 68
L L+ W ++ L G L GLFP+H+ R+C
Sbjct: 12 LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHAR----------GAAGRACGQLK 61
Query: 69 NEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE 128
E G H +AM ++ +N LLP + LG +L D CS + YA + LS Q I
Sbjct: 62 KEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCS--RDTYALEQALSFV-QALIR 118
Query: 129 LQGD-------------LLHYSPT--VLAVIGPDSTNRAATTAALLSPFLVPMISYAASS 173
+GD L +P V+AV+G +++ + A +L F +P ISYA+++
Sbjct: 119 GRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTA 178
Query: 174 ETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQA-LENQA 232
LS +Y F R +P D YQ + MV +++ GW ++S + S +YG+ GV+A ++
Sbjct: 179 PELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISR 238
Query: 233 TGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNL 292
G+CIA +P + G E + + R + A +++F++ R E+ NL
Sbjct: 239 EAGGVCIAQSIKIPREPKPG-EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANL 297
Query: 293 TGK-VWVASEAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAY-ARADKKAPR 350
TG +WV S++W + + ++ + + + KRA + F++ + R+ + R
Sbjct: 298 TGHFLWVGSDSWGAKT--SPILSLEDVAVGAITILPKRA--SIDGFDQYFMTRSLENNRR 353
Query: 351 PCHKGSWCSSNQLCRECQAFMAHTMPKLKA-----FSMSSAYN-------AYRAVYAVAH 398
+ N C+ + K S Y AVYA+AH
Sbjct: 354 NIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAH 413
Query: 399 GLHQLLGCA----SGAC-----SRGRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSS 448
LH + +G C + GR+ LL+ I V F T V FN+N D
Sbjct: 414 ALHSMHQALCPGHTGLCPAMEPTDGRM----LLQYIRAVRFNGSAGTPVMFNENGDAPGR 469
Query: 449 YNIIAWD-WNGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQR 507
Y+I + NG + W+ L ++ +QW G ++VP S+CS C G ++
Sbjct: 470 YDIFQYQATNGSASSGGYQAVGQWAET-LRLDVEALQWSGDPHEVPSSLCSLPCGPGERK 528
Query: 508 VVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTS 567
+ CC+ C C F + D + C+ C + C P VV L S
Sbjct: 529 KMVKGVPCCWHCEACDGYRF--QVDEFTCEACPGDMRPTPNHTGCRPTPVVRL------S 580
Query: 568 WVLLAANTLLLLLLLG------TAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYG 621
W A LLL +LG F + +TP+VR++G L +++L + +
Sbjct: 581 WSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFL 640
Query: 622 FFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHG 678
EP C R+ LG T+ S L ++ ++ IF K S P F Q
Sbjct: 641 MVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQ--- 697
Query: 679 AGLFVMIS-SAAQLLICLTWLVVWTPLPAREYQRFPHL------VMLECTETNSLGFILA 731
L + S ++ Q++ + WL P +Y+ + +L+C + + L I
Sbjct: 698 --LVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKC-DMSDLSLIGC 754
Query: 732 FLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKY 787
Y+ LL ++ + + +PE +NEAK + F++ + W+A FF TA + Y
Sbjct: 755 LGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIY 814
Query: 788 LPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLN 822
+ + LS S S G ++PK YVIL P+ N
Sbjct: 815 IQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQN 850
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 218 bits (556), Expect = 1e-56
Identities = 216/852 (25%), Positives = 363/852 (42%), Gaps = 88/852 (10%)
Query: 24 HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83
HS E + + GD +L GLFP+H+ + E+ E G H +AM +
Sbjct: 32 HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
Query: 84 EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133
++IN LL NITLG ++ D CS + YA + L+ Q IE GD +
Sbjct: 84 DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
+ VIG +++ + A +L F +P ISYA+++ LS +Y F R +P D
Sbjct: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252
YQ + MV ++ GW ++S + S +YG+ GV+A + G+CIA +P + G
Sbjct: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
Query: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITG 311
E + + R L A V++F++ R E+ N +G +W+ S++W I
Sbjct: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW--GSKIAP 317
Query: 312 VPGIQRIGMVLGVAIQKRA-VPGLKAFEEAYARADKK----------APRPCHKGSWCSS 360
V + I + KRA + G + + A+ + C GS
Sbjct: 318 VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKR 377
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYN-------AYRAVYAVAHGLH----QLLGCASG 409
N ++C L+ + S+Y AVY++A+ LH L G
Sbjct: 378 NSHIKKCTG--------LERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIG 429
Query: 410 ACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDWNGPKWTFTVLG 467
C R + +LL I V+F T V FN+N D Y+I + + V+G
Sbjct: 430 LCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIG 489
Query: 468 SSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTF 527
T QL++ +QW +++ P SVCS C G ++ CC+ C C +
Sbjct: 490 HWT---NQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNY 546
Query: 528 LNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGL 587
+ D C+ C ++ C + + + L H+ W ++ +L ++ T +
Sbjct: 547 --QVDELSCELCPLDQRPNMNRTGC--QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVI 602
Query: 588 --FAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIF 645
F + DTP+VR++G L +++L + + P C R+ LG
Sbjct: 603 VTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFS 662
Query: 646 LSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMIS-SAAQLLICLTWLVVW 701
+ L ++ ++ IF K S P F + + L + S + QLL W VV
Sbjct: 663 YAALLTKTNRIHRIFEQGKKSVTAPKFI-----SPASQLVITFSLISVQLLGVFVWFVVD 717
Query: 702 TPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPEN 755
P +Y L +L+C + + L I + Y+ LL ++ + + +PE
Sbjct: 718 PPHIIIDYGEQRTLDPEKARGVLKC-DISDLSLICSLGYSILLMVTCTVYAIKTRGVPET 776
Query: 756 YNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLP 810
+NEAK + F++ + W+A FF TA + Y+ + +S S S G ++P
Sbjct: 777 FNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMP 836
Query: 811 KCYVILCRPDLN 822
K Y+I+ P+ N
Sbjct: 837 KVYIIIFHPEQN 848
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 218 bits (556), Expect = 1e-56
Identities = 216/852 (25%), Positives = 363/852 (42%), Gaps = 88/852 (10%)
Query: 24 HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83
HS E + + GD +L GLFP+H+ + E+ E G H +AM +
Sbjct: 32 HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
Query: 84 EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133
++IN LL NITLG ++ D CS + YA + L+ Q IE GD +
Sbjct: 84 DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
Query: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
+ VIG +++ + A +L F +P ISYA+++ LS +Y F R +P D
Sbjct: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
Query: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252
YQ + MV ++ GW ++S + S +YG+ GV+A + G+CIA +P + G
Sbjct: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
Query: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITG 311
E + + R L A V++F++ R E+ N +G +W+ S++W I
Sbjct: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW--GSKIAP 317
Query: 312 VPGIQRIGMVLGVAIQKRA-VPGLKAFEEAYARADKK----------APRPCHKGSWCSS 360
V + I + KRA + G + + A+ + C GS
Sbjct: 318 VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKR 377
Query: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYN-------AYRAVYAVAHGLH----QLLGCASG 409
N ++C L+ + S+Y AVY++A+ LH L G
Sbjct: 378 NSHIKKCTG--------LERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIG 429
Query: 410 ACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDWNGPKWTFTVLG 467
C R + +LL I V+F T V FN+N D Y+I + + V+G
Sbjct: 430 LCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIG 489
Query: 468 SSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTF 527
T QL++ +QW +++ P SVCS C G ++ CC+ C C +
Sbjct: 490 HWT---NQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNY 546
Query: 528 LNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGL 587
+ D C+ C ++ C + + + L H+ W ++ +L ++ T +
Sbjct: 547 --QVDELSCELCPLDQRPNMNRTGC--QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVI 602
Query: 588 --FAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIF 645
F + DTP+VR++G L +++L + + P C R+ LG
Sbjct: 603 VTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFS 662
Query: 646 LSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMIS-SAAQLLICLTWLVVW 701
+ L ++ ++ IF K S P F + + L + S + QLL W VV
Sbjct: 663 YAALLTKTNRIHRIFEQGKKSVTAPKFI-----SPASQLVITFSLISVQLLGVFVWFVVD 717
Query: 702 TPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPEN 755
P +Y L +L+C + + L I + Y+ LL ++ + + +PE
Sbjct: 718 PPHIIIDYGEQRTLDPEKARGVLKC-DISDLSLICSLGYSILLMVTCTVYAIKTRGVPET 776
Query: 756 YNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLP 810
+NEAK + F++ + W+A FF TA + Y+ + +S S S G ++P
Sbjct: 777 FNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMP 836
Query: 811 KCYVILCRPDLN 822
K Y+I+ P+ N
Sbjct: 837 KVYIIIFHPEQN 848
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 202 bits (515), Expect = 8e-52
Identities = 210/865 (24%), Positives = 361/865 (41%), Gaps = 88/865 (10%)
Query: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71
++ C A A E + + GD L GLFP+H+ P C E+
Sbjct: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129
Query: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179
D T V+ VIG ++ + A +L F +P ISYA+++ LS
Sbjct: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189
Query: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALEN-QATGQGIC 238
R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ G+C
Sbjct: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249
Query: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296
IA +P + +++ L + VV+F++ + + + + G +
Sbjct: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309
Query: 297 WVASEAWA-----LSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRP 351
WV S++W L +H G + + ++ V G A+ + + + R
Sbjct: 310 WVGSDSWGSKINPLHQHEDIAEG------AITIQPKRATVEGFDAYFTSRTLENNR--RN 361
Query: 352 CHKGSWCSSNQLC-------------RECQAFMAHTMPKLKAFSMSSAYN-AYRAVYAVA 397
+ N C R+C + K + AVYA+A
Sbjct: 362 VWFAEYWEENFNCKLTISGSKKEDTDRKCTG--QERIGKDSNYEQEGKVQFVIDAVYAMA 419
Query: 398 HGLHQLLG--CAS--GACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNI 451
H LH + CA G C + +LL+ I V+F T V FN N D Y+I
Sbjct: 420 HALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDI 479
Query: 452 IAWDW-NGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVT 510
+ N + ++G T +QLNI + +QW ++P SVC+ C G ++
Sbjct: 480 FQYQTTNTSNPGYRLIGQWT-DELQLNIED--MQWGKGVREIPASVCTLPCKPGQRKKTQ 536
Query: 511 GFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL 570
CC+ C PC + + D CQ C ++ E C + + + L H+ W +
Sbjct: 537 KGTPCCWTCEPCDG--YQYQFDEMTCQHCPYDQRPNENRTGC--QDIPIIKLEWHSPWAV 592
Query: 571 LAANTLLL--LLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTR 628
+ +L + + F + DTP+VR++G L +++L + + +P
Sbjct: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652
Query: 629 PACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSA 688
C R+ LG I + L ++ ++ IF+ K T + + S
Sbjct: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLIS- 711
Query: 689 AQLLICLTWLVVWTPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISA 742
QLL W V P +Y + +L+C T+ L I + Y+ LL ++
Sbjct: 712 VQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITD-LQIICSLGYSILLMVTC 770
Query: 743 FACSYLGKDLPENYNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS 798
+ + +PEN+NEAK + F++ + W+A FF TA + Y+ + ++
Sbjct: 771 TVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMN 830
Query: 799 -SLSSGFGGYFLPKCYVILCRPDLN 822
S S G ++PK Y+I+ P+LN
Sbjct: 831 LSASVALGMLYMPKVYIIIFHPELN 855
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 202 bits (515), Expect = 8e-52
Identities = 210/865 (24%), Positives = 361/865 (41%), Gaps = 88/865 (10%)
Query: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71
++ C A A E + + GD L GLFP+H+ P C E+
Sbjct: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q
Sbjct: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129
Query: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179
D T V+ VIG ++ + A +L F +P ISYA+++ LS
Sbjct: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189
Query: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALEN-QATGQGIC 238
R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ G+C
Sbjct: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249
Query: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296
IA +P + +++ L + VV+F++ + + + + G +
Sbjct: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309
Query: 297 WVASEAWA-----LSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRP 351
WV S++W L +H G + + ++ V G A+ + + + R
Sbjct: 310 WVGSDSWGSKINPLHQHEDIAEG------AITIQPKRATVEGFDAYFTSRTLENNR--RN 361
Query: 352 CHKGSWCSSNQLC-------------RECQAFMAHTMPKLKAFSMSSAYN-AYRAVYAVA 397
+ N C R+C + K + AVYA+A
Sbjct: 362 VWFAEYWEENFNCKLTISGSKKEDTDRKCTG--QERIGKDSNYEQEGKVQFVIDAVYAMA 419
Query: 398 HGLHQLLG--CAS--GACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNI 451
H LH + CA G C + +LL+ I V+F T V FN N D Y+I
Sbjct: 420 HALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDI 479
Query: 452 IAWDW-NGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVT 510
+ N + ++G T +QLNI + +QW ++P SVC+ C G ++
Sbjct: 480 FQYQTTNTSNPGYRLIGQWT-DELQLNIED--MQWGKGVREIPASVCTLPCKPGQRKKTQ 536
Query: 511 GFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL 570
CC+ C PC + + D CQ C ++ E C + + + L H+ W +
Sbjct: 537 KGTPCCWTCEPCDG--YQYQFDEMTCQHCPYDQRPNENRTGC--QDIPIIKLEWHSPWAV 592
Query: 571 LAANTLLL--LLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTR 628
+ +L + + F + DTP+VR++G L +++L + + +P
Sbjct: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652
Query: 629 PACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSA 688
C R+ LG I + L ++ ++ IF+ K T + + S
Sbjct: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLIS- 711
Query: 689 AQLLICLTWLVVWTPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISA 742
QLL W V P +Y + +L+C T+ L I + Y+ LL ++
Sbjct: 712 VQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITD-LQIICSLGYSILLMVTC 770
Query: 743 FACSYLGKDLPENYNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS 798
+ + +PEN+NEAK + F++ + W+A FF TA + Y+ + ++
Sbjct: 771 TVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMN 830
Query: 799 -SLSSGFGGYFLPKCYVILCRPDLN 822
S S G ++PK Y+I+ P+LN
Sbjct: 831 LSASVALGMLYMPKVYIIIFHPELN 855
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/211 (27%), Positives = 90/211 (42%), Gaps = 11/211 (5%)
Query: 622 FFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHG 678
F +P+ C LR+ F++ S L ++ ++ IF + + P F Q
Sbjct: 5 FIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQV-- 62
Query: 679 AGLFVMISSAAQLLICLTWLVVWTPLPAREYQ-RFPHLVMLECTETNSLGFILAFLYNGL 737
A +IS QLLI + WLVV P +E +V L C ++ + + YN L
Sbjct: 63 AICLALISG--QLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDA-SMLGSLAYNVL 119
Query: 738 LSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGL 797
L ++ + PEN+NEAK + F++ + W+AF V Y M
Sbjct: 120 LIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVS 179
Query: 798 SSLSSG--FGGYFLPKCYVILCRPDLNSTEH 826
SLS G F PK ++IL +P N H
Sbjct: 180 VSLSGSVVLGCLFAPKLHIILFQPQKNVVSH 210
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 55.5 bits (132), Expect = 2e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 129 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 174
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 175 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 232
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 233 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 288
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 289 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 327
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 55.5 bits (132), Expect = 2e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 74 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 119
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 120 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 177
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 178 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 233
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 234 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 272
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 55.5 bits (132), Expect = 2e-07
Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 24/222 (10%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYS 137
A+ + +E++N+ +LP+ L +D D PGQ L +LL+
Sbjct: 191 AVEMALEDVNSRRDILPDYELKLIHHDSKCD-------------PGQATKYLY-ELLYND 236
Query: 138 PT-VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
P ++ + G S + AA + +V +SY +SS LS ++++P+F RT P+
Sbjct: 237 PIKIILMPGCSSVSTLVAEAARMWNLIV--LSYGSSSPALSNRQRFPTFFRTHPSATLHN 294
Query: 197 ETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERM 256
T V L +K+GW I+ + + + + LE + GI I F+ V
Sbjct: 295 PTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVP---- 350
Query: 257 QCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWV 298
+++L + A ++V AR F V L GK +V
Sbjct: 351 ---VKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYV 389
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 53.1 bits (126), Expect = 1e-06
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 15/137 (10%)
Query: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131
G + A+ L +E+I N + L P L +LYD D+A ++
Sbjct: 74 GRGVLPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAK--------------GLKAFY 118
Query: 132 DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPN 191
D + Y P L V G + + A L + + +S+AA++ L+ K++YP F RT+P+
Sbjct: 119 DAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPS 178
Query: 192 DKYQVETMVLLLQKFGW 208
D ++ LL+ + W
Sbjct: 179 DNAVNPAILKLLKHYQW 195
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 10/163 (6%)
Query: 162 FLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYG 221
+ +P++ S K + SFLRT+P +Q +++ + W I L+ S D G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 222 QLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLAR 281
+ + LE + + ++ F G + + L+ + A V+++ +S A
Sbjct: 174 RAAQKRLETLLEERE--SKAEKVLQFDP--GTKNVTALLMEAKELEARVIILSASEDDAA 229
Query: 282 VFFESVVLTNLTGK--VWVASE----AWALSRHITGVPGIQRI 318
+ + + N+TG VW+ E AL G+ G+Q I
Sbjct: 230 TVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLI 272
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 40.4 bits (93), Expect = 0.007
Identities = 36/143 (25%), Positives = 59/143 (41%), Gaps = 22/143 (15%)
Query: 78 AMRLGVEEINNSTALLPNITLGYQL-YDVCSDSANVYATLRVLSLPGQHHIELQGDLLHY 136
A RL +E IN P+ L Y Y + ++ T R LS HH G
Sbjct: 75 AARLAIERINRD----PSFDLSYSFEYVILNEDCQ---TSRALSSFISHHQMASG----- 122
Query: 137 SPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQV 196
IGP + + L + + + S+A + L K YP+F RT+P+ +
Sbjct: 123 ------FIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPS---PI 173
Query: 197 ETMVLLLQKFGWTWISLVGSSDD 219
+V +++ F W ++ S +D
Sbjct: 174 RVLVTVMKYFQWAHAGVISSDED 196
>gi|33356136 hypothetical protein LOC222223 isoform 2 [Homo sapiens]
Length = 789
Score = 39.3 bits (90), Expect = 0.015
Identities = 14/35 (40%), Positives = 21/35 (60%)
Query: 518 ECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTC 552
EC PC GTF NK + CQ C + ++ +G++ C
Sbjct: 49 ECFPCKPGTFSNKPGSFNCQVCPRNTYSEKGAKEC 83
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.137 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,465,179
Number of Sequences: 37866
Number of extensions: 1460267
Number of successful extensions: 4554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 4340
Number of HSP's gapped (non-prelim): 153
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.