Search of human proteins with 29029593

Search of human proteins with 29029593

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|29029593 eukaryotic translation initiation factor 2C, 4
[Homo sapiens]
         (861 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo...  1763   0.0  
gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo ...  1475   0.0  
gi|29294647 eukaryotic translation initiation factor 2C, 3 isofo...  1436   0.0  
gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo...  1402   0.0  
gi|29337286 eukaryotic translation initiation factor 2C, 3 isofo...  1125   0.0  
gi|66346725 piwi-like 1 [Homo sapiens]                                159   1e-38
gi|221316711 piwi-like 4 [Homo sapiens]                               154   3e-37
gi|209180418 piwi-like 2 [Homo sapiens]                               143   8e-34
gi|24431985 piwi-like 2 [Homo sapiens]                                143   8e-34
gi|153792298 piwi-like 3 [Homo sapiens]                               135   2e-31
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]    35   0.30 
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]                 31   4.3  
gi|87299628 biorientation of chromosomes in cell division 1-like...    31   4.3  
gi|223029422 SKI-like isoform 3 [Homo sapiens]                         31   5.6  
gi|223029420 SKI-like isoform 2 [Homo sapiens]                         31   5.6  
gi|223029418 SKI-like isoform 1 [Homo sapiens]                         31   5.6  
gi|116292174 fidgetin-like 2 [Homo sapiens]                            30   7.3  

>gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo
           sapiens]
          Length = 861

 Score = 1763 bits (4567), Expect = 0.0
 Identities = 861/861 (100%), Positives = 861/861 (100%)

Query: 1   MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV 60
           MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV
Sbjct: 1   MEALGPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRV 60

Query: 61  NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV 120
           NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV
Sbjct: 61  NREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKV 120

Query: 121 SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH 180
           SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH
Sbjct: 121 SVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYH 180

Query: 181 PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL 240
           PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL
Sbjct: 181 PLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPL 240

Query: 241 TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ 300
           TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ
Sbjct: 241 TDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQ 300

Query: 301 YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR 360
           YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR
Sbjct: 301 YFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATAR 360

Query: 361 SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA 420
           SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA
Sbjct: 361 SAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVA 420

Query: 421 TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ 480
           TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ
Sbjct: 421 TPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQ 480

Query: 481 PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ 540
           PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ
Sbjct: 481 PCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQ 540

Query: 541 VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK 600
           VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK
Sbjct: 541 VKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKK 600

Query: 601 PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 660
           PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR
Sbjct: 601 PSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 660

Query: 661 FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA 720
           FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA
Sbjct: 661 FKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCA 720

Query: 721 DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE 780
           DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE
Sbjct: 721 DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADE 780

Query: 781 LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD 840
           LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD
Sbjct: 781 LQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRD 840

Query: 841 PQALAKAVQIHHDTQHTMYFA 861
           PQALAKAVQIHHDTQHTMYFA
Sbjct: 841 PQALAKAVQIHHDTQHTMYFA 861


>gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo
           sapiens]
          Length = 857

 Score = 1475 bits (3818), Expect = 0.0
 Identities = 713/854 (83%), Positives = 778/854 (91%), Gaps = 12/854 (1%)

Query: 8   PPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDT 67
           P   +FQ PRRPG+GTVGKPI+LLAN+F+V IPKIDVYHY+VDIKP+K PRRVNREVV+ 
Sbjct: 16  PLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEY 75

Query: 68  MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSV 127
           MV+HFK QIFGDR+P YDGK+N+YT   LPIG +RVD EVT+PGEGKD+ FKVS++W+++
Sbjct: 76  MVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAI 135

Query: 128 VSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGRE 187
           VS ++L EAL      VP +SVQALDV  RHL SMRYTPVGRSFFSPPEGYYHPLGGGRE
Sbjct: 136 VSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGRE 195

Query: 188 VWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVK 247
           VWFGFHQSVRPAMW MMLNIDVSATAFY+AQP+IEFMCEVLDI+NI+EQ KPLTDSQRV+
Sbjct: 196 VWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVR 255

Query: 248 FTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYS 307
           FTKEI+GLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLE+GQ +ECTVAQYFKQKY+
Sbjct: 256 FTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYN 315

Query: 308 LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE 367
           LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE
Sbjct: 316 LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE 375

Query: 368 EISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVW 427
           EISRL+K+ S     DPY++EFGI V ++MTE+TGRVLPAP+LQYGGRN+ +ATPNQGVW
Sbjct: 376 EISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVW 433

Query: 428 DMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYA 487
           DMRGKQFY GIEIKVWA+ACFAPQKQCRE++LK+FTDQLRKISKDAGMPIQGQPCFCKYA
Sbjct: 434 DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYA 493

Query: 488 QGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT 547
           QGADSVEPMF+HLK TY GLQLI+VILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT
Sbjct: 494 QGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT 553

Query: 548 SPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVV 607
           SPQTLSNLCLKIN KLGGINN+LVPHQR +VFQQPVIFLGADVTHPPAGDGKKPSI AVV
Sbjct: 554 SPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVV 613

Query: 608 GSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRII 667
           GSMD HPSRYCATVRVQ  RQEI          I+DL+ MVRELLIQFYKSTRFKPTRII
Sbjct: 614 GSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVRELLIQFYKSTRFKPTRII 663

Query: 668 YYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVG 727
           +YR GV EGQ+ Q+   EL+AIR ACI LE+DY+PGITYIVVQKRHHTRLFCADK ER+G
Sbjct: 664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIG 723

Query: 728 KSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQ 787
           KSGN+PAGTTVD+ ITHP EFDFYLCSHAGIQGTSRPSHY VLWDDN FTADELQ+LTYQ
Sbjct: 724 KSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783

Query: 788 LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKA 847
           LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDK+HDS EGSH+SGQSNGRDPQALAKA
Sbjct: 784 LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKA 843

Query: 848 VQIHHDTQHTMYFA 861
           VQ+H DT  TMYFA
Sbjct: 844 VQVHQDTLRTMYFA 857


>gi|29294647 eukaryotic translation initiation factor 2C, 3 isoform
           a [Homo sapiens]
          Length = 860

 Score = 1436 bits (3716), Expect = 0.0
 Identities = 703/866 (81%), Positives = 770/866 (88%), Gaps = 21/866 (2%)

Query: 5   GPGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREV 64
           GP     L   PRRPG GT+GKPI+LLAN FQV+IPKIDVY Y+VDIKP+K PRRVNREV
Sbjct: 7   GPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREV 66

Query: 65  VDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEG-KDQTFKVSVQ 123
           VD+MV+HFK+ IFGDR+P YDGKR++YTA+PLP+    VD++VTLPGEG KD+ FKVS++
Sbjct: 67  VDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIK 126

Query: 124 WVSVVSLQLLLEALAGHLNEVP--------DDSVQALDVITRHLPSMRYTPVGRSFFSPP 175
           +VS VS  LL E L G     P         + V A+DV+ RHLPSM+YTPVGRSFFS P
Sbjct: 127 FVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAP 186

Query: 176 EGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINE 235
           EGY HPLGGGREVWFGFHQSVRPAMW MMLNIDVSATAFY+AQP+I+FMCEVLDI NI+E
Sbjct: 187 EGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDE 246

Query: 236 QTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAME 295
           Q +PLTDS RVKFTKEI+GLKVEVTHCG M+RKYRVCNVTRRPASHQTFPLQLENGQ +E
Sbjct: 247 QPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVE 306

Query: 296 CTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI 355
            TVAQYF++KY+LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI
Sbjct: 307 RTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI 366

Query: 356 KATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGR 415
           KATARSAPDRQEEISRLV+S +     DP+++EF   V +EM  +TGRVLPAPMLQYGGR
Sbjct: 367 KATARSAPDRQEEISRLVRSANYE--TDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGR 424

Query: 416 NKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGM 475
           N+TVATP+ GVWDMRGKQF+ G+EIK+WA+ACFA Q+QCRE++LK FTDQLRKISKDAGM
Sbjct: 425 NRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGM 484

Query: 476 PIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMA 535
           PIQGQPCFCKYAQGADSVEPMF+HLK TY GLQLI+VILPGKTPVYAEVKRVGDTLLGMA
Sbjct: 485 PIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMA 544

Query: 536 TQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPA 595
           TQCVQVKNV+KTSPQTLSNLCLKIN KLGGINN+LVPHQRPSVFQQPVIFLGADVTHPPA
Sbjct: 545 TQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPA 604

Query: 596 GDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQF 655
           GDGKKPSIAAVVGSMD HPSRYCATVRVQ  RQEI          IQDL +MVRELLIQF
Sbjct: 605 GDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEI----------IQDLASMVRELLIQF 654

Query: 656 YKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHT 715
           YKSTRFKPTRII+YR GVSEGQ +QV + EL+AIR+ACISLE+DY+PGITYIVVQKRHHT
Sbjct: 655 YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT 714

Query: 716 RLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNC 775
           RLFCAD+TERVG+SGN+PAGTTVD+ ITHP EFDFYLCSHAGIQGTSRPSHY VLWDDNC
Sbjct: 715 RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 774

Query: 776 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQ 835
           FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDK+HDSAEGSHVSGQ
Sbjct: 775 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ 834

Query: 836 SNGRDPQALAKAVQIHHDTQHTMYFA 861
           SNGRDPQALAKAVQIH DT  TMYFA
Sbjct: 835 SNGRDPQALAKAVQIHQDTLRTMYFA 860


>gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo
           sapiens]
          Length = 859

 Score = 1402 bits (3628), Expect = 0.0
 Identities = 674/860 (78%), Positives = 761/860 (88%), Gaps = 16/860 (1%)

Query: 6   PGPPASL----FQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVN 61
           P PP  +    F+PP RP  GT G+ I+L AN F++ IPKID+YHY++DIKPEK PRRVN
Sbjct: 12  PAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVN 71

Query: 62  REVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVS 121
           RE+V+ MV+HFK QIFGDR+P +DG++N+YTA PLPIGRD+V++EVTLPGEGKD+ FKVS
Sbjct: 72  REIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVS 131

Query: 122 VQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHP 181
           ++WVS VSLQ L +AL+G L  VP +++QALDV+ RHLPSMRYTPVGRSFF+  EG  +P
Sbjct: 132 IKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNP 191

Query: 182 LGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLT 241
           LGGGREVWFGFHQSVRP++W MMLNIDVSATAFY+AQP+IEF+CEVLD ++I EQ KPLT
Sbjct: 192 LGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLT 251

Query: 242 DSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQY 301
           DSQRVKFTKEI+GLKVE+THCGQMKRKYRVCNVTRRPASHQTFPLQ E+GQ +ECTVAQY
Sbjct: 252 DSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQY 311

Query: 302 FKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARS 361
           FK ++ L L+YPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMI+ATARS
Sbjct: 312 FKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARS 371

Query: 362 APDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVAT 421
           APDRQEEIS+L++S S     DPY++EFGI+V +EMT++TGRVL  P + YGGRNK +AT
Sbjct: 372 APDRQEEISKLMRSASF--NTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIAT 429

Query: 422 PNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQP 481
           P QGVWDMR KQF+ GIEIKVWA+ACFAPQ+QC E  LKSFT+QLRKIS+DAGMPIQGQP
Sbjct: 430 PVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP 489

Query: 482 CFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQV 541
           CFCKYAQGADSVEPMF+HLK TY GLQL+VVILPGKTPVYAEVKRVGDT+LGMATQCVQ+
Sbjct: 490 CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQM 549

Query: 542 KNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKP 601
           KNV +T+PQTLSNLCLKIN KLGG+NN+L+P  RP VFQQPVIFLGADVTHPPAGDGKKP
Sbjct: 550 KNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKP 609

Query: 602 SIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRF 661
           SIAAVVGSMD HP+RYCATVRVQ  RQEI          IQDL  MVRELLIQFYKSTRF
Sbjct: 610 SIAAVVGSMDAHPNRYCATVRVQQHRQEI----------IQDLAAMVRELLIQFYKSTRF 659

Query: 662 KPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCAD 721
           KPTRII+YR GVSEGQ +QV   EL+AIR+ACI LE+DY+PGIT+IVVQKRHHTRLFC D
Sbjct: 660 KPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTD 719

Query: 722 KTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADEL 781
           K ERVGKSGN+PAGTTVD+ ITHP+EFDFYLCSHAGIQGTSRPSHY VLWDDN F++DEL
Sbjct: 720 KNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDEL 779

Query: 782 QLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDP 841
           Q+LTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDK+HDSAEGSH SGQSNGRD 
Sbjct: 780 QILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDH 839

Query: 842 QALAKAVQIHHDTQHTMYFA 861
           QALAKAVQ+H DT  TMYFA
Sbjct: 840 QALAKAVQVHQDTLRTMYFA 859


>gi|29337286 eukaryotic translation initiation factor 2C, 3 isoform
           b [Homo sapiens]
          Length = 626

 Score = 1125 bits (2911), Expect = 0.0
 Identities = 547/638 (85%), Positives = 588/638 (92%), Gaps = 12/638 (1%)

Query: 224 MCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQT 283
           MCEVLDI NI+EQ +PLTDS RVKFTKEI+GLKVEVTHCG M+RKYRVCNVTRRPASHQT
Sbjct: 1   MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 60

Query: 284 FPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 343
           FPLQLENGQ +E TVAQYF++KY+LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI
Sbjct: 61  FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 120

Query: 344 KKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGR 403
           KKLTDNQTSTMIKATARSAPDRQEEISRLV+S +     DP+++EF   V +EM  +TGR
Sbjct: 121 KKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYE--TDPFVQEFQFKVRDEMAHVTGR 178

Query: 404 VLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFT 463
           VLPAPMLQYGGRN+TVATP+ GVWDMRGKQF+ G+EIK+WA+ACFA Q+QCRE++LK FT
Sbjct: 179 VLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFT 238

Query: 464 DQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAE 523
           DQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMF+HLK TY GLQLI+VILPGKTPVYAE
Sbjct: 239 DQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAE 298

Query: 524 VKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPV 583
           VKRVGDTLLGMATQCVQVKNV+KTSPQTLSNLCLKIN KLGGINN+LVPHQRPSVFQQPV
Sbjct: 299 VKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPV 358

Query: 584 IFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQD 643
           IFLGADVTHPPAGDGKKPSIAAVVGSMD HPSRYCATVRVQ  RQEI          IQD
Sbjct: 359 IFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEI----------IQD 408

Query: 644 LTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPG 703
           L +MVRELLIQFYKSTRFKPTRII+YR GVSEGQ +QV + EL+AIR+ACISLE+DY+PG
Sbjct: 409 LASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPG 468

Query: 704 ITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSR 763
           ITYIVVQKRHHTRLFCAD+TERVG+SGN+PAGTTVD+ ITHP EFDFYLCSHAGIQGTSR
Sbjct: 469 ITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSR 528

Query: 764 PSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKD 823
           PSHY VLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDK+
Sbjct: 529 PSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKE 588

Query: 824 HDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA 861
           HDSAEGSHVSGQSNGRDPQALAKAVQIH DT  TMYFA
Sbjct: 589 HDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA 626


>gi|66346725 piwi-like 1 [Homo sapiens]
          Length = 861

 Score =  159 bits (401), Expect = 1e-38
 Identities = 192/820 (23%), Positives = 335/820 (40%), Gaps = 113/820 (13%)

Query: 22  GTVGKPIRLLANHFQVQI-PKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDR 80
           G+ G  +RL  NHF++   P+  +Y Y +D  P    RR+   ++      F+ +    +
Sbjct: 106 GSSGIIVRLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALL------FQHEDLIGK 159

Query: 81  QPGYDGKRNMYTAHPLPIGRDRVDMEV-TLPGEGKDQTFKVSVQWVSVVSLQLLLEALAG 139
              +DG     T   LP    +   EV +    G+D    +++                 
Sbjct: 160 CHAFDG-----TILFLPKRLQQKVTEVFSKTRNGEDVRITITLT---------------- 198

Query: 140 HLNEVPDDSVQALD----VITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQS 195
             NE+P  S   L     +  R L  M    +GR++++P +    P      +W GF  S
Sbjct: 199 --NELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPNDPIDIP-SHRLVIWPGFTTS 255

Query: 196 VRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGL 255
           +     ++ML  DVS     R++ +++FM       N   QT+     ++V  +KE+ GL
Sbjct: 256 ILQYENSIMLCTDVSHKVL-RSETVLDFMF------NFYHQTEEHKFQEQV--SKELIGL 306

Query: 256 KVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHL 315
            V   +     + YRV ++        TF    +     E +  +Y++++Y+ ++     
Sbjct: 307 VVLTKY---NNKTYRVDDIDWDQNPKSTF----KKADGSEVSFLEYYRKQYNQEITDLKQ 359

Query: 316 PCLQVGQEQKH----------TYLPLEVCNIVAGQRCIKKLTD------NQTSTMIKATA 359
           P L V Q ++             L  E+C +         LTD      N    +   T 
Sbjct: 360 PVL-VSQPKRRRGPGGTLPGPAMLIPELCYLTG-------LTDKMRNDFNVMKDLAVHTR 411

Query: 360 RSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTV 419
            +   RQ E+ RL+            L+++G+   + +   +GR+L    +  GG+    
Sbjct: 412 LTPEQRQREVGRLIDYIHKNDNVQRELRDWGLSFDSNLLSFSGRILQTEKIHQGGKTFDY 471

Query: 420 ATPNQGVW--DMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPI 477
             P    W  + RG    +   +  W +       +    L+++    L K++   GM +
Sbjct: 472 -NPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQN----LFKVTPAMGMQM 526

Query: 478 QGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVIL--PGKTPVYAEVKRVGDTLLGMA 535
           +         +  D  E   + L+        IVV L    +   Y  +K+   T     
Sbjct: 527 RKAIMI----EVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKDKYDAIKKYLCTDCPTP 582

Query: 536 TQCVQVKNVVK--TSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHP 593
           +QCV  + + K  T     + + L++N K+GG         R  +  + V+ +G D  H 
Sbjct: 583 SQCVVARTLGKQQTVMAIATKIALQMNCKMGG------ELWRVDIPLKLVMIVGIDCYHD 636

Query: 594 PAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLI 653
                +  SIA  V S++   +R+ +    Q             QE++  L   ++  L 
Sbjct: 637 MTAGRR--SIAGFVASINEGMTRWFSRCIFQDR----------GQELVDGLKVCLQAALR 684

Query: 654 QFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRH 713
            +     + P+RII YR GV +GQ+K +   E+        S+   Y P +T IVV+KR 
Sbjct: 685 AWNSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVVKKRV 744

Query: 714 HTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDD 773
           +TR F     +  G+  N   GT +D  +T P  +DF++ S A   G+  P+HY V++D+
Sbjct: 745 NTRFFA----QSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDN 800

Query: 774 NCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAF 813
           +    D +Q LTY+LCH Y      + +PAP  YA  +AF
Sbjct: 801 SGLKPDHIQRLTYKLCHIYYNWPGVIRVPAPCQYAHKLAF 840


>gi|221316711 piwi-like 4 [Homo sapiens]
          Length = 852

 Score =  154 bits (390), Expect = 3e-37
 Identities = 185/810 (22%), Positives = 341/810 (42%), Gaps = 96/810 (11%)

Query: 22  GTVGKPIRLLANHFQVQIPKI-DVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDR 80
           G+ G P++L+ N F +  P+   +Y Y V   P+   RR+    +  +  H ++    ++
Sbjct: 100 GSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLR---IALLYSHSELS---NK 153

Query: 81  QPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGH 140
              +DG   ++ +  L               E K        Q    + + + L+     
Sbjct: 154 AKAFDGAI-LFLSQKL---------------EEKVTELSSETQRGETIKMTITLK----- 192

Query: 141 LNEVPDDS---VQALDVITRH-LPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSV 196
             E+P  S   +Q  ++I R  L  +    +GR+F++P E    P      +W GF  SV
Sbjct: 193 -RELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHK-LSLWPGFAISV 250

Query: 197 RPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLK 256
                 ++ + DVS     R + ++EFM  +     ++  T+           K++ GL 
Sbjct: 251 SYFERKLLFSADVSYKVL-RNETVLEFMTALCQRTGLSCFTQTCE--------KQLIGLI 301

Query: 257 VEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLP 316
           V   +     R Y + ++        TF    +     E T   Y+KQ+Y + +   + P
Sbjct: 302 VLTRY---NNRTYSIDDIDWSVKPTHTF----QKRDGTEITYVDYYKQQYDITVSDLNQP 354

Query: 317 CL-QVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTST--MIKATAR----SAPDRQEEI 369
            L  + +++++     ++ +++     +  LTD  TS   ++KA A     S   RQ+ +
Sbjct: 355 MLVSLLKKKRNDNSEAQLAHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRL 414

Query: 370 SRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDM 429
           +RLV +          L+ +G+   ++++ LTGR++P+  +          +      D+
Sbjct: 415 ARLVDNIQRNTNARFELETWGLHFGSQIS-LTGRIVPSEKILMQDHICQPVSAADWSKDI 473

Query: 430 RGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQG 489
           R  +      +  W + C        E + +SF + LR+++   G  +   P   K  + 
Sbjct: 474 RTCKILNAQSLNTWLILC----SDRTEYVAESFLNCLRRVAGSMGFNVD-YPKIIKVQEN 528

Query: 490 ADSVEPMFKHLKMTYVG--LQLIVVILPGKTPVYAE-VKRVGDTLLGMATQCVQVKNVVK 546
             +    F      YV   +QL++ ILP     Y + +K+   +   + +QCV  + + K
Sbjct: 529 PAA----FVRAIQQYVDPDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNK 584

Query: 547 TSPQT--LSNLCLKINAKLGG-INNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSI 603
                   + + +++  KLGG +  V +P        + ++ +G DV        K   +
Sbjct: 585 QGMMMSIATKIAMQMTCKLGGELWAVEIP-------LKSLMVVGIDVCKDALS--KDVMV 635

Query: 604 AAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKP 663
              V S++   +R+ +   +Q +  +++  L             +   L ++YK     P
Sbjct: 636 VGCVASVNPRITRWFSRCILQRTMTDVADCLKV----------FMTGALNKWYKYNHDLP 685

Query: 664 TRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKT 723
            RII YR GV +GQ+K +   E+  +  +      +    ++ IVV+K+   R F    T
Sbjct: 686 ARIIVYRAGVGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFF----T 741

Query: 724 ERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQL 783
           E      N P GT VDS  T    +DFYL S    +GT  P++Y V++DDN    D +Q 
Sbjct: 742 EMNRTVQNPPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQR 801

Query: 784 LTYQLCHTYVRCTRSVSIPAPAYYARLVAF 813
           LT++LCH Y      VS+PAP  YA  + F
Sbjct: 802 LTFKLCHLYYNWPGIVSVPAPCQYAHKLTF 831


>gi|209180418 piwi-like 2 [Homo sapiens]
          Length = 973

 Score =  143 bits (360), Expect = 8e-34
 Identities = 164/667 (24%), Positives = 287/667 (43%), Gaps = 73/667 (10%)

Query: 167 VGRSFFSPPEGYY---HPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEF 223
           VGR+F+ P        H L    ++W G+  S+R     + L  DVS         +I  
Sbjct: 339 VGRNFYDPTSAMVLQQHRL----QIWPGYAASIRRTDGGLFLLADVS-------HKVIRN 387

Query: 224 MCEVLDIQN-INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQ 282
            C VLD+ + I +Q K   +  + + TK + G  + +T      R YR+ +V        
Sbjct: 388 DC-VLDVMHAIYQQNK---EHFQDECTKLLVG-NIVITRYNN--RTYRIDDVDWNKTPKD 440

Query: 283 TFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCL---------QVGQEQKHTYLPLEV 333
           +F +        E T  +Y+ + Y + +K    P L           G   K   L L  
Sbjct: 441 SFTMS----DGKEITFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGEILLLPE 496

Query: 334 CNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVV 393
            + + G     K        + +    S       +  L++  +        L  +G+ +
Sbjct: 497 LSFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRL 556

Query: 394 HNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQ 453
             ++ ++ GRVLP   +    +N +  T  +  W     +  + + I +   A F P++ 
Sbjct: 557 QKDVHKIEGRVLPMERINL--KNTSFITSQELNWVKEVTRDPSILTIPMHFWALFYPKRA 614

Query: 454 CREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVG---LQLI 510
              D  +   + L KI+   GM +   P + +     D +E   + ++ T      +Q++
Sbjct: 615 M--DQARELVNMLEKIAGPIGMRMS-PPAWVELKD--DRIETYVRTIQSTLGAEGKIQMV 669

Query: 511 VVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSP--QTLSNLCLKINAKLGG-I 566
           V I+ G +  +Y  +K++      + +Q V V+ + + +        + L+IN KLGG +
Sbjct: 670 VCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGGEL 729

Query: 567 NNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTS 626
             V +P ++       ++ +G DV H P+   +  S+   V S++   +++ + V  Q  
Sbjct: 730 WGVDIPLKQ-------LMVIGMDVYHDPSRGMR--SVVGFVASINLTLTKWYSRVVFQMP 780

Query: 627 RQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPEL 686
            QEI          +  L   +   L +FY+     P +I+ YR GVS+GQ+K VA  E+
Sbjct: 781 HQEI----------VDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEI 830

Query: 687 IAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPS 746
             ++K C    E+Y+P +   VVQK+  T L+ A     V  +     GT VD TIT   
Sbjct: 831 PQLQK-CFEAFENYQPKMVVFVVQKKISTNLYLAAPQNFVTPT----PGTVVDHTITSCE 885

Query: 747 EFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAY 806
             DFYL +H   QG   P+HY  + +    + D +Q LT++LCH Y     ++ +PAP  
Sbjct: 886 WVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCK 945

Query: 807 YARLVAF 813
           YA  +AF
Sbjct: 946 YAHKLAF 952


>gi|24431985 piwi-like 2 [Homo sapiens]
          Length = 973

 Score =  143 bits (360), Expect = 8e-34
 Identities = 164/667 (24%), Positives = 287/667 (43%), Gaps = 73/667 (10%)

Query: 167 VGRSFFSPPEGYY---HPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEF 223
           VGR+F+ P        H L    ++W G+  S+R     + L  DVS         +I  
Sbjct: 339 VGRNFYDPTSAMVLQQHRL----QIWPGYAASIRRTDGGLFLLADVS-------HKVIRN 387

Query: 224 MCEVLDIQN-INEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQ 282
            C VLD+ + I +Q K   +  + + TK + G  + +T      R YR+ +V        
Sbjct: 388 DC-VLDVMHAIYQQNK---EHFQDECTKLLVG-NIVITRYNN--RTYRIDDVDWNKTPKD 440

Query: 283 TFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCL---------QVGQEQKHTYLPLEV 333
           +F +        E T  +Y+ + Y + +K    P L           G   K   L L  
Sbjct: 441 SFTMS----DGKEITFLEYYSKNYGITVKEEDQPLLIHRPSERQDNHGMLLKGEILLLPE 496

Query: 334 CNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVV 393
            + + G     K        + +    S       +  L++  +        L  +G+ +
Sbjct: 497 LSFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALECLLQRIAKNEAATNELMRWGLRL 556

Query: 394 HNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQ 453
             ++ ++ GRVLP   +    +N +  T  +  W     +  + + I +   A F P++ 
Sbjct: 557 QKDVHKIEGRVLPMERINL--KNTSFITSQELNWVKEVTRDPSILTIPMHFWALFYPKRA 614

Query: 454 CREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVG---LQLI 510
              D  +   + L KI+   GM +   P + +     D +E   + ++ T      +Q++
Sbjct: 615 M--DQARELVNMLEKIAGPIGMRMS-PPAWVELKD--DRIETYVRTIQSTLGAEGKIQMV 669

Query: 511 VVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSP--QTLSNLCLKINAKLGG-I 566
           V I+ G +  +Y  +K++      + +Q V V+ + + +        + L+IN KLGG +
Sbjct: 670 VCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGGEL 729

Query: 567 NNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTS 626
             V +P ++       ++ +G DV H P+   +  S+   V S++   +++ + V  Q  
Sbjct: 730 WGVDIPLKQ-------LMVIGMDVYHDPSRGMR--SVVGFVASINLTLTKWYSRVVFQMP 780

Query: 627 RQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPEL 686
            QEI          +  L   +   L +FY+     P +I+ YR GVS+GQ+K VA  E+
Sbjct: 781 HQEI----------VDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEI 830

Query: 687 IAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPS 746
             ++K C    E+Y+P +   VVQK+  T L+ A     V  +     GT VD TIT   
Sbjct: 831 PQLQK-CFEAFENYQPKMVVFVVQKKISTNLYLAAPQNFVTPT----PGTVVDHTITSCE 885

Query: 747 EFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAY 806
             DFYL +H   QG   P+HY  + +    + D +Q LT++LCH Y     ++ +PAP  
Sbjct: 886 WVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKLCHMYWNWPGTIRVPAPCK 945

Query: 807 YARLVAF 813
           YA  +AF
Sbjct: 946 YAHKLAF 952


>gi|153792298 piwi-like 3 [Homo sapiens]
          Length = 882

 Score =  135 bits (339), Expect = 2e-31
 Identities = 182/826 (22%), Positives = 345/826 (41%), Gaps = 117/826 (14%)

Query: 22  GTVGKPIRLLANHFQV-QIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDR 80
           G+ G  ++LLANHF+V   P+   Y Y+VD KP+     +   ++D   R F        
Sbjct: 119 GSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKF-------- 170

Query: 81  QPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTF-KVSVQWVSVVSLQLLLEALAG 139
                G+R+++  + L + R   +  V      KD+   K++V++             + 
Sbjct: 171 -----GERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEF-------------SK 212

Query: 140 HLNEVPDDSVQALDVITRH-LPSMRYTPVGRSFFSPPEG---YYHPLGGGREVWFGFHQS 195
            L     D ++  +++ R     + +  VGR++++  +    Y H  G   E+W G+  S
Sbjct: 213 ELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRH--GTSLEIWLGYVTS 270

Query: 196 VRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGL 255
           V     ++ L  DVS     R +   +F      I+  + Q +  T + R + T ++ G 
Sbjct: 271 VLQYENSITLCADVSHKLL-RIETAYDF------IKRTSAQAQ--TGNIREEVTNKLIGS 321

Query: 256 KVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHL 315
            V   +     + YRV ++  +     TF          + T   Y++Q++   +     
Sbjct: 322 IVLTKY---NNKTYRVDDIDWKQNPEDTF----NKSDGSKITYIDYYRQQHKEIVTVKKQ 374

Query: 316 PCLQ---------VGQEQKHTYLPLEVCNIVAGQRCIKKLTDN--QTSTMIKATA---RS 361
           P L           G +++   L  ++C++         LTD   +  +++K  A   R 
Sbjct: 375 PLLVSQGRWKKGLTGTQREPILLIPQLCHMTG-------LTDEICKDYSIVKELAKHTRL 427

Query: 362 APDRQ----EEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNK 417
           +P R+    +E    ++ N  V      L+ + +        + GRVL    +  G R  
Sbjct: 428 SPRRRHHTLKEFINTLQDNKKVR---ELLQLWDLKFDTNFLSVPGRVLKNANIVQGRR-- 482

Query: 418 TVATPNQGVW--DMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGM 475
            V   +QG W  ++R       + +  W +     +   RE +  S    L+ ++   G+
Sbjct: 483 MVKANSQGDWSREIRELPLLNAMPLHSWLI--LYSRSSHREAM--SLKGHLQSVTAPMGI 538

Query: 476 PIQGQPCFCKYAQGADSVEPMFKHLKMTY-VGLQLIVV-----ILPGKTPV-YAEVKRVG 528
            ++              ++ + K+ + T  +G+  ++V     ILP      Y  +KR  
Sbjct: 539 TMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYL 598

Query: 529 DTLLGMATQCVQVKNVVKTSPQTL-SNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLG 587
            T   + +QCV  K + K   +T+ + +  ++N K+GG         +     Q  +F+G
Sbjct: 599 CTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGAL------WKVETDVQRTMFVG 652

Query: 588 ADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNM 647
            D  H      ++ SIA  V S +   +++ +   +Q + +E+ +EL    +   D+   
Sbjct: 653 IDCFHDIVN--RQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDV--- 707

Query: 648 VRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYI 707
                  + K+    P  +I YR GV +GQ++ +   E   +     ++  +    + +I
Sbjct: 708 -------WCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFT-LAFI 759

Query: 708 VVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHY 767
           VV+KR +TR F     +      N P GT +D  +T    +DF++ S +   GT  P+HY
Sbjct: 760 VVKKRINTRFFL----KHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHY 815

Query: 768 QVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAF 813
            V++D    + D +Q LTY LCH Y      + +PAP +YA  +A+
Sbjct: 816 NVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAY 861


>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
          Length = 1088

 Score = 35.0 bits (79), Expect = 0.30
 Identities = 40/147 (27%), Positives = 54/147 (36%), Gaps = 30/147 (20%)

Query: 699 DYRPG------ITYIVVQKRHHTRLFCADKT---ERVGKSGNVPAGTTVDSTIT----HP 745
           DY PG      +  + V   H  R + A+ T   E V K G +      D+ +     H 
Sbjct: 746 DYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHI 805

Query: 746 SEFDFYLCSHAGIQGTSRPSHYQV-------------LWDD--NCFTADELQLLTYQLCH 790
              DF LC+  G + T    +YQ              LWDD  NC   D L+ L  +   
Sbjct: 806 KLTDFGLCT--GFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK 863

Query: 791 TYVRCTRSVSIPAPAYYARLVAFRARY 817
            + RC     +  P Y A  V  R  Y
Sbjct: 864 QHQRCLAHSLVGTPNYIAPEVLLRKGY 890


>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
          Length = 525

 Score = 31.2 bits (69), Expect = 4.3
 Identities = 39/170 (22%), Positives = 69/170 (40%), Gaps = 38/170 (22%)

Query: 187 EVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTD---- 242
           +V  G   ++ P  W++ L++  S+T F+   P  E    V++ ++    T  LTD    
Sbjct: 312 QVCHGVSTTIDP-FWDISLDLPGSSTPFWPLSPGSEG--NVVNGESHVSGTTTLTDCLRR 368

Query: 243 ---------SQRVKF---------TKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTF 284
                    S ++K          TK++   K+ +  C  +KR      + R+  ++ +F
Sbjct: 369 FTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSF 428

Query: 285 PLQLE-------------NGQAMECTVAQYFKQKYSLQLKYPHLPCLQVG 321
           PL+L+             NGQ  + T +     KYSL     H   L+ G
Sbjct: 429 PLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESG 478


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 31.2 bits (69), Expect = 4.3
 Identities = 41/171 (23%), Positives = 66/171 (38%), Gaps = 18/171 (10%)

Query: 6   PGPPASLFQPPRRPGLGTVG---------KPIRLLANHFQVQIPKIDVYHYD----VDIK 52
           P PP     P   PG G  G         + + ++ NH + Q    D +  D    VD K
Sbjct: 23  PQPPPPPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQ-GLFDQFRRDCLADVDTK 81

Query: 53  P--EKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLP 110
           P  +   +RV+  V + +  H         Q   + ++ +  +  L  G DR+  +V  P
Sbjct: 82  PAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDP 141

Query: 111 GEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPS 161
               + TF+  V+      L  L     G  N  PDD      +IT+ +P+
Sbjct: 142 KI--NHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPT 190


>gi|223029422 SKI-like isoform 3 [Homo sapiens]
          Length = 664

 Score = 30.8 bits (68), Expect = 5.6
 Identities = 14/37 (37%), Positives = 22/37 (59%)

Query: 624 QTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 660
           +  RQE+  EL   +E  Q L  M++EL +Q  KS++
Sbjct: 624 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 660


>gi|223029420 SKI-like isoform 2 [Homo sapiens]
          Length = 638

 Score = 30.8 bits (68), Expect = 5.6
 Identities = 14/37 (37%), Positives = 22/37 (59%)

Query: 624 QTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 660
           +  RQE+  EL   +E  Q L  M++EL +Q  KS++
Sbjct: 598 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 634


>gi|223029418 SKI-like isoform 1 [Homo sapiens]
          Length = 684

 Score = 30.8 bits (68), Expect = 5.6
 Identities = 14/37 (37%), Positives = 22/37 (59%)

Query: 624 QTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTR 660
           +  RQE+  EL   +E  Q L  M++EL +Q  KS++
Sbjct: 644 EADRQELQDELRQEREARQKLEMMIKELKLQILKSSK 680


>gi|116292174 fidgetin-like 2 [Homo sapiens]
          Length = 653

 Score = 30.4 bits (67), Expect = 7.3
 Identities = 13/20 (65%), Positives = 14/20 (70%)

Query: 3   ALGPGPPASLFQPPRRPGLG 22
           AL P PPA+L QPP  PG G
Sbjct: 178 ALPPPPPAALLQPPPPPGYG 197


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,931,940
Number of Sequences: 37866
Number of extensions: 1640942
Number of successful extensions: 3529
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3489
Number of HSP's gapped (non-prelim): 20
length of query: 861
length of database: 18,247,518
effective HSP length: 111
effective length of query: 750
effective length of database: 14,044,392
effective search space: 10533294000
effective search space used: 10533294000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.