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Search of human proteins with 28872863
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
sapiens]
(557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi... 1131 0.0
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom... 895 0.0
gi|189027129 phosphodiesterase 12 [Homo sapiens] 138 2e-32
gi|224282153 angel homolog 1 [Homo sapiens] 107 4e-23
gi|36030946 LOC90806 protein [Homo sapiens] 101 2e-21
gi|31083028 CCR4 carbon catabolite repression 4-like [Homo sapiens] 90 5e-18
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 76 7e-14
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 74 4e-13
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 74 4e-13
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 74 4e-13
gi|40254924 leucine rich repeat containing 59 [Homo sapiens] 72 1e-12
gi|197333706 leucine rich repeat containing 8 family, member D [... 71 3e-12
gi|34222199 leucine rich repeat containing 8 family, member D [H... 71 3e-12
gi|45827729 scribble isoform b [Homo sapiens] 71 3e-12
gi|45827731 scribble isoform a [Homo sapiens] 71 3e-12
gi|62241040 leucine rich repeat containing 8 family, member A [H... 70 7e-12
gi|187829877 leucine rich repeat containing 8 family, member A [... 70 7e-12
gi|187829871 leucine rich repeat containing 8 family, member A [... 70 7e-12
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 69 1e-11
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 69 1e-11
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 69 1e-11
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 67 3e-11
gi|53729363 leucine rich repeat and sterile alpha motif containi... 67 6e-11
gi|53729361 leucine rich repeat and sterile alpha motif containi... 67 6e-11
gi|53729359 leucine rich repeat and sterile alpha motif containi... 67 6e-11
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 65 1e-10
gi|61742786 leucine rich repeat and death domain containing prot... 65 1e-10
gi|61742784 leucine rich repeat and death domain containing prot... 65 1e-10
gi|61742782 leucine rich repeat and death domain containing prot... 65 1e-10
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 64 4e-10
>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
sapiens]
Length = 557
Score = 1131 bits (2925), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 60
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD
Sbjct: 1 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 60
Query: 61 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 120
NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF
Sbjct: 61 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 120
Query: 121 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 180
QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP
Sbjct: 121 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 180
Query: 181 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 240
DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE
Sbjct: 181 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 240
Query: 241 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV
Sbjct: 241 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
Query: 301 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 360
EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA
Sbjct: 301 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 360
Query: 361 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 420
HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG
Sbjct: 361 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 420
Query: 421 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 480
VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT
Sbjct: 421 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 480
Query: 481 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 540
NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL
Sbjct: 481 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 540
Query: 541 LLPFLPQVNGIHLPGRR 557
LLPFLPQVNGIHLPGRR
Sbjct: 541 LLPFLPQVNGIHLPGRR 557
>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
sapiens]
Length = 555
Score = 895 bits (2312), Expect = 0.0
Identities = 437/557 (78%), Positives = 493/557 (88%), Gaps = 7/557 (1%)
Query: 1 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 60
MPKEKY+PPDPRR+YTIMS+EE ANGKKSHWAELEISG+VRSLS SLWSLTHLTALHL+D
Sbjct: 6 MPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLND 65
Query: 61 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 120
N LSRIP DIAKLHNLVYLDLSSNK+RSLPAELGNMVSLREL LNNNLLRVLP+ELG+LF
Sbjct: 66 NYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLF 125
Query: 121 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 180
QLQTLGLKGNPL+QDILNLYQ+PDGTR+LLN++LDNL+ + EQ PPR WI L+E
Sbjct: 126 QLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA-----VHPEQLPPRPWITLKER 180
Query: 181 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 240
D+ P+A F+VMCYNVLCDKYATRQLYGYCPSWALNW+YRKK I++EI++C+ADI+SLQE
Sbjct: 181 DQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQE 240
Query: 241 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
VETEQY++ FL LKERGY+GFFSPKSRA+ MSEQERKHVDGCAIFFKTEKFTLVQKHTV
Sbjct: 241 VETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
Query: 301 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 360
EFNQ+AMANS+GSEAMLNRVMTKDNIGVAV+LE+ KE + KP +KQL++VANA
Sbjct: 301 EFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKE-LFGAGMKPIHAADKQLLIVANA 359
Query: 361 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 420
HMHWDPEYSDVKL+QTMMF+SEVKNI++KAS + S + +IPLVLCADLNSLPDSG
Sbjct: 360 HMHWDPEYSDVKLIQTMMFVSEVKNILEKAS-SRPGSPTADPNSIPLVLCADLNSLPDSG 418
Query: 421 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 480
VVEYLS GGV NHKDFKELRYNE L NFSC+GKNG++ GRITHGF+L+SAYE+ LMPYT
Sbjct: 419 VVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYT 478
Query: 481 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 540
NYTFDFKG+IDYIFYSK +N LG+LGPLD WLVENNI+GCPHP IPSDHFSL QLEL
Sbjct: 479 NYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLEL 538
Query: 541 LLPFLPQVNGIHLPGRR 557
P LP VNG+HLP RR
Sbjct: 539 HPPLLPLVNGVHLPNRR 555
>gi|189027129 phosphodiesterase 12 [Homo sapiens]
Length = 609
Score = 138 bits (347), Expect = 2e-32
Identities = 100/358 (27%), Positives = 168/358 (46%), Gaps = 48/358 (13%)
Query: 187 ALFSVMCYNVLCDKYATRQ-----LYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEV 241
AL + YN+L D YA + LY YC +AL DYR+ I +E+ NAD++ LQEV
Sbjct: 293 ALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVICLQEV 352
Query: 242 ETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVE 301
+ + + L+ G G F K +G A F++ KF+L+ +H +
Sbjct: 353 DRAVFSDSLVPALEAFGLEGVFRIKQH------------EGLATFYRKSKFSLLSQHDIS 400
Query: 302 FNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAH 361
F + A+ + + +L +++ + V L++ S+ S + I VAN H
Sbjct: 401 FYE-ALESDPLHKELLEKLVLYPSAQEKV---LQRSSVLQVSVLQSTKDSSKRICVANTH 456
Query: 362 MHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGV 421
++W P+ ++L+Q + L+ ++++ S +L + IP++ C D NS P +G+
Sbjct: 457 LYWHPKGGYIRLIQMAVALAHIRHV----SCDL-------YPGIPVIFCGDFNSTPSTGM 505
Query: 422 VEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTN 481
++ G + +H+D ++ +G+ N +TH FKL+SA G YTN
Sbjct: 506 YHFVINGSIPEDHED------------WASNGEEERCNMSLTHFFKLKSA--CGEPAYTN 551
Query: 482 YTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLE 539
Y F G +DYIF L ++ PL H V + P PSDH +L L+
Sbjct: 552 YVGGFHGCLDYIFIDLNALEVEQVI-PLPSHEEVTTH-QALPSVSHPSDHIALVCDLK 607
>gi|224282153 angel homolog 1 [Homo sapiens]
Length = 670
Score = 107 bits (266), Expect = 4e-23
Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 50/274 (18%)
Query: 185 PTALFSVMCYNVLCDKYATR--QLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVE 242
P F++M YN+L + +LY +C LNW+YR ++QE + DI+ LQEV+
Sbjct: 241 PQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQ 300
Query: 243 TEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEF 302
+ Y+ L+ G+ F+ ++ +T DGCA+ +K +F L+ VE+
Sbjct: 301 EDHYWEQLEPSLRMMGFTCFYKRRTGCKT---------DGCAVCYKPTRFRLLCASPVEY 351
Query: 303 NQLAMANSEGSEAMLNRVMTKDNIGVAVLLE-LRKESIEMPSGKPHLGTEKQLILVANAH 361
+ + ++ +DN+G+ +LL+ L E + S P + VAN H
Sbjct: 352 FRPGL-----------ELLNRDNVGLVLLLQPLVPEGLGQVSVAP--------LCVANTH 392
Query: 362 MHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGV 421
+ ++P DVKL Q + L+EV DK +R L + P++LC DLNS+PDS +
Sbjct: 393 ILYNPRRGDVKLAQMAILLAEV----DKVAR------LSDGSHCPIILCGDLNSVPDSPL 442
Query: 422 VEYLSTGGVE---------TNHKDFKELRYNESL 446
++ G ++ + +DF Y L
Sbjct: 443 YNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKL 476
>gi|36030946 LOC90806 protein [Homo sapiens]
Length = 544
Score = 101 bits (251), Expect = 2e-21
Identities = 69/242 (28%), Positives = 117/242 (48%), Gaps = 43/242 (17%)
Query: 189 FSVMCYNVLCDKYA--TRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQY 246
FSVM YN+L LY +C L+W +R I++EI +AD++ LQEV+ + Y
Sbjct: 167 FSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHY 226
Query: 247 YSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLA 306
+ L+ GY+ + ++ + DGCAI FK KF+L+ + VEF +
Sbjct: 227 GAEIRPSLESLGYHCEYKMRTGRKP---------DGCAICFKHSKFSLLSVNPVEFFRPD 277
Query: 307 MANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDP 366
++ ++ +DN+G+ +LL+ + P+ I VAN H+ ++P
Sbjct: 278 IS-----------LLDRDNVGLVLLLQPKIPYAACPA-----------ICVANTHLLYNP 315
Query: 367 EYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLS 426
D+KL Q M L+E+ ++ + G F P+V+C D NS+P S + ++
Sbjct: 316 RRGDIKLTQLAMLLAEISSVAHQKD--------GSF--CPIVMCGDFNSVPGSPLYSFIK 365
Query: 427 TG 428
G
Sbjct: 366 EG 367
>gi|31083028 CCR4 carbon catabolite repression 4-like [Homo sapiens]
Length = 431
Score = 90.1 bits (222), Expect = 5e-18
Identities = 87/349 (24%), Positives = 130/349 (37%), Gaps = 81/349 (23%)
Query: 191 VMCYNVLCDKYAT-RQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQYYSF 249
VM +N+L + + CP AL W+ RK I++EIL+ DI+ LQEV+ Y+
Sbjct: 145 VMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVD--HYFDT 202
Query: 250 FLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMAN 309
F L GY G F PK + + + DGCA+FF +F LV + + +
Sbjct: 203 FQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKT 262
Query: 310 SEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWDPEYS 369
++ + +A LE ++ + HL A W+ S
Sbjct: 263 NQ--------------VAIAQTLECKESGRQFCIAVTHL----------KARTGWERFRS 298
Query: 370 DVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYLSTGG 429
Q L ++NI A IPL++C D N+ P V ++ ++
Sbjct: 299 ----AQGCDLLQNLQNITQGAK-------------IPLIVCGDFNAEPTEEVYKHFASSS 341
Query: 430 VETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFDFKG- 488
+ N +KL SA PYT + G
Sbjct: 342 LNLNS------------------------------AYKLLSADGQSEPPYTTWKIRTSGE 371
Query: 489 ---IIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSL 534
+DYI+YSK LN L L + N + P PSDH SL
Sbjct: 372 CRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRL---PSFNYPSDHLSL 417
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 76.3 bits (186), Expect = 7e-14
Identities = 40/94 (42%), Positives = 59/94 (62%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
+++S+ A + +L L L+L N + IP ++ L +L YL L NKI+S+P +L + S
Sbjct: 154 QLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS 213
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L L+NNLL LP E+ L L+ L L+GNPL
Sbjct: 214 LRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/110 (40%), Positives = 63/110 (57%), Gaps = 4/110 (3%)
Query: 34 LEISGKV-RSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L +SG + + ASL L L L L N L IP++I L +L L L N I+ +P E
Sbjct: 125 LNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPE 184
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT---QDILNL 139
LGN+ SL L L +N ++ +P +L +L L++L L N LT ++ILNL
Sbjct: 185 LGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNL 234
Score = 55.8 bits (133), Expect = 1e-07
Identities = 30/80 (37%), Positives = 46/80 (57%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L+LS N +P+ + +L L L L N+++S+PAE+ N+ SL L+L N ++ +
Sbjct: 122 LQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEI 181
Query: 113 PFELGKLFQLQTLGLKGNPL 132
P ELG L L L L N +
Sbjct: 182 PPELGNLPSLNYLVLCDNKI 201
Score = 48.1 bits (113), Expect = 2e-05
Identities = 26/72 (36%), Positives = 40/72 (55%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
++ + L +L L L L DN + IP +++LH+L L L +N + LP E+ N++ L
Sbjct: 178 IKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHL 237
Query: 100 RELHLNNNLLRV 111
EL L N L V
Sbjct: 238 EELSLRGNPLVV 249
Score = 37.7 bits (86), Expect = 0.028
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 6/87 (6%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKI---RSLPAELGNMV---SLRELHLN 105
HL L +S N+L+ + ++ L L L +N++ +LP L SL+ L+L+
Sbjct: 69 HLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLS 128
Query: 106 NNLLRVLPFELGKLFQLQTLGLKGNPL 132
N + +P L +L LQTL L GN L
Sbjct: 129 GNCFQEVPASLLELRALQTLSLGGNQL 155
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/103 (42%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
SL + + LT L AL+LSDN +P DI KL L L L N + SLP E+G + L+E
Sbjct: 125 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 184
Query: 102 LHLNNNLLRVLPFELGKL---FQLQTLGLKGNPLTQDILNLYQ 141
LH+ N L VLP ELG L Q Q + NP I + +Q
Sbjct: 185 LHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 227
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/91 (38%), Positives = 56/91 (61%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L++L+H+T L LS N L+ +P +IA+L NL L+ +N+I LP ++ ++ L+ L+L
Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPLTQDIL 137
N L LP G L L+ L L N L+++ L
Sbjct: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSL 126
Score = 53.9 bits (128), Expect = 4e-07
Identities = 36/97 (37%), Positives = 53/97 (54%), Gaps = 2/97 (2%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSR--IPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
++ +L SL L L L+ N+LS +P + L L L LS N LP ++G +
Sbjct: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 156
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
L+ L L +N L LP E+G+L QL+ L ++GN LT
Sbjct: 157 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 193
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/103 (42%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
SL + + LT L AL+LSDN +P DI KL L L L N + SLP E+G + L+E
Sbjct: 72 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 131
Query: 102 LHLNNNLLRVLPFELGKL---FQLQTLGLKGNPLTQDILNLYQ 141
LH+ N L VLP ELG L Q Q + NP I + +Q
Sbjct: 132 LHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 174
Score = 53.9 bits (128), Expect = 4e-07
Identities = 36/97 (37%), Positives = 53/97 (54%), Gaps = 2/97 (2%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSR--IPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
++ +L SL L L L+ N+LS +P + L L L LS N LP ++G +
Sbjct: 44 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 103
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
L+ L L +N L LP E+G+L QL+ L ++GN LT
Sbjct: 104 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 140
Score = 48.9 bits (115), Expect = 1e-05
Identities = 26/72 (36%), Positives = 42/72 (58%)
Query: 66 IPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTL 125
+P +IA+L NL L+ +N+I LP ++ ++ L+ L+L N L LP G L L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 126 GLKGNPLTQDIL 137
L N L+++ L
Sbjct: 62 DLTYNNLSENSL 73
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 73.9 bits (180), Expect = 4e-13
Identities = 40/103 (38%), Positives = 63/103 (61%), Gaps = 1/103 (0%)
Query: 33 ELEI-SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++ + ++ +L S+ +L HL L L N LS +P +I L NL+ LD+S N++ LP
Sbjct: 178 ELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
E+ + SL +L ++ NLL +P +GKL +L L + N LTQ
Sbjct: 238 EISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ 280
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/100 (40%), Positives = 54/100 (54%), Gaps = 3/100 (3%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L S L +LT L ++D SL +P +I L+NL L+L N + LP L + L EL
Sbjct: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPLT---QDILNL 139
L NN + LP +G L L+ L L GN L+ Q+I NL
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
Score = 60.8 bits (146), Expect = 3e-09
Identities = 33/93 (35%), Positives = 56/93 (60%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
++SL ++ +L +L +L L +N L+ +P + +L L LDL +N+I +LP +G ++ L
Sbjct: 140 LQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHL 199
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
++L L+ N L LP E+G L L L + N L
Sbjct: 200 KDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/100 (38%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Query: 34 LEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L++S ++ L + LT LT L +S N L IP I KL L L + N++ LP
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+G SL EL L N L LP +GKL +L L N L
Sbjct: 285 VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKL 324
Score = 56.6 bits (135), Expect = 6e-08
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 8/120 (6%)
Query: 33 ELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++S ++ + S+ L S N L+R+P +L NL L ++ ++SLP
Sbjct: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLN 151
+GN+ +L L L NLL LP L +L +L+ L L N +Y P+ LL+
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNN-------EIYNLPESIGALLH 198
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 5/157 (3%)
Query: 7 EPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRI 66
E D R + EE +S L + ++R L + L L L LSDN + R+
Sbjct: 15 ESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRL 74
Query: 67 PSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLG 126
P +IA LV LD+S N+I +P + +L+ + N L LP +L L L
Sbjct: 75 PPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLS 134
Query: 127 LKG---NPLTQDILNLYQ--EPDGTRRLLNYLLDNLS 158
+ L ++I NLY + LL YL D+L+
Sbjct: 135 VNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT 171
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 8/136 (5%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ L ++ LT L L++N L +P I KL L L+ NK+ SLP E+G S
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGN-----PLTQDILN---LYQEPDGTRRLL 150
L + +N L +P E+ + +L L + GN PL+ L L+ + ++ LL
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLL 396
Query: 151 NYLLDNLSGTAKRITT 166
+ D T ++I T
Sbjct: 397 TFQTDTDYTTGEKILT 412
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/108 (30%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 26 GKKSHWAELEISG-KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSN 84
G H +L + G ++ L + +L +L L +S+N L R+P +I+ L +L L +S N
Sbjct: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253
Query: 85 KIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ ++P +G + L L ++ N L LP +G+ L L L N L
Sbjct: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQL 301
Score = 47.0 bits (110), Expect = 5e-05
Identities = 25/95 (26%), Positives = 49/95 (51%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
+ ++ + L L+ L + N L+++P + + +L L L+ N++ +LP +G + L
Sbjct: 255 LETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
L+ + N L LP E+G L ++ N LT+
Sbjct: 315 SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTR 349
>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
Length = 307
Score = 72.4 bits (176), Expect = 1e-12
Identities = 41/86 (47%), Positives = 53/86 (61%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L +L T L LS N L+ +PSD L +LV LDLS NK++ LPA+ G +V+L+ L L N
Sbjct: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPL 132
N L LP +L L+ L LK NPL
Sbjct: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
Score = 55.5 bits (132), Expect = 1e-07
Identities = 28/71 (39%), Positives = 43/71 (60%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ +L + LTHL L LS N L ++P+D +L NL +LDL +NK+ +LP + +
Sbjct: 50 KLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKN 109
Query: 99 LRELHLNNNLL 109
L+ L L +N L
Sbjct: 110 LKWLDLKDNPL 120
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/78 (38%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 56 LHLSDNSLSRIP-SDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPF 114
L LS + L+ +P ++A L LDLS NK+ +LP++ + L +L L+ N L+ LP
Sbjct: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
Query: 115 ELGKLFQLQTLGLKGNPL 132
+ G+L LQ L L N L
Sbjct: 80 DFGRLVNLQHLDLLNNKL 97
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 70.9 bits (172), Expect = 3e-12
Identities = 39/96 (40%), Positives = 59/96 (61%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ K+ SL +++SL L L +S N++S IP +I L NL +L ++ NK+ LP +L
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ LR L+L N + LP ++G+L QL L LKGN L
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
Score = 61.6 bits (148), Expect = 2e-09
Identities = 32/95 (33%), Positives = 56/95 (58%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ ++ S+ + +L +L+ S+N L +P + L L LD+S N I +P E+G + +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
L+ LH+ N + +LP +L K +L+TL L N +T
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/112 (35%), Positives = 61/112 (54%), Gaps = 5/112 (4%)
Query: 29 SHWAELEI-SGKVRSLSA--SLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNK 85
S+ EL++ S +R++ S L LT L L N + IP I + NL L S+NK
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 86 IRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDIL 137
+ SLP + ++ LR L ++ N + ++P E+G L LQ L + GN + DIL
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKV--DIL 767
Score = 40.0 bits (92), Expect = 0.006
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 25/113 (22%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIR------------------ 87
SL + ++ L L + L RIP I L NL LDL SN IR
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLK 689
Query: 88 -------SLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
++P + ++ +L L+ +NN L LP + L +L+ L + N ++
Sbjct: 690 LWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 70.9 bits (172), Expect = 3e-12
Identities = 39/96 (40%), Positives = 59/96 (61%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ K+ SL +++SL L L +S N++S IP +I L NL +L ++ NK+ LP +L
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ LR L+L N + LP ++G+L QL L LKGN L
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
Score = 61.6 bits (148), Expect = 2e-09
Identities = 32/95 (33%), Positives = 56/95 (58%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ ++ S+ + +L +L+ S+N L +P + L L LD+S N I +P E+G + +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
L+ LH+ N + +LP +L K +L+TL L N +T
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
Score = 55.8 bits (133), Expect = 1e-07
Identities = 40/112 (35%), Positives = 61/112 (54%), Gaps = 5/112 (4%)
Query: 29 SHWAELEI-SGKVRSLSA--SLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNK 85
S+ EL++ S +R++ S L LT L L N + IP I + NL L S+NK
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 86 IRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDIL 137
+ SLP + ++ LR L ++ N + ++P E+G L LQ L + GN + DIL
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKV--DIL 767
Score = 40.0 bits (92), Expect = 0.006
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 25/113 (22%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIR------------------ 87
SL + ++ L L + L RIP I L NL LDL SN IR
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLK 689
Query: 88 -------SLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
++P + ++ +L L+ +NN L LP + L +L+ L + N ++
Sbjct: 690 LWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 70.9 bits (172), Expect = 3e-12
Identities = 42/103 (40%), Positives = 62/103 (60%), Gaps = 1/103 (0%)
Query: 33 ELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
+L++ G + L +L +L +L L L N LS +P ++ L LV LD+S N++ LPA
Sbjct: 178 QLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
ELG +V L +L L+ NLLR LP +G+L QL L + N L +
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 63.5 bits (153), Expect = 5e-10
Identities = 40/87 (45%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L SL HL L+D SL +P D+ L NLV L+L N ++SLPA L +V L +L L
Sbjct: 127 LRSLAHLA---LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPLT 133
N L VLP LG L L+ L L N L+
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLS 210
Score = 60.1 bits (144), Expect = 5e-09
Identities = 38/106 (35%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Query: 29 SHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRS 88
+H A ++S +++L + +L +L L L +N L +P+ ++ L L LDL N +
Sbjct: 131 AHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 89 LPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
LP LG + +LREL L+ N L LP ELG L +L L + N L +
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Score = 59.3 bits (142), Expect = 9e-09
Identities = 35/101 (34%), Positives = 55/101 (54%), Gaps = 1/101 (0%)
Query: 33 ELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++S + + S+ L S N LSR+P +L +L +L L+ +++LP
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
++GN+ +L L L NLL+ LP L L +L+ L L GN L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Query: 34 LEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L++S ++ L A L L LT L LS N L R+P I +L L L + N++ +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+G+ +L EL L NLL LP LGKL +L L + N L
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Score = 57.0 bits (136), Expect = 4e-08
Identities = 38/132 (28%), Positives = 67/132 (50%), Gaps = 13/132 (9%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
+L+ L L++N L +P + KL L L++ N + +LP E+G V+L L L +N L V
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV 349
Query: 112 LPFELGKLFQLQTLGLKGNPLTQ--------DILNLYQEPDGTRRLLNYLLDNLSGTAKR 163
LP EL +L L + GN L ++ L+ + + +L + ++ + T ++
Sbjct: 350 LPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEK 409
Query: 164 ITT-----EQPP 170
+ T +QPP
Sbjct: 410 VLTCYLLPQQPP 421
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/93 (41%), Positives = 49/93 (52%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
++SL ASL L L L L N L +P + L NL L L N++ +LP ELGN+ L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L ++ N L LP ELG L L L L N L
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/93 (32%), Positives = 44/93 (47%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
+R L + L L+ L + N L + I NL L L+ N + +LP LG + L
Sbjct: 255 LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKL 314
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L+++ N L LP E+G L L L+ N L
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRL 347
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/116 (36%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
+L SL LT LT L++ N L +P +I L L L N++ LP EL + L
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 102 LHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPD---GTRRLLNYLL 154
L + N L+ LPF L L L+ L L N Q +L E D G + L YLL
Sbjct: 363 LDVAGNRLQSLPFALTHL-NLKALWLAENQ-AQPMLRFQTEDDARTGEKVLTCYLL 416
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/82 (34%), Positives = 42/82 (51%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L L N L +P +L NL L LS N+I+ LP E+ N + L EL ++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 113 PFELGKLFQLQTLGLKGNPLTQ 134
P + L+ GNPL++
Sbjct: 98 PESIKFCKALEIADFSGNPLSR 119
Score = 36.2 bits (82), Expect = 0.081
Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Query: 26 GKKSHWAELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSN 84
GK + L + + +L + L+ L L DN L+ +P ++A L LD++ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 85 KIRSLPAELGNMVSLRELHLNNN 107
+++SLP L ++ +L+ L L N
Sbjct: 369 RLQSLPFALTHL-NLKALWLAEN 390
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 70.9 bits (172), Expect = 3e-12
Identities = 42/103 (40%), Positives = 62/103 (60%), Gaps = 1/103 (0%)
Query: 33 ELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
+L++ G + L +L +L +L L L N LS +P ++ L LV LD+S N++ LPA
Sbjct: 178 QLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
ELG +V L +L L+ NLLR LP +G+L QL L + N L +
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 63.5 bits (153), Expect = 5e-10
Identities = 40/87 (45%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L SL HL L+D SL +P D+ L NLV L+L N ++SLPA L +V L +L L
Sbjct: 127 LRSLAHLA---LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGG 183
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPLT 133
N L VLP LG L L+ L L N L+
Sbjct: 184 NDLEVLPDTLGALPNLRELWLDRNQLS 210
Score = 60.1 bits (144), Expect = 5e-09
Identities = 38/106 (35%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Query: 29 SHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRS 88
+H A ++S +++L + +L +L L L +N L +P+ ++ L L LDL N +
Sbjct: 131 AHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 89 LPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
LP LG + +LREL L+ N L LP ELG L +L L + N L +
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Score = 59.3 bits (142), Expect = 9e-09
Identities = 35/101 (34%), Positives = 55/101 (54%), Gaps = 1/101 (0%)
Query: 33 ELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++S + + S+ L S N LSR+P +L +L +L L+ +++LP
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
++GN+ +L L L NLL+ LP L L +L+ L L GN L
Sbjct: 146 DVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Query: 34 LEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L++S ++ L A L L LT L LS N L R+P I +L L L + N++ +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+G+ +L EL L NLL LP LGKL +L L + N L
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Score = 57.0 bits (136), Expect = 4e-08
Identities = 38/132 (28%), Positives = 67/132 (50%), Gaps = 13/132 (9%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
+L+ L L++N L +P + KL L L++ N + +LP E+G V+L L L +N L V
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV 349
Query: 112 LPFELGKLFQLQTLGLKGNPLTQ--------DILNLYQEPDGTRRLLNYLLDNLSGTAKR 163
LP EL +L L + GN L ++ L+ + + +L + ++ + T ++
Sbjct: 350 LPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEK 409
Query: 164 ITT-----EQPP 170
+ T +QPP
Sbjct: 410 VLTCYLLPQQPP 421
Score = 56.2 bits (134), Expect = 8e-08
Identities = 39/93 (41%), Positives = 49/93 (52%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
++SL ASL L L L L N L +P + L NL L L N++ +LP ELGN+ L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L ++ N L LP ELG L L L L N L
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
Score = 50.8 bits (120), Expect = 3e-06
Identities = 30/93 (32%), Positives = 44/93 (47%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
+R L + L L+ L + N L + I NL L L+ N + +LP LG + L
Sbjct: 255 LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKL 314
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L+++ N L LP E+G L L L+ N L
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRL 347
Score = 50.4 bits (119), Expect = 4e-06
Identities = 42/116 (36%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
+L SL LT LT L++ N L +P +I L L L N++ LP EL + L
Sbjct: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
Query: 102 LHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPD---GTRRLLNYLL 154
L + N L+ LPF L L L+ L L N Q +L E D G + L YLL
Sbjct: 363 LDVAGNRLQSLPFALTHL-NLKALWLAENQ-AQPMLRFQTEDDARTGEKVLTCYLL 416
Score = 47.0 bits (110), Expect = 5e-05
Identities = 28/82 (34%), Positives = 42/82 (51%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L L N L +P +L NL L LS N+I+ LP E+ N + L EL ++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 113 PFELGKLFQLQTLGLKGNPLTQ 134
P + L+ GNPL++
Sbjct: 98 PESIKFCKALEIADFSGNPLSR 119
Score = 36.2 bits (82), Expect = 0.081
Identities = 24/83 (28%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Query: 26 GKKSHWAELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSN 84
GK + L + + +L + L+ L L DN L+ +P ++A L LD++ N
Sbjct: 309 GKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 85 KIRSLPAELGNMVSLRELHLNNN 107
+++SLP L ++ +L+ L L N
Sbjct: 369 RLQSLPFALTHL-NLKALWLAEN 390
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 69.7 bits (169), Expect = 7e-12
Identities = 38/94 (40%), Positives = 56/94 (59%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ + L+ L L LS N+L+ +P+DI L NL L +++N+I +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR LHL NN+L+ LP +G+L L + L+GN L
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/146 (34%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Query: 27 KKSHWAELE-ISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIA--KLHNLVYLDLSS 83
K ++ ELE I + + S++SL +L + L DN+L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 84 NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEP 143
N I +P ++GN+ +L L+LN N + +P +L +L+ L L N NL P
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN-------NLTFLP 701
Query: 144 DGTRRLLNYLLDNLSGTAKRITTEQP 169
L N L NL+ TA RI T P
Sbjct: 702 ADIGLLQN--LQNLAITANRIETLPP 725
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ ++ +L L+ L ALHL +N L +PS + +L NL ++L N++ LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 97 VSLRE--LHLNNNLLRVLPFEL 116
L+ L + +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 29.3 bits (64), Expect = 9.9
Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNL--VYLDLSSNKIRSLPAELGNMVSLRELH 103
+++ L L L L IP IA+L L ++L ++ KI + PA +LR LH
Sbjct: 441 TVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA-PALAFLRENLRALH 499
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRL 149
+ ++ +P + L L+ L L GN ++ N Y DG R L
Sbjct: 500 IKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN--NRYIVIDGLREL 543
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 69.7 bits (169), Expect = 7e-12
Identities = 38/94 (40%), Positives = 56/94 (59%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ + L+ L L LS N+L+ +P+DI L NL L +++N+I +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR LHL NN+L+ LP +G+L L + L+GN L
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/146 (34%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Query: 27 KKSHWAELE-ISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIA--KLHNLVYLDLSS 83
K ++ ELE I + + S++SL +L + L DN+L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 84 NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEP 143
N I +P ++GN+ +L L+LN N + +P +L +L+ L L N NL P
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN-------NLTFLP 701
Query: 144 DGTRRLLNYLLDNLSGTAKRITTEQP 169
L N L NL+ TA RI T P
Sbjct: 702 ADIGLLQN--LQNLAITANRIETLPP 725
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ ++ +L L+ L ALHL +N L +PS + +L NL ++L N++ LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 97 VSLRE--LHLNNNLLRVLPFEL 116
L+ L + +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 29.3 bits (64), Expect = 9.9
Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNL--VYLDLSSNKIRSLPAELGNMVSLRELH 103
+++ L L L L IP IA+L L ++L ++ KI + PA +LR LH
Sbjct: 441 TVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA-PALAFLRENLRALH 499
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRL 149
+ ++ +P + L L+ L L GN ++ N Y DG R L
Sbjct: 500 IKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN--NRYIVIDGLREL 543
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 69.7 bits (169), Expect = 7e-12
Identities = 38/94 (40%), Positives = 56/94 (59%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K+ + L+ L L LS N+L+ +P+DI L NL L +++N+I +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR LHL NN+L+ LP +G+L L + L+GN L
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/146 (34%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Query: 27 KKSHWAELE-ISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIA--KLHNLVYLDLSS 83
K ++ ELE I + + S++SL +L + L DN+L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 84 NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEP 143
N I +P ++GN+ +L L+LN N + +P +L +L+ L L N NL P
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN-------NLTFLP 701
Query: 144 DGTRRLLNYLLDNLSGTAKRITTEQP 169
L N L NL+ TA RI T P
Sbjct: 702 ADIGLLQN--LQNLAITANRIETLPP 725
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/82 (32%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ ++ +L L+ L ALHL +N L +PS + +L NL ++L N++ LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 97 VSLRE--LHLNNNLLRVLPFEL 116
L+ L + +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 29.3 bits (64), Expect = 9.9
Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 5/106 (4%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNL--VYLDLSSNKIRSLPAELGNMVSLRELH 103
+++ L L L L IP IA+L L ++L ++ KI + PA +LR LH
Sbjct: 441 TVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA-PALAFLRENLRALH 499
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRL 149
+ ++ +P + L L+ L L GN ++ N Y DG R L
Sbjct: 500 IKFTDIKEIPLWIYSLKTLEELHLTGNLSAEN--NRYIVIDGLREL 543
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 68.9 bits (167), Expect = 1e-11
Identities = 37/90 (41%), Positives = 57/90 (63%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
+S L++L L LS+N L+ +P+ + L +LV L+LSSN+++SLPAE+ M L+ L
Sbjct: 166 ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHL 225
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
N+NLL +P EL + L+ L L+ N L
Sbjct: 226 DCNSNLLETIPPELAGMESLELLYLRRNKL 255
Score = 63.2 bits (152), Expect = 6e-10
Identities = 37/97 (38%), Positives = 58/97 (59%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
+ K++SL+ L L LT L + DN L+ +PS I +L NL L++S NK++ LP E+ N+
Sbjct: 91 NNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNL 150
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
+L+ L+L +N L + +L L+ L L N LT
Sbjct: 151 RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLT 187
Score = 60.5 bits (145), Expect = 4e-09
Identities = 31/86 (36%), Positives = 53/86 (61%)
Query: 48 WSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNN 107
W T LT L +S+N L + D+ L L LD+ N++ SLP+ + + +L++L++++N
Sbjct: 79 WEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHN 138
Query: 108 LLRVLPFELGKLFQLQTLGLKGNPLT 133
L++LP E+ L L+ L L+ N LT
Sbjct: 139 KLKILPEEITNLRNLKCLYLQHNELT 164
Score = 60.1 bits (144), Expect = 5e-09
Identities = 38/106 (35%), Positives = 63/106 (59%), Gaps = 4/106 (3%)
Query: 49 SLTHLTALHLSDNSLSRIPSDIAK-LHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNN 107
S + L LH+ +N + + ++ K L++++ LDL NK++S+P E+ + SL L L+NN
Sbjct: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNN 322
Query: 108 LLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYL 153
+ LP+ LG L L+ L L+GNPL + + GT+ +L YL
Sbjct: 323 DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISK--GTQEVLKYL 365
Score = 59.7 bits (143), Expect = 7e-09
Identities = 33/86 (38%), Positives = 53/86 (61%), Gaps = 1/86 (1%)
Query: 29 SHWAELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIR 87
S+ +L++S + ++ AS SL+ L L+LS N L +P++I ++ L +LD +SN +
Sbjct: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
Query: 88 SLPAELGNMVSLRELHLNNNLLRVLP 113
++P EL M SL L+L N LR LP
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLP 259
Score = 56.6 bits (135), Expect = 6e-08
Identities = 32/94 (34%), Positives = 55/94 (58%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K++ L + +L +L L+L N L+ I +L NL LDLS+N + ++PA ++ S
Sbjct: 139 KLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSS 198
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L L+L++N L+ LP E+ ++ +L+ L N L
Sbjct: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLL 232
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/119 (31%), Positives = 61/119 (51%), Gaps = 3/119 (2%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSL-PAELGNMVS 98
+ SL + SL L ++LS N +P + ++ L + +S+N++ S+ P ++ M +
Sbjct: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNL 157
L L L NN L +P ELG L+TL L GNP + + GT +L YL D +
Sbjct: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMK--GTAAILEYLRDRI 600
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/73 (36%), Positives = 46/73 (63%)
Query: 58 LSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELG 117
LS N LS I ++ L L +LDL +N + SLP E+ ++V L+ ++L+ N ++LP L
Sbjct: 456 LSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLY 515
Query: 118 KLFQLQTLGLKGN 130
++F L+T+ + N
Sbjct: 516 RIFTLETILISNN 528
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/79 (37%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVY-LDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
+T+++ S N L IP + +L +V +DLS NK+ + EL + L L L NN L
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
Query: 112 LPFELGKLFQLQTLGLKGN 130
LP E+ L +LQT+ L N
Sbjct: 487 LPEEMESLVRLQTINLSFN 505
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRI-PSDIAKLHNLVYLDLSSNKIRSLPAELGNMV 97
+ + L L+ + L + +S+N + + P + + NL LDL +N + +P ELGN V
Sbjct: 506 RFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
Query: 98 SLRELHLNNNLLRV 111
+LR L L+ N RV
Sbjct: 566 NLRTLLLDGNPFRV 579
Score = 32.7 bits (73), Expect = 0.90
Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 1/55 (1%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAEL 93
K++S+ + L L L LS+N +S +P + LH L +L L N +R++ E+
Sbjct: 300 KLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREI 353
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 68.6 bits (166), Expect = 1e-11
Identities = 43/125 (34%), Positives = 71/125 (56%), Gaps = 5/125 (4%)
Query: 33 ELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL+ S +V +L +S+ LT+L N L ++P +I N+ L L SNK+ +LP
Sbjct: 303 ELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRR--- 148
E+G+M L+ ++L++N L+ LPF KL QL + L N ++ ++ L +E D +
Sbjct: 363 EMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ-SKPLIPLQKETDSETQKMV 421
Query: 149 LLNYL 153
L NY+
Sbjct: 422 LTNYM 426
Score = 57.4 bits (137), Expect = 3e-08
Identities = 30/96 (31%), Positives = 53/96 (55%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
S ++ L ++ SL ++T L + +N L +P I L ++ LD S N++ +LP+ +G +
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+LR ++N L+ LP E+G + L L N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 1/102 (0%)
Query: 34 LEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L++S + + + + +L L LS NSL ++P I L N+ L + N++ LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
+G ++S+ EL + N + LP +G+L L+T N L Q
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Score = 55.1 bits (131), Expect = 2e-07
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
+L AS+ +L +L L +S N + P +I L ++ S N I LP +++L +
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
Query: 102 LHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L+LN+ L LP G+L +LQ L L+ N L
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQL 173
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 33 ELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++S ++ ++ + LT + S N +S++P ++L NL L L+ + LPA
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
G + L+ L L N L++LP + +L QL+ L L N T+
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTE 198
Score = 52.8 bits (125), Expect = 8e-07
Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 3/109 (2%)
Query: 22 EAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDL 81
E +G K W + + ++ + + SL LT L +S N++ + I+ NL L L
Sbjct: 204 EQLSGLKEFWMD---ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260
Query: 82 SSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGN 130
SSN ++ LP +G++ ++ L ++ N L LP +G L ++ L N
Sbjct: 261 SSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN 309
Score = 49.7 bits (117), Expect = 7e-06
Identities = 30/88 (34%), Positives = 44/88 (50%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L A+ LT L L L +N L +P + +L L LDL SN+ +P L + L+E
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGN 130
++ N L +P +G L QL L + N
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L+L N + +P + +L L L N + +LPA + N+++LREL ++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 113 PFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLN 151
P + L + NP++ + PDG +LLN
Sbjct: 108 PENIKNCKVLTIVEASVNPIS-------KLPDGFSQLLN 139
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/86 (33%), Positives = 44/86 (51%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L L+ L + N L+ IP I L L YLD+S N I + + +L++L L++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPL 132
N L+ LP +G L + TL + N L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQL 288
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 68.6 bits (166), Expect = 1e-11
Identities = 43/125 (34%), Positives = 71/125 (56%), Gaps = 5/125 (4%)
Query: 33 ELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL+ S +V +L +S+ LT+L N L ++P +I N+ L L SNK+ +LP
Sbjct: 303 ELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRR--- 148
E+G+M L+ ++L++N L+ LPF KL QL + L N ++ ++ L +E D +
Sbjct: 363 EMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ-SKPLIPLQKETDSETQKMV 421
Query: 149 LLNYL 153
L NY+
Sbjct: 422 LTNYM 426
Score = 57.4 bits (137), Expect = 3e-08
Identities = 30/96 (31%), Positives = 53/96 (55%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
S ++ L ++ SL ++T L + +N L +P I L ++ LD S N++ +LP+ +G +
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+LR ++N L+ LP E+G + L L N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 1/102 (0%)
Query: 34 LEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAE 92
L++S + + + + +L L LS NSL ++P I L N+ L + N++ LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 93 LGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
+G ++S+ EL + N + LP +G+L L+T N L Q
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Score = 55.1 bits (131), Expect = 2e-07
Identities = 31/91 (34%), Positives = 49/91 (53%)
Query: 42 SLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRE 101
+L AS+ +L +L L +S N + P +I L ++ S N I LP +++L +
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
Query: 102 LHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
L+LN+ L LP G+L +LQ L L+ N L
Sbjct: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQL 173
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 33 ELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL++S ++ ++ + LT + S N +S++P ++L NL L L+ + LPA
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
G + L+ L L N L++LP + +L QL+ L L N T+
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTE 198
Score = 52.8 bits (125), Expect = 8e-07
Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 3/109 (2%)
Query: 22 EAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDL 81
E +G K W + + ++ + + SL LT L +S N++ + I+ NL L L
Sbjct: 204 EQLSGLKEFWMD---ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260
Query: 82 SSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGN 130
SSN ++ LP +G++ ++ L ++ N L LP +G L ++ L N
Sbjct: 261 SSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN 309
Score = 49.7 bits (117), Expect = 7e-06
Identities = 30/88 (34%), Positives = 44/88 (50%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L A+ LT L L L +N L +P + +L L LDL SN+ +P L + L+E
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGN 130
++ N L +P +G L QL L + N
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L+L N + +P + +L L L N + +LPA + N+++LREL ++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 113 PFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLN 151
P + L + NP++ + PDG +LLN
Sbjct: 108 PENIKNCKVLTIVEASVNPIS-------KLPDGFSQLLN 139
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/86 (33%), Positives = 44/86 (51%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L L+ L + N L+ IP I L L YLD+S N I + + +L++L L++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPL 132
N L+ LP +G L + TL + N L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQL 288
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 3/103 (2%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
+ L +S+ LT LT L+L N L +P+++ L NL+ L LS N + SLP L N+ L
Sbjct: 112 IHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKL 171
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT---QDILNL 139
R L L +N LR +P + +L L TL L+ N +T +DI NL
Sbjct: 172 RMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNL 214
Score = 66.2 bits (160), Expect = 7e-11
Identities = 39/95 (41%), Positives = 55/95 (57%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ SL + T + L+L+ N L++IP D++ L +L L LS+N ++ LP LGN+
Sbjct: 390 QLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
LREL L N L LP E+ L LQ L L N LT
Sbjct: 450 LRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLT 484
Score = 65.1 bits (157), Expect = 2e-10
Identities = 31/95 (32%), Positives = 58/95 (61%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ ++ + +L+ L+ L + +N + ++P++I +L NL+ LD++ N++ LP E+GN
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ 262
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
+ L L +N L LP +G L L LGL+ N L+
Sbjct: 263 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 297
Score = 63.2 bits (152), Expect = 6e-10
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 1/108 (0%)
Query: 25 NGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSN 84
N KK +L K+R + + ++ L LT L+L N ++ + DI L L L + N
Sbjct: 167 NLKKLRMLDLR-HNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIREN 225
Query: 85 KIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
KI+ LPAE+G + +L L + +N L LP E+G Q+ L L+ N L
Sbjct: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Score = 62.0 bits (149), Expect = 1e-09
Identities = 35/92 (38%), Positives = 54/92 (58%)
Query: 40 VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSL 99
++ L L +L L L L +N L +P++IA L +L L L++N++ +LP +G++ +L
Sbjct: 437 LKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNL 496
Query: 100 RELHLNNNLLRVLPFELGKLFQLQTLGLKGNP 131
L L NLL LP E+G L L+ L L NP
Sbjct: 497 THLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/110 (36%), Positives = 60/110 (54%), Gaps = 2/110 (1%)
Query: 25 NGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSN 84
N +K +LE K+ SL + L L L L++N L+ +P I L NL +L L N
Sbjct: 446 NLRKLRELDLE-ENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504
Query: 85 KIRSLPAELGNMVSLRELHLNNN-LLRVLPFELGKLFQLQTLGLKGNPLT 133
+ LP E+G + +L EL+LN+N L LPFEL +L + ++ PL+
Sbjct: 505 LLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Score = 61.2 bits (147), Expect = 2e-09
Identities = 31/80 (38%), Positives = 52/80 (65%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L+ L++ DN L+ +P D ++V L+L++N++ +P ++ +VSL L L+NNLL+ L
Sbjct: 381 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440
Query: 113 PFELGKLFQLQTLGLKGNPL 132
P LG L +L+ L L+ N L
Sbjct: 441 PHGLGNLRKLRELDLEENKL 460
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/84 (42%), Positives = 46/84 (54%)
Query: 50 LTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLL 109
L L L LS+N L ++P + L L LDL NK+ SLP E+ + L++L L NN L
Sbjct: 424 LVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQL 483
Query: 110 RVLPFELGKLFQLQTLGLKGNPLT 133
LP +G L L LGL N LT
Sbjct: 484 TTLPRGIGHLTNLTHLGLGENLLT 507
Score = 59.3 bits (142), Expect = 9e-09
Identities = 31/95 (32%), Positives = 49/95 (51%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
K++ L A + L +L L ++ N L +P +I + LDL N++ LP +GN+ S
Sbjct: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
L L L N L +P L K L+ L L+ N ++
Sbjct: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Score = 58.9 bits (141), Expect = 1e-08
Identities = 33/98 (33%), Positives = 55/98 (56%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
S K++SL A + L +L L LS+NSL+ +P + L L LDL NK+R +P+ + +
Sbjct: 132 SNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRL 191
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
SL L+L N + + ++ L +L L ++ N + Q
Sbjct: 192 DSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/79 (44%), Positives = 48/79 (60%)
Query: 56 LHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFE 115
L LS S+ +PS I +L L L L SNK++SLPAE+G +V+L L L+ N L LP
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 116 LGKLFQLQTLGLKGNPLTQ 134
L L +L+ L L+ N L +
Sbjct: 165 LDNLKKLRMLDLRHNKLRE 183
Score = 47.4 bits (111), Expect = 4e-05
Identities = 26/59 (44%), Positives = 34/59 (57%)
Query: 75 NLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLT 133
N + LDLS I LP+ + + L EL+L +N L+ LP E+G L L TL L N LT
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
Score = 47.4 bits (111), Expect = 4e-05
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ L + + T +T L L N L +P I L +L L L N++ ++P L +
Sbjct: 249 QLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSA 308
Query: 99 LRELHLNNNLLRVLPFE-LGKLFQLQTLGLKGN 130
L EL+L NN + LP L L +L +L L N
Sbjct: 309 LEELNLENNNISTLPESLLSSLVKLNSLTLARN 341
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 66.6 bits (161), Expect = 6e-11
Identities = 33/89 (37%), Positives = 54/89 (60%)
Query: 44 SASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELH 103
S SL SL + L L DN L+ +P D+ +L L L++ N++ LP +GN+ L+ L+
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ +N L+ LP +G+L L+TL + GN +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEI 162
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/94 (30%), Positives = 51/94 (54%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ +L L LT L L++ N L ++P I L L L++ NK++ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L+++ N ++ LP L + L+ L L + +
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
Score = 50.8 bits (120), Expect = 3e-06
Identities = 37/108 (34%), Positives = 53/108 (49%), Gaps = 14/108 (12%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
HLT+L SL L + LDL N++ +LP +LG + +L+ L++ N L
Sbjct: 66 HLTSLLPKSCSL-------LSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
Query: 112 LPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSG 159
LP +G L QLQTL +K N L + PD L + N+SG
Sbjct: 119 LPRSIGNLTQLQTLNVKDN-------KLKELPDTVGELRSLRTLNISG 159
Score = 46.6 bits (109), Expect = 6e-05
Identities = 40/137 (29%), Positives = 69/137 (50%), Gaps = 12/137 (8%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ L S+ +LT L L++ DN L +P + +L +L L++S N+I+ LP L ++ +
Sbjct: 115 QLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
Query: 99 LRELHLNNNLLRVLPFEL---GKLFQLQTL----GLKGNPLTQDILNLYQEPDGTRRLLN 151
L L L+ + + P E+ G LQ L GL+ P +Q +L + E DG +
Sbjct: 175 LEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPIL-EQDG----IE 229
Query: 152 YLLDNLSGTAKRITTEQ 168
D+ G R + E+
Sbjct: 230 NSRDSPDGPTDRFSREE 246
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 66.6 bits (161), Expect = 6e-11
Identities = 33/89 (37%), Positives = 54/89 (60%)
Query: 44 SASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELH 103
S SL SL + L L DN L+ +P D+ +L L L++ N++ LP +GN+ L+ L+
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ +N L+ LP +G+L L+TL + GN +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEI 162
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/94 (30%), Positives = 51/94 (54%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ +L L LT L L++ N L ++P I L L L++ NK++ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L+++ N ++ LP L + L+ L L + +
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
Score = 50.8 bits (120), Expect = 3e-06
Identities = 37/108 (34%), Positives = 53/108 (49%), Gaps = 14/108 (12%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
HLT+L SL L + LDL N++ +LP +LG + +L+ L++ N L
Sbjct: 66 HLTSLLPKSCSL-------LSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
Query: 112 LPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSG 159
LP +G L QLQTL +K N L + PD L + N+SG
Sbjct: 119 LPRSIGNLTQLQTLNVKDN-------KLKELPDTVGELRSLRTLNISG 159
Score = 46.6 bits (109), Expect = 6e-05
Identities = 40/137 (29%), Positives = 69/137 (50%), Gaps = 12/137 (8%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ L S+ +LT L L++ DN L +P + +L +L L++S N+I+ LP L ++ +
Sbjct: 115 QLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
Query: 99 LRELHLNNNLLRVLPFEL---GKLFQLQTL----GLKGNPLTQDILNLYQEPDGTRRLLN 151
L L L+ + + P E+ G LQ L GL+ P +Q +L + E DG +
Sbjct: 175 LEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPIL-EQDG----IE 229
Query: 152 YLLDNLSGTAKRITTEQ 168
D+ G R + E+
Sbjct: 230 NSRDSPDGPTDRFSREE 246
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 66.6 bits (161), Expect = 6e-11
Identities = 33/89 (37%), Positives = 54/89 (60%)
Query: 44 SASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELH 103
S SL SL + L L DN L+ +P D+ +L L L++ N++ LP +GN+ L+ L+
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 104 LNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ +N L+ LP +G+L L+TL + GN +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEI 162
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/94 (30%), Positives = 51/94 (54%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ +L L LT L L++ N L ++P I L L L++ NK++ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L+++ N ++ LP L + L+ L L + +
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM 185
Score = 50.8 bits (120), Expect = 3e-06
Identities = 37/108 (34%), Positives = 53/108 (49%), Gaps = 14/108 (12%)
Query: 52 HLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRV 111
HLT+L SL L + LDL N++ +LP +LG + +L+ L++ N L
Sbjct: 66 HLTSLLPKSCSL-------LSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQ 118
Query: 112 LPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSG 159
LP +G L QLQTL +K N L + PD L + N+SG
Sbjct: 119 LPRSIGNLTQLQTLNVKDN-------KLKELPDTVGELRSLRTLNISG 159
Score = 46.6 bits (109), Expect = 6e-05
Identities = 40/137 (29%), Positives = 69/137 (50%), Gaps = 12/137 (8%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ L S+ +LT L L++ DN L +P + +L +L L++S N+I+ LP L ++ +
Sbjct: 115 QLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRT 174
Query: 99 LRELHLNNNLLRVLPFEL---GKLFQLQTL----GLKGNPLTQDILNLYQEPDGTRRLLN 151
L L L+ + + P E+ G LQ L GL+ P +Q +L + E DG +
Sbjct: 175 LEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPIL-EQDG----IE 229
Query: 152 YLLDNLSGTAKRITTEQ 168
D+ G R + E+
Sbjct: 230 NSRDSPDGPTDRFSREE 246
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/89 (38%), Positives = 53/89 (59%)
Query: 46 SLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLN 105
+L+ + L L+LS N L P + ++ L L+LS N LP+++GN+++L+ L L+
Sbjct: 294 TLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD 353
Query: 106 NNLLRVLPFELGKLFQLQTLGLKGNPLTQ 134
N L LP ELG L QL +LG+ N +Q
Sbjct: 354 GNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
Score = 52.4 bits (124), Expect = 1e-06
Identities = 31/87 (35%), Positives = 51/87 (58%), Gaps = 2/87 (2%)
Query: 52 HLTALHLSDNSLSRIP-SDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLR 110
HL LHL++N L P S + KL L L+LS NK++++P + N L L ++N +
Sbjct: 645 HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS 704
Query: 111 VLPFELGKLFQLQTLGLKGNPLTQDIL 137
+ P E+ +L Q+Q + L N LT+ ++
Sbjct: 705 IFP-EILQLPQIQFVDLSCNDLTEILI 730
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/93 (37%), Positives = 49/93 (52%), Gaps = 2/93 (2%)
Query: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
L ++ LT L+LS N +PS I L NL L L N + +LP ELGN+ L L ++
Sbjct: 318 LCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISF 377
Query: 107 NLLRVLPFELGKLFQLQTLGLKGNPLTQDILNL 139
N +P KL L + + GN L ++LNL
Sbjct: 378 NNFSQIPEVYEKLTMLDRVVMAGNCL--EVLNL 408
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/109 (33%), Positives = 50/109 (45%), Gaps = 29/109 (26%)
Query: 53 LTALHLSDNSLSRIPSDI-AKLHNLVYLDLSSNKIRSLPAE------------------- 92
L L L N+L+R+P + +K NL YL+ S+N + SLP+
Sbjct: 572 LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNL 631
Query: 93 --------LGNMVSLRELHLNNNLLRVLP-FELGKLFQLQTLGLKGNPL 132
L + LR LHL NN L+ P +L KL QL+ L L GN L
Sbjct: 632 LTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680
Score = 43.5 bits (101), Expect = 5e-04
Identities = 40/127 (31%), Positives = 64/127 (50%), Gaps = 11/127 (8%)
Query: 18 MSSEEAANGKKSHWAELEISG-KVRSLSASLWSLTH---------LTALHLSDNSLSRIP 67
+ S E + ++ EL +SG +R+L AS LT LT L LS N L +P
Sbjct: 459 LCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVP 518
Query: 68 SDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGL 127
+ + LD+S N + +P + + +SLR+L L +N ++ LP L + L+ L L
Sbjct: 519 DWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP-TLVEHIPLEVLDL 577
Query: 128 KGNPLTQ 134
+ N LT+
Sbjct: 578 QHNALTR 584
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 65.5 bits (158), Expect = 1e-10
Identities = 38/94 (40%), Positives = 61/94 (64%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++++L +L +L+ L L LS N L +P +I L +L+ L+L+SN+++SLPA L + S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L L++NLL +P +L +L L L L+ N L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 63.5 bits (153), Expect = 5e-10
Identities = 39/105 (37%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Query: 29 SHWAELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIR 87
+H A L++S + +L A + + L AL LS N LS +P + L L +L ++ N+++
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 88 SLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+LP LG + +L+ L L+ NLL LP E+G L L L L N L
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Score = 58.2 bits (139), Expect = 2e-08
Identities = 38/97 (39%), Positives = 52/97 (53%)
Query: 36 ISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGN 95
+ G + +L A L L HL L LS NSL +P+ + ++ L L LS N + LP LG
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 96 MVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ +L L + +N L+ LP LG L LQ L L N L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Score = 57.0 bits (136), Expect = 4e-08
Identities = 40/105 (38%), Positives = 56/105 (53%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L +L +L LT L ++ N L +P + L L LDLS N + +LP E+G + SL EL
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTR 147
+L +N L+ LP L L L+ L L N L +L + P TR
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAEL 93
S +++SL ASL L L L L N L+ +P+D+A+L L LDL N++R LP EL
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 65.5 bits (158), Expect = 1e-10
Identities = 38/94 (40%), Positives = 61/94 (64%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++++L +L +L+ L L LS N L +P +I L +L+ L+L+SN+++SLPA L + S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L L++NLL +P +L +L L L L+ N L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 63.5 bits (153), Expect = 5e-10
Identities = 39/105 (37%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Query: 29 SHWAELEIS-GKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIR 87
+H A L++S + +L A + + L AL LS N LS +P + L L +L ++ N+++
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 88 SLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+LP LG + +L+ L L+ NLL LP E+G L L L L N L
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL 229
Score = 58.2 bits (139), Expect = 2e-08
Identities = 38/97 (39%), Positives = 52/97 (53%)
Query: 36 ISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGN 95
+ G + +L A L L HL L LS NSL +P+ + ++ L L LS N + LP LG
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 96 MVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ +L L + +N L+ LP LG L LQ L L N L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Score = 57.0 bits (136), Expect = 4e-08
Identities = 40/105 (38%), Positives = 56/105 (53%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L +L +L LT L ++ N L +P + L L LDLS N + +LP E+G + SL EL
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTR 147
+L +N L+ LP L L L+ L L N L +L + P TR
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAEL 93
S +++SL ASL L L L L N L+ +P+D+A+L L LDL N++R LP EL
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 65.5 bits (158), Expect = 1e-10
Identities = 38/94 (40%), Positives = 61/94 (64%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++++L +L +L+ L L LS N L +P +I L +L+ L+L+SN+++SLPA L + S
Sbjct: 36 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 95
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
LR L L++NLL +P +L +L L L L+ N L
Sbjct: 96 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
Score = 57.0 bits (136), Expect = 4e-08
Identities = 33/80 (41%), Positives = 47/80 (58%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L AL LS N LS +P + L L +L ++ N++++LP LG + +L+ L L+ NLL L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 113 PFELGKLFQLQTLGLKGNPL 132
P E+G L L L L N L
Sbjct: 64 PPEIGGLGSLLELNLASNRL 83
Score = 57.0 bits (136), Expect = 4e-08
Identities = 40/105 (38%), Positives = 56/105 (53%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L +L +L LT L ++ N L +P + L L LDLS N + +LP E+G + SL EL
Sbjct: 17 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 76
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTR 147
+L +N L+ LP L L L+ L L N L +L + P TR
Sbjct: 77 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 121
Score = 47.8 bits (112), Expect = 3e-05
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAEL 93
S +++SL ASL L L L L N L+ +P+D+A+L L LDL N++R LP EL
Sbjct: 80 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
Score = 35.0 bits (79), Expect = 0.18
Identities = 24/60 (40%), Positives = 31/60 (51%)
Query: 73 LHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+ L L LS N + LP LG + +L L + +N L+ LP LG L LQ L L N L
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 63.9 bits (154), Expect = 4e-10
Identities = 41/117 (35%), Positives = 63/117 (53%), Gaps = 2/117 (1%)
Query: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
++ SL +++ L L L + +N L +P +I N+ + L SNK+ LP E+G M
Sbjct: 310 ELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQK 369
Query: 99 LRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDI-LNLYQEPDGTRRLL-NYL 153
LR L+L++N L+ LPF KL +L L L N I L P+ +R+L NY+
Sbjct: 370 LRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYM 426
Score = 60.5 bits (145), Expect = 4e-09
Identities = 34/96 (35%), Positives = 52/96 (54%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNM 96
S ++ L S+ L LT L + DN L+ +P+ I L L D S N++ SLP+ +G +
Sbjct: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
Query: 97 VSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
SLR L ++ N L LP E+G + + L+ N L
Sbjct: 322 HSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKL 357
Score = 60.1 bits (144), Expect = 5e-09
Identities = 31/84 (36%), Positives = 52/84 (61%)
Query: 50 LTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLL 109
+ +L L + +N+L +P I KL LVYLD+S N+I ++ ++ +L +L L++N+L
Sbjct: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
Query: 110 RVLPFELGKLFQLQTLGLKGNPLT 133
+ LP +G L +L TL + N LT
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLT 289
Score = 59.7 bits (143), Expect = 7e-09
Identities = 35/88 (39%), Positives = 48/88 (54%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L A+ L L L L +N L +P + KL L LDL +N+ LP L + +LREL
Sbjct: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGN 130
++NN L+VLP +GKL L L + N
Sbjct: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKN 240
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 33 ELEISGK-VRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPA 91
EL+IS V+ ++ LT + S N +S++P +L NL L L+ + LPA
Sbjct: 96 ELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPA 155
Query: 92 ELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGN 130
G +V LR L L N L+ LP + KL QL+ L L N
Sbjct: 156 NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
Score = 51.2 bits (121), Expect = 2e-06
Identities = 33/119 (27%), Positives = 55/119 (46%), Gaps = 23/119 (19%)
Query: 37 SGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELG-- 94
+ ++ L L++ L L + DN LS +P+ IA L NL LD+S N ++ P +
Sbjct: 55 ANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCC 114
Query: 95 ---------------------NMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+++L +L+LN+ L LP G+L +L+ L L+ N L
Sbjct: 115 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL 173
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/90 (32%), Positives = 44/90 (48%)
Query: 43 LSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLREL 102
L S+ L L L +S N + + DI+ L L LSSN ++ LP +G + L L
Sbjct: 222 LPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTL 281
Query: 103 HLNNNLLRVLPFELGKLFQLQTLGLKGNPL 132
+++N L +LP +G L L+ N L
Sbjct: 282 KVDDNQLTMLPNTIGNLSLLEEFDCSCNEL 311
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/99 (25%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 53 LTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVL 112
L L+L N + +P + L L + N + +LP + ++V+L+EL ++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
Query: 113 PFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLN 151
P + L + NP++ + PDG +LLN
Sbjct: 108 PENIKCCKCLTIIEASVNPIS-------KLPDGFTQLLN 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,736,629
Number of Sequences: 37866
Number of extensions: 955724
Number of successful extensions: 2983
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 2072
Number of HSP's gapped (non-prelim): 777
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.