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Search of human proteins with 28605137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
(151 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 307 3e-84
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 303 5e-83
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 86 1e-17
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 86 2e-17
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 85 3e-17
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 85 3e-17
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 85 3e-17
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 85 3e-17
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 84 5e-17
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 84 5e-17
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 84 5e-17
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 82 1e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 82 2e-16
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 82 2e-16
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 80 5e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 80 5e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 80 5e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 80 5e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 80 5e-16
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 80 7e-16
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 79 1e-15
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 79 1e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 78 3e-15
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 77 4e-15
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 77 4e-15
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 77 6e-15
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 77 6e-15
gi|62420875 integrin-linked kinase [Homo sapiens] 77 7e-15
gi|62420873 integrin-linked kinase [Homo sapiens] 77 7e-15
gi|4758606 integrin-linked kinase [Homo sapiens] 77 7e-15
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 307 bits (786), Expect = 3e-84
Identities = 151/151 (100%), Positives = 151/151 (100%)
Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
Sbjct: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
Sbjct: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
IAVMLLEGGANPDAKDHYEATAMHRAAAKDT
Sbjct: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 303 bits (775), Expect = 5e-83
Identities = 149/149 (100%), Positives = 149/149 (100%)
Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
Sbjct: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
Sbjct: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149
IAVMLLEGGANPDAKDHYEATAMHRAAAK
Sbjct: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 85.9 bits (211), Expect = 1e-17
Identities = 49/131 (37%), Positives = 71/131 (54%)
Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
+G +E +K + +K + T T LH+A G ++VE+LLQ G V +DD G
Sbjct: 34 NGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93
Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
PLH A S G E+V LL GA NA + TPLH AA K + ++ ++LL+ GA P +
Sbjct: 94 PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153
Query: 136 DHYEATAMHRA 146
+ TA+ A
Sbjct: 154 NTDGRTALDLA 164
Score = 79.0 bits (193), Expect = 1e-15
Identities = 48/138 (34%), Positives = 69/138 (50%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G +E +K+ + T LH+A +VE+LLQ G V+ KD G
Sbjct: 500 AKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
PLH A S G E+ + L+ GA VN + TPLH AA+K ++EI +LL+ GA+P
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
Query: 134 AKDHYEATAMHRAAAKDT 151
K+ T + DT
Sbjct: 620 KKNRDGNTPLDLVKDGDT 637
Score = 78.6 bits (192), Expect = 2e-15
Identities = 49/137 (35%), Positives = 67/137 (48%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G L +K+ D T T LH A + E+ E+LLQ G VN +D G
Sbjct: 653 AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGG 712
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
PLH AAS G ++ L+ A VNA ++ TPLH AA K R ++ +LL GA+P
Sbjct: 713 LIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772
Query: 134 AKDHYEATAMHRAAAKD 150
K+ T + +A D
Sbjct: 773 LKNQEGQTPLDLVSADD 789
Score = 74.3 bits (181), Expect = 4e-14
Identities = 47/121 (38%), Positives = 65/121 (53%), Gaps = 3/121 (2%)
Query: 31 SLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEI 88
S A + + L AC G E V+ L+ VN +D AG +PLH AA GR ++
Sbjct: 15 SAAAEAVEPAARELFEACRNGDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDV 73
Query: 89 VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
V+ LL GA V A + G PLH A S E+ +LL GA+P+A+D++ T +H AA
Sbjct: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133
Query: 149 K 149
K
Sbjct: 134 K 134
Score = 74.3 bits (181), Expect = 4e-14
Identities = 49/133 (36%), Positives = 68/133 (51%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG E++ + +D T LH A +IV+ LLQ G V+ KD
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
PLH A S G E+ + L+ GA VNA++ TPLH AASKNR E+ +LL GA+P
Sbjct: 245 LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304
Query: 134 AKDHYEATAMHRA 146
+ + +A+ A
Sbjct: 305 LLNCHNKSAIDLA 317
Score = 63.9 bits (154), Expect = 5e-11
Identities = 43/126 (34%), Positives = 69/126 (54%), Gaps = 2/126 (1%)
Query: 27 LADKSL-ATRTDQDSRTALHWACSAGHTE-IVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
LAD S A T + + L + +G+ E ++ L L V + D +PLH+AA
Sbjct: 163 LADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYN 222
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
R +IV+ LL GA V+A ++ PLH A S +E+ +L++ GA +A D ++ T +H
Sbjct: 223 RVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLH 282
Query: 145 RAAAKD 150
AA+K+
Sbjct: 283 EAASKN 288
Score = 55.5 bits (132), Expect = 2e-08
Identities = 32/99 (32%), Positives = 55/99 (55%), Gaps = 3/99 (3%)
Query: 38 QDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
Q TALH A ++ + +I E LL+ G +N+K +PLH+A+ +++V+ ++
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
A+VNA++ G T LH AA + +LL G +P+
Sbjct: 422 HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 460
Score = 54.7 bits (130), Expect = 3e-08
Identities = 33/112 (29%), Positives = 50/112 (44%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ E +L + D+ LH A S GH ++ L++ VN D ++PLH A
Sbjct: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEA 752
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
A GR ++ LL GA NQ G TPL ++ + + + A P
Sbjct: 753 AQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALP 804
Score = 50.1 bits (118), Expect = 7e-07
Identities = 44/151 (29%), Positives = 65/151 (43%), Gaps = 25/151 (16%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ E ++ ++ D T LH A + G EI + LLQ G K+ G +PL +
Sbjct: 573 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 632
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGC-----------------------TPLHYAASKN 117
G +I L G A ++A + GC TPLH AA N
Sbjct: 633 KD-GDTDIQDLLRGDAALLDAA-KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690
Query: 118 RHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
E+A LL+ GA+ +A+D +H AA+
Sbjct: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAAS 721
Score = 47.0 bits (110), Expect = 6e-06
Identities = 26/74 (35%), Positives = 44/74 (59%), Gaps = 3/74 (4%)
Query: 77 LHIAASAG---RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
LH AA++ R +I + LL KGA +N + TPLH A+ K +++ ++++ A +
Sbjct: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN 427
Query: 134 AKDHYEATAMHRAA 147
A D+ T++HRAA
Sbjct: 428 ALDNLGQTSLHRAA 441
Score = 45.8 bits (107), Expect = 1e-05
Identities = 44/189 (23%), Positives = 70/189 (37%), Gaps = 60/189 (31%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI- 79
++ E ++ ++ D +T+LH A GH + LL G N G++ L +
Sbjct: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG 473
Query: 80 -------------------------AASAG------------------------------ 84
AA AG
Sbjct: 474 NENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533
Query: 85 ----RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
R +V+ LL GA V+A ++ G PLH A S +E+A +L++ GA + D ++
Sbjct: 534 AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKF 593
Query: 141 TAMHRAAAK 149
T +H AAAK
Sbjct: 594 TPLHEAAAK 602
Score = 43.1 bits (100), Expect = 9e-05
Identities = 26/93 (27%), Positives = 44/93 (47%)
Query: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
K +++ E +L + ++ T LH A H ++VE +++ VN D+ G + L
Sbjct: 378 KRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSL 437
Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110
H AA G + + LL G N ++ G T L
Sbjct: 438 HRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 85.5 bits (210), Expect = 2e-17
Identities = 51/135 (37%), Positives = 78/135 (57%), Gaps = 2/135 (1%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
AY G +E +K +++ + T D+ S T LH A S+G +V++LL LGV +N+ + G
Sbjct: 181 AYMGHIEVVK-LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANP 132
+PLH+A G+D +V L+ GA VN N+ G TPLH+AA+ + + LL G GA+
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
Query: 133 DAKDHYEATAMHRAA 147
+ K T +H A
Sbjct: 300 NMKSKDGKTPLHMTA 314
Score = 84.0 bits (206), Expect = 5e-17
Identities = 47/113 (41%), Positives = 63/113 (55%), Gaps = 1/113 (0%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D RT LH A + G+ E + LL G N KD G SPLH AA+ + + AL+G G
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461
Query: 97 AQVNAVNQNGCTPLHYAASKNRH-EIAVMLLEGGANPDAKDHYEATAMHRAAA 148
A VN +++ GCTPLHYAA+ + + LL ANP +D A+H +AA
Sbjct: 462 ASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAA 514
Score = 83.2 bits (204), Expect = 8e-17
Identities = 50/135 (37%), Positives = 72/135 (53%), Gaps = 1/135 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A+SG E +K +L+ + D+ R A+HWA GH E+V+ L+ G V KD
Sbjct: 148 AFSGHGEMVK-LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
++PLH AAS+G +VK LL G +N N G TPLH A + + L++ GA +
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266
Query: 134 AKDHYEATAMHRAAA 148
K+ T +H AAA
Sbjct: 267 QKNEKGFTPLHFAAA 281
Score = 75.5 bits (184), Expect = 2e-14
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
++G +E++ +++ K D + RT LH A G EI+E L+ G VN KD
Sbjct: 17 FNGDPDEVR-ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75
Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
+PLH A ++ +E V+ LL A VNA ++N TPLH AA+ + A L+ +N +
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 135 KDHYEATAMHRAA 147
D TA+H AA
Sbjct: 136 SDRAGRTALHHAA 148
Score = 74.3 bits (181), Expect = 4e-14
Identities = 45/135 (33%), Positives = 70/135 (51%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
++A + K + E+++ S +D+ RTALH A +GH E+V+ LL G +N D
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+H AA G E+VK L+ GA+V ++ TPLH AAS + LL+ G +
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD 231
Query: 132 PDAKDHYEATAMHRA 146
+ + Y T +H A
Sbjct: 232 MNEPNAYGNTPLHVA 246
Score = 69.3 bits (168), Expect = 1e-12
Identities = 43/129 (33%), Positives = 66/129 (51%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
EE + +L + D++ +T LH A + + E L+ L VN D AG + LH
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146
Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
AA +G E+VK LL +GA +NA ++ +H+AA E+ +L+ GA KD
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206
Query: 140 ATAMHRAAA 148
T +H AA+
Sbjct: 207 YTPLHAAAS 215
Score = 66.6 bits (161), Expect = 8e-12
Identities = 38/108 (35%), Positives = 56/108 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
LH A +G ++ LL G ++ DD G + LH AA+ G E + LL GA N +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
+ G +PLHYAA+ ++ L+ GA+ + D T +H AA DT
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDT 483
Score = 63.5 bits (153), Expect = 6e-11
Identities = 46/134 (34%), Positives = 70/134 (52%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
AY G E ++ IL+ + + D T LH A ++ E V+ LL+ VN +D
Sbjct: 49 AYLGDAEIIELLILSGARVNAK-DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW 107
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLHIAA+ + +AL+ + VN ++ G T LH+AA E+ +LL GAN +
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 134 AKDHYEATAMHRAA 147
A D + A+H AA
Sbjct: 168 AFDKKDRRAIHWAA 181
Score = 63.5 bits (153), Expect = 6e-11
Identities = 52/168 (30%), Positives = 68/168 (40%), Gaps = 35/168 (20%)
Query: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ--------------- 61
G L L +S + + D TALHWAC GH VE LL+
Sbjct: 733 GVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPL 792
Query: 62 ------------------LGVP-VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
LG VN D G +PLH AA E ++ LL AQVN+V
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852
Query: 103 NQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAK 149
+ G TPL AA + ML+ A +D+ + TA+H A +K
Sbjct: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Score = 62.0 bits (149), Expect = 2e-10
Identities = 37/125 (29%), Positives = 62/125 (49%)
Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
++I+ ++ D++ T LH A GH ++ L+ G + G PLH+AA +
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS 382
Query: 84 GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
G + + LL G ++ + G T LH AA+ E +LL GA+ + KD + + +
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Query: 144 HRAAA 148
H AAA
Sbjct: 443 HYAAA 447
Score = 61.6 bits (148), Expect = 2e-10
Identities = 35/111 (31%), Positives = 53/111 (47%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D +T LH G + ++Q G ++ +D G +PLHIAA G + ++ L+ GA
Sbjct: 304 KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+G PLH AA + LL G + D D + T +H AAA
Sbjct: 364 DTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAA 414
Score = 59.7 bits (143), Expect = 9e-10
Identities = 40/117 (34%), Positives = 62/117 (52%), Gaps = 4/117 (3%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP---VNDKD 70
A +G+ ++ + + + T D TALH ACS GH +L+ +N +
Sbjct: 864 AENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATN 923
Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP-LHYAASKNRHEIAVMLL 126
A +PLH+AA G +V+ LLGKGA V AV++NG TP L A +K+ + ++L
Sbjct: 924 AALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 59.3 bits (142), Expect = 1e-09
Identities = 40/114 (35%), Positives = 57/114 (50%), Gaps = 4/114 (3%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + +T L + GHT+ V LL G V+ KD G + LH A G +E V ALL G
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG----ANPDAKDHYEATAMHRA 146
A+ + G TP+H +A+ + LL+ ANP D++ TA+H A
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWA 763
Score = 58.9 bits (141), Expect = 2e-09
Identities = 43/138 (31%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND---KD 70
A+ G +E + I S+ + RT +H A + GH+E + L+ P N +D
Sbjct: 591 AFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQD 650
Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
G +PL ++ G + V +LL KGA V+A ++ G T LH A E LL+ GA
Sbjct: 651 GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
Query: 131 NPDAKDHYEATAMHRAAA 148
+D T +H +AA
Sbjct: 711 KCLLRDSRGRTPIHLSAA 728
Score = 57.0 bits (136), Expect = 6e-09
Identities = 36/98 (36%), Positives = 53/98 (54%)
Query: 51 GHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110
G + V L+ VN +D+ +PLH AA G EI++ L+ GA+VNA + TPL
Sbjct: 19 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
H A + E +LL+ A+ +A+D T +H AAA
Sbjct: 79 HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAA 116
Score = 55.8 bits (133), Expect = 1e-08
Identities = 34/118 (28%), Positives = 60/118 (50%), Gaps = 1/118 (0%)
Query: 31 SLATRTDQDSRTALHWACSAGHTEI-VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
++ + ++ T LH+A ++ H + +E L+ G VN K G +PLH+ A GR
Sbjct: 263 AIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS 322
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ ++ GA ++ ++NG TPLH AA + L+ GA+ + + +H AA
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Score = 55.8 bits (133), Expect = 1e-08
Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 1/98 (1%)
Query: 31 SLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVK 90
S+ TD RT LH A H E ++ LL VN D G +PL +AA G+ V+
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVE 873
Query: 91 ALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
L+ A++ + + T LH A SK A+++LE
Sbjct: 874 MLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE 911
Score = 47.4 bits (111), Expect = 5e-06
Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 7/137 (5%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVN----DKDDAGWS 75
EE +++L + D RT +H + + GH ++ LLQ ++ D+ G++
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE--GGANPD 133
LH A G + V+ LL + N +PLH A + A ML++ G + +
Sbjct: 759 ALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
Query: 134 AKDHYEATAMHRAAAKD 150
A D T +H AA D
Sbjct: 818 ATDSKGRTPLHAAAFTD 834
Score = 45.1 bits (105), Expect = 2e-05
Identities = 27/93 (29%), Positives = 51/93 (54%), Gaps = 2/93 (2%)
Query: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD-EIVKALL 93
+ D+ R+ LH+A + + + + L+ G VND D+ G +PLH AA++ D + ++ LL
Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLL 492
Query: 94 GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126
A ++ G +HY+A+ H + + L+
Sbjct: 493 RNDANPGIRDKQGYNAVHYSAAYG-HRLCLQLI 524
Score = 44.3 bits (103), Expect = 4e-05
Identities = 36/124 (29%), Positives = 61/124 (49%), Gaps = 13/124 (10%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQ---LGV--------PVNDKDD-AGWSPLHIAASAG 84
D+ A+H++ + GH ++ + L V ++D D+ A SPLH+AA G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH-YEATAM 143
+ ++ L+ ++ N +G TPL AA K E +L+ GA+ KD+ + T +
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621
Query: 144 HRAA 147
H AA
Sbjct: 622 HAAA 625
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 84.7 bits (208), Expect = 3e-17
Identities = 43/103 (41%), Positives = 64/103 (62%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
LH A G+ +V+ L++ G VN D+AGW+PLH A++ G +I+ LL GA+VN N
Sbjct: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
+G PLH A + N + A +LL+ GANP+ KD + +A+ A
Sbjct: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
Score = 55.1 bits (131), Expect = 2e-08
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
N +SGK E++K + ++ S+ R + ++ A ++V ++ G VN
Sbjct: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
AGW+ LH A+ G LL GA VN TPLH A +++A +LL GA+
Sbjct: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
Query: 132 P 132
P
Sbjct: 581 P 581
Score = 53.5 bits (127), Expect = 7e-08
Identities = 30/85 (35%), Positives = 47/85 (55%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G S LH+A G +VKAL+ GA VN + G TPLH A+++ +I V L
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
Query: 126 LEGGANPDAKDHYEATAMHRAAAKD 150
L+ GA + ++ +H A A +
Sbjct: 1208 LKAGAKVNCENIDGILPLHDAVANN 1232
Score = 39.7 bits (91), Expect = 0.001
Identities = 25/81 (30%), Positives = 42/81 (51%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G + ++ AA ++V + KG VN + G T LH A+ + A L
Sbjct: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+GGA+ + K Y+ T +H A
Sbjct: 542 LKGGADVNIKGLYQITPLHDA 562
Score = 37.4 bits (85), Expect = 0.005
Identities = 26/85 (30%), Positives = 39/85 (45%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D T LH A + G +I+ LL+ G VN ++ G PLH A + + + LL G
Sbjct: 1185 DNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNG 1244
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEI 121
A N +Q + L A + E+
Sbjct: 1245 ANPNQKDQKQKSALDEADDEKMKEL 1269
Score = 31.6 bits (70), Expect = 0.27
Identities = 23/65 (35%), Positives = 29/65 (44%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
TALH A G LL+ G VN K +PLH A G ++ + LL GA
Sbjct: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
Query: 102 VNQNG 106
N +G
Sbjct: 584 RNDDG 588
Score = 30.8 bits (68), Expect = 0.46
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
K ++N N G + LH A + + L+E GA+ + D+ T +H A+
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEAS 1196
Score = 30.0 bits (66), Expect = 0.78
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 4/67 (5%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D LH A + H + E LLQ G N KD S L A DE +K LL
Sbjct: 1220 DGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGA 1275
Query: 99 VNAVNQN 105
+ VN++
Sbjct: 1276 IETVNRD 1282
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 84.7 bits (208), Expect = 3e-17
Identities = 43/103 (41%), Positives = 64/103 (62%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
LH A G+ +V+ L++ G VN D+AGW+PLH A++ G +I+ LL GA+VN N
Sbjct: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
+G PLH A + N + A +LL+ GANP+ KD + +A+ A
Sbjct: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
Score = 55.1 bits (131), Expect = 2e-08
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
N +SGK E++K + ++ S+ R + ++ A ++V ++ G VN
Sbjct: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
AGW+ LH A+ G LL GA VN TPLH A +++A +LL GA+
Sbjct: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
Query: 132 P 132
P
Sbjct: 581 P 581
Score = 53.5 bits (127), Expect = 7e-08
Identities = 30/85 (35%), Positives = 47/85 (55%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G S LH+A G +VKAL+ GA VN + G TPLH A+++ +I V L
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
Query: 126 LEGGANPDAKDHYEATAMHRAAAKD 150
L+ GA + ++ +H A A +
Sbjct: 1208 LKAGAKVNCENIDGILPLHDAVANN 1232
Score = 39.7 bits (91), Expect = 0.001
Identities = 25/81 (30%), Positives = 42/81 (51%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G + ++ AA ++V + KG VN + G T LH A+ + A L
Sbjct: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+GGA+ + K Y+ T +H A
Sbjct: 542 LKGGADVNIKGLYQITPLHDA 562
Score = 37.4 bits (85), Expect = 0.005
Identities = 26/85 (30%), Positives = 39/85 (45%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D T LH A + G +I+ LL+ G VN ++ G PLH A + + + LL G
Sbjct: 1185 DNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNG 1244
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEI 121
A N +Q + L A + E+
Sbjct: 1245 ANPNQKDQKQKSALDEADDEKMKEL 1269
Score = 31.6 bits (70), Expect = 0.27
Identities = 23/65 (35%), Positives = 29/65 (44%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
TALH A G LL+ G VN K +PLH A G ++ + LL GA
Sbjct: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
Query: 102 VNQNG 106
N +G
Sbjct: 584 RNDDG 588
Score = 30.8 bits (68), Expect = 0.46
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
K ++N N G + LH A + + L+E GA+ + D+ T +H A+
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEAS 1196
Score = 30.0 bits (66), Expect = 0.78
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 4/67 (5%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D LH A + H + E LLQ G N KD S L A DE +K LL
Sbjct: 1220 DGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGA 1275
Query: 99 VNAVNQN 105
+ VN++
Sbjct: 1276 IETVNRD 1282
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 84.7 bits (208), Expect = 3e-17
Identities = 43/103 (41%), Positives = 64/103 (62%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
LH A G+ +V+ L++ G VN D+AGW+PLH A++ G +I+ LL GA+VN N
Sbjct: 1159 LHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVNCEN 1218
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
+G PLH A + N + A +LL+ GANP+ KD + +A+ A
Sbjct: 1219 IDGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA 1261
Score = 55.1 bits (131), Expect = 2e-08
Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
N +SGK E++K + ++ S+ R + ++ A ++V ++ G VN
Sbjct: 462 NEQFSGKKEKMKVNKISLHSI-NRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSY 520
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
AGW+ LH A+ G LL GA VN TPLH A +++A +LL GA+
Sbjct: 521 AGWTALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGAD 580
Query: 132 P 132
P
Sbjct: 581 P 581
Score = 53.5 bits (127), Expect = 7e-08
Identities = 30/85 (35%), Positives = 47/85 (55%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G S LH+A G +VKAL+ GA VN + G TPLH A+++ +I V L
Sbjct: 1148 INKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEASNEGSIDIIVEL 1207
Query: 126 LEGGANPDAKDHYEATAMHRAAAKD 150
L+ GA + ++ +H A A +
Sbjct: 1208 LKAGAKVNCENIDGILPLHDAVANN 1232
Score = 39.7 bits (91), Expect = 0.001
Identities = 25/81 (30%), Positives = 42/81 (51%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N ++ G + ++ AA ++V + KG VN + G T LH A+ + A L
Sbjct: 482 INRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQPSYAGWTALHEASVGGFYRTASEL 541
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+GGA+ + K Y+ T +H A
Sbjct: 542 LKGGADVNIKGLYQITPLHDA 562
Score = 37.4 bits (85), Expect = 0.005
Identities = 26/85 (30%), Positives = 39/85 (45%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D T LH A + G +I+ LL+ G VN ++ G PLH A + + + LL G
Sbjct: 1185 DNAGWTPLHEASNEGSIDIIVELLKAGAKVNCENIDGILPLHDAVANNHLKAAEILLQNG 1244
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEI 121
A N +Q + L A + E+
Sbjct: 1245 ANPNQKDQKQKSALDEADDEKMKEL 1269
Score = 31.6 bits (70), Expect = 0.27
Identities = 23/65 (35%), Positives = 29/65 (44%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
TALH A G LL+ G VN K +PLH A G ++ + LL GA
Sbjct: 524 TALHEASVGGFYRTASELLKGGADVNIKGLYQITPLHDAVMNGHYKVAELLLLNGADPLF 583
Query: 102 VNQNG 106
N +G
Sbjct: 584 RNDDG 588
Score = 30.8 bits (68), Expect = 0.46
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
K ++N N G + LH A + + L+E GA+ + D+ T +H A+
Sbjct: 1144 KAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADVNLNDNAGWTPLHEAS 1196
Score = 30.0 bits (66), Expect = 0.78
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 4/67 (5%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D LH A + H + E LLQ G N KD S L A DE +K LL
Sbjct: 1220 DGILPLHDAVANNHLKAAEILLQNGANPNQKDQKQKSALDEA----DDEKMKELLRSYGA 1275
Query: 99 VNAVNQN 105
+ VN++
Sbjct: 1276 IETVNRD 1282
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 84.7 bits (208), Expect = 3e-17
Identities = 46/128 (35%), Positives = 69/128 (53%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +LA + D+ R ALHWA GH ++V L+ G V KD G++PLH A
Sbjct: 129 EMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAA 188
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
AS G+ +VK LL G +++ +N G T LH A + + L++ GAN + ++
Sbjct: 189 ASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
Query: 141 TAMHRAAA 148
T +H AAA
Sbjct: 249 TPLHFAAA 256
Score = 74.7 bits (182), Expect = 3e-14
Identities = 48/135 (35%), Positives = 67/135 (49%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
++A + K + E I+ S +D+ RTALH A GH E+V LL G +N D
Sbjct: 87 HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDK 146
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
LH AA G ++V L+ GA+V ++ G TPLH AAS + + LL G
Sbjct: 147 KDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206
Query: 132 PDAKDHYEATAMHRA 146
D + Y TA+H A
Sbjct: 207 IDEINVYGNTALHIA 221
Score = 73.9 bits (180), Expect = 5e-14
Identities = 48/137 (35%), Positives = 72/137 (52%), Gaps = 7/137 (5%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
AY G L+ + ++ + T D+ T LH A S G +V+ LL LGV +++ + G
Sbjct: 156 AYMGHLDVVA-LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV-MLLEGGA-- 130
+ LHIA G+D +V L+ GA VN N NG TPLH+AA+ + + +L+ GA
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 131 ---NPDAKDHYEATAMH 144
+ D K TA+H
Sbjct: 275 NIQSKDGKSPLHMTAVH 291
Score = 72.4 bits (176), Expect = 1e-13
Identities = 41/111 (36%), Positives = 62/111 (55%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + RT LH A G EI+E L+ G VN KD+ +PLH A ++ +E V+ L+
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A VNA ++N TPLH AA+ + A +++ ++ + D TA+H AA
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
Score = 67.0 bits (162), Expect = 6e-12
Identities = 39/107 (36%), Positives = 54/107 (50%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
LH A H++ LL G ++ D G + LH AA+ G E +K L GA + +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+ G TPLHYAA+ L+ GAN + D + TA+H AAA D
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Score = 66.2 bits (160), Expect = 1e-11
Identities = 41/135 (30%), Positives = 66/135 (48%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A + + EE + ++ + D++ +T LH A + + E ++ L VN D G
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ LH AA G E+V LL KGA +NA ++ LH+AA ++ +L+ GA
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 134 AKDHYEATAMHRAAA 148
KD T +H AA+
Sbjct: 176 CKDKKGYTPLHAAAS 190
Score = 65.1 bits (157), Expect = 2e-11
Identities = 46/139 (33%), Positives = 66/139 (47%), Gaps = 3/139 (2%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG---VPVNDKD 70
A+ G E ++ I S+ + + RT LH + GHT + LL++ V+ KD
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
G +PL +A + G + V LL K A V+ V+ GCT LH E MLLE
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
Query: 131 NPDAKDHYEATAMHRAAAK 149
+ KD T +H AAA+
Sbjct: 703 SILCKDSRGRTPLHYAAAR 721
Score = 64.3 bits (155), Expect = 4e-11
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI-VKALLGKGAQVN 100
TALH AC G +V L+ G VN ++ G++PLH AA++ + ++ L+ GA VN
Sbjct: 216 TALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVN 275
Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+++G +PLH A R + L++ G D D T +H AA
Sbjct: 276 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 322
Score = 59.7 bits (143), Expect = 9e-10
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 28/140 (20%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D+ RT LH A + G+ E ++ L G + KD G +PLH AA+ ++ L+ G
Sbjct: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436
Query: 97 AQVNAVNQNGCTPLHYAASK----------NRHE------------------IAVMLLEG 128
A VN + G T LHYAA+ N H+ LL+
Sbjct: 437 ANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQN 496
Query: 129 GANPDAKDHYEATAMHRAAA 148
ANP +D ++H AAA
Sbjct: 497 DANPSIRDKEGYNSIHYAAA 516
Score = 57.0 bits (136), Expect = 6e-09
Identities = 32/83 (38%), Positives = 47/83 (56%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
VN D +PLH+AA G EI++ L+ GA+VNA + TPLH A + E +L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 126 LEGGANPDAKDHYEATAMHRAAA 148
++ A+ +A+D T +H AAA
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAA 91
Score = 54.7 bits (130), Expect = 3e-08
Identities = 33/111 (29%), Positives = 49/111 (44%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D ++ LH G + L+Q G ++ D G +PLH+AA G + ++ L GA
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+ PLH AA + LL G D D + T +H AAA
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAA 389
Score = 54.7 bits (130), Expect = 3e-08
Identities = 33/100 (33%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Query: 29 DKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI 88
D S+ + D RT L A A H E ++ LL+ PVN D++G + L +AA G+
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 862
Query: 89 VKALLGKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
V L+ A + +++ TPLH A SK + A+++L+
Sbjct: 863 VDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 53.9 bits (128), Expect = 5e-08
Identities = 33/95 (34%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 42 TALHWACSAGHTEI-VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
T LH+A ++ H + +E L+ G VN + G SPLH+ A GR + L+ G +++
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
V+++G TPLH AA + HE+ + L AK
Sbjct: 309 CVDKDGNTPLHVAA-RYGHELLINTLRTSGADTAK 342
Score = 53.9 bits (128), Expect = 5e-08
Identities = 35/112 (31%), Positives = 50/112 (44%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D+D T LH A GH ++ L G PLH+AA + + LL G
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+++ ++ G T LH AA+ E +L GA+ KD T +H AAA
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Score = 53.5 bits (127), Expect = 7e-08
Identities = 38/103 (36%), Positives = 58/103 (56%), Gaps = 3/103 (2%)
Query: 40 SRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99
+++ LH A GH + +E LLQ V ++ +D+ G + L +AA G E V+AL+ GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 100 NAV-NQNGCTPLHYAASKNRHEIAV-MLLEGGANPDAKDHYEA 140
N TPLH A+ N H + + +LLE NP+A D +A
Sbjct: 602 FVKDNVTKRTPLH-ASVINGHTLCLRLLLEIADNPEAVDVKDA 643
Score = 51.6 bits (122), Expect = 2e-07
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG--WSPLHIAA 81
E +L + + + D++ ++H+A + GH + +E LL+ ++ D+G SPLH+AA
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAA 550
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY-EA 140
G + ++ LL ++ ++ G T L AA K E L+ GA+ KD+ +
Sbjct: 551 YNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR 610
Query: 141 TAMH 144
T +H
Sbjct: 611 TPLH 614
Score = 50.4 bits (119), Expect = 6e-07
Identities = 36/126 (28%), Positives = 59/126 (46%), Gaps = 7/126 (5%)
Query: 7 NLMVCNLAYSGKL---EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG 63
+++ C + G + EE + +L + D RT LH+A + GH + LLQ+
Sbjct: 675 DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMA 734
Query: 64 VPVND---KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
+ D KD+ G++PLH A G + ++ LL + + N TPLH A +
Sbjct: 735 LSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCAIINDHGN 793
Query: 121 IAVMLL 126
A +LL
Sbjct: 794 CASLLL 799
Score = 48.5 bits (114), Expect = 2e-06
Identities = 33/90 (36%), Positives = 44/90 (48%), Gaps = 5/90 (5%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR----DEIVKALLGKGA 97
TALH GH E V+ LL+ V + KD G +PLH AA+ G E+++ L +
Sbjct: 680 TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEED 739
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
NQ G TPLH+A +LLE
Sbjct: 740 CCFKDNQ-GYTPLHWACYNGNENCIEVLLE 768
Score = 47.8 bits (112), Expect = 4e-06
Identities = 40/156 (25%), Positives = 66/156 (42%), Gaps = 30/156 (19%)
Query: 24 ESILADKSLATRTDQDSRTALHWACSAGH----------------------------TEI 55
E+++ + TD RTALH+A ++ T
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489
Query: 56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCT--PLHYA 113
+EFLLQ + +D G++ +H AA+ G + ++ LL + + +G T PLH A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
A H+ +LL+ + D +D TA+ AA K
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585
Score = 46.6 bits (109), Expect = 8e-06
Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 18/138 (13%)
Query: 19 LEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ-------LGVPVNDKDD 71
L EL + L+++ + D T LHWAC G+ +E LL+ +G P
Sbjct: 727 LSELLQMALSEEDCCFK-DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP------ 779
Query: 72 AGWSPLHIAASAGRDEIVKALLGK--GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129
++PLH A LLG + V+ + G TPL AA + E +LL
Sbjct: 780 --FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS 837
Query: 130 ANPDAKDHYEATAMHRAA 147
A +A D+ TA+ AA
Sbjct: 838 APVNAVDNSGKTALMMAA 855
Score = 40.8 bits (94), Expect = 4e-04
Identities = 23/57 (40%), Positives = 31/57 (54%)
Query: 92 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
L+ K VN ++ TPLH AA EI +L+ GA +AKD+ T +HRA A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVA 58
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 84.0 bits (206), Expect = 5e-17
Identities = 49/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
SN A +G L+++ E + + T +Q+ ALH A GH +V+ LL G
Sbjct: 10 SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
V+ G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N ++ L
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 126 LEGGAN 131
LE GAN
Sbjct: 129 LENGAN 134
Score = 80.9 bits (198), Expect = 4e-16
Identities = 46/142 (32%), Positives = 73/142 (51%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
+ L ++A G E + +L K+ D TALH A GH + + LL
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
N + G++PLHIA R ++++ L+ GA + A+ ++G TP+H AA I ++L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 126 LEGGANPDAKDHYEATAMHRAA 147
L+ GA+PD + TA+H AA
Sbjct: 430 LQNGASPDVTNIRGETALHMAA 451
Score = 75.5 bits (184), Expect = 2e-14
Identities = 42/121 (34%), Positives = 62/121 (51%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K + RT + T LH A G+ + LL G V+ G +PLH+A+ G +V
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 261
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
K LL +G Q++A ++G TPLH AA ++ +LLE GA A+ + +H AA
Sbjct: 262 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321
Query: 150 D 150
D
Sbjct: 322 D 322
Score = 74.3 bits (181), Expect = 4e-14
Identities = 39/109 (35%), Positives = 61/109 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH + G ++ LL+ G + G++PLH+AA G ++ K LL + A ++
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+NG TPLH AA + ++A++LLE GA+P A T +H AA K+
Sbjct: 571 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619
Score = 73.6 bits (179), Expect = 6e-14
Identities = 43/113 (38%), Positives = 61/113 (53%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D T LH A +GH ++VE LL+ G P+ + G SPLH+AA E VK LL A
Sbjct: 276 RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 335
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V+ V + T LH AA + + +LL+ ANP+A+ T +H A K+
Sbjct: 336 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
Score = 72.4 bits (176), Expect = 1e-13
Identities = 44/112 (39%), Positives = 61/112 (54%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T+ TALH A AG E+V LL+ G V+ + +PLHIA+ G+ EIV+ LL
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A +A NG TPLH +A + + ++A +LLE GA T +H AA
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 550
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/130 (30%), Positives = 67/130 (51%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
++ + +L ++ A ++ T LH A + ++ LL+ G + G++PLHIA
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A + +I LL GA+ N V + G TPLH A+ + ++ +LL+ GAN
Sbjct: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675
Query: 141 TAMHRAAAKD 150
T++H AA +D
Sbjct: 676 TSLHLAAQED 685
Score = 70.9 bits (172), Expect = 4e-13
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
L + +L S + TALH A AG E+V+ L++ G +N + G++PL++AA
Sbjct: 58 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 117
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
++VK LL GA + ++G TPL A + ++ +LLE D K
Sbjct: 118 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLP 173
Query: 142 AMHRAAAKD 150
A+H AA KD
Sbjct: 174 ALHIAARKD 182
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/112 (38%), Positives = 62/112 (55%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A G+T +V+ LL G ++ K G +PLH AA +G D++V+ LL +
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +PLH AA + E LL+ A D TA+H AA
Sbjct: 301 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 352
Score = 69.7 bits (169), Expect = 9e-13
Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 1/137 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G++E ++ +L + +L ++ +T LH A G TEIV+ LLQ + G
Sbjct: 451 ARAGQVEVVR-CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 509
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
++PLHI+A G+ ++ LL GA + + G TPLH AA ++A +LL+ A D
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 134 AKDHYEATAMHRAAAKD 150
+ T +H AA D
Sbjct: 570 SAGKNGLTPLHVAAHYD 586
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/120 (36%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A SLAT+ T LH A G ++ + LLQ + G +PLH+AA +
Sbjct: 533 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ LL KGA +A +NG TPLH AA KN+ +IA LL GA + T +H A+
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649
Score = 68.2 bits (165), Expect = 3e-12
Identities = 38/106 (35%), Positives = 55/106 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC +++E L++ G + ++G +P+H+AA G IV LL GA +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N G T LH AA + E+ LL GA DA+ E T +H A+
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 484
Score = 67.4 bits (163), Expect = 4e-12
Identities = 42/106 (39%), Positives = 59/106 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T +H A GH IV LLQ G + + G + LH+AA AG+ E+V+ LL GA V+A
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ TPLH A+ + EI +LL+ A+PDA T +H +A
Sbjct: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA 517
Score = 63.5 bits (153), Expect = 6e-11
Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 8/113 (7%)
Query: 43 ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
ALH A T+ LLQ + VN ++G++PLHIAA G + LL
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+GA V+ +NG TPLH A+ + + +LL+ G DAK T +H AA
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
Score = 63.2 bits (152), Expect = 8e-11
Identities = 34/99 (34%), Positives = 53/99 (53%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A +I LL G N G +PLH+A+ G ++V LL K
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
GA ++ ++G T LH AA +++ +A +L + GA+ DA
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Score = 62.8 bits (151), Expect = 1e-10
Identities = 36/102 (35%), Positives = 53/102 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T+LH A + + L + G + G++PL +A G ++V LL +GA VNA
Sbjct: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
+NG TPLH AA + I +LL+ GA P+A TA+
Sbjct: 736 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 62.0 bits (149), Expect = 2e-10
Identities = 35/112 (31%), Positives = 63/112 (56%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
DS + A AG+ + V L+ G+ +N + G + LH+AA G +V+ LLG+G+
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V++ + G T LH A+ + E+ +L++ GAN +A+ T ++ AA ++
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 120
Score = 60.1 bits (144), Expect = 7e-10
Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 5/82 (6%)
Query: 37 DQDSRTALHW-----ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
DQD+ T L + AC G+ ++V FLL+ G VN K G++PLH AA G I+
Sbjct: 699 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 758
Query: 92 LLGKGAQVNAVNQNGCTPLHYA 113
LL GA+ NA NG T L A
Sbjct: 759 LLQHGAKPNATTANGNTALAIA 780
Score = 59.3 bits (142), Expect = 1e-09
Identities = 36/106 (33%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GHT++V LL G ++ +G + LH+AA + + L GA +A
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPL A ++ LL+ GAN +AK T +H+AA
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
Score = 32.7 bits (73), Expect = 0.12
Identities = 20/51 (39%), Positives = 23/51 (45%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
T LH A GHT I+ LLQ G N G + L IA G +V L
Sbjct: 742 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 84.0 bits (206), Expect = 5e-17
Identities = 49/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
SN A +G L+++ E + + T +Q+ ALH A GH +V+ LL G
Sbjct: 31 SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
V+ G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N ++ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 126 LEGGAN 131
LE GAN
Sbjct: 150 LENGAN 155
Score = 80.9 bits (198), Expect = 4e-16
Identities = 46/142 (32%), Positives = 73/142 (51%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
+ L ++A G E + +L K+ D TALH A GH + + LL
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
N + G++PLHIA R ++++ L+ GA + A+ ++G TP+H AA I ++L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 126 LEGGANPDAKDHYEATAMHRAA 147
L+ GA+PD + TA+H AA
Sbjct: 451 LQNGASPDVTNIRGETALHMAA 472
Score = 75.5 bits (184), Expect = 2e-14
Identities = 42/121 (34%), Positives = 62/121 (51%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K + RT + T LH A G+ + LL G V+ G +PLH+A+ G +V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
K LL +G Q++A ++G TPLH AA ++ +LLE GA A+ + +H AA
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 150 D 150
D
Sbjct: 343 D 343
Score = 74.3 bits (181), Expect = 4e-14
Identities = 39/109 (35%), Positives = 61/109 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH + G ++ LL+ G + G++PLH+AA G ++ K LL + A ++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+NG TPLH AA + ++A++LLE GA+P A T +H AA K+
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640
Score = 73.6 bits (179), Expect = 6e-14
Identities = 43/113 (38%), Positives = 61/113 (53%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D T LH A +GH ++VE LL+ G P+ + G SPLH+AA E VK LL A
Sbjct: 297 RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V+ V + T LH AA + + +LL+ ANP+A+ T +H A K+
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Score = 72.4 bits (176), Expect = 1e-13
Identities = 44/112 (39%), Positives = 61/112 (54%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T+ TALH A AG E+V LL+ G V+ + +PLHIA+ G+ EIV+ LL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A +A NG TPLH +A + + ++A +LLE GA T +H AA
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/130 (30%), Positives = 67/130 (51%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
++ + +L ++ A ++ T LH A + ++ LL+ G + G++PLHIA
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A + +I LL GA+ N V + G TPLH A+ + ++ +LL+ GAN
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
Query: 141 TAMHRAAAKD 150
T++H AA +D
Sbjct: 697 TSLHLAAQED 706
Score = 70.9 bits (172), Expect = 4e-13
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
L + +L S + TALH A AG E+V+ L++ G +N + G++PL++AA
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
++VK LL GA + ++G TPL A + ++ +LLE D K
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLP 194
Query: 142 AMHRAAAKD 150
A+H AA KD
Sbjct: 195 ALHIAARKD 203
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/112 (38%), Positives = 62/112 (55%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A G+T +V+ LL G ++ K G +PLH AA +G D++V+ LL +
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +PLH AA + E LL+ A D TA+H AA
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Score = 69.7 bits (169), Expect = 9e-13
Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 1/137 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G++E ++ +L + +L ++ +T LH A G TEIV+ LLQ + G
Sbjct: 472 ARAGQVEVVR-CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
++PLHI+A G+ ++ LL GA + + G TPLH AA ++A +LL+ A D
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 134 AKDHYEATAMHRAAAKD 150
+ T +H AA D
Sbjct: 591 SAGKNGLTPLHVAAHYD 607
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/120 (36%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A SLAT+ T LH A G ++ + LLQ + G +PLH+AA +
Sbjct: 554 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ LL KGA +A +NG TPLH AA KN+ +IA LL GA + T +H A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Score = 68.2 bits (165), Expect = 3e-12
Identities = 38/106 (35%), Positives = 55/106 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC +++E L++ G + ++G +P+H+AA G IV LL GA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N G T LH AA + E+ LL GA DA+ E T +H A+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Score = 67.4 bits (163), Expect = 4e-12
Identities = 42/106 (39%), Positives = 59/106 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T +H A GH IV LLQ G + + G + LH+AA AG+ E+V+ LL GA V+A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ TPLH A+ + EI +LL+ A+PDA T +H +A
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA 538
Score = 63.5 bits (153), Expect = 6e-11
Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 8/113 (7%)
Query: 43 ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
ALH A T+ LLQ + VN ++G++PLHIAA G + LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+GA V+ +NG TPLH A+ + + +LL+ G DAK T +H AA
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Score = 63.2 bits (152), Expect = 8e-11
Identities = 34/99 (34%), Positives = 53/99 (53%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A +I LL G N G +PLH+A+ G ++V LL K
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
GA ++ ++G T LH AA +++ +A +L + GA+ DA
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Score = 62.8 bits (151), Expect = 1e-10
Identities = 36/102 (35%), Positives = 53/102 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T+LH A + + L + G + G++PL +A G ++V LL +GA VNA
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
+NG TPLH AA + I +LL+ GA P+A TA+
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 62.0 bits (149), Expect = 2e-10
Identities = 35/112 (31%), Positives = 63/112 (56%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
DS + A AG+ + V L+ G+ +N + G + LH+AA G +V+ LLG+G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V++ + G T LH A+ + E+ +L++ GAN +A+ T ++ AA ++
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 141
Score = 60.1 bits (144), Expect = 7e-10
Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 5/82 (6%)
Query: 37 DQDSRTALHW-----ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
DQD+ T L + AC G+ ++V FLL+ G VN K G++PLH AA G I+
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 92 LLGKGAQVNAVNQNGCTPLHYA 113
LL GA+ NA NG T L A
Sbjct: 780 LLQHGAKPNATTANGNTALAIA 801
Score = 59.3 bits (142), Expect = 1e-09
Identities = 36/106 (33%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GHT++V LL G ++ +G + LH+AA + + L GA +A
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPL A ++ LL+ GAN +AK T +H+AA
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Score = 32.7 bits (73), Expect = 0.12
Identities = 20/51 (39%), Positives = 23/51 (45%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
T LH A GHT I+ LLQ G N G + L IA G +V L
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 84.0 bits (206), Expect = 5e-17
Identities = 49/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
SN A +G L+++ E + + T +Q+ ALH A GH +V+ LL G
Sbjct: 31 SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
V+ G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N ++ L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 126 LEGGAN 131
LE GAN
Sbjct: 150 LENGAN 155
Score = 80.9 bits (198), Expect = 4e-16
Identities = 46/142 (32%), Positives = 73/142 (51%)
Query: 6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
+ L ++A G E + +L K+ D TALH A GH + + LL
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
N + G++PLHIA R ++++ L+ GA + A+ ++G TP+H AA I ++L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 126 LEGGANPDAKDHYEATAMHRAA 147
L+ GA+PD + TA+H AA
Sbjct: 451 LQNGASPDVTNIRGETALHMAA 472
Score = 75.5 bits (184), Expect = 2e-14
Identities = 42/121 (34%), Positives = 62/121 (51%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K + RT + T LH A G+ + LL G V+ G +PLH+A+ G +V
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
K LL +G Q++A ++G TPLH AA ++ +LLE GA A+ + +H AA
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 150 D 150
D
Sbjct: 343 D 343
Score = 74.3 bits (181), Expect = 4e-14
Identities = 39/109 (35%), Positives = 61/109 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH + G ++ LL+ G + G++PLH+AA G ++ K LL + A ++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+NG TPLH AA + ++A++LLE GA+P A T +H AA K+
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640
Score = 73.6 bits (179), Expect = 6e-14
Identities = 43/113 (38%), Positives = 61/113 (53%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D T LH A +GH ++VE LL+ G P+ + G SPLH+AA E VK LL A
Sbjct: 297 RDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V+ V + T LH AA + + +LL+ ANP+A+ T +H A K+
Sbjct: 357 PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Score = 72.4 bits (176), Expect = 1e-13
Identities = 44/112 (39%), Positives = 61/112 (54%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T+ TALH A AG E+V LL+ G V+ + +PLHIA+ G+ EIV+ LL
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A +A NG TPLH +A + + ++A +LLE GA T +H AA
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Score = 71.2 bits (173), Expect = 3e-13
Identities = 39/130 (30%), Positives = 67/130 (51%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
++ + +L ++ A ++ T LH A + ++ LL+ G + G++PLHIA
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A + +I LL GA+ N V + G TPLH A+ + ++ +LL+ GAN
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696
Query: 141 TAMHRAAAKD 150
T++H AA +D
Sbjct: 697 TSLHLAAQED 706
Score = 70.9 bits (172), Expect = 4e-13
Identities = 42/129 (32%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
L + +L S + TALH A AG E+V+ L++ G +N + G++PL++AA
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 138
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
++VK LL GA + ++G TPL A + ++ +LLE D K
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLP 194
Query: 142 AMHRAAAKD 150
A+H AA KD
Sbjct: 195 ALHIAARKD 203
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/112 (38%), Positives = 62/112 (55%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A G+T +V+ LL G ++ K G +PLH AA +G D++V+ LL +
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +PLH AA + E LL+ A D TA+H AA
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Score = 69.7 bits (169), Expect = 9e-13
Identities = 45/137 (32%), Positives = 72/137 (52%), Gaps = 1/137 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G++E ++ +L + +L ++ +T LH A G TEIV+ LLQ + G
Sbjct: 472 ARAGQVEVVR-CLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG 530
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
++PLHI+A G+ ++ LL GA + + G TPLH AA ++A +LL+ A D
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 134 AKDHYEATAMHRAAAKD 150
+ T +H AA D
Sbjct: 591 SAGKNGLTPLHVAAHYD 607
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/120 (36%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A SLAT+ T LH A G ++ + LLQ + G +PLH+AA +
Sbjct: 554 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ LL KGA +A +NG TPLH AA KN+ +IA LL GA + T +H A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Score = 68.2 bits (165), Expect = 3e-12
Identities = 38/106 (35%), Positives = 55/106 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC +++E L++ G + ++G +P+H+AA G IV LL GA +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N G T LH AA + E+ LL GA DA+ E T +H A+
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Score = 67.4 bits (163), Expect = 4e-12
Identities = 42/106 (39%), Positives = 59/106 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T +H A GH IV LLQ G + + G + LH+AA AG+ E+V+ LL GA V+A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ TPLH A+ + EI +LL+ A+PDA T +H +A
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA 538
Score = 63.5 bits (153), Expect = 6e-11
Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 8/113 (7%)
Query: 43 ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
ALH A T+ LLQ + VN ++G++PLHIAA G + LL
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+GA V+ +NG TPLH A+ + + +LL+ G DAK T +H AA
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Score = 63.2 bits (152), Expect = 8e-11
Identities = 34/99 (34%), Positives = 53/99 (53%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A +I LL G N G +PLH+A+ G ++V LL K
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
GA ++ ++G T LH AA +++ +A +L + GA+ DA
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Score = 62.8 bits (151), Expect = 1e-10
Identities = 36/102 (35%), Positives = 53/102 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T+LH A + + L + G + G++PL +A G ++V LL +GA VNA
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
+NG TPLH AA + I +LL+ GA P+A TA+
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 62.0 bits (149), Expect = 2e-10
Identities = 35/112 (31%), Positives = 63/112 (56%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
DS + A AG+ + V L+ G+ +N + G + LH+AA G +V+ LLG+G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V++ + G T LH A+ + E+ +L++ GAN +A+ T ++ AA ++
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN 141
Score = 60.1 bits (144), Expect = 7e-10
Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 5/82 (6%)
Query: 37 DQDSRTALHW-----ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
DQD+ T L + AC G+ ++V FLL+ G VN K G++PLH AA G I+
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 92 LLGKGAQVNAVNQNGCTPLHYA 113
LL GA+ NA NG T L A
Sbjct: 780 LLQHGAKPNATTANGNTALAIA 801
Score = 59.3 bits (142), Expect = 1e-09
Identities = 36/106 (33%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GHT++V LL G ++ +G + LH+AA + + L GA +A
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPL A ++ LL+ GAN +AK T +H+AA
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Score = 32.7 bits (73), Expect = 0.12
Identities = 20/51 (39%), Positives = 23/51 (45%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
T LH A GHT I+ LLQ G N G + L IA G +V L
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 82.4 bits (202), Expect = 1e-16
Identities = 51/135 (37%), Positives = 73/135 (54%), Gaps = 12/135 (8%)
Query: 14 AYSGKLEELKESI----------LADKSLATRTDQDSRTA--LHWACSAGHTEIVEFLLQ 61
A SG L EL E+ L D + D R + LH+A G ++VE LLQ
Sbjct: 178 AVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
+G V+ +DD G PLH A S G E+V LL +GA NA + TPLH AA K + ++
Sbjct: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 297
Query: 122 AVMLLEGGANPDAKD 136
++LL+ GA+P+ ++
Sbjct: 298 CIVLLQHGADPNIRN 312
Score = 78.6 bits (192), Expect = 2e-15
Identities = 52/133 (39%), Positives = 68/133 (51%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG E+L + +D T LH A IV+ LLQ G V+ KD G
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
PLH A S G E+ + LL GA VNA++ TPLH AASKNR E+ +LL GA+P
Sbjct: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462
Query: 134 AKDHYEATAMHRA 146
+ + +A+ A
Sbjct: 463 LVNCHGKSAVDMA 475
Score = 78.2 bits (191), Expect = 2e-15
Identities = 47/136 (34%), Positives = 68/136 (50%)
Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
+G LE +K+ + + T LH+A +VE+LL G V+ KD G
Sbjct: 660 AGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719
Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
PLH A S G E+ + L+ GA VN + TPLH AA+K ++EI +LL+ GA+P K
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 136 DHYEATAMHRAAAKDT 151
+ T + DT
Sbjct: 780 NRDGNTPLDLVKEGDT 795
Score = 75.9 bits (185), Expect = 1e-14
Identities = 44/115 (38%), Positives = 60/115 (52%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T + T LH A + E+ E+LL+ G VN +D G PLH AAS G +I L+
Sbjct: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
VNA ++ TPLH AA K R ++ +LL GA+P K+ T + A A D
Sbjct: 893 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947
Score = 72.4 bits (176), Expect = 1e-13
Identities = 45/105 (42%), Positives = 60/105 (57%), Gaps = 3/105 (2%)
Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNAVNQ 104
AC G V+ L+ VN KD AG SPLH AA GR ++V+ LL GA V+A +
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G PLH A S E+ +LL GA+P+A+D++ T +H AA K
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIK 292
Score = 68.9 bits (167), Expect = 2e-12
Identities = 46/126 (36%), Positives = 69/126 (54%), Gaps = 2/126 (1%)
Query: 27 LADKSL-ATRTDQDSRTALHWACSAGHTE-IVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
LAD S A T + + L A +G+ E ++ L L V + D +PLH+AA
Sbjct: 321 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 380
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
R IV+ LL GA V+A ++ G PLH A S +E+ +LL+ GA +A D ++ T +H
Sbjct: 381 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH 440
Query: 145 RAAAKD 150
AA+K+
Sbjct: 441 EAASKN 446
Score = 60.8 bits (146), Expect = 4e-10
Identities = 39/122 (31%), Positives = 68/122 (55%), Gaps = 4/122 (3%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKD 70
A L ++K++ LA + + + Q TALH A ++ H ++ E LL+ G VN+K+
Sbjct: 497 AREADLAKVKKT-LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555
Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
+PLH+AA +++++ L GA++NA++ G T LH AA + +LL G+
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615
Query: 131 NP 132
+P
Sbjct: 616 DP 617
Score = 56.2 bits (134), Expect = 1e-08
Identities = 35/112 (31%), Positives = 51/112 (45%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ E +L + D+ LH A S GH +I L++ VN D ++PLH A
Sbjct: 851 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 910
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
A GR ++ LL GA NQ G TPL A + + + + + A P
Sbjct: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALP 962
Score = 55.8 bits (133), Expect = 1e-08
Identities = 40/132 (30%), Positives = 56/132 (42%), Gaps = 21/132 (15%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D LH ACS GH E+V LL G N +D+ ++PLH AA G+ ++ LL G
Sbjct: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
Query: 97 AQVNAVNQNGCTP---------------------LHYAASKNRHEIAVMLLEGGANPDAK 135
A N N +G + L A S N ++ +L N A
Sbjct: 306 ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365
Query: 136 DHYEATAMHRAA 147
D ++T +H AA
Sbjct: 366 DGRKSTPLHLAA 377
Score = 55.1 bits (131), Expect = 2e-08
Identities = 33/84 (39%), Positives = 43/84 (51%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D+ LH ACS GH E+ E LL+ G VN D ++PLH AAS R E+ LL G
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
Query: 97 AQVNAVNQNGCTPLHYAASKNRHE 120
A VN +G + + A + E
Sbjct: 459 ADPTLVNCHGKSAVDMAPTPELRE 482
Score = 50.8 bits (120), Expect = 4e-07
Identities = 29/74 (39%), Positives = 44/74 (59%), Gaps = 3/74 (4%)
Query: 77 LHIAASA---GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
LH A ++ R ++ + LL KGA VN N++ TPLH AA + +++ +L + GA +
Sbjct: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
Query: 134 AKDHYEATAMHRAA 147
A D TA+HRAA
Sbjct: 586 ALDTLGQTALHRAA 599
Score = 48.5 bits (114), Expect = 2e-06
Identities = 41/130 (31%), Positives = 57/130 (43%), Gaps = 25/130 (19%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + G EI + LL+ G K+ G +PL + G +I L G A ++A
Sbjct: 752 TPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLDA 810
Query: 102 VNQNGC-----------------------TPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138
+ GC TPLH AA N E+A LLE GA+ +A+D
Sbjct: 811 A-KKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 139 EATAMHRAAA 148
+H AA+
Sbjct: 870 GLIPLHNAAS 879
Score = 45.4 bits (106), Expect = 2e-05
Identities = 26/91 (28%), Positives = 45/91 (49%)
Query: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
K +++ E +L + ++D T LH A H +++E L + G +N D G + L
Sbjct: 536 KRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL 595
Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCT 108
H AA AG + + LL G+ + ++ G T
Sbjct: 596 HRAALAGHLQTCRLLLSYGSDPSIISLQGFT 626
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 82.0 bits (201), Expect = 2e-16
Identities = 47/137 (34%), Positives = 75/137 (54%), Gaps = 1/137 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG+ E ++ ++ D + +D +T LH + G +IV+ LLQ G N +G
Sbjct: 474 ARSGQAEVVRY-LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
++PLH++A G +++ LL GA ++ + G TPLH AA + E+A +LL+ A+PD
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592
Query: 134 AKDHYEATAMHRAAAKD 150
A T +H AA D
Sbjct: 593 AAGKSGLTPLHVAAHYD 609
Score = 80.1 bits (196), Expect = 7e-16
Identities = 41/109 (37%), Positives = 63/109 (57%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH + GH ++ FLL G ++ G++PLH+AA G+ E+ LL K A +A
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++G TPLH AA + ++A++LL+ GA+P A T +H AA K+
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642
Score = 79.3 bits (194), Expect = 1e-15
Identities = 43/95 (45%), Positives = 58/95 (61%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
+Q+ ALH A GH E+V LLQ V+ G + LHIA+ AG+ E+VK L+ G
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
A VNA +QNG TPL+ AA +N E+ LL+ GA+
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Score = 78.2 bits (191), Expect = 2e-15
Identities = 43/112 (38%), Positives = 62/112 (55%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T+ TALH A +G E+V +L+Q G V K +PLHI+A G+ +IV+ LL +
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA NA +G TPLH +A + ++A LL+ GA+ T +H AA
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573
Score = 75.5 bits (184), Expect = 2e-14
Identities = 46/128 (35%), Positives = 66/128 (51%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
E++ E +L + ++ + LH A H V+ LLQ VPV+D + + LH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
AA G ++ K LL K A NA NG TPLH A KNR ++ +LL+ GA+ A
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 140 ATAMHRAA 147
T +H AA
Sbjct: 434 LTPIHVAA 441
Score = 74.3 bits (181), Expect = 4e-14
Identities = 41/109 (37%), Positives = 59/109 (54%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D TALH A GH ++ + LL N K G++PLHIA R ++++ LL GA
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ AV ++G TP+H AA I L+ GA+P+ + TA+H AA
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
Score = 73.9 bits (180), Expect = 5e-14
Identities = 44/128 (34%), Positives = 66/128 (51%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
E++ +L + + T + T LH A G E+ LLQ + +G +PLH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
AA ++ LL +GA +A +NG TPLH AA KN+ +IA LLE GA+ +A
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 140 ATAMHRAA 147
++H AA
Sbjct: 665 IASVHLAA 672
Score = 71.6 bits (174), Expect = 2e-13
Identities = 45/134 (33%), Positives = 70/134 (52%), Gaps = 5/134 (3%)
Query: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
G +E + E + + ++ T + + TALH A AG E+V+ L+ G VN + G++P
Sbjct: 85 GHVEVVSELLQREANVDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTP 143
Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
L++AA E+VK LL GA + ++G TPL A + ++ +LLE D K
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKG 199
Query: 137 HYEATAMHRAAAKD 150
A+H AA KD
Sbjct: 200 KVRLPALHIAARKD 213
Score = 70.5 bits (171), Expect = 5e-13
Identities = 38/103 (36%), Positives = 56/103 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A +I LL+ G N G + +H+AA G ++V LLG+ A VN
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
N++G TPLH AA ++R +A +L+ GA+ DA+ T +H
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735
Score = 70.1 bits (170), Expect = 7e-13
Identities = 37/106 (34%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC +++E LL+ G + ++G +P+H+AA G IV L+ GA N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N G T LH AA + E+ L++ GA +AK + T +H +A
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507
Score = 69.3 bits (168), Expect = 1e-12
Identities = 40/113 (35%), Positives = 57/113 (50%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
+D T LH +GH ++VE LL P+ K G SPLH+A V+ LL
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV 358
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
V+ V + T LH AA +++A +LL+ ANP+AK T +H A K+
Sbjct: 359 PVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411
Score = 68.6 bits (166), Expect = 2e-12
Identities = 41/127 (32%), Positives = 66/127 (51%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
++ E +L + + T +H A GH IV L+ G N + G + LH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A +G+ E+V+ L+ GAQV A ++ TPLH +A + +I LL+ GA+P+A
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 141 TAMHRAA 147
T +H +A
Sbjct: 534 TPLHLSA 540
Score = 66.6 bits (161), Expect = 8e-12
Identities = 40/120 (33%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
AD + TR ++H A GH ++V LL VN + +G +PLH+AA R
Sbjct: 655 ADANAVTR---QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + L+ +GA V+A + G TPLH +I LL+ A +AK T +H+AA
Sbjct: 712 VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAA 771
Score = 65.1 bits (157), Expect = 2e-11
Identities = 34/98 (34%), Positives = 52/98 (53%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
+++ T LH A + E L+ G V+ + G++PLH+ G +IV LL
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
A+VNA +NG TPLH AA + I +LL+ A+P+
Sbjct: 753 SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Score = 63.2 bits (152), Expect = 8e-11
Identities = 35/112 (31%), Positives = 58/112 (51%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T ++ T LH A G+ +V+ LL G ++ K G +PLH A +G +++V+ LL +
Sbjct: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A + + +NG +PLH A + +LL+ D + TA+H AA
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375
Score = 60.8 bits (146), Expect = 4e-10
Identities = 36/105 (34%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T+ LLQ + + +G++PLHIAA G + LL + A V+
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+N TPLH A+ + + +LL+ GA DAK T +H A
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Score = 60.5 bits (145), Expect = 5e-10
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 1/134 (0%)
Query: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
GKLE + +L + + T LH A + ++ LL G + G++P
Sbjct: 576 GKLE-VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
LHIAA + +I LL GA NAV + G +H AA + ++ +LL AN + +
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
Query: 137 HYEATAMHRAAAKD 150
T +H AA +D
Sbjct: 695 KSGLTPLHLAAQED 708
Score = 60.1 bits (144), Expect = 7e-10
Identities = 36/121 (29%), Positives = 62/121 (51%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
+S + D+ + A AGH E ++ GV +N + G + LH+A+ G E+V
Sbjct: 31 RSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV 90
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
LL + A V+A + G T LH A+ + E+ +L+ GAN +A+ T ++ AA +
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 150 D 150
+
Sbjct: 151 N 151
Score = 59.3 bits (142), Expect = 1e-09
Identities = 34/109 (31%), Positives = 53/109 (48%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A G+ + LL V+ +PLH+A+ G +VK LL +GA+++A
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++G TPLH A ++ MLL+ A +K + +H A D
Sbjct: 297 KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345
Score = 55.5 bits (132), Expect = 2e-08
Identities = 31/72 (43%), Positives = 37/72 (51%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH C G+ +IV FLLQ VN K G++PLH AA G I+ LL A N
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 102 VNQNGCTPLHYA 113
+ NG T L A
Sbjct: 792 LTVNGNTALGIA 803
Score = 50.1 bits (118), Expect = 7e-07
Identities = 40/158 (25%), Positives = 64/158 (40%), Gaps = 29/158 (18%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ + ++ + + Q+ T L+ A H E+V+FLL G + + G++PL +A
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
Query: 81 ASAGRDEIVKALLG---------------------KGAQVNAVNQN--------GCTPLH 111
G D++V LL K A + N N G TPLH
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
Query: 112 YAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
AA +A +LL A D + T +H A+ +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKR 278
Score = 31.2 bits (69), Expect = 0.35
Identities = 19/51 (37%), Positives = 23/51 (45%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
T LH A GHT I+ LLQ N+ G + L IA G +V L
Sbjct: 765 TPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 82.0 bits (201), Expect = 2e-16
Identities = 49/127 (38%), Positives = 69/127 (54%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
E L + L D D+ RTALHWAC GH+++V LL G V+ +D +P+
Sbjct: 124 EYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFW 183
Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
A G I+K LL +GA+VNA ++ G TPLH A + L+E GA+ +A+D
Sbjct: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243
Query: 140 ATAMHRA 146
TA+H A
Sbjct: 244 DTALHEA 250
Score = 64.3 bits (155), Expect = 4e-11
Identities = 38/126 (30%), Positives = 60/126 (47%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
+L +L + D RT + WAC GH I++ LL G VN +D G +PLH+A
Sbjct: 158 QLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVA 217
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
+ ++ L+ GA +NA ++ G T LH A ++ +LL GA ++
Sbjct: 218 VRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASV 277
Query: 141 TAMHRA 146
T + A
Sbjct: 278 TPVQLA 283
Score = 43.9 bits (102), Expect = 5e-05
Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Query: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
G L LK+ +L + D+ T LH A H + +E L++ G +N +D G +
Sbjct: 188 GHLVILKQ-LLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTA 246
Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118
LH A G + +K LL GA++ N TP+ A R
Sbjct: 247 LHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQR 288
Score = 26.9 bits (58), Expect = 6.6
Identities = 13/37 (35%), Positives = 20/37 (54%)
Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
AA++N+ + L G +P+A D TA+H A K
Sbjct: 118 AAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLK 154
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 80.5 bits (197), Expect = 5e-16
Identities = 53/145 (36%), Positives = 75/145 (51%), Gaps = 3/145 (2%)
Query: 5 VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
VSN+ V ++A E+ + +L +K+ +D +T LH A GHT +V+ LL+
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
N AG +PLHIAA G E V ALL K A + + G TPLH AA + +
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 122 AVMLLEGGANPDAKDHYEATAMHRA 146
A +LLE A+P+A T +H A
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVA 609
Score = 77.4 bits (189), Expect = 4e-15
Identities = 46/118 (38%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG L++ + + + T +Q+ LH A GH ++V LL + + G
Sbjct: 53 ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+ LHIAA AG+DE+V+ L+ GA VNA +Q G TPL+ AA +N E+ LLE GAN
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
Score = 76.6 bits (187), Expect = 7e-15
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Query: 26 ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
+L D+ T +D T LH A GH I E LL G P+ K G SP+H+AA
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
+ V+ LL A+++ + + TPLH AA H +A +LL+ GA P+++ T +H
Sbjct: 350 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
Query: 145 RAAAKD 150
A K+
Sbjct: 410 IACKKN 415
Score = 75.9 bits (185), Expect = 1e-14
Identities = 42/106 (39%), Positives = 58/106 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC H ++E LL+ G ++ ++G +PLH+A+ G IVK LL +GA N
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N TPLH AA E+A LL+ A +AK + T +H AA
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 511
Score = 72.0 bits (175), Expect = 2e-13
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D T LH A GH + + LL G N + G++PLHIA +++ LL GA
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++AV ++G TPLH A+ I LL+ GA+P+ + T +H AA
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478
Score = 71.6 bits (174), Expect = 2e-13
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
+H A H + V LLQ ++D +PLH+AA G + K LL KGA+ N+
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
NG TPLH A KN + +LL+ GA+ DA T +H A+
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
Score = 70.9 bits (172), Expect = 4e-13
Identities = 37/113 (32%), Positives = 63/113 (55%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +L+ ++ ++ T LH GH + + L++ GV V+ G++PLH+A
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ G ++VK LL A VNA + G +PLH AA + +I +LL+ GA+P+
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/106 (40%), Positives = 52/106 (49%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A AGHTE+ ++LLQ VN K +PLH AA G +VK LL A N
Sbjct: 472 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
G TPLH AA + E + LLE A+ T +H AA
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/106 (41%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GH IV+ LLQ G N + +PLH+AA AG E+ K LL A+VNA
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++ TPLH AA + +LLE ANP+ T +H AA
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 544
Score = 68.6 bits (166), Expect = 2e-12
Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A+ +LAT T LH A GH E V LL+ G++PLH+AA G+
Sbjct: 527 ANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + LL + A NA +NG TPLH A N +I +LL G +P + T +H AA
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 643
Query: 148 AKD 150
++
Sbjct: 644 KQN 646
Score = 67.8 bits (164), Expect = 3e-12
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G +E + + + S A T + T LH A G + E LL+ N G
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLH+A +IVK LL +G ++ NG TPLH AA +N+ E+A LL+ G + +
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 134 AKDHYEATAMHRAA 147
A+ T +H AA
Sbjct: 663 AESVQGVTPLHLAA 676
Score = 67.4 bits (163), Expect = 4e-12
Identities = 39/106 (36%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A E+ LLQ G N + G +PLH+AA G E+V LL K A N
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N++G TPLH A + +A +L++ G DA T +H A+
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L + + T + TALH A AG E+V L+ G VN + G++PL++AA
Sbjct: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
E+VK LL GA N ++G TPL A + + L+ G K A+H
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHI 212
Query: 146 AAAKD 150
AA D
Sbjct: 213 AARND 217
Score = 64.3 bits (155), Expect = 4e-11
Identities = 39/109 (35%), Positives = 55/109 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + + + LL G VN G +PLHIA+ G +V+ LL +GAQ+
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 300
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++ TPLH AA I+ +LL+ GA AK + +H AA D
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349
Score = 63.2 bits (152), Expect = 8e-11
Identities = 39/127 (30%), Positives = 59/127 (46%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ S+L A T LH A GH E+V LL N + +G +PLH+
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A G + L+ G V+A + G TPLH A+ ++ LL+ A+ +AK
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 141 TAMHRAA 147
+ +H+AA
Sbjct: 769 SPLHQAA 775
Score = 62.4 bits (150), Expect = 1e-10
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T LLQ + G++PLHIAA + + LL +GA VN
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
QNG TPLH A+ + + +LL+ GA + K E T +H AA
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Score = 62.4 bits (150), Expect = 1e-10
Identities = 37/106 (34%), Positives = 54/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + +IV+ LL G + G++PLHIAA + E+ ++LL G NA
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPLH AA + E+ +LL AN + + T +H A
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 709
Score = 60.8 bits (146), Expect = 4e-10
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 5/92 (5%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+K ++ D T + T LH A G+ ++V+FLLQ VN K G+SPLH AA
Sbjct: 721 IKHGVMVDA-----TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
G +IV LL GA N V+ +G TPL A
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 58.9 bits (141), Expect = 2e-09
Identities = 38/112 (33%), Positives = 53/112 (47%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T Q+ T LH A G+ +V LL G + K +PLH AA G I + LL
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +P+H AA + + +LL+ A D T +H AA
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 379
Score = 50.1 bits (118), Expect = 7e-07
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 30/165 (18%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G+ E ++E + ++ ++ Q T L+ A H E+V+FLL+ G N + G
Sbjct: 119 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
++PL +A G + +V L+ G + + +++
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G TPLH AA +A +LL GA+ + T +H A+ +
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
Score = 48.9 bits (115), Expect = 2e-06
Identities = 37/137 (27%), Positives = 66/137 (48%), Gaps = 5/137 (3%)
Query: 19 LEELKESILADKSLATRTDQ-----DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
L+E KE +++ R+ D+ T+ A +G+ + L+ GV +N + G
Sbjct: 19 LQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNG 78
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ LH+A+ G ++V LL K + + G T LH AA + E+ L+ GAN +
Sbjct: 79 LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138
Query: 134 AKDHYEATAMHRAAAKD 150
A+ T ++ AA ++
Sbjct: 139 AQSQKGFTPLYMAAQEN 155
Score = 35.4 bits (80), Expect = 0.019
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
LH A GHT+IV LL+ G N+ G +PL IA G + L
Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 80.5 bits (197), Expect = 5e-16
Identities = 53/145 (36%), Positives = 75/145 (51%), Gaps = 3/145 (2%)
Query: 5 VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
VSN+ V ++A E+ + +L +K+ +D +T LH A GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
N AG +PLHIAA G E V ALL K A + + G TPLH AA + +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 122 AVMLLEGGANPDAKDHYEATAMHRA 146
A +LLE A+P+A T +H A
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVA 576
Score = 77.4 bits (189), Expect = 4e-15
Identities = 46/118 (38%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG L++ + + + T +Q+ LH A GH ++V LL + + G
Sbjct: 20 ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+ LHIAA AG+DE+V+ L+ GA VNA +Q G TPL+ AA +N E+ LLE GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Score = 76.6 bits (187), Expect = 7e-15
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Query: 26 ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
+L D+ T +D T LH A GH I E LL G P+ K G SP+H+AA
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
+ V+ LL A+++ + + TPLH AA H +A +LL+ GA P+++ T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 145 RAAAKD 150
A K+
Sbjct: 377 IACKKN 382
Score = 75.9 bits (185), Expect = 1e-14
Identities = 42/106 (39%), Positives = 58/106 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC H ++E LL+ G ++ ++G +PLH+A+ G IVK LL +GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N TPLH AA E+A LL+ A +AK + T +H AA
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Score = 72.0 bits (175), Expect = 2e-13
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D T LH A GH + + LL G N + G++PLHIA +++ LL GA
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++AV ++G TPLH A+ I LL+ GA+P+ + T +H AA
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Score = 71.6 bits (174), Expect = 2e-13
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
+H A H + V LLQ ++D +PLH+AA G + K LL KGA+ N+
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
NG TPLH A KN + +LL+ GA+ DA T +H A+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Score = 70.9 bits (172), Expect = 4e-13
Identities = 37/113 (32%), Positives = 63/113 (55%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +L+ ++ ++ T LH GH + + L++ GV V+ G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ G ++VK LL A VNA + G +PLH AA + +I +LL+ GA+P+
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/106 (40%), Positives = 52/106 (49%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A AGHTE+ ++LLQ VN K +PLH AA G +VK LL A N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
G TPLH AA + E + LLE A+ T +H AA
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/106 (41%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GH IV+ LLQ G N + +PLH+AA AG E+ K LL A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++ TPLH AA + +LLE ANP+ T +H AA
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Score = 68.6 bits (166), Expect = 2e-12
Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A+ +LAT T LH A GH E V LL+ G++PLH+AA G+
Sbjct: 494 ANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + LL + A NA +NG TPLH A N +I +LL G +P + T +H AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 148 AKD 150
++
Sbjct: 611 KQN 613
Score = 67.8 bits (164), Expect = 3e-12
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G +E + + + S A T + T LH A G + E LL+ N G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLH+A +IVK LL +G ++ NG TPLH AA +N+ E+A LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 134 AKDHYEATAMHRAA 147
A+ T +H AA
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 67.4 bits (163), Expect = 4e-12
Identities = 39/106 (36%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A E+ LLQ G N + G +PLH+AA G E+V LL K A N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N++G TPLH A + +A +L++ G DA T +H A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L + + T + TALH A AG E+V L+ G VN + G++PL++AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
E+VK LL GA N ++G TPL A + + L+ G K A+H
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHI 179
Query: 146 AAAKD 150
AA D
Sbjct: 180 AARND 184
Score = 64.3 bits (155), Expect = 4e-11
Identities = 39/109 (35%), Positives = 55/109 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + + + LL G VN G +PLHIA+ G +V+ LL +GAQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++ TPLH AA I+ +LL+ GA AK + +H AA D
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Score = 63.2 bits (152), Expect = 8e-11
Identities = 39/127 (30%), Positives = 59/127 (46%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ S+L A T LH A GH E+V LL N + +G +PLH+
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A G + L+ G V+A + G TPLH A+ ++ LL+ A+ +AK
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 141 TAMHRAA 147
+ +H+AA
Sbjct: 736 SPLHQAA 742
Score = 62.4 bits (150), Expect = 1e-10
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T LLQ + G++PLHIAA + + LL +GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
QNG TPLH A+ + + +LL+ GA + K E T +H AA
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Score = 62.4 bits (150), Expect = 1e-10
Identities = 37/106 (34%), Positives = 54/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + +IV+ LL G + G++PLHIAA + E+ ++LL G NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPLH AA + E+ +LL AN + + T +H A
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Score = 60.8 bits (146), Expect = 4e-10
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 5/92 (5%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+K ++ D T + T LH A G+ ++V+FLLQ VN K G+SPLH AA
Sbjct: 688 IKHGVMVDA-----TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
G +IV LL GA N V+ +G TPL A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 58.9 bits (141), Expect = 2e-09
Identities = 38/112 (33%), Positives = 53/112 (47%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T Q+ T LH A G+ +V LL G + K +PLH AA G I + LL
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +P+H AA + + +LL+ A D T +H AA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 50.1 bits (118), Expect = 7e-07
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 30/165 (18%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G+ E ++E + ++ ++ Q T L+ A H E+V+FLL+ G N + G
Sbjct: 86 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
++PL +A G + +V L+ G + + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G TPLH AA +A +LL GA+ + T +H A+ +
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Score = 48.5 bits (114), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
+ D+ T+ A +G+ + L+ GV +N + G + LH+A+ G ++V LL K
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+ + G T LH AA + E+ L+ GAN +A+ T ++ AA ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Score = 35.4 bits (80), Expect = 0.019
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
LH A GHT+IV LL+ G N+ G +PL IA G + L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 80.5 bits (197), Expect = 5e-16
Identities = 53/145 (36%), Positives = 75/145 (51%), Gaps = 3/145 (2%)
Query: 5 VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
VSN+ V ++A E+ + +L +K+ +D +T LH A GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
N AG +PLHIAA G E V ALL K A + + G TPLH AA + +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 122 AVMLLEGGANPDAKDHYEATAMHRA 146
A +LLE A+P+A T +H A
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVA 576
Score = 77.4 bits (189), Expect = 4e-15
Identities = 46/118 (38%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG L++ + + + T +Q+ LH A GH ++V LL + + G
Sbjct: 20 ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+ LHIAA AG+DE+V+ L+ GA VNA +Q G TPL+ AA +N E+ LLE GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Score = 76.6 bits (187), Expect = 7e-15
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Query: 26 ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
+L D+ T +D T LH A GH I E LL G P+ K G SP+H+AA
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
+ V+ LL A+++ + + TPLH AA H +A +LL+ GA P+++ T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 145 RAAAKD 150
A K+
Sbjct: 377 IACKKN 382
Score = 75.9 bits (185), Expect = 1e-14
Identities = 42/106 (39%), Positives = 58/106 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC H ++E LL+ G ++ ++G +PLH+A+ G IVK LL +GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N TPLH AA E+A LL+ A +AK + T +H AA
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Score = 72.0 bits (175), Expect = 2e-13
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D T LH A GH + + LL G N + G++PLHIA +++ LL GA
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++AV ++G TPLH A+ I LL+ GA+P+ + T +H AA
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Score = 71.6 bits (174), Expect = 2e-13
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
+H A H + V LLQ ++D +PLH+AA G + K LL KGA+ N+
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
NG TPLH A KN + +LL+ GA+ DA T +H A+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Score = 70.9 bits (172), Expect = 4e-13
Identities = 37/113 (32%), Positives = 63/113 (55%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +L+ ++ ++ T LH GH + + L++ GV V+ G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ G ++VK LL A VNA + G +PLH AA + +I +LL+ GA+P+
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/106 (40%), Positives = 52/106 (49%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A AGHTE+ ++LLQ VN K +PLH AA G +VK LL A N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
G TPLH AA + E + LLE A+ T +H AA
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/106 (41%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GH IV+ LLQ G N + +PLH+AA AG E+ K LL A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++ TPLH AA + +LLE ANP+ T +H AA
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Score = 68.6 bits (166), Expect = 2e-12
Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A+ +LAT T LH A GH E V LL+ G++PLH+AA G+
Sbjct: 494 ANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + LL + A NA +NG TPLH A N +I +LL G +P + T +H AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 148 AKD 150
++
Sbjct: 611 KQN 613
Score = 67.8 bits (164), Expect = 3e-12
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G +E + + + S A T + T LH A G + E LL+ N G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLH+A +IVK LL +G ++ NG TPLH AA +N+ E+A LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 134 AKDHYEATAMHRAA 147
A+ T +H AA
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 67.4 bits (163), Expect = 4e-12
Identities = 39/106 (36%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A E+ LLQ G N + G +PLH+AA G E+V LL K A N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N++G TPLH A + +A +L++ G DA T +H A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L + + T + TALH A AG E+V L+ G VN + G++PL++AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
E+VK LL GA N ++G TPL A + + L+ G K A+H
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHI 179
Query: 146 AAAKD 150
AA D
Sbjct: 180 AARND 184
Score = 64.3 bits (155), Expect = 4e-11
Identities = 39/109 (35%), Positives = 55/109 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + + + LL G VN G +PLHIA+ G +V+ LL +GAQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++ TPLH AA I+ +LL+ GA AK + +H AA D
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Score = 63.2 bits (152), Expect = 8e-11
Identities = 39/127 (30%), Positives = 59/127 (46%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ S+L A T LH A GH E+V LL N + +G +PLH+
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A G + L+ G V+A + G TPLH A+ ++ LL+ A+ +AK
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 141 TAMHRAA 147
+ +H+AA
Sbjct: 736 SPLHQAA 742
Score = 62.4 bits (150), Expect = 1e-10
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T LLQ + G++PLHIAA + + LL +GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
QNG TPLH A+ + + +LL+ GA + K E T +H AA
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Score = 62.4 bits (150), Expect = 1e-10
Identities = 37/106 (34%), Positives = 54/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + +IV+ LL G + G++PLHIAA + E+ ++LL G NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPLH AA + E+ +LL AN + + T +H A
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Score = 60.8 bits (146), Expect = 4e-10
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 5/92 (5%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+K ++ D T + T LH A G+ ++V+FLLQ VN K G+SPLH AA
Sbjct: 688 IKHGVMVDA-----TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
G +IV LL GA N V+ +G TPL A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 58.9 bits (141), Expect = 2e-09
Identities = 38/112 (33%), Positives = 53/112 (47%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T Q+ T LH A G+ +V LL G + K +PLH AA G I + LL
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +P+H AA + + +LL+ A D T +H AA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 50.1 bits (118), Expect = 7e-07
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 30/165 (18%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G+ E ++E + ++ ++ Q T L+ A H E+V+FLL+ G N + G
Sbjct: 86 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
++PL +A G + +V L+ G + + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G TPLH AA +A +LL GA+ + T +H A+ +
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Score = 48.5 bits (114), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
+ D+ T+ A +G+ + L+ GV +N + G + LH+A+ G ++V LL K
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+ + G T LH AA + E+ L+ GAN +A+ T ++ AA ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Score = 35.4 bits (80), Expect = 0.019
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
LH A GHT+IV LL+ G N+ G +PL IA G + L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 80.5 bits (197), Expect = 5e-16
Identities = 53/145 (36%), Positives = 75/145 (51%), Gaps = 3/145 (2%)
Query: 5 VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
VSN+ V ++A E+ + +L +K+ +D +T LH A GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
N AG +PLHIAA G E V ALL K A + + G TPLH AA + +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 122 AVMLLEGGANPDAKDHYEATAMHRA 146
A +LLE A+P+A T +H A
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVA 576
Score = 77.4 bits (189), Expect = 4e-15
Identities = 46/118 (38%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG L++ + + + T +Q+ LH A GH ++V LL + + G
Sbjct: 20 ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+ LHIAA AG+DE+V+ L+ GA VNA +Q G TPL+ AA +N E+ LLE GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Score = 76.6 bits (187), Expect = 7e-15
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Query: 26 ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
+L D+ T +D T LH A GH I E LL G P+ K G SP+H+AA
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
+ V+ LL A+++ + + TPLH AA H +A +LL+ GA P+++ T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 145 RAAAKD 150
A K+
Sbjct: 377 IACKKN 382
Score = 75.9 bits (185), Expect = 1e-14
Identities = 42/106 (39%), Positives = 58/106 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC H ++E LL+ G ++ ++G +PLH+A+ G IVK LL +GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N TPLH AA E+A LL+ A +AK + T +H AA
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Score = 72.0 bits (175), Expect = 2e-13
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D T LH A GH + + LL G N + G++PLHIA +++ LL GA
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++AV ++G TPLH A+ I LL+ GA+P+ + T +H AA
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Score = 71.6 bits (174), Expect = 2e-13
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
+H A H + V LLQ ++D +PLH+AA G + K LL KGA+ N+
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
NG TPLH A KN + +LL+ GA+ DA T +H A+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Score = 70.9 bits (172), Expect = 4e-13
Identities = 37/113 (32%), Positives = 63/113 (55%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +L+ ++ ++ T LH GH + + L++ GV V+ G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ G ++VK LL A VNA + G +PLH AA + +I +LL+ GA+P+
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/106 (40%), Positives = 52/106 (49%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A AGHTE+ ++LLQ VN K +PLH AA G +VK LL A N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
G TPLH AA + E + LLE A+ T +H AA
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/106 (41%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GH IV+ LLQ G N + +PLH+AA AG E+ K LL A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++ TPLH AA + +LLE ANP+ T +H AA
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Score = 68.6 bits (166), Expect = 2e-12
Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A+ +LAT T LH A GH E V LL+ G++PLH+AA G+
Sbjct: 494 ANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + LL + A NA +NG TPLH A N +I +LL G +P + T +H AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 148 AKD 150
++
Sbjct: 611 KQN 613
Score = 67.8 bits (164), Expect = 3e-12
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G +E + + + S A T + T LH A G + E LL+ N G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLH+A +IVK LL +G ++ NG TPLH AA +N+ E+A LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 134 AKDHYEATAMHRAA 147
A+ T +H AA
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 67.4 bits (163), Expect = 4e-12
Identities = 39/106 (36%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A E+ LLQ G N + G +PLH+AA G E+V LL K A N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N++G TPLH A + +A +L++ G DA T +H A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L + + T + TALH A AG E+V L+ G VN + G++PL++AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
E+VK LL GA N ++G TPL A + + L+ G K A+H
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHI 179
Query: 146 AAAKD 150
AA D
Sbjct: 180 AARND 184
Score = 64.3 bits (155), Expect = 4e-11
Identities = 39/109 (35%), Positives = 55/109 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + + + LL G VN G +PLHIA+ G +V+ LL +GAQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++ TPLH AA I+ +LL+ GA AK + +H AA D
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Score = 63.2 bits (152), Expect = 8e-11
Identities = 39/127 (30%), Positives = 59/127 (46%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ S+L A T LH A GH E+V LL N + +G +PLH+
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A G + L+ G V+A + G TPLH A+ ++ LL+ A+ +AK
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 141 TAMHRAA 147
+ +H+AA
Sbjct: 736 SPLHQAA 742
Score = 62.4 bits (150), Expect = 1e-10
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T LLQ + G++PLHIAA + + LL +GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
QNG TPLH A+ + + +LL+ GA + K E T +H AA
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Score = 62.4 bits (150), Expect = 1e-10
Identities = 37/106 (34%), Positives = 54/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + +IV+ LL G + G++PLHIAA + E+ ++LL G NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPLH AA + E+ +LL AN + + T +H A
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Score = 60.8 bits (146), Expect = 4e-10
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 5/92 (5%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+K ++ D T + T LH A G+ ++V+FLLQ VN K G+SPLH AA
Sbjct: 688 IKHGVMVDA-----TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
G +IV LL GA N V+ +G TPL A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 58.9 bits (141), Expect = 2e-09
Identities = 38/112 (33%), Positives = 53/112 (47%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T Q+ T LH A G+ +V LL G + K +PLH AA G I + LL
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +P+H AA + + +LL+ A D T +H AA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 50.1 bits (118), Expect = 7e-07
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 30/165 (18%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G+ E ++E + ++ ++ Q T L+ A H E+V+FLL+ G N + G
Sbjct: 86 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
++PL +A G + +V L+ G + + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G TPLH AA +A +LL GA+ + T +H A+ +
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Score = 48.5 bits (114), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
+ D+ T+ A +G+ + L+ GV +N + G + LH+A+ G ++V LL K
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+ + G T LH AA + E+ L+ GAN +A+ T ++ AA ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Score = 35.4 bits (80), Expect = 0.019
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
LH A GHT+IV LL+ G N+ G +PL IA G + L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 80.5 bits (197), Expect = 5e-16
Identities = 53/145 (36%), Positives = 75/145 (51%), Gaps = 3/145 (2%)
Query: 5 VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
VSN+ V ++A E+ + +L +K+ +D +T LH A GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
N AG +PLHIAA G E V ALL K A + + G TPLH AA + +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 122 AVMLLEGGANPDAKDHYEATAMHRA 146
A +LLE A+P+A T +H A
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVA 576
Score = 77.4 bits (189), Expect = 4e-15
Identities = 46/118 (38%), Positives = 66/118 (55%), Gaps = 1/118 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG L++ + + + T +Q+ LH A GH ++V LL + + G
Sbjct: 20 ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+ LHIAA AG+DE+V+ L+ GA VNA +Q G TPL+ AA +N E+ LLE GAN
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Score = 76.6 bits (187), Expect = 7e-15
Identities = 44/126 (34%), Positives = 65/126 (51%), Gaps = 1/126 (0%)
Query: 26 ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
+L D+ T +D T LH A GH I E LL G P+ K G SP+H+AA
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
+ V+ LL A+++ + + TPLH AA H +A +LL+ GA P+++ T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 145 RAAAKD 150
A K+
Sbjct: 377 IACKKN 382
Score = 75.9 bits (185), Expect = 1e-14
Identities = 42/106 (39%), Positives = 58/106 (54%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH AC H ++E LL+ G ++ ++G +PLH+A+ G IVK LL +GA N
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N TPLH AA E+A LL+ A +AK + T +H AA
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478
Score = 72.0 bits (175), Expect = 2e-13
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
D T LH A GH + + LL G N + G++PLHIA +++ LL GA
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++AV ++G TPLH A+ I LL+ GA+P+ + T +H AA
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Score = 71.6 bits (174), Expect = 2e-13
Identities = 39/104 (37%), Positives = 54/104 (51%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
+H A H + V LLQ ++D +PLH+AA G + K LL KGA+ N+
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
NG TPLH A KN + +LL+ GA+ DA T +H A+
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Score = 70.9 bits (172), Expect = 4e-13
Identities = 37/113 (32%), Positives = 63/113 (55%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ +L+ ++ ++ T LH GH + + L++ GV V+ G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ G ++VK LL A VNA + G +PLH AA + +I +LL+ GA+P+
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Score = 70.1 bits (170), Expect = 7e-13
Identities = 43/106 (40%), Positives = 52/106 (49%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A AGHTE+ ++LLQ VN K +PLH AA G +VK LL A N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
G TPLH AA + E + LLE A+ T +H AA
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 69.3 bits (168), Expect = 1e-12
Identities = 44/106 (41%), Positives = 56/106 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A GH IV+ LLQ G N + +PLH+AA AG E+ K LL A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
++ TPLH AA + +LLE ANP+ T +H AA
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Score = 68.6 bits (166), Expect = 2e-12
Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 3/123 (2%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
A+ +LAT T LH A GH E V LL+ G++PLH+AA G+
Sbjct: 494 ANPNLATTA---GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ + LL + A NA +NG TPLH A N +I +LL G +P + T +H AA
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAA 610
Query: 148 AKD 150
++
Sbjct: 611 KQN 613
Score = 67.8 bits (164), Expect = 3e-12
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 1/134 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G +E + + + S A T + T LH A G + E LL+ N G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+PLH+A +IVK LL +G ++ NG TPLH AA +N+ E+A LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 134 AKDHYEATAMHRAA 147
A+ T +H AA
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 67.4 bits (163), Expect = 4e-12
Identities = 39/106 (36%), Positives = 53/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A E+ LLQ G N + G +PLH+AA G E+V LL K A N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
N++G TPLH A + +A +L++ G DA T +H A+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 4/125 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L + + T + TALH A AG E+V L+ G VN + G++PL++AA
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
E+VK LL GA N ++G TPL A + + L+ G K A+H
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHI 179
Query: 146 AAAKD 150
AA D
Sbjct: 180 AARND 184
Score = 64.3 bits (155), Expect = 4e-11
Identities = 39/109 (35%), Positives = 55/109 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + + + LL G VN G +PLHIA+ G +V+ LL +GAQ+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIET 267
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
++ TPLH AA I+ +LL+ GA AK + +H AA D
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Score = 63.2 bits (152), Expect = 8e-11
Identities = 39/127 (30%), Positives = 59/127 (46%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ S+L A T LH A GH E+V LL N + +G +PLH+
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
A G + L+ G V+A + G TPLH A+ ++ LL+ A+ +AK
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 141 TAMHRAA 147
+ +H+AA
Sbjct: 736 SPLHQAA 742
Score = 62.4 bits (150), Expect = 1e-10
Identities = 39/105 (37%), Positives = 52/105 (49%)
Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
ALH A T LLQ + G++PLHIAA + + LL +GA VN
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
QNG TPLH A+ + + +LL+ GA + K E T +H AA
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Score = 62.4 bits (150), Expect = 1e-10
Identities = 37/106 (34%), Positives = 54/106 (50%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A + +IV+ LL G + G++PLHIAA + E+ ++LL G NA
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
+ G TPLH AA + E+ +LL AN + + T +H A
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Score = 60.8 bits (146), Expect = 4e-10
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 5/92 (5%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+K ++ D T + T LH A G+ ++V+FLLQ VN K G+SPLH AA
Sbjct: 688 IKHGVMVDA-----TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
G +IV LL GA N V+ +G TPL A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 58.9 bits (141), Expect = 2e-09
Identities = 38/112 (33%), Positives = 53/112 (47%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
T Q+ T LH A G+ +V LL G + K +PLH AA G I + LL
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA + A +NG +P+H AA + + +LL+ A D T +H AA
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 50.1 bits (118), Expect = 7e-07
Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 30/165 (18%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A +G+ E ++E + ++ ++ Q T L+ A H E+V+FLL+ G N + G
Sbjct: 86 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
++PL +A G + +V L+ G + + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
G TPLH AA +A +LL GA+ + T +H A+ +
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Score = 48.5 bits (114), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
+ D+ T+ A +G+ + L+ GV +N + G + LH+A+ G ++V LL K
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
+ + G T LH AA + E+ L+ GAN +A+ T ++ AA ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Score = 35.4 bits (80), Expect = 0.019
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
LH A GHT+IV LL+ G N+ G +PL IA G + L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 80.1 bits (196), Expect = 7e-16
Identities = 47/134 (35%), Positives = 74/134 (55%), Gaps = 3/134 (2%)
Query: 15 YSGKLEELKESILADKSLATRT-DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
+SG LE + ++L +K + D+ R LHWA GH E+++ L+ G + KD G
Sbjct: 149 HSGHLETV--NLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ LH AA++G+ E+VK LL GA+++ N G T LH A + +A+ L+ GAN +
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 134 AKDHYEATAMHRAA 147
+ T +H AA
Sbjct: 267 QPNDKGFTPLHVAA 280
Score = 73.2 bits (178), Expect = 8e-14
Identities = 52/173 (30%), Positives = 72/173 (41%), Gaps = 28/173 (16%)
Query: 4 CVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG 63
C L+ YS E +L+ D RT LH A S G+ E + LL G
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
Query: 64 VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIA- 122
+ +D G +PLH AA+ G + L+ GA VN + GC+PLHYAA+ + + A
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
Query: 123 ---------------------------VMLLEGGANPDAKDHYEATAMHRAAA 148
LL+ GA+P +D TA+H AAA
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559
Score = 71.6 bits (174), Expect = 2e-13
Identities = 45/135 (33%), Positives = 71/135 (52%), Gaps = 2/135 (1%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A+ G LE LK + L + D+ LH A ++G E+V++LL++G +++ + G
Sbjct: 181 AFLGHLEVLKLLVARGADLGCK-DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFG 239
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAA-SKNRHEIAVMLLEGGANP 132
+ LHIA G+D + L+ GA VN N G TPLH AA S N +L+ GA+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 133 DAKDHYEATAMHRAA 147
+ + + +H AA
Sbjct: 300 NYQSKEGKSPLHMAA 314
Score = 71.2 bits (173), Expect = 3e-13
Identities = 44/135 (32%), Positives = 68/135 (50%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
++A + + + E++ S D+ R+ALH A +GH E V LL G +N D
Sbjct: 112 HVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
PLH AA G E++K L+ +GA + ++ G LH AA+ + E+ LL GA
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
Query: 132 PDAKDHYEATAMHRA 146
D + + TA+H A
Sbjct: 232 IDEPNAFGNTALHIA 246
Score = 69.3 bits (168), Expect = 1e-12
Identities = 45/132 (34%), Positives = 70/132 (53%), Gaps = 1/132 (0%)
Query: 15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
+S +EE++ S+L+ K DQ+ RT LH A G I++ LL G VN KD
Sbjct: 17 FSRDVEEVR-SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL 75
Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
+PLH AA++ ++++ LL A VNA ++ TPLH AA+ + A L ++ +
Sbjct: 76 TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
Query: 135 KDHYEATAMHRA 146
D +A+H A
Sbjct: 136 ADRSGRSALHHA 147
Score = 69.3 bits (168), Expect = 1e-12
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 2/135 (1%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A SG++E +K + + + TALH AC G + L+ G VN +D G
Sbjct: 214 AASGQIEVVKYLLRMGAEI-DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 74 WSPLHIAASAGRDEI-VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
++PLH+AA + + ++ L+ GA VN ++ G +PLH AA R + +L++ G+
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332
Query: 133 DAKDHYEATAMHRAA 147
D D + T +H AA
Sbjct: 333 DCADKFGNTPLHVAA 347
Score = 67.4 bits (163), Expect = 4e-12
Identities = 37/95 (38%), Positives = 52/95 (54%)
Query: 57 EFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
E +L G +N D+ G + LH AAS G E + LL GA + ++ G TPLHYAA+
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 117 NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKDT 151
++ AV L+ GA + D + +H AAA DT
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501
Score = 62.0 bits (149), Expect = 2e-10
Identities = 44/135 (32%), Positives = 66/135 (48%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A + + E++ +LA + D+ +T LH A + T+ E L L +N D +G
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
S LH A +G E V LL KGA +N ++ PLH+AA E+ +L+ GA+
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200
Query: 134 AKDHYEATAMHRAAA 148
KD +H AAA
Sbjct: 201 CKDRKGYGLLHTAAA 215
Score = 60.5 bits (145), Expect = 5e-10
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 3/135 (2%)
Query: 15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
++ L L ++ L+ L D + +HWA GH + +E LL+ P + + +
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS-PFSYLEGNPF 824
Query: 75 SPLHIAASAGRDEIVKALLGK-GAQ-VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
+PLH A +D + LLG GA+ VN+ + G TPLH AA + MLL+ A
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 133 DAKDHYEATAMHRAA 147
+A DH TA+ AA
Sbjct: 885 NATDHTGRTALMTAA 899
Score = 58.2 bits (139), Expect = 3e-09
Identities = 42/118 (35%), Positives = 64/118 (54%), Gaps = 6/118 (5%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL----QLGVPVNDK 69
A +G+ ++ + K+ T D++ TALH ACS GH + +L LG+ +N
Sbjct: 899 AENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INAT 957
Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP-LHYAASKNRHEIAVMLL 126
+ A PLHIAA G +V+ALL GA V AV++ G TP L A +K+ + ++L
Sbjct: 958 NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
Score = 54.7 bits (130), Expect = 3e-08
Identities = 36/95 (37%), Positives = 49/95 (51%)
Query: 54 EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
E V LL +N D +PLH AA G I++ LL GA VNA + TPLH A
Sbjct: 22 EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81
Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
A+ ++ +LL A+ +A+D T +H AAA
Sbjct: 82 AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAA 116
Score = 54.7 bits (130), Expect = 3e-08
Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 7/137 (5%)
Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD----AGWS 75
E+ ++L + D RT +H A + GHT ++ LLQ + + D +G+S
Sbjct: 734 EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793
Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE--GGANPD 133
P+H A+ G ++ ++ LL + + + + N TPLH A N+ MLL G +
Sbjct: 794 PMHWASYTGHEDCLELLL-EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVN 852
Query: 134 AKDHYEATAMHRAAAKD 150
++D T +H AA D
Sbjct: 853 SRDAKGRTPLHAAAFAD 869
Score = 50.4 bits (119), Expect = 6e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 1/106 (0%)
Query: 42 TALHWAC-SAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
T LH A S +E L+ G VN + G SPLH+AA GR + L+ G++++
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333
Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
++ G TPLH AA + L+ GA+ + ++ +H A
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379
Score = 50.1 bits (118), Expect = 7e-07
Identities = 36/110 (32%), Positives = 53/110 (48%), Gaps = 3/110 (2%)
Query: 42 TALHWACSAGHTEIVEFLLQLG--VPVNDKDDA-GWSPLHIAASAGRDEIVKALLGKGAQ 98
T LH A ++GHT+ + L+ G + D DA G +PL +A G + V LL KG+
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+A + G T LH A + LL+ A +D T +H A+A
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763
Score = 49.3 bits (116), Expect = 1e-06
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 1/91 (1%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D RT LH A A + + LLQ VN D G + L AA G+ V+ LL +G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Query: 97 -AQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126
A + +++N T LH A SK + A+M+L
Sbjct: 915 KADLTVLDENKNTALHLACSKGHEKCALMIL 945
Score = 47.0 bits (110), Expect = 6e-06
Identities = 37/115 (32%), Positives = 50/115 (43%), Gaps = 4/115 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDAGWSPLHIAASAG 84
+L ++ TD RTAL A G T VEFLL G + D+ + LH+A S G
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
Query: 85 RDEIVKALLGKGAQ---VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
++ +L + +NA N PLH AA + LL GA A D
Sbjct: 937 HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991
Score = 45.4 bits (106), Expect = 2e-05
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L S A D RTALH G + + LL V +D G +P+H+A++ G
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
Query: 86 DEIVKALLGKGAQVN----AVNQNGCTPLHYAASKNRHEIAVMLLE 127
+++ LL + V+ +G +P+H+A+ + +LLE
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Score = 44.7 bits (104), Expect = 3e-05
Identities = 37/124 (29%), Positives = 59/124 (47%), Gaps = 6/124 (4%)
Query: 28 ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGR 85
AD SL D+ TA+H+A + G+ + +E LL++ + ++ SPLH+AA G
Sbjct: 541 ADPSLR---DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA-TAMH 144
E +K L ++ + G T L A + E +L GA+ K+ T +H
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLH 657
Query: 145 RAAA 148
AAA
Sbjct: 658 AAAA 661
Score = 44.3 bits (103), Expect = 4e-05
Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 37/141 (26%)
Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAG------------------------------ 73
LH A GH E ++ L + V ++ +D G
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 74 ----WSPLHIAASAGRDEIVKALLGKGAQ---VNAVNQNGCTPLHYAASKNRHEIAVMLL 126
W+PLH AA++G + + L+ G + + ++ G TPL A + +LL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 127 EGGANPDAKDHYEATAMHRAA 147
E G+ DA D TA+HR A
Sbjct: 709 EKGSTADAADLRGRTALHRGA 729
Score = 43.9 bits (102), Expect = 5e-05
Identities = 30/100 (30%), Positives = 45/100 (45%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D +T L A GH + V LL+ G + D G + LH A G ++ + ALL
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
A V + G TP+H A++ + LL+ + D D
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLD 784
Score = 41.6 bits (96), Expect = 3e-04
Identities = 25/92 (27%), Positives = 41/92 (44%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
++ ++ LH A G + L+Q G ++ D G +PLH+AA G + ++ L+ GA
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129
+ PLH A + LL G
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 38.5 bits (88), Expect = 0.002
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 2/96 (2%)
Query: 56 VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV--NAVNQNGCTPLHYA 113
+EFLL G + +D G++ +H AA+ G + ++ LL + + +PLH A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
A E L E N D +DH TA+ A +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATER 628
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 79.3 bits (194), Expect = 1e-15
Identities = 53/147 (36%), Positives = 75/147 (51%), Gaps = 27/147 (18%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
+++ T+ D +ALH AC + E+V FL++ G VN D+ GW+PLH+AAS G +I
Sbjct: 91 RAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIA 150
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAAS--------------------KNRHEIAVML---- 125
+ LL GA + AVN +G PL A S R E ++L
Sbjct: 151 RYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTR 210
Query: 126 --LEGGANPDAK-DHYEATAMHRAAAK 149
L GGA P+A+ A+A+H AAAK
Sbjct: 211 CWLNGGAMPEARHPRTGASALHVAAAK 237
Score = 50.4 bits (119), Expect = 6e-07
Identities = 38/154 (24%), Positives = 65/154 (42%), Gaps = 27/154 (17%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ ++ + + D + T LH A S G+ +I +LL G + + G PL +A
Sbjct: 115 EVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLA 174
Query: 81 ASAGRDEIVKA-LLGKGAQVNAVN--------------------------QNGCTPLHYA 113
S + ++KA + +G V A + G + LH A
Sbjct: 175 ESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVA 234
Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A+K E+ +LL+ G +P+ +D T +H AA
Sbjct: 235 AAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAA 268
Score = 47.8 bits (112), Expect = 4e-06
Identities = 25/79 (31%), Positives = 40/79 (50%)
Query: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
R + +ALH A + G+ E++ LLQ G +D GW+PLH AA G ++ + L
Sbjct: 222 RHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAE 281
Query: 95 KGAQVNAVNQNGCTPLHYA 113
G ++++ G P A
Sbjct: 282 HGGGMDSLTHAGQRPCDLA 300
Score = 40.0 bits (92), Expect = 8e-04
Identities = 23/65 (35%), Positives = 33/65 (50%)
Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
G S LH+AA+ G E+++ LL G + +G TPLH AA + +L E G
Sbjct: 227 GASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGM 286
Query: 133 DAKDH 137
D+ H
Sbjct: 287 DSLTH 291
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 79.3 bits (194), Expect = 1e-15
Identities = 43/116 (37%), Positives = 65/116 (56%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ E +L + + D+ TA+HWAC GH E+V+ L G N +D +PLH+A
Sbjct: 195 EILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVA 254
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
G+ EIV+ L G ++NA ++ G T LH A NR++I +LL GA+ K+
Sbjct: 255 VRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 310
Score = 75.1 bits (183), Expect = 2e-14
Identities = 51/133 (38%), Positives = 66/133 (49%), Gaps = 1/133 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A GK++ + E LAD A DQ RTALH A GH EI+E LL G V+ +D
Sbjct: 156 AVEGKMKVI-EKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ +H A G E+VK L GA N ++ TPLH A + EI L G +
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
Query: 134 AKDHYEATAMHRA 146
A+D TA+H A
Sbjct: 275 ARDREGDTALHDA 287
Score = 50.1 bits (118), Expect = 7e-07
Identities = 29/68 (42%), Positives = 36/68 (52%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A G EIVE L LG+ +N +D G + LH A R +I+K LL GA +
Sbjct: 249 TPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMT 308
Query: 102 VNQNGCTP 109
N G TP
Sbjct: 309 KNLAGKTP 316
Score = 47.4 bits (111), Expect = 5e-06
Identities = 29/100 (29%), Positives = 49/100 (49%)
Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106
A G +++E L G + D + LH A+ G EI++ LL GA V+ ++
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
CT +H+A E+ +L GA+ + +D +T +H A
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVA 254
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 77.8 bits (190), Expect = 3e-15
Identities = 40/111 (36%), Positives = 64/111 (57%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + RT L A + G+ E+V LL G+ N +DDAGW+PLH+AA G I +AL+ +G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A+ N ++ +G P A+ + ++ +LLE +N D + + A+ AA
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAA 921
Score = 76.6 bits (187), Expect = 7e-15
Identities = 49/137 (35%), Positives = 75/137 (54%), Gaps = 5/137 (3%)
Query: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
G E++ ++L + + D + RTAL A GH EIVE LL G VN +D G +
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTA 713
Query: 77 LHIA-----ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
L +A AS G +V L+ +GA+V+ +++G TPL AA + ++ +LLEGGA+
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
Query: 132 PDAKDHYEATAMHRAAA 148
D D+ T + AA+
Sbjct: 774 VDHTDNNGRTPLLAAAS 790
Score = 72.8 bits (177), Expect = 1e-13
Identities = 49/146 (33%), Positives = 70/146 (47%), Gaps = 3/146 (2%)
Query: 4 CVSN--LMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
C SN ++ N AYSG L+ + + L D T L A GHT++V L+
Sbjct: 541 CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIG 599
Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
G +N D GW+ L AA G E+V ALL G +V+ + + T L AA +I
Sbjct: 600 CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDI 659
Query: 122 AVMLLEGGANPDAKDHYEATAMHRAA 147
+ LL+ GA + D+ TA+ AA
Sbjct: 660 VLNLLQHGAEVNKADNEGRTALIAAA 685
Score = 72.8 bits (177), Expect = 1e-13
Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 1/129 (0%)
Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
+ E L + + +D + RTALH +C GH E+V+ L+ VN D+ S L AA
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
G ++V+ L+ GA V+ G T L AA + ++ +LLE GA+P+ D + T
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
Query: 142 AMHRAAAKD 150
AM R AAK+
Sbjct: 1081 AM-RVAAKN 1088
Score = 68.9 bits (167), Expect = 2e-12
Identities = 47/112 (41%), Positives = 58/112 (51%)
Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
TDQD TAL A GHTE+V LL GV V+ D + L AA G ++IV LL
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666
Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
GA+VN + G T L AA EI LL+ GA + +D TA+ AA
Sbjct: 667 GAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Score = 67.8 bits (164), Expect = 3e-12
Identities = 42/124 (33%), Positives = 66/124 (53%), Gaps = 1/124 (0%)
Query: 25 SILADKSLAT-RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
S+L D+ D+D T L A GH ++V+ LL+ G V+ D+ G +PL AAS
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASM 791
Query: 84 GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
G +V LL GA V++++ G T L A+++ E+ LL+ G + + +D T +
Sbjct: 792 GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851
Query: 144 HRAA 147
H AA
Sbjct: 852 HMAA 855
Score = 67.4 bits (163), Expect = 4e-12
Identities = 50/141 (35%), Positives = 67/141 (47%), Gaps = 6/141 (4%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWAC-----SAGHTEIVEFLLQLGVPVND 68
AY G E+ E +L + D D RTAL A S GH +V L+ G V+
Sbjct: 685 AYMGH-REIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
D G +PL +AA G ++V LL GA V+ + NG TPL AAS + LL
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
Query: 129 GANPDAKDHYEATAMHRAAAK 149
GA D+ D T + A+A+
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQ 824
Score = 67.0 bits (162), Expect = 6e-12
Identities = 41/137 (29%), Positives = 67/137 (48%)
Query: 11 CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70
C + + + E+ ++L + + + D + RT L A +G ++V L+ G + +D
Sbjct: 516 CIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIED 575
Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
G +PL +AA G ++V L+G GA +N +Q+G T L AA E+ LL G
Sbjct: 576 AHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
Query: 131 NPDAKDHYEATAMHRAA 147
D D TA+ AA
Sbjct: 636 KVDCADADSRTALRAAA 652
Score = 66.6 bits (161), Expect = 8e-12
Identities = 43/124 (34%), Positives = 63/124 (50%), Gaps = 1/124 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
AY G ++ + + +L + TD + RT L A S GH +V LL G V+ D G
Sbjct: 756 AYEGHVDVV-DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
+ L IA++ G E+V+ LL +G N + G TPLH AA + I L+E GA +
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 134 AKDH 137
D+
Sbjct: 875 EIDN 878
Score = 61.6 bits (148), Expect = 2e-10
Identities = 37/121 (30%), Positives = 59/121 (48%)
Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
E+++ + D D R A GH + V+ LL+ ++ + G + L +AA
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
Query: 84 GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
G +IV+ L GA VN + +G L+ A +N+ +A LE GAN +A D TA+
Sbjct: 924 GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTAL 983
Query: 144 H 144
H
Sbjct: 984 H 984
Score = 60.1 bits (144), Expect = 7e-10
Identities = 40/122 (32%), Positives = 60/122 (49%)
Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
+L +KS + D R AL A GH +IVE L G VN KD G L+I A +
Sbjct: 899 LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
+ + L GA V A + G T LH + + E+ +L+ A+ +A D+ + +A+
Sbjct: 959 LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
Query: 146 AA 147
AA
Sbjct: 1019 AA 1020
Score = 57.4 bits (137), Expect = 5e-09
Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
E+ + ++A + D + R+AL A GH ++V+ L++ G V+ + G + L IA
Sbjct: 993 EMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
A G ++V+ LL GA N +Q G T + AA KN H + LLE
Sbjct: 1053 AQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAA-KNGHSQIIKLLE 1098
Score = 49.3 bits (116), Expect = 1e-06
Identities = 33/111 (29%), Positives = 52/111 (46%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D D R L+ + E+ L+ G V D G + LH++ G E+V+ L+
Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
A VNA + + L AA + ++ +L+E GA D + ATA+ AA
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAA 1053
Score = 47.0 bits (110), Expect = 6e-06
Identities = 35/118 (29%), Positives = 56/118 (47%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K+ A +D RT+ + + + LL G VN D G + L AA +G ++V
Sbjct: 502 KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
L+ +GA + + +G TPL AA + ++ L+ GAN + D TA+ AA
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAA 619
Score = 45.4 bits (106), Expect = 2e-05
Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 4/79 (5%)
Query: 31 SLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVK 90
++ T TAL A GH ++V+ LL+ G N D G + + +AA G +I+K
Sbjct: 1036 AVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK 1095
Query: 91 ALLGKGAQVNAVNQNGCTP 109
L GA + NGC+P
Sbjct: 1096 LLEKYGAS----SLNGCSP 1110
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 77.4 bits (189), Expect = 4e-15
Identities = 48/126 (38%), Positives = 69/126 (54%), Gaps = 2/126 (1%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
EL S+L + + TALH A AGH E + LLQ G VN +D ++PLHIA
Sbjct: 115 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD--AKDHY 138
A G +++ + LL GA VN + G PLH A++K IA +L+E G+ D A+D+
Sbjct: 175 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 234
Query: 139 EATAMH 144
+ +H
Sbjct: 235 DHVPLH 240
Score = 60.5 bits (145), Expect = 5e-10
Identities = 37/109 (33%), Positives = 53/109 (48%), Gaps = 4/109 (3%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG--AQV 99
T LH A GH ++ LL+ G VN + G PLH+A++ G I K L+ +G A V
Sbjct: 169 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 228
Query: 100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGG--ANPDAKDHYEATAMHRA 146
NA + PLH+ + H+I LL+ P + Y T +H A
Sbjct: 229 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 277
Score = 60.1 bits (144), Expect = 7e-10
Identities = 47/149 (31%), Positives = 70/149 (46%), Gaps = 4/149 (2%)
Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLA-TRTDQDSRTALHWACSAGHTEIVEFLL 60
E +S L +C + GK ++ +L K L +R ++ TALH A + E++ LL
Sbjct: 65 ENGLSLLHLCCIC-GGKKSHIRTLML--KGLRPSRLTRNGFTALHLAVYKDNAELITSLL 121
Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
G + G + LHIA AG E LL GA VN + TPLH AA +
Sbjct: 122 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149
+ +LL+ GA+ + +H A+AK
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAK 210
Score = 50.4 bits (119), Expect = 6e-07
Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 6/109 (5%)
Query: 44 LHWACSAGHTEIVEFLLQLG--VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV-- 99
LH A + G I + L++ G VN +D+ PLH + G +IVK LL +V
Sbjct: 204 LHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQP 263
Query: 100 NAVNQNGCTPLHYAASKNRHEIA--VMLLEGGANPDAKDHYEATAMHRA 146
+ VN G TPLH A + E+A ++ + G + ++ + TA H A
Sbjct: 264 HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 312
Score = 36.2 bits (82), Expect = 0.011
Identities = 20/59 (33%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQ--LGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93
D + LH+ GH +IV++LLQ L V + + G +PLH+A G+ E+ K ++
Sbjct: 232 DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 290
Score = 33.9 bits (76), Expect = 0.054
Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 42 TALHWACSAGHTEIVEFLLQL-GVPVNDKDDA-GWSPLHIAASAGRD-EIVKALLGKGA- 97
T LH AC G E+ + ++Q+ G K++ + H A + G+ ++VK LL +
Sbjct: 272 TPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 331
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+N ++G T LH A + LL+ GA+
Sbjct: 332 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 365
Score = 33.1 bits (74), Expect = 0.092
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVN 67
+D T LH AC GH +V+FLL G +N
Sbjct: 338 RDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 77.4 bits (189), Expect = 4e-15
Identities = 48/126 (38%), Positives = 69/126 (54%), Gaps = 2/126 (1%)
Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
EL S+L + + TALH A AGH E + LLQ G VN +D ++PLHIA
Sbjct: 216 ELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD--AKDHY 138
A G +++ + LL GA VN + G PLH A++K IA +L+E G+ D A+D+
Sbjct: 276 AYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE 335
Query: 139 EATAMH 144
+ +H
Sbjct: 336 DHVPLH 341
Score = 60.5 bits (145), Expect = 5e-10
Identities = 37/109 (33%), Positives = 53/109 (48%), Gaps = 4/109 (3%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG--AQV 99
T LH A GH ++ LL+ G VN + G PLH+A++ G I K L+ +G A V
Sbjct: 270 TPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADV 329
Query: 100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGG--ANPDAKDHYEATAMHRA 146
NA + PLH+ + H+I LL+ P + Y T +H A
Sbjct: 330 NAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLA 378
Score = 60.1 bits (144), Expect = 7e-10
Identities = 47/149 (31%), Positives = 70/149 (46%), Gaps = 4/149 (2%)
Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLA-TRTDQDSRTALHWACSAGHTEIVEFLL 60
E +S L +C + GK ++ +L K L +R ++ TALH A + E++ LL
Sbjct: 166 ENGLSLLHLCCIC-GGKKSHIRTLML--KGLRPSRLTRNGFTALHLAVYKDNAELITSLL 222
Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
G + G + LHIA AG E LL GA VN + TPLH AA +
Sbjct: 223 HSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQ 282
Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149
+ +LL+ GA+ + +H A+AK
Sbjct: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAK 311
Score = 50.4 bits (119), Expect = 6e-07
Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 6/109 (5%)
Query: 44 LHWACSAGHTEIVEFLLQLG--VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV-- 99
LH A + G I + L++ G VN +D+ PLH + G +IVK LL +V
Sbjct: 305 LHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQP 364
Query: 100 NAVNQNGCTPLHYAASKNRHEIA--VMLLEGGANPDAKDHYEATAMHRA 146
+ VN G TPLH A + E+A ++ + G + ++ + TA H A
Sbjct: 365 HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSA 413
Score = 36.2 bits (82), Expect = 0.011
Identities = 20/59 (33%), Positives = 33/59 (55%), Gaps = 2/59 (3%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQ--LGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93
D + LH+ GH +IV++LLQ L V + + G +PLH+A G+ E+ K ++
Sbjct: 333 DNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEII 391
Score = 33.9 bits (76), Expect = 0.054
Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 42 TALHWACSAGHTEIVEFLLQL-GVPVNDKDDA-GWSPLHIAASAGRD-EIVKALLGKGA- 97
T LH AC G E+ + ++Q+ G K++ + H A + G+ ++VK LL +
Sbjct: 373 TPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVI 432
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
+N ++G T LH A + LL+ GA+
Sbjct: 433 NINHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD 466
Score = 33.1 bits (74), Expect = 0.092
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVN 67
+D T LH AC GH +V+FLL G +N
Sbjct: 439 RDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 77.0 bits (188), Expect = 6e-15
Identities = 43/111 (38%), Positives = 58/111 (52%), Gaps = 1/111 (0%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K + ++ T LH A G + V+ L+ LG VN KD AGW+PLH A + G ++
Sbjct: 152 KDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVA 211
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP-DAKDHYE 139
K L+ GA VN + TPLH +AS +I +LL G NP A H E
Sbjct: 212 KILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGE 262
Score = 55.1 bits (131), Expect = 2e-08
Identities = 29/83 (34%), Positives = 50/83 (60%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
VN +++ G +PLH+AA G + VK L+ GA VN + G TPLH A + +++A +L
Sbjct: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
Query: 126 LEGGANPDAKDHYEATAMHRAAA 148
+ GA+ + + + T +H +A+
Sbjct: 215 IAAGADVNTQGLDDDTPLHDSAS 237
Score = 52.0 bits (123), Expect = 2e-07
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G ++++KE I ++ + D T LH AC+ G+ ++ + L+ G VN +
Sbjct: 170 AIRGDVKQVKELISLGANVNVK-DFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD 228
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
+PLH +AS+G +IVK LL G N++G P+ A ++
Sbjct: 229 DTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETE 271
Score = 33.5 bits (75), Expect = 0.070
Identities = 19/49 (38%), Positives = 26/49 (53%)
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
+VN N+ G TPLH AA + + L+ GAN + KD T +H A
Sbjct: 154 KVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 202
Score = 30.0 bits (66), Expect = 0.78
Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 11 CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70
CN+ Y ++ + ++A + D T LH + S+GH +IV+ LL+ G +
Sbjct: 203 CNVGYY----DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQAN 258
Query: 71 DAGWSPLHIAASAGRDEIVK 90
G P+ +A + + ++K
Sbjct: 259 KHGERPVDVAETEELELLLK 278
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 77.0 bits (188), Expect = 6e-15
Identities = 43/111 (38%), Positives = 58/111 (52%), Gaps = 1/111 (0%)
Query: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
K + ++ T LH A G + V+ L+ LG VN KD AGW+PLH A + G ++
Sbjct: 175 KDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVA 234
Query: 90 KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP-DAKDHYE 139
K L+ GA VN + TPLH +AS +I +LL G NP A H E
Sbjct: 235 KILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGE 285
Score = 55.1 bits (131), Expect = 2e-08
Identities = 29/83 (34%), Positives = 50/83 (60%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
VN +++ G +PLH+AA G + VK L+ GA VN + G TPLH A + +++A +L
Sbjct: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
Query: 126 LEGGANPDAKDHYEATAMHRAAA 148
+ GA+ + + + T +H +A+
Sbjct: 238 IAAGADVNTQGLDDDTPLHDSAS 260
Score = 52.0 bits (123), Expect = 2e-07
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
A G ++++KE I ++ + D T LH AC+ G+ ++ + L+ G VN +
Sbjct: 193 AIRGDVKQVKELISLGANVNVK-DFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDD 251
Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
+PLH +AS+G +IVK LL G N++G P+ A ++
Sbjct: 252 DTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETE 294
Score = 33.5 bits (75), Expect = 0.070
Identities = 19/49 (38%), Positives = 26/49 (53%)
Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
+VN N+ G TPLH AA + + L+ GAN + KD T +H A
Sbjct: 177 KVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEA 225
Score = 30.0 bits (66), Expect = 0.78
Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 11 CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70
CN+ Y ++ + ++A + D T LH + S+GH +IV+ LL+ G +
Sbjct: 226 CNVGYY----DVAKILIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQAN 281
Query: 71 DAGWSPLHIAASAGRDEIVK 90
G P+ +A + + ++K
Sbjct: 282 KHGERPVDVAETEELELLLK 301
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 76.6 bits (187), Expect = 7e-15
Identities = 41/112 (36%), Positives = 61/112 (54%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + LHWAC G + +VE L+ G +N + +PLH+AAS G +IV+ LL
Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYK 90
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
A +NAVN++G PLHYA + ++A L+ GA + Y + +A A
Sbjct: 91 ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA 142
Score = 61.2 bits (147), Expect = 3e-10
Identities = 31/81 (38%), Positives = 48/81 (59%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N DD G+SPLH A GR +V+ L+ +GA++N +N+ TPLH AAS +I L
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKL 86
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+ A+ +A + + +H A
Sbjct: 87 LQYKADINAVNEHGNVPLHYA 107
Score = 52.0 bits (123), Expect = 2e-07
Identities = 29/77 (37%), Positives = 43/77 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A S GH +IV+ LLQ +N ++ G PLH A G+D++ + L+ GA V+
Sbjct: 69 TPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Query: 102 VNQNGCTPLHYAASKNR 118
N+ G P+ A + R
Sbjct: 129 CNKYGEMPVDKAKAPLR 145
Score = 32.3 bits (72), Expect = 0.16
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+N + +G +PLH+A + R + ML+ GA + + + T +H AA+
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAAS 76
Score = 28.1 bits (61), Expect = 3.0
Identities = 20/91 (21%), Positives = 41/91 (45%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
+LA S ++ + +L K+ ++ LH+AC G ++ E L+ G V+ +
Sbjct: 72 HLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNK 131
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
G P+ A + R+ + + G +N +
Sbjct: 132 YGEMPVDKAKAPLRELLRERAEKMGQNLNRI 162
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 76.6 bits (187), Expect = 7e-15
Identities = 41/112 (36%), Positives = 61/112 (54%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + LHWAC G + +VE L+ G +N + +PLH+AAS G +IV+ LL
Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYK 90
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
A +NAVN++G PLHYA + ++A L+ GA + Y + +A A
Sbjct: 91 ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA 142
Score = 61.2 bits (147), Expect = 3e-10
Identities = 31/81 (38%), Positives = 48/81 (59%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N DD G+SPLH A GR +V+ L+ +GA++N +N+ TPLH AAS +I L
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKL 86
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+ A+ +A + + +H A
Sbjct: 87 LQYKADINAVNEHGNVPLHYA 107
Score = 52.0 bits (123), Expect = 2e-07
Identities = 29/77 (37%), Positives = 43/77 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A S GH +IV+ LLQ +N ++ G PLH A G+D++ + L+ GA V+
Sbjct: 69 TPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Query: 102 VNQNGCTPLHYAASKNR 118
N+ G P+ A + R
Sbjct: 129 CNKYGEMPVDKAKAPLR 145
Score = 32.3 bits (72), Expect = 0.16
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+N + +G +PLH+A + R + ML+ GA + + + T +H AA+
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAAS 76
Score = 28.1 bits (61), Expect = 3.0
Identities = 20/91 (21%), Positives = 41/91 (45%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
+LA S ++ + +L K+ ++ LH+AC G ++ E L+ G V+ +
Sbjct: 72 HLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNK 131
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
G P+ A + R+ + + G +N +
Sbjct: 132 YGEMPVDKAKAPLRELLRERAEKMGQNLNRI 162
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 76.6 bits (187), Expect = 7e-15
Identities = 41/112 (36%), Positives = 61/112 (54%)
Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
D + LHWAC G + +VE L+ G +N + +PLH+AAS G +IV+ LL
Sbjct: 31 DDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYK 90
Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
A +NAVN++G PLHYA + ++A L+ GA + Y + +A A
Sbjct: 91 ADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKA 142
Score = 61.2 bits (147), Expect = 3e-10
Identities = 31/81 (38%), Positives = 48/81 (59%)
Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
+N DD G+SPLH A GR +V+ L+ +GA++N +N+ TPLH AAS +I L
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKL 86
Query: 126 LEGGANPDAKDHYEATAMHRA 146
L+ A+ +A + + +H A
Sbjct: 87 LQYKADINAVNEHGNVPLHYA 107
Score = 52.0 bits (123), Expect = 2e-07
Identities = 29/77 (37%), Positives = 43/77 (55%)
Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
T LH A S GH +IV+ LLQ +N ++ G PLH A G+D++ + L+ GA V+
Sbjct: 69 TPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSI 128
Query: 102 VNQNGCTPLHYAASKNR 118
N+ G P+ A + R
Sbjct: 129 CNKYGEMPVDKAKAPLR 145
Score = 32.3 bits (72), Expect = 0.16
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
+N + +G +PLH+A + R + ML+ GA + + + T +H AA+
Sbjct: 27 LNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAAS 76
Score = 28.1 bits (61), Expect = 3.0
Identities = 20/91 (21%), Positives = 41/91 (45%)
Query: 12 NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
+LA S ++ + +L K+ ++ LH+AC G ++ E L+ G V+ +
Sbjct: 72 HLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNK 131
Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
G P+ A + R+ + + G +N +
Sbjct: 132 YGEMPVDKAKAPLRELLRERAEKMGQNLNRI 162
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,407,112
Number of Sequences: 37866
Number of extensions: 206591
Number of successful extensions: 3074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 483
Number of HSP's gapped (non-prelim): 1904
length of query: 151
length of database: 18,247,518
effective HSP length: 93
effective length of query: 58
effective length of database: 14,725,980
effective search space: 854106840
effective search space used: 854106840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.