Guide to the Human Genome
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Search of human proteins with 27894344

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27894344 nuclear receptor subfamily 4, group A, member 1
[Homo sapiens]
         (598 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom...  1227   0.0  
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom...  1227   0.0  
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo...   610   e-175
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof...   509   e-144
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof...   509   e-144
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof...   509   e-144
gi|27894359 nuclear receptor subfamily 4, group A, member 3 isof...   269   5e-72
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     205   1e-52
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   200   4e-51
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     192   6e-49
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   191   2e-48
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     191   2e-48
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  187   2e-47
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    187   3e-47
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  182   1e-45
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]        181   2e-45
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi...   179   5e-45
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi...   179   5e-45
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi...   179   5e-45
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap...   179   5e-45
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo...   177   2e-44
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof...   177   3e-44
gi|238550159 estrogen-related receptor beta [Homo sapiens]            175   9e-44
gi|18860920 estrogen-related receptor alpha [Homo sapiens]            175   1e-43
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom...   163   5e-40
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]         162   6e-40
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]         162   6e-40
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]         162   6e-40
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]          162   6e-40
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   158   2e-38

>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
           sapiens]
          Length = 598

 Score = 1227 bits (3174), Expect = 0.0
 Identities = 598/598 (100%), Positives = 598/598 (100%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY 60
           MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
Sbjct: 1   MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY 60

Query: 61  TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV 120
           TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
Sbjct: 61  TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV 120

Query: 121 DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA 180
           DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
Sbjct: 121 DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA 180

Query: 181 SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL 240
           SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
Sbjct: 181 SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL 240

Query: 241 EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300
           EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
Sbjct: 241 EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300

Query: 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360
           YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
Sbjct: 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360

Query: 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW 420
           PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
Sbjct: 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW 420

Query: 421 AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG 480
           AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
Sbjct: 421 AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG 480

Query: 481 DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540
           DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
Sbjct: 481 DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540

Query: 541 AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
           AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
Sbjct: 541 AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598


>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
           sapiens]
          Length = 598

 Score = 1227 bits (3174), Expect = 0.0
 Identities = 598/598 (100%), Positives = 598/598 (100%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY 60
           MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
Sbjct: 1   MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY 60

Query: 61  TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV 120
           TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
Sbjct: 61  TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV 120

Query: 121 DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA 180
           DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
Sbjct: 121 DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA 180

Query: 181 SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL 240
           SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
Sbjct: 181 SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL 240

Query: 241 EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300
           EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
Sbjct: 241 EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300

Query: 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360
           YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
Sbjct: 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360

Query: 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW 420
           PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
Sbjct: 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW 420

Query: 421 AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG 480
           AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
Sbjct: 421 AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG 480

Query: 481 DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540
           DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
Sbjct: 481 DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA 540

Query: 541 AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
           AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
Sbjct: 541 AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598


>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
           sapiens]
          Length = 598

 Score =  610 bits (1574), Expect = e-175
 Identities = 339/634 (53%), Positives = 419/634 (66%), Gaps = 72/634 (11%)

Query: 1   MPCIQAQYGTPAPSPGPRDH---------LASDPLTPEFIKPTMDLASPEAAPAAPTALP 51
           MPC+QAQYG+      P             +SD LTPEF+K +MDL + E    A T+LP
Sbjct: 1   MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEIT--ATTSLP 58

Query: 52  SFSTFMDGYTGEFDT---FLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQV 108
           SFSTFMD Y+  +D     LYQ+P                      S   +S K ED Q+
Sbjct: 59  SFSTFMDNYSTGYDVKPPCLYQMP---------------------LSGQQSSIKVEDIQM 97

Query: 109 YGCYP-GPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWD--GSFGHFSPSQ 165
           +       L    +E +  SGS YY  P S P+P+TP FQ      WD  GS  +F    
Sbjct: 98  HNYQQHSHLPPQSEEMMPHSGSVYY-KPSSPPTPTTPGFQVQHSPMWDDPGSLHNF---- 152

Query: 166 TYEGLRAWTEQLPKASGPPQPPAFFSF--SPPTGPSPSLAQS-------PLKLFPSQATH 216
            ++   A T  + +   P    + FSF  SPP  P  S           P+   P+  +H
Sbjct: 153 -HQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPA-GSH 210

Query: 217 QLGEGESYSMPT--------AFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCA 268
            + +G+++++P          FPGL         S +LDT V S  +R G+P  +EG CA
Sbjct: 211 HVVDGQTFAVPNPIRKPASMGFPGLQIG----HASQLLDTQVPSPPSR-GSPS-NEGLCA 264

Query: 269 VCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCL 328
           VCGDNA+CQHYGVRTCEGCKGFFKRTVQKNAKY+CLANK+CPVDKRRRNRCQ+CRFQKCL
Sbjct: 265 VCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCL 324

Query: 329 AVGMVKEVVRTDSLKGRRGRLPSKPKQP----PDASPANLLTSLVRAHLDSGPSTAKLDY 384
           AVGMVKEVVRTDSLKGRRGRLPSKPK P    P + P +L+++LVRAH+DS P+   LDY
Sbjct: 325 AVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDY 384

Query: 385 SKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFL 444
           S+FQ         +D   +QQFYDLL+GS+E+IR WAEKIPGFA+L  ADQDLL ESAFL
Sbjct: 385 SRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFL 444

Query: 445 ELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFA 504
           ELF+LRLAYRS P EGKLIFC+G+VLHRLQC RGFG+WIDSI+ FS +L ++ +D+ AF+
Sbjct: 445 ELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFS 504

Query: 505 CLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRT 564
           C++AL ++T+RHGL+EP+RVEELQN+I +CLK+HV    G     + LS+LLGKLPELRT
Sbjct: 505 CIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRT 564

Query: 565 LCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
           LCTQGLQRIFYLKLEDLVPPP IIDK+F+DTLPF
Sbjct: 565 LCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF 598


>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
           b [Homo sapiens]
          Length = 637

 Score =  509 bits (1310), Expect = e-144
 Identities = 312/648 (48%), Positives = 391/648 (60%), Gaps = 72/648 (11%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLA--------SDPLTPEFIKPTMDLASPEAAPAAPTALPS 52
           MPC+QAQY   +PSP    + A        ++ + P++ K TMDL S E    A T+LPS
Sbjct: 12  MPCVQAQY---SPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGSTEITATATTSLPS 68

Query: 53  FSTFMDGYTGEFD---TFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVY 109
            STF++GY+  ++   + +YQ+    +P        + +               +     
Sbjct: 69  ISTFVEGYSSNYELKPSCVYQMQ---RPLIKVEEGRAPSYHHHHHHHHHHHHHHQQQHQQ 125

Query: 110 GCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF----GHFSPSQ 165
              P P S P DE L S+   +  SP S  +P+TP+F P   + WD +     G  +P  
Sbjct: 126 PSIP-PASSPEDEVLPSTSMYFKQSPPS--TPTTPAFPPQAGALWDEALPSAPGCIAPGP 182

Query: 166 TYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPS-----------LAQSPLKLFPSQA 214
               L    + +P  +G   P   F  SPP  P+PS            A + L L P  A
Sbjct: 183 L---LDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAAAALSL-PLGA 238

Query: 215 THQLG------EGESYSMPTA-------FPGLAPTSPHLEGSGILDTP-VTSTKARSGAP 260
               G      E   Y +P A       FP L  T      S + ++P + S  +RS + 
Sbjct: 239 AAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSS 298

Query: 261 GGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQ 320
           G  EG CAVCGDNA+CQHYGVRTCEGCKGFFKRTVQKNAKY+CLANK+CPVDKRRRNRCQ
Sbjct: 299 G--EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQ 356

Query: 321 FCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP---------PDASPANLLTSLVRA 371
           +CRFQKCL+VGMVKEVVRTDSLKGRRGRLPSKPK P         P + P  ++ +LVRA
Sbjct: 357 YCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRA 416

Query: 372 HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELS 431
             DS P    LDYS++        G  DA  VQQFY+LL+ S++V R WAEKIPGF +L 
Sbjct: 417 LTDSTP--RDLDYSRYCPTDQAAAG-TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLP 473

Query: 432 PADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSR 491
             DQ LL+ESAFLELF+LRL+ RS   E K +FC+GLVLHRLQC RGFG+W+DSI  FS 
Sbjct: 474 KEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSL 533

Query: 492 SLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA-AVAGEPQPAS 550
           +L SL +D+ A ACLSAL +IT+RHGL+EP+RVEEL N+I S LK+H +   A EP    
Sbjct: 534 NLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKDHQSKGQALEPTE-- 591

Query: 551 CLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
             S++LG L ELR +CT GLQRIFYLKLEDLV PP IIDK+F+DTLPF
Sbjct: 592 --SKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTLPF 637


>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score =  509 bits (1310), Expect = e-144
 Identities = 312/648 (48%), Positives = 391/648 (60%), Gaps = 72/648 (11%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLA--------SDPLTPEFIKPTMDLASPEAAPAAPTALPS 52
           MPC+QAQY   +PSP    + A        ++ + P++ K TMDL S E    A T+LPS
Sbjct: 1   MPCVQAQY---SPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGSTEITATATTSLPS 57

Query: 53  FSTFMDGYTGEFD---TFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVY 109
            STF++GY+  ++   + +YQ+    +P        + +               +     
Sbjct: 58  ISTFVEGYSSNYELKPSCVYQMQ---RPLIKVEEGRAPSYHHHHHHHHHHHHHHQQQHQQ 114

Query: 110 GCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF----GHFSPSQ 165
              P P S P DE L S+   +  SP S  +P+TP+F P   + WD +     G  +P  
Sbjct: 115 PSIP-PASSPEDEVLPSTSMYFKQSPPS--TPTTPAFPPQAGALWDEALPSAPGCIAPGP 171

Query: 166 TYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPS-----------LAQSPLKLFPSQA 214
               L    + +P  +G   P   F  SPP  P+PS            A + L L P  A
Sbjct: 172 L---LDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAAAALSL-PLGA 227

Query: 215 THQLG------EGESYSMPTA-------FPGLAPTSPHLEGSGILDTP-VTSTKARSGAP 260
               G      E   Y +P A       FP L  T      S + ++P + S  +RS + 
Sbjct: 228 AAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSS 287

Query: 261 GGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQ 320
           G  EG CAVCGDNA+CQHYGVRTCEGCKGFFKRTVQKNAKY+CLANK+CPVDKRRRNRCQ
Sbjct: 288 G--EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQ 345

Query: 321 FCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP---------PDASPANLLTSLVRA 371
           +CRFQKCL+VGMVKEVVRTDSLKGRRGRLPSKPK P         P + P  ++ +LVRA
Sbjct: 346 YCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRA 405

Query: 372 HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELS 431
             DS P    LDYS++        G  DA  VQQFY+LL+ S++V R WAEKIPGF +L 
Sbjct: 406 LTDSTP--RDLDYSRYCPTDQAAAG-TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLP 462

Query: 432 PADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSR 491
             DQ LL+ESAFLELF+LRL+ RS   E K +FC+GLVLHRLQC RGFG+W+DSI  FS 
Sbjct: 463 KEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSL 522

Query: 492 SLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA-AVAGEPQPAS 550
           +L SL +D+ A ACLSAL +IT+RHGL+EP+RVEEL N+I S LK+H +   A EP    
Sbjct: 523 NLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKDHQSKGQALEPTE-- 580

Query: 551 CLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
             S++LG L ELR +CT GLQRIFYLKLEDLV PP IIDK+F+DTLPF
Sbjct: 581 --SKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTLPF 626


>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score =  509 bits (1310), Expect = e-144
 Identities = 312/648 (48%), Positives = 391/648 (60%), Gaps = 72/648 (11%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLA--------SDPLTPEFIKPTMDLASPEAAPAAPTALPS 52
           MPC+QAQY   +PSP    + A        ++ + P++ K TMDL S E    A T+LPS
Sbjct: 1   MPCVQAQY---SPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGSTEITATATTSLPS 57

Query: 53  FSTFMDGYTGEFD---TFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVY 109
            STF++GY+  ++   + +YQ+    +P        + +               +     
Sbjct: 58  ISTFVEGYSSNYELKPSCVYQMQ---RPLIKVEEGRAPSYHHHHHHHHHHHHHHQQQHQQ 114

Query: 110 GCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF----GHFSPSQ 165
              P P S P DE L S+   +  SP S  +P+TP+F P   + WD +     G  +P  
Sbjct: 115 PSIP-PASSPEDEVLPSTSMYFKQSPPS--TPTTPAFPPQAGALWDEALPSAPGCIAPGP 171

Query: 166 TYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPS-----------LAQSPLKLFPSQA 214
               L    + +P  +G   P   F  SPP  P+PS            A + L L P  A
Sbjct: 172 L---LDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAAAALSL-PLGA 227

Query: 215 THQLG------EGESYSMPTA-------FPGLAPTSPHLEGSGILDTP-VTSTKARSGAP 260
               G      E   Y +P A       FP L  T      S + ++P + S  +RS + 
Sbjct: 228 AAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSS 287

Query: 261 GGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQ 320
           G  EG CAVCGDNA+CQHYGVRTCEGCKGFFKRTVQKNAKY+CLANK+CPVDKRRRNRCQ
Sbjct: 288 G--EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQ 345

Query: 321 FCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP---------PDASPANLLTSLVRA 371
           +CRFQKCL+VGMVKEVVRTDSLKGRRGRLPSKPK P         P + P  ++ +LVRA
Sbjct: 346 YCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRA 405

Query: 372 HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELS 431
             DS P    LDYS++        G  DA  VQQFY+LL+ S++V R WAEKIPGF +L 
Sbjct: 406 LTDSTP--RDLDYSRYCPTDQAAAG-TDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLP 462

Query: 432 PADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSR 491
             DQ LL+ESAFLELF+LRL+ RS   E K +FC+GLVLHRLQC RGFG+W+DSI  FS 
Sbjct: 463 KEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSL 522

Query: 492 SLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA-AVAGEPQPAS 550
           +L SL +D+ A ACLSAL +IT+RHGL+EP+RVEEL N+I S LK+H +   A EP    
Sbjct: 523 NLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCNKITSSLKDHQSKGQALEPTE-- 580

Query: 551 CLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
             S++LG L ELR +CT GLQRIFYLKLEDLV PP IIDK+F+DTLPF
Sbjct: 581 --SKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKLFLDTLPF 626


>gi|27894359 nuclear receptor subfamily 4, group A, member 3 isoform
           c [Homo sapiens]
          Length = 443

 Score =  269 bits (688), Expect = 5e-72
 Identities = 182/440 (41%), Positives = 235/440 (53%), Gaps = 66/440 (15%)

Query: 1   MPCIQAQYGTPAPSPGPRDHLA--------SDPLTPEFIKPTMDLASPEAAPAAPTALPS 52
           MPC+QAQY   +PSP    + A        ++ + P++ K TMDL S E    A T+LPS
Sbjct: 1   MPCVQAQY---SPSPPGSSYAAQTYSSEYTTEIMNPDYTKLTMDLGSTEITATATTSLPS 57

Query: 53  FSTFMDGYTGEFD---TFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVY 109
            STF++GY+  ++   + +YQ+    +P        + +               +     
Sbjct: 58  ISTFVEGYSSNYELKPSCVYQMQ---RPLIKVEEGRAPSYHHHHHHHHHHHHHHQQQHQQ 114

Query: 110 GCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSF----GHFSPSQ 165
              P P S P DE L S+   +  SP S  +P+TP+F P   + WD +     G  +P  
Sbjct: 115 PSIP-PASSPEDEVLPSTSMYFKQSPPS--TPTTPAFPPQAGALWDEALPSAPGCIAPGP 171

Query: 166 TYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPS-----------LAQSPLKLFPSQA 214
               L    + +P  +G   P   F  SPP  P+PS            A + L L P  A
Sbjct: 172 L---LDPPMKAVPTVAGARFPLFHFKPSPPHPPAPSPAGGHHLGYDPTAAAALSL-PLGA 227

Query: 215 THQLG------EGESYSMPTA-------FPGLAPTSPHLEGSGILDTP-VTSTKARSGAP 260
               G      E   Y +P A       FP L  T      S + ++P + S  +RS + 
Sbjct: 228 AAAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSS 287

Query: 261 GGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQ 320
           G  EG CAVCGDNA+CQHYGVRTCEGCKGFFKRTVQKNAKY+CLANK+CPVDKRRRNRCQ
Sbjct: 288 G--EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQ 345

Query: 321 FCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP---------PDASPANLLTSLVRA 371
           +CRFQKCL+VGMVKEVVRTDSLKGRRGRLPSKPK P         P + P  ++ +LVRA
Sbjct: 346 YCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRA 405

Query: 372 HLDSGPSTAKLDYSKFQELV 391
             DS P    LDYS+   ++
Sbjct: 406 LTDSTP--RDLDYSRVSFMI 423


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  205 bits (521), Expect = 1e-52
 Identities = 146/418 (34%), Positives = 208/418 (49%), Gaps = 37/418 (8%)

Query: 202 LAQSPLKLFPSQATHQLGEGESY---SMPTAFPGLAPTSPHLE-------GSGILDTP-- 249
           +A +  +LF + A   LG G  Y     P AFPG    SP  E       G G  D P  
Sbjct: 1   MATNKERLFAAGA---LGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKE 57

Query: 250 -------VTSTKARSGAPGGSEGR--------CAVCGDNASCQHYGVRTCEGCKGFFKRT 294
                    ST +    P              C VC D +S  HYGV +CEGCKGFF+R+
Sbjct: 58  MASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 117

Query: 295 VQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK 354
           +QKN  Y C  +K+C ++K  RNRCQ+CR QKC  VGM KE VR D  K ++        
Sbjct: 118 IQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSP 177

Query: 355 QPPDASP--ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
              + SP    L+T + +AH ++ PS  +L           H  + D G   +F +L + 
Sbjct: 178 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSA-DHRVQLDLGLWDKFSELATK 236

Query: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
            +  I ++A+++PGF  LS ADQ  LL++A L++ +LR+  R  P +  + F  GL L+R
Sbjct: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296

Query: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
            Q    GFG   D + AF+  L  L +D      LSA+ LI  DR  L+EP +V++LQ  
Sbjct: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356

Query: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPII 588
           +   L+  + A    P       R+L K+ +LR + T+G +R   LK+E   P PP+I
Sbjct: 357 LLEALR--LYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLI 412


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  200 bits (508), Expect = 4e-51
 Identities = 123/326 (37%), Positives = 180/326 (55%), Gaps = 7/326 (2%)

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           C VC D +S  HYGV +CEGCKGFF+R++QKN  Y C  +K+C ++K  RNRCQ+CR QK
Sbjct: 79  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138

Query: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKLDY 384
           C  VGM KE VR D  K ++           + SP    L+T + +AH ++ PS  +L  
Sbjct: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 198

Query: 385 SKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFL 444
                    H  + D G   +F +L +  +  I ++A+++PGF  LS ADQ  LL++A L
Sbjct: 199 YTTNSSA-DHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 257

Query: 445 ELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAF 503
           ++ +LR+  R  P +  + F  GL L+R Q    GFG   D + AF+  L  L +D    
Sbjct: 258 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 317

Query: 504 ACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPEL 562
             LSA+ LI  DR  L+EP +V++LQ  +   L+  + A    P       R+L K+ +L
Sbjct: 318 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALR--LYARRRRPSQPYMFPRMLMKITDL 375

Query: 563 RTLCTQGLQRIFYLKLEDLVPPPPII 588
           R + T+G +R   LK+E   P PP+I
Sbjct: 376 RGISTKGAERAITLKMEIPGPMPPLI 401


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  192 bits (489), Expect = 6e-49
 Identities = 126/378 (33%), Positives = 195/378 (51%), Gaps = 14/378 (3%)

Query: 225 SMPTAFPGLAPTS-PHLEGSGILDTPVTSTKARSGAPGGS------EGRCAVCGDNASCQ 277
           ++   F GL  T   H   +  ++T  TS++    +P            C VC D +S  
Sbjct: 32  ALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGY 91

Query: 278 HYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVV 337
           HYGV  CEGCKGFF+R++QKN  Y C  +K+C ++K  RNRCQ+CR QKC  VGM KE V
Sbjct: 92  HYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESV 151

Query: 338 RTDSLKGRR--GRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHF 395
           R D  K ++   +          A   +L   + +AH ++ PS  +L           H 
Sbjct: 152 RNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSA-DHR 210

Query: 396 GKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRS 455
            + D G   +F +L +  +  I ++A+++PGF  L+ ADQ  LL++A L++ ILR+  R 
Sbjct: 211 VRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRY 270

Query: 456 KPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT- 513
            P +  + F  GL L+R Q    GFG   D +  F+  L  L +D      LSA+ LI  
Sbjct: 271 TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICG 330

Query: 514 DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRI 573
           DR  L+EP +V++LQ  +   LK ++      P       ++L K+ +LR++  +G +R+
Sbjct: 331 DRQDLEEPTKVDKLQEPLLEALKIYIR--KRRPSKPHMFPKILMKITDLRSISAKGAERV 388

Query: 574 FYLKLEDLVPPPPIIDKI 591
             LK+E     PP+I ++
Sbjct: 389 ITLKMEIPGSMPPLIQEM 406


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  191 bits (485), Expect = 2e-48
 Identities = 144/431 (33%), Positives = 213/431 (49%), Gaps = 39/431 (9%)

Query: 181 SGPPQPPAFFSFSPPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPH 239
           +G P PP  F F P  G  SP  A + L+       HQL     YS P+  P    T   
Sbjct: 17  NGYPVPPYAFFFPPMLGGLSPPGALTTLQ-------HQLPVS-GYSTPS--PATIETQSS 66

Query: 240 LEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNA 299
                +   P      R   P      C VC D +S  HYGV  CEGCKGFF+R++QKN 
Sbjct: 67  SSEEIVPSPPSPPPLPRIYKP------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120

Query: 300 KYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDA 359
            Y C  +K+C ++K  RNRCQ+CR QKC  VGM KE VR D  K ++     +  +    
Sbjct: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180

Query: 360 SP--ANLLTSLVRAHLDSGPSTAKL-----DYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
           +P    L+  + +AH ++ P+  +L     + S  Q + L      D     +F +L + 
Sbjct: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSL------DIDLWDKFSELSTK 234

Query: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
            +    ++A+++PGF  L+ ADQ  LL++A L++ ILR+  R  P +  + F  GL L+R
Sbjct: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294

Query: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
            Q    GFG   D + AF+  L  L +D      LSA+ LI  DR  L++P RV+ LQ  
Sbjct: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354

Query: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDK 590
           +   LK +V      P       ++L K+ +LR++  +G +R+  LK+E     PP+I +
Sbjct: 355 LLEALKVYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQE 412

Query: 591 IF-----MDTL 596
           +      +DTL
Sbjct: 413 MLENSEGLDTL 423


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  191 bits (485), Expect = 2e-48
 Identities = 144/431 (33%), Positives = 213/431 (49%), Gaps = 39/431 (9%)

Query: 181 SGPPQPPAFFSFSPPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPH 239
           +G P PP  F F P  G  SP  A + L+       HQL     YS P+  P    T   
Sbjct: 17  NGYPVPPYAFFFPPMLGGLSPPGALTTLQ-------HQLPVS-GYSTPS--PATIETQSS 66

Query: 240 LEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNA 299
                +   P      R   P      C VC D +S  HYGV  CEGCKGFF+R++QKN 
Sbjct: 67  SSEEIVPSPPSPPPLPRIYKP------CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM 120

Query: 300 KYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDA 359
            Y C  +K+C ++K  RNRCQ+CR QKC  VGM KE VR D  K ++     +  +    
Sbjct: 121 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL 180

Query: 360 SP--ANLLTSLVRAHLDSGPSTAKL-----DYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
           +P    L+  + +AH ++ P+  +L     + S  Q + L      D     +F +L + 
Sbjct: 181 TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSL------DIDLWDKFSELSTK 234

Query: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
            +    ++A+++PGF  L+ ADQ  LL++A L++ ILR+  R  P +  + F  GL L+R
Sbjct: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294

Query: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
            Q    GFG   D + AF+  L  L +D      LSA+ LI  DR  L++P RV+ LQ  
Sbjct: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354

Query: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDK 590
           +   LK +V      P       ++L K+ +LR++  +G +R+  LK+E     PP+I +
Sbjct: 355 LLEALKVYVR--KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQE 412

Query: 591 IF-----MDTL 596
           +      +DTL
Sbjct: 413 MLENSEGLDTL 423


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  187 bits (476), Expect = 2e-47
 Identities = 145/467 (31%), Positives = 225/467 (48%), Gaps = 36/467 (7%)

Query: 134 SPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFS 193
           SP    S + PS  P  L P  GS     P Q +  +   +  +    GPP    F   S
Sbjct: 21  SPTGRGSMAAPSLHP-SLGPGIGS-----PGQLHSPISTLSSPI-NGMGPP----FSVIS 69

Query: 194 PPTGP-SPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTS 252
            P GP S S+  +P   F +      G  +  S            P L  +G+L  P   
Sbjct: 70  SPMGPHSMSVPTTPTLGFST------GSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHP 123

Query: 253 TKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVD 312
           +         ++  CA+CGD +S +HYGV +CEGCKGFFKRTV+K+  Y C  NKDC +D
Sbjct: 124 S---GNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID 180

Query: 313 KRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAH 372
           KR+RNRCQ+CR+QKCLA+GM +E V+ +  +G + R  ++ +    A+    +  ++ A 
Sbjct: 181 KRQRNRCQYCRYQKCLAMGMKREAVQEERQRG-KDRNENEVESTSSANEDMPVERILEAE 239

Query: 373 LDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSP 432
           L   P T    Y +    + P    +   ++ Q  D     L  + +WA++IP F+EL  
Sbjct: 240 LAVEPKTE--TYVEANMGLNPSSPNDPVTNICQAAD---KQLFTLVEWAKRIPHFSELPL 294

Query: 433 ADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILA-FS 490
            DQ +LL + + EL I   ++RS   +  ++  +GL +HR    + G G   D +L    
Sbjct: 295 DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELV 354

Query: 491 RSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPA 549
             +  + +D     CL A+VL   D  GL  P  VE L+ ++ + L+ +       P+  
Sbjct: 355 SKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAY--CKHKYPEQP 412

Query: 550 SCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
              ++LL +LP LR++  + L+ +F+ KL    P    ID   M+ L
Sbjct: 413 GRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP----IDTFLMEML 455


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  187 bits (474), Expect = 3e-47
 Identities = 121/344 (35%), Positives = 185/344 (53%), Gaps = 22/344 (6%)

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           C VC D +S  HYGV  CEGCKGFF+R++QKN  Y C  +K+C ++K  RNRCQ+CR QK
Sbjct: 83  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 142

Query: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKL-- 382
           C  VGM KE VR D  K ++     +  +    +P    L+  + +AH ++ P+  +L  
Sbjct: 143 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 202

Query: 383 ---DYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLL 439
              + S  Q + L      D     +F +L +  +    ++A+++PGF  L+ ADQ  LL
Sbjct: 203 YTTNNSSEQRVSL------DIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLL 256

Query: 440 ESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLV 498
           ++A L++ ILR+  R  P +  + F  GL L+R Q    GFG   D + AF+  L  L +
Sbjct: 257 KAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEM 316

Query: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
           D      LSA+ LI  DR  L++P RV+ LQ  +   LK +V      P       ++L 
Sbjct: 317 DDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR--KRRPSRPHMFPKMLM 374

Query: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIF-----MDTL 596
           K+ +LR++  +G +R+  LK+E     PP+I ++      +DTL
Sbjct: 375 KITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTL 418


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  182 bits (461), Expect = 1e-45
 Identities = 141/453 (31%), Positives = 205/453 (45%), Gaps = 50/453 (11%)

Query: 177 LPKASGPPQPPAFFSFSPPTGPS--PSLAQSPLKLFPSQATHQLGEG-ESYSMPTAFPGL 233
           LP+   PP PP      PP  PS  PSL  S     P      LG      S     PGL
Sbjct: 91  LPQGVPPPSPPG-----PPLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGL 145

Query: 234 APTSP----------------HLEGSGI-----LDTPVTSTKARS-----GAPGGSEGRC 267
            P +P                 L G G      +  PV   +        G PG  +  C
Sbjct: 146 PPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLC 205

Query: 268 AVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKC 327
           A+CGD +S +HYGV +CEGCKGFFKRT++K+  Y C  NKDC VDKR+RNRCQ+CR+QKC
Sbjct: 206 AICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKC 265

Query: 328 LAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANL-LTSLVRAHLDSGPSTAKLDYSK 386
           LA GM +E V+ +    +RG+      +    +P  + +  ++ A L       K D   
Sbjct: 266 LATGMKREAVQEER---QRGKDKDGDGEGAGGAPEEMPVDRILEAEL---AVEQKSDQGV 319

Query: 387 FQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLEL 446
                    G      V          L  + +WA++IP F+ L   DQ +LL + + EL
Sbjct: 320 EGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNEL 379

Query: 447 FILRLAYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILA-FSRSLHSLLVDVPAFA 504
            I   ++RS      ++  +GL +HR    + G G   D +L      +  + +D     
Sbjct: 380 LIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELG 439

Query: 505 CLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELR 563
           CL A++L   D  GL  P  VE L+ ++ + L+ +       P+     ++LL +LP LR
Sbjct: 440 CLRAIILFNPDAKGLSNPSEVEVLREKVYASLETY--CKQKYPEQQGRFAKLLLRLPALR 497

Query: 564 TLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
           ++  + L+ +F+ KL    P    ID   M+ L
Sbjct: 498 SIGLKCLEHLFFFKLIGDTP----IDTFLMEML 526


>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
          Length = 463

 Score =  181 bits (458), Expect = 2e-45
 Identities = 131/421 (31%), Positives = 207/421 (49%), Gaps = 33/421 (7%)

Query: 180 ASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPH 239
           A G P      +  PP+G   +LA  P     +  + QL    S S       L    P 
Sbjct: 65  ALGSPYRVITSAMGPPSG---ALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPL----PG 117

Query: 240 LEGSGILDTPVTSTKARSGAPGGSEGR-CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKN 298
           L G G ++ P TS       PG      CA+CGD +S +HYGV +CEGCKGFFKRT++K+
Sbjct: 118 LPGIGNMNYPSTS-------PGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKD 170

Query: 299 AKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPD 358
             Y C  NKDC +DKR+RNRCQ+CR+QKCL +GM +E V+ +  + R  R  S+ +    
Sbjct: 171 LIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRE-RAESEAECATS 229

Query: 359 ASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIR 418
                 +  ++ A L   P T       + ++ + +   +   ++    D     L  + 
Sbjct: 230 GHEDMPVERILEAELAVEPKT-----ESYGDMNMENSTNDPVTNICHAAD---KQLFTLV 281

Query: 419 KWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQC-AR 477
           +WA++IP F++L+  DQ +LL + + EL I   ++RS   +  ++  +GL +HR    + 
Sbjct: 282 EWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSA 341

Query: 478 GFGDWIDSILA-FSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCL 535
           G G   D +L      +  + +D     CL A+VL   D  GL  P  VE L+ ++ + L
Sbjct: 342 GVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATL 401

Query: 536 KEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDT 595
           + +       P+     ++LL +LP LR++  + L+ +F+ KL    P    ID   M+ 
Sbjct: 402 EAYTK--QKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP----IDTFLMEM 455

Query: 596 L 596
           L
Sbjct: 456 L 456


>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  179 bits (455), Expect = 5e-45
 Identities = 131/388 (33%), Positives = 192/388 (49%), Gaps = 37/388 (9%)

Query: 231 PGLAPTSPHLEGSG------------ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH 278
           P L P++P L GSG            I++ P   TK         +  C VCGD AS  H
Sbjct: 59  PPLYPSAPILGGSGPVRKLYDDCSSTIVEDP--QTKCEYMLNSMPKRLCLVCGDIASGYH 116

Query: 279 YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVR 338
           YGV +CE CK FFKRT+Q N +Y C A  +C + KRRR  CQ CRF KCL VGM+KE VR
Sbjct: 117 YGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVR 176

Query: 339 TDSLKGRRGRLP-------SKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELV 391
            D ++G R +         S    P    PA    + + +HL         +  K   + 
Sbjct: 177 LDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHL------LVAEPEKIYAMP 230

Query: 392 LPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRL 451
            P     D   +    DL    L VI  WA+ IPGF+ LS ADQ  LL+SA++E+ IL +
Sbjct: 231 DPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGV 290

Query: 452 AYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV 510
            YRS   E +L++    ++   Q    G  D  ++IL   +   S+ ++   F  L A+ 
Sbjct: 291 VYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIA 350

Query: 511 LI-TDRHGLQEPRRVEELQNRIASCLKEHVAAVAGE-PQPASCLSRLLGKLPELRTLCTQ 568
           L  +D   +++   V++LQ+ +   L+++ A    E P+ A    ++L  LP LR   T+
Sbjct: 351 LANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRA---GKMLMTLPLLRQTSTK 407

Query: 569 GLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
            +Q  + +KLE  VP    + K+F++ L
Sbjct: 408 AVQHFYNIKLEGKVP----MHKLFLEML 431


>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  179 bits (455), Expect = 5e-45
 Identities = 131/388 (33%), Positives = 192/388 (49%), Gaps = 37/388 (9%)

Query: 231 PGLAPTSPHLEGSG------------ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH 278
           P L P++P L GSG            I++ P   TK         +  C VCGD AS  H
Sbjct: 59  PPLYPSAPILGGSGPVRKLYDDCSSTIVEDP--QTKCEYMLNSMPKRLCLVCGDIASGYH 116

Query: 279 YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVR 338
           YGV +CE CK FFKRT+Q N +Y C A  +C + KRRR  CQ CRF KCL VGM+KE VR
Sbjct: 117 YGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVR 176

Query: 339 TDSLKGRRGRLP-------SKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELV 391
            D ++G R +         S    P    PA    + + +HL         +  K   + 
Sbjct: 177 LDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHL------LVAEPEKIYAMP 230

Query: 392 LPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRL 451
            P     D   +    DL    L VI  WA+ IPGF+ LS ADQ  LL+SA++E+ IL +
Sbjct: 231 DPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGV 290

Query: 452 AYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV 510
            YRS   E +L++    ++   Q    G  D  ++IL   +   S+ ++   F  L A+ 
Sbjct: 291 VYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIA 350

Query: 511 LI-TDRHGLQEPRRVEELQNRIASCLKEHVAAVAGE-PQPASCLSRLLGKLPELRTLCTQ 568
           L  +D   +++   V++LQ+ +   L+++ A    E P+ A    ++L  LP LR   T+
Sbjct: 351 LANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRA---GKMLMTLPLLRQTSTK 407

Query: 569 GLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
            +Q  + +KLE  VP    + K+F++ L
Sbjct: 408 AVQHFYNIKLEGKVP----MHKLFLEML 431


>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  179 bits (455), Expect = 5e-45
 Identities = 131/388 (33%), Positives = 192/388 (49%), Gaps = 37/388 (9%)

Query: 231 PGLAPTSPHLEGSG------------ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH 278
           P L P++P L GSG            I++ P   TK         +  C VCGD AS  H
Sbjct: 82  PPLYPSAPILGGSGPVRKLYDDCSSTIVEDP--QTKCEYMLNSMPKRLCLVCGDIASGYH 139

Query: 279 YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVR 338
           YGV +CE CK FFKRT+Q N +Y C A  +C + KRRR  CQ CRF KCL VGM+KE VR
Sbjct: 140 YGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVR 199

Query: 339 TDSLKGRRGRLP-------SKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELV 391
            D ++G R +         S    P    PA    + + +HL         +  K   + 
Sbjct: 200 LDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHL------LVAEPEKIYAMP 253

Query: 392 LPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRL 451
            P     D   +    DL    L VI  WA+ IPGF+ LS ADQ  LL+SA++E+ IL +
Sbjct: 254 DPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGV 313

Query: 452 AYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV 510
            YRS   E +L++    ++   Q    G  D  ++IL   +   S+ ++   F  L A+ 
Sbjct: 314 VYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIA 373

Query: 511 LI-TDRHGLQEPRRVEELQNRIASCLKEHVAAVAGE-PQPASCLSRLLGKLPELRTLCTQ 568
           L  +D   +++   V++LQ+ +   L+++ A    E P+ A    ++L  LP LR   T+
Sbjct: 374 LANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRA---GKMLMTLPLLRQTSTK 430

Query: 569 GLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
            +Q  + +KLE  VP    + K+F++ L
Sbjct: 431 AVQHFYNIKLEGKVP----MHKLFLEML 454


>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  179 bits (455), Expect = 5e-45
 Identities = 131/388 (33%), Positives = 192/388 (49%), Gaps = 37/388 (9%)

Query: 231 PGLAPTSPHLEGSG------------ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQH 278
           P L P++P L GSG            I++ P   TK         +  C VCGD AS  H
Sbjct: 59  PPLYPSAPILGGSGPVRKLYDDCSSTIVEDP--QTKCEYMLNSMPKRLCLVCGDIASGYH 116

Query: 279 YGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVR 338
           YGV +CE CK FFKRT+Q N +Y C A  +C + KRRR  CQ CRF KCL VGM+KE VR
Sbjct: 117 YGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVR 176

Query: 339 TDSLKGRRGRLP-------SKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELV 391
            D ++G R +         S    P    PA    + + +HL         +  K   + 
Sbjct: 177 LDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHL------LVAEPEKIYAMP 230

Query: 392 LPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRL 451
            P     D   +    DL    L VI  WA+ IPGF+ LS ADQ  LL+SA++E+ IL +
Sbjct: 231 DPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGV 290

Query: 452 AYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV 510
            YRS   E +L++    ++   Q    G  D  ++IL   +   S+ ++   F  L A+ 
Sbjct: 291 VYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIA 350

Query: 511 LI-TDRHGLQEPRRVEELQNRIASCLKEHVAAVAGE-PQPASCLSRLLGKLPELRTLCTQ 568
           L  +D   +++   V++LQ+ +   L+++ A    E P+ A    ++L  LP LR   T+
Sbjct: 351 LANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRA---GKMLMTLPLLRQTSTK 407

Query: 569 GLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
            +Q  + +KLE  VP    + K+F++ L
Sbjct: 408 AVQHFYNIKLEGKVP----MHKLFLEML 431


>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
           sapiens]
          Length = 423

 Score =  177 bits (449), Expect = 2e-44
 Identities = 133/421 (31%), Positives = 197/421 (46%), Gaps = 44/421 (10%)

Query: 195 PTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGS-GILDTPVTST 253
           P GP+P+          +QA    G G       A  G AP +P   G  G   TP T+ 
Sbjct: 20  PGGPNPA----------AQAARGGGGGAGEQQQQAGSG-APHTPQTPGQPGAPATPGTAG 68

Query: 254 KARSGAPGGSEGR----CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDC 309
               G PG  + +    C VCGD +S +HYG  TCEGCK FFKR+V++N  Y C AN++C
Sbjct: 69  DKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNC 128

Query: 310 PVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP-----PDASPAN- 363
           P+D+  RN+CQ+CR +KCL VGM +E V+       RGR+P     P      +  P N 
Sbjct: 129 PIDQHHRNQCQYCRLKKCLKVGMRREAVQ-------RGRMPPTQPNPGQYALTNGDPLNG 181

Query: 364 --LLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWA 421
              L+  +   L + P       S+  +         +   ++   +L +  L    +WA
Sbjct: 182 HCYLSGYISLLLRAEPYPTSRYGSQCMQ-------PNNIMGIENICELAARLLFSAVEWA 234

Query: 422 EKIPGFAELSPADQDLLLESAFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--G 478
             IP F +L   DQ  LL   + ELF+L  A  S P     L+  +GL    +   R   
Sbjct: 235 RNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVA 294

Query: 479 FGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKE 537
           F D I         L +L VD   ++CL A+VL T D  GL +   +E LQ +    L+E
Sbjct: 295 FMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEE 354

Query: 538 HVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLP 597
           +V   +  P   S   +LL +LP LRT+ +  ++++F+++L    P   +I  + +    
Sbjct: 355 YVR--SQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSS 412

Query: 598 F 598
           F
Sbjct: 413 F 413


>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
           a [Homo sapiens]
          Length = 414

 Score =  177 bits (448), Expect = 3e-44
 Identities = 127/401 (31%), Positives = 187/401 (46%), Gaps = 35/401 (8%)

Query: 220 EGESYSMPTAFPGLAPTSPHLEGS----GILDTPVTSTKARSGAPGGSEG---------R 266
           +G   S     PG  P +PH   +    G   TP  +     G PGG             
Sbjct: 19  QGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIE 78

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           C VCGD +S +HYG  TCEGCK FFKR+V++N  Y C AN++CP+D+  RN+CQ+CR +K
Sbjct: 79  CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138

Query: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSK 386
           CL VGM +E V+       RGR+P  P QP     A      +  H       + L   +
Sbjct: 139 CLKVGMRREAVQ-------RGRMP--PTQPTHGQFALTNGDPLNCHSYLSGYISLL--LR 187

Query: 387 FQELVLPHFGKE-----DAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLES 441
            +      FG +     +   ++   +L +  L    +WA  IP F +L   DQ  LL  
Sbjct: 188 AEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRL 247

Query: 442 AFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--GFGDWIDSILAFSRSLHSLLV 498
            + ELF+L  A  S P     L+  +GL    +   R   F D I         L +L V
Sbjct: 248 TWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHV 307

Query: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
           D   ++CL A+VL T D  GL +   VE LQ +    L+E+V   +  P   +   +LL 
Sbjct: 308 DSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVR--SQYPNQPTRFGKLLL 365

Query: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
           +LP LRT+ +  ++++F+++L    P   +I  + +    F
Sbjct: 366 RLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 406


>gi|238550159 estrogen-related receptor beta [Homo sapiens]
          Length = 508

 Score =  175 bits (444), Expect = 9e-44
 Identities = 119/338 (35%), Positives = 173/338 (51%), Gaps = 19/338 (5%)

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           C VCGD AS  HYGV +CE CK FFKRT+Q N +Y C A  +C + KRRR  CQ CRF K
Sbjct: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162

Query: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDY-- 384
           CL VGM+KE VR D ++G  GR   K +   ++SP     SL  +     P T  + Y  
Sbjct: 163 CLKVGMLKEGVRLDRVRG--GRQKYKRRLDSESSP---YLSLQISPPAKKPLTKIVSYLL 217

Query: 385 ----SKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLE 440
                K   +  P   + D   +    DL    L VI  WA+ IPGF+ LS  DQ  LL+
Sbjct: 218 VAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQ 277

Query: 441 SAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVD 499
           SA++E+ IL + YRS P + KL++    ++        G  +   +IL   R    L V+
Sbjct: 278 SAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVE 337

Query: 500 VPAFACLSALVLI-TDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGK 558
              F  L AL L  +D   +++   V++LQ+ +   L+++  +   E    +   +LL  
Sbjct: 338 KEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRT--GKLLLT 395

Query: 559 LPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTL 596
           LP LR    + +Q  + +KL+  VP    + K+F++ L
Sbjct: 396 LPLLRQTAAKAVQHFYSVKLQGKVP----MHKLFLEML 429


>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
          Length = 423

 Score =  175 bits (443), Expect = 1e-43
 Identities = 138/433 (31%), Positives = 199/433 (45%), Gaps = 45/433 (10%)

Query: 178 PKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTS 237
           P +   P+  +     PP   +P  A  P +  P     + GEG                
Sbjct: 17  PASPDSPKGSSETETEPPVALAPGPA--PTRCLPGHKEEEDGEG--------------AG 60

Query: 238 PHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQK 297
           P  +G G L          S  P   +  C VCGD AS  HYGV +CE CK FFKRT+Q 
Sbjct: 61  PGEQGGGKL--------VLSSLP---KRLCLVCGDVASGYHYGVASCEACKAFFKRTIQG 109

Query: 298 NAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQP- 356
           + +Y C A+ +C + KRRR  CQ CRF KCL VGM+KE VR D ++G R +   +P+   
Sbjct: 110 SIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDP 169

Query: 357 ---PDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGD------VQQFY 407
              P   PA  L         + P  A + +    E    +   + AG       V    
Sbjct: 170 LPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLC 229

Query: 408 DLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSG 467
           DL    + V   WA+ IPGF+ LS +DQ  +L+S ++E+ +L +A RS P + +L F   
Sbjct: 230 DLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAED 289

Query: 468 LVLHRLQC-ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLI-TDRHGLQEPRRVE 525
           LVL      A G G+   ++L   R L +L ++   +  L AL L  +D   +++   VE
Sbjct: 290 LVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVE 349

Query: 526 ELQNRIASCLKEHVAAVAGEPQPAS--CLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVP 583
           +L+  +   L E+ A  AG    A      RLL  LP LR    + L   + +KLE  VP
Sbjct: 350 QLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVP 409

Query: 584 PPPIIDKIFMDTL 596
               + K+F++ L
Sbjct: 410 ----MHKLFLEML 418


>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
           sapiens]
          Length = 404

 Score =  163 bits (412), Expect = 5e-40
 Identities = 123/377 (32%), Positives = 175/377 (46%), Gaps = 35/377 (9%)

Query: 247 DTPVTSTKARSGAPGGSEGR------CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK 300
           D   +   A S A  G E R      C VCGD +S +HYGV TCEGCK FFKR++++N  
Sbjct: 30  DDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLS 89

Query: 301 YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS 360
           Y C +N+DC +D+  RN+CQ+CR +KC  VGM KE V+       RGR+P        AS
Sbjct: 90  YTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQ-------RGRIPHSLPGAVAAS 142

Query: 361 PANLLTSLVRAHLDSGPSTAKLDYSKFQELVL---PH---FGKEDAGD--------VQQF 406
             +   S + A    G        S+    +L   P+    G+  AG         +   
Sbjct: 143 SGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNV 202

Query: 407 YDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKP-GEGKLIFC 465
            +L +  L    +WA   P F EL  ADQ  LL  ++ ELF+L  A  + P     L+  
Sbjct: 203 CELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAA 262

Query: 466 SGLVLHRLQCARGFGDWIDSILAFSR---SLHSLLVDVPAFACLSALVLIT-DRHGLQEP 521
           +GL    +   R    ++D + AF      L  L VD   + CL A+ L T D  GL +P
Sbjct: 263 AGLHAAPMAAERAVA-FMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDP 321

Query: 522 RRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDL 581
             VE LQ +    L E+V   A  P       RLL +LP LR +    + ++F+++L   
Sbjct: 322 AHVESLQEKAQVALTEYVR--AQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGK 379

Query: 582 VPPPPIIDKIFMDTLPF 598
            P   +I  + +    F
Sbjct: 380 TPIETLIRDMLLSGSTF 396


>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
          Length = 595

 Score =  162 bits (411), Expect = 6e-40
 Identities = 151/539 (28%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 96  PASASFKFE-----DFQVYGCYPGPLSGPVDEALSSSGSDYYGSP---CSAPSPSTPSFQ 147
           P  A+++F      + QVYG   G   GP  EA +   +   G P     +PSP      
Sbjct: 55  PEGAAYEFNAAAAANAQVYG-QTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHP 113

Query: 148 PPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPL 207
           PPQLSP+               L+   +Q+P          ++  + P+G +   A  P 
Sbjct: 114 PPQLSPF---------------LQPHGQQVP----------YYLENEPSGYTVREAGPPA 148

Query: 208 KLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGR- 266
              P+    + G  E  +                         T+ K         E R 
Sbjct: 149 FYRPNSDNRRQGGRERLAS------------------------TNDKGSMAMESAKETRY 184

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           CAVC D AS  HYGV +CEGCK FFKR++Q +  Y+C A   C +DK RR  CQ CR +K
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRK 244

Query: 327 CLAVGMVKEVVRTDSLKGR-------------RGRL--------------PSKPKQPPDA 359
           C  VGM+K  +R D   GR             RG +              P   K+    
Sbjct: 245 CYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKN 304

Query: 360 SPANLLTS--LVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVI 417
           S A  LT+  +V A LD+ P     +Y        P     +A  +    +L    L  +
Sbjct: 305 SLALSLTADQMVSALLDAEPPILYSEYD-------PTRPFSEASMMGLLTNLADRELVHM 357

Query: 418 RKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQ--C 475
             WA+++PGF +L+  DQ  LLE A+LE+ ++ L +RS    GKL+F   L+L R Q  C
Sbjct: 358 INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKC 417

Query: 476 ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLI---------TDRHGLQEPRRVEE 526
             G  +  D +LA S     + +    F CL +++L+         +    L+E   +  
Sbjct: 418 VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHR 477

Query: 527 LQNRIASCLKEHVAAVAG--EPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVP 583
           + ++I   L  H+ A AG    Q    L++LL  L  +R +  +G++ ++ +K +++VP
Sbjct: 478 VLDKITDTL-IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535


>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
          Length = 595

 Score =  162 bits (411), Expect = 6e-40
 Identities = 151/539 (28%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 96  PASASFKFE-----DFQVYGCYPGPLSGPVDEALSSSGSDYYGSP---CSAPSPSTPSFQ 147
           P  A+++F      + QVYG   G   GP  EA +   +   G P     +PSP      
Sbjct: 55  PEGAAYEFNAAAAANAQVYG-QTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHP 113

Query: 148 PPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPL 207
           PPQLSP+               L+   +Q+P          ++  + P+G +   A  P 
Sbjct: 114 PPQLSPF---------------LQPHGQQVP----------YYLENEPSGYTVREAGPPA 148

Query: 208 KLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGR- 266
              P+    + G  E  +                         T+ K         E R 
Sbjct: 149 FYRPNSDNRRQGGRERLAS------------------------TNDKGSMAMESAKETRY 184

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           CAVC D AS  HYGV +CEGCK FFKR++Q +  Y+C A   C +DK RR  CQ CR +K
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRK 244

Query: 327 CLAVGMVKEVVRTDSLKGR-------------RGRL--------------PSKPKQPPDA 359
           C  VGM+K  +R D   GR             RG +              P   K+    
Sbjct: 245 CYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKN 304

Query: 360 SPANLLTS--LVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVI 417
           S A  LT+  +V A LD+ P     +Y        P     +A  +    +L    L  +
Sbjct: 305 SLALSLTADQMVSALLDAEPPILYSEYD-------PTRPFSEASMMGLLTNLADRELVHM 357

Query: 418 RKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQ--C 475
             WA+++PGF +L+  DQ  LLE A+LE+ ++ L +RS    GKL+F   L+L R Q  C
Sbjct: 358 INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKC 417

Query: 476 ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLI---------TDRHGLQEPRRVEE 526
             G  +  D +LA S     + +    F CL +++L+         +    L+E   +  
Sbjct: 418 VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHR 477

Query: 527 LQNRIASCLKEHVAAVAG--EPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVP 583
           + ++I   L  H+ A AG    Q    L++LL  L  +R +  +G++ ++ +K +++VP
Sbjct: 478 VLDKITDTL-IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535


>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
          Length = 595

 Score =  162 bits (411), Expect = 6e-40
 Identities = 151/539 (28%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 96  PASASFKFE-----DFQVYGCYPGPLSGPVDEALSSSGSDYYGSP---CSAPSPSTPSFQ 147
           P  A+++F      + QVYG   G   GP  EA +   +   G P     +PSP      
Sbjct: 55  PEGAAYEFNAAAAANAQVYG-QTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHP 113

Query: 148 PPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPL 207
           PPQLSP+               L+   +Q+P          ++  + P+G +   A  P 
Sbjct: 114 PPQLSPF---------------LQPHGQQVP----------YYLENEPSGYTVREAGPPA 148

Query: 208 KLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGR- 266
              P+    + G  E  +                         T+ K         E R 
Sbjct: 149 FYRPNSDNRRQGGRERLAS------------------------TNDKGSMAMESAKETRY 184

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           CAVC D AS  HYGV +CEGCK FFKR++Q +  Y+C A   C +DK RR  CQ CR +K
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRK 244

Query: 327 CLAVGMVKEVVRTDSLKGR-------------RGRL--------------PSKPKQPPDA 359
           C  VGM+K  +R D   GR             RG +              P   K+    
Sbjct: 245 CYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKN 304

Query: 360 SPANLLTS--LVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVI 417
           S A  LT+  +V A LD+ P     +Y        P     +A  +    +L    L  +
Sbjct: 305 SLALSLTADQMVSALLDAEPPILYSEYD-------PTRPFSEASMMGLLTNLADRELVHM 357

Query: 418 RKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQ--C 475
             WA+++PGF +L+  DQ  LLE A+LE+ ++ L +RS    GKL+F   L+L R Q  C
Sbjct: 358 INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKC 417

Query: 476 ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLI---------TDRHGLQEPRRVEE 526
             G  +  D +LA S     + +    F CL +++L+         +    L+E   +  
Sbjct: 418 VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHR 477

Query: 527 LQNRIASCLKEHVAAVAG--EPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVP 583
           + ++I   L  H+ A AG    Q    L++LL  L  +R +  +G++ ++ +K +++VP
Sbjct: 478 VLDKITDTL-IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535


>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
          Length = 595

 Score =  162 bits (411), Expect = 6e-40
 Identities = 151/539 (28%), Positives = 230/539 (42%), Gaps = 109/539 (20%)

Query: 96  PASASFKFE-----DFQVYGCYPGPLSGPVDEALSSSGSDYYGSP---CSAPSPSTPSFQ 147
           P  A+++F      + QVYG   G   GP  EA +   +   G P     +PSP      
Sbjct: 55  PEGAAYEFNAAAAANAQVYG-QTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHP 113

Query: 148 PPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPL 207
           PPQLSP+               L+   +Q+P          ++  + P+G +   A  P 
Sbjct: 114 PPQLSPF---------------LQPHGQQVP----------YYLENEPSGYTVREAGPPA 148

Query: 208 KLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGR- 266
              P+    + G  E  +                         T+ K         E R 
Sbjct: 149 FYRPNSDNRRQGGRERLAS------------------------TNDKGSMAMESAKETRY 184

Query: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
           CAVC D AS  HYGV +CEGCK FFKR++Q +  Y+C A   C +DK RR  CQ CR +K
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRK 244

Query: 327 CLAVGMVKEVVRTDSLKGR-------------RGRL--------------PSKPKQPPDA 359
           C  VGM+K  +R D   GR             RG +              P   K+    
Sbjct: 245 CYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKN 304

Query: 360 SPANLLTS--LVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVI 417
           S A  LT+  +V A LD+ P     +Y        P     +A  +    +L    L  +
Sbjct: 305 SLALSLTADQMVSALLDAEPPILYSEYD-------PTRPFSEASMMGLLTNLADRELVHM 357

Query: 418 RKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQ--C 475
             WA+++PGF +L+  DQ  LLE A+LE+ ++ L +RS    GKL+F   L+L R Q  C
Sbjct: 358 INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKC 417

Query: 476 ARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLI---------TDRHGLQEPRRVEE 526
             G  +  D +LA S     + +    F CL +++L+         +    L+E   +  
Sbjct: 418 VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHR 477

Query: 527 LQNRIASCLKEHVAAVAG--EPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVP 583
           + ++I   L  H+ A AG    Q    L++LL  L  +R +  +G++ ++ +K +++VP
Sbjct: 478 VLDKITDTL-IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVP 535


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  158 bits (399), Expect = 2e-38
 Identities = 126/424 (29%), Positives = 199/424 (46%), Gaps = 31/424 (7%)

Query: 185 QPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSG 244
           +P A  + S   G S  + +   ++ P  A    G G   + PTA   L    P  E + 
Sbjct: 22  KPGAQDASSQAQGGSSCILREEARM-PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTE 78

Query: 245 ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICL 304
           I   P    K  +    G+E  C+VCGD AS  HY V +CEGCKGFF+R+V K A YIC 
Sbjct: 79  I--RPQKRKKGPAPKMLGNE-LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICH 135

Query: 305 ANKDCPVDKRRRNRCQFCRFQKCLAVGM------------VKEVVRTDSLKGRRGRLPSK 352
           +   CP+D   R +CQ CR +KC   GM            +K++ R +  +     LP +
Sbjct: 136 SGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPR 195

Query: 353 PKQPPDASP------ANLLTSLVRA--HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQ 404
              PP   P        ++  LV A    +    + +L  + +     PH  +       
Sbjct: 196 ASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFA 255

Query: 405 QFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIF 464
            F +L   S++ I  +A+++PGF +LS  DQ  LL+++ +E+ +L  + R  PG   + F
Sbjct: 256 HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITF 315

Query: 465 CSGLVLHRLQCARG--FGDWIDSILAFSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEP 521
                 +R   A+     ++I+ I  FSR+++ L ++   FA L A+ +   DR  +Q+ 
Sbjct: 316 LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQ 375

Query: 522 RRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDL 581
            +VE LQ+     L  +V+     P       R+L KL  LRTL +   +++F L+L+D 
Sbjct: 376 LQVERLQHTYVEALHAYVS--IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDK 433

Query: 582 VPPP 585
             PP
Sbjct: 434 KLPP 437


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,719,744
Number of Sequences: 37866
Number of extensions: 1724455
Number of successful extensions: 11947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 585
Number of HSP's that attempted gapping in prelim test: 9345
Number of HSP's gapped (non-prelim): 2362
length of query: 598
length of database: 18,247,518
effective HSP length: 108
effective length of query: 490
effective length of database: 14,157,990
effective search space: 6937415100
effective search space used: 6937415100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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