Guide to the Human Genome
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Search of human proteins with 27886568

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886568 interferon induced with helicase C domain 1 [Homo
sapiens]
         (1025 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886568 interferon induced with helicase C domain 1 [Homo sa...  2050   0.0  
gi|149408122 RNA helicase LGP2 [Homo sapiens]                         510   e-144
gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [...   379   e-104
gi|29294649 dicer1 [Homo sapiens]                                      80   1e-14
gi|29294651 dicer1 [Homo sapiens]                                      80   1e-14
gi|74959747 Fanconi anemia, complementation group M [Homo sapiens]     70   8e-12
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s...    50   1e-05
gi|4503529 eukaryotic translation initiation factor 4A isoform 1...    49   2e-05
gi|7661920 eukaryotic translation initiation factor 4A, isoform ...    49   2e-05
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]     45   4e-04
gi|13129006 nucleolar protein GU2 [Homo sapiens]                       45   5e-04
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi...    44   8e-04
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi...    44   8e-04
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ...    44   8e-04
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [...    44   8e-04
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ...    44   8e-04
gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo...    44   0.001
gi|40217847 activating signal cointegrator 1 complex subunit 3-l...    44   0.001
gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD prote...    43   0.001
gi|164419732 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 [Homo sap...    43   0.002
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]          42   0.002
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]           42   0.002
gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked ...    42   0.003
gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [...    42   0.003
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap...    41   0.007
gi|62241024 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 2 [...    40   0.009
gi|62241022 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 3 [...    40   0.009
gi|6005743 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 1 [H...    40   0.009
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]             40   0.009
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]             40   0.009

>gi|27886568 interferon induced with helicase C domain 1 [Homo
            sapiens]
          Length = 1025

 Score = 2050 bits (5311), Expect = 0.0
 Identities = 1025/1025 (100%), Positives = 1025/1025 (100%)

Query: 1    MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVE 60
            MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVE
Sbjct: 1    MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVE 60

Query: 61   LLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNL 120
            LLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNL
Sbjct: 61   LLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNL 120

Query: 121  LQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSA 180
            LQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSA
Sbjct: 121  LQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSA 180

Query: 181  FLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGM 240
            FLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGM
Sbjct: 181  FLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGM 240

Query: 241  ENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARA 300
            ENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARA
Sbjct: 241  ENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARA 300

Query: 301  SPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVI 360
            SPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVI
Sbjct: 301  SPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVI 360

Query: 361  VLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENS 420
            VLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENS
Sbjct: 361  VLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENS 420

Query: 421  LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP 480
            LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP
Sbjct: 421  LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP 480

Query: 481  LPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFA 540
            LPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFA
Sbjct: 481  LPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFA 540

Query: 541  IADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVC 600
            IADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVC
Sbjct: 541  IADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVC 600

Query: 601  AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDE 660
            AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDE
Sbjct: 601  AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDE 660

Query: 661  DDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESAR 720
            DDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESAR
Sbjct: 661  DDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESAR 720

Query: 721  GIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRT 780
            GIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRT
Sbjct: 721  GIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRT 780

Query: 781  GKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGV 840
            GKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGV
Sbjct: 781  GKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGV 840

Query: 841  IEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNP 900
            IEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNP
Sbjct: 841  IEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNP 900

Query: 901  SLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEI 960
            SLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEI
Sbjct: 901  SLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEI 960

Query: 961  ICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCL 1020
            ICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCL
Sbjct: 961  ICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCL 1020

Query: 1021 FSDED 1025
            FSDED
Sbjct: 1021 FSDED 1025


>gi|149408122 RNA helicase LGP2 [Homo sapiens]
          Length = 678

 Score =  510 bits (1314), Expect = e-144
 Identities = 293/717 (40%), Positives = 428/717 (59%), Gaps = 52/717 (7%)

Query: 306  LQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNK 365
            ++LR YQ EV  PALEGKNIII LPTG+GKTR A Y+AK HL+    A    KV+VLVN+
Sbjct: 1    MELRSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVDGA----KVVVLVNR 56

Query: 366  VLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLE 425
            V LV Q   +EF+  L   + V  LSGD   +  F  + +  D++I TA++L+ +L + E
Sbjct: 57   VHLVTQ-HGEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPE 115

Query: 426  NGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQIL 485
              E+  V+L+ FSLI++DECHHT+K+ VYN IM  YL  KL+  +         PLPQ+L
Sbjct: 116  --EEEHVELTVFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQ---------PLPQVL 164

Query: 486  GLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFAIADAT 545
            GLTASPG GGA+K   A  H+L+LCANLD + I + +    QL+   Q+PCK++ +    
Sbjct: 165  GLTASPGTGGASKLDGAINHVLQLCANLDTWCIMSPQNCCPQLQEHSQQPCKQYNLCHRR 224

Query: 546  REDPFKEKLLEIMTRIQTYCQMSPMS-DFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHL 604
             +DPF + L ++M +I  + +M  +S  FGTQ YEQ  +++ + AA  G +++RV A HL
Sbjct: 225  SQDPFGDLLKKLMDQIHDHLEMPELSRKFGTQMYEQQVVKLSEAAALAGLQEQRVYALHL 284

Query: 605  RKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDEDDLK 664
            R+YN+AL I+DT+R +DA   L+ FY+ E   K  ++            C          
Sbjct: 285  RRYNDALLIHDTVRAVDALAALQDFYHREHVTKTQIL------------C---------- 322

Query: 665  KPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIF 724
                    +R L+ LF +    L  LA +   EN KL  L   +  Q++ +  S RGIIF
Sbjct: 323  -------AERRLLALFDDRKNELAHLATHGP-ENPKLEMLEKILQRQFS-SSNSPRGIIF 373

Query: 725  TKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKIN 784
            T+TRQSA++L  W+ + +    V ++A  LIGAG+SS+   MTQ +Q+EVI KF+ G +N
Sbjct: 374  TRTRQSAHSLLLWLQQQQGLQTVDIRAQLLIGAGNSSQSTHMTQRDQQEVIQKFQDGTLN 433

Query: 785  LLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIEHE 844
            LL+AT+VAEEGLDI  CN+V+RYGL+TNEI+MVQARGRARAD+S Y  VA  GS  ++ E
Sbjct: 434  LLVATSVAEEGLDIPHCNVVVRYGLLTNEISMVQARGRARADQSVYAFVATEGSRELKRE 493

Query: 845  TVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNPSLIT 904
             +N+  E +M +A+  VQ M   EY  KI +LQ  ++ ++  +  +   +  +     + 
Sbjct: 494  LINEALETLMEQAVAAVQKMDQAEYQAKIRDLQQAALTKRAAQAAQRENQRQQFPVEHVQ 553

Query: 905  FLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELY-IVRENKALQKKCADYQINGEIICK 963
             LC NC V    G D+  +E  HHVN+ P F   Y + R+   + K   D++  G I C+
Sbjct: 554  LLCINCMVAVGHGSDLRKVEGTHHVNVNPNFSNYYNVSRDPVVINKVFKDWKPGGVISCR 613

Query: 964  -CGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECC 1019
             CG+ WG  M++K + LP LK+R+  ++ +    + Q KKW  +P + P+ D+ + C
Sbjct: 614  NCGEVWGLQMIYKSVKLPVLKVRS--MLLETPQGRIQAKKWSRVPFSVPDFDFLQHC 668


>gi|27881482 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I [Homo
            sapiens]
          Length = 925

 Score =  379 bits (972), Expect = e-104
 Identities = 313/1022 (30%), Positives = 484/1022 (47%), Gaps = 149/1022 (14%)

Query: 12   RYLISCFRARVKMYIQVEPVLDYLT-FLPAEVKEQIQRTVATSGNMQAVELLLSTLEKGV 70
            R  +  F+  ++  +    +L Y+  +   E  + IQ      G M+A  L L  L + +
Sbjct: 6    RRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLE-L 64

Query: 71   WHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNLLQPTLVDKLL 130
               GW R F++AL   G   +  Y   E  D          +EY  LL  LQP    +++
Sbjct: 65   QEEGWFRGFLDALDHAG--YSGLYEAIESWDFKKIE---KLEEYRLLLKRLQPEFKTRII 119

Query: 131  VRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQ--KENWFSAFLNVLRQT 188
              D++   + E L+  E    +      G  +G  +L++ +++  KENW       L + 
Sbjct: 120  PTDIISD-LSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKE 178

Query: 189  GNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGMENNSSESS 248
             N            SE     + +  V+   +E+++ ++ +Q   +++      N SE+S
Sbjct: 179  RNK----------FSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQ--NLSENS 226

Query: 249  FADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARASPEPELQL 308
               S V   SDT+L                                      SP    + 
Sbjct: 227  CPPSEV---SDTNLY-------------------------------------SP---FKP 243

Query: 309  RPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLL 368
            R YQ+E+A PA++GKN IIC PTG GKT V++ I + HL KK    + GKV+   N++ +
Sbjct: 244  RNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHL-KKFPQGQKGKVVFFANQIPV 302

Query: 369  VEQ---LFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLE 425
             EQ   +F K F+   +  YRV G+SG T   +   ++V++ DIII T QIL N   NL+
Sbjct: 303  YEQQKSVFSKYFE---RHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVN---NLK 356

Query: 426  NGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQIL 485
             G      LS F+L+I DECH+T+K+  YN IM +YL QKL  +          PLPQ++
Sbjct: 357  KGTIPS--LSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSG--------PLPQVI 406

Query: 486  GLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFAIADAT 545
            GLTAS GVG A    +A ++I KLCA+LDA  I TVK NL++L+  + +P K F   ++ 
Sbjct: 407  GLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESR 466

Query: 546  REDPFKEKLLEIMTRIQTYCQ-----MSPMS-----DFGTQPYEQWAIQMEKKA----AK 591
              D FK  + ++M   ++  +     +  +S     +FGTQ YEQW + ++K        
Sbjct: 467  ISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMP 526

Query: 592  EGNRKERVC------AEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDS 645
            + + + R+C        HLRKYN+AL I++  RM DA  +L+ F++  +   F  IE D 
Sbjct: 527  DKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQD- 585

Query: 646  DEGGDDEYCDGDEDEDDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLR 705
                                          L   F E  + L+ ++ +P  EN KL  L 
Sbjct: 586  ------------------------------LTQRFEEKLQELESVSRDPSNENPKLEDLC 615

Query: 706  NTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKP 765
              + E+Y    E+   I+F KTR    AL  WI  N K +   +K   L G G +++   
Sbjct: 616  FILQEEYHLNPETIT-ILFVKTRALVDALKNWIEGNPKLS--FLKPGILTGRGKTNQNTG 672

Query: 766  MTQNEQKEVISKFR-TGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRAR 824
            MT   QK ++  F+ +G  N+LIAT+VA+EG+DI +CN+VI Y  V N I M+Q RGR R
Sbjct: 673  MTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGR 732

Query: 825  ADESTYVLVAHSGSGVIEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEK 884
            A  S   L+  S +GVIE E +N ++EKMM  +I  +Q      +  KIL +Q      +
Sbjct: 733  ARGSKCFLLT-SNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIR 791

Query: 885  KMKTKRNIAKHYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVREN 944
              + K       +N       LC+ C  LAC   D+ VIE+ H+  +   FKE ++ R +
Sbjct: 792  DSQEKPKPVPDKENK----KLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPH 847

Query: 945  KALQKKCADYQINGEIIC---KCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYK 1001
                K+ + ++   +I C    C   WG  + +K  ++P +KI +FVV       +  Y 
Sbjct: 848  PK-PKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYS 906

Query: 1002 KW 1003
            KW
Sbjct: 907  KW 908


>gi|29294649 dicer1 [Homo sapiens]
          Length = 1922

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 52/153 (33%), Positives = 86/153 (56%), Gaps = 15/153 (9%)

Query: 721 GIIFTKTRQSAYALSQWITE-NEKFAEVGVKAHHLIGAGHSSEFKPMTQN------EQKE 773
           GIIF + R +A  L++ I E  ++  E+   + + I      + +P  +       +Q+E
Sbjct: 444 GIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEE 503

Query: 774 VISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLV 833
           V+ KFR  + NLLIAT++ EEG+DI +CN+V+R+ L T   + VQ++GRARA  S Y+++
Sbjct: 504 VLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML 563

Query: 834 AHSGSGVIEHETVNDFREKM-MYKAIHCVQNMK 865
           A       + + +  F E +  YKAI  +   K
Sbjct: 564 A-------DTDKIKSFEEDLKTYKAIEKILRNK 589



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 63/209 (30%), Positives = 94/209 (44%), Gaps = 35/209 (16%)

Query: 309 RPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKD-HLDKKKKASEPGK-VIVLVNKV 366
           R YQ+E+ + AL+  N I+CL TGSGKT +AV + K+     +   S  GK  + LVN  
Sbjct: 45  RKYQVELLEAALD-HNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSA 103

Query: 367 -LLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFP-----EVVKSCDIIISTAQILENS 420
             + +Q+        LK     +G   + ++  S+      +      ++I T  +  N 
Sbjct: 104 NQVAQQVSAVRTHSDLK-----VGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNV 158

Query: 421 LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP 480
           L N        + LSD +L++ DECH    +  Y  IM+              EN P   
Sbjct: 159 LKN------GYLSLSDINLLVFDECHLAILDHPYREIMK------------LCENCP--S 198

Query: 481 LPQILGLTASPGVGGATKQAKAEEHILKL 509
            P+ILGLTAS  + G     + EE I KL
Sbjct: 199 CPRILGLTASI-LNGKCDPEELEEKIQKL 226


>gi|29294651 dicer1 [Homo sapiens]
          Length = 1922

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 52/153 (33%), Positives = 86/153 (56%), Gaps = 15/153 (9%)

Query: 721 GIIFTKTRQSAYALSQWITE-NEKFAEVGVKAHHLIGAGHSSEFKPMTQN------EQKE 773
           GIIF + R +A  L++ I E  ++  E+   + + I      + +P  +       +Q+E
Sbjct: 444 GIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEE 503

Query: 774 VISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLV 833
           V+ KFR  + NLLIAT++ EEG+DI +CN+V+R+ L T   + VQ++GRARA  S Y+++
Sbjct: 504 VLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML 563

Query: 834 AHSGSGVIEHETVNDFREKM-MYKAIHCVQNMK 865
           A       + + +  F E +  YKAI  +   K
Sbjct: 564 A-------DTDKIKSFEEDLKTYKAIEKILRNK 589



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 63/209 (30%), Positives = 94/209 (44%), Gaps = 35/209 (16%)

Query: 309 RPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKD-HLDKKKKASEPGK-VIVLVNKV 366
           R YQ+E+ + AL+  N I+CL TGSGKT +AV + K+     +   S  GK  + LVN  
Sbjct: 45  RKYQVELLEAALD-HNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSA 103

Query: 367 -LLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFP-----EVVKSCDIIISTAQILENS 420
             + +Q+        LK     +G   + ++  S+      +      ++I T  +  N 
Sbjct: 104 NQVAQQVSAVRTHSDLK-----VGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNV 158

Query: 421 LLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIP 480
           L N        + LSD +L++ DECH    +  Y  IM+              EN P   
Sbjct: 159 LKN------GYLSLSDINLLVFDECHLAILDHPYREIMK------------LCENCP--S 198

Query: 481 LPQILGLTASPGVGGATKQAKAEEHILKL 509
            P+ILGLTAS  + G     + EE I KL
Sbjct: 199 CPRILGLTASI-LNGKCDPEELEEKIQKL 226


>gi|74959747 Fanconi anemia, complementation group M [Homo sapiens]
          Length = 2048

 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 48/175 (27%), Positives = 84/175 (48%), Gaps = 19/175 (10%)

Query: 696 YENEKLTKLRNTIMEQYT---------RTEESARGIIFTKTRQSAYALSQWITENEKFAE 746
           Y + KL KL   ++E +          +  +  R +IF+  R S   +++ +++++    
Sbjct: 445 YSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPI-- 502

Query: 747 VGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIR 806
             ++    +G       K  TQ EQ EV+ +FR G  N L++T V EEGLDI E +++I 
Sbjct: 503 --IRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIIC 560

Query: 807 YGLVTNEIAMVQARGR-ARADESTYVLVAHSGSGVIEHETVNDFR--EKMMYKAI 858
           +    + I +VQ  GR  R  +   V++   G    E    N  +  ++ +YKAI
Sbjct: 561 FDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGR---EERIYNQSQSNKRSIYKAI 612



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 45/185 (24%), Positives = 79/185 (42%), Gaps = 26/185 (14%)

Query: 308 LRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVL 367
           +R YQ+ +++ AL   N ++CLPTG GKT +A  +  +      +    GKV+ +     
Sbjct: 91  VRDYQLHISRAALFC-NTLVCLPTGLGKTFIAAVVMYNFY----RWFPSGKVVFMAPTKP 145

Query: 368 LVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENG 427
           LV Q     +Q        +  ++G TQ   +  E+  S  ++  T Q++ N L      
Sbjct: 146 LVTQQIEACYQVMGIPQSHMAEMTGSTQAS-TRKEIWCSKRVLFLTPQVMVNDL------ 198

Query: 428 EDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQILGL 487
                  ++   ++IDE H       Y  ++R   + K  N+             +IL L
Sbjct: 199 SRGACPAAEIKCLVIDEAHKALGNYAYCQVVRE--LVKYTNHF------------RILAL 244

Query: 488 TASPG 492
           +A+PG
Sbjct: 245 SATPG 249


>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
           sapiens]
          Length = 407

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 19/136 (13%)

Query: 687 LKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAE 746
           +K+   N E E  KL    +T+ + Y  T    + +IF  TR+       W+TE     +
Sbjct: 247 IKQFYINVEREEWKL----DTLCDLY-ETLTITQAVIFLNTRRKV----DWLTEKMHARD 297

Query: 747 VGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIR 806
             V A H            M Q E+  ++ +FR+G   +LI T +   G+D+++ ++VI 
Sbjct: 298 FTVSALH----------GDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVIN 347

Query: 807 YGLVTNEIAMVQARGR 822
           Y L TN    +   GR
Sbjct: 348 YDLPTNRENYIHRIGR 363


>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
           [Homo sapiens]
          Length = 406

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 37/130 (28%), Positives = 59/130 (45%), Gaps = 19/130 (14%)

Query: 693 NPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAH 752
           N E E  KL    +T+ + Y  T    + +IF  TR+       W+TE     +  V A 
Sbjct: 252 NVEREEWKL----DTLCDLY-ETLTITQAVIFINTRRKV----DWLTEKMHARDFTVSAM 302

Query: 753 HLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTN 812
           H            M Q E+  ++ +FR+G   +LI T +   G+D+++ ++VI Y L TN
Sbjct: 303 H----------GDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTN 352

Query: 813 EIAMVQARGR 822
               +   GR
Sbjct: 353 RENYIHRIGR 362


>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
           [Homo sapiens]
          Length = 411

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 36/145 (24%), Positives = 63/145 (43%), Gaps = 22/145 (15%)

Query: 679 LFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWI 738
           L  E  K      E  E++ + L  L +T+           + +IF  T++       W+
Sbjct: 246 LTLEGIKQFFVAVEREEWKFDTLCDLYDTLT--------ITQAVIFCNTKRKV----DWL 293

Query: 739 TENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDI 798
           TE  + A   V + H            M Q E++ ++ +FR+G   +LI+T V   GLD+
Sbjct: 294 TEKMREANFTVSSMH----------GDMPQKERESIMKEFRSGASRVLISTDVWARGLDV 343

Query: 799 KECNIVIRYGLVTNEIAMVQARGRA 823
            + +++I Y L  N    +   GR+
Sbjct: 344 PQVSLIINYDLPNNRELYIHRIGRS 368


>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
          Length = 614

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 19/133 (14%)

Query: 697 ENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIG 756
           ++EKL +L   IM     +E+  + I+F +T++    L++      K    G  A  + G
Sbjct: 325 KDEKLIRLMEEIM-----SEKENKTIVFVETKRRCDELTR------KMRRDGWPAMGIHG 373

Query: 757 AGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAM 816
                     +Q E+  V+++F+ GK  +LIAT VA  GLD+++   VI Y    +    
Sbjct: 374 --------DKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDY 425

Query: 817 VQARGRARADEST 829
           +   GR      T
Sbjct: 426 IHRIGRTARSTKT 438


>gi|13129006 nucleolar protein GU2 [Homo sapiens]
          Length = 737

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 50/196 (25%), Positives = 83/196 (42%), Gaps = 15/196 (7%)

Query: 252 SSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARASPEPELQLRPY 311
           S  VS  DTS  + S + L+E+L      G+ S    S+   + +  R        L P 
Sbjct: 108 SKRVSSLDTSTHKSSDNKLEETLTREQKEGAFSNFPISEETIKLLKGRGVT----YLFPI 163

Query: 312 QMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKK---KASEPGKVIVLVNKVLL 368
           Q++   P  EGK++I    TG+GKT        + L + +   K S   KV+VL     L
Sbjct: 164 QVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTREL 223

Query: 369 VEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGE 428
             Q+  K+F+   +K   V    G T  +     +    DI++ T   +++ L      +
Sbjct: 224 ANQV-AKDFKDITRK-LSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHL------Q 275

Query: 429 DAGVQLSDFSLIIIDE 444
              + LS    +++DE
Sbjct: 276 SGRLDLSKLRHVVLDE 291



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 17/99 (17%)

Query: 708 IMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMT 767
           +++ Y+ +E   R IIF +T+++       +TE      +   A  L G         + 
Sbjct: 381 VLQVYSGSE--GRAIIFCETKKN-------VTEMAMNPHIKQNAQCLHG--------DIA 423

Query: 768 QNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIR 806
           Q++++  +  FR G   +L+AT VA  GLDI E ++VI+
Sbjct: 424 QSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQ 462


>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo
           sapiens]
          Length = 491

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 20/56 (35%), Positives = 30/56 (53%)

Query: 767 TQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
           TQ ++   +  FR GKI +LI T +   G+D K  N+VI Y   T+ +  +   GR
Sbjct: 339 TQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGR 394



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 7/136 (5%)

Query: 310 PYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLV 369
           P QM+     L G+ ++   PTGSGKT    +     +  K+ A++  + +++     L 
Sbjct: 82  PIQMQAIPVMLHGRELLASAPTGSGKT--LAFSIPILMQLKQPANKGFRALIISPTRELA 139

Query: 370 EQLFRKEFQPFLKKWYRVIGLSGDTQLKISF-PEVVKSCDIIISTAQILENSLLNLENGE 428
            Q+ R+  +      +R+  +         F P+  K  DI+++T     N L+ L   +
Sbjct: 140 SQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTT----PNRLIYLLKQD 195

Query: 429 DAGVQLSDFSLIIIDE 444
             G+ L+    +++DE
Sbjct: 196 PPGIDLASVEWLVVDE 211


>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo
           sapiens]
          Length = 599

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 20/56 (35%), Positives = 30/56 (53%)

Query: 767 TQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
           TQ ++   +  FR GKI +LI T +   G+D K  N+VI Y   T+ +  +   GR
Sbjct: 447 TQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGR 502



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 7/136 (5%)

Query: 310 PYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLV 369
           P QM+     L G+ ++   PTGSGKT    +     +  K+ A++  + +++     L 
Sbjct: 190 PIQMQAIPVMLHGRELLASAPTGSGKT--LAFSIPILMQLKQPANKGFRALIISPTRELA 247

Query: 370 EQLFRKEFQPFLKKWYRVIGLSGDTQLKISF-PEVVKSCDIIISTAQILENSLLNLENGE 428
            Q+ R+  +      +R+  +         F P+  K  DI+++T     N L+ L   +
Sbjct: 248 SQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTT----PNRLIYLLKQD 303

Query: 429 DAGVQLSDFSLIIIDE 444
             G+ L+    +++DE
Sbjct: 304 PPGIDLASVEWLVVDE 319


>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
           [Homo sapiens]
          Length = 724

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 14/145 (9%)

Query: 307 QLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHL-------DKKKKASEPGKV 359
           +L P Q       L G++++ C  TGSGKT   +     H+        + K+  EP  +
Sbjct: 310 KLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECI 369

Query: 360 IVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILEN 419
           IV   +  LV Q++ +  +       R + + G TQL  S  ++V+ C+I+ +T      
Sbjct: 370 IVAPTRE-LVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCAT----PG 424

Query: 420 SLLNLENGEDAGVQLSDFSLIIIDE 444
            L+++   E  G  L     +++DE
Sbjct: 425 RLMDIIGKEKIG--LKQIKYLVLDE 447



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 22/126 (17%)

Query: 697 ENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIG 756
           + EKL ++   I ++ T        ++F +T++ A  ++ ++ + EK +   +       
Sbjct: 527 KREKLVEILRNIGDERT--------MVFVETKKKADFIATFLCQ-EKISTTSIHGDR--- 574

Query: 757 AGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAM 816
                      Q E+++ +  FR GK  +L+AT+VA  GLDI+    VI + L +     
Sbjct: 575 ----------EQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEY 624

Query: 817 VQARGR 822
           V   GR
Sbjct: 625 VHRIGR 630


>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
           [Homo sapiens]
          Length = 724

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 14/145 (9%)

Query: 307 QLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHL-------DKKKKASEPGKV 359
           +L P Q       L G++++ C  TGSGKT   +     H+        + K+  EP  +
Sbjct: 310 KLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECI 369

Query: 360 IVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILEN 419
           IV   +  LV Q++ +  +       R + + G TQL  S  ++V+ C+I+ +T      
Sbjct: 370 IVAPTRE-LVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCAT----PG 424

Query: 420 SLLNLENGEDAGVQLSDFSLIIIDE 444
            L+++   E  G  L     +++DE
Sbjct: 425 RLMDIIGKEKIG--LKQIKYLVLDE 447



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 22/126 (17%)

Query: 697 ENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIG 756
           + EKL ++   I ++ T        ++F +T++ A  ++ ++ + EK +   +       
Sbjct: 527 KREKLVEILRNIGDERT--------MVFVETKKKADFIATFLCQ-EKISTTSIHGDR--- 574

Query: 757 AGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAM 816
                      Q E+++ +  FR GK  +L+AT+VA  GLDI+    VI + L +     
Sbjct: 575 ----------EQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEY 624

Query: 817 VQARGR 822
           V   GR
Sbjct: 625 VHRIGR 630


>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
           [Homo sapiens]
          Length = 690

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 14/145 (9%)

Query: 307 QLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHL-------DKKKKASEPGKV 359
           +L P Q       L G++++ C  TGSGKT   +     H+        + K+  EP  +
Sbjct: 276 KLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECI 335

Query: 360 IVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILEN 419
           IV   +  LV Q++ +  +       R + + G TQL  S  ++V+ C+I+ +T      
Sbjct: 336 IVAPTRE-LVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCAT----PG 390

Query: 420 SLLNLENGEDAGVQLSDFSLIIIDE 444
            L+++   E  G  L     +++DE
Sbjct: 391 RLMDIIGKEKIG--LKQIKYLVLDE 413



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 31/126 (24%), Positives = 58/126 (46%), Gaps = 22/126 (17%)

Query: 697 ENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIG 756
           + EKL ++   I ++ T        ++F +T++ A  ++ ++ + EK +   +       
Sbjct: 493 KREKLVEILRNIGDERT--------MVFVETKKKADFIATFLCQ-EKISTTSIHGDR--- 540

Query: 757 AGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAM 816
                      Q E+++ +  FR GK  +L+AT+VA  GLDI+    VI + L +     
Sbjct: 541 ----------EQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEY 590

Query: 817 VQARGR 822
           V   GR
Sbjct: 591 VHRIGR 596


>gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo
           sapiens]
          Length = 662

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 29/118 (24%), Positives = 56/118 (47%), Gaps = 14/118 (11%)

Query: 705 RNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFK 764
           R+ +++    T + +  ++F +T++ A +L  ++                 G   +S   
Sbjct: 428 RSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHE--------------GYACTSIHG 473

Query: 765 PMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
             +Q +++E + +FR+GK  +L+AT VA  GLDI     VI + L ++    V   GR
Sbjct: 474 DRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGR 531


>gi|40217847 activating signal cointegrator 1 complex subunit 3-like
           1 [Homo sapiens]
          Length = 2136

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 48/194 (24%), Positives = 88/194 (45%), Gaps = 15/194 (7%)

Query: 298 ARASPEPELQLRPYQMEVAQPALE-GKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS-- 354
           A+A  E    L   Q ++ + ALE  +N+++C PTG+GKT VA+      + K       
Sbjct: 471 AQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGT 530

Query: 355 ---EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIII 411
              +  K+I +     LV+++     +        V  L+GD QL     E + +  II+
Sbjct: 531 INVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIV 587

Query: 412 STAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRL 471
            T +  +  ++  + GE    QL    LII+DE H  + +     ++   + + ++N  +
Sbjct: 588 CTPE--KWDIITRKGGERTYTQL--VRLIILDEIHLLHDDR--GPVLEALVARAIRNIEM 641

Query: 472 KKENKPVIPLPQIL 485
            +E+  +I L   L
Sbjct: 642 TQEDVRLIGLSATL 655



 Score = 35.0 bits (79), Expect = 0.36
 Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 16/126 (12%)

Query: 324  NIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFR---KEFQPF 380
            N+ +  PTGSGKT  A +     + +    S  G+ + +     L EQ++    ++FQ  
Sbjct: 1345 NVFVGAPTGSGKTICAEFA----ILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDR 1400

Query: 381  LKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLI 440
            L K  +V+ L+G+T   +   +++   +IIIST +  +  +L+    +   VQ  + +L 
Sbjct: 1401 LNK--KVVLLTGETSTDL---KLLGKGNIIISTPE--KWDILSRRWKQRKNVQ--NINLF 1451

Query: 441  IIDECH 446
            ++DE H
Sbjct: 1452 VVDEVH 1457


>gi|169218225 PREDICTED: similar to U5 snRNP-specific 200kD protein,
           partial [Homo sapiens]
          Length = 1700

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/194 (24%), Positives = 88/194 (45%), Gaps = 15/194 (7%)

Query: 298 ARASPEPELQLRPYQMEVAQPALE-GKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS-- 354
           A+A  E    L   Q ++ + ALE  +N+++C PTG+GKT VA+      + K       
Sbjct: 35  AQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGT 94

Query: 355 ---EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIII 411
              +  K+I +     LV+++     +        V  L+GD QL     E + +  II+
Sbjct: 95  INVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQL---CKEEISATQIIV 151

Query: 412 STAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRL 471
            T +  +  ++  + GE    QL    LI++DE H  + +     ++   + + ++N  +
Sbjct: 152 CTPE--KWDIITRKGGERTYTQL--VRLIVLDEIHLLHDDR--GPVLEALVARAIRNIEM 205

Query: 472 KKENKPVIPLPQIL 485
            +E+  +I L   L
Sbjct: 206 TQEDVRLIGLSATL 219



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 16/126 (12%)

Query: 324  NIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFR---KEFQPF 380
            N+ +  PTGSGKT  A +     L +  +    G+ + +    L  EQ++    ++FQ  
Sbjct: 909  NVFVGAPTGSGKTICAEFAILRMLLQNSE----GRCVYITPMRLWQEQVYMDWYEKFQDR 964

Query: 381  LKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLI 440
            L K  +V+ L+G+T   +   +++   +IIIST +  +  +L+    +   VQ  + +L 
Sbjct: 965  LNK--KVVLLTGETSTDL---KLLGKGNIIISTPE--KWDILSRRWKQRKNVQ--NINLF 1015

Query: 441  IIDECH 446
            ++DE H
Sbjct: 1016 VVDEVH 1021


>gi|164419732 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 [Homo
           sapiens]
          Length = 483

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 18/92 (19%)

Query: 720 RGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKP--MTQNEQKEVISK 777
           + IIF +TR++A    +W+T              +I  GH        +T  ++  +I +
Sbjct: 340 QAIIFCQTRRNA----KWLTVE------------MIQDGHQVSLLSGELTVEQRASIIQR 383

Query: 778 FRTGKINLLIATTVAEEGLDIKECNIVIRYGL 809
           FR GK  +LI T V   G+D+K+  IV+ + L
Sbjct: 384 FRDGKEKVLITTNVCARGIDVKQVTIVVNFDL 415


>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
          Length = 731

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 22/56 (39%), Positives = 33/56 (58%)

Query: 767 TQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
           +Q E+  V+++FR+GK  +LIAT VA  GLD+++   VI Y    +    V   GR
Sbjct: 453 SQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGR 508


>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
          Length = 729

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 22/56 (39%), Positives = 33/56 (58%)

Query: 767 TQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
           +Q E+  V+++FR+GK  +LIAT VA  GLD+++   VI Y    +    V   GR
Sbjct: 453 SQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGR 508


>gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
           [Homo sapiens]
          Length = 660

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 29/118 (24%), Positives = 55/118 (46%), Gaps = 14/118 (11%)

Query: 705 RNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFK 764
           R+ +++    T   +  ++F +T++ A +L  ++                 G   +S   
Sbjct: 426 RSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHE--------------GYACTSIHG 471

Query: 765 PMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
             +Q +++E + +FR+GK  +L+AT VA  GLDI     VI + L ++    V   GR
Sbjct: 472 DRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGR 529


>gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
           [Homo sapiens]
          Length = 660

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 29/118 (24%), Positives = 55/118 (46%), Gaps = 14/118 (11%)

Query: 705 RNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFK 764
           R+ +++    T   +  ++F +T++ A +L  ++                 G   +S   
Sbjct: 426 RSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHE--------------GYACTSIHG 471

Query: 765 PMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR 822
             +Q +++E + +FR+GK  +L+AT VA  GLDI     VI + L ++    V   GR
Sbjct: 472 DRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGR 529


>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
           sapiens]
          Length = 648

 Score = 40.8 bits (94), Expect = 0.007
 Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 12/133 (9%)

Query: 768 QNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADE 827
           Q ++++ +  F+TGK+ +LIAT +A  GLD+ +   V  +    N    V   GR     
Sbjct: 523 QRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 582

Query: 828 STYVLVAHSGSGVIEHETVNDFR-EKMMYKAIHCVQNMKPEE---YAHKILELQMQSIME 883
            T V +           T ND+R    +   +       PEE    A +    Q +  ME
Sbjct: 583 RTGVSITTL--------TRNDWRVASELINILERANQSIPEELVSMAERFKAHQQKREME 634

Query: 884 KKMKTKRNIAKHY 896
           +KM+  +   K +
Sbjct: 635 RKMERPQGRPKKF 647



 Score = 30.8 bits (68), Expect = 6.8
 Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 12/139 (8%)

Query: 310 PYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHL----DKKKKASEPGKVIVLVNK 365
           P Q +     L+G ++I    TG+GKT   +     HL      K + + PG +++   +
Sbjct: 267 PIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNRPGMLVLTPTR 326

Query: 366 VLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLE 425
            L ++     E   +  K  R + + G         E+ K  DIII+T   L +  L + 
Sbjct: 327 ELALQ--VEGECCKYSYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND--LQMS 382

Query: 426 NGEDAGVQLSDFSLIIIDE 444
           N     V L + + +++DE
Sbjct: 383 N----FVNLKNITYLVLDE 397


>gi|62241024 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 2
           [Homo sapiens]
          Length = 448

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 14/91 (15%)

Query: 719 ARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKF 778
           A+ +IF  TR++A     W+      AE+  + H +  A  S E   M   ++  VI +F
Sbjct: 303 AQAMIFCHTRKTA----SWLA-----AELSKEGHQV--ALLSGE---MMVEQRAAVIERF 348

Query: 779 RTGKINLLIATTVAEEGLDIKECNIVIRYGL 809
           R GK  +L+ T V   G+D+++ ++VI + L
Sbjct: 349 REGKEKVLVTTNVCARGIDVEQVSVVINFDL 379


>gi|62241022 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 3
           [Homo sapiens]
          Length = 370

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 14/91 (15%)

Query: 719 ARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKF 778
           A+ +IF  TR++A     W+      AE+  + H +  A  S E   M   ++  VI +F
Sbjct: 225 AQAMIFCHTRKTA----SWLA-----AELSKEGHQV--ALLSGE---MMVEQRAAVIERF 270

Query: 779 RTGKINLLIATTVAEEGLDIKECNIVIRYGL 809
           R GK  +L+ T V   G+D+++ ++VI + L
Sbjct: 271 REGKEKVLVTTNVCARGIDVEQVSVVINFDL 301


>gi|6005743 DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform 1 [Homo
           sapiens]
          Length = 479

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 14/91 (15%)

Query: 719 ARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKF 778
           A+ +IF  TR++A     W+      AE+  + H +  A  S E   M   ++  VI +F
Sbjct: 334 AQAMIFCHTRKTA----SWLA-----AELSKEGHQV--ALLSGE---MMVEQRAAVIERF 379

Query: 779 RTGKINLLIATTVAEEGLDIKECNIVIRYGL 809
           R GK  +L+ T V   G+D+++ ++VI + L
Sbjct: 380 REGKEKVLVTTNVCARGIDVEQVSVVINFDL 410


>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 7/89 (7%)

Query: 753 HLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGL--- 809
           H +G  H      M Q+E+ +VIS F+   I +L+AT VA  GLDI     VI Y +   
Sbjct: 523 HNLGLLHGD----MDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARD 578

Query: 810 VTNEIAMVQARGRARADESTYVLVAHSGS 838
           +      +   GRA      Y L+    S
Sbjct: 579 IDTHTHRIGRTGRAGEKGVAYTLLTPKDS 607



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 8/140 (5%)

Query: 307 QLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDH-LDKKKKASEPGKVIVLVNK 365
           Q  P Q +    AL G+++I    TGSGKT   ++    H +D+K+     G + V+V  
Sbjct: 275 QPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCP 334

Query: 366 VLLVEQLFRKEFQPFLKKW-YRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNL 424
              + Q    E + F K +  R + + G   +      + +  +I++ T   L      +
Sbjct: 335 TRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRL------I 388

Query: 425 ENGEDAGVQLSDFSLIIIDE 444
           ++ +     L   S ++ DE
Sbjct: 389 DHVKKKATNLQRVSYLVFDE 408


>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
          Length = 938

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 7/89 (7%)

Query: 753 HLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGL--- 809
           H +G  H      M Q+E+ +VIS F+   I +L+AT VA  GLDI     VI Y +   
Sbjct: 523 HNLGLLHGD----MDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARD 578

Query: 810 VTNEIAMVQARGRARADESTYVLVAHSGS 838
           +      +   GRA      Y L+    S
Sbjct: 579 IDTHTHRIGRTGRAGEKGVAYTLLTPKDS 607



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 8/140 (5%)

Query: 307 QLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDH-LDKKKKASEPGKVIVLVNK 365
           Q  P Q +    AL G+++I    TGSGKT   ++    H +D+K+     G + V+V  
Sbjct: 275 QPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCP 334

Query: 366 VLLVEQLFRKEFQPFLKKW-YRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNL 424
              + Q    E + F K +  R + + G   +      + +  +I++ T   L      +
Sbjct: 335 TRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRL------I 388

Query: 425 ENGEDAGVQLSDFSLIIIDE 444
           ++ +     L   S ++ DE
Sbjct: 389 DHVKKKATNLQRVSYLVFDE 408


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,425,393
Number of Sequences: 37866
Number of extensions: 1701918
Number of successful extensions: 7974
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 7141
Number of HSP's gapped (non-prelim): 773
length of query: 1025
length of database: 18,247,518
effective HSP length: 112
effective length of query: 913
effective length of database: 14,006,526
effective search space: 12787958238
effective search space used: 12787958238
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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