Guide to the Human Genome
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Search of human proteins with 27886566

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27886566 mucosa associated lymphoid tissue lymphoma
translocation protein 1 isoform b [Homo sapiens]
         (813 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27886566 mucosa associated lymphoid tissue lymphoma transloca...  1663   0.0  
gi|5803078 mucosa associated lymphoid tissue lymphoma translocat...  1654   0.0  
gi|157168355 CD22 molecule [Homo sapiens]                              67   5e-11
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...    65   2e-10
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...    65   2e-10
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...    64   4e-10
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             63   1e-09
gi|118572606 hemicentin 1 [Homo sapiens]                               61   4e-09
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...    60   6e-09
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...    60   6e-09
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...    60   1e-08
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...    60   1e-08
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...    59   1e-08
gi|7657359 contactin 5 isoform long [Homo sapiens]                     59   1e-08
gi|28373129 contactin 5 isoform short [Homo sapiens]                   59   1e-08
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho...    59   1e-08
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho...    59   1e-08
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...    59   2e-08
gi|109150416 peroxidasin [Homo sapiens]                                59   2e-08
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...    58   3e-08
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...    58   3e-08
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...    58   3e-08
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]       57   7e-08
gi|110349719 titin isoform N2-A [Homo sapiens]                         56   1e-07
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    56   2e-07
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    56   2e-07
gi|19743806 roundabout 1 isoform b [Homo sapiens]                      55   3e-07
gi|4506569 roundabout 1 isoform a [Homo sapiens]                       55   3e-07
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    55   3e-07
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    55   3e-07

>gi|27886566 mucosa associated lymphoid tissue lymphoma
           translocation protein 1 isoform b [Homo sapiens]
          Length = 813

 Score = 1663 bits (4306), Expect = 0.0
 Identities = 813/813 (100%), Positives = 813/813 (100%)

Query: 1   MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL 60
           MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
Sbjct: 1   MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL 60

Query: 61  AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ 120
           AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
Sbjct: 61  AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ 120

Query: 121 LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV 180
           LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
Sbjct: 121 LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV 180

Query: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240
           HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
Sbjct: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240

Query: 241 GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD 300
           GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
Sbjct: 241 GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD 300

Query: 301 SKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTN 360
           SKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTN
Sbjct: 301 SKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTN 360

Query: 361 LLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAP 420
           LLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAP
Sbjct: 361 LLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAP 420

Query: 421 NPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYA 480
           NPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYA
Sbjct: 421 NPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYA 480

Query: 481 TCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIR 540
           TCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIR
Sbjct: 481 TCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIR 540

Query: 541 SSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNV 600
           SSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNV
Sbjct: 541 SSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNV 600

Query: 601 MIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTR 660
           MIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTR
Sbjct: 601 MIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTR 660

Query: 661 LSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCL 720
           LSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCL
Sbjct: 661 LSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCL 720

Query: 721 MSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFA 780
           MSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFA
Sbjct: 721 MSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFA 780

Query: 781 HHASCHFSRSNVPVETTDEIPFSFSDRLRISEK 813
           HHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Sbjct: 781 HHASCHFSRSNVPVETTDEIPFSFSDRLRISEK 813


>gi|5803078 mucosa associated lymphoid tissue lymphoma translocation
           protein 1 isoform a [Homo sapiens]
          Length = 824

 Score = 1654 bits (4284), Expect = 0.0
 Identities = 813/824 (98%), Positives = 813/824 (98%), Gaps = 11/824 (1%)

Query: 1   MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL 60
           MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
Sbjct: 1   MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL 60

Query: 61  AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ 120
           AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
Sbjct: 61  AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ 120

Query: 121 LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV 180
           LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
Sbjct: 121 LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV 180

Query: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240
           HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
Sbjct: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240

Query: 241 GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD 300
           GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
Sbjct: 241 GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD 300

Query: 301 SKKVEIII-----------DELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK 349
           SKKVEIII           DELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
Sbjct: 301 SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK 360

Query: 350 APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF 409
           APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
Sbjct: 361 APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF 420

Query: 410 GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL 469
           GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
Sbjct: 421 GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL 480

Query: 470 KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH 529
           KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
Sbjct: 481 KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH 540

Query: 530 LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI 589
           LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
Sbjct: 541 LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI 600

Query: 590 QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS 649
           QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
Sbjct: 601 QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS 660

Query: 650 KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG 709
           KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
Sbjct: 661 KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG 720

Query: 710 LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS 769
           LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
Sbjct: 721 LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS 780

Query: 770 RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK 813
           RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Sbjct: 781 RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK 824


>gi|157168355 CD22 molecule [Homo sapiens]
          Length = 847

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 51/176 (28%), Positives = 84/176 (47%), Gaps = 20/176 (11%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCR-ATGHPF-VQYQWFKMNKEIPNGNTSELIFNAV 180
           +P  +++        + +G  V L C  ++ HP  VQ+ W K  + +  G  S+L F+++
Sbjct: 504 APRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSI 561

Query: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240
             +DAG Y C VNN+     S+   L+V   P             +L++ + P  Q +M 
Sbjct: 562 SPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPR------------RLRVSMSPGDQ-VME 608

Query: 241 GSTLVLQCVA-VGSPIPHYQWFK-NELPLTHETKKLYMVPYVDLEHQGTYWCHVYN 294
           G +  L C +    P+ HY WF  N   L + ++KL + P V ++H G YWC   N
Sbjct: 609 GKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP-VKVQHSGAYWCQGTN 663



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 46/182 (25%), Positives = 73/182 (40%), Gaps = 17/182 (9%)

Query: 116 TEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGH--PFVQYQWFKMNKEIPNGNTS 173
           T  L +   P ++I V P    V  G  V + C  +     +    W K    +   NT 
Sbjct: 233 TVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF 292

Query: 174 ELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
            L    V    +G Y C+V+N+     S+   L V   PE           S +QI   P
Sbjct: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEP----------STVQILHSP 342

Query: 234 TSQKLMPGSTLVLQCVAVGSPIP-HYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHV 292
             +    GS +   C+++ +P+P +Y W+ N   +   T++   +P +   H GTY C  
Sbjct: 343 AVE----GSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVA 398

Query: 293 YN 294
            N
Sbjct: 399 EN 400



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 2/100 (2%)

Query: 121 LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQ-YQWFKMNKEIPNGNTSELIFNA 179
           L +P  ++++++P  + V+ G+   L C +  +P V  Y WF  N +    ++ +L    
Sbjct: 590 LYAPRRLRVSMSPGDQ-VMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP 648

Query: 180 VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSV 219
           V V+ +G Y C+  N+     S  S L V   PE+  R V
Sbjct: 649 VKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRV 688



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 4/82 (4%)

Query: 226 KLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHY---QWFKNELPLTHETKKLYMVPYVDL 282
           KL+I V P+   +  G ++ + C  V S  P Y    W K+   L  +      +  V  
Sbjct: 243 KLEIKVTPSDAIVREGDSVTMTC-EVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTK 301

Query: 283 EHQGTYWCHVYNDRDSQDSKKV 304
           +  G Y C V ND     S++V
Sbjct: 302 DQSGKYCCQVSNDVGPGRSEEV 323


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
           1 precursor [Homo sapiens]
          Length = 1907

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 50/181 (27%), Positives = 78/181 (43%), Gaps = 23/181 (12%)

Query: 101 CTVTELSDFLQAMEHTEVLQLLS-PPGI-KITVNPESKAVLAGQFVKLCCRATGHPFVQY 158
           CT T     +       VL+    PPG   I + P+ K V   +   + C A G+P  + 
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEI 166

Query: 159 QWFK----MNKEIPNGNTSELIFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVC 209
            WFK    ++    NG   +L   A+ ++     D G Y C   N+    +S  + L V 
Sbjct: 167 SWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYV- 225

Query: 210 DIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTH 269
                       V     +  + P+SQ++MPG ++ L CVAVG+P+P+ +W      LT 
Sbjct: 226 -----------RVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK 274

Query: 270 E 270
           E
Sbjct: 275 E 275



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 47/199 (23%), Positives = 74/199 (37%), Gaps = 35/199 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNK----------EIPNGNTSELIFNAVHV 182
           PE +  L+G      C+ATG P  +  W K  K          E  +G  S L    + V
Sbjct: 39  PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRV 98

Query: 183 -KDAGFYVCRVNNNFTFEFSQWSQLDVCD---IPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C   N+   E +  ++L V +   +P  F  S+D          + P  + +
Sbjct: 99  QRDEAIYECTATNSLG-EINTSAKLSVLEEEQLPPGFP-SID----------MGPQLKVV 146

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK---------LYMVPYVDLEHQGTYW 289
               T  + C A G+P P   WFK+ LP+   T              +   +   QG Y 
Sbjct: 147 EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYE 206

Query: 290 CHVYNDRDSQDSKKVEIII 308
           C   N   ++ S    + +
Sbjct: 207 CVATNSAGTRYSAPANLYV 225


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
           2 precursor [Homo sapiens]
          Length = 1898

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 50/181 (27%), Positives = 78/181 (43%), Gaps = 23/181 (12%)

Query: 101 CTVTELSDFLQAMEHTEVLQLLS-PPGI-KITVNPESKAVLAGQFVKLCCRATGHPFVQY 158
           CT T     +       VL+    PPG   I + P+ K V   +   + C A G+P  + 
Sbjct: 107 CTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEI 166

Query: 159 QWFK----MNKEIPNGNTSELIFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVC 209
            WFK    ++    NG   +L   A+ ++     D G Y C   N+    +S  + L V 
Sbjct: 167 SWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYV- 225

Query: 210 DIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTH 269
                       V     +  + P+SQ++MPG ++ L CVAVG+P+P+ +W      LT 
Sbjct: 226 -----------RVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTK 274

Query: 270 E 270
           E
Sbjct: 275 E 275



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 47/199 (23%), Positives = 74/199 (37%), Gaps = 35/199 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNK----------EIPNGNTSELIFNAVHV 182
           PE +  L+G      C+ATG P  +  W K  K          E  +G  S L    + V
Sbjct: 39  PEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRV 98

Query: 183 -KDAGFYVCRVNNNFTFEFSQWSQLDVCD---IPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C   N+   E +  ++L V +   +P  F  S+D          + P  + +
Sbjct: 99  QRDEAIYECTATNSLG-EINTSAKLSVLEEEQLPPGFP-SID----------MGPQLKVV 146

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK---------LYMVPYVDLEHQGTYW 289
               T  + C A G+P P   WFK+ LP+   T              +   +   QG Y 
Sbjct: 147 EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYE 206

Query: 290 CHVYNDRDSQDSKKVEIII 308
           C   N   ++ S    + +
Sbjct: 207 CVATNSAGTRYSAPANLYV 225


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
           isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 42/151 (27%), Positives = 70/151 (46%), Gaps = 17/151 (11%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSELIFNAVHVK- 183
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L   A+ ++ 
Sbjct: 137 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIES 196

Query: 184 ----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
               D G Y C   N+    +S  + L V ++ E        V     +  + P S ++M
Sbjct: 197 SEETDQGKYECVATNSAGVRYSSPANLYVRELRE--------VRRVAPRFSILPMSHEIM 248

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           PG  + + CVAVGSP+P+ +W +    LT E
Sbjct: 249 PGGNVNITCVAVGSPMPYVKWMQGAEDLTPE 279



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 45/205 (21%), Positives = 75/205 (36%), Gaps = 35/205 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV-----------H 181
           P+ +  ++G      C+ATG P  +  W K  K++ +     + F+              
Sbjct: 39  PKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT 98

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C V  N   E +  ++L V     +P  F  ++D   + K+   VE T    
Sbjct: 99  PRDENVYEC-VAQNSVGEITVHAKLTVLREDQLPSGFP-NIDMGPQLKV---VERT---- 149

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK---------LYMVPYVDLEHQGTYW 289
               T  + C A G+P P   WFK+ LP+                  +   +   QG Y 
Sbjct: 150 ---RTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYE 206

Query: 290 CHVYNDRDSQDSKKVEIIIDELNNL 314
           C   N    + S    + + EL  +
Sbjct: 207 CVATNSAGVRYSSPANLYVRELREV 231


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 51/177 (28%), Positives = 75/177 (42%), Gaps = 15/177 (8%)

Query: 122  LSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT---SELIFN 178
            +SPP   I +   S  V+ GQ + L C     P     W+K    +P+ +    S L  +
Sbjct: 2628 VSPP---IRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLH 2684

Query: 179  AVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKL 238
             + V D+G YVCR NNN     +  + + +   P +   S  G   S + I +E +S  +
Sbjct: 2685 QMSVADSGEYVCRANNNID---ALEASIVISVSPSAGSPSAPG---SSMPIRIESSSSHV 2738

Query: 239  MPGSTLVLQCVAVGSPIPHYQWFK--NELPLTHETK-KLYMVPYVDLEHQGTYWCHV 292
              G TL L CV  G       W K    LP  H+T+     + +V     G Y C V
Sbjct: 2739 AEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRV 2795



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 60/201 (29%), Positives = 79/201 (39%), Gaps = 14/201 (6%)

Query: 101  CTVTELSDFLQAMEHTEVLQL--LSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQY 158
            C  T  +   QA     VL     SPP +KI     S +V  GQ + L C   G    Q 
Sbjct: 2025 CVATSPAGTAQARIQVVVLSASDASPPPVKI--ESSSPSVTEGQTLDLNCVVAGSAHAQV 2082

Query: 159  QWFKMNKEIP---NGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESF 215
             W++    +P     + S L    V   D+G YVCRV N       + + + V  +  + 
Sbjct: 2083 TWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENG---SGPKEASITVSVLHGTH 2139

Query: 216  QR-SVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK--NELPLTHETK 272
               S   V  S   I +EP+S  +  G TL L CV  G       W K    LP  H+T 
Sbjct: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH 2199

Query: 273  -KLYMVPYVDLEHQGTYWCHV 292
              L  +  V     G Y CHV
Sbjct: 2200 GSLLRLHQVTPADSGEYVCHV 2220



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 52/186 (27%), Positives = 76/186 (40%), Gaps = 20/186 (10%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSE--- 174
            VL +    G ++ V+PE   V AG+ V+L CRA G P     W K    +P    SE   
Sbjct: 1947 VLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006

Query: 175  ---LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
               L+  A+   DAGFY+C   +      +  +++ V  +  S          S   + +
Sbjct: 2007 IATLLIPAITTADAGFYLCVATSP---AGTAQARIQVVVLSAS--------DASPPPVKI 2055

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---KLYMVPYVDLEHQGTY 288
            E +S  +  G TL L CV  GS      W++    L   T+       +P V     G Y
Sbjct: 2056 ESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEY 2115

Query: 289  WCHVYN 294
             C V N
Sbjct: 2116 VCRVEN 2121



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 55/187 (29%), Positives = 83/187 (44%), Gaps = 12/187 (6%)

Query: 114  EHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTS 173
            E T +L + SPP    T  PE  +V AG+ V+L C A G P + +QW ++   +P   T+
Sbjct: 3288 EATIILHVESPP--YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATA 3345

Query: 174  E---LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESF-QRSVDGVSESKLQI 229
                L F     +D+G Y CRV N        ++QL V   P S    S+   S   +Q 
Sbjct: 3346 RNELLHFERAAPEDSGRYRCRVTNK-VGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ- 3403

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK--NELPLTHETKK-LYMVPYVDLEHQG 286
             V P  +    G+++   C          +WFK   +LP  H  +  +  +  +D   QG
Sbjct: 3404 -VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQG 3462

Query: 287  TYWCHVY 293
            TY C  +
Sbjct: 3463 TYICQAH 3469



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 55/206 (26%), Positives = 78/206 (37%), Gaps = 20/206 (9%)

Query: 97   GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIK-ITVNPESKAVLAGQFVKLCCRATGHPF 155
            GE  C V   S  L+A     +   + P  I  + +   S  V  GQ + L C   G   
Sbjct: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273

Query: 156  VQYQWFKMNKEIPNGNT---SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIP 212
             Q  W+K    +P  +    S L        DAG YVCR +N      +         + 
Sbjct: 2274 AQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASIT-------VTVT 2326

Query: 213  ESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK--NELPLTHE 270
             +   ++   + S   I +EP+S ++  G TL L CV  G       W K    LP+ H+
Sbjct: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ 2386

Query: 271  TK----KLYMVPYVDLEHQGTYWCHV 292
            T     +LY     D    G Y C V
Sbjct: 2387 THGSLLRLYQASPAD---SGEYVCRV 2409



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 61/224 (27%), Positives = 87/224 (38%), Gaps = 22/224 (9%)

Query: 97   GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKIT----VNPESKAVLAGQFVKLCCRATG 152
            GE  C V   S  L+A     +    S P + +T    +   S  V  GQ + L C   G
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462

Query: 153  HPFVQYQWFKMNKEIPNGNT---SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVC 209
                Q  W K    +P  +    S L    V   D+G YVCRV  +        S     
Sbjct: 2463 QAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGS--------SGTQEA 2514

Query: 210  DIPESFQRSVDGVSESKLQ--ICVEPTSQKLMPGSTLVLQCVAVGSPIPH-YQWFKN--E 264
             +  + Q+ + G     +   + +E +S  L  G TL L C+ V S  PH   W+K    
Sbjct: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCL-VASQAPHTITWYKRGGS 2573

Query: 265  LPLTHE-TKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEII 307
            LP  H+       +P V     G Y CHV N   S+++  +  I
Sbjct: 2574 LPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTI 2617



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 50/190 (26%), Positives = 73/190 (38%), Gaps = 39/190 (20%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTSELI 176
            V+Q L  P + I +    + V+ G  V+  C A G P  Q  W K+   + P    S  +
Sbjct: 3482 VIQAL--PSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGV 3539

Query: 177  FNAVHVK--DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPT 234
                HV+  DAG Y C   N                          G ++S + + V+  
Sbjct: 3540 VRIAHVELADAGQYRCTATN------------------------AAGTTQSHVLLLVQAL 3575

Query: 235  SQKLMP-------GSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---KLYMVPYVDLEH 284
             Q  MP       GS  V  C+A G P P   W K +  L  +++    + M+P V  + 
Sbjct: 3576 PQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQD 3635

Query: 285  QGTYWCHVYN 294
             GTY C   N
Sbjct: 3636 AGTYVCTATN 3645



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 54/212 (25%), Positives = 85/212 (40%), Gaps = 19/212 (8%)

Query: 96   MGEKGCTVTELSDFLQAMEHTEVLQLL------SPPGIKITVNPESKA--VLAGQFVKLC 147
            + + G  V   ++ + A+E + V+ +       S PG  + +  ES +  V  G+ + L 
Sbjct: 2688 VADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLN 2747

Query: 148  CRATGHPFVQYQWFKMNKEIPNGNT---SELIFNAVHVKDAGFYVCRV-NNNFTFEFSQW 203
            C   G    Q  W K    +P+ +    S L  + V   D+G YVCRV  ++   E S  
Sbjct: 2748 CVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVL 2807

Query: 204  SQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK- 262
              ++          +  G       I +EP+S ++  G TL L+CV  G       W K 
Sbjct: 2808 VTIEASGSSAVHVPAPGGAPP----IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKR 2863

Query: 263  -NELPLTHETK-KLYMVPYVDLEHQGTYWCHV 292
               LP  H+    L  +  V     G Y C V
Sbjct: 2864 GGNLPARHQVHGPLLRLNQVSPADSGEYSCQV 2895



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 51/181 (28%), Positives = 72/181 (39%), Gaps = 28/181 (15%)

Query: 123  SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSE---LIFNA 179
            +PP   I + P S  V  GQ + L C   G    Q  W K    +P  +      L  N 
Sbjct: 2826 APP---IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQ 2882

Query: 180  VHVKDAGFYVCRVNNNF-TFEFSQWSQLDVCD---IPESFQRSVDGVSESKLQICVEPTS 235
            V   D+G Y C+V  +  T E S    ++      IP        G+++    I +E +S
Sbjct: 2883 VSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIP------APGLAQP---IYIEASS 2933

Query: 236  QKLMPGSTLVLQCVAVGSPIPHYQWFK--NELPLTHETK----KLYMVPYVDLEHQGTYW 289
              +  G TL L CV  G       W+K    LP  H+T     +L++V   D    G Y 
Sbjct: 2934 SHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPAD---SGEYV 2990

Query: 290  C 290
            C
Sbjct: 2991 C 2991



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 49/194 (25%), Positives = 74/194 (38%), Gaps = 21/194 (10%)

Query: 129  ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP---NGNTSELIFNAVHVKDA 185
            I + P S  V  GQ + L C   G    Q  W K    +P     + S L        D+
Sbjct: 2343 IRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADS 2402

Query: 186  GFYVCRV-NNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
            G YVCRV  ++   E S    ++      +      GV+ +   + +E +S ++  G TL
Sbjct: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPAL-----GVTPT---VRIESSSSQVAEGQTL 2454

Query: 245  VLQCVAVGSPIPHYQWFK--NELPLTHETK----KLYMVPYVDLEHQGTYWCHVYNDRDS 298
             L C+  G       W K    LP  H+      +L  V   D    G Y C V     +
Sbjct: 2455 DLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPAD---SGEYVCRVVGSSGT 2511

Query: 299  QDSKKVEIIIDELN 312
            Q++  +  I   L+
Sbjct: 2512 QEASVLVTIQQRLS 2525



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 45/186 (24%), Positives = 72/186 (38%), Gaps = 25/186 (13%)

Query: 119  LQLLSPPGIKITVNPESKA-VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN-------- 169
            L +  PP   ++V PE    V  G+ V L C + G P    +W +++             
Sbjct: 3106 LSVHGPP--TVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGL 3163

Query: 170  -GNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
              + + L  ++    DAG YVC   N      +   Q++V     +       V   + +
Sbjct: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALG---TAQKQVEVIVDTGAMAPGAPQVQAEEAE 3220

Query: 229  ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---KLYMVPYVDLEHQ 285
            + VE        G T  L+C A GSP P   W K   PL  + +      ++P V  +  
Sbjct: 3221 LTVEA-------GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDS 3273

Query: 286  GTYWCH 291
            G Y C+
Sbjct: 3274 GQYICN 3279



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 51/217 (23%), Positives = 82/217 (37%), Gaps = 28/217 (12%)

Query: 101  CTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPE-SKAVLAGQFVKLCCRATGH-PFVQY 158
            CT   L     +     V +  S P I +TV  + S++V  G  V   C A    P    
Sbjct: 1746 CTCRNLHQSNTSRAELLVTEAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804

Query: 159  QWFKM-NKEIPNGNTSELIFNA------VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDI 211
             W ++ N ++P   T  + FN       V + DAG YVC  +N F  +            
Sbjct: 1805 VWTRLHNGKLP---TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGT--------- 1852

Query: 212  PESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWF---KNELPLT 268
              +      G   + + + + P    + PG     +C A GSP P  +W      +LP  
Sbjct: 1853 -ATLHVQASGTLSAPV-VSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAK 1910

Query: 269  HETK-KLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKV 304
             +    +  +P V+   Q  Y C  ++    Q ++ V
Sbjct: 1911 AQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAV 1947



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/173 (26%), Positives = 70/173 (40%), Gaps = 22/173 (12%)

Query: 129  ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN-KEIPNGNT-----SELIFNAVHV 182
            + V+P    V  G    L C+ +G P   + W + + + +P+G       SEL F +V  
Sbjct: 1679 VEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQP 1738

Query: 183  KDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGS 242
             DAG Y+C   N      S+ ++L V + P          S+       E  SQ + PG+
Sbjct: 1739 SDAGVYICTCRNLHQSNTSR-AELLVTEAP----------SKPITVTVEEQRSQSVRPGA 1787

Query: 243  TLVLQCVAVG-SPIPHYQWFK---NELPL-THETKKLYMVPYVDLEHQGTYWC 290
             +   C A   SP     W +    +LP    +   +  +  V L   GTY C
Sbjct: 1788 DVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVC 1840



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 17/108 (15%)

Query: 97   GEKGCTVTELSDFLQAMEHTEVLQLLSP--------PGIK--ITVNPESKAVLAGQFVKL 146
            GE  C VT  S  L+A     VL  + P        PG+   I +   S  V  GQ + L
Sbjct: 2889 GEYSCQVTGSSGTLEA----SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDL 2944

Query: 147  CCRATGHPFVQYQWFKMNKEIP---NGNTSELIFNAVHVKDAGFYVCR 191
             C   G    Q  W+K    +P     + S+L  + V   D+G YVCR
Sbjct: 2945 NCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 32/221 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            + +L PP I  T  P   +V+  + V L C+  G PF    WFK  K +  G+ +  + +
Sbjct: 1446 IDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD 1505

Query: 179  ---AVHVKDA-----GFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
                +H+K+A     G Y C V+N      +   Q     +      S+ G + +     
Sbjct: 1506 RGQVLHLKNARRNDKGRYQCTVSN------AAGKQAKDIKLTIYIPPSIKGGNVT----- 1554

Query: 231  VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM-------VPYVDLE 283
               T   ++  S + L+C   G P+P   W+K+  P+   ++ LY+       +P   + 
Sbjct: 1555 ---TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVS 1611

Query: 284  HQGTYWCHVYN-DRDSQDSKKVEIIIDEL--NNLGHPDNKE 321
               TY CHV N    ++ S  V++ +  +   NL  P NK+
Sbjct: 1612 DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQ 1652



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/161 (29%), Positives = 69/161 (42%), Gaps = 28/161 (17%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL--- 175
            L +  PP +     P   +VL G+ V+L C A G P    QW K  K I +G T  +   
Sbjct: 3239 LSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVS 3298

Query: 176  -------IFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
                   I+ A+   D G Y C V  N   E  +   L+V   P     ++ G  +    
Sbjct: 3299 ANGSTLNIYGAL-TSDTGKYTC-VATNPAGEEDRIFNLNVYVTP-----TIRGNKDE--- 3348

Query: 229  ICVEPTSQKLMP--GSTLVLQCVAVGSPIPHYQWFKNELPL 267
                  ++KLM    +++ ++C A G+P P   W KN LPL
Sbjct: 3349 ------AEKLMTLVDTSINIECRATGTPPPQINWLKNGLPL 3383



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 45/159 (28%), Positives = 70/159 (44%), Gaps = 24/159 (15%)

Query: 119 LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN----TSE 174
           L +  PP  K+TV P++++   G  V + C ATG+P  +  W   +  I   +    TS+
Sbjct: 606 LTVQEPP--KVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD 663

Query: 175 --LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVE 232
             L       KDAG Y C  +N+   +  Q S L   + P+        V +S+L + + 
Sbjct: 664 GTLFIKNAAPKDAGIYGCLASNSAGTD-KQNSTLRYIEAPKLM------VVQSELLVAL- 715

Query: 233 PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHET 271
                   G   V++C   G P P  +WFK +L L   T
Sbjct: 716 --------GDITVMECKTSGIPPPQVKWFKGDLELRPST 746



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 48/205 (23%), Positives = 81/205 (39%), Gaps = 30/205 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            L++  PP IK      + +VL  Q   L C   G P     W+K N ++   +T + + N
Sbjct: 1353 LKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNN 1412

Query: 179  AVHVK-------DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
               +K       DAG Y C+   N      ++  +DV   P     ++ G +        
Sbjct: 1413 GKILKLFRATPEDAGRYSCKA-INIAGTSQKYFNIDVLVPP-----TIIGTN-------- 1458

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEH------- 284
             P    ++    + L+C   G+P P   WFK+  PL      + ++    + H       
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRN 1518

Query: 285  -QGTYWCHVYNDRDSQDSKKVEIII 308
             +G Y C V N    Q +K +++ I
Sbjct: 1519 DKGRYQCTVSNAAGKQ-AKDIKLTI 1542



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 64/299 (21%), Positives = 112/299 (37%), Gaps = 42/299 (14%)

Query: 92   LLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRAT 151
            LL+  G   C  T  +   +  +H + L +  PP ++      ++ VL    V+L C+A 
Sbjct: 1889 LLEDAGRYTCVATNAAG--ETQQHIQ-LHVHEPPSLEDAGKMLNETVLVSNPVQLECKAA 1945

Query: 152  GHPFVQYQWFKMNKEIPNGNTSELIFN--------AVHVKDAGFYVC-RVNNNFTFEFSQ 202
            G+P     W+K N+ + +G+TS    N        +  + DAG Y C  +N+    E   
Sbjct: 1946 GNPVPVITWYKDNR-LLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFY 2004

Query: 203  WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK 262
              Q+ V         S+ G +     +   P            L+C A G P P   W K
Sbjct: 2005 SLQVHVAP-------SISGSNNMVAVVVNNPVR----------LECEARGIPAPSLTWLK 2047

Query: 263  NELPLTHETK--------KLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL 314
            +  P++  +         ++  +    +   G Y C   N    +       +    N +
Sbjct: 2048 DGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM 2107

Query: 315  GHPDNKEQTTDQ--PLAKDKVALLIGNMNYRE--HPKLKAPLVDVYELTNLLRQLDFKV 369
            G   N      Q   L     A+    + + +  HP LK P + + E  ++L+  D +V
Sbjct: 2108 GEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQV 2166



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 42/173 (24%), Positives = 66/173 (38%), Gaps = 28/173 (16%)

Query: 132  NPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNA-------VHVKD 184
            +PE+ +V+    V L C A+G P     WFK    +   N+  ++            ++D
Sbjct: 2392 SPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMED 2451

Query: 185  AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
            AG Y C V N    E   +  L V   P         V E+ L+        K+    ++
Sbjct: 2452 AGQYTCVVRNAAGEERKIFG-LSVLVPPHI-------VGENTLE------DVKVKEKQSV 2497

Query: 245  VLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGTYWC 290
             L C   G+P+P   W K+  PL  +         +   +  V + H G Y C
Sbjct: 2498 TLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC 2550



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 56/188 (29%), Positives = 71/188 (37%), Gaps = 40/188 (21%)

Query: 124  PPGIK-----ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN-------GN 171
            PP I+      TVN  S+A+L        C A G P     W K N  + N         
Sbjct: 4168 PPRIRSTEGHYTVNENSQAILP-------CVADGIPTPAINWKKDNVLLANLLGKYTAEP 4220

Query: 172  TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
              ELI   V ++D+GFY C V NN   E +    L V  +P +F      VS +K     
Sbjct: 4221 YGELILENVVLEDSGFYTC-VANNAAGEDTHTVSLTVHVLP-TFTELPGDVSLNK----- 4273

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQW-FKNELPLTH----ETKKLYMVPYVDLEHQG 286
                     G  L L C A G P+P   W F N +   H          ++  V  E  G
Sbjct: 4274 ---------GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSG 4324

Query: 287  TYWCHVYN 294
            TY C   N
Sbjct: 4325 TYVCTAEN 4332



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 39/150 (26%), Positives = 62/150 (41%), Gaps = 24/150 (16%)

Query: 133  PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP------NGNTSELIFNAVHVKDAG 186
            P   ++  G+ ++L C+ATG P  +  W   N  IP      NG+ SEL+   V  +D+G
Sbjct: 4266 PGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH-SELVIERVSKEDSG 4324

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVL 246
             YVC   N+  F         V  I   + +             +EP       G   +L
Sbjct: 4325 TYVCTAENSVGF---------VKAIGFVYVKEPPVFKGDYPSNWIEPL------GGNAIL 4369

Query: 247  QCVAVGSPIPHYQWFKN--ELPLTHETKKL 274
             C   G P P  QW +   ++ ++H  ++L
Sbjct: 4370 NCEVKGDPTPTIQWNRKGVDIEISHRIRQL 4399



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/221 (23%), Positives = 89/221 (40%), Gaps = 34/221 (15%)

Query: 122  LSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP---------NGNT 172
            LSP  +KI VN           + L C A   P     W+K  + +          NG+T
Sbjct: 2679 LSPKEVKIKVN---------NTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHT 2729

Query: 173  SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVE 232
             ++      + D G Y C V +N   E      +++  +P SFQ+  +    + L     
Sbjct: 2730 LQI--KEAQISDTGRYTC-VASNIAGEDELDFDVNI-QVPPSFQKLWE--IGNMLDTGRN 2783

Query: 233  PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM-------VPYVDLEHQ 285
              ++ ++  + + L C    +P P   W+K+  PLT   K L +       +P   +E  
Sbjct: 2784 GEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDA 2843

Query: 286  GTYWCHVYNDRDSQDSKK--VEIIIDELNNLGHPDNKEQTT 324
            G Y C   N+   +DS +  V +++  +    + D  E+ T
Sbjct: 2844 GRYTCVAVNEA-GEDSLQYDVRVLVPPIIKGANSDLPEEVT 2883



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 47/187 (25%), Positives = 72/187 (38%), Gaps = 31/187 (16%)

Query: 124  PPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI---------PNGNTSE 174
            PP + I    E+  V+   F+ L C  +G P     W K  + I         P G T +
Sbjct: 2963 PPSV-IGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQ 3021

Query: 175  LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPT 234
            +I     V D G Y C +  N   E  +   L V  +P S +   D  SES   + V   
Sbjct: 3022 II--RAKVSDGGEYTC-IAINQAGESKKKFSLTVY-VPPSIK---DHDSESLSVVNVRE- 3073

Query: 235  SQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGT 287
                  G+++ L+C +   P P   W+KN   +T  T        ++  +   ++   G 
Sbjct: 3074 ------GTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQ 3127

Query: 288  YWCHVYN 294
            Y C   N
Sbjct: 3128 YVCRAIN 3134



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 49/222 (22%), Positives = 85/222 (38%), Gaps = 33/222 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI---------PN 169
            LQ+ +PP +  ++  E   VL G    + C   G P     W +  + +          +
Sbjct: 3428 LQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTH 3487

Query: 170  GNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
            G   +L+      +D+G Y C + +N   E S+   L V + P      ++G SE   +I
Sbjct: 3488 GMVLQLL--KAETEDSGKYTC-IASNEAGEVSKHFILKVLEPPH-----ING-SEEHEEI 3538

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDL 282
             V       +  + L L C+A G P P   W K+  PL    +       ++  +    +
Sbjct: 3539 SV-------IVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQV 3591

Query: 283  EHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTT 324
            E  G Y C + +     D K+  + +    N+   D     T
Sbjct: 3592 EDTGRYTC-LASSPAGDDDKEYLVRVHVPPNIAGTDEPRDIT 3632



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 47/193 (24%), Positives = 66/193 (34%), Gaps = 36/193 (18%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSE---- 174
            LQ+  PP I     P +  V+      L C ATG P     W K N  + N + ++    
Sbjct: 3798 LQVHVPPSI--APGPTNMTVIVNVQTTLACEATGIPKPSINWRK-NGHLLNVDQNQNSYR 3854

Query: 175  ------LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
                  L+  +  V D   Y C V N    +                +R+VD   +    
Sbjct: 3855 LLSSGSLVIISPSVDDTATYECTVTNGAGDD----------------KRTVDLTVQVPPS 3898

Query: 229  ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE-------TKKLYMVPYVD 281
            I  EPT   +   +  V+ C A G P P   W KN + L          +     +    
Sbjct: 3899 IADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQ 3958

Query: 282  LEHQGTYWCHVYN 294
            L H G Y C   N
Sbjct: 3959 LNHAGRYTCVARN 3971



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 48/216 (22%), Positives = 78/216 (36%), Gaps = 35/216 (16%)

Query: 119 LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNK-----------EI 167
           L + SPP       P   ++  G  V L C   G+P    +W +++             I
Sbjct: 787 LDVGSPP--VFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSI 844

Query: 168 PNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
               T  L    +   D G Y+C   N F              I      +V G+    +
Sbjct: 845 SQLRTGALFILNLWASDKGTYICEAENQFG------------KIQSETTVTVTGLVAPLI 892

Query: 228 QICVEPTSQKLMPGSTLVLQCVAV-GSPIPHYQWFKNELPL------THETKKLYMVPYV 280
            I   P+   ++ G  L L C  + G+PIP  +W KN   L      T  +     +  V
Sbjct: 893 GI--SPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERV 950

Query: 281 DLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGH 316
            L+  G Y C V ++    ++K   +++  L  + H
Sbjct: 951 QLQDGGEYTC-VASNVAGTNNKTTSVVVHVLPTIQH 985



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 22/157 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            L +  PP IK        +VL    +KL C   G P     W+K  + I + + +  I  
Sbjct: 1540 LTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDK 1599

Query: 179  AVH-------VKDAGFYVCRVNNNF-TFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
              +       V D+  Y C V N   T E S    +DV  +P   + ++           
Sbjct: 1600 GQYLHIPRAQVSDSATYTCHVANVAGTAEKS--FHVDVY-VPPMIEGNL----------- 1645

Query: 231  VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
              P +++++   +L L+C A G+P P   W K+ +P+
Sbjct: 1646 ATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPV 1682



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 31/169 (18%)

Query: 119  LQLLSPPGIKITVNPESKAVLA--GQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL- 175
            L +  PP I+    PE + ++      V L C ATG P     W K +K I N ++ E+ 
Sbjct: 3145 LNVYVPPSIE---GPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVR 3201

Query: 176  ---------IFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESK 226
                     I  + H  D+G Y C + +N   +  ++  L +  +P S       V+ ++
Sbjct: 3202 ILSGGSKLQIARSQH-SDSGNYTC-IASNMEGKAQKYYFLSI-QVPPS-------VAGAE 3251

Query: 227  LQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL-THETKKL 274
            +     P+   ++ G  + L C A G P P  QW K+  P+ + ET+++
Sbjct: 3252 I-----PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERI 3295



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 49/181 (27%), Positives = 65/181 (35%), Gaps = 30/181 (16%)

Query: 144  VKLCCRATGHPFVQYQWFKMNKEIPNG------NTSELIFNAVHVKDAGFYVCRVNNNFT 197
            + L C A G P     W K  + I         ++  L    V   DAG Y C   N   
Sbjct: 4096 ITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAAN--V 4153

Query: 198  FEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPH 257
               S  S      +P    RS +G         V   SQ ++P       CVA G P P 
Sbjct: 4154 AGSSSTSTKLTVHVPPRI-RSTEG------HYTVNENSQAILP-------CVADGIPTPA 4199

Query: 258  YQWFKNELPLTHETKKLYMVPY-------VDLEHQGTYWCHVYNDRDSQDSKKVEIIIDE 310
              W K+ + L +   K    PY       V LE  G Y C V N+   +D+  V + +  
Sbjct: 4200 INWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTC-VANNAAGEDTHTVSLTVHV 4258

Query: 311  L 311
            L
Sbjct: 4259 L 4259



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 41/191 (21%), Positives = 72/191 (37%), Gaps = 30/191 (15%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            + +L PP I+         V+    ++L C  TG P     W K  + I   +  +++ N
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLN 1786

Query: 179  A-------VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
                      V + G Y C   N       ++       +P + + S  G+SE ++ +  
Sbjct: 1787 GRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEV--TVHVPPTIKSS--GLSE-RVVVKY 1841

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLT--------HETKKLYMVPYVDLE 283
            +P +          LQC+A G P P   W K++ P+           + ++  +    LE
Sbjct: 1842 KPVA----------LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLE 1891

Query: 284  HQGTYWCHVYN 294
              G Y C   N
Sbjct: 1892 DAGRYTCVATN 1902



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 42/165 (25%), Positives = 64/165 (38%), Gaps = 24/165 (14%)

Query: 119  LQLLSPPGIKITVN--PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI 176
            +++L PP IK   +  PE   VL  +   + C ++G P  +  W K  + +   +  + +
Sbjct: 2863 VRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFL 2922

Query: 177  FNA-------VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
             N          + D G YVC V  N      ++  L+V   P     SV G     L +
Sbjct: 2923 SNGRILQILNTQITDIGRYVC-VAENTAGSAKKYFNLNVHVPP-----SVIGPKSENLTV 2976

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKL 274
             V          + + L C   G P P   W KNE P+   T  L
Sbjct: 2977 VVN---------NFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL 3012



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 42/151 (27%), Positives = 60/151 (39%), Gaps = 19/151 (12%)

Query: 126  GIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK------MNKEI---PNGNTSELI 176
            G+    NPE   V+      L C A  +P     WFK       N+ I   P G T +++
Sbjct: 2575 GVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQIL 2634

Query: 177  FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQ 236
             NA    +AG Y C V  N   E  +  ++ V   P   +  + G   S       P   
Sbjct: 2635 -NAQE-DNAGRYSC-VATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLS-------PKEV 2684

Query: 237  KLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
            K+   +TL L+C A   P     W+K+  PL
Sbjct: 2685 KIKVNNTLTLECEAYAIPSASLSWYKDGQPL 2715



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 64/277 (23%), Positives = 99/277 (35%), Gaps = 70/277 (25%)

Query: 78   SLKVLEPEGSPSLCLLKLMGEKGCTVTELS-DFLQAMEHTEVLQLLSPPGIKITVNPESK 136
            S+K+ E   S S   L       C  T ++ +  QA++    L +  PP  KI   P+  
Sbjct: 1134 SMKITETRTSDSGMYL-------CVATNIAGNVTQAVK----LNVHVPP--KIQRGPKHL 1180

Query: 137  AVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNF 196
             V  GQ V + C A G P     W K       G ++ L+    HV          N + 
Sbjct: 1181 KVQVGQRVDIPCNAQGTPLPVITWSK-------GGSTMLVDGEHHVS---------NPDG 1224

Query: 197  TFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVE--PTSQKLMPGSTLVLQ------- 247
            T    Q +  D   I      ++ G  E+++ + V+  PT + L P      Q       
Sbjct: 1225 TLSIDQATPSD-AGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQR 1283

Query: 248  ----CVAVGSPIPHYQWFKNELPLTH--------ETKKLYMVPYVDLEHQGTYWCHVYND 295
                C A G+P P  +W  N   LT         E   L ++  V     G Y C   N+
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE 1343

Query: 296  ------------------RDSQDSKKVEIIIDELNNL 314
                              +D +    V +++++L NL
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNL 1380



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 42/156 (26%), Positives = 54/156 (34%), Gaps = 18/156 (11%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI-- 176
            L +L PP I      E   V   Q V L C  TG+P  +  W K  + +       +I  
Sbjct: 2472 LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISG 2531

Query: 177  -----FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
                    V V   G Y C  ++    +   +S L+V   P       DG  E    I  
Sbjct: 2532 GRFLQITNVQVPHTGRYTCLASSPAGHKSRSFS-LNVFVSPTIAGVGSDGNPEDVTVILN 2590

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             PTS          L C A   P     WFK+  PL
Sbjct: 2591 SPTS----------LVCEAYSYPPATITWFKDGTPL 2616



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 37/153 (24%), Positives = 53/153 (34%), Gaps = 25/153 (16%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF 177
            +L +  PP IK    P+S  +L  +   L C A G P  +  W K    +   +    I 
Sbjct: 3706 ILTVNVPPNIK--GGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSIL 3763

Query: 178  N-------AVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
                    + HV D G Y+C   N                   + +R +D        I 
Sbjct: 3764 ENGFLHIQSAHVTDTGRYLCMATN----------------AAGTDRRRIDLQVHVPPSIA 3807

Query: 231  VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
              PT+  ++      L C A G P P   W KN
Sbjct: 3808 PGPTNMTVIVNVQTTLACEATGIPKPSINWRKN 3840



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 42/167 (25%), Positives = 59/167 (35%), Gaps = 28/167 (16%)

Query: 101  CTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQW 160
            CT      F++A+    V +   PP  K          L G  + L C   G P    QW
Sbjct: 4328 CTAENSVGFVKAIGFVYVKE---PPVFKGDYPSNWIEPLGGNAI-LNCEVKGDPTPTIQW 4383

Query: 161  FKMNKEIPN-------GNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPE 213
             +   +I         GN S  I+  V+ +DAG Y C   N                   
Sbjct: 4384 NRKGVDIEISHRIRQLGNGSLAIYGTVN-EDAGDYTCVATNEAGV--------------- 4427

Query: 214  SFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQW 260
              +RS+    +S   I +EP    +  G  ++L C A G P P   W
Sbjct: 4428 -VERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 33/153 (21%), Positives = 61/153 (39%), Gaps = 21/153 (13%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN-------G 170
            +L++L PP I  +   E  +V+    ++L C A+G P  +  W K  + +P        G
Sbjct: 3520 ILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG 3579

Query: 171  NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
                L  +   V+D G Y C  ++    +  ++  L    +P     ++ G         
Sbjct: 3580 GGEVLRISTAQVEDTGRYTCLASSPAGDDDKEY--LVRVHVPP----NIAGTD------- 3626

Query: 231  VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
             EP    ++    + L+C +   P P   W +N
Sbjct: 3627 -EPRDITVLRNRQVTLECKSDAVPPPVITWLRN 3658



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 40/176 (22%), Positives = 63/176 (35%), Gaps = 28/176 (15%)

Query: 134  ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI-------FNAVHVKDAG 186
            E    L    + + CRATG P  Q  W K    +P  +   L+            V D  
Sbjct: 3350 EKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVA 3409

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVL 246
             Y C  +N    +   ++ L V   P +   S+ G  E             ++ GS+  +
Sbjct: 3410 VYTCVASNRAGVDNKHYN-LQVF-APPNMDNSM-GTEEI-----------TVLKGSSTSM 3455

Query: 247  QCVAVGSPIPHYQWFKNELPL---THETKKLY----MVPYVDLEHQGTYWCHVYND 295
             C+  G+P P   W ++  PL    H T   +     +   + E  G Y C   N+
Sbjct: 3456 ACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNE 3511



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 31/148 (20%), Positives = 54/148 (36%), Gaps = 23/148 (15%)

Query: 132  NPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI---------PNGNTSELIFNAVHV 182
            N E+K V+    + L C     P     W+K    +         P G   ++      V
Sbjct: 2783 NGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQI--PRAKV 2840

Query: 183  KDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGS 242
            +DAG Y C   N    +  Q+      D+       + G +         P    ++   
Sbjct: 2841 EDAGRYTCVAVNEAGEDSLQY------DVRVLVPPIIKGANSDL------PEEVTVLVNK 2888

Query: 243  TLVLQCVAVGSPIPHYQWFKNELPLTHE 270
            + +++C++ GSP P   W K+  PL  +
Sbjct: 2889 SALIECLSSGSPAPRNSWQKDGQPLLED 2916



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 36/163 (22%), Positives = 58/163 (35%), Gaps = 30/163 (18%)

Query: 146  LCCRATGHPFVQYQWFKMN-KEIPNGNTSELIFN------AVHVKDAGFYVCRVNNNFTF 198
            + C A+G PF    W K   + +P G+   ++ +      A  +  AG Y C   N    
Sbjct: 3916 ITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARN---- 3971

Query: 199  EFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHY 258
                           S  R V         I  +P+   ++  + ++L C A G+P P  
Sbjct: 3972 ------------AAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFI 4019

Query: 259  QWFKNELPLTHETKKLYMVPYVDL-------EHQGTYWCHVYN 294
             W K  + +    +   ++P   L       E  GTY C   N
Sbjct: 4020 TWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQN 4062



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 50/220 (22%), Positives = 74/220 (33%), Gaps = 48/220 (21%)

Query: 98   EKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKL-CCRATGHPFV 156
            +KG  + E  +    ++    + +       I ++P    V+ GQ + L C    G+P  
Sbjct: 861  DKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIP 920

Query: 157  QYQWFK------MNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCD 210
            + +W K       N  I   +   L    V ++D G Y C  +N                
Sbjct: 921  ERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN---------------- 964

Query: 211  IPESFQRSVDGVSESKLQICVE--PTSQ------KLMPGSTLVLQCVAVGSPIPHYQWF- 261
                    V G +     + V   PT Q        + G  + L C A G+P P   W  
Sbjct: 965  --------VAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSK 1016

Query: 262  KNELPLTHETK-------KLYMVPYVDLEHQGTYWCHVYN 294
            K EL  T   K        LY+V     E  G Y C   N
Sbjct: 1017 KGELISTSSAKFSAGADGSLYVVS-PGGEESGEYVCTATN 1055



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 6/90 (6%)

Query: 97   GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFV 156
            G+  C  T  +     +E +  L L SPP   IT+ P    + AG  + L C+ATG P  
Sbjct: 4415 GDYTCVATNEAG---VVERSMSLTLQSPP--IITLEPVETVINAGGKIILNCQATGEPQP 4469

Query: 157  QYQWFKMNKEIP-NGNTSELIFNAVHVKDA 185
               W +    I  +   + L  N++++ DA
Sbjct: 4470 TITWSRQGHSISWDDRVNVLSNNSLYIADA 4499



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 35/140 (25%), Positives = 46/140 (32%), Gaps = 23/140 (16%)

Query: 128 KITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN-------TSELIFNAV 180
           K+ V      V  G    + C+ +G P  Q +WFK + E+              L     
Sbjct: 703 KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQET 762

Query: 181 HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP 240
              DAG Y C V  N     +    LDV   P   Q               EP    +  
Sbjct: 763 QDLDAGDYTC-VAINEAGRATGKITLDVGSPPVFIQ---------------EPADVSMEI 806

Query: 241 GSTLVLQCVAVGSPIPHYQW 260
           GS + L C   G P P  +W
Sbjct: 807 GSNVTLPCYVQGYPEPTIKW 826



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 37/161 (22%), Positives = 60/161 (37%), Gaps = 33/161 (20%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP-------NGN 171
            L++  PP I      ++ +VL  Q V+L C++   P     W K    +        + N
Sbjct: 2098 LRVYVPPNIM--GEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISEN 2155

Query: 172  TSELIFNAVHVKDAGFYVCRVNN-----NFTFEFSQWSQLDVCDIPESFQRSVDGVSESK 226
             S L      V+D G Y C   N        +  + W       +P +      G S+  
Sbjct: 2156 RSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW-------VPPNI-----GGSDEL 2203

Query: 227  LQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             Q+ V       + G+ + L C + G P P+  W K   P+
Sbjct: 2204 TQLTV-------IEGNLISLLCESSGIPPPNLIWKKKGSPV 2237



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 32/150 (21%), Positives = 53/150 (35%), Gaps = 29/150 (19%)

Query: 124  PPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI------- 176
            PP I  T  P    VL  + V L C++   P     W +  + +       ++       
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQ 3678

Query: 177  FNAVHVKDAGFYVCRVNN---NFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
             N   + D   Y C  +N     T EF     +   ++P + +                P
Sbjct: 3679 INNADLGDTANYTCVASNIAGKTTREF-----ILTVNVPPNIKGG--------------P 3719

Query: 234  TSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
             S  ++   + VL+C+A G P P   W K+
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWRKD 3749



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 40/206 (19%), Positives = 63/206 (30%), Gaps = 51/206 (24%)

Query: 124  PPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTS---------E 174
            PP I  +       V+ G  + L C ++G P     W K    +   +           +
Sbjct: 2194 PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQ 2253

Query: 175  LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVS--ESKLQICVE 232
            L  +     DA  Y C  +N                        V G +  E  LQ+ + 
Sbjct: 2254 LQISIAEKSDAALYSCVASN------------------------VAGTAKKEYNLQVYIR 2289

Query: 233  PTSQK---------LMPGSTLVLQCVAVGSPIPHYQWFKNELPLTH-------ETKKLYM 276
            PT            +  G ++ L+C   G P P   W K+  PL         +   +  
Sbjct: 2290 PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQ 2349

Query: 277  VPYVDLEHQGTYWCHVYNDRDSQDSK 302
            +  + +   G Y C   N     D K
Sbjct: 2350 LKNIHVSDTGRYVCVAVNVAGMTDKK 2375


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
           isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/151 (27%), Positives = 67/151 (44%), Gaps = 21/151 (13%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSELIFNAVHVK- 183
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L   A+ ++ 
Sbjct: 137 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIES 196

Query: 184 ----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
               D G Y C   N+    +S  + L V             V     +  + P S ++M
Sbjct: 197 SEETDQGKYECVATNSAGVRYSSPANLYV------------RVRRVAPRFSILPMSHEIM 244

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           PG  + + CVAVGSP+P+ +W +    LT E
Sbjct: 245 PGGNVNITCVAVGSPMPYVKWMQGAEDLTPE 275



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 37/149 (24%), Positives = 61/149 (40%), Gaps = 26/149 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV-----------H 181
           P+ +  ++G      C+ATG P  +  W K  K++ +     + F+              
Sbjct: 39  PKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT 98

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C V  N   E +  ++L V     +P  F  ++D   + K+   VE T    
Sbjct: 99  PRDENVYEC-VAQNSVGEITVHAKLTVLREDQLPSGFP-NIDMGPQLKV---VERT---- 149

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
               T  + C A G+P P   WFK+ LP+
Sbjct: 150 ---RTATMLCAASGNPDPEITWFKDFLPV 175


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
           isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/151 (27%), Positives = 67/151 (44%), Gaps = 21/151 (13%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSELIFNAVHVK- 183
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L   A+ ++ 
Sbjct: 137 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIES 196

Query: 184 ----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
               D G Y C   N+    +S  + L V             V     +  + P S ++M
Sbjct: 197 SEETDQGKYECVATNSAGVRYSSPANLYV------------RVRRVAPRFSILPMSHEIM 244

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           PG  + + CVAVGSP+P+ +W +    LT E
Sbjct: 245 PGGNVNITCVAVGSPMPYVKWMQGAEDLTPE 275



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 37/149 (24%), Positives = 61/149 (40%), Gaps = 26/149 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV-----------H 181
           P+ +  ++G      C+ATG P  +  W K  K++ +     + F+              
Sbjct: 39  PKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT 98

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C V  N   E +  ++L V     +P  F  ++D   + K+   VE T    
Sbjct: 99  PRDENVYEC-VAQNSVGEITVHAKLTVLREDQLPSGFP-NIDMGPQLKV---VERT---- 149

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
               T  + C A G+P P   WFK+ LP+
Sbjct: 150 ---RTATMLCAASGNPDPEITWFKDFLPV 175


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
           2 precursor [Homo sapiens]
          Length = 1899

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/151 (27%), Positives = 68/151 (45%), Gaps = 21/151 (13%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSELIFNAVHVK- 183
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L   A+ ++ 
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQ 187

Query: 184 ----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
               D G Y C   N+    +S  + L V             V     +  + PT+ ++M
Sbjct: 188 SEESDQGKYECVATNSAGTRYSAPANLYV------------RVRRVPPRFSIPPTNHEIM 235

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           PG ++ + CVAVGSP+P+ +W      LT E
Sbjct: 236 PGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 266



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 28/159 (17%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN----------GNT 172
           +PP  + T  P  +  ++G      C+ATG P  +  W K  K++ N          G+ 
Sbjct: 22  TPP--RFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 173 SELIFNAVHV-KDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQ 228
           S L    +   +D   Y C  +NN   E S  ++L V     IP  F  ++D   + K+ 
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFP-TIDMGPQLKV- 136

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             VE T        T  + C A G+P P   WFK+ LP+
Sbjct: 137 --VERT-------RTATMLCAASGNPDPEITWFKDFLPV 166


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
           sapiens]
          Length = 2113

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 49/186 (26%), Positives = 78/186 (41%), Gaps = 31/186 (16%)

Query: 135 SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT-----SELIFNAVHVKDAGFYV 189
           S+ V AG  V+L C A+G+P    +W K  + +P  +      + L  + +  +D+G Y+
Sbjct: 294 SQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYI 353

Query: 190 CRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCV 249
           C V N F         L V D                L + + P   K   GST++L C 
Sbjct: 354 CEVTNTFG-SAEATGILMVID---------------PLHVTLTPKKLKTGIGSTVILSCA 397

Query: 250 AVGSPIPHYQWFKN-ELPLTHE-------TKKLYMVPYVDLEHQGTYWCHVYNDRDSQDS 301
             GSP    +W++N EL L  E       + +  ++      H G Y C  +  R +Q +
Sbjct: 398 LTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC--FATRKAQTA 455

Query: 302 KKVEII 307
           +   II
Sbjct: 456 QDFAII 461



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/146 (30%), Positives = 68/146 (46%), Gaps = 19/146 (13%)

Query: 175 LIFNAVHVKDA-GFYVCRVNNNFTFEFSQ--WSQLDVCDIPESFQRSVDGVSESKLQICV 231
           L  + V  +DA   Y C   + ++ E  Q   ++L V D  ES    +DG          
Sbjct: 242 LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFH-------- 293

Query: 232 EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE---TKKLYMVPYVDL--EHQG 286
              SQ++  G T+ L C A G PIP  +W K+  PL  +   TK++  +   DL  E  G
Sbjct: 294 ---SQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSG 350

Query: 287 TYWCHVYNDRDSQDSKKVEIIIDELN 312
           TY C V N   S ++  + ++ID L+
Sbjct: 351 TYICEVTNTFGSAEATGILMVIDPLH 376



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 42/200 (21%), Positives = 76/200 (38%), Gaps = 31/200 (15%)

Query: 98  EKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQ 157
           + G  + E+++   + E T +L ++ P  + +T+ P+      G  V L C  TG P   
Sbjct: 348 DSGTYICEVTNTFGSAEATGILMVIDP--LHVTLTPKKLKTGIGSTVILSCALTGSPEFT 405

Query: 158 YQWFKMNK--------EIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQ-LDV 208
            +W++  +         I   +   L+  +     +G Y C     F    +Q +Q   +
Sbjct: 406 IRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC-----FATRKAQTAQDFAI 460

Query: 209 CDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL- 267
             + +   R V   SE  +            PG    L C A G+P P   W  ++ P+ 
Sbjct: 461 IALEDGTPRIVSSFSEKVVN-----------PGEQFSLMCAAKGAPPPTVTWALDDEPIV 509

Query: 268 ---THETKKLYMVPYVDLEH 284
              +H T +  M     + H
Sbjct: 510 RDGSHRTNQYTMSDGTTISH 529



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 47/213 (22%), Positives = 80/213 (37%), Gaps = 43/213 (20%)

Query: 101 CTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQW 160
           CT   L   + + E+   + +  PP I+   N  +   +AG+   + CR  G+P+   +W
Sbjct: 545 CTARNL---VGSAEYQARINVRGPPSIRAMRNITA---VAGRDTLINCRVIGYPYYSIKW 598

Query: 161 FKMNKEIPNGNTSELIFNAVHVK--------DAGFYVCRVNNNFTFEFSQWSQLDVCDIP 212
           +K    +P+ N  +++F    +K        D G Y+C V        SQ   + V    
Sbjct: 599 YKDALLLPD-NHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAV---- 653

Query: 213 ESFQRSVDGVSESKLQICVEPTS-QKLMPGSTLVLQCVAVGSPIP-HYQWFKNELPL--- 267
                        K+   ++P        G  L + CV     +P    W K+   +   
Sbjct: 654 -------------KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISG 700

Query: 268 ---THETKKL---YMVPYVDLEHQGTYWCHVYN 294
              T E+K+      +  V L+H G Y C   N
Sbjct: 701 SGVTIESKEFMSSLQISSVSLKHNGNYTCIASN 733



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 10/66 (15%)

Query: 144  VKLCCRATGHPFVQYQWFKMNKE--IPNG--------NTSELIFNAVHVKDAGFYVCRVN 193
            V+L C + G P    +W K +++  IP              L+  AV  +D+G+Y C   
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426

Query: 194  NNFTFE 199
            N   F+
Sbjct: 1427 NTGGFD 1432



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 42/185 (22%), Positives = 70/185 (37%), Gaps = 39/185 (21%)

Query: 147 CCRATGHPFVQYQWFKMNKEIPNGN---------TSELIFNAVHVKDAGFYVCRVNNNFT 197
           C  ++G   ++  W K  + I +G+          S L  ++V +K  G Y C + +N  
Sbjct: 677 CVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTC-IASNAA 735

Query: 198 FEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPH 257
              S+  QL +  +P  F               V+P +Q  + G   VL C   G P P 
Sbjct: 736 ATVSRERQL-IVRVPPRF--------------VVQPNNQDGIYGKAGVLNCSVDGYPPPK 780

Query: 258 YQWFK----------NELPLTHETKKL----YMVPYVDLEHQGTYWCHVYNDRDSQDSKK 303
             W            + +PLT   + L     ++ +V  E  G Y C   N   +  SK 
Sbjct: 781 VMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKS 840

Query: 304 VEIII 308
           + + +
Sbjct: 841 MFLTV 845


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
           5 precursor [Homo sapiens]
          Length = 1502

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 72/157 (45%), Gaps = 23/157 (14%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSEL------IFN 178
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L      I  
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRG 187

Query: 179 AVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
           A+ ++     D G Y C   N+    +S  + L V ++ E        V     +  + P
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE--------VRRVPPRFSIPP 239

Query: 234 TSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           T+ ++MPG ++ + CVAVGSP+P+ +W      LT E
Sbjct: 240 TNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 276



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 53/221 (23%), Positives = 84/221 (38%), Gaps = 43/221 (19%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN----------GNT 172
           +PP  + T  P  +  ++G      C+ATG P  +  W K  K++ N          G+ 
Sbjct: 22  TPP--RFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 173 SELIFNAVHV-KDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQ 228
           S L    +   +D   Y C  +NN   E S  ++L V     IP  F  ++D   + K+ 
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFP-TIDMGPQLKV- 136

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHET---------------KK 273
             VE T        T  + C A G+P P   WFK+ LP+                   + 
Sbjct: 137 --VERT-------RTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRG 187

Query: 274 LYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNL 314
              +   +   QG Y C   N   ++ S    + + EL  +
Sbjct: 188 ALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREV 228


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 52/178 (29%), Positives = 76/178 (42%), Gaps = 27/178 (15%)

Query: 128 KITVN-PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG-----NTSELIFNAVH 181
           KI V+ P +     G  VK+ C A G+P     W K+N  IP+      + + L    V 
Sbjct: 301 KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ 360

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 241
           + DAG Y CR  N+   + S   QL V   P   ++  D   +S               G
Sbjct: 361 LDDAGIYECRAENS-RGKNSFRGQLQVYTYPHWVEKLNDTQLDS---------------G 404

Query: 242 STLVLQCVAVGSPIPHYQWFKNELPLTHETK-----KLYMVPYVDLEHQGTYWCHVYN 294
           S L  +C A G P P Y+W KN +PL+ +++      + M+  V+    G Y C   N
Sbjct: 405 SPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAEN 462



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 47/178 (26%), Positives = 71/178 (39%), Gaps = 26/178 (14%)

Query: 137 AVLAGQFVKLCCRATGH-PFVQYQWF---------KMNKEIPNGNTSELIFNAVHVKDAG 186
           +V  GQ V L C    H P + Y W          + ++   +  T  L  + V   D G
Sbjct: 206 SVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVG 265

Query: 187 FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVS---ESKLQICVEPTSQKLMPGST 243
            Y+C V N  T          V   P       DGV    E K+++   P +     G+T
Sbjct: 266 SYICLVKNTVT-------NARVLSPPTPLTLRNDGVMGEYEPKIEVHF-PFTVTAAKGTT 317

Query: 244 LVLQCVAVGSPIPHYQWFK--NELPLTHETKK---LYMVPYVDLEHQGTYWCHVYNDR 296
           + ++C A+G+P+P   W K    +P     +K   +  +P V L+  G Y C   N R
Sbjct: 318 VKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSR 375



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/174 (25%), Positives = 62/174 (35%), Gaps = 42/174 (24%)

Query: 144 VKLCCRATGHPFVQYQWFKMNKEIPNGNT--------SELIFNAVHVKDAGFYVCRVNNN 195
           V L C   G+P   Y+W +   EI   +         + +I N    KD+G Y C   N 
Sbjct: 119 VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNT 178

Query: 196 FTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPI 255
                S+ + L    +     R+   VS              +  G  +VL C    SP 
Sbjct: 179 VGSILSREATLQFAYLGNFSGRTRSAVS--------------VREGQGVVLMC----SPP 220

Query: 256 PH-----YQWFKNELP----------LTHETKKLYMVPYVDLEHQGTYWCHVYN 294
           PH     Y W  NE P          ++ ET  LY +  V     G+Y C V N
Sbjct: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLY-ISKVQTSDVGSYICLVKN 273



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 19/136 (13%)

Query: 148 CRATGHPFVQYQWFKMNKEIPNGNTSELI-----FNAVHVKDAGFYVCRVNNNFTFEFSQ 202
           C+ATG P   Y+W K    +   +  E++      + V+  DAG Y C   N +   ++ 
Sbjct: 411 CKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS 470

Query: 203 WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK 262
            ++L +     +F      +++ K  I V    +       +V++C   GSP P   W K
Sbjct: 471 -AELKILASAPTF-----ALNQLKKTIIVTKDQE-------VVIECKPQGSPKPTISWKK 517

Query: 263 NELPLTHETKKLYMVP 278
            +  +  E K++ ++P
Sbjct: 518 GDRAV-RENKRIAILP 532



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 50/216 (23%), Positives = 79/216 (36%), Gaps = 44/216 (20%)

Query: 117 EVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI--------- 167
           E+  L S P   +    ++  V   Q V + C+  G P     W K ++ +         
Sbjct: 472 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL 531

Query: 168 PNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
           P+G+    I NA    D G YVCR  N F             +I  S         +   
Sbjct: 532 PDGSLR--ILNASK-SDEGKYVCRGENVF----------GSAEIIASLS------VKEPT 572

Query: 228 QICVEPTSQKLMPGSTLVLQCVAV--GSPIPHYQWFKNELPLTHETKKLY---------- 275
           +I + P   +L  G ++VL C A+   S    + W     P+  E +  +          
Sbjct: 573 RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 632

Query: 276 ---MVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIII 308
              M+  + L H G Y C V    DS  S + E+++
Sbjct: 633 ADLMIRNILLMHAGRYGCRVQTTADSV-SDEAELLV 667


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 52/178 (29%), Positives = 76/178 (42%), Gaps = 27/178 (15%)

Query: 128 KITVN-PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG-----NTSELIFNAVH 181
           KI V+ P +     G  VK+ C A G+P     W K+N  IP+      + + L    V 
Sbjct: 227 KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ 286

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 241
           + DAG Y CR  N+   + S   QL V   P   ++  D   +S               G
Sbjct: 287 LDDAGIYECRAENS-RGKNSFRGQLQVYTYPHWVEKLNDTQLDS---------------G 330

Query: 242 STLVLQCVAVGSPIPHYQWFKNELPLTHETK-----KLYMVPYVDLEHQGTYWCHVYN 294
           S L  +C A G P P Y+W KN +PL+ +++      + M+  V+    G Y C   N
Sbjct: 331 SPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAEN 388



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 47/178 (26%), Positives = 71/178 (39%), Gaps = 26/178 (14%)

Query: 137 AVLAGQFVKLCCRATGH-PFVQYQWF---------KMNKEIPNGNTSELIFNAVHVKDAG 186
           +V  GQ V L C    H P + Y W          + ++   +  T  L  + V   D G
Sbjct: 132 SVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVG 191

Query: 187 FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVS---ESKLQICVEPTSQKLMPGST 243
            Y+C V N  T          V   P       DGV    E K+++   P +     G+T
Sbjct: 192 SYICLVKNTVT-------NARVLSPPTPLTLRNDGVMGEYEPKIEVHF-PFTVTAAKGTT 243

Query: 244 LVLQCVAVGSPIPHYQWFK--NELPLTHETKK---LYMVPYVDLEHQGTYWCHVYNDR 296
           + ++C A+G+P+P   W K    +P     +K   +  +P V L+  G Y C   N R
Sbjct: 244 VKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSR 301



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/174 (25%), Positives = 62/174 (35%), Gaps = 42/174 (24%)

Query: 144 VKLCCRATGHPFVQYQWFKMNKEIPNGNT--------SELIFNAVHVKDAGFYVCRVNNN 195
           V L C   G+P   Y+W +   EI   +         + +I N    KD+G Y C   N 
Sbjct: 45  VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNT 104

Query: 196 FTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPI 255
                S+ + L    +     R+   VS              +  G  +VL C    SP 
Sbjct: 105 VGSILSREATLQFAYLGNFSGRTRSAVS--------------VREGQGVVLMC----SPP 146

Query: 256 PH-----YQWFKNELP----------LTHETKKLYMVPYVDLEHQGTYWCHVYN 294
           PH     Y W  NE P          ++ ET  LY +  V     G+Y C V N
Sbjct: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLY-ISKVQTSDVGSYICLVKN 199



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/136 (23%), Positives = 60/136 (44%), Gaps = 19/136 (13%)

Query: 148 CRATGHPFVQYQWFKMNKEIPNGNTSELI-----FNAVHVKDAGFYVCRVNNNFTFEFSQ 202
           C+ATG P   Y+W K    +   +  E++      + V+  DAG Y C   N +   ++ 
Sbjct: 337 CKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS 396

Query: 203 WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK 262
            ++L +     +F      +++ K  I V    +       +V++C   GSP P   W K
Sbjct: 397 -AELKILASAPTF-----ALNQLKKTIIVTKDQE-------VVIECKPQGSPKPTISWKK 443

Query: 263 NELPLTHETKKLYMVP 278
            +  +  E K++ ++P
Sbjct: 444 GDRAV-RENKRIAILP 458



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 50/216 (23%), Positives = 79/216 (36%), Gaps = 44/216 (20%)

Query: 117 EVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI--------- 167
           E+  L S P   +    ++  V   Q V + C+  G P     W K ++ +         
Sbjct: 398 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAIL 457

Query: 168 PNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
           P+G+    I NA    D G YVCR  N F             +I  S         +   
Sbjct: 458 PDGSLR--ILNASK-SDEGKYVCRGENVF----------GSAEIIASLS------VKEPT 498

Query: 228 QICVEPTSQKLMPGSTLVLQCVAV--GSPIPHYQWFKNELPLTHETKKLY---------- 275
           +I + P   +L  G ++VL C A+   S    + W     P+  E +  +          
Sbjct: 499 RIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASS 558

Query: 276 ---MVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIII 308
              M+  + L H G Y C V    DS  S + E+++
Sbjct: 559 ADLMIRNILLMHAGRYGCRVQTTADSV-SDEAELLV 593


>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
           sapiens]
          Length = 602

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 44/170 (25%), Positives = 71/170 (41%), Gaps = 9/170 (5%)

Query: 138 VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN-----TSELIFNAVHVKDAGFYVCRV 192
           V  GQF++L C A   P     W   ++ + + +     T  L    V   D+G Y CR 
Sbjct: 277 VQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRA 336

Query: 193 NNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVG 252
            N    +  Q   L V   PE+ +  V   + + L+     TS  ++ G +L L CV   
Sbjct: 337 ENRLGSQ-QQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHS 395

Query: 253 SP---IPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQ 299
           SP   +   +W +   P       +  +P + +EH+G + CH  +   SQ
Sbjct: 396 SPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445


>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
           sapiens]
          Length = 698

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 44/170 (25%), Positives = 71/170 (41%), Gaps = 9/170 (5%)

Query: 138 VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN-----TSELIFNAVHVKDAGFYVCRV 192
           V  GQF++L C A   P     W   ++ + + +     T  L    V   D+G Y CR 
Sbjct: 277 VQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRA 336

Query: 193 NNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVG 252
            N    +  Q   L V   PE+ +  V   + + L+     TS  ++ G +L L CV   
Sbjct: 337 ENRLGSQ-QQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHS 395

Query: 253 SP---IPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQ 299
           SP   +   +W +   P       +  +P + +EH+G + CH  +   SQ
Sbjct: 396 SPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQ 445


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
           isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 43/160 (26%), Positives = 71/160 (44%), Gaps = 26/160 (16%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSEL--------- 175
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L         
Sbjct: 137 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTP 196

Query: 176 IFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
           I  A+ ++     D G Y C   N+    +S  + L V ++ E        V     +  
Sbjct: 197 IRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELRE--------VRRVAPRFS 248

Query: 231 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           + P S ++MPG  + + CVAVGSP+P+ +W +    LT E
Sbjct: 249 ILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPE 288



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 37/149 (24%), Positives = 61/149 (40%), Gaps = 26/149 (17%)

Query: 133 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV-----------H 181
           P+ +  ++G      C+ATG P  +  W K  K++ +     + F+              
Sbjct: 39  PKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT 98

Query: 182 VKDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQICVEPTSQKL 238
            +D   Y C V  N   E +  ++L V     +P  F  ++D   + K+   VE T    
Sbjct: 99  PRDENVYEC-VAQNSVGEITVHAKLTVLREDQLPSGFP-NIDMGPQLKV---VERT---- 149

Query: 239 MPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
               T  + C A G+P P   WFK+ LP+
Sbjct: 150 ---RTATMLCAASGNPDPEITWFKDFLPV 175


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 50/193 (25%), Positives = 75/193 (38%), Gaps = 35/193 (18%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKE----------IPNGNT 172
           SP      + P++  VL G+ V L C ATGHP  +  W + ++            P+G  
Sbjct: 338 SPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG- 396

Query: 173 SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVE 232
             L    V   D+G Y C   NN                 +S   +   + ++  Q  V 
Sbjct: 397 --LYIQNVVQGDSGEYACSATNNI----------------DSVHATAFIIVQALPQFTVT 438

Query: 233 PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM------VPYVDLEHQG 286
           P  + ++ G T+  QC A G+P P   W K    L+ + + L +      +  V L  QG
Sbjct: 439 PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQG 498

Query: 287 TYWCHVYNDRDSQ 299
            Y C   N   SQ
Sbjct: 499 QYECQAVNIIGSQ 511



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 42/186 (22%), Positives = 68/186 (36%), Gaps = 27/186 (14%)

Query: 128 KITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSE--------LIFNA 179
           +IT  P+   V +G  V   CRA G+P  +  W + N E+     S         L+   
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQN 306

Query: 180 VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
               D G Y C   N      +Q   L     P            ++    ++P + +++
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP------------ARPTFVIQPQNTEVL 354

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQ-------GTYWCHV 292
            G ++ L+C A G P P   W + +        ++ + P   L  Q       G Y C  
Sbjct: 355 VGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSA 414

Query: 293 YNDRDS 298
            N+ DS
Sbjct: 415 TNNIDS 420



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 48/188 (25%), Positives = 77/188 (40%), Gaps = 26/188 (13%)

Query: 97  GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFV 156
           GE  C+ T   D + A     ++Q L     + TV P+ + V+ GQ V   C A G+P  
Sbjct: 408 GEYACSATNNIDSVHATAFI-IVQALP----QFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462

Query: 157 QYQWFKMNKEIPNG------NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCD 210
              W K   ++         ++  L  + V + D G Y C+  N         SQ  V  
Sbjct: 463 VIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG------SQKVVAH 516

Query: 211 IPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           +  + Q  V  V  S       P+   +  G+ + L C + G P P   W K+ + +T E
Sbjct: 517 L--TVQPRVTPVFASI------PSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-E 567

Query: 271 TKKLYMVP 278
           + K ++ P
Sbjct: 568 SGKFHISP 575


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
           precursor [Homo sapiens]
          Length = 1912

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 72/160 (45%), Gaps = 26/160 (16%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSEL--------- 175
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L         
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTP 187

Query: 176 IFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
           I  A+ ++     D G Y C   N+    +S  + L V ++ E        V     +  
Sbjct: 188 IRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE--------VRRVPPRFS 239

Query: 231 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           + PT+ ++MPG ++ + CVAVGSP+P+ +W      LT E
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 279



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 28/159 (17%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN----------GNT 172
           +PP  + T  P  +  ++G      C+ATG P  +  W K  K++ N          G+ 
Sbjct: 22  TPP--RFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 173 SELIFNAVHV-KDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQ 228
           S L    +   +D   Y C  +NN   E S  ++L V     IP  F  ++D   + K+ 
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFP-TIDMGPQLKV- 136

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             VE T        T  + C A G+P P   WFK+ LP+
Sbjct: 137 --VERT-------RTATMLCAASGNPDPEITWFKDFLPV 166


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
           3 precursor [Homo sapiens]
          Length = 1903

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 72/160 (45%), Gaps = 26/160 (16%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSEL--------- 175
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L         
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTP 187

Query: 176 IFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
           I  A+ ++     D G Y C   N+    +S  + L V ++ E        V     +  
Sbjct: 188 IRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE--------VRRVPPRFS 239

Query: 231 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           + PT+ ++MPG ++ + CVAVGSP+P+ +W      LT E
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 279



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 28/159 (17%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN----------GNT 172
           +PP  + T  P  +  ++G      C+ATG P  +  W K  K++ N          G+ 
Sbjct: 22  TPP--RFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 173 SELIFNAVHV-KDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQ 228
           S L    +   +D   Y C  +NN   E S  ++L V     IP  F  ++D   + K+ 
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFP-TIDMGPQLKV- 136

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             VE T        T  + C A G+P P   WFK+ LP+
Sbjct: 137 --VERT-------RTATMLCAASGNPDPEITWFKDFLPV 166


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
           4 precursor [Homo sapiens]
          Length = 1501

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 43/160 (26%), Positives = 72/160 (45%), Gaps = 26/160 (16%)

Query: 129 ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK----MNKEIPNGNTSEL--------- 175
           I + P+ K V   +   + C A+G+P  +  WFK    ++    NG   +L         
Sbjct: 128 IDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTP 187

Query: 176 IFNAVHVK-----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
           I  A+ ++     D G Y C   N+    +S  + L V ++ E        V     +  
Sbjct: 188 IRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELRE--------VRRVPPRFS 239

Query: 231 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHE 270
           + PT+ ++MPG ++ + CVAVGSP+P+ +W      LT E
Sbjct: 240 IPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 279



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 28/159 (17%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN----------GNT 172
           +PP  + T  P  +  ++G      C+ATG P  +  W K  K++ N          G+ 
Sbjct: 22  TPP--RFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 173 SELIFNAVHV-KDAGFYVCRVNNNFTFEFSQWSQLDVC---DIPESFQRSVDGVSESKLQ 228
           S L    +   +D   Y C  +NN   E S  ++L V     IP  F  ++D   + K+ 
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFP-TIDMGPQLKV- 136

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
             VE T        T  + C A G+P P   WFK+ LP+
Sbjct: 137 --VERT-------RTATMLCAASGNPDPEITWFKDFLPV 166


>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
          Length = 697

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 43/167 (25%), Positives = 68/167 (40%), Gaps = 9/167 (5%)

Query: 141 GQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT-----SELIFNAVHVKDAGFYVCRVNNN 195
           GQF++L C A   P     W   N+ + + +        L    V   D+G Y CR  N 
Sbjct: 269 GQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENR 328

Query: 196 FTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPI 255
              +  +   L V   PE+ +  V   + + L+     TS  ++ G +L L CV   SP 
Sbjct: 329 LGSQ-QRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPP 387

Query: 256 PHYQWFKNELPLTHETKK---LYMVPYVDLEHQGTYWCHVYNDRDSQ 299
               W +    L+        +  +P V +EH+G + CH  +   SQ
Sbjct: 388 ARLSWTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQ 434


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 57/242 (23%), Positives = 92/242 (38%), Gaps = 36/242 (14%)

Query: 85   EGSPSLCLLKL-MGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQF 143
            EG+ SL ++++ M + G      ++ + + + +  L +  PP       P SK VL G  
Sbjct: 4165 EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSF--VTKPGSKDVLPGSA 4222

Query: 144  VKLCCRATGHPFVQYQWFKMNKEIPNGNT---------SELIFNAVHVKDAGFYVCRVNN 194
            V L     G   +  +WFK NKE+ +G +         S L    V   D+G Y C+V+N
Sbjct: 4223 VCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSN 4282

Query: 195  NFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSP 254
                   + S       P +F   ++              SQ L  G    L C   G+P
Sbjct: 4283 --VAGGVECSANLFVKEPATFVEKLE-------------PSQLLKKGDATQLACKVTGTP 4327

Query: 255  IPHYQWFKNELPLTHETK---------KLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVE 305
                 WF N+  +   +K          +  +  V +E  G Y C   N+  S     + 
Sbjct: 4328 PIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIV 4387

Query: 306  II 307
            I+
Sbjct: 4388 IV 4389



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 48/189 (25%), Positives = 78/189 (41%), Gaps = 26/189 (13%)

Query: 93   LKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATG 152
            L  + + G  V   S+   +   +  + +  PP     V+P S  +L G+  +L C+  G
Sbjct: 3705 LAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDP-SYLMLPGESARLHCKLKG 3763

Query: 153  HPFVQYQWFKMNKEIPNGNTSELIF---------NAVHVKDAGFYVCRVNNNFTFEFSQW 203
             P +Q  WFK NKE+   NT  + F           V V+D+G Y C   N+   +    
Sbjct: 3764 SPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSD--SC 3821

Query: 204  SQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
            S   V   P SF ++            +EP    ++ G+  +LQC   G+      WFK+
Sbjct: 3822 STEIVIKEPPSFIKT------------LEPAD--IVRGTNALLQCEVSGTGPFEISWFKD 3867

Query: 264  ELPLTHETK 272
            +  +    K
Sbjct: 3868 KKQIRSSKK 3876



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 50/183 (27%), Positives = 76/183 (41%), Gaps = 35/183 (19%)

Query: 131  VNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGN-TSELIFNAVHVK----- 183
            + P S  V+AG+     C  TG   ++  W K NKEI P GN T   + N  H++     
Sbjct: 6275 IKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVG 6334

Query: 184  --DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 241
              D+G Y C+  N+   +    +QL V + P  F + ++    +K              G
Sbjct: 6335 KGDSGQYTCQATNDVGKDMCS-AQLSVKE-PPKFVKKLEASKVAK-------------QG 6379

Query: 242  STLVLQCVAVGSPIPHYQWFKNELPLTHETKK----------LYMVPYVDLEHQGTYWCH 291
             ++ L+C   GSP     WF+N+  L HE+ K          L  +     E  G Y C 
Sbjct: 6380 ESIQLECKISGSPEIKVSWFRNDSEL-HESWKYNMSFINSVALLTINEASAEDSGDYICE 6438

Query: 292  VYN 294
             +N
Sbjct: 6439 AHN 6441



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 52/214 (24%), Positives = 82/214 (38%), Gaps = 37/214 (17%)

Query: 115  HTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSE 174
            +  VL    PP     +    K +  G  + + C+ +G   +  QWFK  KEI       
Sbjct: 5227 YLRVLDQNIPPSFTKKLTKMDKVL--GSSIHMECKVSGSLPISAQWFKDGKEISTSAKYR 5284

Query: 175  LI---------FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSES 225
            L+          N + ++D   Y C+V+N         S +     P SF          
Sbjct: 5285 LVCHERSVSLEVNNLELEDTANYTCKVSN--VAGDDACSGILTVKEPPSF---------- 5332

Query: 226  KLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---------KLYM 276
                 V+P  Q+ +P ST+  + +  G+P    +WFK+++ L    K             
Sbjct: 5333 ----LVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLN 5388

Query: 277  VPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDE 310
            +  VD    G Y CHV ND  S DS    +++ E
Sbjct: 5389 LYSVDASKTGQYTCHVTNDVGS-DSCTTMLLVTE 5421



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 45/192 (23%), Positives = 83/192 (43%), Gaps = 21/192 (10%)

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN---------TSELIFNAVHVKDAGFY 188
            V  G++V+L C   G   ++ QW K  +EI   +         T+ L    V   D+G Y
Sbjct: 8357 VSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDY 8416

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
            VC+ +N    + ++ S++ + D P     +     + +L    EP S +++  +T     
Sbjct: 8417 VCKASNVAGSDTTK-SKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIA 8475

Query: 249  VAVGSPIPHYQWFKNELPLTHETKKLYMVPYVD---LE-------HQGTYWCHVYNDRDS 298
               G PIP+ +W K +    ++  ++++    D   LE         G Y C  +N+   
Sbjct: 8476 KVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE 8535

Query: 299  QDSKKVEIIIDE 310
             +S  V + +DE
Sbjct: 8536 IES-NVNLQVDE 8546



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 43/196 (21%), Positives = 73/196 (37%), Gaps = 35/196 (17%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP--------- 168
            ++  L PP     + P   AV  G  V L C+  G P +   W+K + ++          
Sbjct: 6072 LVSTLEPPYFVTELEPLEAAV--GDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYF 6129

Query: 169  NGNTSELIFNAVHVKDAGFYVCRVNNNF-TFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
              N + L+FN V++ D+G Y C+  N+  T       ++    +P SF R +  + ++  
Sbjct: 6130 TNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT-- 6187

Query: 228  QICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---------KLYMVP 278
                         G  + L C   GS      W+++ + L  +               + 
Sbjct: 6188 ------------VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKIL 6235

Query: 279  YVDLEHQGTYWCHVYN 294
              DL H G Y C   N
Sbjct: 6236 QTDLSHSGQYSCSASN 6251



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 41/158 (25%), Positives = 65/158 (41%), Gaps = 28/158 (17%)

Query: 121  LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP---------NGN 171
            +L PP     + P   +V  G    L C+  G P +   W+K + ++            N
Sbjct: 7957 ILEPPYFVKQLEPVKVSV--GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNN 8014

Query: 172  TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCD--IPESFQRSVDGVSESKLQI 229
             + L+FN V + D+G Y+C+  N+   E S  + L V +  +P SF R +  V E+    
Sbjct: 8015 VATLVFNQVDINDSGEYICKAENS-VGEVSASTFLTVQEQKLPPSFSRQLRDVQET---- 8069

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
                       G  +V  C   GS      W+K+  PL
Sbjct: 8070 ----------VGLPVVFDCAISGSEPISVSWYKDGKPL 8097



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 52/251 (20%), Positives = 91/251 (36%), Gaps = 39/251 (15%)

Query: 83   EPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEV-----LQLLSPPGIKITVNPESKA 137
            E EG+ +      +G+   T     +  +++ H  +     +++ + P IK  + P   A
Sbjct: 3409 EDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVA 3468

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN---------TSELIFNAVHVKDAGFY 188
            +  G   K  C     P V++QWFK  +EI   +          S L      V D G Y
Sbjct: 3469 L--GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEY 3526

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
             C+ +N    E+   S      + E++  +              P S     G      C
Sbjct: 3527 TCKASN----EYGSVSCTATLTVTEAYPPT----------FLSRPKSLTTFVGKAAKFIC 3572

Query: 249  VAVGSPIPHYQWFKNELPLT---------HETKKLYMVPYVDLEHQGTYWCHVYNDRDSQ 299
               G+P+    W K+   L+          E K +  +  + ++ +G Y C   N   + 
Sbjct: 3573 TVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGAD 3632

Query: 300  DSKKVEIIIDE 310
              +   IIID+
Sbjct: 3633 ICQAELIIIDK 3643



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 55/203 (27%), Positives = 77/203 (37%), Gaps = 39/203 (19%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL-IF 177
            L +L P    I   PES  V  G    L C   G P +  +WFK  KE+ + N  ++  F
Sbjct: 7580 LSVLEPA--TIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFF 7637

Query: 178  NAVH--------VKDAGFYVCRVNNNFTFEFSQWSQLDVCD--IPESFQRSVDGVSESKL 227
            N V           D+G Y   V N    + S  + L V D  +P SF R +   +    
Sbjct: 7638 NKVSGLKIINVAPSDSGVYSFEVQNPVGKD-SCTASLQVSDRTVPPSFTRKLKETNG--- 7693

Query: 228  QICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWF----------KNELPLTHETKKLYMV 277
                       + GS++V++C   GSP     WF          K +  LT  T  L  V
Sbjct: 7694 -----------LSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCAL-TV 7741

Query: 278  PYVDLEHQGTYWCHVYNDRDSQD 300
              ++    G Y C   N   S +
Sbjct: 7742 NMLEESDSGDYTCIATNMAGSDE 7764



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 43/202 (21%), Positives = 76/202 (37%), Gaps = 48/202 (23%)

Query: 124  PPGIKITVNP-------ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI 176
            P  ++I V P       ++  V+ G+ V L C  +G+P     W++ + +I +    ++ 
Sbjct: 933  PAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQIT 992

Query: 177  FNA---------VHVKDAGFYVCRVNNN---------FTFEFSQWSQLDVCDIPESFQRS 218
            F +            +D+G + C   N             + S+  + +   + E F   
Sbjct: 993  FQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTE 1052

Query: 219  VDGVSESKLQICVE---------------------PTSQKLMPGSTLVLQCVAVGSPIPH 257
                 ES+  +  +                     P  QKL+ G ++V  C   G+P PH
Sbjct: 1053 EKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPH 1112

Query: 258  YQWFKNELPLTHETKKLYMVPY 279
              W K+ +PLT  T   Y V Y
Sbjct: 1113 VYWKKSGVPLT--TGYRYKVSY 1132



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 52/230 (22%), Positives = 90/230 (39%), Gaps = 36/230 (15%)

Query: 85   EGSPSLCLLKL-MGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQF 143
            E + +L +LK+  G+ G      S+       +  L +  PP     + P S+ V   +F
Sbjct: 7264 ENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEP-SRIVKQDEF 7322

Query: 144  VKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF---------NAVHVKDAGFYVCRVNN 194
             +  C+  G P ++  W+K   EI   +   + F         + + V+D+G Y C   +
Sbjct: 7323 TRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEA-H 7381

Query: 195  NFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSP 254
            N     S  + L V + P  F++              +P   + + G+ + L+C   G+P
Sbjct: 7382 NAAGSASSSTSLKVKE-PPIFRK--------------KPHPIETLKGADVHLECELQGTP 7426

Query: 255  IPHYQWFKNELPLTHETKKLYM---------VPYVDLEHQGTYWCHVYND 295
              H  W+K++  L    K   M         +  VD    G Y C   ND
Sbjct: 7427 PFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATND 7476



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 49/206 (23%), Positives = 77/206 (37%), Gaps = 42/206 (20%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP--------- 168
            VL L+ PP    T   +    + G F+ L C   G   +  QWFK ++EI          
Sbjct: 4668 VLDLIIPPSF--TKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSF 4725

Query: 169  NGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
            + NT+ L  + +   D+G Y C   N           L V + P   ++           
Sbjct: 4726 HDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCS-GHLTVKEPPYFVEK----------- 4773

Query: 229  ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL------------THETKKLYM 276
                P SQ + P + + L+ +  G+     +WFK+   L            T  + +L+ 
Sbjct: 4774 ----PQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFA 4829

Query: 277  VPYVDLEHQGTYWCHVYNDRDSQDSK 302
                D    GTY C + ND  +  SK
Sbjct: 4830 AKATD---SGTYICQLSNDVGTATSK 4852



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 60/250 (24%), Positives = 93/250 (37%), Gaps = 55/250 (22%)

Query: 67   LRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPG 126
            L++ C ++    L   E + S        +G+  CTV+             V   + PP 
Sbjct: 6702 LKIPCAEMSDKGLYSFEVKNS--------VGKSNCTVS-----------VHVSDRIVPPS 6742

Query: 127  IKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG---------NTSELIF 177
              I    +  A+L G  V L CR +G   +   WF+   EI +G         N   L  
Sbjct: 6743 F-IRKLKDVNAIL-GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNL 6800

Query: 178  NAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQK 237
            + +   D G Y C   N       + S +     P SF+++ D V              +
Sbjct: 6801 SLLEPSDTGIYTCVAAN--VAGSDECSAVLTVQEPPSFEQTPDSV--------------E 6844

Query: 238  LMPGSTLVLQCVAVGSPIPHYQWFKNELPLT-HETKKLYMVPYV-DLE-------HQGTY 288
            ++PG +L    V  G+P    +WFK    L   E+  + +  +V +LE         G Y
Sbjct: 6845 VLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDY 6904

Query: 289  WCHVYNDRDS 298
             C V ND  S
Sbjct: 6905 SCLVTNDAGS 6914



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 60/148 (40%), Gaps = 30/148 (20%)

Query: 137  AVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP----------NGNTSELIFNAVHVKDAG 186
            + + G+ V+L     G   +   WFK   EI           + N + L F+ V   +AG
Sbjct: 7502 STVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAG 7561

Query: 187  FYVCRVNNNFTFE--FSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
             Y C++ N+   +  F+  S L+   I E                  +P S K+  G T 
Sbjct: 7562 KYTCQIKNDAGMQECFATLSVLEPATIVE------------------KPESIKVTTGDTC 7603

Query: 245  VLQCVAVGSPIPHYQWFKNELPLTHETK 272
             L+C   G+P    +WFK+   LT + K
Sbjct: 7604 TLECTVAGTPELSTKWFKDGKELTSDNK 7631



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 54/224 (24%), Positives = 88/224 (39%), Gaps = 36/224 (16%)

Query: 95   LMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHP 154
            L G+  CT T       +     + +  +PP   I + P    V  G+     C  TG  
Sbjct: 8123 LAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV--GESADFECHVTGTQ 8180

Query: 155  FVQYQWFKMNKEIPNGNTSELIF--NAVHVK-------DAGFYVCRVNNNFTFEFSQWSQ 205
             ++  W K ++EI +G   ++ +  N+ H+        D+G Y C   N    + S  +Q
Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKD-SCTAQ 8239

Query: 206  LDVCD--IPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
            L++ +  IP SF +        +L   VE T      G++  L+    GS      W+KN
Sbjct: 8240 LNIKERLIPPSFTK--------RLSETVEETE-----GNSFKLEGRVAGSQPITVAWYKN 8286

Query: 264  EL--------PLTHETKKLYM-VPYVDLEHQGTYWCHVYNDRDS 298
             +         +T +   L + V    +   G Y C V ND  S
Sbjct: 8287 NIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGS 8330



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 60/296 (20%), Positives = 107/296 (36%), Gaps = 54/296 (18%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN----TSE 174
            L + +PP    T  P     L G  V L C  +G P  +  W K  K++ N      TS+
Sbjct: 6452 LTVKAPP--VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSK 6509

Query: 175  LIFNAVHV-----KDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
                ++H+      D G Y C+  N            D C     F+     V       
Sbjct: 6510 HFDTSLHILNLEASDVGEYHCKATNEVGS--------DTCSCSVKFKEPPRFV------- 6554

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQ-----WFKNELPLTHETKKLYMVPYVD--- 281
                  +KL   STL+   V + + +  +Q     W K+   +  E++    + ++D   
Sbjct: 6555 ------KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENT-RISFIDNIA 6607

Query: 282  --------LEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKV 333
                      + G Y C + ND   ++   V  +++    +  P+    TT  P A + V
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECV 6667

Query: 334  ALLIGNMN---YREHPKLKAPLVDVYELTNLLRQLDFKVVSLLD--LTEYEMRNAV 384
                  ++   +++  +L A         N +  L      + D  L  +E++N+V
Sbjct: 6668 VTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSV 6723



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 64/266 (24%), Positives = 98/266 (36%), Gaps = 47/266 (17%)

Query: 63   SRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLL 122
            S GR   + L    C+L V   E S S       G+  C  T ++    + E +  L + 
Sbjct: 7723 SSGRKYQTTLTDNTCALTVNMLEESDS-------GDYTCIATNMAG---SDECSAPLTVR 7772

Query: 123  SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG---------NTS 173
             PP       P+   VL G  V       G P     WFK + E+  G         + +
Sbjct: 7773 EPPSF--VQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVA 7830

Query: 174  ELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
            EL    V    +G Y C V+N    + S  + L +   P  F + ++  S  K       
Sbjct: 7831 ELELFDVDTSQSGEYTCIVSNE-AGKASCTTHLYI-KAPAKFVKRLNDYSIEK------- 7881

Query: 234  TSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL---------THETKKLYMVPYVDLEH 284
                   G  L+L+    G+P     W KN + +         T E   +  +P   +E 
Sbjct: 7882 -------GKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVED 7934

Query: 285  QGTYWCHVYNDRDSQDSKKVEIIIDE 310
             G Y C++ N    +DS   +I+I E
Sbjct: 7935 AGQYNCYIEN-ASGKDSCSAQILILE 7959



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 50/230 (21%), Positives = 85/230 (36%), Gaps = 41/230 (17%)

Query: 114  EHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTS 173
            E+   L +L P  I     P +  V  G+   L C+  G P +  +W+K  K + +    
Sbjct: 5693 ENMATLMVLEPAVIVEKAGPMT--VTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKH 5750

Query: 174  ELIFN---------AVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCD--IPESFQRSVDGV 222
            +  F          +V  +DAG Y  +V NN   + S  + +DV D  +P SF R +   
Sbjct: 5751 KFSFYNKISSLRILSVERQDAGTYTFQVQNNVG-KSSCTAVVDVSDRAVPPSFTRRLKNT 5809

Query: 223  SESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPY--- 279
                            + G++ +L+C   GS      WF  +  +    K  Y   +   
Sbjct: 5810 GG--------------VLGASCILECKVAGSSPISVAWFHEKTKIVSGAK--YQTTFSDN 5853

Query: 280  --------VDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKE 321
                    +D    G Y C   N   S + + V  + +  + +  P+  E
Sbjct: 5854 VCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLE 5903



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 67/320 (20%), Positives = 122/320 (38%), Gaps = 43/320 (13%)

Query: 87   SPSLCLLKLM----GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQ 142
            S ++C L L      + G      ++   + E + VL +  PP  + T  P+S  VL G 
Sbjct: 6792 SENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQT--PDSVEVLPGM 6849

Query: 143  FVKLCCRATGHPFVQYQWFKMNKEIPNGNT---------SELIFNAVHVKDAGFYVCRVN 193
             +       G P  + +WFK ++E+  G +         +EL    V   ++G Y C V 
Sbjct: 6850 SLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVT 6909

Query: 194  NNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGS 253
            N+     S  + L V +     +R  D   E+               GS +VL+    G+
Sbjct: 6910 ND-AGSASCTTHLFVKEPATFVKRLADFSVET---------------GSPIVLEATYTGT 6953

Query: 254  PIPHYQWFKNELPLTHE-------TKKLYMVPYVD--LEHQGTYWCHVYNDRDSQDSKKV 304
            P     W K+E  ++         T+K  ++  ++  +E    Y C + N+      + +
Sbjct: 6954 PPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEAL 7013

Query: 305  EIIIDELNNLGHPDNKEQTTDQPL---AKDKVALLIGNMNYREHPKLKAPLVDVYELTNL 361
              +++    +   ++ E    +P     K      I    Y+EH KL++      +  N 
Sbjct: 7014 VSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNN 7073

Query: 362  LRQLDFKVVSLLDLTEYEMR 381
            +  L    V   D+ EY  +
Sbjct: 7074 VASLVINKVDHSDVGEYSCK 7093



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 50/213 (23%), Positives = 81/213 (38%), Gaps = 40/213 (18%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG------- 170
            +L +  PP     V P  +  +    V+      G P  + +WFK + E+ +G       
Sbjct: 5323 ILTVKEPPSF--LVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGL 5380

Query: 171  --NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
              +TS L   +V     G Y C V N+   + S  + L V + P  F + ++        
Sbjct: 5381 EGSTSFLNLYSVDASKTGQYTCHVTNDVGSD-SCTTMLLVTE-PPKFVKKLEA------- 5431

Query: 229  ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVD------- 281
                  S+ +  G +  L+C   GSP     WF+NE  L    K  Y + ++D       
Sbjct: 5432 ------SKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDK--YRMTFIDSVAVIQM 5483

Query: 282  ----LEHQGTYWCHVYNDRDSQDSKKVEIIIDE 310
                 E  G + C   N   S  S   ++I+ E
Sbjct: 5484 NNLSTEDSGDFICEAQNPAGS-TSCSTKVIVKE 5515



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/191 (24%), Positives = 73/191 (38%), Gaps = 37/191 (19%)

Query: 131  VNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG---------NTSELIFNAVH 181
            + P S  +  G+     C  TG   ++  W K N+EI  G         NT+ L    V 
Sbjct: 7216 LKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVG 7275

Query: 182  VKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 241
              DAG Y C   +N   + S  +QL V + P   ++             +EP S+ +   
Sbjct: 7276 KGDAGQYTCYA-SNIAGKDSCSAQLGVQEPPRFIKK-------------LEP-SRIVKQD 7320

Query: 242  STLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVD-----------LEHQGTYWC 290
                 +C   GSP     W+K+E  +   +K  + + +VD           +E  G Y C
Sbjct: 7321 EFTRYECKIGGSPEIKVLWYKDETEIQESSK--FRMSFVDSVAVLEMHNLSVEDSGDYTC 7378

Query: 291  HVYNDRDSQDS 301
              +N   S  S
Sbjct: 7379 EAHNAAGSASS 7389



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 45/225 (20%), Positives = 82/225 (36%), Gaps = 37/225 (16%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT----SE 174
            L++  PP  +    P     L G  V L C   G P     W+K  +E+ +G      SE
Sbjct: 7393 LKVKEPPIFR--KKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSE 7450

Query: 175  LIFNAVHV-----KDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
                ++H+      D G Y C+  N+   +    S       P  F + +  +S      
Sbjct: 7451 NFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSI--ALKAPPRFVKKLSDIST----- 7503

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM----------VPY 279
                     + G  + LQ    G+      WFK++  +  E+  +++             
Sbjct: 7504 ---------VVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSR 7554

Query: 280  VDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTT 324
            V+  + G Y C + ND   Q+      +++    +  P++ + TT
Sbjct: 7555 VEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTT 7599



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 49/207 (23%), Positives = 82/207 (39%), Gaps = 39/207 (18%)

Query: 68   RLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGI 127
            R+S +D    +L++  PE S S          G  + ++ +     E + VL +L P   
Sbjct: 6599 RISFID-NIATLQLGSPEASNS----------GKYICQIKNDAGMRECSAVLTVLEPA-- 6645

Query: 128  KITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF---------N 178
            +I   PE   V  G    L C  TG P +  +WFK  +E+   +   + F          
Sbjct: 6646 RIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIP 6705

Query: 179  AVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCD--IPESFQRSVDGVSESKLQICVEPTSQ 236
               + D G Y   V N+   + +    + V D  +P SF R +  V+             
Sbjct: 6706 CAEMSDKGLYSFEVKNS-VGKSNCTVSVHVSDRIVPPSFIRKLKDVN------------- 6751

Query: 237  KLMPGSTLVLQCVAVGSPIPHYQWFKN 263
              + G+++VL+C   GS      WF++
Sbjct: 6752 -AILGASVVLECRVSGSAPISVGWFQD 6777



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 44/214 (20%), Positives = 78/214 (36%), Gaps = 40/214 (18%)

Query: 118  VLQLLSPPGIKITVNP-ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG------ 170
            ++ +L PP     + P E    + G+   L C+  G P ++  W+K + ++ +       
Sbjct: 7013 LVSVLEPPYF---IEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQ 7069

Query: 171  ---NTSELIFNAVHVKDAGFYVCRVNNNF-TFEFSQWSQLDVCDIPESFQRSVDGVSESK 226
               N + L+ N V   D G Y C+ +N+      S    +    +P  F R +  V E+ 
Sbjct: 7070 FKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETL 7129

Query: 227  LQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN----------ELPLTHETKKLYM 276
                          G  +  +C   GS      W+K+          +    H    L +
Sbjct: 7130 --------------GFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQI 7175

Query: 277  VPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDE 310
            +   D  H G Y C   N   +  S   ++I+ E
Sbjct: 7176 L-QTDQSHIGQYNCSASNPLGTA-SSSAKLILSE 7207



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 33/142 (23%), Positives = 50/142 (35%), Gaps = 40/142 (28%)

Query: 141   GQFVKLCCRATGHPFVQYQWFKMNKEI---------PNGNTSELIFNAVHVKDAGFYVCR 191
             G+  +L C+  G P    +W++  KE+          +G T  L       +D G Y C 
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCI 30606

Query: 192   VNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP---------GS 242
               N            +V ++  S          SKL +   P      P         GS
Sbjct: 30607 ATN------------EVGEVETS----------SKLLLQATPQFHPGYPLKEKYYGAVGS 30644

Query: 243   TLVLQCVAVGSPIPHYQWFKNE 264
             TL L  + +G P+P   WF  +
Sbjct: 30645 TLRLHVMYIGRPVPAMTWFHGQ 30666



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 41/184 (22%), Positives = 69/184 (37%), Gaps = 34/184 (18%)

Query: 133  PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI---PNGNTSE------LIFNAVHVK 183
            P+S     G+  K  C  TG P ++  W K    +   PN   S+      L  + + ++
Sbjct: 3557 PKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQ 3616

Query: 184  DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGST 243
            D G Y C+ +N F  +  Q ++L + D P   +              +EP    +     
Sbjct: 3617 DRGVYSCKASNKFGADICQ-AELIIIDKPHFIKE-------------LEPVQSAI--NKK 3660

Query: 244  LVLQCVAVGSPIPHYQWFKN--ELPLTHETKKLYM-------VPYVDLEHQGTYWCHVYN 294
            + L+C           W K+  +LP   + K  +        +P   L+  GTY C   N
Sbjct: 3661 VHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720

Query: 295  DRDS 298
            +  S
Sbjct: 3721 EAGS 3724



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 10/88 (11%)

Query: 116  TEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL 175
            T +L +  PP   +     SK V AG   +L C+  G P ++  WF+   E+P  +   +
Sbjct: 5414 TTMLLVTEPPKF-VKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRM 5472

Query: 176  IF---------NAVHVKDAGFYVCRVNN 194
             F         N +  +D+G ++C   N
Sbjct: 5473 TFIDSVAVIQMNNLSTEDSGDFICEAQN 5500



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 14/37 (37%), Positives = 21/37 (56%)

Query: 232   EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLT 268
             +P SQ +  G  ++  C   G P P  +WFKN LP++
Sbjct: 33139 QPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPIS 33175



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 41/189 (21%), Positives = 76/189 (40%), Gaps = 39/189 (20%)

Query: 116   TEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTSE 174
             T+ ++LL  P  + T+   +K    G+ V+     T HP     W+K  ++I P  N  +
Sbjct: 31680 TDTMRLLERPP-EFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKK 31738

Query: 175   LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV--- 231
               F +    D G Y   +N+  T + ++++ +          R+  G    K ++ V   
Sbjct: 31739 YTFES----DKGLYQLTINSVTTDDDAEYTVV---------ARNKYGEDSCKAKLTVTLH 31785

Query: 232   -EPTSQKLMP-------------GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMV 277
               PT   L P             G ++  +    G P P  +W K+  PL+       + 
Sbjct: 31786 PPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS-------LG 31838

Query: 278   PYVDLEHQG 286
             P +++ H+G
Sbjct: 31839 PNIEIIHEG 31847



 Score = 37.4 bits (85), Expect = 0.056
 Identities = 49/232 (21%), Positives = 84/232 (36%), Gaps = 37/232 (15%)

Query: 111  QAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP-- 168
            +A   T V +L+     KI    E   V AG    L     G P ++ +W+K  + +   
Sbjct: 4001 EAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVAS 4060

Query: 169  -------NGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQ--WSQLDVCDIPESFQRSV 219
                     N ++L F +  + D+G Y   ++N       +  ++ LD  DI   F + +
Sbjct: 4061 KKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDR-DIAPFFTKPL 4119

Query: 220  DGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN----------ELPLTH 269
              V                +   T  L C   GS      WFK+           +    
Sbjct: 4120 RNVDS--------------VVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE 4165

Query: 270  ETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKE 321
             T  L ++  VD+   G + C   N   S+DS    I+ +  + +  P +K+
Sbjct: 4166 GTASLEIIR-VDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKD 4216



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 48/204 (23%), Positives = 77/204 (37%), Gaps = 53/204 (25%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG-------- 170
            ++L  PP     +N  S  V+AG+  +L     G   +  QW K  +E+           
Sbjct: 5604 VKLKEPPRFVSKLN--SLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661

Query: 171  --NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
              N + L F      +AG Y+C++ N+                         G+ E+   
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKND------------------------GGMRENMAT 5697

Query: 229  ICV-EPTS--QKLMP-----GSTLVLQCVAVGSPIPHYQWFKNELPLTHETK-------K 273
            + V EP    +K  P     G T  L+C   G+P    +W+K+   LT   K       K
Sbjct: 5698 LMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNK 5757

Query: 274  LYMVPYVDLEHQ--GTYWCHVYND 295
            +  +  + +E Q  GTY   V N+
Sbjct: 5758 ISSLRILSVERQDAGTYTFQVQNN 5781



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 44/202 (21%), Positives = 78/202 (38%), Gaps = 37/202 (18%)

Query: 87   SPSLCLLKL-------MGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVL 139
            S ++C L+L       MG   C    ++    + E   VL +  PP       PE   VL
Sbjct: 5851 SDNVCTLQLNSLDSSDMGNYTCVAANVAG---SDECRAVLTVQEPPSF--VKEPEPLEVL 5905

Query: 140  AGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN---------AVHVKDAGFYVC 190
             G+ V       G P  +  WF+  +E+  G+   + F           + +  +G Y C
Sbjct: 5906 PGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTC 5965

Query: 191  RVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVA 250
             V+NN   + S  ++L V + P +F + +              +   + PG +++L+   
Sbjct: 5966 VVSNN-AGQASCTTRLFVKE-PAAFLKRL--------------SDHSVEPGKSIILESTY 6009

Query: 251  VGSPIPHYQWFKNELPLTHETK 272
             G+      W K+   +T   K
Sbjct: 6010 TGTLPISVTWKKDGFNITTSEK 6031



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 48/213 (22%), Positives = 76/213 (35%), Gaps = 38/213 (17%)

Query: 116  TEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL 175
            TE++ +  PP    T+ P    ++ G    L C  +G    +  WFK  K+I +     L
Sbjct: 3823 TEIV-IKEPPSFIKTLEPAD--IVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRL 3879

Query: 176  IFN---------AVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESK 226
                        + +  D G Y C V N         + L     P +F + VD +    
Sbjct: 3880 FSQKSLVCLEIFSFNSADVGEYECVVANEVGKCGCMATHL--LKEPPTFVKKVDDLIA-- 3935

Query: 227  LQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK---------KLYMV 277
                        + G T+ LQ    GS      W K +  +  + K          + ++
Sbjct: 3936 ------------LGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLII 3983

Query: 278  PYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDE 310
            P V +   G Y C   N+  SQ S   E+I+ E
Sbjct: 3984 PDVQISFGGKYTCLAENEAGSQTSVG-ELIVKE 4015



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 44/172 (25%), Positives = 63/172 (36%), Gaps = 38/172 (22%)

Query: 144  VKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL-----IFNAVHV-----KDAGFYVCRVN 193
            V+L C  TG P  +  W K N+EI +     L     +FN +H+      D G Y C V+
Sbjct: 4972 VELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFN-LHITKCDPSDTGEYQCIVS 5030

Query: 194  NNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGS 253
            N         S       P SF +             +E T+  L   +T   Q    GS
Sbjct: 5031 NE--GGSCSCSTRVALKEPPSFIKK------------IENTTTVLKSSAT--FQSTVAGS 5074

Query: 254  PIPHYQWFKNELPLTHETKKLYM----------VPYVDLEHQGTYWCHVYND 295
            P     W K++  +  E   +Y+          +  VD  H G Y C   N+
Sbjct: 5075 PPISITWLKDD-QILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNE 5125



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 27/85 (31%), Positives = 36/85 (42%), Gaps = 11/85 (12%)

Query: 139   LAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN----------TSELIFNAVHVKDAGFY 188
             L G+ V +    +G P     W K    I N            TS +  N V  KDAGFY
Sbjct: 31040 LRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFY 31099

Query: 189   VCRVNNNFTFEFSQWSQLDVCDIPE 213
             V    N F  +  +  +LDV D+P+
Sbjct: 31100 VVCAKNRFGID-QKTVELDVADVPD 31123



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 37/173 (21%), Positives = 68/173 (39%), Gaps = 22/173 (12%)

Query: 113  MEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT 172
            +E T+  QL         + P S   L GQ  +   +  G P  +  WF   ++I N  T
Sbjct: 1443 LEETDESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYT 1502

Query: 173  SELIFNAVHVKDAGFYVCRVNNNFTFEFSQW----------SQLDVCDIPESFQRSVDGV 222
             +++     +K+ G     +      +  +W          S + V    E+ +  V  +
Sbjct: 1503 HKVV-----IKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPM 1557

Query: 223  SESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN-ELPLTHETKKL 274
               KL+      +  +  GS L ++  A G+P P   W KN ++ + H+  K+
Sbjct: 1558 FVEKLK------NVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKI 1604



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 51/221 (23%), Positives = 79/221 (35%), Gaps = 39/221 (17%)

Query: 98   EKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLA-GQFVKLCCRATGHPFV 156
            + G  + +LS+ +        L +  PP  +    P    VL  GQ     C+ TG P +
Sbjct: 4834 DSGTYICQLSNDVGTATSKATLFVKEPP--QFIKKPSPVLVLRNGQSTTFECQITGTPKI 4891

Query: 157  QYQWFKMNKEIPNGNTSELIF---------NAVHVKDAGFYVCRVNNNFTFEFSQWSQLD 207
            +  W+    EI       + F         +   V+++G YVC   N+     S   +L 
Sbjct: 4892 RVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARND-AGTASCSIELK 4950

Query: 208  VCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
            V + P +F R +  V   K               S + L+C   G+P     W KN   +
Sbjct: 4951 VKE-PPTFIRELKPVEVVKY--------------SDVELECEVTGTPPFEVTWLKNNREI 4995

Query: 268  THETKKLYMVPYV----------DLEHQGTYWCHVYNDRDS 298
               +KK  +   V          D    G Y C V N+  S
Sbjct: 4996 -RSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGS 5035



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 10/96 (10%)

Query: 133   PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP---------NGNTSELIFNAVHVK 183
             P S+ +  GQ V   C  +G P  + +WFK N  I          + N   L      V 
Sbjct: 33140 PRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVS 33199

Query: 184   DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSV 219
             D+G Y  +   NF  + S  + L V  + E   R V
Sbjct: 33200 DSGKYTIKA-KNFRGQCSATASLMVLPLVEEPSREV 33234



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 37/185 (20%), Positives = 67/185 (36%), Gaps = 40/185 (21%)

Query: 148  CRAT--GHPFVQYQWFKMNKEIPNGNTSELI---------FNAVHVKDAGFYVCRVNNNF 196
            CR T  G P +  +W    K +   N   +I         +   + +D+G   CR  N +
Sbjct: 1724 CRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKY 1783

Query: 197  TFEFS--------QWSQLDVCDIPES---FQR----------------SVDGVSESKLQI 229
              + +        + S ++   +PE     QR                + D   + K  I
Sbjct: 1784 GTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDI 1843

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYW 289
             + P   +++ G T   +C   G P P   W+ N   L  ++K+ + V Y  + +     
Sbjct: 1844 VLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNG-QLIRKSKR-FRVRYDGIHYLDIVD 1901

Query: 290  CHVYN 294
            C  Y+
Sbjct: 1902 CKSYD 1906



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 42/181 (23%), Positives = 58/181 (32%), Gaps = 36/181 (19%)

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVK---------DAGFY 188
            VL    V L     G P  +  WFK N  + +G   +       V          DAG Y
Sbjct: 4404 VLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEY 4463

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
             CRV N         S       P SF + ++  S  +              G T   Q 
Sbjct: 4464 QCRVTNEVGSSIC--SARVTLREPPSFIKKIESTSSLR--------------GGTAAFQA 4507

Query: 249  VAVGSPIPHYQWFKNELPLTHETK----------KLYMVPYVDLEHQGTYWCHVYNDRDS 298
               GS      W K+   +T +             LY+   ++++H G Y C   ND   
Sbjct: 4508 TLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSG-IEVKHDGKYVCQAKNDAGI 4566

Query: 299  Q 299
            Q
Sbjct: 4567 Q 4567



 Score = 33.5 bits (75), Expect = 0.81
 Identities = 15/56 (26%), Positives = 26/56 (46%)

Query: 129  ITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKD 184
            I + PE   VL G+  +  CR TG+P  +  W+   + I       + ++ +H  D
Sbjct: 1843 IVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLD 1898



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 35/155 (22%), Positives = 60/155 (38%), Gaps = 26/155 (16%)

Query: 54   WRRLAELAGSRGRLRLSCLDLEQCSLKVLEPE----GSPSLCLLKLMGEKGCTVTELSDF 109
            W + +    S G+ ++S L+     L VL+ +    G  +   +  +G+  CT       
Sbjct: 8186 WAKDSREIRSGGKYQISYLE-NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTA------ 8238

Query: 110  LQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN 169
                    + + L PP     ++ E+     G   KL  R  G   +   W+K N EI  
Sbjct: 8239 -----QLNIKERLIPPSFTKRLS-ETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQP 8292

Query: 170  GNTSELIFN---------AVHVKDAGFYVCRVNNN 195
             +  E+ F             + DAG Y C+V+N+
Sbjct: 8293 TSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSND 8327



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 31/118 (26%), Positives = 45/118 (38%), Gaps = 22/118 (18%)

Query: 91    CLLKLMGEKGCTV--TELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCC 148
             CLL    E  C V     S  L  +E   V           T N  +  V     +KL C
Sbjct: 12435 CLLDDEAEYSCEVRTARTSGMLTVLEEEAVF----------TKNLANIEVSETDTIKLVC 12484

Query: 149   RATGHPFVQYQWFKMNKEI---------PNGNTSELIFNAVHVKDAGFYVCRVNNNFT 197
               +  P  +  W+K ++EI           G    L+    H++DAG Y CR+ ++ T
Sbjct: 12485 EVS-KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRT 12541



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 19/60 (31%), Positives = 25/60 (41%), Gaps = 11/60 (18%)

Query: 146   LCCRATGHPFVQYQWFKMNKEIP-----------NGNTSELIFNAVHVKDAGFYVCRVNN 194
             L C+ TGHP    +W++  KEI             G   +LI  +V   DA  Y  R  N
Sbjct: 30947 LVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATN 31006



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 33/134 (24%), Positives = 46/134 (34%), Gaps = 23/134 (17%)

Query: 85    EGSPSLCLLKLMG-------EKGCTVTELSDFLQAMEHTEVLQLLSPPGIK-------IT 130
             EG  S   L+ MG       EK   ++E     Q    + V +   P   +       I 
Sbjct: 32796 EGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIV 32855

Query: 131   VNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSEL------IFNAVH--- 181
                +   V +    K   +ATG P     W K  K I  G   +L       F  +H   
Sbjct: 32856 TGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTD 32915

Query: 182   VKDAGFYVCRVNNN 195
               D+G Y C V N+
Sbjct: 32916 TSDSGLYTCTVKNS 32929



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 12/40 (30%), Positives = 21/40 (52%)

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF 177
            +L G  V   C+ +G+P  +  W+K  K I +G   ++ F
Sbjct: 1302 ILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDF 1341



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 23/97 (23%), Positives = 39/97 (40%), Gaps = 20/97 (20%)

Query: 109  FLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN---- 164
            ++ A E  +VLQ L P    +TV        +G+  + C   +G P  +  W+K      
Sbjct: 3232 YVNAPEPPQVLQELQP----VTVQ-------SGKPARFCAVISGRPQPKISWYKEEQLLS 3280

Query: 165  -----KEIPNGNTSELIFNAVHVKDAGFYVCRVNNNF 196
                 K + +G    L+      +DA  Y C   N++
Sbjct: 3281 TGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDY 3317



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 45/177 (25%), Positives = 68/177 (38%), Gaps = 19/177 (10%)

Query: 107   SDFLQAMEHTEVLQLLSPPGIKITVN-PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNK 165
             SD     E   V   L PP + +  N    + +  G  ++L     G PF +  W K ++
Sbjct: 17198 SDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDR 17257

Query: 166   EIPN---------GNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQ 216
             + P          G+  E I NA H +D G Y   V N    +      L V D P    
Sbjct: 17258 DAPTKARIDVTPVGSKLE-IRNAAH-EDGGIYSLTVENPAGSKTVSVKVL-VLDKPGP-P 17313

Query: 217   RSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK 273
             R ++ VSE +   C     + L  G +++   V     +   QW     PL+  +KK
Sbjct: 17314 RDLE-VSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQW----SPLSATSKK 17365



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 33/166 (19%), Positives = 66/166 (39%), Gaps = 16/166 (9%)

Query: 165   KEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQ-----RSV 219
             +++P+G  ++  F   +V +  F +  +  N  +EF  +++  V  I    +       +
Sbjct: 26807 RDLPDGRWTKASFT--NVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCI 26864

Query: 220   DGVSESKLQICVEPTSQ-KLMPGSTLVLQCVAVGSPIPHYQWFK-------NELPLTHET 271
             D      + + +E T   K   G+++ L+    G P P  +W+K       N L     T
Sbjct: 26865 DSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENT 26924

Query: 272   KKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHP 317
               L  +   D +   +  C+    R++  S    I +  L+  G P
Sbjct: 26925 TDLASILIKDADRLNS-GCYELKLRNAMGSASATIRVQILDKPGPP 26969



 Score = 30.0 bits (66), Expect = 9.0
 Identities = 42/186 (22%), Positives = 74/186 (39%), Gaps = 28/186 (15%)

Query: 226   KLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM--------- 276
             KL++ V   + K+  G  + +     G P+P  +W KNE  +   T  L +         
Sbjct: 15398 KLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSE 15457

Query: 277   ------VPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDEL----NNLGHPDNKEQ---- 322
                   +P    E +GTY     N R     + V + + +      NL   D K +    
Sbjct: 15458 AKTELSIPKAVREDKGTYTVTASN-RLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYL 15516

Query: 323   TTDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMR- 381
             T D PL      +    ++ R+  + KA   +  E+TN   +  + +  L+   +YE R 
Sbjct: 15517 TWDAPLDNGGSEITHYVIDKRDASRKKA---EWEEVTNTAVEKRYGIWKLIPNGQYEFRV 15573

Query: 382   NAVDEF 387
              AV+++
Sbjct: 15574 RAVNKY 15579


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 49/182 (26%), Positives = 70/182 (38%), Gaps = 33/182 (18%)

Query: 130 TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN-KEIPNGNTSEL-------IFNAVH 181
           T  P    + AG   +L C A GHP  Q  W K    + P      +       +F  V 
Sbjct: 606 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 665

Query: 182 VK--DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
           VK  D G Y C   N+     S  + L V + P   +  +D               + + 
Sbjct: 666 VKIEDIGVYSCTAQNS-AGSISANATLTVLETPSFLRPLLD---------------RTVT 709

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGTYWCHV 292
            G T VLQC+A GSP P   W K++ PL    +       +L ++   D+   G Y C +
Sbjct: 710 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 769

Query: 293 YN 294
            N
Sbjct: 770 SN 771



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 51/241 (21%), Positives = 91/241 (37%), Gaps = 50/241 (20%)

Query: 125 PGIKITVNPESKAVLAGQFVKLCCRA--TGHPFVQYQWFKMNKEIPNGN----------- 171
           P  +ITV PE+++ + G  +   C A  +    + + W K N+ + +             
Sbjct: 497 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 556

Query: 172 ------TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSES 225
                 T+ L    V     G Y C ++N+F   +S  ++L V  +P SF ++       
Sbjct: 557 GEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLP-SFTKT------- 608

Query: 226 KLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN---ELPLTHETK-------KLY 275
                  P    +  G+   L+C AVG P P   W K+   + P   E +        ++
Sbjct: 609 -------PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVF 661

Query: 276 MVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVAL 335
            +  V +E  G Y C   N   S  +     +++       P       D+ + K + A+
Sbjct: 662 FIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAV 715

Query: 336 L 336
           L
Sbjct: 716 L 716


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 49/182 (26%), Positives = 70/182 (38%), Gaps = 33/182 (18%)

Query: 130 TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN-KEIPNGNTSEL-------IFNAVH 181
           T  P    + AG   +L C A GHP  Q  W K    + P      +       +F  V 
Sbjct: 546 TKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVD 605

Query: 182 VK--DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
           VK  D G Y C   N+     S  + L V + P   +  +D               + + 
Sbjct: 606 VKIEDIGVYSCTAQNS-AGSISANATLTVLETPSFLRPLLD---------------RTVT 649

Query: 240 PGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGTYWCHV 292
            G T VLQC+A GSP P   W K++ PL    +       +L ++   D+   G Y C +
Sbjct: 650 KGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEM 709

Query: 293 YN 294
            N
Sbjct: 710 SN 711



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 51/241 (21%), Positives = 91/241 (37%), Gaps = 50/241 (20%)

Query: 125 PGIKITVNPESKAVLAGQFVKLCCRA--TGHPFVQYQWFKMNKEIPNGN----------- 171
           P  +ITV PE+++ + G  +   C A  +    + + W K N+ + +             
Sbjct: 437 PKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQG 496

Query: 172 ------TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSES 225
                 T+ L    V     G Y C ++N+F   +S  ++L V  +P SF ++       
Sbjct: 497 GEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLP-SFTKT------- 548

Query: 226 KLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN---ELPLTHETK-------KLY 275
                  P    +  G+   L+C AVG P P   W K+   + P   E +        ++
Sbjct: 549 -------PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVF 601

Query: 276 MVPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQPLAKDKVAL 335
            +  V +E  G Y C   N   S  +     +++       P       D+ + K + A+
Sbjct: 602 FIVDVKIEDIGVYSCTAQNSAGSISANATLTVLET------PSFLRPLLDRTVTKGETAV 655

Query: 336 L 336
           L
Sbjct: 656 L 656


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 50/215 (23%), Positives = 80/215 (37%), Gaps = 33/215 (15%)

Query: 97  GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHP-- 154
           G+ G       + +   E +  L +  PP     V P  + V  G+ V   C ATG+P  
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQEPP--HFVVKPRDQVVALGRTVTFQCEATGNPQP 341

Query: 155 ------------FVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQ 202
                          YQ  + +       T +L    V   D G+Y+C+  N      ++
Sbjct: 342 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK 401

Query: 203 WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK 262
            + L+V D+       V         I   P +Q +    T VL CVA GSP+P   W K
Sbjct: 402 -AYLEVTDVIADRPPPV---------IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK 451

Query: 263 NELPLTHETKKL-------YMVPYVDLEHQGTYWC 290
           + + ++ +  ++         + Y  L   G Y C
Sbjct: 452 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 486



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 51/228 (22%), Positives = 87/228 (38%), Gaps = 44/228 (19%)

Query: 124 PPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI--------------PN 169
           PP  +I  +P    V  G+   L C+A G P    +W+K  + +              P+
Sbjct: 28  PP--RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85

Query: 170 GNTSELIFNAVHVK----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSES 225
           G  S      VH +    D G YVC   N      S  + L+V  + + F+++       
Sbjct: 86  G--SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------- 136

Query: 226 KLQICVEPTSQKLMPGSTLVLQCVAV-GSPIPHYQWFKNELPLTHETKKL------YMVP 278
                  P+   +  G   V++C    G P P   W K+  PL  + +++       M+ 
Sbjct: 137 -------PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMIT 189

Query: 279 YVDLEHQGTYWCHVYNDRDSQDSKKVEI-IIDELNNLGHPDNKEQTTD 325
           Y      G Y C   N    ++S+  E+ +++  + +  P N   T D
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD 237



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 39/152 (25%), Positives = 54/152 (35%), Gaps = 24/152 (15%)

Query: 114 EHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG--- 170
           E  E+  L  P  +K    P + AV      +  C A G P    +W K + E+P     
Sbjct: 213 EVAELTVLERPSFVK---RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE 269

Query: 171 --NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
             +   L    V   D G Y C V  N   +    + L V + P                
Sbjct: 270 IRDDHTLKIRKVTAGDMGSYTC-VAENMVGKAEASATLTVQEPP---------------H 313

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQW 260
             V+P  Q +  G T+  QC A G+P P   W
Sbjct: 314 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 345



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 33/178 (18%)

Query: 132 NPESKAVLAGQFVKLCCRAT-GHPFVQYQWFKMNKEIPNGNT------SELIFNAVHVKD 184
           NP    V  G+   + C+   GHP     W K    + + +        +L+       D
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSD 195

Query: 185 AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
           AG YVC   N      S+ ++L V + P   +R       S L + V+ +++        
Sbjct: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRP------SNLAVTVDDSAE-------- 241

Query: 245 VLQCVAVGSPIPHYQWFKN--ELPLTH------ETKKLYMVPYVDLEHQGTYWCHVYN 294
             +C A G P+P  +W K+  ELP +        T K+  V   D+   G+Y C   N
Sbjct: 242 -FKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDM---GSYTCVAEN 295


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 50/215 (23%), Positives = 80/215 (37%), Gaps = 33/215 (15%)

Query: 97  GEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHP-- 154
           G+ G       + +   E +  L +  PP     V P  + V  G+ V   C ATG+P  
Sbjct: 323 GDMGSYTCVAENMVGKAEASATLTVQEPP--HFVVKPRDQVVALGRTVTFQCEATGNPQP 380

Query: 155 ------------FVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQ 202
                          YQ  + +       T +L    V   D G+Y+C+  N      ++
Sbjct: 381 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK 440

Query: 203 WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFK 262
            + L+V D+       V         I   P +Q +    T VL CVA GSP+P   W K
Sbjct: 441 -AYLEVTDVIADRPPPV---------IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRK 490

Query: 263 NELPLTHETKKL-------YMVPYVDLEHQGTYWC 290
           + + ++ +  ++         + Y  L   G Y C
Sbjct: 491 DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 525



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 51/228 (22%), Positives = 87/228 (38%), Gaps = 44/228 (19%)

Query: 124 PPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI--------------PN 169
           PP  +I  +P    V  G+   L C+A G P    +W+K  + +              P+
Sbjct: 67  PP--RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124

Query: 170 GNTSELIFNAVHVK----DAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSES 225
           G  S      VH +    D G YVC   N      S  + L+V  + + F+++       
Sbjct: 125 G--SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN------- 175

Query: 226 KLQICVEPTSQKLMPGSTLVLQCVAV-GSPIPHYQWFKNELPLTHETKKL------YMVP 278
                  P+   +  G   V++C    G P P   W K+  PL  + +++       M+ 
Sbjct: 176 -------PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMIT 228

Query: 279 YVDLEHQGTYWCHVYNDRDSQDSKKVEI-IIDELNNLGHPDNKEQTTD 325
           Y      G Y C   N    ++S+  E+ +++  + +  P N   T D
Sbjct: 229 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVD 276



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 39/152 (25%), Positives = 54/152 (35%), Gaps = 24/152 (15%)

Query: 114 EHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG--- 170
           E  E+  L  P  +K    P + AV      +  C A G P    +W K + E+P     
Sbjct: 252 EVAELTVLERPSFVK---RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE 308

Query: 171 --NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQ 228
             +   L    V   D G Y C V  N   +    + L V + P                
Sbjct: 309 IRDDHTLKIRKVTAGDMGSYTC-VAENMVGKAEASATLTVQEPP---------------H 352

Query: 229 ICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQW 260
             V+P  Q +  G T+  QC A G+P P   W
Sbjct: 353 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 384



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 44/178 (24%), Positives = 70/178 (39%), Gaps = 33/178 (18%)

Query: 132 NPESKAVLAGQFVKLCCRAT-GHPFVQYQWFKMNKEIPNGNT------SELIFNAVHVKD 184
           NP    V  G+   + C+   GHP     W K    + + +        +L+       D
Sbjct: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSD 234

Query: 185 AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
           AG YVC   N      S+ ++L V + P   +R       S L + V+ +++        
Sbjct: 235 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRP------SNLAVTVDDSAE-------- 280

Query: 245 VLQCVAVGSPIPHYQWFKN--ELPLTH------ETKKLYMVPYVDLEHQGTYWCHVYN 294
             +C A G P+P  +W K+  ELP +        T K+  V   D+   G+Y C   N
Sbjct: 281 -FKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDM---GSYTCVAEN 334


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 52/206 (25%), Positives = 82/206 (39%), Gaps = 28/206 (13%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            +++L PP I+     E   VL GQ   L C  TGHP  +  WFK  + +  G+   +  +
Sbjct: 1247 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 1306

Query: 179  AV-------HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
             V       ++  AG Y C +  N   E ++  QL V   P     + D   E       
Sbjct: 1307 GVLLQVLQANLSSAGHYSC-IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 1365

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVP--------YVDLE 283
             P S          L C A+  P P+  W K+  P    ++ + ++P            E
Sbjct: 1366 NPIS----------LICEALAFPSPNITWMKDGAPF-EASRNIQLLPGTHGLQILNAQKE 1414

Query: 284  HQGTYWCHVYND-RDSQDSKKVEIII 308
              G Y C V N+  ++  +  VE++I
Sbjct: 1415 DAGQYTCVVTNELGEAVKNYHVEVLI 1440



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 46/177 (25%), Positives = 71/177 (40%), Gaps = 21/177 (11%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK-----MNKEIPNGNTS 173
            LQ+  PP ++         V+ G  V+L C A G P     W K     +++ +  G + 
Sbjct: 2208 LQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSL 2267

Query: 174  ELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
            +L   AV   D+G Y C V  +   E  +  QL V + P              ++   +P
Sbjct: 2268 QL--EAVGAGDSGTYSC-VAVSEAGEARRHFQLTVMEPPH-------------IEDSGQP 2311

Query: 234  TSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 290
            T   L PG+ + L C A G+P P+  W K+   LT           + +   G Y C
Sbjct: 2312 TELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTC 2368



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 53/218 (24%), Positives = 84/218 (38%), Gaps = 30/218 (13%)

Query: 90   LCLLKLMGEKGCTVTELSDFLQAMEHTE-VLQLLSPPGIKITVNPESKAVLAGQFVKLCC 148
            L L +L   +  T T +++  QA    + V+ +L  P I+ +       VL GQ V+L C
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 2048

Query: 149  RATGHPFVQYQWFKMNKEIPNG---------NTSELIFNAVHVKDAGFYVCRVNNNFTFE 199
             A G P     W K    +            +   L+   +   DAG Y C V +N   E
Sbjct: 2049 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC-VAHNPAGE 2107

Query: 200  FSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQ 259
             ++   ++V  +P + ++  DG      +           PG  + + C   GSP  H  
Sbjct: 2108 DARLHTVNVL-VPPTIKQGADGSGTLVSR-----------PGELVTMVCPVRGSPPIHVS 2155

Query: 260  WFKNELP-------LTHETKKLYMVPYVDLEHQGTYWC 290
            W K+ LP       L H +     +  V L   G + C
Sbjct: 2156 WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2193



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 20/161 (12%)

Query: 119 LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT------ 172
           L++ +PP I  +      AV+    V+L C A G P     WFK    +P          
Sbjct: 304 LRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRG 363

Query: 173 -SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
             +L        DAG Y C+  +N      + ++LDV   P     +++G          
Sbjct: 364 GRQLQLGRAQSSDAGVYTCKA-SNAVGAAEKATRLDVYVPP-----TIEGAGG------- 410

Query: 232 EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK 272
            P   K + G  + L+CVA G P P   W    LP+    +
Sbjct: 411 RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNE 451



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 58/235 (24%), Positives = 93/235 (39%), Gaps = 32/235 (13%)

Query: 78  SLKVLEPEGSPSLCLLKLMG-EKGCTVTELSDFLQAMEHTEVLQLLSPPGIK-ITVNPES 135
           S KV+   G   L L +    + G    + S+ + A E    L +  PP I+     P  
Sbjct: 355 STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV 414

Query: 136 KAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVK-------DAGFY 188
              +AG+ V L C A GHP     W      +   N S L  +   ++        +G Y
Sbjct: 415 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLY 474

Query: 189 VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
            C  ++       Q+S ++V   P+        V+E   Q+         + G  L L C
Sbjct: 475 SCVASSPAGEAVLQYS-VEVQVPPQLL------VAEGLGQVTT-------IVGQPLELPC 520

Query: 249 VAVGSPIPHYQWFKNELP--------LTHETKKLYMVPYVDLEHQGTYWCHVYND 295
            A GSP+P  QW +N  P        +  +   L+ + +V+L+H G + C   N+
Sbjct: 521 QASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLH-IDHVELDHSGLFACQATNE 574



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 51/190 (26%), Positives = 79/190 (41%), Gaps = 28/190 (14%)

Query: 130  TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT-----SELIFNAVHVKD 184
            T  P  +++  G  + L C A G P  +  W   ++ +  G +     S L   AV  +D
Sbjct: 2941 TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRED 3000

Query: 185  AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
            +G YVC   N         S + V + P      + G + S L   VEP       G ++
Sbjct: 3001 SGTYVCWAENRVG-RTQAVSFVHVKEAPV-----LQGEAFSYL---VEPV------GGSI 3045

Query: 245  VLQCVAVGSPIPHYQWFKNELPL--THETKKL----YMVPYVDLEHQGTYWCHVYNDRDS 298
             L CV  G P+P   W K+ LPL  +H   +L      +   + +  G Y C   N+   
Sbjct: 3046 QLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGV 3105

Query: 299  QDSKKVEIII 308
              +KKV I++
Sbjct: 3106 --AKKVVILV 3113



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 48/166 (28%), Positives = 68/166 (40%), Gaps = 42/166 (25%)

Query: 119 LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN--GNTSE-- 174
           L++L PP I+    P +KAVL    V L C A+G P     WFK ++ + +  G T    
Sbjct: 689 LKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 746

Query: 175 ---LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESK--LQI 229
              L      + DAG Y C  +N                        V G +E +  L++
Sbjct: 747 GRVLRIEQAQLSDAGSYRCVASN------------------------VAGSTELRYGLRV 782

Query: 230 CVEP--TSQKLMPGSTLV-----LQCVAVGSPIPHYQWFKNELPLT 268
            V P  T    +PG  LV     L C A G+P P   W K+  P++
Sbjct: 783 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVS 828



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 44/191 (23%), Positives = 75/191 (39%), Gaps = 23/191 (12%)

Query: 85   EGSPSLCLLKL-MGEKGC-TVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQ 142
            E  PSL L  +  G+ G  +   +S+  +A  H + L ++ PP I+ +  P   ++  G 
Sbjct: 2262 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ-LTVMEPPHIEDSGQPTELSLTPGA 2320

Query: 143  FVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQ 202
             ++L C A G P     W K  + +     +      + V+DAG Y C            
Sbjct: 2321 PMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTC------------ 2368

Query: 203  WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG---STLVLQCVAVGSPIPHYQ 259
             ++     I +SF+  V           V P   + + G     LVL+C     P P   
Sbjct: 2369 LAESPAGAIEKSFRVRVQAPPN-----IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 2423

Query: 260  WFKNELPLTHE 270
            W ++ + L  +
Sbjct: 2424 WHRDGIVLQED 2434



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 47/188 (25%), Positives = 68/188 (36%), Gaps = 35/188 (18%)

Query: 134  ESKAVLAGQFVKLCCRATGHPFVQYQWFK--------MNKEIPNGNTSELIFNAVHVKDA 185
            E   V     + L C A   P     W K         N ++  G     I NA   +DA
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNA-QKEDA 1416

Query: 186  GFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVD----GVSESKLQICVEPTSQKLMPG 241
            G Y C V N        +  ++V  IP S  +       GV E K ++            
Sbjct: 1417 GQYTCVVTNELGEAVKNY-HVEVL-IPPSISKDDPLGEVGVKEVKTKV-----------N 1463

Query: 242  STLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGTYWCHVYN 294
            STL L+C +   P P  +W+K+  P+T  ++       +L  +    +   G Y C   N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 295  --DRDSQD 300
                D QD
Sbjct: 1524 VAGEDDQD 1531



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 41/181 (22%)

Query: 133  PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI----FNAVHV--KDAG 186
            P     +A + V L C A+G P     W K    +  G +++++        H   +DAG
Sbjct: 2763 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAG 2822

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP------ 240
             Y+C   N+                      +   + +++L + V P  +  +P      
Sbjct: 2823 NYLCIAKNS----------------------AGSAMGKTRLVVQVPPVIENGLPDLSTTE 2860

Query: 241  GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDL-------EHQGTYWCHVY 293
            GS   L C A GSP P+  W K+  P++    K  + P  +L       +  GTY C   
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 2920

Query: 294  N 294
            N
Sbjct: 2921 N 2921



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/170 (23%), Positives = 61/170 (35%), Gaps = 36/170 (21%)

Query: 141  GQFVKLCCRATGHPFVQYQWFK---------MNKEIPNGNTSELIFNAVHVKDAGFYVCR 191
            G  ++L C   G P     W K         +  ++ NG+   L  +     DAG Y C 
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGS---LTIHRTERDDAGRYQCL 3098

Query: 192  VNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAV 251
              N                     ++ V  V +S     VEP    +  G  + L+C A 
Sbjct: 3099 AENEMGVA----------------KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3142

Query: 252  GSPIPHYQWFKNELPLTHETKKLYMVP-------YVDLEHQGTYWCHVYN 294
            G P P  +W +   PL   +++L  +P        V+    GTY C  +N
Sbjct: 3143 GEPTPTIEWLQAGQPL-RASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 3191



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/198 (23%), Positives = 69/198 (34%), Gaps = 43/198 (21%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQF-VKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF 177
            L +L PP +   ++P +    A    + L C A G P    +WF+  + +  G  + L+ 
Sbjct: 1153 LSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA 1212

Query: 178  NAVHVK-------DAGFYVCRVNN-------NFTFEFSQWSQLDVCDIPESFQRSVDGVS 223
                +K       D+G Y C  +N       NF+ E      ++  D+ E          
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVI-------- 1264

Query: 224  ESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK-------LYM 276
                         K++ G T  L C   G P P   WFK+  PL             L  
Sbjct: 1265 -------------KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQ 1311

Query: 277  VPYVDLEHQGTYWCHVYN 294
            V   +L   G Y C   N
Sbjct: 1312 VLQANLSSAGHYSCIAAN 1329



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 44/190 (23%), Positives = 72/190 (37%), Gaps = 27/190 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG-------N 171
            L++  PP I   ++ E    +    V L C    HP  +  W+K ++ +  G        
Sbjct: 1740 LRVQVPPRIA-GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG 1798

Query: 172  TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
            T  L      + D+G Y C   N    +  +  QL V  +P +F+++  G  ++ L    
Sbjct: 1799 THTLQLGRARLSDSGMYTCEALNAAGRD-QKLVQLSVL-VPPAFRQAPRGPQDAVL---- 1852

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELP--LTHETKKL-----YMVPYVDLEH 284
                  +  G   VL C     P P   W+K+  P  L   T+ L       +    +  
Sbjct: 1853 ------VRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 1906

Query: 285  QGTYWCHVYN 294
            +G Y C V N
Sbjct: 1907 KGLYSCKVSN 1916



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 40/158 (25%), Positives = 58/158 (36%), Gaps = 24/158 (15%)

Query: 119  LQLLSPPGIKITVNPESKAVLA--GQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI 176
            L +L PP  +        AVL   G    L C     P     W+K  + +     ++ +
Sbjct: 1832 LSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL 1891

Query: 177  -------FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
                        V D G Y C+V+N    E  +   L V  +P +F+             
Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTV-QVPPTFENPK---------- 1939

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
              E  SQ  + GS LVL C   G P P   W K+ +P+
Sbjct: 1940 -TETVSQ--VAGSPLVLTCDVSGVPAPTVTWLKDRMPV 1974



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 36/181 (19%), Positives = 69/181 (38%), Gaps = 26/181 (14%)

Query: 134  ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNA-------VHVKDAG 186
            E + ++      L C     P     W++ ++ +  G+   ++          V  ++AG
Sbjct: 1567 EYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 1626

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVL 246
             Y C+ +N    ++  +  L V   P     + + V E  +              ST+ L
Sbjct: 1627 RYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNA-----------SSTVSL 1674

Query: 247  QCVAVGSPIPHYQWFKNELPLTH-------ETKKLYMVPYVDLEHQGTYWCHVYNDRDSQ 299
            QC A+G+P+P   W +N LP +        E  ++  V   ++    +Y C   N   S 
Sbjct: 1675 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1734

Query: 300  D 300
            +
Sbjct: 1735 E 1735



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 46/185 (24%), Positives = 70/185 (37%), Gaps = 19/185 (10%)

Query: 119 LQLLSPPGIKITVNPESKA-VLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTSELI 176
           L++  PP  +IT+ P     VL    V+L C ATG P     W K    + P G     +
Sbjct: 780 LRVNVPP--RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 837

Query: 177 FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQ 236
           F        G  V  + +    +  ++S + V  + E  Q  V  V      I  E  + 
Sbjct: 838 F-------PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEELNV 889

Query: 237 KLMPGSTLVLQCVAVGSPIPHYQWFKNELPL-------THETKKLYMVPYVDLEHQGTYW 289
            ++   ++ L+C +   P P   W+K+  PL           K L  V   D+   G Y 
Sbjct: 890 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT 949

Query: 290 CHVYN 294
           C   N
Sbjct: 950 CEALN 954



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 40/169 (23%), Positives = 60/169 (35%), Gaps = 38/169 (22%)

Query: 123 SPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNG-------NTSE 174
           +PP +      +    LAG  V+L C  +G P  Q +W K  + + P G       +   
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV 273

Query: 175 LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPT 234
           L     HV D G Y C                       +F  +     + +L++   PT
Sbjct: 274 LRITGSHVGDEGRYQC----------------------VAFSPAGQQARDFQLRVHAPPT 311

Query: 235 --------SQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLY 275
                      +M    + L C A G P P+  WFK+   L   TK +Y
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 360



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 39/156 (25%), Positives = 58/156 (37%), Gaps = 32/156 (20%)

Query: 115  HTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTS 173
            HT       PP + ++VN         Q   L C+A G P     W K    + P     
Sbjct: 2479 HTVPTIRSGPPAVNVSVN---------QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF 2529

Query: 174  ELI------FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
            E++         V  +DAG Y+C  +N+   +  Q   L V + P               
Sbjct: 2530 EILPEGSLRIQPVLAQDAGHYLCLASNSAGSD-RQGRDLRVLEPPA-------------- 2574

Query: 228  QICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
             I   P++  L   +  +L C A GSP P   W+K+
Sbjct: 2575 -IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 2609



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 42/174 (24%), Positives = 60/174 (34%), Gaps = 31/174 (17%)

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV---------HVKDAGFY 188
            V  G    L C   G PF +  W K  + +P         +AV          +   G Y
Sbjct: 983  VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 1042

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
             C  +N      SQ  QL+V   P+     + G  E        PT   ++      L+C
Sbjct: 1043 TCECSN-VVGNSSQDLQLEVHVPPQ-----IAGPREP-------PTQVSVVQDGVATLEC 1089

Query: 249  VAVGSPIPHYQWFKNELP--------LTHETKKLYMVPYVDLEHQGTYWCHVYN 294
             A G P P   W ++  P        L ++ + L+ V      H G Y C   N
Sbjct: 1090 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLH-VERAQAAHTGRYSCVAEN 1142



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 14/86 (16%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN---------KEIP 168
            +L L S P  +  V P+   V +G  V L C+ATG P    +W +           + +P
Sbjct: 3111 ILVLQSAPVFQ--VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLP 3168

Query: 169  NGNTSELIFNAVHVKDAGFYVCRVNN 194
            +G+   L    V   DAG Y C  +N
Sbjct: 3169 DGS---LWLENVETGDAGTYDCVAHN 3191



 Score = 33.5 bits (75), Expect = 0.81
 Identities = 45/212 (21%), Positives = 76/212 (35%), Gaps = 34/212 (16%)

Query: 112  AMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN 171
            A+E +  +++ +PP I     P     LA   + L C     P  +  W +    +    
Sbjct: 2376 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDA 2435

Query: 172  TSE-------LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE 224
             ++       L   A+   D+G Y C   N      S   ++++  +P            
Sbjct: 2436 HTQFPERGRFLQLQALSTADSGDYSCTARNA-AGSTSVAFRVEIHTVPT----------- 2483

Query: 225  SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEH 284
                I   P +  +    T +L C A G P P   W K+ +PL   + +  ++P   L  
Sbjct: 2484 ----IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRI 2539

Query: 285  Q-------GTYWCHVYN----DRDSQDSKKVE 305
            Q       G Y C   N    DR  +D + +E
Sbjct: 2540 QPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE 2571



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 16/69 (23%), Positives = 31/69 (44%), Gaps = 7/69 (10%)

Query: 233 PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLT-------HETKKLYMVPYVDLEHQ 285
           P ++ ++  +++ L+C+A G P P   WFK   P++           ++  +    L   
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDA 760

Query: 286 GTYWCHVYN 294
           G+Y C   N
Sbjct: 761 GSYRCVASN 769



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 51/229 (22%), Positives = 93/229 (40%), Gaps = 29/229 (12%)

Query: 96   MGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESK-AVLAGQFVKLCCRATGHP 154
            + ++G    E S+ +        L++  PP I     P ++ +V+      L C ATG P
Sbjct: 1036 LAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1095

Query: 155  FVQYQWFKMNKEIPN--GNTSELIFNAVHVKDA-----GFYVCRVNNNFTFEFSQWSQLD 207
                 W +  + +    G   +    ++HV+ A     G Y C V  N      +  +L 
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC-VAENLAGRAERKFELS 1154

Query: 208  VCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
            V  +P      +D ++     +            S L L C A+G P P  +WF+ E P+
Sbjct: 1155 VL-VPPELIGDLDPLTNITAAL-----------HSPLTLLCEAMGIPPPAIRWFRGEEPV 1202

Query: 268  T--HETKKL---YMVPYVDLEHQ--GTYWCHVYNDR-DSQDSKKVEIII 308
            +   +T  L   +M+     + Q  G Y C   N+  +++ +  VE+++
Sbjct: 1203 SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV 1251


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 52/206 (25%), Positives = 82/206 (39%), Gaps = 28/206 (13%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFN 178
            +++L PP I+     E   VL GQ   L C  TGHP  +  WFK  + +  G+   +  +
Sbjct: 2438 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 2497

Query: 179  AV-------HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
             V       ++  AG Y C +  N   E ++  QL V   P     + D   E       
Sbjct: 2498 GVLLQVLQANLSSAGHYSC-IAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVN 2556

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVP--------YVDLE 283
             P S          L C A+  P P+  W K+  P    ++ + ++P            E
Sbjct: 2557 NPIS----------LICEALAFPSPNITWMKDGAPF-EASRNIQLLPGTHGLQILNAQKE 2605

Query: 284  HQGTYWCHVYND-RDSQDSKKVEIII 308
              G Y C V N+  ++  +  VE++I
Sbjct: 2606 DAGQYTCVVTNELGEAVKNYHVEVLI 2631



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 46/177 (25%), Positives = 71/177 (40%), Gaps = 21/177 (11%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFK-----MNKEIPNGNTS 173
            LQ+  PP ++         V+ G  V+L C A G P     W K     +++ +  G + 
Sbjct: 3399 LQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSL 3458

Query: 174  ELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEP 233
            +L   AV   D+G Y C V  +   E  +  QL V + P              ++   +P
Sbjct: 3459 QL--EAVGAGDSGTYSC-VAVSEAGEARRHFQLTVMEPPH-------------IEDSGQP 3502

Query: 234  TSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 290
            T   L PG+ + L C A G+P P+  W K+   LT           + +   G Y C
Sbjct: 3503 TELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTC 3559



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 63/244 (25%), Positives = 96/244 (39%), Gaps = 28/244 (11%)

Query: 59   ELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEV 118
            E+  S  RL LS    E+  L    P GS  L  +++ G+ G      S+   +  H  V
Sbjct: 1058 EMRLSVNRLALSKYVWEEYGLL---PSGSLRLAQVQV-GDSGHYECTASNPAGSASHRYV 1113

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP-NGNTSELIF 177
            L +  PP  ++   P    VL G+ + L C A G+P  Q  W K    +   G    + F
Sbjct: 1114 LGVQVPP--QVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHF 1171

Query: 178  NAVHVKDAGFYVCRVNNNFTFEFSQWS-QLDVCDIPESFQRSVDGVSESKLQICVEPTSQ 236
             A+   DAG Y C  +N+   +   W  +L V + P        G+ E            
Sbjct: 1172 AAIRTSDAGRYRCEASNSAGVD--AWEVELRVLEPPHWGADETSGLLER----------- 1218

Query: 237  KLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDR 296
              + G    L C A G+P P   W K        ++ L+  P V +  +G+ +    +  
Sbjct: 1219 --VAGENASLPCPARGTPKPQVTWRKGP-----SSEPLHGQPGVAVLEEGSLFLASVSPA 1271

Query: 297  DSQD 300
            DS D
Sbjct: 1272 DSGD 1275



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 53/218 (24%), Positives = 84/218 (38%), Gaps = 30/218 (13%)

Query: 90   LCLLKLMGEKGCTVTELSDFLQAMEHTE-VLQLLSPPGIKITVNPESKAVLAGQFVKLCC 148
            L L +L   +  T T +++  QA    + V+ +L  P I+ +       VL GQ V+L C
Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 3239

Query: 149  RATGHPFVQYQWFKMNKEIPNG---------NTSELIFNAVHVKDAGFYVCRVNNNFTFE 199
             A G P     W K    +            +   L+   +   DAG Y C V +N   E
Sbjct: 3240 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTC-VAHNPAGE 3298

Query: 200  FSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQ 259
             ++   ++V  +P + ++  DG      +           PG  + + C   GSP  H  
Sbjct: 3299 DARLHTVNVL-VPPTIKQGADGSGTLVSR-----------PGELVTMVCPVRGSPPIHVS 3346

Query: 260  WFKNELP-------LTHETKKLYMVPYVDLEHQGTYWC 290
            W K+ LP       L H +     +  V L   G + C
Sbjct: 3347 WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 3384



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 20/161 (12%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT------ 172
            L++ +PP I  +      AV+    V+L C A G P     WFK    +P          
Sbjct: 1495 LRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRG 1554

Query: 173  -SELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
              +L        DAG Y C+  +N      + ++LDV   P     +++G          
Sbjct: 1555 GRQLQLGRAQSSDAGVYTCKA-SNAVGAAEKATRLDVYVPP-----TIEGAGG------- 1601

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETK 272
             P   K + G  + L+CVA G P P   W    LP+    +
Sbjct: 1602 RPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNE 1642



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 58/235 (24%), Positives = 93/235 (39%), Gaps = 32/235 (13%)

Query: 78   SLKVLEPEGSPSLCLLKLMG-EKGCTVTELSDFLQAMEHTEVLQLLSPPGIK-ITVNPES 135
            S KV+   G   L L +    + G    + S+ + A E    L +  PP I+     P  
Sbjct: 1546 STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYV 1605

Query: 136  KAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVK-------DAGFY 188
               +AG+ V L C A GHP     W      +   N S L  +   ++        +G Y
Sbjct: 1606 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLY 1665

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
             C  ++       Q+S ++V   P+        V+E   Q+         + G  L L C
Sbjct: 1666 SCVASSPAGEAVLQYS-VEVQVPPQLL------VAEGLGQVTT-------IVGQPLELPC 1711

Query: 249  VAVGSPIPHYQWFKNELP--------LTHETKKLYMVPYVDLEHQGTYWCHVYND 295
             A GSP+P  QW +N  P        +  +   L+ + +V+L+H G + C   N+
Sbjct: 1712 QASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLH-IDHVELDHSGLFACQATNE 1765



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 70/289 (24%), Positives = 107/289 (37%), Gaps = 49/289 (16%)

Query: 20  PLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGW-RRLAELAGSRGRL-RLSCLDLEQC 77
           P L P    T++     +L     +L +AP    W R    L  S GR+ +L+ L LE  
Sbjct: 518 PQLVPAPNVTVSPGETAVLS--CRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEIS 575

Query: 78  SLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKA 137
              ++  +G    C+          VT  S +L   E  +V           +++  S+ 
Sbjct: 576 G--IIPTDGGRYQCV----ASNANGVTRASVWLLVREAPQV-----------SIHTSSQH 618

Query: 138 VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT------SELIFNAVHVKDAGFYVCR 191
              G  VK+ C A+G+P     W + ++ +   +         LI   V  +DAG Y C+
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 678

Query: 192 VNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAV 251
             N    +  +   L   D P     SV  V+   L          +  G   VL C A 
Sbjct: 679 ATNEVGTD-QETVTLYYTDPP-----SVSAVNAVVL----------VAVGEEAVLVCEAS 722

Query: 252 GSPIPHYQWFKNEL-----PLTHETKKLYMVPYVDLEHQGTYWCHVYND 295
           G P P   W++  L     P    + KL  +P       GTY C   N+
Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKL-RIPAAQERDAGTYTCRAVNE 770



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 66/274 (24%), Positives = 103/274 (37%), Gaps = 51/274 (18%)

Query: 81  VLEPEGSPSLCLL------KLMGEKGC-TVTELSDFLQAMEHTEVLQLLSPPGIKITVNP 133
           +L PEGS S  L       +  G   C  V EL D       +  +QL      ++T  P
Sbjct: 739 ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA------SAEIQLAVGHAPQLTELP 792

Query: 134 ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG--------------NTSELIFNA 179
               V  G+   L CRATG P     W + + + P G              ++  L F +
Sbjct: 793 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVLFFES 851

Query: 180 VHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLM 239
           V  +D   YVC   N F              +    +  V G   +  QI     + +++
Sbjct: 852 VAPEDQAPYVCEARNVFG------------KVQAEARLIVTG--HAPPQIASSAPTVRVL 897

Query: 240 PGSTLVLQCVAV-GSPIPHYQWFKNELPLTHETKKLYMVP---YVD---LEHQGTYWCHV 292
            G  + L C+ + G P+P   W K+  PL   ++         ++D    EH G Y C  
Sbjct: 898 EGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 957

Query: 293 YNDRDSQDSKKVEIIIDELNNLGHPDNKEQTTDQ 326
            N   SQ  + VE+++     + HP      T++
Sbjct: 958 TNTAGSQ-HRDVELVVQVPPRI-HPTATHHITNE 989



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 51/190 (26%), Positives = 79/190 (41%), Gaps = 28/190 (14%)

Query: 130  TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNT-----SELIFNAVHVKD 184
            T  P  +++  G  + L C A G P  +  W   ++ +  G +     S L   AV  +D
Sbjct: 4132 TTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRED 4191

Query: 185  AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 244
            +G YVC   N         S + V + P      + G + S L   VEP       G ++
Sbjct: 4192 SGTYVCWAENRVG-RTQAVSFVHVKEAPV-----LQGEAFSYL---VEPV------GGSI 4236

Query: 245  VLQCVAVGSPIPHYQWFKNELPL--THETKKL----YMVPYVDLEHQGTYWCHVYNDRDS 298
             L CV  G P+P   W K+ LPL  +H   +L      +   + +  G Y C   N+   
Sbjct: 4237 QLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGV 4296

Query: 299  QDSKKVEIII 308
              +KKV I++
Sbjct: 4297 --AKKVVILV 4304



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 48/166 (28%), Positives = 68/166 (40%), Gaps = 42/166 (25%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPN--GNTSE-- 174
            L++L PP I+    P +KAVL    V L C A+G P     WFK ++ + +  G T    
Sbjct: 1880 LKVLVPPNIE--PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVD 1937

Query: 175  ---LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESK--LQI 229
               L      + DAG Y C  +N                        V G +E +  L++
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVASN------------------------VAGSTELRYGLRV 1973

Query: 230  CVEP--TSQKLMPGSTLV-----LQCVAVGSPIPHYQWFKNELPLT 268
             V P  T    +PG  LV     L C A G+P P   W K+  P++
Sbjct: 1974 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVS 2019



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 44/191 (23%), Positives = 75/191 (39%), Gaps = 23/191 (12%)

Query: 85   EGSPSLCLLKL-MGEKGC-TVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQ 142
            E  PSL L  +  G+ G  +   +S+  +A  H + L ++ PP I+ +  P   ++  G 
Sbjct: 3453 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ-LTVMEPPHIEDSGQPTELSLTPGA 3511

Query: 143  FVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQ 202
             ++L C A G P     W K  + +     +      + V+DAG Y C            
Sbjct: 3512 PMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTC------------ 3559

Query: 203  WSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG---STLVLQCVAVGSPIPHYQ 259
             ++     I +SF+  V           V P   + + G     LVL+C     P P   
Sbjct: 3560 LAESPAGAIEKSFRVRVQAPPN-----IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT 3614

Query: 260  WFKNELPLTHE 270
            W ++ + L  +
Sbjct: 3615 WHRDGIVLQED 3625



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 47/188 (25%), Positives = 68/188 (36%), Gaps = 35/188 (18%)

Query: 134  ESKAVLAGQFVKLCCRATGHPFVQYQWFK--------MNKEIPNGNTSELIFNAVHVKDA 185
            E   V     + L C A   P     W K         N ++  G     I NA   +DA
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNA-QKEDA 2607

Query: 186  GFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVD----GVSESKLQICVEPTSQKLMPG 241
            G Y C V N        +  ++V  IP S  +       GV E K ++            
Sbjct: 2608 GQYTCVVTNELGEAVKNY-HVEVL-IPPSISKDDPLGEVGVKEVKTKV-----------N 2654

Query: 242  STLVLQCVAVGSPIPHYQWFKNELPLTHETK-------KLYMVPYVDLEHQGTYWCHVYN 294
            STL L+C +   P P  +W+K+  P+T  ++       +L  +    +   G Y C   N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 295  --DRDSQD 300
                D QD
Sbjct: 2715 VAGEDDQD 2722



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 41/181 (22%)

Query: 133  PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI----FNAVHV--KDAG 186
            P     +A + V L C A+G P     W K    +  G +++++        H   +DAG
Sbjct: 3954 PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAG 4013

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP------ 240
             Y+C   N+                      +   + +++L + V P  +  +P      
Sbjct: 4014 NYLCIAKNS----------------------AGSAMGKTRLVVQVPPVIENGLPDLSTTE 4051

Query: 241  GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDL-------EHQGTYWCHVY 293
            GS   L C A GSP P+  W K+  P++    K  + P  +L       +  GTY C   
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 4111

Query: 294  N 294
            N
Sbjct: 4112 N 4112



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/170 (23%), Positives = 61/170 (35%), Gaps = 36/170 (21%)

Query: 141  GQFVKLCCRATGHPFVQYQWFK---------MNKEIPNGNTSELIFNAVHVKDAGFYVCR 191
            G  ++L C   G P     W K         +  ++ NG+   L  +     DAG Y C 
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGS---LTIHRTERDDAGRYQCL 4289

Query: 192  VNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAV 251
              N                     ++ V  V +S     VEP    +  G  + L+C A 
Sbjct: 4290 AENEMGVA----------------KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 4333

Query: 252  GSPIPHYQWFKNELPLTHETKKLYMVP-------YVDLEHQGTYWCHVYN 294
            G P P  +W +   PL   +++L  +P        V+    GTY C  +N
Sbjct: 4334 GEPTPTIEWLQAGQPL-RASRRLRTLPDGSLWLENVETGDAGTYDCVAHN 4382



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 46/198 (23%), Positives = 69/198 (34%), Gaps = 43/198 (21%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQF-VKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIF 177
            L +L PP +   ++P +    A    + L C A G P    +WF+  + +  G  + L+ 
Sbjct: 2344 LSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA 2403

Query: 178  NAVHVK-------DAGFYVCRVNN-------NFTFEFSQWSQLDVCDIPESFQRSVDGVS 223
                +K       D+G Y C  +N       NF+ E      ++  D+ E          
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVI-------- 2455

Query: 224  ESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKK-------LYM 276
                         K++ G T  L C   G P P   WFK+  PL             L  
Sbjct: 2456 -------------KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQ 2502

Query: 277  VPYVDLEHQGTYWCHVYN 294
            V   +L   G Y C   N
Sbjct: 2503 VLQANLSSAGHYSCIAAN 2520



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 44/190 (23%), Positives = 72/190 (37%), Gaps = 27/190 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG-------N 171
            L++  PP I   ++ E    +    V L C    HP  +  W+K ++ +  G        
Sbjct: 2931 LRVQVPPRIA-GLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPG 2989

Query: 172  TSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICV 231
            T  L      + D+G Y C   N    +  +  QL V  +P +F+++  G  ++ L    
Sbjct: 2990 THTLQLGRARLSDSGMYTCEALNAAGRD-QKLVQLSVL-VPPAFRQAPRGPQDAVL---- 3043

Query: 232  EPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELP--LTHETKKL-----YMVPYVDLEH 284
                  +  G   VL C     P P   W+K+  P  L   T+ L       +    +  
Sbjct: 3044 ------VRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSD 3097

Query: 285  QGTYWCHVYN 294
            +G Y C V N
Sbjct: 3098 KGLYSCKVSN 3107



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 40/158 (25%), Positives = 58/158 (36%), Gaps = 24/158 (15%)

Query: 119  LQLLSPPGIKITVNPESKAVLA--GQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELI 176
            L +L PP  +        AVL   G    L C     P     W+K  + +     ++ +
Sbjct: 3023 LSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL 3082

Query: 177  -------FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQI 229
                        V D G Y C+V+N    E  +   L V  +P +F+             
Sbjct: 3083 RGGQRLEIQEAQVSDKGLYSCKVSN-VAGEAVRTFTLTV-QVPPTFENPK---------- 3130

Query: 230  CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
              E  SQ  + GS LVL C   G P P   W K+ +P+
Sbjct: 3131 -TETVSQ--VAGSPLVLTCDVSGVPAPTVTWLKDRMPV 3165



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 42/173 (24%), Positives = 63/173 (36%), Gaps = 38/173 (21%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNG------- 170
            L +L+PP +      +    LAG  V+L C  +G P  Q +W K  + + P G       
Sbjct: 1401 LLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQE 1460

Query: 171  NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
            +   L     HV D G Y C                       +F  +     + +L++ 
Sbjct: 1461 DGQVLRITGSHVGDEGRYQC----------------------VAFSPAGQQARDFQLRVH 1498

Query: 231  VEPT--------SQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLY 275
              PT           +M    + L C A G P P+  WFK+   L   TK +Y
Sbjct: 1499 APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY 1551



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 36/181 (19%), Positives = 69/181 (38%), Gaps = 26/181 (14%)

Query: 134  ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNA-------VHVKDAG 186
            E + ++      L C     P     W++ ++ +  G+   ++          V  ++AG
Sbjct: 2758 EYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAG 2817

Query: 187  FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVL 246
             Y C+ +N    ++  +  L V   P     + + V E  +              ST+ L
Sbjct: 2818 RYSCKASNEVGEDWLHYELL-VLTPPVILGDTEELVEEVTVNA-----------SSTVSL 2865

Query: 247  QCVAVGSPIPHYQWFKNELPLTH-------ETKKLYMVPYVDLEHQGTYWCHVYNDRDSQ 299
            QC A+G+P+P   W +N LP +        E  ++  V   ++    +Y C   N   S 
Sbjct: 2866 QCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925

Query: 300  D 300
            +
Sbjct: 2926 E 2926



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 46/185 (24%), Positives = 70/185 (37%), Gaps = 19/185 (10%)

Query: 119  LQLLSPPGIKITVNPESKA-VLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTSELI 176
            L++  PP  +IT+ P     VL    V+L C ATG P     W K    + P G     +
Sbjct: 1971 LRVNVPP--RITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 2028

Query: 177  FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQ 236
            F        G  V  + +    +  ++S + V  + E  Q  V  V      I  E  + 
Sbjct: 2029 F-------PGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEELNV 2080

Query: 237  KLMPGSTLVLQCVAVGSPIPHYQWFKNELPL-------THETKKLYMVPYVDLEHQGTYW 289
             ++   ++ L+C +   P P   W+K+  PL           K L  V   D+   G Y 
Sbjct: 2081 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT 2140

Query: 290  CHVYN 294
            C   N
Sbjct: 2141 CEALN 2145



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 41/153 (26%), Positives = 59/153 (38%), Gaps = 22/153 (14%)

Query: 119  LQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP-NGNTS---- 173
            L++L PP             +AG+   L C A G P  Q  W K     P +G       
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVL 1258

Query: 174  ---ELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQIC 230
                L   +V   D+G Y C+  N      S+ ++L V  +P S +   DG         
Sbjct: 1259 EEGSLFLASVSPADSGDYECQATNEVG-STSRRAKL-VVYVPPSIRE--DG--------- 1305

Query: 231  VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
                +   M G +L L+C A G P+P   W K+
Sbjct: 1306 -RKANVSGMAGQSLTLECDANGFPVPEIVWLKD 1337



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 39/156 (25%), Positives = 58/156 (37%), Gaps = 32/156 (20%)

Query: 115  HTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEI-PNGNTS 173
            HT       PP + ++VN         Q   L C+A G P     W K    + P     
Sbjct: 3670 HTVPTIRSGPPAVNVSVN---------QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF 3720

Query: 174  ELI------FNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKL 227
            E++         V  +DAG Y+C  +N+   +  Q   L V + P               
Sbjct: 3721 EILPEGSLRIQPVLAQDAGHYLCLASNSAGSD-RQGRDLRVLEPPA-------------- 3765

Query: 228  QICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKN 263
             I   P++  L   +  +L C A GSP P   W+K+
Sbjct: 3766 -IAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKD 3800



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 42/174 (24%), Positives = 60/174 (34%), Gaps = 31/174 (17%)

Query: 138  VLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV---------HVKDAGFY 188
            V  G    L C   G PF +  W K  + +P         +AV          +   G Y
Sbjct: 2174 VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 2233

Query: 189  VCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQC 248
             C  +N      SQ  QL+V   P+     + G  E        PT   ++      L+C
Sbjct: 2234 TCECSN-VVGNSSQDLQLEVHVPPQ-----IAGPREP-------PTQVSVVQDGVATLEC 2280

Query: 249  VAVGSPIPHYQWFKNELP--------LTHETKKLYMVPYVDLEHQGTYWCHVYN 294
             A G P P   W ++  P        L ++ + L+ V      H G Y C   N
Sbjct: 2281 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLH-VERAQAAHTGRYSCVAEN 2333



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 43/172 (25%), Positives = 64/172 (37%), Gaps = 31/172 (18%)

Query: 123  SPPGIKITVNPESKAVLAGQFVKL-CCRATGHPFVQYQWFKMNKEIPNGNTSELIFN-AV 180
            +PP  +I  +  +  VL GQ V L C    G P  +  W K  + +P G+   +  + ++
Sbjct: 883  APP--QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 940

Query: 181  HV-----KDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTS 235
            H+     + AG Y C   N                   S  R V+ V +   +I    T 
Sbjct: 941  HLDRALQEHAGRYSCVATNT----------------AGSQHRDVELVVQVPPRIHPTATH 984

Query: 236  QKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGT 287
                 G    L CVA G P P   W K    LT         P+ ++  +GT
Sbjct: 985  HITNEGVPASLPCVASGVPAPTITWTKETNALTSRG------PHYNVSKEGT 1030



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 14/86 (16%)

Query: 118  VLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMN---------KEIP 168
            +L L S P  +  V P+   V +G  V L C+ATG P    +W +           + +P
Sbjct: 4302 ILVLQSAPVFQ--VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLP 4359

Query: 169  NGNTSELIFNAVHVKDAGFYVCRVNN 194
            +G+   L    V   DAG Y C  +N
Sbjct: 4360 DGS---LWLENVETGDAGTYDCVAHN 4382



 Score = 33.5 bits (75), Expect = 0.81
 Identities = 45/212 (21%), Positives = 76/212 (35%), Gaps = 34/212 (16%)

Query: 112  AMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGN 171
            A+E +  +++ +PP I     P     LA   + L C     P  +  W +    +    
Sbjct: 3567 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDA 3626

Query: 172  TSE-------LIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSE 224
             ++       L   A+   D+G Y C   N      S   ++++  +P            
Sbjct: 3627 HTQFPERGRFLQLQALSTADSGDYSCTARNA-AGSTSVAFRVEIHTVPT----------- 3674

Query: 225  SKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEH 284
                I   P +  +    T +L C A G P P   W K+ +PL   + +  ++P   L  
Sbjct: 3675 ----IRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRI 3730

Query: 285  Q-------GTYWCHVYN----DRDSQDSKKVE 305
            Q       G Y C   N    DR  +D + +E
Sbjct: 3731 QPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE 3762



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 16/69 (23%), Positives = 31/69 (44%), Gaps = 7/69 (10%)

Query: 233  PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLT-------HETKKLYMVPYVDLEHQ 285
            P ++ ++  +++ L+C+A G P P   WFK   P++           ++  +    L   
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDA 1951

Query: 286  GTYWCHVYN 294
            G+Y C   N
Sbjct: 1952 GSYRCVASN 1960



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 51/229 (22%), Positives = 93/229 (40%), Gaps = 29/229 (12%)

Query: 96   MGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESK-AVLAGQFVKLCCRATGHP 154
            + ++G    E S+ +        L++  PP I     P ++ +V+      L C ATG P
Sbjct: 2227 LAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 2286

Query: 155  FVQYQWFKMNKEIPN--GNTSELIFNAVHVKDA-----GFYVCRVNNNFTFEFSQWSQLD 207
                 W +  + +    G   +    ++HV+ A     G Y C V  N      +  +L 
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC-VAENLAGRAERKFELS 2345

Query: 208  VCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPL 267
            V  +P      +D ++     +            S L L C A+G P P  +WF+ E P+
Sbjct: 2346 VL-VPPELIGDLDPLTNITAAL-----------HSPLTLLCEAMGIPPPAIRWFRGEEPV 2393

Query: 268  T--HETKKL---YMVPYVDLEHQ--GTYWCHVYNDR-DSQDSKKVEIII 308
            +   +T  L   +M+     + Q  G Y C   N+  +++ +  VE+++
Sbjct: 2394 SPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV 2442


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,226,408
Number of Sequences: 37866
Number of extensions: 1615387
Number of successful extensions: 6667
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 216
Number of HSP's that attempted gapping in prelim test: 4644
Number of HSP's gapped (non-prelim): 1493
length of query: 813
length of database: 18,247,518
effective HSP length: 111
effective length of query: 702
effective length of database: 14,044,392
effective search space: 9859163184
effective search space used: 9859163184
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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