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Search of human proteins with 27437023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27437023 calcium/calmodulin-dependent protein kinase kinase
2 beta isoform 6 [Homo sapiens]
(490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 986 0.0
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 984 0.0
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 966 0.0
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 964 0.0
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 959 0.0
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 939 0.0
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 939 0.0
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 501 e-142
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 501 e-142
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha... 480 e-135
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 150 3e-36
gi|116256471 SNF1-like kinase [Homo sapiens] 148 1e-35
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 140 3e-33
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 140 3e-33
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 140 3e-33
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 139 8e-33
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 139 8e-33
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 138 1e-32
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 138 1e-32
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 138 1e-32
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 138 1e-32
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 137 2e-32
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 137 2e-32
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 137 2e-32
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 137 2e-32
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 137 2e-32
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 137 2e-32
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 137 2e-32
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 137 2e-32
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 137 2e-32
>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 6 [Homo sapiens]
Length = 490
Score = 986 bits (2550), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480
DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480
Query: 481 ECESLSELKT 490
ECESLSELKT
Sbjct: 481 ECESLSELKT 490
>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 3 [Homo sapiens]
Length = 545
Score = 984 bits (2545), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480
DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480
Query: 481 ECESLSELK 489
ECESLSELK
Sbjct: 481 ECESLSELK 489
>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 5 [Homo sapiens]
Length = 533
Score = 966 bits (2496), Expect = 0.0
Identities = 490/533 (91%), Positives = 490/533 (91%), Gaps = 43/533 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 490
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKT 533
>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 1 [Homo sapiens]
Length = 588
Score = 964 bits (2491), Expect = 0.0
Identities = 489/532 (91%), Positives = 489/532 (91%), Gaps = 43/532 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 489
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 532
>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 4 [Homo sapiens]
Length = 498
Score = 959 bits (2480), Expect = 0.0
Identities = 476/481 (98%), Positives = 479/481 (99%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480
DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ +
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE 480
Query: 481 E 481
+
Sbjct: 481 D 481
>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 939 bits (2426), Expect = 0.0
Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 481
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 939 bits (2426), Expect = 0.0
Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)
Query: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1 MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
Query: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61 GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
DLITRMLDKNPESRIVVPEIK
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480
Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 481
ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 524
>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 501 bits (1290), Expect = e-142
Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
Query: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
ILVK+M+RKRSFGNPFE +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
Query: 466 SLSAPGNLLTKK 477
S+SAPGNLL K+
Sbjct: 473 SMSAPGNLLVKE 484
>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 501 bits (1290), Expect = e-142
Identities = 258/432 (59%), Positives = 323/432 (74%), Gaps = 55/432 (12%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232
Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
+ +GPVMEVP KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412
Query: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
ILVK+M+RKRSFGNPFE +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472
Query: 466 SLSAPGNLLTKK 477
S+SAPGNLL K+
Sbjct: 473 SMSAPGNLLVKE 484
>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
isoform b [Homo sapiens]
Length = 520
Score = 480 bits (1235), Expect = e-135
Identities = 257/467 (55%), Positives = 321/467 (68%), Gaps = 93/467 (19%)
Query: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
Query: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
Query: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Query: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
Query: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIK------------------------------ 441
+P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
Query: 442 -------------ILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 474
ILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 150 bits (378), Expect = 3e-36
Identities = 91/283 (32%), Positives = 149/283 (52%), Gaps = 32/283 (11%)
Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
V++ Y ++ +GKG++ VVKL + T A+K++ K +L
Sbjct: 15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56
Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
+E++Y+E+ I+K LDHP+++KL +V++ + LY+V E G + + +
Sbjct: 57 ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108
Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
L+E +AR F ++ ++Y H +KI+HRD+K NLL+ + +IKIADFG N FK
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
S LL+ G+P + APE + + G LD+W+MGV LY V G PF + L
Sbjct: 169 -SGELLATWCGSPPYAAPEVFEGQQ--YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225
Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
++ P ++ED + LI RML +P R+ + +IK
Sbjct: 226 RQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDPSKRLTIAQIK 266
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 148 bits (374), Expect = 1e-35
Identities = 90/288 (31%), Positives = 150/288 (52%), Gaps = 32/288 (11%)
Query: 155 GMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPR 214
G Q +++ Y ++ +GKG++ VVKLA + T A+K++ K +L
Sbjct: 17 GQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL------------- 63
Query: 215 GTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP 274
+E++Y+E+ ++K L+HP+++KL +V++ +D LY+V E G
Sbjct: 64 -----------DSSNLEKIYREVQLMKLLNHPHIIKLYQVME--TKDMLYIVTEFAKNGE 110
Query: 275 VMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 333
+ + T LSE++AR F ++ +EY H I+HRD+K NLL+ + IK+ADFG
Sbjct: 111 MFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGF 170
Query: 334 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 393
N +K + LS G+P + APE K + G LD+W++GV LY V G PF
Sbjct: 171 GNFYKSGEP-LSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227
Query: 394 RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
+ L ++ P +++D + LI RML +P RI + +I+
Sbjct: 228 NLPTLRQRVLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIR 273
>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
Length = 433
Score = 140 bits (353), Expect = 3e-33
Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%)
Query: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221
+ +Y + D +G+GSYG VK + A+K+L KKKL R P
Sbjct: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
Query: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279
G V +EI +L++L H NV++LV+VL + + +YMV E G +++
Sbjct: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
Query: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338
K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
Query: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397
+D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
Query: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
L I + P D L DL+ ML+ P R + +I+
Sbjct: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 140 bits (352), Expect = 3e-33
Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 35/282 (12%)
Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
+Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54
Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
+++ +E I + L HPN+V+L + + + E H Y++F+LV G + E + +
Sbjct: 55 -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
SE A Q +++ + + H ++HRD+KP NLL+ + +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
GTP +++PE L RK GK +D+WA GV LY + G PF DE L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+IK+ A +F P+ + + KDLI +ML NP RI E
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 140 bits (352), Expect = 3e-33
Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 35/282 (12%)
Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
+Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54
Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
+++ +E I + L HPN+V+L + + + E H Y++F+LV G + E + +
Sbjct: 55 -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105
Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
SE A Q +++ + + H ++HRD+KP NLL+ + +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165
Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
GTP +++PE L RK GK +D+WA GV LY + G PF DE L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222
Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+IK+ A +F P+ + + KDLI +ML NP RI E
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 139 bits (349), Expect = 8e-33
Identities = 90/283 (31%), Positives = 143/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + KDLI +ML NP RI E
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASE 265
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 139 bits (349), Expect = 8e-33
Identities = 90/283 (31%), Positives = 143/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
++Y L +E+GKG++ VV+ YA K+++ KKL +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
+ SE A Q +++ + + H I+HRD+KP NLL+ +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + KDLI +ML NP RI E
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASE 265
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 138 bits (348), Expect = 1e-32
Identities = 104/341 (30%), Positives = 164/341 (48%), Gaps = 35/341 (10%)
Query: 156 MQDCVQLNQ--YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPP 213
M D L + Y L +G+GSY VK AY+E A+K++ +KK
Sbjct: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK------------- 47
Query: 214 RGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG 273
AP ++ P +EI IL L+H +++K E+ + + +Y+V EL QG
Sbjct: 48 -----APADFLEKFLP-----REIEILAMLNHCSIIKTYEIFET-SHGKVYIVMELAVQG 96
Query: 274 PVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 332
++E + T L ED+AR F L I+Y H ++HRD+K NLL+ +D +IK++DF
Sbjct: 97 DLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFS 156
Query: 333 VS----NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQC 388
S + G AL G+PA+ APE L + K D+W++GV LY V G
Sbjct: 157 FSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP--YQPKVYDIWSLGVILYIMVCGSM 214
Query: 389 PFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKILVKTMI 448
P+ D I + K + FP + + KDLI ML + R+ + E IL +
Sbjct: 215 PYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDE--ILSHCWM 272
Query: 449 RKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELK 489
+ ++ G+P +E S L T +P + +S ++L+
Sbjct: 273 QPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLE 313
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 138 bits (347), Expect = 1e-32
Identities = 92/276 (33%), Positives = 137/276 (49%), Gaps = 38/276 (13%)
Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
Y +++ +G G++ V LA A+K + KK L
Sbjct: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----------------------- 68
Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKP 283
RG V EIA+L+++ HPN+V L +V + P+ HLY+ ELV G + + +
Sbjct: 69 --RGKEALVENEIAVLRRISHPNIVALEDVHESPS--HLYLAMELVTGGELFDRIMERGS 124
Query: 284 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKGS 340
+E A ++ + YLH I+HRD+KP NLL ED I ++DFG+S G+
Sbjct: 125 YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN 184
Query: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
+L GTP ++APE L + GKA+DVWA+GV Y + G PF DE L S
Sbjct: 185 --MLGTACGTPGYVAPELLEQKPY---GKAVDVWALGVISYILLCGYPPFYDESDPELFS 239
Query: 401 KIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESR 434
+I + EF P DI+E KD I +L+++P+ R
Sbjct: 240 QILRASYEFDSPFWDDISESAKDFIRHLLERDPQKR 275
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 138 bits (347), Expect = 1e-32
Identities = 92/276 (33%), Positives = 137/276 (49%), Gaps = 38/276 (13%)
Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
Y +++ +G G++ V LA A+K + KK L
Sbjct: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----------------------- 134
Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKP 283
RG V EIA+L+++ HPN+V L +V + P+ HLY+ ELV G + + +
Sbjct: 135 --RGKEALVENEIAVLRRISHPNIVALEDVHESPS--HLYLAMELVTGGELFDRIMERGS 190
Query: 284 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKGS 340
+E A ++ + YLH I+HRD+KP NLL ED I ++DFG+S G+
Sbjct: 191 YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN 250
Query: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
+L GTP ++APE L + GKA+DVWA+GV Y + G PF DE L S
Sbjct: 251 --MLGTACGTPGYVAPELLEQKPY---GKAVDVWALGVISYILLCGYPPFYDESDPELFS 305
Query: 401 KIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESR 434
+I + EF P DI+E KD I +L+++P+ R
Sbjct: 306 QILRASYEFDSPFWDDISESAKDFIRHLLERDPQKR 341
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 138 bits (347), Expect = 1e-32
Identities = 85/286 (29%), Positives = 151/286 (52%), Gaps = 32/286 (11%)
Query: 157 QDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGT 216
Q + Y L+ +GKG G+VKL + A+K+++++KL
Sbjct: 26 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV----------- 74
Query: 217 RPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 276
+ +V +EIAILK ++HP+V+KL +V + N+ +LY+V E V+ G +
Sbjct: 75 -------------LMKVEREIAILKLIEHPHVLKLHDVYE--NKKYLYLVLEHVSGGELF 119
Query: 277 EVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN 335
+ K L+ +AR +F+ ++ +++ H I HRD+KP NLL+ E +I+IADFG+++
Sbjct: 120 DYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS 179
Query: 336 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 395
+ D+LL + G+P + PE + + + G+ D+W+ GV L+ + G PF D+ +
Sbjct: 180 -LQVGDSLLETSCGSPHYACPEVIKGEK--YDGRRADMWSCGVILFALLVGALPFDDDNL 236
Query: 396 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
L K+K P I D + L+ M++ PE R+ + +I+
Sbjct: 237 RQLLEKVKRGVFHMPH--FIPPDCQSLLRGMIEVEPEKRLSLEQIQ 280
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 137 bits (346), Expect = 2e-32
Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)
Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
L +P+ +S+ + S T + + Y L IGKG++ VKLA + A+K+
Sbjct: 24 LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83
Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
+ K +L + ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84 IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119
Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
+ E LY+V E + G V + + E +AR F+ ++ ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
NLL+ D +IKIADFG SNEF + L G+P + APE K + G +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234
Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
++GV LY V G PF + + L ++ P ++ D ++L+ + L NP R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292
Query: 435 IVVPEI 440
+ +I
Sbjct: 293 GTLEQI 298
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 137 bits (346), Expect = 2e-32
Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)
Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
L +P+ +S+ + S T + + Y L IGKG++ VKLA + A+K+
Sbjct: 24 LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83
Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
+ K +L + ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84 IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119
Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
+ E LY+V E + G V + + E +AR F+ ++ ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
NLL+ D +IKIADFG SNEF + L G+P + APE K + G +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234
Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
++GV LY V G PF + + L ++ P ++ D ++L+ + L NP R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292
Query: 435 IVVPEI 440
+ +I
Sbjct: 293 GTLEQI 298
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 137 bits (346), Expect = 2e-32
Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)
Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
L +P+ +S+ + S T + + Y L IGKG++ VKLA + A+K+
Sbjct: 24 LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83
Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
+ K +L + ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84 IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119
Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
+ E LY+V E + G V + + E +AR F+ ++ ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
NLL+ D +IKIADFG SNEF + L G+P + APE K + G +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234
Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
++GV LY V G PF + + L ++ P ++ D ++L+ + L NP R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292
Query: 435 IVVPEI 440
+ +I
Sbjct: 293 GTLEQI 298
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 137 bits (346), Expect = 2e-32
Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)
Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
L +P+ +S+ + S T + + Y L IGKG++ VKLA + A+K+
Sbjct: 24 LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83
Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
+ K +L + ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84 IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119
Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
+ E LY+V E + G V + + E +AR F+ ++ ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
NLL+ D +IKIADFG SNEF + L G+P + APE K + G +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234
Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
++GV LY V G PF + + L ++ P ++ D ++L+ + L NP R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292
Query: 435 IVVPEI 440
+ +I
Sbjct: 293 GTLEQI 298
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 137 bits (346), Expect = 2e-32
Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + K+LI +ML NP RI +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 137 bits (346), Expect = 2e-32
Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + K+LI +ML NP RI +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 137 bits (346), Expect = 2e-32
Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + K+LI +ML NP RI +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 137 bits (346), Expect = 2e-32
Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + K+LI +ML NP RI +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 137 bits (346), Expect = 2e-32
Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)
Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
+ Y L +E+GKG++ VV+ + YA K+++ KKL +
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55
Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
+++ +E I + L HPN+V+L + + + E Y+VF+LV G + E +
Sbjct: 56 --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105
Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
+ SE A +++ + ++H I+HRD+KP NLL+ + +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165
Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
G GTP +++PE L RK GK +D+WA GV LY + G PF DE L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222
Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
+ +IK+ A +F P+ + + K+LI +ML NP RI +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,707,366
Number of Sequences: 37866
Number of extensions: 1019556
Number of successful extensions: 6201
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 3864
Number of HSP's gapped (non-prelim): 1187
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.