Guide to the Human Genome
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Search of human proteins with 27437019

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27437019 calcium/calmodulin-dependent protein kinase kinase
2 beta isoform 4 [Homo sapiens]
         (498 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2...  1003   0.0  
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2...   983   0.0  
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2...   983   0.0  
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2...   959   0.0  
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2...   959   0.0  
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2...   939   0.0  
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2...   939   0.0  
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ...   508   e-144
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ...   508   e-144
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha...   480   e-135
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         150   3e-36
gi|116256471 SNF1-like kinase [Homo sapiens]                          148   1e-35
gi|14042947 testis-specific serine kinase 1 [Homo sapiens]            140   2e-33
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]          140   3e-33
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   140   3e-33
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   140   3e-33
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   139   8e-33
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   139   8e-33
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   138   1e-32
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...   138   1e-32
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               138   1e-32
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   137   2e-32
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   137   2e-32
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   137   2e-32
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   137   2e-32
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   137   2e-32
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   137   2e-32
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   137   2e-32
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   137   2e-32
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma...   137   2e-32

>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 4 [Homo sapiens]
          Length = 498

 Score = 1003 bits (2594), Expect = 0.0
 Identities = 498/498 (100%), Positives = 498/498 (100%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE 480
           DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE 480

Query: 481 DNLQGTDPPPVGEEEVLL 498
           DNLQGTDPPPVGEEEVLL
Sbjct: 481 DNLQGTDPPPVGEEEVLL 498


>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  983 bits (2540), Expect = 0.0
 Identities = 498/541 (92%), Positives = 498/541 (92%), Gaps = 43/541 (7%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 497
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540

Query: 498 L 498
           L
Sbjct: 541 L 541


>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  983 bits (2540), Expect = 0.0
 Identities = 498/541 (92%), Positives = 498/541 (92%), Gaps = 43/541 (7%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 497
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEEVL 540

Query: 498 L 498
           L
Sbjct: 541 L 541


>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 3 [Homo sapiens]
          Length = 545

 Score =  959 bits (2480), Expect = 0.0
 Identities = 476/481 (98%), Positives = 479/481 (99%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE 480
           DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + 
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480

Query: 481 D 481
           +
Sbjct: 481 E 481


>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 6 [Homo sapiens]
          Length = 490

 Score =  959 bits (2480), Expect = 0.0
 Identities = 476/481 (98%), Positives = 479/481 (99%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSE 480
           DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + 
Sbjct: 421 DLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTR 480

Query: 481 D 481
           +
Sbjct: 481 E 481


>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 1 [Homo sapiens]
          Length = 588

 Score =  939 bits (2426), Expect = 0.0
 Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 481
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524


>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 5 [Homo sapiens]
          Length = 533

 Score =  939 bits (2426), Expect = 0.0
 Identities = 476/524 (90%), Positives = 479/524 (91%), Gaps = 43/524 (8%)

Query: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60
           MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
Sbjct: 1   MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP 60

Query: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120
           GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
Sbjct: 61  GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR 120

Query: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180
           CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
Sbjct: 121 CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK 180

Query: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240
           LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
Sbjct: 181 LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL 240

Query: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
           KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
Sbjct: 241 KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300

Query: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360
           EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS 360

Query: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420
           ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
Sbjct: 361 ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK 420

Query: 421 DLITRMLDKNPESRIVVPEIK--------------------------------------- 441
           DLITRMLDKNPESRIVVPEIK                                       
Sbjct: 421 DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS 480

Query: 442 ----ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKQGSED 481
               ILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTK+ + +
Sbjct: 481 LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRE 524


>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  508 bits (1309), Expect = e-144
 Identities = 263/450 (58%), Positives = 332/450 (73%), Gaps = 55/450 (12%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232

Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292

Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352

Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK        
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412

Query: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
                                              ILVK+M+RKRSFGNPFE  +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472

Query: 466 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 495
           S+SAPGNLL K+G  +  +  + P V E+E
Sbjct: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502


>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  508 bits (1309), Expect = e-144
 Identities = 263/450 (58%), Positives = 332/450 (73%), Gaps = 55/450 (12%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 269
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+VF+L
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL 232

Query: 270 VNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIA 329
           + +GPVMEVP  KP SE+QAR Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIA
Sbjct: 233 LRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292

Query: 330 DFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 389
           DFGVSN+F+G+DA LS+T GTPAFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CP
Sbjct: 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 352

Query: 390 FMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK-------- 441
           F+D+ I+ LH KIK++ + FP++P+I+E+LKDLI +MLDKNPE+RI VP+IK        
Sbjct: 353 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN 412

Query: 442 -----------------------------------ILVKTMIRKRSFGNPFE-GSRREER 465
                                              ILVK+M+RKRSFGNPFE  +RREER
Sbjct: 413 GEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREER 472

Query: 466 SLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 495
           S+SAPGNLL K+G  +  +  + P V E+E
Sbjct: 473 SMSAPGNLLVKEGFGEGGKSPELPGVQEDE 502


>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform b [Homo sapiens]
          Length = 520

 Score =  480 bits (1235), Expect = e-135
 Identities = 257/467 (55%), Positives = 321/467 (68%), Gaps = 93/467 (19%)

Query: 90  ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
           ARP LS RKLSLQER      AG  L+          PY+   +   SPR  RRPT+ESH
Sbjct: 64  ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112

Query: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
           HV+I+  +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172

Query: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
           RPPPRG++ A GG  +   P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+    
Sbjct: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232

Query: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
                                             VF+L+ +GPVMEVP  KP SE+QAR 
Sbjct: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292

Query: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
           Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352

Query: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
           AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412

Query: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIK------------------------------ 441
           +P+I+E+LKDLI +MLDKNPE+RI VP+IK                              
Sbjct: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472

Query: 442 -------------ILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 474
                        ILVK+M+RKRSFGNPFE  +RREERS+SAPGNLL
Sbjct: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  150 bits (378), Expect = 3e-36
 Identities = 91/283 (32%), Positives = 149/283 (52%), Gaps = 32/283 (11%)

Query: 160 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 219
           V++  Y ++  +GKG++ VVKL  +    T  A+K++ K +L                  
Sbjct: 15  VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56

Query: 220 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 278
                     +E++Y+E+ I+K LDHP+++KL +V++   +  LY+V E    G + + +
Sbjct: 57  ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLVTEYAKNGEIFDYL 108

Query: 279 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 338
                L+E +AR  F  ++  ++Y H +KI+HRD+K  NLL+  + +IKIADFG  N FK
Sbjct: 109 ANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFK 168

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
            S  LL+   G+P + APE     +  + G  LD+W+MGV LY  V G  PF    +  L
Sbjct: 169 -SGELLATWCGSPPYAAPEVFEGQQ--YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225

Query: 399 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
             ++       P    ++ED + LI RML  +P  R+ + +IK
Sbjct: 226 RQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDPSKRLTIAQIK 266


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  148 bits (374), Expect = 1e-35
 Identities = 90/288 (31%), Positives = 150/288 (52%), Gaps = 32/288 (11%)

Query: 155 GMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPR 214
           G Q  +++  Y ++  +GKG++ VVKLA +    T  A+K++ K +L             
Sbjct: 17  GQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL------------- 63

Query: 215 GTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP 274
                          +E++Y+E+ ++K L+HP+++KL +V++   +D LY+V E    G 
Sbjct: 64  -----------DSSNLEKIYREVQLMKLLNHPHIIKLYQVME--TKDMLYIVTEFAKNGE 110

Query: 275 VMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 333
           + +  T    LSE++AR  F  ++  +EY H   I+HRD+K  NLL+  +  IK+ADFG 
Sbjct: 111 MFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGF 170

Query: 334 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 393
            N +K  +  LS   G+P + APE      K + G  LD+W++GV LY  V G  PF   
Sbjct: 171 GNFYKSGEP-LSTWCGSPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGP 227

Query: 394 RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
            +  L  ++       P    +++D + LI RML  +P  RI + +I+
Sbjct: 228 NLPTLRQRVLEGRFRIPF--FMSQDCESLIRRMLVVDPARRITIAQIR 273


>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
          Length = 367

 Score =  140 bits (354), Expect = 2e-33
 Identities = 106/347 (30%), Positives = 162/347 (46%), Gaps = 35/347 (10%)

Query: 156 MQDCVQLNQ--YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPP 213
           M D   L +  Y L   +G+GSY  VK AY+E      A+K++ +KK             
Sbjct: 1   MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKK------------- 47

Query: 214 RGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG 273
                AP   ++   P     +EI IL  L+H +++K  E+ +  +   +Y+V EL  QG
Sbjct: 48  -----APADFLEKFLP-----REIEILAMLNHCSIIKTYEIFET-SHGKVYIVMELAVQG 96

Query: 274 PVME-VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG 332
            ++E + T   L ED+AR  F  L   I+Y H   ++HRD+K  NLL+ +D +IK++DF 
Sbjct: 97  DLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFS 156

Query: 333 VS----NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQC 388
            S     +  G  AL     G+PA+ APE L      +  K  D+W++GV LY  V G  
Sbjct: 157 FSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP--YQPKVYDIWSLGVILYIMVCGSM 214

Query: 389 PFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKILVKTMI 448
           P+ D  I  +    K   + FP    +  + KDLI  ML  +   R+ + E  IL    +
Sbjct: 215 PYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDE--ILSHCWM 272

Query: 449 RKRSFGNPFEGSRREERSLSAPGNLLTKQGSEDNLQGTDPPPVGEEE 495
           + ++ G+P     +E  S      L T +   D    T   P GE +
Sbjct: 273 QPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQ 319


>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
          Length = 433

 Score =  140 bits (353), Expect = 3e-33
 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%)

Query: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90

Query: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143

Query: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203

Query: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262

Query: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
           L   I   +   P   D    L DL+  ML+  P  R  + +I+
Sbjct: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  140 bits (352), Expect = 3e-33
 Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 35/282 (12%)

Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
           +Y L +E+GKG++ VV+          YA K+++ KKL  +                   
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54

Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
                  +++ +E  I + L HPN+V+L + + +  E H Y++F+LV  G + E +   +
Sbjct: 55  -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
             SE  A    Q +++ + + H   ++HRD+KP NLL+    +   +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
                    GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
            +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  140 bits (352), Expect = 3e-33
 Identities = 89/282 (31%), Positives = 144/282 (51%), Gaps = 35/282 (12%)

Query: 164 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 223
           +Y L +E+GKG++ VV+          YA K+++ KKL  +                   
Sbjct: 12  EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH----------------- 54

Query: 224 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLK 282
                  +++ +E  I + L HPN+V+L + + +  E H Y++F+LV  G + E +   +
Sbjct: 55  -------QKLEREARICRLLKHPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVARE 105

Query: 283 PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKG 339
             SE  A    Q +++ + + H   ++HRD+KP NLL+    +   +K+ADFG++ E +G
Sbjct: 106 YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG 165

Query: 340 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH 399
                    GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L+
Sbjct: 166 EQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLY 222

Query: 400 SKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
            +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E
Sbjct: 223 QQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  139 bits (349), Expect = 8e-33
 Identities = 90/283 (31%), Positives = 143/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASE 265


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  139 bits (349), Expect = 8e-33
 Identities = 90/283 (31%), Positives = 143/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           ++Y L +E+GKG++ VV+          YA K+++ KKL  +                  
Sbjct: 12  DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGH---IKIADFGVSNEFK 338
           +  SE  A    Q +++ + + H   I+HRD+KP NLL+        +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GDQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + KDLI +ML  NP  RI   E
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASE 265


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  138 bits (347), Expect = 1e-32
 Identities = 92/276 (33%), Positives = 137/276 (49%), Gaps = 38/276 (13%)

Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
           Y +++ +G G++  V LA         A+K + KK L                       
Sbjct: 32  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----------------------- 68

Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKP 283
             RG    V  EIA+L+++ HPN+V L +V + P+  HLY+  ELV  G + + +     
Sbjct: 69  --RGKEALVENEIAVLRRISHPNIVALEDVHESPS--HLYLAMELVTGGELFDRIMERGS 124

Query: 284 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKGS 340
            +E  A      ++  + YLH   I+HRD+KP NLL     ED  I ++DFG+S    G+
Sbjct: 125 YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN 184

Query: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
             +L    GTP ++APE L +      GKA+DVWA+GV  Y  + G  PF DE    L S
Sbjct: 185 --MLGTACGTPGYVAPELLEQKPY---GKAVDVWALGVISYILLCGYPPFYDESDPELFS 239

Query: 401 KIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESR 434
           +I   + EF  P   DI+E  KD I  +L+++P+ R
Sbjct: 240 QILRASYEFDSPFWDDISESAKDFIRHLLERDPQKR 275


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score =  138 bits (347), Expect = 1e-32
 Identities = 92/276 (33%), Positives = 137/276 (49%), Gaps = 38/276 (13%)

Query: 165 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 224
           Y +++ +G G++  V LA         A+K + KK L                       
Sbjct: 98  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----------------------- 134

Query: 225 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKP 283
             RG    V  EIA+L+++ HPN+V L +V + P+  HLY+  ELV  G + + +     
Sbjct: 135 --RGKEALVENEIAVLRRISHPNIVALEDVHESPS--HLYLAMELVTGGELFDRIMERGS 190

Query: 284 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFKGS 340
            +E  A      ++  + YLH   I+HRD+KP NLL     ED  I ++DFG+S    G+
Sbjct: 191 YTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN 250

Query: 341 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 400
             +L    GTP ++APE L +      GKA+DVWA+GV  Y  + G  PF DE    L S
Sbjct: 251 --MLGTACGTPGYVAPELLEQKPY---GKAVDVWALGVISYILLCGYPPFYDESDPELFS 305

Query: 401 KIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESR 434
           +I   + EF  P   DI+E  KD I  +L+++P+ R
Sbjct: 306 QILRASYEFDSPFWDDISESAKDFIRHLLERDPQKR 341


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  138 bits (347), Expect = 1e-32
 Identities = 85/286 (29%), Positives = 151/286 (52%), Gaps = 32/286 (11%)

Query: 157 QDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGT 216
           Q    +  Y L+  +GKG  G+VKL  +       A+K+++++KL               
Sbjct: 26  QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV----------- 74

Query: 217 RPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 276
                        + +V +EIAILK ++HP+V+KL +V +  N+ +LY+V E V+ G + 
Sbjct: 75  -------------LMKVEREIAILKLIEHPHVLKLHDVYE--NKKYLYLVLEHVSGGELF 119

Query: 277 EVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSN 335
           +    K  L+  +AR +F+ ++  +++ H   I HRD+KP NLL+ E  +I+IADFG+++
Sbjct: 120 DYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS 179

Query: 336 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 395
             +  D+LL  + G+P +  PE +   +  + G+  D+W+ GV L+  + G  PF D+ +
Sbjct: 180 -LQVGDSLLETSCGSPHYACPEVIKGEK--YDGRRADMWSCGVILFALLVGALPFDDDNL 236

Query: 396 MCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441
             L  K+K      P    I  D + L+  M++  PE R+ + +I+
Sbjct: 237 RQLLEKVKRGVFHMPH--FIPPDCQSLLRGMIEVEPEKRLSLEQIQ 280


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  137 bits (346), Expect = 2e-32
 Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)

Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
           L  +P+ +S+ +    S T   +   +  Y L   IGKG++  VKLA +       A+K+
Sbjct: 24  LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83

Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
           + K +L   +                        ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84  IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119

Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
           +   E  LY+V E  + G V +       + E +AR  F+ ++  ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
             NLL+  D +IKIADFG SNEF   +  L    G+P + APE      K + G  +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234

Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
           ++GV LY  V G  PF  + +  L  ++       P    ++ D ++L+ + L  NP  R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292

Query: 435 IVVPEI 440
             + +I
Sbjct: 293 GTLEQI 298


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  137 bits (346), Expect = 2e-32
 Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)

Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
           L  +P+ +S+ +    S T   +   +  Y L   IGKG++  VKLA +       A+K+
Sbjct: 24  LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83

Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
           + K +L   +                        ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84  IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119

Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
           +   E  LY+V E  + G V +       + E +AR  F+ ++  ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
             NLL+  D +IKIADFG SNEF   +  L    G+P + APE      K + G  +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234

Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
           ++GV LY  V G  PF  + +  L  ++       P    ++ D ++L+ + L  NP  R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292

Query: 435 IVVPEI 440
             + +I
Sbjct: 293 GTLEQI 298


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  137 bits (346), Expect = 2e-32
 Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)

Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
           L  +P+ +S+ +    S T   +   +  Y L   IGKG++  VKLA +       A+K+
Sbjct: 24  LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83

Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
           + K +L   +                        ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84  IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119

Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
           +   E  LY+V E  + G V +       + E +AR  F+ ++  ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
             NLL+  D +IKIADFG SNEF   +  L    G+P + APE      K + G  +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234

Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
           ++GV LY  V G  PF  + +  L  ++       P    ++ D ++L+ + L  NP  R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292

Query: 435 IVVPEI 440
             + +I
Sbjct: 293 GTLEQI 298


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  137 bits (346), Expect = 2e-32
 Identities = 92/306 (30%), Positives = 153/306 (50%), Gaps = 36/306 (11%)

Query: 140 LPRRPTVESHHV----SITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKV 195
           L  +P+ +S+ +    S T   +   +  Y L   IGKG++  VKLA +       A+K+
Sbjct: 24  LDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKI 83

Query: 196 LSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVL 255
           + K +L   +                        ++++++E+ I+K L+HPN+VKL EV+
Sbjct: 84  IDKTQLNSSS------------------------LQKLFREVRIMKVLNHPNIVKLFEVI 119

Query: 256 DDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYLHYQKIIHRDIK 314
           +   E  LY+V E  + G V +       + E +AR  F+ ++  ++Y H + I+HRD+K
Sbjct: 120 E--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177

Query: 315 PSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVW 374
             NLL+  D +IKIADFG SNEF   +  L    G+P + APE      K + G  +DVW
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTFGNK-LDTFCGSPPYAAPELFQ--GKKYDGPEVDVW 234

Query: 375 AMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 434
           ++GV LY  V G  PF  + +  L  ++       P    ++ D ++L+ + L  NP  R
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY--MSTDCENLLKKFLILNPSKR 292

Query: 435 IVVPEI 440
             + +I
Sbjct: 293 GTLEQI 298


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  137 bits (346), Expect = 2e-32
 Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  137 bits (346), Expect = 2e-32
 Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  137 bits (346), Expect = 2e-32
 Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  137 bits (346), Expect = 2e-32
 Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265


>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
           isoform 2 [Homo sapiens]
          Length = 527

 Score =  137 bits (346), Expect = 2e-32
 Identities = 87/283 (30%), Positives = 144/283 (50%), Gaps = 35/283 (12%)

Query: 163 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 222
           + Y L +E+GKG++ VV+    +     YA K+++ KKL  +                  
Sbjct: 12  DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDH---------------- 55

Query: 223 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 281
                   +++ +E  I + L HPN+V+L + + +  E   Y+VF+LV  G + E +   
Sbjct: 56  --------QKLEREARICRLLKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAR 105

Query: 282 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG---EDGHIKIADFGVSNEFK 338
           +  SE  A      +++ + ++H   I+HRD+KP NLL+    +   +K+ADFG++ E +
Sbjct: 106 EYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ 165

Query: 339 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 398
           G         GTP +++PE L   RK   GK +D+WA GV LY  + G  PF DE    L
Sbjct: 166 GEQQAWFGFAGTPGYLSPEVL---RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKL 222

Query: 399 HSKIKSQALEF--PDQPDIAEDLKDLITRMLDKNPESRIVVPE 439
           + +IK+ A +F  P+   +  + K+LI +ML  NP  RI   +
Sbjct: 223 YQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQ 265


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,665,897
Number of Sequences: 37866
Number of extensions: 1080568
Number of successful extensions: 6351
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 4009
Number of HSP's gapped (non-prelim): 1195
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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