BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|27437008 kringle-containing transmembrane protein 2 isoform d precursor [Homo sapiens] (462 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|27437008 kringle-containing transmembrane protein 2 isoform d... 970 0.0 gi|13375642 kringle-containing transmembrane protein 2 isoform b... 788 0.0 gi|227116325 kringle-containing transmembrane protein 1 isoform ... 328 6e-90 gi|24041012 kringle-containing transmembrane protein 1 isoform 2... 327 1e-89 gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi... 83 6e-16 gi|4505861 plasminogen activator, tissue isoform 1 preproprotein... 79 9e-15 gi|14702169 plasminogen activator, tissue isoform 3 preproprotei... 79 9e-15 gi|145275213 coagulation factor XII precursor [Homo sapiens] 75 2e-13 gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] 72 1e-12 gi|22035663 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] 69 7e-12 gi|13346502 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] 69 7e-12 gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 69 7e-12 gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 69 7e-12 gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 69 7e-12 gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 65 1e-10 gi|4504383 HGF activator preproprotein [Homo sapiens] 65 1e-10 gi|4505881 plasminogen [Homo sapiens] 65 1e-10 gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-... 65 1e-10 gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 64 2e-10 gi|54792094 WSC domain containing 1 [Homo sapiens] 62 8e-10 gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo s... 61 2e-09 gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo s... 61 2e-09 gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo s... 61 2e-09 gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Ho... 61 2e-09 gi|55749667 WSC domain containing 2 [Homo sapiens] 61 2e-09 gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa... 60 4e-09 gi|4505863 plasminogen activator, urokinase isoform 1 preproprot... 60 4e-09 gi|4503635 coagulation factor II preproprotein [Homo sapiens] 60 5e-09 gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 57 4e-08 gi|126091152 cubilin [Homo sapiens] 57 4e-08 >gi|27437008 kringle-containing transmembrane protein 2 isoform d precursor [Homo sapiens] Length = 462 Score = 970 bits (2508), Expect = 0.0 Identities = 462/462 (100%), Positives = 462/462 (100%) Query: 1 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC 60 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC Sbjct: 1 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC 60 Query: 61 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH 120 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH Sbjct: 61 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH 120 Query: 121 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL 180 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL Sbjct: 121 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL 180 Query: 181 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG 240 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG Sbjct: 181 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG 240 Query: 241 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG 300 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG Sbjct: 241 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG 300 Query: 301 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA 360 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA Sbjct: 301 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA 360 Query: 361 PPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPGKGPPALGASRGPRRSWAVWY 420 PPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPGKGPPALGASRGPRRSWAVWY Sbjct: 361 PPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPGKGPPALGASRGPRRSWAVWY 420 Query: 421 QQPRGVALPCSPGDPQAEGSAAGYRPLSASSQSSLRSLISAL 462 QQPRGVALPCSPGDPQAEGSAAGYRPLSASSQSSLRSLISAL Sbjct: 421 QQPRGVALPCSPGDPQAEGSAAGYRPLSASSQSSLRSLISAL 462 >gi|13375642 kringle-containing transmembrane protein 2 isoform b precursor [Homo sapiens] Length = 420 Score = 788 bits (2034), Expect = 0.0 Identities = 380/436 (87%), Positives = 382/436 (87%), Gaps = 26/436 (5%) Query: 1 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC 60 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC Sbjct: 1 MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPC 60 Query: 61 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH 120 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH Sbjct: 61 LFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCH 120 Query: 121 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL 180 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL Sbjct: 121 MPGYLGCFVDSGAPPALSGPSGTSTKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDL 180 Query: 181 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG 240 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG Sbjct: 181 ARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYG 240 Query: 241 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG 300 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG Sbjct: 241 PDRNCSWALGPPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG 300 Query: 301 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA 360 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA Sbjct: 301 TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGA 360 Query: 361 PPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPGKGPPALGASRGPRRSWAVWY 420 PPAAIG V C L KGP G P + Sbjct: 361 PPAAIGGAV-------------------------CWLRE-KGPRRWGLPGAPGEAGLCGT 394 Query: 421 QQPRGVALPCSPGDPQ 436 P G P PG P+ Sbjct: 395 NSPEGWPCPAPPGTPR 410 >gi|227116325 kringle-containing transmembrane protein 1 isoform 3 precursor [Homo sapiens] Length = 458 Score = 328 bits (841), Expect = 6e-90 Identities = 172/379 (45%), Positives = 234/379 (61%), Gaps = 31/379 (8%) Query: 30 SPGLS---ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAH 86 SPGL ECF NGADYRG QN T +G G+PCLFW++T QH Y++ P+G GLG H Sbjct: 25 SPGLGPGPECFTANGADYRGTQNWTALQG-GKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 Query: 87 NFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTK 146 N+CRNPDGDV PWCYVAE E+G+YW+YC+IP+C MPG LGC+ D G PP L+G S TS K Sbjct: 84 NYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNK 143 Query: 147 LTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGD 206 LT+Q C+ FCR + ++ AG+E+GYACFCG+ D + A +T+C+ +CFG Q CGGD Sbjct: 144 LTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGD 203 Query: 207 GRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAA-LELTFRLFEL 265 GR+ +++ VG+C GN++A V+YSPDFPD Y R C W + PGA+ + +F LF++ Sbjct: 204 GRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDI 263 Query: 266 ADPRDRLELRDAASGSLLRAFDG-ARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 D D +EL D + +L F G +RPP S + ++L F SD AQGFA+ Y+ Sbjct: 264 RDSADMVELLDGYTHRVLARFHGRSRPPLS--FNVSLDFVILYFFSDRINQAQGFAVLYQ 321 Query: 325 GLQDAAEDPEAPEGSAQTPAAPL-DGANVSCS------------PRPGAPPAAI-GARVF 370 +++ E P+ QT A + + AN+S S P PP + G V+ Sbjct: 322 AVKE--ELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGWTVY 379 Query: 371 S-------TVTAVSVLLLL 382 TVTA+ +LL Sbjct: 380 GLATLLILTVTAIVAKILL 398 >gi|24041012 kringle-containing transmembrane protein 1 isoform 2 precursor [Homo sapiens] Length = 492 Score = 327 bits (839), Expect = 1e-89 Identities = 161/332 (48%), Positives = 219/332 (65%), Gaps = 11/332 (3%) Query: 30 SPGLS---ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAH 86 SPGL ECF NGADYRG QN T +G G+PCLFW++T QH Y++ P+G GLG H Sbjct: 25 SPGLGPGPECFTANGADYRGTQNWTALQG-GKPCLFWNETFQHPYNTLKYPNGEGGLGEH 83 Query: 87 NFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTK 146 N+CRNPDGDV PWCYVAE E+G+YW+YC+IP+C MPG LGC+ D G PP L+G S TS K Sbjct: 84 NYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNK 143 Query: 147 LTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPGQLCGGD 206 LT+Q C+ FCR + ++ AG+E+GYACFCG+ D + A +T+C+ +CFG Q CGGD Sbjct: 144 LTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGD 203 Query: 207 GRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAA-LELTFRLFEL 265 GR+ +++ VG+C GN++A V+YSPDFPD Y R C W + PGA+ + +F LF++ Sbjct: 204 GRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDI 263 Query: 266 ADPRDRLELRDAASGSLLRAFDG-ARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 D D +EL D + +L F G +RPP S + ++L F SD AQGFA+ Y+ Sbjct: 264 RDSADMVELLDGYTHRVLARFHGRSRPPLS--FNVSLDFVILYFFSDRINQAQGFAVLYQ 321 Query: 325 GLQDAAEDPEAPEGSAQTPAAPL-DGANVSCS 355 +++ E P+ QT A + + AN+S S Sbjct: 322 AVKE--ELPQERPAVNQTVAEVITEQANLSVS 351 >gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapiens] Length = 560 Score = 82.8 bits (203), Expect = 6e-16 Identities = 35/90 (38%), Positives = 52/90 (57%), Gaps = 5/90 (5%) Query: 32 GLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQ--TQQHSYSSASDPHGRWGLGAHNFC 89 G +C+ +G YRG NRT + A CL+W+ Q +Y+ + G+G HNFC Sbjct: 190 GSDDCYVGDGYSYRGKMNRTVNQHA---CLYWNSHLLLQENYNMFMEDAETHGIGEHNFC 246 Query: 90 RNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 RNPD D +PWC++ T + + W YCD+ +C Sbjct: 247 RNPDADEKPWCFIKVTNDKVKWEYCDVSAC 276 >gi|4505861 plasminogen activator, tissue isoform 1 preproprotein [Homo sapiens] Length = 562 Score = 79.0 bits (193), Expect = 9e-15 Identities = 39/96 (40%), Positives = 54/96 (56%), Gaps = 6/96 (6%) Query: 30 SPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHS--YSSASDPHGRWGLGAHN 87 S G S+C+ NG+ YRG + T +G CL W+ Y++ + GLG HN Sbjct: 209 SEGNSDCYFGNGSAYRGTHSLTE---SGASCLPWNSMILIGKVYTAQNPSAQALGLGKHN 265 Query: 88 FCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPG 123 +CRNPDGD +PWC+V + + W YCD+PSC G Sbjct: 266 YCRNPDGDAKPWCHVLKNRR-LTWEYCDVPSCSTCG 300 Score = 62.4 bits (150), Expect = 8e-10 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 9/117 (7%) Query: 20 PRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQ--QHSYSSASDP 77 P G + + C++ G YRG + +G C W+ + Q YS Sbjct: 111 PEGFAGKCCEIDTRATCYEDQGISYRGTWSTAE---SGAECTNWNSSALAQKPYSGRRPD 167 Query: 78 HGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIY-WRYCDIPSCHMPGYLGCFVDSGA 133 R GLG HN+CRNPD D +PWCYV + G Y +C P+C G C+ +G+ Sbjct: 168 AIRLGLGNHNYCRNPDRDSKPWCYVFKA--GKYSSEFCSTPAC-SEGNSDCYFGNGS 221 >gi|14702169 plasminogen activator, tissue isoform 3 preproprotein [Homo sapiens] Length = 516 Score = 79.0 bits (193), Expect = 9e-15 Identities = 39/96 (40%), Positives = 54/96 (56%), Gaps = 6/96 (6%) Query: 30 SPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHS--YSSASDPHGRWGLGAHN 87 S G S+C+ NG+ YRG + T +G CL W+ Y++ + GLG HN Sbjct: 163 SEGNSDCYFGNGSAYRGTHSLTE---SGASCLPWNSMILIGKVYTAQNPSAQALGLGKHN 219 Query: 88 FCRNPDGDVQPWCYVAETEEGIYWRYCDIPSCHMPG 123 +CRNPDGD +PWC+V + + W YCD+PSC G Sbjct: 220 YCRNPDGDAKPWCHVLKNRR-LTWEYCDVPSCSTCG 254 Score = 62.4 bits (150), Expect = 8e-10 Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 9/117 (7%) Query: 20 PRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQ--QHSYSSASDP 77 P G + + C++ G YRG + +G C W+ + Q YS Sbjct: 65 PEGFAGKCCEIDTRATCYEDQGISYRGTWSTAE---SGAECTNWNSSALAQKPYSGRRPD 121 Query: 78 HGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIY-WRYCDIPSCHMPGYLGCFVDSGA 133 R GLG HN+CRNPD D +PWCYV + G Y +C P+C G C+ +G+ Sbjct: 122 AIRLGLGNHNYCRNPDRDSKPWCYVFKA--GKYSSEFCSTPAC-SEGNSDCYFGNGS 175 >gi|145275213 coagulation factor XII precursor [Homo sapiens] Length = 615 Score = 74.7 bits (182), Expect = 2e-13 Identities = 38/108 (35%), Positives = 51/108 (47%), Gaps = 14/108 (12%) Query: 34 SECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGR-WGLGAHNFCRNP 92 + C+ G YRG T +G PC W + +Y + + R WGLG H FCRNP Sbjct: 215 ASCYDGRGLSYRGLARTTL---SGAPCQPW--ASEATYRNVTAEQARNWGLGGHAFCRNP 269 Query: 93 DGDVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGP 140 D D++PWC+V + + W YCD+ C P APP P Sbjct: 270 DNDIRPWCFVLNRDR-LSWEYCDLAQCQTP-------TQAAPPTPVSP 309 >gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] Length = 2040 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 121 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 177 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 178 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 219 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 235 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 291 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 292 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 333 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 349 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 405 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 406 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 447 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 463 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 519 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 520 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 561 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 577 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 633 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 634 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 675 Score = 71.6 bits (174), Expect = 1e-12 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 691 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 747 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 748 PEYYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 789 Score = 70.9 bits (172), Expect = 2e-12 Identities = 33/108 (30%), Positives = 53/108 (49%), Gaps = 6/108 (5%) Query: 12 LLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSY 71 ++ P L+ A + +PG+ +C+ G YRG + T GR C W H + Sbjct: 1030 VILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTV---TGRTCQAWSSMTPHQH 1086 Query: 72 SSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 S + + GL N+CRNPD +++PWCY + + W YC++ C Sbjct: 1087 SRTPENYPNAGL-TRNYCRNPDAEIRPWCYT--MDPSVRWEYCNLTQC 1131 Score = 70.9 bits (172), Expect = 2e-12 Identities = 32/104 (30%), Positives = 50/104 (48%), Gaps = 6/104 (5%) Query: 16 PLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSAS 75 P + A + SPG+ +C+ +G YRG + T GR C W H + + Sbjct: 1148 PSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTV---TGRTCQSWSSMTPHWHQRTT 1204 Query: 76 DPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD ++ PWCY + + W YC++ C Sbjct: 1205 EYYPNGGL-TRNYCRNPDAEISPWCYT--MDPNVRWEYCNLTQC 1245 Score = 69.3 bits (168), Expect = 7e-12 Identities = 36/105 (34%), Positives = 49/105 (46%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG Y+G T GR C W HS+S Sbjct: 919 IPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITV---TGRTCQAWSSMTPHSHSRT 975 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + GL N+CRNPD PWCY T+ + W YC++ C Sbjct: 976 PAYYPNAGL-IKNYCRNPDPVAAPWCYT--TDPSVRWEYCNLTRC 1017 Score = 68.6 bits (166), Expect = 1e-11 Identities = 35/105 (33%), Positives = 50/105 (47%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P L+ A + PG+ EC+ NG YRG + T GR C W HS+S Sbjct: 805 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTT---VTGRTCQAWSSMTPHSHSRT 861 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD P+CY + + W YC++ C Sbjct: 862 PEYYPNAGL-IMNYCRNPDPVAAPYCYT--RDPSVRWEYCNLTQC 903 Score = 67.0 bits (162), Expect = 3e-11 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 6/90 (6%) Query: 30 SPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFC 89 SP + +C+ +G YRG + T GR C W H + ++ + GL N+C Sbjct: 1268 SPTVQDCYHGDGQSYRGSFSTTV---TGRTCQSWSSMTPHWHQRTTEYYPNGGL-TRNYC 1323 Query: 90 RNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 RNPD +++PWCY + + W YC++ C Sbjct: 1324 RNPDAEIRPWCYT--MDPSVRWEYCNLTQC 1351 Score = 67.0 bits (162), Expect = 3e-11 Identities = 35/94 (37%), Positives = 45/94 (47%), Gaps = 6/94 (6%) Query: 27 SLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAH 86 SL P +C NG YRG + T G PC W + H +S+ +W Sbjct: 1711 SLGPPSEQDCMFGNGKGYRGKKATTV---TGTPCQEWAAQEPHRHSTFIPGTNKWAGLEK 1767 Query: 87 NFCRNPDGDVQ-PWCYVAETEEGIYWRYCDIPSC 119 N+CRNPDGD+ PWCY + + YCDIP C Sbjct: 1768 NYCRNPDGDINGPWCYTMNPRK--LFDYCDIPLC 1799 Score = 66.6 bits (161), Expect = 4e-11 Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P ++ +A + +P + +C+ NG YRG + T GR C W H + Sbjct: 1595 VPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTV---TGRTCQSWSSMTPHRHQRT 1651 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + + GL N+CRNPD D PWC+ + I W YC++ C Sbjct: 1652 PENYPNDGL-TMNYCRNPDADTGPWCFT--MDPSIRWEYCNLTRC 1693 Score = 65.1 bits (157), Expect = 1e-10 Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 6/90 (6%) Query: 30 SPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFC 89 SP + +C+ +G YRG + T GR C W H + + + GL N+C Sbjct: 1496 SPVVQDCYHGDGRSYRGISSTTV---TGRTCQSWSSMIPHWHQRTPENYPNAGL-TENYC 1551 Query: 90 RNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 RNPD QPWCY T+ + W YC++ C Sbjct: 1552 RNPDSGKQPWCYT--TDPCVRWEYCNLTQC 1579 Score = 63.2 bits (152), Expect = 5e-10 Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 6/105 (5%) Query: 15 LPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSA 74 +P + A + +S G+ +C++ +G YRG + T GR C W H + Sbjct: 1367 VPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTI---TGRTCQSWSSMTPHWHRRI 1423 Query: 75 SDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 + GL N+CRNPD +++PWCY + + W YC++ C Sbjct: 1424 PLYYPNAGL-TRNYCRNPDAEIRPWCYT--MDPSVRWEYCNLTRC 1465 Score = 61.6 bits (148), Expect = 1e-09 Identities = 35/110 (31%), Positives = 51/110 (46%), Gaps = 13/110 (11%) Query: 10 LFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQH 69 L LLFL SA S + +C+ +G YRG + T GR C W H Sbjct: 9 LLLLFLK-------SAAPEQSHVVQDCYHGDGQSYRGTYSTTV---TGRTCQAWSSMTPH 58 Query: 70 SYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 ++ ++ + GL N+CRNPD P+CY + G+ W YC++ C Sbjct: 59 QHNRTTENYPNAGL-IMNYCRNPDAVAAPYCYT--RDPGVRWEYCNLTQC 105 >gi|22035663 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] Length = 132 Score = 69.3 bits (168), Expect = 7e-12 Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 13/110 (11%) Query: 10 LFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQH 69 L LLFL SA + P + EC+ NG YRG T GR C W H Sbjct: 9 LLLLFLK-------SAPTETGPSVQECYHSNGQSYRGTYFTTV---TGRTCQAWSSMTPH 58 Query: 70 SYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 +S + + GL N+CRNPD PWCY T+ + W YC++ C Sbjct: 59 QHSRTPEKYPNDGL-ISNYCRNPDCSAGPWCYT--TDPNVRWEYCNLTRC 105 >gi|13346502 lipoprotein, Lp(a)-like 2 precursor [Homo sapiens] Length = 132 Score = 69.3 bits (168), Expect = 7e-12 Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 13/110 (11%) Query: 10 LFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQH 69 L LLFL SA + P + EC+ NG YRG T GR C W H Sbjct: 9 LLLLFLK-------SAPTETGPSVQECYHSNGQSYRGTYFTTV---TGRTCQAWSSMTPH 58 Query: 70 SYSSASDPHGRWGLGAHNFCRNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 +S + + GL N+CRNPD PWCY T+ + W YC++ C Sbjct: 59 QHSRTPEKYPNDGL-ISNYCRNPDCSAGPWCYT--TDPNVRWEYCNLTRC 105 >gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens] Length = 3667 Score = 69.3 bits (168), Expect = 7e-12 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 6/127 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRL 272 + + C N+TAP G + SPD+P+ YG + NC W + PG+ + L+F F+L D L Sbjct: 676 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFL 735 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDA 329 ++D S +L F GA P L + L L F++D +GF +TY + Sbjct: 736 AVKDGDSPESPILGTFTGAEVP--SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 793 Query: 330 AEDPEAP 336 DP P Sbjct: 794 CPDPGIP 800 Score = 55.1 bits (131), Expect = 1e-07 Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRDA 277 C G+++AP GVI SP +P Y NC W + PG ++++TF F+ D LE+ D Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDG 914 Query: 278 AS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 + LL +++G + P L + + L F +D GF + Y + Sbjct: 915 PNLLSPLLGSYNGTQVPQF--LFSSSNFIYLLFTTDNSRSNNGFKIHYESV 963 Score = 53.9 bits (128), Expect = 3e-07 Identities = 32/109 (29%), Positives = 53/109 (48%), Gaps = 5/109 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD 276 +C G G+I SP FP+EY + +C+W + PG + L F F++ + D LE+ Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG 259 Query: 277 AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG 325 + ++ G PP P+ L L F +D+ +GF+ Y+G Sbjct: 260 SEPPTIW--LSGMNIPP--PIISNKNWLRLHFVTDSNHRYRGFSAPYQG 304 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 V + C GN T G I SP+FP Y R+C W + + L F F + D L Sbjct: 1543 VCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFL 1602 Query: 273 ELRDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG-LQDA 329 + D ++ L+ +F ++ P + + + L FRSD GF L Y+ L+++ Sbjct: 1603 YIYDGPDSNSPLIGSFQDSKLPER--IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1660 Query: 330 AEDP 333 DP Sbjct: 1661 CFDP 1664 Score = 50.8 bits (120), Expect = 3e-06 Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 + + C G + GVI SP FP Y +C+W + P G + L F F D L Sbjct: 2066 ICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYL 2125 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DA 329 E+R +S +++ G + P S L T L F SD + QGF + Y+ Q + Sbjct: 2126 EVRSGSSETSTVIGRLSGPQIPSS--LFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2183 Query: 330 AEDP 333 DP Sbjct: 2184 CPDP 2187 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 4/123 (3%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G+ P G I SP +P+ Y NC+W + G ++ F F L D D L + + Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1086 Query: 278 ASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAEDPE 334 S + L R PP G L F SD +GF +T+ + EDP Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1146 Query: 335 APE 337 P+ Sbjct: 1147 IPQ 1149 Score = 48.9 bits (115), Expect = 1e-05 Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 6/122 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G T +G I SP +P+ Y + NC W + P GA +++ F D L+ D Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1958 Query: 278 ASGSL--LRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDAAEDPE 334 + L ++ G P L + L L F+SD A GF L Y + D+ +P+ Sbjct: 1959 GDNNAPRLGSYSGTTIPHL--LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQ 2016 Query: 335 AP 336 P Sbjct: 2017 TP 2018 Score = 47.0 bits (110), Expect = 4e-05 Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 10/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 V C + T +G++ SP++P Y + C +++ G + ++ R F LA D L++ Sbjct: 1198 VAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQ-GDVLKI 1256 Query: 275 RDAASGS--LLRAFDGARPPPSGPLRLGTAA--LLLTFRSDARGHAQGFALTYRGLQ-DA 329 D + LL AF GA L L + + L L F SD G +GF L Y + Sbjct: 1257 YDGKDKTTHLLGAFTGA---SMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313 Query: 330 AEDPEAPE 337 EDP P+ Sbjct: 1314 CEDPGIPQ 1321 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 6/126 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C GN TA G IYSP +PDEY ++C W + PPG + + F + + D + + D Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2302 Query: 278 --ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEA 335 + + F G S + + +L+ F SD + F L+Y Q P Sbjct: 2303 PDQNSPQIGQFSGNTALES--VYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPPP 2359 Query: 336 PEGSAQ 341 P +A+ Sbjct: 2360 PVPNAE 2365 Score = 41.6 bits (96), Expect = 0.002 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 8/131 (6%) Query: 202 LCGGDGRLGVYEVSVGSCQG----NWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALE 257 + G DGR G + ++ SC T +G + SP++P Y NC +++ P + Sbjct: 1702 IMGDDGRPG-WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1760 Query: 258 LTFRLFELADPRDRLELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGH 315 +F D +E+ D + SLL + G+ S PL G + + F S Sbjct: 1761 FGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGN-QITIRFTSVGPIT 1819 Query: 316 AQGFALTYRGL 326 A+GF Y+ + Sbjct: 1820 AKGFHFVYQAV 1830 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 5/116 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRLELRD 276 +C G G I SP FP Y NC+W + +++ F+ F L + D L L D Sbjct: 24 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYD 83 Query: 277 A--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAA 330 + G PP P+ + L SD A GF + Y LQ ++ Sbjct: 84 GHPHPTNFRTRLTGFHLPP--PVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS 137 Score = 39.7 bits (91), Expect = 0.006 Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 9/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGP--PGAALELTFRLFELADPRDRLE 273 V +C N P G SP+FP +Y + C W + +++ F F+L D L Sbjct: 505 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 564 Query: 274 LRDAAS----GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-D 328 + D ++L+ G+ P + ++ + L ++D + GF + Y+ ++ + Sbjct: 565 IGDGGEVGDPRTVLQVLTGSFVPDL--IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 622 Query: 329 AAEDPEAP 336 + DP P Sbjct: 623 SCGDPGTP 630 Score = 29.3 bits (64), Expect = 7.9 Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 228 GVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRD 276 GVI SP +PD Y + C+W++ G + + F+ D L++ D Sbjct: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2476 >gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sapiens] Length = 3538 Score = 69.3 bits (168), Expect = 7e-12 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 6/127 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRL 272 + + C N+TAP G + SPD+P+ YG + NC W + PG+ + L+F F+L D L Sbjct: 612 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFL 671 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDA 329 ++D S +L F GA P L + L L F++D +GF +TY + Sbjct: 672 AVKDGDSPESPILGTFTGAEVP--SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 729 Query: 330 AEDPEAP 336 DP P Sbjct: 730 CPDPGIP 736 Score = 55.1 bits (131), Expect = 1e-07 Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRDA 277 C G+++AP GVI SP +P Y NC W + PG ++++TF F+ D LE+ D Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDG 850 Query: 278 AS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 + LL +++G + P L + + L F +D GF + Y + Sbjct: 851 PNLLSPLLGSYNGTQVPQF--LFSSSNFIYLLFTTDNSRSNNGFKIHYESV 899 Score = 51.6 bits (122), Expect = 1e-06 Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD 276 +C G G+I SP FP+EY + +C+W + PG + L F F++ + D LE+ Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG 299 Query: 277 AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 + ++ G PP P+ L L F +D+ +GF+ Y+ Sbjct: 300 SEPPTIW--LSGMNIPP--PIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 V + C GN T G I SP+FP Y R+C W + + L F F + D L Sbjct: 1479 VCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFL 1538 Query: 273 ELRDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG-LQDA 329 + D ++ L+ +F ++ P + + + L FRSD GF L Y+ L+++ Sbjct: 1539 YIYDGPDSNSPLIGSFQDSKLPER--IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1596 Query: 330 AEDP 333 DP Sbjct: 1597 CFDP 1600 Score = 50.8 bits (120), Expect = 3e-06 Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 + + C G + GVI SP FP Y +C+W + P G + L F F D L Sbjct: 2002 ICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYL 2061 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DA 329 E+R +S +++ G + P S L T L F SD + QGF + Y+ Q + Sbjct: 2062 EVRSGSSETSTVIGRLSGPQIPSS--LFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2119 Query: 330 AEDP 333 DP Sbjct: 2120 CPDP 2123 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 4/123 (3%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G+ P G I SP +P+ Y NC+W + G ++ F F L D D L + + Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1022 Query: 278 ASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAEDPE 334 S + L R PP G L F SD +GF +T+ + EDP Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1082 Query: 335 APE 337 P+ Sbjct: 1083 IPQ 1085 Score = 48.9 bits (115), Expect = 1e-05 Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 6/122 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G T +G I SP +P+ Y + NC W + P GA +++ F D L+ D Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1894 Query: 278 ASGSL--LRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDAAEDPE 334 + L ++ G P L + L L F+SD A GF L Y + D+ +P+ Sbjct: 1895 GDNNAPRLGSYSGTTIPHL--LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQ 1952 Query: 335 AP 336 P Sbjct: 1953 TP 1954 Score = 47.0 bits (110), Expect = 4e-05 Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 10/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 V C + T +G++ SP++P Y + C +++ G + ++ R F LA D L++ Sbjct: 1134 VAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQ-GDVLKI 1192 Query: 275 RDAASGS--LLRAFDGARPPPSGPLRLGTAA--LLLTFRSDARGHAQGFALTYRGLQ-DA 329 D + LL AF GA L L + + L L F SD G +GF L Y + Sbjct: 1193 YDGKDKTTHLLGAFTGA---SMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1249 Query: 330 AEDPEAPE 337 EDP P+ Sbjct: 1250 CEDPGIPQ 1257 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 6/126 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C GN TA G IYSP +PDEY ++C W + PPG + + F + + D + + D Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2238 Query: 278 --ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEA 335 + + F G S + + +L+ F SD + F L+Y Q P Sbjct: 2239 PDQNSPQIGQFSGNTALES--VYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPPP 2295 Query: 336 PEGSAQ 341 P +A+ Sbjct: 2296 PVPNAE 2301 Score = 41.6 bits (96), Expect = 0.002 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 8/131 (6%) Query: 202 LCGGDGRLGVYEVSVGSCQG----NWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALE 257 + G DGR G + ++ SC T +G + SP++P Y NC +++ P + Sbjct: 1638 IMGDDGRPG-WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1696 Query: 258 LTFRLFELADPRDRLELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGH 315 +F D +E+ D + SLL + G+ S PL G + + F S Sbjct: 1697 FGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGN-QITIRFTSVGPIT 1755 Query: 316 AQGFALTYRGL 326 A+GF Y+ + Sbjct: 1756 AKGFHFVYQAV 1766 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 5/116 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRLELRD 276 +C G G I SP FP Y NC+W + +++ F+ F L + D L L D Sbjct: 64 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYD 123 Query: 277 A--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAA 330 + G PP P+ + L SD A GF + Y LQ ++ Sbjct: 124 GHPHPTNFRTRLTGFHLPP--PVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS 177 Score = 39.7 bits (91), Expect = 0.006 Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 9/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGP--PGAALELTFRLFELADPRDRLE 273 V +C N P G SP+FP +Y + C W + +++ F F+L D L Sbjct: 441 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 500 Query: 274 LRDAAS----GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-D 328 + D ++L+ G+ P + ++ + L ++D + GF + Y+ ++ + Sbjct: 501 IGDGGEVGDPRTVLQVLTGSFVPDL--IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 558 Query: 329 AAEDPEAP 336 + DP P Sbjct: 559 SCGDPGTP 566 Score = 29.3 bits (64), Expect = 7.9 Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 228 GVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRD 276 GVI SP +PD Y + C+W++ G + + F+ D L++ D Sbjct: 2363 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2412 >gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens] Length = 3707 Score = 69.3 bits (168), Expect = 7e-12 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 6/127 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRL 272 + + C N+TAP G + SPD+P+ YG + NC W + PG+ + L+F F+L D L Sbjct: 716 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFL 775 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDA 329 ++D S +L F GA P L + L L F++D +GF +TY + Sbjct: 776 AVKDGDSPESPILGTFTGAEVP--SHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 833 Query: 330 AEDPEAP 336 DP P Sbjct: 834 CPDPGIP 840 Score = 55.1 bits (131), Expect = 1e-07 Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRDA 277 C G+++AP GVI SP +P Y NC W + PG ++++TF F+ D LE+ D Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDG 954 Query: 278 AS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 + LL +++G + P L + + L F +D GF + Y + Sbjct: 955 PNLLSPLLGSYNGTQVPQF--LFSSSNFIYLLFTTDNSRSNNGFKIHYESV 1003 Score = 53.9 bits (128), Expect = 3e-07 Identities = 32/109 (29%), Positives = 53/109 (48%), Gaps = 5/109 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD 276 +C G G+I SP FP+EY + +C+W + PG + L F F++ + D LE+ Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG 299 Query: 277 AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG 325 + ++ G PP P+ L L F +D+ +GF+ Y+G Sbjct: 300 SEPPTIW--LSGMNIPP--PIISNKNWLRLHFVTDSNHRYRGFSAPYQG 344 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 V + C GN T G I SP+FP Y R+C W + + L F F + D L Sbjct: 1583 VCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFL 1642 Query: 273 ELRDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG-LQDA 329 + D ++ L+ +F ++ P + + + L FRSD GF L Y+ L+++ Sbjct: 1643 YIYDGPDSNSPLIGSFQDSKLPER--IESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1700 Query: 330 AEDP 333 DP Sbjct: 1701 CFDP 1704 Score = 50.8 bits (120), Expect = 3e-06 Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 6/124 (4%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRL 272 + + C G + GVI SP FP Y +C+W + P G + L F F D L Sbjct: 2106 ICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYL 2165 Query: 273 ELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DA 329 E+R +S +++ G + P S L T L F SD + QGF + Y+ Q + Sbjct: 2166 EVRSGSSETSTVIGRLSGPQIPSS--LFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS 2223 Query: 330 AEDP 333 DP Sbjct: 2224 CPDP 2227 Score = 50.4 bits (119), Expect = 3e-06 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 4/123 (3%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G+ P G I SP +P+ Y NC+W + G ++ F F L D D L + + Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITEN 1126 Query: 278 ASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAEDPE 334 S + L R PP G L F SD +GF +T+ + EDP Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPG 1186 Query: 335 APE 337 P+ Sbjct: 1187 IPQ 1189 Score = 48.9 bits (115), Expect = 1e-05 Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 6/122 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G T +G I SP +P+ Y + NC W + P GA +++ F D L+ D Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1998 Query: 278 ASGSL--LRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDAAEDPE 334 + L ++ G P L + L L F+SD A GF L Y + D+ +P+ Sbjct: 1999 GDNNAPRLGSYSGTTIPHL--LNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQ 2056 Query: 335 AP 336 P Sbjct: 2057 TP 2058 Score = 47.0 bits (110), Expect = 4e-05 Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 10/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 V C + T +G++ SP++P Y + C +++ G + ++ R F LA D L++ Sbjct: 1238 VAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQ-GDVLKI 1296 Query: 275 RDAASGS--LLRAFDGARPPPSGPLRLGTAA--LLLTFRSDARGHAQGFALTYRGLQ-DA 329 D + LL AF GA L L + + L L F SD G +GF L Y + Sbjct: 1297 YDGKDKTTHLLGAFTGA---SMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1353 Query: 330 AEDPEAPE 337 EDP P+ Sbjct: 1354 CEDPGIPQ 1361 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 6/126 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C GN TA G IYSP +PDEY ++C W + PPG + + F + + D + + D Sbjct: 2283 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDG 2342 Query: 278 --ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEA 335 + + F G S + + +L+ F SD + F L+Y Q P Sbjct: 2343 PDQNSPQIGQFSGNTALES--VYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVCQPPP 2399 Query: 336 PEGSAQ 341 P +A+ Sbjct: 2400 PVPNAE 2405 Score = 41.6 bits (96), Expect = 0.002 Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 8/131 (6%) Query: 202 LCGGDGRLGVYEVSVGSCQG----NWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALE 257 + G DGR G + ++ SC T +G + SP++P Y NC +++ P + Sbjct: 1742 IMGDDGRPG-WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVV 1800 Query: 258 LTFRLFELADPRDRLELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGH 315 +F D +E+ D + SLL + G+ S PL G + + F S Sbjct: 1801 FGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGN-QITIRFTSVGPIT 1859 Query: 316 AQGFALTYRGL 326 A+GF Y+ + Sbjct: 1860 AKGFHFVYQAV 1870 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/116 (27%), Positives = 46/116 (39%), Gaps = 5/116 (4%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRLELRD 276 +C G G I SP FP Y NC+W + +++ F+ F L + D L L D Sbjct: 64 TCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYD 123 Query: 277 A--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAA 330 + G PP P+ + L SD A GF + Y LQ ++ Sbjct: 124 GHPHPTNFRTRLTGFHLPP--PVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS 177 Score = 39.7 bits (91), Expect = 0.006 Identities = 29/128 (22%), Positives = 56/128 (43%), Gaps = 9/128 (7%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGP--PGAALELTFRLFELADPRDRLE 273 V +C N P G SP+FP +Y + C W + +++ F F+L D L Sbjct: 545 VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLT 604 Query: 274 LRDAAS----GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-D 328 + D ++L+ G+ P + ++ + L ++D + GF + Y+ ++ + Sbjct: 605 IGDGGEVGDPRTVLQVLTGSFVPDL--IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 662 Query: 329 AAEDPEAP 336 + DP P Sbjct: 663 SCGDPGTP 670 Score = 29.3 bits (64), Expect = 7.9 Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 228 GVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRD 276 GVI SP +PD Y + C+W++ G + + F+ D L++ D Sbjct: 2467 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYD 2516 >gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] Length = 3487 Score = 65.5 bits (158), Expect = 1e-10 Identities = 44/148 (29%), Positives = 67/148 (45%), Gaps = 14/148 (9%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 + C G+ T P GVI SP++P+ Y P + C W + P + L F +F L D L + Sbjct: 1442 IAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHI 1501 Query: 275 RDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAED 332 D + L+ +F G++ P G + + +L L FRSDA GF + Y Sbjct: 1502 YDGRDSLSPLIGSFYGSQLP--GRIESSSNSLFLAFRSDASVSNAGFVIDY--------- 1550 Query: 333 PEAPEGSAQTPAAPLDGANVSCSPRPGA 360 E P S P + +G V + G+ Sbjct: 1551 TENPRESCFDPGSIKNGTRVGSDLKLGS 1578 Score = 59.3 bits (142), Expect = 7e-09 Identities = 63/204 (30%), Positives = 83/204 (40%), Gaps = 32/204 (15%) Query: 207 GRLGVYEVS----VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFR 261 G L + VS V C GN T +G I SP FP+ Y NC W + P GA +++ Sbjct: 1780 GALAQWNVSAPTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVV 1839 Query: 262 LFELADPRDRLELRDAASG--SLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGF 319 F D LE+ D A ++L +F G P L + L L F SD A GF Sbjct: 1840 SFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVP--ALLNSTSNQLYLHFYSDISVSAAGF 1897 Query: 320 ALTYR--GLQDAAEDPEAPEGSAQT---------------PAAPLDG-ANVSCSP----R 357 L Y+ GL E P P +T P L G A++SC P R Sbjct: 1898 HLEYKTVGLSSCPE-PAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRR 1956 Query: 358 PGAPPAAIGARVFSTVTAVSVLLL 381 PP A+ TV + ++L Sbjct: 1957 WNYPPPLCIAQCGGTVEEMEGVIL 1980 Score = 55.5 bits (132), Expect = 1e-07 Identities = 37/125 (29%), Positives = 62/125 (49%), Gaps = 6/125 (4%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELADPRDRLEL 274 V SC N+T+P GV+ SP++P++YG +C W L P + + L F ++ D L + Sbjct: 575 VFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQFDFLVI 634 Query: 275 RDAASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAE 331 +D A+ +L F G + P S + L F++D +GF +T+ + + Sbjct: 635 KDGATAEAPVLGTFSGNQLPSS--ITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECP 692 Query: 332 DPEAP 336 DP P Sbjct: 693 DPGVP 697 Score = 54.3 bits (129), Expect = 2e-07 Identities = 47/155 (30%), Positives = 63/155 (40%), Gaps = 17/155 (10%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRLELRD 276 +C G G+I SP FP EY + +C+W L G + L F F+L D D LE+ Sbjct: 201 ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGYDFLEVTG 260 Query: 277 AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTY----------RGL 326 SL F GA P P+ L L F SD +GF+ Y RG+ Sbjct: 261 TEGSSLW--FTGASLP--APVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKSRGV 316 Query: 327 QDAAEDPEAPEGSAQTPAAPLDGANVSCSPRPGAP 361 + + + S T G N+ P PG P Sbjct: 317 KLMPSKDNSQKTSVLTQVGVSQGHNM--CPDPGIP 349 Score = 52.4 bits (124), Expect = 9e-07 Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 10/125 (8%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRDA 277 C G+ T+P G I SP +P Y +C+W + PG +++TF F+ D LE+RD Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDTLEVRDG 811 Query: 278 A--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQ-GFALTYRGL---QDAAE 331 S L+ + G + P + T+ L S + H+ GF L Y + D Sbjct: 812 RTYSAPLIGVYHGTQVP---QFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCL 868 Query: 332 DPEAP 336 DP P Sbjct: 869 DPGIP 873 Score = 52.0 bits (123), Expect = 1e-06 Identities = 45/149 (30%), Positives = 71/149 (47%), Gaps = 7/149 (4%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLEL 274 V C + T QG + SP+FP Y + C +++ PG ++L R FEL++ D L++ Sbjct: 1095 VAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSE-GDVLKV 1153 Query: 275 RDAASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAE 331 D + S LL F + L +++L L F +DA ++GF L + + E Sbjct: 1154 YDGNNNSARLLGVFSHSE-MMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCE 1212 Query: 332 DPEAPE-GSAQTPAAPLDGANVSCSPRPG 359 DP P+ G G++VS S PG Sbjct: 1213 DPGTPKFGYKVHDEGHFAGSSVSFSCDPG 1241 Score = 49.3 bits (116), Expect = 7e-06 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 4/122 (3%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPP-GAALELTFRLFELADPRDRLELRDA 277 C G G I SP FPD Y + NC+W + G + TF F L D L + + Sbjct: 924 CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITEN 983 Query: 278 ASGSL-LRAFDGAR-PPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAEDPE 334 S + LR G+R P P G + F SD +GF +T+ + E+PE Sbjct: 984 GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPE 1043 Query: 335 AP 336 P Sbjct: 1044 VP 1045 Score = 49.3 bits (116), Expect = 7e-06 Identities = 33/114 (28%), Positives = 50/114 (43%), Gaps = 5/114 (4%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 + C G +GVI SP FP Y + +CSW + P G + F F D +E+ Sbjct: 1965 IAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEI 2024 Query: 275 RDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 R+ + ++ F G+ P S L + + F SD + GF L Y+ L Sbjct: 2025 RNGPYETSRMMGRFSGSELPSS--LLSTSHETTVYFHSDHSQNRPGFKLEYQDL 2076 Score = 47.0 bits (110), Expect = 4e-05 Identities = 35/126 (27%), Positives = 57/126 (45%), Gaps = 11/126 (8%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGP--PGAALELTFRLFELADPRDRLEL-- 274 C + P G+I SP+FP +Y + +C W + P ++L F F+L D L + Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGD 464 Query: 275 --RDAASGSLLRAFDGARPPPSGPLRLGT-AALLLTFRSDARGHAQGFALTYRGL-QDAA 330 +D ++L G P L + T + L F++D G + GF +Y + Q + Sbjct: 465 GGQDGDQKTVLYILTGTSVP---DLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSC 521 Query: 331 EDPEAP 336 DP P Sbjct: 522 GDPGIP 527 Score = 43.9 bits (102), Expect = 3e-04 Identities = 32/119 (26%), Positives = 53/119 (44%), Gaps = 6/119 (5%) Query: 228 GVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD--AASGSLLR 284 G + SP +P Y + NC W + G + L F +F+ + D L + D SG LL+ Sbjct: 1281 GQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLK 1340 Query: 285 AFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR-GLQDAAEDPEAPEGSAQT 342 G P L +++L F +D QGFA+ + + DP P+ +++ Sbjct: 1341 ELSGPALPKD--LHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRS 1397 Score = 43.9 bits (102), Expect = 3e-04 Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 1/95 (1%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPP-GAALELTFRLFELADPRDRLELRDA 277 C GN T+ G +YSP FP Y ++C W + P G + L L + D + + D Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDG 2241 Query: 278 ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDA 312 + R R ++ + +LL F DA Sbjct: 2242 PQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDA 2276 Score = 38.9 bits (89), Expect = 0.010 Identities = 35/121 (28%), Positives = 48/121 (39%), Gaps = 23/121 (19%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD 276 +C P G + SP FP Y NC+W + ++L F+ F L + D Sbjct: 25 NCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFD------ 78 Query: 277 AASGSLLRAFDGARPPPS---------GPLRLGTAALLLTFR--SDARGHAQGFALTYRG 325 +L FDG P + P + +AA L+ R SD AQGF TY Sbjct: 79 -----VLSVFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEV 133 Query: 326 L 326 L Sbjct: 134 L 134 Score = 38.1 bits (87), Expect = 0.017 Identities = 40/131 (30%), Positives = 55/131 (41%), Gaps = 20/131 (15%) Query: 224 TAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDAASGS- 281 T GVI S +P Y + CSW + P + LT F D E+ D SG Sbjct: 2362 TDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQS 2421 Query: 282 -LLRAFDGARPPPSGPLRLGTA--ALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEG 338 LL+A G S PL + ++ ++ L + SD + +GF + Y AP Sbjct: 2422 PLLKALSGNY---SAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRY----------SAPYC 2468 Query: 339 SAQTPAAPLDG 349 S P APL G Sbjct: 2469 S--LPRAPLHG 2477 Score = 36.6 bits (83), Expect = 0.049 Identities = 28/115 (24%), Positives = 46/115 (40%), Gaps = 3/115 (2%) Query: 214 VSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADPRDRLE 273 V C G + GV+ SP++P Y + C + + P + F D +E Sbjct: 1614 VCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVE 1673 Query: 274 LRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 + D S LL + G+ S PL +L+ F + A+GF Y+ + Sbjct: 1674 VHDGHSQHSRLLSSLSGSHTGESLPLATSN-QVLIKFSAKGLAPARGFHFVYQAV 1727 >gi|4504383 HGF activator preproprotein [Homo sapiens] Length = 655 Score = 65.5 bits (158), Expect = 1e-10 Identities = 32/86 (37%), Positives = 44/86 (51%), Gaps = 6/86 (6%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFW--DQTQQHSYSSASDPHGRWGLGAHNFCRNPD 93 CF NG YRG + + +G CL W D Q + + GLG H +CRNPD Sbjct: 286 CFLGNGTGYRGVASTSA---SGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPD 342 Query: 94 GDVQPWCYVAETEEGIYWRYCDIPSC 119 D +PWCYV + + + W YC + +C Sbjct: 343 NDERPWCYVVK-DSALSWEYCRLEAC 367 >gi|4505881 plasminogen [Homo sapiens] Length = 810 Score = 65.1 bits (157), Expect = 1e-10 Identities = 39/109 (35%), Positives = 53/109 (48%), Gaps = 13/109 (11%) Query: 28 LHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSAS-DPHGRWGLGAH 86 + +P +C NG YRG + T G PC W + H +S + + + R GL Sbjct: 473 VETPSEEDCMFGNGKGYRGKRATTV---TGTPCQDWAAQEPHRHSIFTPETNPRAGL-EK 528 Query: 87 NFCRNPDGDV-QPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAP 134 N+CRNPDGDV PWCY + + YCD+P C P + D G P Sbjct: 529 NYCRNPDGDVGGPWCYTTNPRK--LYDYCDVPQCAAPSF-----DCGKP 570 Score = 64.3 bits (155), Expect = 2e-10 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 6/90 (6%) Query: 30 SPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFC 89 +P + +C+ +G YRG + T G+ C W H + + + GL N+C Sbjct: 371 TPVVQDCYHGDGQSYRGTSSTTT---TGKKCQSWSSMTPHRHQKTPENYPNAGL-TMNYC 426 Query: 90 RNPDGDVQPWCYVAETEEGIYWRYCDIPSC 119 RNPD D PWC+ T+ + W YC++ C Sbjct: 427 RNPDADKGPWCFT--TDPSVRWEYCNLKKC 454 Score = 61.6 bits (148), Expect = 1e-09 Identities = 36/88 (40%), Positives = 44/88 (50%), Gaps = 7/88 (7%) Query: 33 LSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNP 92 LSEC NG +YRG ++T G C W T H + H GL N+CRNP Sbjct: 100 LSECKTGNGKNYRGTMSKT---KNGITCQKWSSTSPHRPRFSPATHPSEGL-EENYCRNP 155 Query: 93 DGDVQ-PWCYVAETEEGIYWRYCDIPSC 119 D D Q PWCY + E+ + YCDI C Sbjct: 156 DNDPQGPWCYTTDPEK--RYDYCDILEC 181 Score = 59.3 bits (142), Expect = 7e-09 Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 6/88 (6%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 EC +G +Y G ++T +G C WD H++ L N+CRNPD Sbjct: 184 ECMHCSGENYDGKISKTM---SGLECQAWDSQSPHAHGYIPSKFPNKNL-KKNYCRNPDR 239 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSCHMP 122 +++PWC+ T+ W CDIP C P Sbjct: 240 ELRPWCFT--TDPNKRWELCDIPRCTTP 265 Score = 58.5 bits (140), Expect = 1e-08 Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 6/104 (5%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 +C + G +YRG+ T +G C W H+++ + L N+CRNPDG Sbjct: 274 QCLKGTGENYRGNVAVTV---SGHTCQHWSAQTPHTHNRTPENFPCKNLD-ENYCRNPDG 329 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALS 138 PWC+ T + W YC IPSC + APP L+ Sbjct: 330 KRAPWCHT--TNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELT 371 >gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-like) [Homo sapiens] Length = 725 Score = 65.1 bits (157), Expect = 1e-10 Identities = 47/145 (32%), Positives = 60/145 (41%), Gaps = 19/145 (13%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGD 95 C NG +YRG +RT +GR C WD H + GL N+CRNPDG Sbjct: 205 CVWCNGEEYRGAVDRTE---SGRECQRWDLQHPHQHPFEPGKFLDQGLD-DNYCRNPDGS 260 Query: 96 VQPWCYVAETEEGIYWRYCDIPSCHMPGY-------LGCFVDSGAPPALSGPSGTSTKLT 148 +PWCY T+ I +CD+P C + CF G G GT+ T Sbjct: 261 ERPWCYT--TDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKG-----EGYRGTANTTT 313 Query: 149 VQV-CLRFCRMKGYQLAGVEAGYAC 172 V C R+ +Q YAC Sbjct: 314 AGVPCQRWDAQIPHQHRFTPEKYAC 338 Score = 53.5 bits (127), Expect = 4e-07 Identities = 36/95 (37%), Positives = 42/95 (44%), Gaps = 13/95 (13%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQT--QQHSYSSASDPHGRWGLGAHNFCRNPD 93 C NG YRG T G PC W H Y+ P R GL NFCRNPD Sbjct: 124 CIMNNGVGYRGTMATTV---GGLPCQAWSHKFPNDHKYT----PTLRNGL-EENFCRNPD 175 Query: 94 GDV-QPWCYVAETEEGIYWRYCDIPSCHMPGYLGC 127 GD PWCY T+ + ++ C I SC + C Sbjct: 176 GDPGGPWCYT--TDPAVRFQSCGIKSCREAACVWC 208 Score = 53.1 bits (126), Expect = 5e-07 Identities = 27/66 (40%), Positives = 32/66 (48%), Gaps = 4/66 (6%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGD 95 CF+ G YRG N T AG PC WD H + + + L NFCRNPDG Sbjct: 297 CFRGKGEGYRGTANTTT---AGVPCQRWDAQIPHQHRFTPEKYACKDL-RENFCRNPDGS 352 Query: 96 VQPWCY 101 PWC+ Sbjct: 353 EAPWCF 358 Score = 49.3 bits (116), Expect = 7e-06 Identities = 29/88 (32%), Positives = 40/88 (45%), Gaps = 11/88 (12%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHS--YSSASDPHGRWGLGAHNFCRNP 92 +C+ G YRG ++T G C W H ++ S+PH + NFCRNP Sbjct: 383 DCYHGAGEQYRGTVSKTRK---GVQCQRWSAETPHKPQFTFTSEPHAQL---EENFCRNP 436 Query: 93 DGDVQ-PWCYVAETEEGIYWRYCDIPSC 119 DGD PWCY + + YC + C Sbjct: 437 DGDSHGPWCYTMDPRTP--FDYCALRRC 462 >gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] Length = 3565 Score = 64.3 bits (155), Expect = 2e-10 Identities = 46/142 (32%), Positives = 70/142 (49%), Gaps = 6/142 (4%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELADPRDRLEL 274 V SC N+TA G+I SP++P+EYG + NC W + PG+ + L F F++ D L + Sbjct: 582 VFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAV 641 Query: 275 RD--AASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL-QDAAE 331 +D + ++L F G P L + L F+SD +GF +TY Q+ Sbjct: 642 KDDGISDITVLGTFSGNEVP--SQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECH 699 Query: 332 DPEAPEGSAQTPAAPLDGANVS 353 DP P + L G++VS Sbjct: 700 DPGIPINGRRFGDRFLLGSSVS 721 Score = 62.8 bits (151), Expect = 6e-10 Identities = 40/148 (27%), Positives = 68/148 (45%), Gaps = 14/148 (9%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 + +C GN T P GVI SP++P Y P + C W + P + L F+ F + D L + Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHI 1508 Query: 275 RDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAED 332 + ++ L+ ++ G++ P + +L L FRSDA GFA+ ++ Sbjct: 1509 YEGEDSNSPLIGSYQGSQAPER--IESSGNSLFLAFRSDASVGLSGFAIEFK-------- 1558 Query: 333 PEAPEGSAQTPAAPLDGANVSCSPRPGA 360 E P + P ++G V + G+ Sbjct: 1559 -EKPREACFDPGNIMNGTRVGTDFKLGS 1585 Score = 56.2 bits (134), Expect = 6e-08 Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 6/125 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELADPRDRLELRDA 277 C GN+T +G I SP +P+ YG + NC W + G+ +++ F D LE+ D Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDG 1862 Query: 278 --ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAA-EDPE 334 + L +F G P L + L L F+SD A GF L Y+ + AA ++P Sbjct: 1863 GDVTAPRLGSFSGTTVP--ALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPA 1920 Query: 335 APEGS 339 P S Sbjct: 1921 LPSNS 1925 Score = 53.5 bits (127), Expect = 4e-07 Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 10/125 (8%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRD- 276 C G+ TA GVI P +P Y +C W + PG ++++TF F+ D LE+RD Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDG 818 Query: 277 -AASGSLLRAFDGARPPPSGPLRLGTAALL-LTFRSDARGHAQGFALTYRGL---QDAAE 331 A+S L+ + G + P + T + L F +D + GF + Y + D+ Sbjct: 819 PASSSPLIGEYHGTQAP---QFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCL 875 Query: 332 DPEAP 336 DP P Sbjct: 876 DPGIP 880 Score = 50.1 bits (118), Expect = 4e-06 Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 7/128 (5%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLEL 274 + +C G + GVI SP FP Y + +C+W + P G + F F D LE+ Sbjct: 1972 IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEI 2031 Query: 275 RDAA--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG--LQDAA 330 ++ + ++ F G P + L T L+ F SD + QGF L Y+ LQ+ Sbjct: 2032 QNGPYHTSPMIGQFSGTDLPAA--LLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCP 2089 Query: 331 EDPEAPEG 338 + P G Sbjct: 2090 DPPPFQNG 2097 Score = 46.6 bits (109), Expect = 5e-05 Identities = 33/104 (31%), Positives = 46/104 (44%), Gaps = 5/104 (4%) Query: 217 GSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWA-LGPPGAALELTFRLFELADPRDRLELR 275 G+C G I SP FP EY + +C+W L PG + L F F+L + D LE+ Sbjct: 206 GACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEIS 265 Query: 276 DAASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGF 319 + S+ G P P+ L L F SD+ +GF Sbjct: 266 GTEAPSIW--LTGMNLP--SPVISSKNWLRLHFTSDSNHRRKGF 305 Score = 46.6 bits (109), Expect = 5e-05 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 9/139 (6%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL--GPPGAALELTFRLFELADPRDRLELR 275 +C N P GVI SP++P +Y + +C W + P ++L F FEL D L + Sbjct: 411 TCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVG 470 Query: 276 DAA----SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAA 330 DA + S+L G+ P + + + L +SD + GF Y+ ++ Sbjct: 471 DAGKVGDTRSVLYVLTGSSVPDL--IVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGC 528 Query: 331 EDPEAPEGSAQTPAAPLDG 349 DP P +T ++ L G Sbjct: 529 GDPGIPAYGKRTGSSFLHG 547 Score = 43.9 bits (102), Expect = 3e-04 Identities = 22/59 (37%), Positives = 31/59 (52%), Gaps = 1/59 (1%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRD 276 C N T+ G IYSP FPDEY ++C W + PPG + + F L + D + + D Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAVWD 2205 Score = 42.7 bits (99), Expect = 7e-04 Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 7/113 (6%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELADPRDRLELRD 276 +C G P G I SP FP Y NC+W + ++L+F F L + D L + D Sbjct: 31 NCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYD 90 Query: 277 A--ASGSLLRAFDGARPPPSGPLRLGTAALL-LTFRSDARGHAQGFALTYRGL 326 G+L G + P S + T ++L L F +D AQGF Y L Sbjct: 91 GQPQQGNLKVRLSGFQLPSS---IVSTGSILTLWFTTDFAVSAQGFKALYEVL 140 Score = 42.7 bits (99), Expect = 7e-04 Identities = 33/122 (27%), Positives = 47/122 (38%), Gaps = 4/122 (3%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPRDRLELRDA 277 C G G + SP FPD Y NC+W + G +++ F F L D L + + Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITED 990 Query: 278 ASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQ-DAAEDPE 334 S S + R P G L F SD +GF +T+ + +DP Sbjct: 991 GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPG 1050 Query: 335 AP 336 P Sbjct: 1051 VP 1052 Score = 42.4 bits (98), Expect = 9e-04 Identities = 38/149 (25%), Positives = 62/149 (41%), Gaps = 7/149 (4%) Query: 216 VGSCQGN-WTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLE 273 + C G A G I SP +P Y + +C+W + PG + L F +F+ D L+ Sbjct: 1275 IAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILK 1334 Query: 274 LRDAA--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTY-RGLQDAA 330 + D S LL+ + G+ P + +L L F SD GF++ + + Sbjct: 1335 VWDGPVDSDILLKEWSGSALPED--IHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATC 1392 Query: 331 EDPEAPEGSAQTPAAPLDGANVSCSPRPG 359 DP P+ + + G V+ PG Sbjct: 1393 NDPGMPQNGTRYGDSREAGDTVTFQCDPG 1421 Score = 41.6 bits (96), Expect = 0.002 Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 5/111 (4%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALEL-TFRLFELADPRDRLELRDA 277 C G +T +GV+ SP++P Y + C +++ P + F F+ A D EL D Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTA-LNDLAELFDG 1684 Query: 278 --ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGL 326 A LL + G+ + PL +LL F + + A+GF Y+ + Sbjct: 1685 THAQARLLSSLSGSHSGETLPLATSN-QILLRFSAKSGASARGFHFVYQAV 1734 Score = 37.4 bits (85), Expect = 0.029 Identities = 32/121 (26%), Positives = 50/121 (41%), Gaps = 10/121 (8%) Query: 212 YEVSVGSCQGNW------TAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFE 264 +E S+ +C+ T GVI SP +P Y + CSW++ P + + F+ Sbjct: 2309 FEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQ 2368 Query: 265 LADPRDRLELRDAASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALT 322 D LE+ D +SG LL G S + L L + +D +GF + Sbjct: 2369 SEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSN-FTSRSNQLYLRWSTDHATSKKGFKIR 2427 Query: 323 Y 323 Y Sbjct: 2428 Y 2428 Score = 36.2 bits (82), Expect = 0.064 Identities = 33/124 (26%), Positives = 50/124 (40%), Gaps = 4/124 (3%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLEL 274 V C + +G + SP+FP Y + C + + G + L R F+L + D L++ Sbjct: 1102 VAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFE-GDTLKV 1160 Query: 275 RDAASGSLLRAFDGARPPPSGPLRLGTA-ALLLTFRSDARGHAQGFALTYRGLQ-DAAED 332 D S + G + T+ L L F ++ QGF LTY ED Sbjct: 1161 YDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCED 1220 Query: 333 PEAP 336 P P Sbjct: 1221 PGIP 1224 >gi|54792094 WSC domain containing 1 [Homo sapiens] Length = 575 Score = 62.4 bits (150), Expect = 8e-10 Identities = 37/100 (37%), Positives = 47/100 (47%), Gaps = 5/100 (5%) Query: 117 PSCHMPG-YLGCFVDSGAPPALSGPSGTST-KLTVQVCLRFCRMKGYQLAGVEAGYACFC 174 P+ H G Y+GCF D G L G K+TV C C + Y AG+EAG C+C Sbjct: 137 PAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYC 196 Query: 175 GSESDLARGRLAPATDCDQICFGHPGQLCGGDGRLGVYEV 214 G+ L +C+ C G G +CG RL VY V Sbjct: 197 GNRLPAVSVGL---EECNHECKGEKGSVCGAVDRLSVYRV 233 >gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo sapiens] Length = 285 Score = 61.2 bits (147), Expect = 2e-09 Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 EC NG YRG + T +G+ C WD H + + + G N+CRNPDG Sbjct: 205 ECMTCNGESYRGLMDHTE---SGKICQRWDHQTPHRHKFLPERYPDKGFD-DNYCRNPDG 260 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSC 119 +PWCY + W YC I +C Sbjct: 261 QPRPWCYTLDPH--TRWEYCAIKTC 283 Score = 40.0 bits (92), Expect = 0.004 Identities = 25/88 (28%), Positives = 36/88 (40%), Gaps = 12/88 (13%) Query: 33 LSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNP 92 + C G Y+G + T +G C W H +S N+CRNP Sbjct: 125 IRNCIIGKGRSYKGTVSITK---SGIKCQPWSSMIPHEHSYRGKDL------QENYCRNP 175 Query: 93 DGDV-QPWCYVAETEEGIYWRYCDIPSC 119 G+ PWC+ + E + + CDIP C Sbjct: 176 RGEEGGPWCFTSNPE--VRYEVCDIPQC 201 >gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo sapiens] Length = 723 Score = 61.2 bits (147), Expect = 2e-09 Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 EC NG YRG + T +G+ C WD H + + + G N+CRNPDG Sbjct: 205 ECMTCNGESYRGLMDHTE---SGKICQRWDHQTPHRHKFLPERYPDKGFD-DNYCRNPDG 260 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSC 119 +PWCY + W YC I +C Sbjct: 261 QPRPWCYTLDPH--TRWEYCAIKTC 283 Score = 58.2 bits (139), Expect = 2e-08 Identities = 35/100 (35%), Positives = 44/100 (44%), Gaps = 7/100 (7%) Query: 34 SECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPD 93 +EC Q G YRG N G PC WD H + + L N+CRNPD Sbjct: 298 TECIQGQGEGYRGTVNTIWN---GIPCQRWDSQYPHEHDMTPENFKCKDL-RENYCRNPD 353 Query: 94 GDVQPWCYVAETEEGIYWRYC-DIPSCHMPGYLGCFVDSG 132 G PWC+ T+ I YC IP+C M C+ +G Sbjct: 354 GSESPWCFT--TDPNIRVGYCSQIPNCDMSHGQDCYRGNG 391 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 15/90 (16%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGA----HNFCR 90 +C++ NG +Y G+ ++T +G C WD+ + + H W A N+CR Sbjct: 385 DCYRGNGKNYMGNLSQTR---SGLTCSMWDKNMEDLHR-----HIFWEPDASKLNENYCR 436 Query: 91 NPDGDVQ-PWCYVAETEEGIYWRYCDIPSC 119 NPD D PWCY I W YC I C Sbjct: 437 NPDDDAHGPWCYTGNPL--IPWDYCPISRC 464 Score = 40.0 bits (92), Expect = 0.004 Identities = 25/88 (28%), Positives = 36/88 (40%), Gaps = 12/88 (13%) Query: 33 LSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNP 92 + C G Y+G + T +G C W H +S N+CRNP Sbjct: 125 IRNCIIGKGRSYKGTVSITK---SGIKCQPWSSMIPHEHSYRGKDL------QENYCRNP 175 Query: 93 DGDV-QPWCYVAETEEGIYWRYCDIPSC 119 G+ PWC+ + E + + CDIP C Sbjct: 176 RGEEGGPWCFTSNPE--VRYEVCDIPQC 201 >gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo sapiens] Length = 290 Score = 61.2 bits (147), Expect = 2e-09 Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 EC NG YRG + T +G+ C WD H + + + G N+CRNPDG Sbjct: 210 ECMTCNGESYRGLMDHTE---SGKICQRWDHQTPHRHKFLPERYPDKGFD-DNYCRNPDG 265 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSC 119 +PWCY + W YC I +C Sbjct: 266 QPRPWCYTLDPH--TRWEYCAIKTC 288 Score = 42.4 bits (98), Expect = 9e-04 Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 7/88 (7%) Query: 33 LSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNP 92 + C G Y+G + T +G C W H +S + L N+CRNP Sbjct: 125 IRNCIIGKGRSYKGTVSITK---SGIKCQPWSSMIPHEHSFLPSSYRGKDL-QENYCRNP 180 Query: 93 DGDV-QPWCYVAETEEGIYWRYCDIPSC 119 G+ PWC+ + E + + CDIP C Sbjct: 181 RGEEGGPWCFTSNPE--VRYEVCDIPQC 206 >gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Homo sapiens] Length = 728 Score = 61.2 bits (147), Expect = 2e-09 Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 EC NG YRG + T +G+ C WD H + + + G N+CRNPDG Sbjct: 210 ECMTCNGESYRGLMDHTE---SGKICQRWDHQTPHRHKFLPERYPDKGFD-DNYCRNPDG 265 Query: 95 DVQPWCYVAETEEGIYWRYCDIPSC 119 +PWCY + W YC I +C Sbjct: 266 QPRPWCYTLDPH--TRWEYCAIKTC 288 Score = 58.2 bits (139), Expect = 2e-08 Identities = 35/100 (35%), Positives = 44/100 (44%), Gaps = 7/100 (7%) Query: 34 SECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPD 93 +EC Q G YRG N G PC WD H + + L N+CRNPD Sbjct: 303 TECIQGQGEGYRGTVNTIWN---GIPCQRWDSQYPHEHDMTPENFKCKDL-RENYCRNPD 358 Query: 94 GDVQPWCYVAETEEGIYWRYC-DIPSCHMPGYLGCFVDSG 132 G PWC+ T+ I YC IP+C M C+ +G Sbjct: 359 GSESPWCFT--TDPNIRVGYCSQIPNCDMSHGQDCYRGNG 396 Score = 51.6 bits (122), Expect = 1e-06 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 15/90 (16%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGA----HNFCR 90 +C++ NG +Y G+ ++T +G C WD+ + + H W A N+CR Sbjct: 390 DCYRGNGKNYMGNLSQTR---SGLTCSMWDKNMEDLHR-----HIFWEPDASKLNENYCR 441 Query: 91 NPDGDVQ-PWCYVAETEEGIYWRYCDIPSC 119 NPD D PWCY I W YC I C Sbjct: 442 NPDDDAHGPWCYTGNPL--IPWDYCPISRC 469 Score = 42.4 bits (98), Expect = 9e-04 Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 7/88 (7%) Query: 33 LSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNP 92 + C G Y+G + T +G C W H +S + L N+CRNP Sbjct: 125 IRNCIIGKGRSYKGTVSITK---SGIKCQPWSSMIPHEHSFLPSSYRGKDL-QENYCRNP 180 Query: 93 DGDV-QPWCYVAETEEGIYWRYCDIPSC 119 G+ PWC+ + E + + CDIP C Sbjct: 181 RGEEGGPWCFTSNPE--VRYEVCDIPQC 206 >gi|55749667 WSC domain containing 2 [Homo sapiens] Length = 565 Score = 61.2 bits (147), Expect = 2e-09 Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 4/94 (4%) Query: 124 YLGCFVDSGAPPALSGPSGTS-TKLTVQVCLRFCRMKGYQLAGVEAGYACFCGSESDLAR 182 Y+GC++D AL G S K+T+ C C +GY G+E G C+CG + Sbjct: 130 YIGCYLDDTQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYGGLEFGAECYCGHKIQATN 189 Query: 183 GRLAPATDCDQICFGHPGQLCGGDGRLGVYEVSV 216 +CD C G G +CGG RL VY + + Sbjct: 190 ---VSEAECDMECKGERGSVCGGANRLSVYRLQL 220 >gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sapiens] Length = 414 Score = 60.1 bits (144), Expect = 4e-09 Identities = 29/69 (42%), Positives = 38/69 (55%), Gaps = 5/69 (7%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQ--QHSYSSASDPHGRWGLGAHNFCRNPD 93 C++ NG YRG + GRPCL W+ Q +Y + + GLG HN+CRNPD Sbjct: 53 CYEGNGHFYRG---KASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPD 109 Query: 94 GDVQPWCYV 102 +PWCYV Sbjct: 110 NRRRPWCYV 118 >gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein [Homo sapiens] Length = 431 Score = 60.1 bits (144), Expect = 4e-09 Identities = 29/69 (42%), Positives = 38/69 (55%), Gaps = 5/69 (7%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQ--QHSYSSASDPHGRWGLGAHNFCRNPD 93 C++ NG YRG + GRPCL W+ Q +Y + + GLG HN+CRNPD Sbjct: 70 CYEGNGHFYRG---KASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPD 126 Query: 94 GDVQPWCYV 102 +PWCYV Sbjct: 127 NRRRPWCYV 135 >gi|4503635 coagulation factor II preproprotein [Homo sapiens] Length = 622 Score = 59.7 bits (143), Expect = 5e-09 Identities = 43/130 (33%), Positives = 57/130 (43%), Gaps = 9/130 (6%) Query: 18 LQPRGASAGSLHSPGLSECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDP 77 + PR + SP L +C G Y+G R G PCL W Q + S D Sbjct: 195 MTPRSEGSSVNLSPPLEQCVPDRGQQYQG---RLAVTTHGLPCLAWASAQAKALSKHQDF 251 Query: 78 HGRWGLGAHNFCRNPDGDVQ-PWCYVAETEEGIYWRYCDIPSCH--MPGYLGCFVDSGAP 134 + L NFCRNPDGD + WCYVA + YCD+ C + G +D + Sbjct: 252 NSAVQL-VENFCRNPDGDEEGVWCYVAGKPGD--FGYCDLNYCEEAVEEETGDGLDEDSD 308 Query: 135 PALSGPSGTS 144 A+ G + TS Sbjct: 309 RAIEGRTATS 318 Score = 49.7 bits (117), Expect = 6e-06 Identities = 31/85 (36%), Positives = 37/85 (43%), Gaps = 7/85 (8%) Query: 36 CFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGD 95 C + G +YRGH N T +G C W H S H L NFCRNPD Sbjct: 108 CAEGLGTNYRGHVNITR---SGIECQLWRSRYPHKPEINSTTHPGADL-QENFCRNPDSS 163 Query: 96 VQ-PWCYVAETEEGIYWRYCDIPSC 119 PWCY T+ + + C IP C Sbjct: 164 TTGPWCYT--TDPTVRRQECSIPVC 186 >gi|19743898 receptor tyrosine kinase-like orphan receptor 2 precursor [Homo sapiens] Length = 943 Score = 57.0 bits (136), Expect = 4e-08 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 7/86 (8%) Query: 35 ECFQVNGADYRGHQNRTGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDG 94 +C+ +G DYRG + T +G C W HS+ +S G G H +CRNP G Sbjct: 315 QCYNGSGMDYRGTASTTK---SGHQCQPWALQHPHSHHLSSTDFPELG-GGHAYCRNPGG 370 Query: 95 DVQ-PWCYVAETEEGIYWRYCDIPSC 119 ++ PWC+ + + CD+PSC Sbjct: 371 QMEGPWCFT--QNKNVRMELCDVPSC 394 >gi|126091152 cubilin [Homo sapiens] Length = 3623 Score = 57.0 bits (136), Expect = 4e-08 Identities = 39/115 (33%), Positives = 59/115 (51%), Gaps = 7/115 (6%) Query: 215 SVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELAD----PR 269 SV +C G + +G+ SP +PD Y P+ C W + PG L+L+F F+L D R Sbjct: 1734 SVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSR 1793 Query: 270 DRLELRDA-ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTY 323 D +E+R+ A+G L+ + G P + +G L + F SD G GF T+ Sbjct: 1794 DFVEIREGNATGHLVGRYCGNSFPLNYSSIVG-HTLWVRFISDGSGSGTGFQATF 1847 Score = 48.1 bits (113), Expect = 2e-05 Identities = 41/129 (31%), Positives = 53/129 (41%), Gaps = 9/129 (6%) Query: 202 LCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTF 260 L G G +E C G T P G I SP +P Y P R+C W + P + TF Sbjct: 573 LRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTF 632 Query: 261 RLFELAD----PRDRLELRDAA--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARG 314 L +D LE+RD LL F P PL+ + F SD++ Sbjct: 633 GTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVP--PLQTTGPFARIHFHSDSQI 690 Query: 315 HAQGFALTY 323 QGF +TY Sbjct: 691 SDQGFHITY 699 Score = 46.2 bits (108), Expect = 6e-05 Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 2/122 (1%) Query: 205 GDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLF 263 G G ++ G C G + AP G I+SP++P Y + +CSW + + L F F Sbjct: 1496 GRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDF 1555 Query: 264 ELADPRDRLELRDAASGSLLR-AFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALT 322 +L + D S ++ R A R + P+ +L L F+S +GF Sbjct: 1556 DLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQ 1615 Query: 323 YR 324 +R Sbjct: 1616 FR 1617 Score = 45.1 bits (105), Expect = 1e-04 Identities = 36/120 (30%), Positives = 50/120 (41%), Gaps = 9/120 (7%) Query: 212 YEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELAD--- 267 ++ S C GN T G SP++P Y C W L G+A EL F+ F L Sbjct: 1158 WDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPN 1217 Query: 268 -PRDRLELRDAASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 D L + D S + LL G PP +R ++ + R+D +GF YR Sbjct: 1218 CTLDYLAVYDGPSSNSHLLTQLCGDEKPPL--IRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275 Score = 45.1 bits (105), Expect = 1e-04 Identities = 35/157 (22%), Positives = 66/157 (42%), Gaps = 24/157 (15%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLEL 274 V C G + G SP FP+ Y P++ C W + PG++++LT F+ +E Sbjct: 1388 VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFD-------VEY 1440 Query: 275 RDAASGSLLRAFDG------------ARPPPSGPLRLGTAA--LLLTFRSDARGHAQGFA 320 + +L + G + P P+++ + L + F++D + +GF Sbjct: 1441 HSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFN 1500 Query: 321 LTYRGLQDAAEDP-EAPEGSAQTPAAPLD-GANVSCS 355 +++ + +AP G +P P +N CS Sbjct: 1501 ASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCS 1537 Score = 44.3 bits (103), Expect = 2e-04 Identities = 36/117 (30%), Positives = 50/117 (42%), Gaps = 7/117 (5%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTFRLFELA----DPRDRL 272 +C T G I SP P+ Y NC+W L P + L F F L D L Sbjct: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990 Query: 273 ELRDAASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDA 329 E+ D S + L + G PPS L +L+L F +D+ +GF + Y + A Sbjct: 991 EVYDTDSETSLGRYCGKSIPPS--LTSSGNSLMLVFVTDSDLAYEGFLINYEAISAA 1045 Score = 43.5 bits (101), Expect = 4e-04 Identities = 36/125 (28%), Positives = 55/125 (44%), Gaps = 24/125 (19%) Query: 216 VGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLEL 274 V C N+T P G I SP++P +Y + NC++ + P + + LTF F LE Sbjct: 2917 VSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSF-------HLEA 2969 Query: 275 RDAASGS-------LLRAFDGARPP--------PSGPLRLGTAALLLTFRSDARGHAQGF 319 R A +GS ++R + P PL + +LL F S+ + GF Sbjct: 2970 RSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTI-AGPVLLNFYSNEQITDFGF 3028 Query: 320 ALTYR 324 +YR Sbjct: 3029 KFSYR 3033 Score = 40.4 bits (93), Expect = 0.003 Identities = 45/148 (30%), Positives = 63/148 (42%), Gaps = 13/148 (8%) Query: 218 SCQGN-WTAPQGVIYSPDFPDEYGPDRNCSWAL--GPPGAALELTFRLFEL----ADPRD 270 +C G+ T+ + SP FP Y ++NCSW + PP + L+F FEL RD Sbjct: 1619 ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARD 1678 Query: 271 RLELRDAA--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQD 328 +E+ D L + G P P+ ++AL L F SD+ A GF T Sbjct: 1679 FVEILDGGHEDAPLRGRYCGTDMP--HPITSFSSALTLRFVSDSSISAGGFHTTVTASVS 1736 Query: 329 AAEDP-EAPEGSAQTPAAP-LDGANVSC 354 A EG +P P + NV C Sbjct: 1737 ACGGTFYMAEGIFNSPGYPDIYPPNVEC 1764 Score = 39.7 bits (91), Expect = 0.006 Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 11/117 (9%) Query: 215 SVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPR---- 269 S C G GVI SP++P+ Y +CS L P G + LTF F++ +P Sbjct: 2685 SFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDI-EPHTTCA 2743 Query: 270 -DRLELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTY 323 D + +R+ S ++ + G P + ++ G+ L++TF SD GF T+ Sbjct: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRT--IQSGSNQLVVTFNSDHSLQGGGFYATW 2798 Score = 39.3 bits (90), Expect = 0.008 Identities = 38/152 (25%), Positives = 64/152 (42%), Gaps = 15/152 (9%) Query: 214 VSVGSCQG---NWTAPQGVIYSPDFPDEYGPDRNCSWALGPPGAALELTFRLFELADPR- 269 ++ G+C G AP ++SP +PD Y +C+W + P + +EL ++ R Sbjct: 1973 IAPGACGGFLRTGDAPV-FLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRT 2031 Query: 270 ---DRLELRDAAS--GSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYR 324 D L +RD + L G P GP+R + + F SD+ GF ++ Sbjct: 2032 CAYDSLVIRDGDNNLAQQLAVLCGREIP--GPIRSTGEYMFIRFTSDSSVTRAGFNASFH 2089 Query: 325 GLQDAAEDPEAPEGSAQTPAAP-LDGANVSCS 355 + A G +P P +N++CS Sbjct: 2090 --KSCGGYLHADRGIITSPKYPETYPSNLNCS 2119 Score = 39.3 bits (90), Expect = 0.008 Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 20/126 (15%) Query: 211 VYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADPR 269 ++ S C G +G SP +P Y + C W L P G + + F + DP Sbjct: 3503 IWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPG 3562 Query: 270 DRLELRDAASGSLLRAFDG--ARPPPSGPLRLGTAAL----------LLTFRSDARGHAQ 317 D ++ + L +DG A P SGP G ++ + F +D Sbjct: 3563 DCVQ-------NYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPS 3615 Query: 318 GFALTY 323 F LT+ Sbjct: 3616 AFRLTW 3621 Score = 37.0 bits (84), Expect = 0.038 Identities = 40/131 (30%), Positives = 52/131 (39%), Gaps = 14/131 (10%) Query: 205 GDGRLGVYEVSVGSCQGNW----TAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELT 259 G G YE +C GN G + SP+ P Y P +C W L PP ++L Sbjct: 2203 GQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQ 2262 Query: 260 FR-LFEL-ADPR---DRLELRDA--ASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDA 312 F F++ P + LELRD + +L F G P S + L FRSD Sbjct: 2263 FEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSS--QWSSGEVMYLRFRSDN 2320 Query: 313 RGHAQGFALTY 323 GF Y Sbjct: 2321 SPTHVGFKAKY 2331 Score = 36.2 bits (82), Expect = 0.064 Identities = 33/123 (26%), Positives = 48/123 (39%), Gaps = 20/123 (16%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTF-RLFELADPRDRLELR 275 SC G A +G+I SP +P+ Y + NCSW L G + + F + F++ + Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150 Query: 276 DAASGSLLRAFDGARPPPSGP---------------LRLGTAALLLTFRSDARGHAQGFA 320 D +LR PP GP L + + F SD QGF Sbjct: 2151 DYL---VLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFK 2207 Query: 321 LTY 323 + Y Sbjct: 2208 IKY 2210 Score = 35.8 bits (81), Expect = 0.084 Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 5/56 (8%) Query: 211 VYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFEL 265 VY+V+ G + +GVI SP FP+ Y +R C W + P + L F +FE+ Sbjct: 812 VYQVACG----DELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEI 863 Score = 35.8 bits (81), Expect = 0.084 Identities = 32/116 (27%), Positives = 51/116 (43%), Gaps = 10/116 (8%) Query: 218 SCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG-PPGAALELTFRLFELADP-----RDR 271 +C ++T G SP+FP+ Y + C + + G + + F F L + D Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106 Query: 272 LELRDAA--SGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRG 325 LE+RD LL F G+ PP+ + + L L F+SD GF+ + G Sbjct: 1107 LEIRDGGYEKSPLLGIFYGSNLPPT--IISHSNKLWLKFKSDQIDTRSGFSAYWDG 1160 Score = 35.8 bits (81), Expect = 0.084 Identities = 33/148 (22%), Positives = 54/148 (36%), Gaps = 23/148 (15%) Query: 212 YEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRD 270 +E S+ C G+ G SP++P+ R C W + P G + L F Sbjct: 2445 FESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNL------- 2497 Query: 271 RLELRDAASGSLLRAFDGARPPP------------SGPLRLGTAALLLTFRSDARGHAQG 318 RL + + + F+G R S ++ + + F +D G Sbjct: 2498 RLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGG 2557 Query: 319 FALTYRGLQDA---AEDPEAPEGSAQTP 343 F +Y +DA P PEG+ +P Sbjct: 2558 FTASYTSSEDAVCGGSLPNTPEGNFTSP 2585 Score = 35.0 bits (79), Expect = 0.14 Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 12/133 (9%) Query: 219 CQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDR----LE 273 C GN+T P+G ++ P+ + R C + + P G +++ F EL D +E Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767 Query: 274 LRDAASGSLLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTYRGLQDAAEDP 333 +RD +LL G ++ T ++ + F+ DA F Y Q A D Sbjct: 768 VRDGE--TLLGKVCG--NGTISHIKSITNSVWIRFKIDASVEKASFRAVY---QVACGDE 820 Query: 334 EAPEGSAQTPAAP 346 EG ++P P Sbjct: 821 LTGEGVIRSPFFP 833 Score = 34.7 bits (78), Expect = 0.19 Identities = 28/119 (23%), Positives = 53/119 (44%), Gaps = 9/119 (7%) Query: 212 YEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADP-- 268 + + C ++ G + SP +PD Y D++C+ L P + L F + + Sbjct: 3388 FTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVE 3447 Query: 269 --RDRLELRDAASGS--LLRAFDGARPPPSGPLRLGTAALLLTFRSDARGHAQGFALTY 323 D LE+R+ ++ + LL + G P P+ L L F+SD+ +G+ + + Sbjct: 3448 CRNDFLEVRNGSNSNSPLLGKYCGTLLP--NPVFSQNNELYLRFKSDSVTSDRGYEIIW 3504 Score = 32.0 bits (71), Expect = 1.2 Identities = 24/91 (26%), Positives = 36/91 (39%), Gaps = 18/91 (19%) Query: 228 GVIYSPDFPDEYGPDRNCSWAL-GPPGAALELTFRLFELADPRDRLELRDAASGSLLRAF 286 G++ S +P+ Y +++C+W + G + TF F+ LE S L + Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD-------LEHHINCSTDYLELY 1341 Query: 287 DGAR----------PPPSGPLRLGTAALLLT 307 DG R PPP LLLT Sbjct: 1342 DGPRQMGRYCGVDLPPPGSTTSSKLQVLLLT 1372 Score = 30.8 bits (68), Expect = 2.7 Identities = 16/57 (28%), Positives = 25/57 (43%), Gaps = 1/57 (1%) Query: 205 GDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSW-ALGPPGAALELTF 260 G G + C G + + G I SP +P + + CSW A+ LE++F Sbjct: 2791 GGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISF 2847 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.138 0.452 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,009,026 Number of Sequences: 37866 Number of extensions: 1293732 Number of successful extensions: 4967 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 82 Number of HSP's successfully gapped in prelim test: 127 Number of HSP's that attempted gapping in prelim test: 4472 Number of HSP's gapped (non-prelim): 486 length of query: 462 length of database: 18,247,518 effective HSP length: 106 effective length of query: 356 effective length of database: 14,233,722 effective search space: 5067205032 effective search space used: 5067205032 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.