Guide to the Human Genome
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Search of human proteins with 27436978

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27436978 potassium voltage-gated channel, Isk-related
family, member 2 [Homo sapiens]
         (123 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27436978 potassium voltage-gated channel, Isk-related family,...   248   1e-66
gi|189095241 potassium voltage-gated channel, Isk-related family...    55   1e-08
gi|189095239 potassium voltage-gated channel, Isk-related family...    55   1e-08
gi|189095237 potassium voltage-gated channel, Isk-related family...    55   1e-08
gi|60218915 potassium voltage-gated channel, Isk-related family,...    55   1e-08
gi|4885443 potassium voltage-gated channel, Isk-related family, ...    32   0.093
gi|154448884 potassium voltage-gated channel, Isk-related family...    29   0.79 
gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]         29   1.0  
gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]         29   1.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...    28   1.8  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...    28   1.8  
gi|171184451 centrosome-associated protein 350 [Homo sapiens]          28   2.3  
gi|63047871 hypothetical protein LOC122525 [Homo sapiens]              27   3.0  
gi|76496472 ribosomal protein L3 isoform b [Homo sapiens]              27   3.0  
gi|239047271 autophagy related 2A [Homo sapiens]                       27   3.9  
gi|218156307 anoctamin 6 isoform c [Homo sapiens]                      27   3.9  
gi|218156305 anoctamin 6 isoform c [Homo sapiens]                      27   3.9  
gi|218156303 anoctamin 6 isoform b [Homo sapiens]                      27   3.9  
gi|218156299 anoctamin 6 isoform a [Homo sapiens]                      27   3.9  
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa...    27   3.9  
gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa...    27   3.9  
gi|149588643 zinc finger protein 283 [Homo sapiens]                    27   3.9  
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]        27   5.1  
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]        27   5.1  
gi|47132620 keratin 2 [Homo sapiens]                                   27   5.1  
gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...    26   6.7  
gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...    26   6.7  
gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo s...    26   6.7  
gi|109134347 NY-REN-58 antigen [Homo sapiens]                          26   6.7  
gi|109134355 NY-REN-58 antigen [Homo sapiens]                          26   6.7  

>gi|27436978 potassium voltage-gated channel, Isk-related family,
           member 2 [Homo sapiens]
          Length = 123

 Score =  248 bits (632), Expect = 1e-66
 Identities = 123/123 (100%), Positives = 123/123 (100%)

Query: 1   MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF 60
           MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF
Sbjct: 1   MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF 60

Query: 61  SFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFK 120
           SFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFK
Sbjct: 61  SFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFK 120

Query: 121 MSP 123
           MSP
Sbjct: 121 MSP 123


>gi|189095241 potassium voltage-gated channel, Isk-related family,
           member 1 [Homo sapiens]
          Length = 129

 Score = 55.1 bits (131), Expect = 1e-08
 Identities = 23/51 (45%), Positives = 38/51 (74%), Gaps = 1/51 (1%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVED-WQEKYKSQI 100
           LY+++++G F F  + I++S ++SK+ EHSNDP++ YI  D WQEK K+ +
Sbjct: 45  LYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYV 95


>gi|189095239 potassium voltage-gated channel, Isk-related family,
           member 1 [Homo sapiens]
          Length = 129

 Score = 55.1 bits (131), Expect = 1e-08
 Identities = 23/51 (45%), Positives = 38/51 (74%), Gaps = 1/51 (1%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVED-WQEKYKSQI 100
           LY+++++G F F  + I++S ++SK+ EHSNDP++ YI  D WQEK K+ +
Sbjct: 45  LYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYV 95


>gi|189095237 potassium voltage-gated channel, Isk-related family,
           member 1 [Homo sapiens]
          Length = 129

 Score = 55.1 bits (131), Expect = 1e-08
 Identities = 23/51 (45%), Positives = 38/51 (74%), Gaps = 1/51 (1%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVED-WQEKYKSQI 100
           LY+++++G F F  + I++S ++SK+ EHSNDP++ YI  D WQEK K+ +
Sbjct: 45  LYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYV 95


>gi|60218915 potassium voltage-gated channel, Isk-related family,
           member 1 [Homo sapiens]
          Length = 129

 Score = 55.1 bits (131), Expect = 1e-08
 Identities = 23/51 (45%), Positives = 38/51 (74%), Gaps = 1/51 (1%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVED-WQEKYKSQI 100
           LY+++++G F F  + I++S ++SK+ EHSNDP++ YI  D WQEK K+ +
Sbjct: 45  LYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYV 95


>gi|4885443 potassium voltage-gated channel, Isk-related family,
          member 3 [Homo sapiens]
          Length = 103

 Score = 32.3 bits (72), Expect = 0.093
 Identities = 18/60 (30%), Positives = 34/60 (56%), Gaps = 4/60 (6%)

Query: 29 NTTAEQEALQAKVDAENFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYI 88
          N T E+ A     D +N Y  IL++M +   F+  + ++++   +S++ +  +DPYH YI
Sbjct: 41 NQTEERRASLPGRD-DNSYMYILFVMFL---FAVTVGSLILGYTRSRKVDKRSDPYHVYI 96


>gi|154448884 potassium voltage-gated channel, Isk-related family,
          member 4 [Homo sapiens]
          Length = 170

 Score = 29.3 bits (64), Expect = 0.79
 Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 5/55 (9%)

Query: 45 NFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVED--WQEKYK 97
          N Y+ IL +M   G+F   ++ I++  +KSKRRE  +     Y  E+  W E  K
Sbjct: 34 NEYFYILVVMSFYGIF---LIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMK 85


>gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]
          Length = 156

 Score = 28.9 bits (63), Expect = 1.0
 Identities = 12/39 (30%), Positives = 21/39 (53%)

Query: 6  NFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAE 44
          NF Q L+++  +I + ++  WR    A Q +L   VD +
Sbjct: 47 NFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLD 85


>gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]
          Length = 198

 Score = 28.9 bits (63), Expect = 1.0
 Identities = 12/39 (30%), Positives = 21/39 (53%)

Query: 6   NFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAE 44
           NF Q L+++  +I + ++  WR    A Q +L   VD +
Sbjct: 89  NFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLD 127


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
           subunit isoform b [Homo sapiens]
          Length = 2188

 Score = 28.1 bits (61), Expect = 1.8
 Identities = 15/49 (30%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 35  EALQAKVDAENFY-YVILYLMVMIGMFSFI---IVAILVSTVKSKRREH 79
           E +   +DA +FY ++   L++++G F  I   +V I     ++K+REH
Sbjct: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREH 409


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
           subunit isoform a [Homo sapiens]
          Length = 2223

 Score = 28.1 bits (61), Expect = 1.8
 Identities = 15/49 (30%), Positives = 28/49 (57%), Gaps = 4/49 (8%)

Query: 35  EALQAKVDAENFY-YVILYLMVMIGMFSFI---IVAILVSTVKSKRREH 79
           E +   +DA +FY ++   L++++G F  I   +V I     ++K+REH
Sbjct: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREH 409


>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
          Length = 3117

 Score = 27.7 bits (60), Expect = 2.3
 Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 3/37 (8%)

Query: 72  VKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKA 108
           V SKRR +  D   QYIV   +E+ + Q    EE KA
Sbjct: 584 VISKRRHYDTDEVRQYIVRQQEERKRKQ---NEEKKA 617


>gi|63047871 hypothetical protein LOC122525 [Homo sapiens]
          Length = 310

 Score = 27.3 bits (59), Expect = 3.0
 Identities = 11/30 (36%), Positives = 18/30 (60%)

Query: 6   NFTQTLEDVFRRIFITYMDNWRQNTTAEQE 35
           NFT+ LE++   I  +Y  NWR  T  +++
Sbjct: 138 NFTKNLENLMSTIQESYCSNWRCPTRVQED 167


>gi|76496472 ribosomal protein L3 isoform b [Homo sapiens]
          Length = 354

 Score = 27.3 bits (59), Expect = 3.0
 Identities = 13/62 (20%), Positives = 33/62 (53%), Gaps = 1/62 (1%)

Query: 54  MVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDW-QEKYKSQILNLEESKATIHE 112
           MV++G+  ++     + T K+   EH +D   +   ++W + K K+ ++ ++ +  T+ E
Sbjct: 84  MVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAHLMEIQVNGGTVAE 143

Query: 113 NI 114
            +
Sbjct: 144 KL 145


>gi|239047271 autophagy related 2A [Homo sapiens]
          Length = 1938

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 11/21 (52%), Positives = 15/21 (71%)

Query: 4   LSNFTQTLEDVFRRIFITYMD 24
           L  F QT+E V RRI +T++D
Sbjct: 153 LEMFAQTIETVLRRIKVTFLD 173


>gi|218156307 anoctamin 6 isoform c [Homo sapiens]
          Length = 929

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 10/57 (17%), Positives = 28/57 (49%)

Query: 46  FYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILN 102
           F++++L +  +IG+  + +   +V + K  +  +  DP  +Y+         + I++
Sbjct: 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516


>gi|218156305 anoctamin 6 isoform c [Homo sapiens]
          Length = 929

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 10/57 (17%), Positives = 28/57 (49%)

Query: 46  FYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILN 102
           F++++L +  +IG+  + +   +V + K  +  +  DP  +Y+         + I++
Sbjct: 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516


>gi|218156303 anoctamin 6 isoform b [Homo sapiens]
          Length = 892

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 10/57 (17%), Positives = 28/57 (49%)

Query: 46  FYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILN 102
           F++++L +  +IG+  + +   +V + K  +  +  DP  +Y+         + I++
Sbjct: 442 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 498


>gi|218156299 anoctamin 6 isoform a [Homo sapiens]
          Length = 910

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 10/57 (17%), Positives = 28/57 (49%)

Query: 46  FYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILN 102
           F++++L +  +IG+  + +   +V + K  +  +  DP  +Y+         + I++
Sbjct: 460 FFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIIS 516


>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
           sapiens]
          Length = 530

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 21/74 (28%), Positives = 42/74 (56%), Gaps = 3/74 (4%)

Query: 48  YVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESK 107
           Y IL+L++   +F  IIVA++V+  ++ R+E  N+   +  V+   + +K QI  ++  K
Sbjct: 320 YFILWLLLGSIIFRSIIVAMMVTNFQNIRKE-LNEEMARREVQLKADMFKRQI--IQRRK 376

Query: 108 ATIHENIGAAGFKM 121
              HE + ++  K+
Sbjct: 377 NMSHEALTSSHSKI 390


>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
           sapiens]
          Length = 528

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 21/74 (28%), Positives = 42/74 (56%), Gaps = 3/74 (4%)

Query: 48  YVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESK 107
           Y IL+L++   +F  IIVA++V+  ++ R+E  N+   +  V+   + +K QI  ++  K
Sbjct: 320 YFILWLLLGSIIFRSIIVAMMVTNFQNIRKE-LNEEMARREVQLKADMFKRQI--IQRRK 376

Query: 108 ATIHENIGAAGFKM 121
              HE + ++  K+
Sbjct: 377 NMSHEALTSSHSKI 390


>gi|149588643 zinc finger protein 283 [Homo sapiens]
          Length = 679

 Score = 26.9 bits (58), Expect = 3.9
 Identities = 16/56 (28%), Positives = 27/56 (48%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEES 106
           LY+ VM+  +S ++   L S     ++  S +   +     W+ K KS+ L LE S
Sbjct: 97  LYVDVMLENYSNLVSLDLESKTYETKKIFSENDIFEINFSQWEMKDKSKTLGLEAS 152


>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
          Length = 752

 Score = 26.6 bits (57), Expect = 5.1
 Identities = 16/51 (31%), Positives = 23/51 (45%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQIL 101
           L++ VM   F   IV +        R EH N P H  + +D  E  K+ I+
Sbjct: 321 LHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIV 371


>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
          Length = 806

 Score = 26.6 bits (57), Expect = 5.1
 Identities = 16/51 (31%), Positives = 23/51 (45%)

Query: 51  LYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQIL 101
           L++ VM   F   IV +        R EH N P H  + +D  E  K+ I+
Sbjct: 321 LHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIV 371


>gi|47132620 keratin 2 [Homo sapiens]
          Length = 639

 Score = 26.6 bits (57), Expect = 5.1
 Identities = 15/60 (25%), Positives = 28/60 (46%), Gaps = 4/60 (6%)

Query: 2   STLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMFS 61
           S L+N    +ED  ++    Y D   + T AE + +  K D +N Y + + L   + + +
Sbjct: 252 SELNNMQDLVEDYKKK----YEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLN 307


>gi|239756957 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4470

 Score = 26.2 bits (56), Expect = 6.7
 Identities = 15/48 (31%), Positives = 24/48 (50%)

Query: 13   DVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF 60
            D F RI +  +          Q+A++AK  A NF   I+ L+  +G+F
Sbjct: 1908 DEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFLGEIIGLIPTVGIF 1955


>gi|239751459 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score = 26.2 bits (56), Expect = 6.7
 Identities = 15/48 (31%), Positives = 24/48 (50%)

Query: 13   DVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF 60
            D F RI +  +          Q+A++AK  A NF   I+ L+  +G+F
Sbjct: 1885 DEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFLGEIIGLIPTVGIF 1932


>gi|239745966 PREDICTED: dynein, axonemal, heavy chain 17 [Homo
            sapiens]
          Length = 4485

 Score = 26.2 bits (56), Expect = 6.7
 Identities = 15/48 (31%), Positives = 24/48 (50%)

Query: 13   DVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMF 60
            D F RI +  +          Q+A++AK  A NF   I+ L+  +G+F
Sbjct: 1885 DEFNRISVEVLSVIAVQVKCVQDAIRAKKKAFNFLGEIIGLIPTVGIF 1932


>gi|109134347 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 26.2 bits (56), Expect = 6.7
 Identities = 12/37 (32%), Positives = 22/37 (59%), Gaps = 1/37 (2%)

Query: 78  EHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENI 114
           EH  + Y + I+++ + KY+S+I  LEE K  +   +
Sbjct: 163 EHQKEEYAR-ILDEGKIKYESEIARLEEDKEELRNQL 198


>gi|109134355 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 26.2 bits (56), Expect = 6.7
 Identities = 12/37 (32%), Positives = 22/37 (59%), Gaps = 1/37 (2%)

Query: 78  EHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENI 114
           EH  + Y + I+++ + KY+S+I  LEE K  +   +
Sbjct: 163 EHQKEEYAR-ILDEGKIKYESEIARLEEDKEELRNQL 198


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.132    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,659,389
Number of Sequences: 37866
Number of extensions: 118082
Number of successful extensions: 481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 454
Number of HSP's gapped (non-prelim): 33
length of query: 123
length of database: 18,247,518
effective HSP length: 89
effective length of query: 34
effective length of database: 14,877,444
effective search space: 505833096
effective search space used: 505833096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 55 (25.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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