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Search of human proteins with 27262626
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
(1642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 3250 0.0
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 3250 0.0
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 1219 0.0
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 1189 0.0
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 1182 0.0
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 1170 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 534 e-151
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 300 1e-80
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 300 1e-80
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 299 2e-80
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 297 5e-80
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 290 6e-78
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 290 6e-78
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 273 8e-73
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 270 1e-71
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 117 9e-26
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 117 9e-26
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 117 9e-26
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 95 6e-19
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 91 1e-17
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 91 1e-17
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 91 1e-17
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 91 1e-17
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 84 9e-16
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 84 1e-15
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 84 1e-15
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 84 1e-15
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 82 4e-15
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 82 6e-15
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 82 6e-15
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 3250 bits (8426), Expect = 0.0
Identities = 1642/1642 (100%), Positives = 1642/1642 (100%)
Query: 1 MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE
Sbjct: 1 MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
Query: 61 VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL 120
VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL
Sbjct: 61 VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL 120
Query: 121 SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI 180
SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
Sbjct: 121 SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI 180
Query: 181 DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI
Sbjct: 181 DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
Query: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF
Sbjct: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
Query: 301 LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS 360
LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
Sbjct: 301 LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS 360
Query: 361 PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV 420
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV
Sbjct: 361 PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV 420
Query: 421 IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI 480
IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI
Sbjct: 421 IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI 480
Query: 481 SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540
SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
Sbjct: 481 SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540
Query: 541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL
Sbjct: 541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
Query: 601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR 660
DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR
Sbjct: 601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR 660
Query: 661 KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT 720
KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
Sbjct: 661 KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT 720
Query: 721 ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT 780
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT
Sbjct: 721 ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT 780
Query: 781 LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW 840
LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW
Sbjct: 781 LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW 840
Query: 841 KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY 900
KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY
Sbjct: 841 KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY 900
Query: 901 FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM 960
FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM
Sbjct: 901 FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM 960
Query: 961 HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE 1020
HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE
Sbjct: 961 HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE 1020
Query: 1021 LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII 1080
LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII
Sbjct: 1021 LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII 1080
Query: 1081 LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI 1140
LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI
Sbjct: 1081 LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI 1140
Query: 1141 YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT 1200
YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT
Sbjct: 1141 YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT 1200
Query: 1201 YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD 1260
YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD
Sbjct: 1201 YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD 1260
Query: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS
Sbjct: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
Query: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
Query: 1381 QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK 1440
QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK
Sbjct: 1381 QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK 1440
Query: 1441 LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500
LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC
Sbjct: 1441 LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500
Query: 1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ 1560
DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ
Sbjct: 1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ 1560
Query: 1561 ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED 1620
ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED
Sbjct: 1561 ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED 1620
Query: 1621 NSCGTLNSTLWWERTQEDRVVF 1642
NSCGTLNSTLWWERTQEDRVVF
Sbjct: 1621 NSCGTLNSTLWWERTQEDRVVF 1642
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 3250 bits (8426), Expect = 0.0
Identities = 1642/1642 (100%), Positives = 1642/1642 (100%)
Query: 1 MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE
Sbjct: 1 MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
Query: 61 VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL 120
VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL
Sbjct: 61 VPNIELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSL 120
Query: 121 SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI 180
SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
Sbjct: 121 SKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI 180
Query: 181 DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI
Sbjct: 181 DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
Query: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF
Sbjct: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
Query: 301 LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS 360
LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
Sbjct: 301 LLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS 360
Query: 361 PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV 420
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV
Sbjct: 361 PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQV 420
Query: 421 IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI 480
IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI
Sbjct: 421 IPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRI 480
Query: 481 SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540
SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
Sbjct: 481 SGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540
Query: 541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL
Sbjct: 541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
Query: 601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR 660
DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR
Sbjct: 601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR 660
Query: 661 KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT 720
KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
Sbjct: 661 KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT 720
Query: 721 ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT 780
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT
Sbjct: 721 ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTT 780
Query: 781 LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW 840
LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW
Sbjct: 781 LEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLW 840
Query: 841 KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY 900
KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY
Sbjct: 841 KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPDLY 900
Query: 901 FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM 960
FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM
Sbjct: 901 FLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVM 960
Query: 961 HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE 1020
HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE
Sbjct: 961 HSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIE 1020
Query: 1021 LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII 1080
LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII
Sbjct: 1021 LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFII 1080
Query: 1081 LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI 1140
LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI
Sbjct: 1081 LILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFI 1140
Query: 1141 YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT 1200
YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT
Sbjct: 1141 YSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDT 1200
Query: 1201 YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD 1260
YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD
Sbjct: 1201 YNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPD 1260
Query: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS
Sbjct: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
Query: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP
Sbjct: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
Query: 1381 QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK 1440
QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK
Sbjct: 1381 QINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRK 1440
Query: 1441 LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500
LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC
Sbjct: 1441 LCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500
Query: 1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ 1560
DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ
Sbjct: 1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQ 1560
Query: 1561 ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED 1620
ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED
Sbjct: 1561 ESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEED 1620
Query: 1621 NSCGTLNSTLWWERTQEDRVVF 1642
NSCGTLNSTLWWERTQEDRVVF
Sbjct: 1621 NSCGTLNSTLWWERTQEDRVVF 1642
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 1219 bits (3153), Expect = 0.0
Identities = 684/1633 (41%), Positives = 1006/1633 (61%), Gaps = 49/1633 (3%)
Query: 6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFP-LFFLFWLILISMMHPNKKYEEVPNI 64
R + V +QT LL KN L K R K+ ++ E LF L LF + S +H ++ ++
Sbjct: 4 RRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSM 63
Query: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPS 124
+L +D F +N ++ + P + T IM KV++ + +EK M L+
Sbjct: 64 DLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLNYSI 123
Query: 125 NFVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSK-----SCEAAQYWSSGFTVLQA 178
+ V V+F D+ SY L+F + IP+ + D A C CE +++W GF QA
Sbjct: 124 DAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQA 183
Query: 179 SIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAI 238
+I+AAII++ TN S+ ++L S V M V + + +I+FS F Y++++
Sbjct: 184 AINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSV 243
Query: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIV 298
++ E++ I + +MGL ++AFWLSW L+Y I +M+ LMA+I ++ + + ++
Sbjct: 244 NVTQERQY-ITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVM 302
Query: 299 IFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVW- 357
+F LF LYGLS + A +++ L KK G+V F + V +G +G L P L W
Sbjct: 303 VFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPA-LYTRLPAFLEWT 361
Query: 358 --LFSPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLA 414
L SPF F +G+AQ++HL+ D N A + + PY +I T+ ML +++ Y++L
Sbjct: 362 LCLLSPFA---FTVGMAQLIHLDYDVNSNAHLDS-SQNPYLIIATLFMLVFDTLLYLVLT 417
Query: 415 VYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVG 474
+Y D+++P E+G R S L+FLK +W + R + E + + + ++ EPVS EF G
Sbjct: 418 LYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCG 477
Query: 475 KEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPS 534
KEAIRI ++K Y K E VEAL+ + FDIYEGQITALLGHSG GK+TL+NIL GL P+
Sbjct: 478 KEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPT 537
Query: 535 DGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE 594
G ++Y H +S + ++ K G CPQ ++ F LTV+ENL + A IKGI + + +E
Sbjct: 538 SGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE 597
Query: 595 VQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW 654
VQ+V+ +L+M+ I+D A+ LSGGQ RKL+ GIA+LG+P++LLLDEPTAG+DP SRH +W
Sbjct: 598 VQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW 657
Query: 655 NLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI 714
NLLK K++RV +FST F+DEADILADRK IS G LKC GSS+FLK KWGIGY LS+++
Sbjct: 658 NLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHL 717
Query: 715 DKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISY 774
++ C ES++SLVKQHI A L Q++++LVY LP + +KF L+ LD SN G+ Y
Sbjct: 718 NERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDY 777
Query: 775 GVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALV 834
GVS+TTL +VFLKLE ++ ID++D ++ Q + D S E+EQ L ET+ +
Sbjct: 778 GVSITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKT-I 836
Query: 835 STMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIK 894
S ++LW+QQ+ IAK F LK+E KS+ ++LLL I F Q+ L + S++ + P +
Sbjct: 837 SGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKS-YPWE 895
Query: 895 LVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM--INDSDYVSVAP 952
L P+ YFL PG +P T LL+ N S I + + QNI + + +
Sbjct: 896 LSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPS 955
Query: 953 HSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEI 1012
++ A+ V EKD+ F+ N+ + P+L+++ISN L N +E IQ + FF+E
Sbjct: 956 YNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEH 1015
Query: 1013 TDIV--FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA 1070
D ++ +F + + PY AM + ++K KA++QL++SGL PSAYW GQA
Sbjct: 1016 MDYEYGYRSNTFFWIPM----AASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQA 1071
Query: 1071 VVDIPLFFIILILM-LGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKK 1129
+VD+ L+F+IL+LM + + + F L + C IGYV S++ TY+ SF F+
Sbjct: 1072 LVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRN 1131
Query: 1130 ILNTKEFWSFIYSVAALACIAITEIT--FFMGYTIATILHYAFCIIIPIYPLLGCLISFI 1187
WSF + + + I T++ F+G T+L IP + L+G L F
Sbjct: 1132 GRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTML-------IPPFTLIGSLFIFS 1184
Query: 1188 KISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS 1247
+IS ++ + + + + +A++ PYL ++++F+L+ E + +RKDP FR +S
Sbjct: 1185 EISPDSM--DYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFR-IS 1241
Query: 1248 TKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLL 1307
+S N P P + E E+ED++ ER++ M + +E P I+ S L KEY KK
Sbjct: 1242 PRS-NAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCF 1300
Query: 1308 SRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETS 1367
S++ KK+AT+ +SFCVKKGE++GLLG NGAGKST I ++ GD +PT+GQV L + S
Sbjct: 1301 SKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL-----KGS 1355
Query: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ 1427
+ L +GYCPQ N LWP+ T+++H E+Y AVKG+ D I+R+ AL L++ L+
Sbjct: 1356 GGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLK 1415
Query: 1428 KTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
VK L GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+ IR F+N +R A+
Sbjct: 1416 APVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGAL 1475
Query: 1488 LTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ 1547
LTTHYM EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+KLK+ +++ L
Sbjct: 1476 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNL---AQMEPLH 1532
Query: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
EI +FP A++QE FSS++ YK+P EDV+ LSQ+FFKLE K +F +EEYS SQ+TLEQ
Sbjct: 1533 AEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQ 1592
Query: 1608 VFVELTKEQEEED 1620
VF+EL+KEQE D
Sbjct: 1593 VFLELSKEQELGD 1605
Score = 177 bits (448), Expect = 1e-43
Identities = 149/611 (24%), Positives = 280/611 (45%), Gaps = 48/611 (7%)
Query: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097
Y+ N + + + + GL SA+W+ ++ FI+++ L +L+ +
Sbjct: 239 YYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAG--FILIMATLMALIVKSAQIVV 296
Query: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157
T F+ V + Y S+I ++ S KK F+ + I I F
Sbjct: 297 LT-GFVMVFTLFLLYGLSLITLAFLMSVLIKK--------PFLTGLVVFLLIVFWGILGF 347
Query: 1158 MG-YT-IATILHYAFCIIIPIYPLLGCLISFIKISWK-NVRKNVDT-YNPW---DRLSVA 1210
YT + L + C++ P +G + I + + N ++D+ NP+ L +
Sbjct: 348 PALYTRLPAFLEWTLCLLSPFAFTVG-MAQLIHLDYDVNSNAHLDSSQNPYLIIATLFML 406
Query: 1211 VISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFF--RNLSTKSKNRKLPEPPDNEDEDEDV 1268
V L VL ++ + +YG R P F ++ R +NE + +
Sbjct: 407 VFDTLLYLVLTLYFDKILPAEYGHRC---SPLFFLKSCFWFQHGRANHVVLENETDSDPT 463
Query: 1269 KAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEI 1328
+ + C K +I + NL KEY K + + A K + F + +G+I
Sbjct: 464 PNDCFEPVSPEFCG----KEAIRIKNLKKEYAGKCE-------RVEALKGVVFDIYEGQI 512
Query: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSL-KCMGYCPQINPLWP 1387
LLG +GAGK+T++NIL G PTSG V + +++ D +++ K G+CPQ N +
Sbjct: 513 TALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFG 572
Query: 1388 DTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSM 1447
T++E+ ++ +KG+ ++++ + R+ L+++ + L G RKL F +++
Sbjct: 573 FLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAI 632
Query: 1448 LGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMV 1507
LG+PQ+ LLDEP+ G+DP ++ +W ++ +R + +T +++EA+ + DR +
Sbjct: 633 LGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDR--VILFSTQFIDEADILADRKVFIS 690
Query: 1508 SGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSIL 1567
+G+L+C G+ LK K+G GY L + L E + + + ++ +A L
Sbjct: 691 NGKLKCAGSSLFLKKKWGIGYHLSLHLN---ERCDPESITSLVKQHISDAKLTAQSEEKL 747
Query: 1568 AYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLN 1627
Y +P E + + L+ + IE+Y S TL +VF++L + +++ G
Sbjct: 748 VYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKLEGKSTIDESDIGI-- 804
Query: 1628 STLWWERTQED 1638
W + Q D
Sbjct: 805 ----WGQLQTD 811
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 1189 bits (3075), Expect = 0.0
Identities = 669/1553 (43%), Positives = 966/1553 (62%), Gaps = 52/1553 (3%)
Query: 110 TNEKEMLTSSLSKPSN-FVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSKS----- 162
T ++E + L K + VGV+F D+ SY L+F + IPV + + C
Sbjct: 18 TPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIKEHSEYTEHCWAMHGEIF 77
Query: 163 CEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVIL 222
C A+YW GF QA+I+AAII++ TN S+ +EL S + M +
Sbjct: 78 CYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFH 137
Query: 223 IYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMA 282
+++FS F YF ++++ E+ K K+ + +MGL ++AFWLSW L Y IF+MS+ MA
Sbjct: 138 FTCLVSFSSFIYFASLNVARERGK-FKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMA 196
Query: 283 VIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIG 342
++ T+ + + +VIF L+ LYGLS + A +++ L +K G+ F TV +G +G
Sbjct: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLG 256
Query: 343 LMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIM 402
+ L P SL W+ S F G+AQ+ HL+++ G F + + Y +I T +
Sbjct: 257 FTV-LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFI 315
Query: 403 LTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFS 462
L +++FY++ +Y ++V+P + G S L+FLK S+WSK + + E+ E +N S
Sbjct: 316 LAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSD 375
Query: 463 EIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKST 522
+ EPVS EF GKEAIRI + K Y K VEAL+ + FDIYEGQITA+LGH+G GKST
Sbjct: 376 DSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKST 435
Query: 523 LMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILAS 582
L+NIL GL ++G A+IY ++SEI +M E RK IG CPQ + FD LTV ENL + A
Sbjct: 436 LLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAK 495
Query: 583 IKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPT 642
IKGI + QEV++++++LDMQ+I+D AKKLSGGQKRKL+LGIA+LG+P++LLLDEPT
Sbjct: 496 IKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPT 555
Query: 643 AGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKS 702
AG+DP SRH VW+LLK K +R+ +FST FMDEADILADRK +S G LKC GSS+FLK
Sbjct: 556 AGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKR 615
Query: 703 KWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSA 762
KWGIGY LS++ ++ C TE ++SL+KQHIP A L +++++LVYSLP + +KF L+S
Sbjct: 616 KWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSD 675
Query: 763 LDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQS 822
LD S+ G+ +Y VS+T+L +VFL LE ++ ID+ D+ + Q+ + ++ EMEQ
Sbjct: 676 LDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQV 735
Query: 823 LLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLV 882
L L ET+ A VS+ +LW++Q+Y +A F L+RE +++ +LL+L I F + I + +
Sbjct: 736 LCSLPETRKA-VSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAF-IPIILEKI 793
Query: 883 HHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM- 941
+ + P +YFL P TSLL+ N+ S+I DL+ Q+I++ +
Sbjct: 794 MYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEID 853
Query: 942 ----INDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNV 997
N SD S ++ A+ V +KDY F+ N+ + P+L+ I+SN + N
Sbjct: 854 DFRNRNGSDDPS---YNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNF 910
Query: 998 TETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKL 1057
TE IQ+ ST F ++ DIV + + L +I + P+ M + ++K +QL +
Sbjct: 911 TELIQMESTSFSRD--DIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWI 968
Query: 1058 SGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKF-------LAVVFCLI 1110
SGL PSAYW GQA+VDIPL+F+I L + H YF + F +V C+I
Sbjct: 969 SGLWPSAYWCGQALVDIPLYFLI-------LFSIHLIYYFIFLGFQLSWELMFVLVVCII 1021
Query: 1111 GYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAF 1170
G S+I TY+ SF F+K FWSF + + L C++ ++ T L+
Sbjct: 1022 GCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFI-ILICVSTIMVS-----TQYEKLNLIL 1075
Query: 1171 CII-IPIYPLLGCLISFIKISW-KNVRKNVDTYNPWDR-LSVAVISPYLQCVLWIFLLQY 1227
C+I IP + LLG ++ I++ + +N+ + N ++ + + + PYLQ V+++F+++
Sbjct: 1076 CMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRC 1135
Query: 1228 YEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEK 1287
E KYG + KDP FR +S +S+ P P + E+EDEDV+AER++ + EE+
Sbjct: 1136 LEMKYGNEIMNKDPVFR-ISPRSRETH-PNPEEPEEEDEDVQAERVQAANALTAPNLEEE 1193
Query: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
P I S LHKEY + K S + KK+A + +SFCVKKGE+LGLLG NGAGKST I ++
Sbjct: 1194 PVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMIT 1253
Query: 1348 GDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSA 1406
G +PT+G V L G +S + D+SLK +GYCPQ N LWP T++EH E+Y AVKG+
Sbjct: 1254 GCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGK 1313
Query: 1407 SDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPK 1466
D ISR+ AL L+E L+ VK L GIKRKLCF LS+LGNP + LLDEP TGMDP+
Sbjct: 1314 EDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPE 1373
Query: 1467 AKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
+Q MW+ ++ KN++R +LTTHYM EAEAVCDR+A+MVSG LRCIG++QHLK+KFG+
Sbjct: 1374 GQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGR 1433
Query: 1527 GYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKL 1586
Y LEIK+K E +V+ L EI +FP A+ QE +SS++AYK+P EDV LS++FFKL
Sbjct: 1434 DYLLEIKMK---EPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKL 1490
Query: 1587 EEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE-RTQED 1638
E K F +EEYS SQATLEQVF+EL KEQ E N +++T+ W+ QED
Sbjct: 1491 EAMKQTFNLEEYSLSQATLEQVFLELCKEQ-ELGNVDDKIDTTVEWKLLPQED 1542
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 1182 bits (3058), Expect = 0.0
Identities = 683/1659 (41%), Positives = 1011/1659 (60%), Gaps = 82/1659 (4%)
Query: 5 IREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNI 64
+++ V++QT+ LL KN+L K R K+ S+ E + + L S N ++ +
Sbjct: 3 MKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMAPQ 62
Query: 65 ELNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHL---PDVIITEEYTNEKEMLTSSLS 121
L +DKF S+L++ YTP++N+T IM K + L VI T+ E+L +L
Sbjct: 63 NLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLP 122
Query: 122 KPSNFVGVVFKDSMSYELRFFPDMIPVSSIYM-DSRAGC-----SKSCEAAQYWSSGFTV 175
+G++F ++ SY+L FF S ++ D A C SC +YW+ GF
Sbjct: 123 YA---MGIIFNETFSYKLIFFQGYN--SPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVA 177
Query: 176 LQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYF 235
LQ +I+ AII++ TN + +EL S A+ M + + + +++ ++ FSP YF
Sbjct: 178 LQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYF 237
Query: 236 LAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSS 295
+++++ E+ KK K +K+MGL D+AFWLSW L+Y IF++S+ + +I T + + +
Sbjct: 238 ISLNVTKER-KKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTG 296
Query: 296 SIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSL 355
+VIF+LFFLYGLS V +++ L KK+ +V F +T+ +G +G + E P SL
Sbjct: 297 FMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFY-EQLPSSL 355
Query: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAV 415
W+ + F G+ Q++ L+ G F + + Y +I T ML L+ + Y+LLA+
Sbjct: 356 EWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLAL 415
Query: 416 YLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGK 475
Y D+++P S L+FL S + +R ++ E ++ + EPV+ EF GK
Sbjct: 416 YFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGK 475
Query: 476 EAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535
EAIRI ++K Y+ K VEAL+ L FDIYEGQITA+LGHSG GKS+L+NIL GL P++
Sbjct: 476 EAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTE 535
Query: 536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEV 595
G +IY +SE+ ++ E RK+ G+CPQ ++ FD+LTV+ENLS+ A IKGI + QEV
Sbjct: 536 GSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEV 595
Query: 596 QKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN 655
Q++LL+LDMQ I+DN AK LS GQKRKL+ GI +LG+P+ILLLDEPT G+DP SR VW+
Sbjct: 596 QRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWS 655
Query: 656 LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYID 715
LL+ R+A+ V +FST MDEADILADRK ++S G LKC GSSMFLK +WG+GY LS++ +
Sbjct: 656 LLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN 715
Query: 716 KYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYG 775
+ C E ++S + HIP A L +N ++LVY+LP + + F LFS LD S+ GV Y
Sbjct: 716 EICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYD 775
Query: 776 VSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVS 835
+SM+TL +VF+KLE ++ I+Q D+ + +E DS+S +EME + SE + A VS
Sbjct: 776 ISMSTLNEVFMKLEGQSTIEQ-DF-----EQVEMIRDSESLNEMELAHSSFSEMQTA-VS 828
Query: 836 TMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVH---HSFKNAVVP 892
M LW+ Q++ +A+ F LKR++K VLL LL+ F + IF +V ++ N +
Sbjct: 829 DMGLWRMQVFAMARLRFLKLKRQTK----VLLTLLLVFGIAIFPLIVENIMYAMLNEKID 884
Query: 893 IKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM-----INDSDY 947
+ +LYFL PG P + +TSLL+ N+ +S+I D I QNI++ + N +D
Sbjct: 885 WEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDG 944
Query: 948 VSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTP 1007
+S ++ A+ V +KDY F+ V N+ ++ PIL+NIISN L N T+ I+I S+P
Sbjct: 945 LS---YNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSP 1001
Query: 1008 FFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWI 1067
F ++ I L + L +++ ++ PY M + ++K A +QL +SGL SAYW
Sbjct: 1002 F--PLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWC 1059
Query: 1068 GQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLI----GYVPSVILFTYIA 1123
GQA+VD+ F +IL+LM L F+ Y + +VF L+ GY S++ F Y+
Sbjct: 1060 GQALVDVSFFILILLLM---YLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMI 1116
Query: 1124 SFTFKKILNTKEFWSFIYSVAALACIAITEITFF-MGYTIATILHYAFCIIIPIYPLLGC 1182
SF F+K WSF + A+ +IT I F + I T+ +++P Y LLG
Sbjct: 1117 SFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTM------VLVPSYTLLG- 1169
Query: 1183 LISFIKISWKNVRKNVDTYNPWDRLS--------VAVISPYLQCVLWIFLLQYYEKKYGG 1234
+F+++ ++ + Y + + + PY Q +L++F+L+ E K G
Sbjct: 1170 FKTFLEV------RDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGK 1223
Query: 1235 RSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSN 1294
+ +RKDP FR +S +S++ K P P + DEDED++ ER++ + +EKP I+ S
Sbjct: 1224 KRMRKDPVFR-ISPQSRDAK-PNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASC 1281
Query: 1295 LHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS 1354
LHKEY +K S++ KK+A + ISFCV++GEILGLLGPNGAGKS+ I ++ G +PT+
Sbjct: 1282 LHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA 1341
Query: 1355 GQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVIS 1414
G+V L SS L +GYCPQ N LWP TL+EH E+Y AVKG+ +D + I+
Sbjct: 1342 GEVELKGCSS-------VLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIA 1394
Query: 1415 RITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRA 1474
R+ A L E L V+KL AGI RKLCF LS+LGN + LLDEPSTG+DP +Q MW+A
Sbjct: 1395 RLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQA 1454
Query: 1475 IRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKL 1534
I+ KN +R +LTTH + EAEA+CDRVAIMVSG+LRCIG++QHLK+K GK Y LE+K+
Sbjct: 1455 IQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKV 1514
Query: 1535 KDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFA 1594
K E +V + EI +FP A+ QE +SS+L YK+P DV LSQ+F KLE KH F
Sbjct: 1515 K---ETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFN 1571
Query: 1595 IEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE 1633
+EEYS SQ TLE+VF+EL+KEQ E N +++T+ W+
Sbjct: 1572 LEEYSLSQCTLEKVFLELSKEQ-EVGNFDEEIDTTMRWK 1609
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 1170 bits (3026), Expect = 0.0
Identities = 658/1628 (40%), Positives = 978/1628 (60%), Gaps = 82/1628 (5%)
Query: 6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIE 65
R++ V +QT LL KN+L K R K+ S+ E L L L L + H + + ++
Sbjct: 4 RKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD 63
Query: 66 LNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSN 125
L +D F S + YTPVTN T IM KV++ +E+ + + + P
Sbjct: 64 LGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEE 123
Query: 126 FVGVVFKDSMSYELRFFPDM-IPVSSIYMDSRAGCSKS-----CEAAQYWSSGFTVLQAS 179
V V F ++ SY L+F +P + D A C ++ CE + +W GF LQA+
Sbjct: 124 IVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAA 183
Query: 180 IDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIH 239
I+AAII++ TN S+ +EL S M + + + L +I+FS F Y+ +++
Sbjct: 184 INAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYASVN 243
Query: 240 IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299
+ E+ K++K + +MGL D+AFWLSW LLY IF+M+L +A++ ++ S +V+
Sbjct: 244 VTRER-KRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFMVV 302
Query: 300 FLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLF 359
F LF LYGLS V A +++ L KKS G+V F +TV +G +G L P SL W+
Sbjct: 303 FSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-LYRHLPASLEWIL 361
Query: 360 SPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLD 418
S F++G+AQ++HL+ D N A F + + G ++ T ML ++ Y+ LA+Y +
Sbjct: 362 SLLSPFAFMLGMAQLLHLDYDLNSNA-FPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
Query: 419 QVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAI 478
+++P E+G RR L+FLK S+WS++++ E ++ + SF + E EF GKEAI
Sbjct: 421 KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI 480
Query: 479 RISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFA 538
RI + K Y+ K + +EAL++L FDIYEGQITA+LGHSG GKSTL+NIL GL P+ G
Sbjct: 481 RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540
Query: 539 SIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV 598
+IY +++SE+ ++ K+ G+CPQ ++ FD LTV ENL + A IKGI + QEV K
Sbjct: 541 TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGI----LPQEVDK- 595
Query: 599 LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658
+I LLDEPTAG+DP SRH VWNLLK
Sbjct: 596 -----------------------------------EIFLLDEPTAGLDPFSRHQVWNLLK 620
Query: 659 YRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYC 718
RK +RV +FST FMDEADILADRK +SQG LKC GSS+FLK KWGIGY LS+ +++ C
Sbjct: 621 ERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEIC 680
Query: 719 ATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSM 778
E+++SLVKQHIP A L +++ +L+Y+LP + +KF L+ LDS+ +LG+ +YGVSM
Sbjct: 681 VEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSM 740
Query: 779 TTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMS 838
TTL +VFLKLE ++ I+++D ++ + E+ D++ EMEQ L L++ + + ++
Sbjct: 741 TTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKT-IGGVA 799
Query: 839 LWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPD 898
LW+QQ+ IA+ LK E K++ ++LL+L+ F + + + ++N+ +L P
Sbjct: 800 LWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYT-WELSPH 858
Query: 899 LYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIM--VTMINDSDYVSVAPHSAA 956
LYFL PG +PH T LL+ N + I D I QNI V + ++ A
Sbjct: 859 LYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGA 918
Query: 957 LNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIV 1016
+ V +EK+Y F+ N+ + P+L++I+SN L + + I+ + F + D
Sbjct: 919 ITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNP 978
Query: 1017 FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPL 1076
Y L ++ ++ PPY AM + +++K +A +QL++SGL PSAYW GQA+VD+ L
Sbjct: 979 IGFLAYIMFWL--VLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSL 1036
Query: 1077 FFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEF 1136
+F++ + + ++ T+ + + C +GY S+I TY+ SF F+K
Sbjct: 1037 YFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
Query: 1137 WSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNV-- 1194
WSF + V + +A + F + + + F +IP ++GCL + + ++
Sbjct: 1097 WSFCFYVVTVFSVAGFAFSIF-----ESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFS 1151
Query: 1195 --RKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKN 1252
R +V + + + P+L ++++F L+ E K+G +S+RKDPFFR S
Sbjct: 1152 EERMDVQPF-------LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDV 1204
Query: 1253 RKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVK 1312
+ PE P E EDEDV+ ER++ + +EKP I+ S L KEY K+ S++
Sbjct: 1205 CQNPEEP--EGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKN 1262
Query: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372
K+AT+ +SFCV+KGE+LGLLG NGAGKST I ++ GD +PT+GQV L + S D+
Sbjct: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLL-----KGSGGGDA 1317
Query: 1373 LKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKK 1432
L+ +GYCPQ N LWP+ T+++H E+Y AVKG+ D + I+R+ AL L++ L+ VK
Sbjct: 1318 LEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKT 1377
Query: 1433 LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHY 1492
L GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+AIR F+N +R A+LTTHY
Sbjct: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
Query: 1493 MEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQY 1552
M EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+K+K+ +V+ L EI
Sbjct: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNL---AQVEPLHAEILR 1494
Query: 1553 IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVEL 1612
+FP A+RQE +SS++ YK+P EDVQ L+Q+FFKLE+ K +F +EEYS SQ+TLEQVF+EL
Sbjct: 1495 LFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLEL 1554
Query: 1613 TKEQEEED 1620
+KEQE D
Sbjct: 1555 SKEQELGD 1562
Score = 143 bits (360), Expect = 2e-33
Identities = 145/620 (23%), Positives = 260/620 (41%), Gaps = 94/620 (15%)
Query: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097
Y+A N + + + + GL SA+W+ ++ FI+ + + L +
Sbjct: 238 YYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA---LVIRSTQFI 294
Query: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157
F+ V + Y S++ ++ S KK SF+ L +T
Sbjct: 295 ILSGFMVVFSLFLLYGLSLVALAFLMSILVKK--------SFL---TGLVVFLLTVFWGC 343
Query: 1158 MGYT-----IATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVI 1212
+G+T + L + ++ P +LG + + + + ++ N + P D ++ V
Sbjct: 344 LGFTSLYRHLPASLEWILSLLSPFAFMLG-MAQLLHLDY-DLNSNAFPH-PSDGSNLIVA 400
Query: 1213 SPYL---QCVLWIFLLQYYEK----KYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDED 1265
+ ++ L++ L Y+EK +YG R R FF S S+ +K ++ D
Sbjct: 401 TNFMLAFDTCLYLALAIYFEKILPNEYGHR--RPPLFFLKSSFWSQTQKTDHVALEDEMD 458
Query: 1266 EDVKAE---RLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFC 1322
D E G K +I + N+ KEY K D K A K + F
Sbjct: 459 ADPSFHDSFEQAPPEFQG------KEAIRIRNVTKEYKGKPD-------KIEALKDLVFD 505
Query: 1323 VKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQ 1381
+ +G+I +LG +GAGKST++NIL G PT G V + + SE ++ ++ K G CPQ
Sbjct: 506 IYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQ 565
Query: 1382 INPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKL 1441
N + T++E+ ++ +KG+ LP + +
Sbjct: 566 SNVQFDFLTVRENLRLFAKIKGI----------------------------LPQEVDK-- 595
Query: 1442 CFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCD 1501
+I LLDEP+ G+DP ++ +W ++ + R + +T +M+EA+ + D
Sbjct: 596 ----------EIFLLDEPTAGLDPFSRHQVWNLLKE--RKTDRVILFSTQFMDEADILAD 643
Query: 1502 RVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQE 1561
R + G+L+C G+ LK K+G GY L ++L + + L + Q+I P+A
Sbjct: 644 RKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVK--QHI-PDAKLSA 700
Query: 1562 SFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDN 1621
L Y +P E + + L+ IE Y S TL +VF++L + ++
Sbjct: 701 KSEGKLIYTLPLERTNKFPELYKDLDSYPD-LGIENYGVSMTTLNEVFLKLEGKSTINES 759
Query: 1622 SCGTLNSTLWWERTQEDRVV 1641
L + +R+V
Sbjct: 760 DIAILGEVQAEKADDTERLV 779
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 534 bits (1376), Expect = e-151
Identities = 463/1748 (26%), Positives = 804/1748 (45%), Gaps = 191/1748 (10%)
Query: 8 VGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFF---LFWLILI--------SMMHPNK 56
+ V RQ LL KNY ++ R +V E+ PL F L WL L + ++P +
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
Query: 57 KYEEVPNIELNPM--DKFTLSNLILGYTPVTNITSSIMQKVSTDH----LPDVIITEEYT 110
+E+P P D + L+ + +T ++ + + + P E+Y
Sbjct: 61 SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI 120
Query: 111 NEKEMLTSSLSK-----PSNFVGVVFKDSMSYELRFFPDM-----IPVSSIYMDSRAG-- 158
+S L+ P N ++ Y LRF S ++ G
Sbjct: 121 RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH 180
Query: 159 ----------------CSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKA 202
S Y GF +Q ++D AI++ + + T+
Sbjct: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAA-------TRQ 233
Query: 203 VIMGETAVVEIDTFPRGV-----------ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEF 251
+ T ++ +P + + + L+++F+ +A +V EKE+++KE+
Sbjct: 234 LFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEY 293
Query: 252 LKIMGLHDTAFWLSWVLLYTSLIFL----MSLLMAVIATASLLFPQSSSIVIFLLFFL-Y 306
+++MGL W +W LL+ + + M+LL V ++ S + L F L +
Sbjct: 294 MRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCF 353
Query: 307 GLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPF 362
+S++ F+ M++ F K+ G + FF + + F+ + K L S
Sbjct: 354 AISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLS-- 411
Query: 363 CHCTFVIGIAQVMHLEDFNEGASFSNLTA-----GPYPLIITIIMLTLNSIFYVLLAVYL 417
+ +G + E G + +L + + + ML L+S+ Y L+ Y+
Sbjct: 412 -NVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYM 470
Query: 418 DQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF-SEIIEPVSSEFVGKE 476
+ V PG+FG+ + +F+ PSYW R E + + + +E E + V
Sbjct: 471 EAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVA-- 528
Query: 477 AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDG 536
I+I + K +R ++ A+R+L+ ++YEGQIT LLGH+G GK+T +++L GL PP+ G
Sbjct: 529 GIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSG 588
Query: 537 FASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
A I G+ +S+ +M + RK +G+CPQ DI FD LTV E+L A +KG+ +EV+
Sbjct: 589 RAYISGYEISQ--DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVK 646
Query: 597 KVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL 656
++L + ++ +++++ LSGG +RKLS+GIA++ K+L+LDEPT+GMD SR +W+L
Sbjct: 647 QMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL 706
Query: 657 LKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK 716
L+ +K++R V +THFMDEAD+L DR A++++G L+C GSS+FLK K+G GY +++ +
Sbjct: 707 LQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEP 766
Query: 717 YCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALD-SHSNLGVISYG 775
+C E +S LV H+P ATL +L + LP + +F GLF+ L+ LG+ S+G
Sbjct: 767 HCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFG 826
Query: 776 VSMTTLEDVFLKLE--VEAEIDQADYSVFTQQPLEEE------MDSKSFDEMEQS----L 823
S+TT+E+VFL++ V++ +D + Q E +DS M+ S
Sbjct: 827 ASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGA 886
Query: 824 LILSETKAALVST-MSLWKQQMYTIAKFHFFTLKRESKSVRS---------VLLLLLIFF 873
LI E A ++T ++L QQ + + RE K V + L LL I +
Sbjct: 887 LIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINY 946
Query: 874 TVQIF----MFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSD----- 924
+ ++F + L + VVP F PG + S L+++ ++
Sbjct: 947 SSELFDDPMLRLTLGEYGRTVVP--------FSVPGTSQLGQQLSEHLKDALQAEGQEPR 998
Query: 925 --ISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPI 982
+ DL F I + + +A+ + V A+FN+ +S
Sbjct: 999 EVLGDLEEFL----IFRASVEGGGFNERCLVAASFRDVGERT--VVNALFNNQAYHSPAT 1052
Query: 983 LVNIISNYYLY-----HLNVTETIQIWSTPFFQEITDIVFKIELYFQAAL-LGIIVTAMP 1036
+ ++ N H ++ + Q D + F AL L + +
Sbjct: 1053 ALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLA 1112
Query: 1037 PYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLY 1096
F++ ++A +SG+ +++W+ + D+ F I +L+L AF +
Sbjct: 1113 STFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAF 1172
Query: 1097 FYTVKFLAVVFCLIGYVPSVILFTYIASFTF---KKILNTKEFWSFIYSVAALACIAITE 1153
+ L+ Y ++I Y+ +F F ++ + +A + I
Sbjct: 1173 TRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMR 1232
Query: 1154 ITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVR-----------------K 1196
I ++ L + F +++P + LG +S +++ R +
Sbjct: 1233 IPAVKLEELSKTLDHVF-LVLPNH-CLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQ 1290
Query: 1197 NVDTYNPWDRLSVA--VISPYLQCVLWIFLLQYYEKKYGGR------SIRKDPFFRNLST 1248
+ + W V V S ++ LL E R ++R+ L T
Sbjct: 1291 YQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYT 1350
Query: 1249 KSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLS 1308
++P P ED+DV ER ++ L +++ L K Y+
Sbjct: 1351 -----RMPVLP----EDQDVADERTRI--LAPSPDSLLHTPLIIKELSKVYE-------- 1391
Query: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSE 1368
++V +A +S V+KGE GLLG NGAGK+T +L G+ TSG F+G + +S+
Sbjct: 1392 QRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRI-SSD 1450
Query: 1369 DDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQK 1428
+ +GYCPQ + L T +E +Y ++G+ + + L L+ H K
Sbjct: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
Query: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
V+ G KRKL ++++G P + LDEPSTGMDP A++ +W + A ++ K A I+
Sbjct: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGK-AIII 1569
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQR 1548
T+H MEE EA+C R+AIMV GQ +C+G+ QHLKSKFG GY L K++ + ++ +
Sbjct: 1570 TSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKA 1629
Query: 1549 EIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQV 1608
+ FP + ++ ++ Y +P D+ S ++ F LE+AK + +++YS SQ +LEQV
Sbjct: 1630 FVDLTFPGSVLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQV 1688
Query: 1609 FVELTKEQ 1616
F+ Q
Sbjct: 1689 FLSFAHLQ 1696
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 300 bits (767), Expect = 1e-80
Identities = 198/608 (32%), Positives = 316/608 (51%), Gaps = 63/608 (10%)
Query: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLL-YTSLIFLMSLLMAVIATASLLFPQSSSI 297
HIVAEKE ++KE +K MGL++ W++W + + L ++ L A++ +L S +
Sbjct: 726 HIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLM-HSHVV 784
Query: 298 VIFLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIIL----IE 349
+I+L +Y ++++ F +++ L+ K+K GI+ F V + ++ + + I
Sbjct: 785 IIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKIT 844
Query: 350 SFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLT 404
+F K + L S F +G E G + + P + L++ + ML
Sbjct: 845 AFEKCIASLMST---TAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 901
Query: 405 LNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRN--YEELSEGNVNGNISFS 462
++++ Y +L Y++ V PG +GL R + L+ SYW S R +E +S
Sbjct: 902 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 961
Query: 463 EIIEPVSSEFVGKEAIR--------------ISGIQKTYRKKGENVEALRNLSFDIYEGQ 508
E + + E E R + + K Y K + AL LS ++YE Q
Sbjct: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQ 1019
Query: 509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHF 568
+ + LGH+G GK+T M+IL GL PP+ G A+IYGH + EM E RK +G+CPQ ++ F
Sbjct: 1020 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT--EMDEIRKNLGMCPQHNVLF 1077
Query: 569 DVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIA 628
D LTVEE+L + +K + I +E+ K++ DL++ + + + LSGG KRKLS+ IA
Sbjct: 1078 DRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIA 1137
Query: 629 VLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQ 688
+G + ++LDEPTAG+DP +R +W+L+ K R + STH MDEAD+L DR A+IS
Sbjct: 1138 FVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISH 1197
Query: 689 GMLKCVGSSMFLKSKWGIGYRLSMYID----------------------KYCATESLSSL 726
G LKC GS +FLK +G GYRL++ C+ +S
Sbjct: 1198 GKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQF 1257
Query: 727 VKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSGLFSALD-SHSNLGVISYGVSMTTLED 783
+++H+ L+ +L Y LP + K F LF L+ S L + S+G+ TTLE+
Sbjct: 1258 IRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1317
Query: 784 VFLKLEVE 791
VFLK+ E
Sbjct: 1318 VFLKVSEE 1325
Score = 238 bits (608), Expect = 3e-62
Identities = 199/699 (28%), Positives = 315/699 (45%), Gaps = 115/699 (16%)
Query: 972 FNSTMVYSLPILVNIISNYYL-------------YHLNVT-----ETIQIWSTPFFQEIT 1013
+N+ +S+P +N ++N L Y + VT +T S + + T
Sbjct: 1732 YNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT 1791
Query: 1014 DIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVD 1073
D+V I + + ++ +P F + KA +SG P YW+ V D
Sbjct: 1792 DVVIAIFII-------VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
Query: 1074 IPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNT 1133
+ + + + L F Y F AV+ + Y S+ Y ASF F+
Sbjct: 1845 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFE----- 1899
Query: 1134 KEFWSFIYSVAALACIAITEITFFMGYT--IATILHYAF-----CIIIPIYPLLGCLISF 1186
V + A + + I F+G T +AT L F ++ Y L C + F
Sbjct: 1900 ---------VPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSY-LKSCFLIF 1949
Query: 1187 IKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNL 1246
YN L + Y+ +YY K G K PF ++
Sbjct: 1950 ------------PNYNLGHGLMEMAYNEYIN--------EYYAK-IGQFDKMKSPFEWDI 1988
Query: 1247 STKS------------------------KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQ 1282
T+ + +++P ++D DV +ER +V L G
Sbjct: 1989 VTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRV--LRGDA 2046
Query: 1283 CCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-ATKYISFCVKKGEILGLLGPNGAGKST 1341
+ + + NL K Y SRK+ ++ A + V+ GE GLLG NGAGK++
Sbjct: 2047 ---DNDMVKIENLTKVYK-------SRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2096
Query: 1342 IINILVGDIEPTSGQVFLGDYS--SETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
+L GD T G+ F+ +S E + SL GYCPQ + L+ + T +EH ++Y
Sbjct: 2097 TFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL---GYCPQCDALFDELTAREHLQLYT 2153
Query: 1400 AVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEP 1459
++G+S D V+ L+L ++ K G KRKL A++++G P LDEP
Sbjct: 2154 RLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP 2213
Query: 1460 STGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQH 1519
+TGMDPKA++ +W I K R+ +LT+H MEE EA+C R+AIMV+G+LRC+G++QH
Sbjct: 2214 TTGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQH 2272
Query: 1520 LKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSL 1579
LK++FG GY + ++ K + V + R FP A +E + + Y++ E + SL
Sbjct: 2273 LKNRFGDGYMITVRTK---SSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SL 2328
Query: 1580 SQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
+Q F K+E+ IE+YS SQ TL+ VFV K+Q +
Sbjct: 2329 AQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSD 2367
Score = 179 bits (454), Expect = 2e-44
Identities = 156/600 (26%), Positives = 273/600 (45%), Gaps = 67/600 (11%)
Query: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---WVLLY-----T 271
VI I++++A S + +VAEK K K + G + +WL+ W +L T
Sbjct: 1794 VIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPAT 1853
Query: 272 SLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLS----------------SVFFAL 315
+ ++ + T+ FP + LF LYG S S + L
Sbjct: 1854 CCVIILFVFDLPAYTSPTNFP-----AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1908
Query: 316 MLTPLFKKSKHVGIVEFFVTVAFGFIGLM-----IILIESFPKSLVWLFSPFCHCTFVIG 370
++ LF +GI TVA + L + ++ S+ KS +F + G
Sbjct: 1909 IVINLF-----IGIT---ATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNY---NLGHG 1957
Query: 371 IAQVMHLEDFNEG-ASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRR 429
+ ++ + E NE A P I+ L +A+ ++ V+ +
Sbjct: 1958 LMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGL-------VAMAVEGVVGFLLTIMC 2010
Query: 430 SSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYR- 488
+ +P S + E+ ++ + + V + ++I + K Y+
Sbjct: 2011 QYNFLRRPQRMPVSTKPVED--------DVDVASERQRVLRGDADNDMVKIENLTKVYKS 2062
Query: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
+K + A+ L + G+ LLG +G GK++ +L G + G A + GH V +
Sbjct: 2063 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV--L 2120
Query: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK 608
E+ + ++ +G CPQ D FD LT E+L + ++GI + + V+ L L++
Sbjct: 2121 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYA 2180
Query: 609 DNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL-LKYRKANRVTV 667
D A SGG KRKLS IA++G P + LDEPT GMDP +R +WNL L K R V
Sbjct: 2181 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVV 2240
Query: 668 FSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLV 727
++H M+E + L R A++ G L+C+GS LK+++G GY +++ + + +
Sbjct: 2241 LTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFF 2300
Query: 728 KQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
++ P A L +++ ++ Y L + + + +FS ++ S LG+ Y VS TTL++VF+
Sbjct: 2301 NRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFV 2359
Score = 161 bits (408), Expect = 4e-39
Identities = 158/633 (24%), Positives = 278/633 (43%), Gaps = 86/633 (13%)
Query: 1045 ENHKIKAYTQLKLSGLLPSAYWI-----GQAVVDIPLFFIILILMLGSLLAFHYGLYFYT 1099
+ H++K +K GL + +W+ G + I + + IL G +L + + +
Sbjct: 731 KEHRLKEV--MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWL 788
Query: 1100 VKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYS--------VAALACIAI 1151
FLAV Y + I+F ++ S + K IY VA +A
Sbjct: 789 --FLAV------YAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840
Query: 1152 TEITFFMGYTIATILHYAFCI---IIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLS 1208
+IT F + + AF + +Y + G I + S V D +N L
Sbjct: 841 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEG--DDFN----LL 894
Query: 1209 VAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS---------TKSKNRKLPEPP 1259
+AV + V++ L Y E + G P++ L T++ P
Sbjct: 895 LAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAR 954
Query: 1260 DNE----DEDEDVKAERLKVKELMGCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRK 1310
+ED+ E + +E G EE+P+ + V L K Y D K
Sbjct: 955 TPRLSVMEEDQACAMESRRFEETRGM---EEEPTHLPLVVCVDKLTKVYKDDK------- 1004
Query: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
K+A +S + + +++ LG NGAGK+T ++IL G PTSG + + T E D
Sbjct: 1005 --KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMD 1061
Query: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
+ K +G CPQ N L+ T++EH Y +K M+ +++ + ++ L+L V
Sbjct: 1062 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLV 1121
Query: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
+ L G+KRKL A++ +G + +LDEP+ G+DP A++ +W I R +L+T
Sbjct: 1122 QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLST 1179
Query: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDW------------- 1537
H+M+EA+ + DR+AI+ G+L+C G+ LK +G GY L + +
Sbjct: 1180 HHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASS 1239
Query: 1538 ------IENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEA 1589
+ + ++ + I+ + S+ L+Y +P E + + + F LE +
Sbjct: 1240 PPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERS 1299
Query: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
A + + TLE+VF+++++E + +NS
Sbjct: 1300 LDALHLSSFGLMDTTLEEVFLKVSEEDQSLENS 1332
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 300 bits (767), Expect = 1e-80
Identities = 198/608 (32%), Positives = 316/608 (51%), Gaps = 63/608 (10%)
Query: 239 HIVAEKEKKIKEFLKIMGLHDTAFWLSWVLL-YTSLIFLMSLLMAVIATASLLFPQSSSI 297
HIVAEKE ++KE +K MGL++ W++W + + L ++ L A++ +L S +
Sbjct: 756 HIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLM-HSHVV 814
Query: 298 VIFLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIIL----IE 349
+I+L +Y ++++ F +++ L+ K+K GI+ F V + ++ + + I
Sbjct: 815 IIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKIT 874
Query: 350 SFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLT 404
+F K + L S F +G E G + + P + L++ + ML
Sbjct: 875 AFEKCIASLMST---TAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 931
Query: 405 LNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRN--YEELSEGNVNGNISFS 462
++++ Y +L Y++ V PG +GL R + L+ SYW S R +E +S
Sbjct: 932 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 991
Query: 463 EIIEPVSSEFVGKEAIR--------------ISGIQKTYRKKGENVEALRNLSFDIYEGQ 508
E + + E E R + + K Y K + AL LS ++YE Q
Sbjct: 992 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQ 1049
Query: 509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHF 568
+ + LGH+G GK+T M+IL GL PP+ G A+IYGH + EM E RK +G+CPQ ++ F
Sbjct: 1050 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT--EMDEIRKNLGMCPQHNVLF 1107
Query: 569 DVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIA 628
D LTVEE+L + +K + I +E+ K++ DL++ + + + LSGG KRKLS+ IA
Sbjct: 1108 DRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIA 1167
Query: 629 VLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQ 688
+G + ++LDEPTAG+DP +R +W+L+ K R + STH MDEAD+L DR A+IS
Sbjct: 1168 FVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISH 1227
Query: 689 GMLKCVGSSMFLKSKWGIGYRLSMYID----------------------KYCATESLSSL 726
G LKC GS +FLK +G GYRL++ C+ +S
Sbjct: 1228 GKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQF 1287
Query: 727 VKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSGLFSALD-SHSNLGVISYGVSMTTLED 783
+++H+ L+ +L Y LP + K F LF L+ S L + S+G+ TTLE+
Sbjct: 1288 IRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1347
Query: 784 VFLKLEVE 791
VFLK+ E
Sbjct: 1348 VFLKVSEE 1355
Score = 238 bits (608), Expect = 3e-62
Identities = 199/699 (28%), Positives = 315/699 (45%), Gaps = 115/699 (16%)
Query: 972 FNSTMVYSLPILVNIISNYYL-------------YHLNVT-----ETIQIWSTPFFQEIT 1013
+N+ +S+P +N ++N L Y + VT +T S + + T
Sbjct: 1762 YNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQGT 1821
Query: 1014 DIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVD 1073
D+V I + + ++ +P F + KA +SG P YW+ V D
Sbjct: 1822 DVVIAIFII-------VAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1874
Query: 1074 IPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNT 1133
+ + + + L F Y F AV+ + Y S+ Y ASF F+
Sbjct: 1875 MLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFE----- 1929
Query: 1134 KEFWSFIYSVAALACIAITEITFFMGYT--IATILHYAF-----CIIIPIYPLLGCLISF 1186
V + A + + I F+G T +AT L F ++ Y L C + F
Sbjct: 1930 ---------VPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSY-LKSCFLIF 1979
Query: 1187 IKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNL 1246
YN L + Y+ +YY K G K PF ++
Sbjct: 1980 ------------PNYNLGHGLMEMAYNEYIN--------EYYAK-IGQFDKMKSPFEWDI 2018
Query: 1247 STKS------------------------KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQ 1282
T+ + +++P ++D DV +ER +V L G
Sbjct: 2019 VTRGLVAMAVEGVVGFLLTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRV--LRGDA 2076
Query: 1283 CCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-ATKYISFCVKKGEILGLLGPNGAGKST 1341
+ + + NL K Y SRK+ ++ A + V+ GE GLLG NGAGK++
Sbjct: 2077 ---DNDMVKIENLTKVYK-------SRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2126
Query: 1342 IINILVGDIEPTSGQVFLGDYS--SETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
+L GD T G+ F+ +S E + SL GYCPQ + L+ + T +EH ++Y
Sbjct: 2127 TFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSL---GYCPQCDALFDELTAREHLQLYT 2183
Query: 1400 AVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEP 1459
++G+S D V+ L+L ++ K G KRKL A++++G P LDEP
Sbjct: 2184 RLRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEP 2243
Query: 1460 STGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQH 1519
+TGMDPKA++ +W I K R+ +LT+H MEE EA+C R+AIMV+G+LRC+G++QH
Sbjct: 2244 TTGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQH 2302
Query: 1520 LKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSL 1579
LK++FG GY + ++ K + V + R FP A +E + + Y++ E + SL
Sbjct: 2303 LKNRFGDGYMITVRTK---SSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHI-SL 2358
Query: 1580 SQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
+Q F K+E+ IE+YS SQ TL+ VFV K+Q +
Sbjct: 2359 AQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSD 2397
Score = 179 bits (454), Expect = 2e-44
Identities = 156/600 (26%), Positives = 273/600 (45%), Gaps = 67/600 (11%)
Query: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---WVLLY-----T 271
VI I++++A S + +VAEK K K + G + +WL+ W +L T
Sbjct: 1824 VIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPAT 1883
Query: 272 SLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLS----------------SVFFAL 315
+ ++ + T+ FP + LF LYG S S + L
Sbjct: 1884 CCVIILFVFDLPAYTSPTNFP-----AVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFL 1938
Query: 316 MLTPLFKKSKHVGIVEFFVTVAFGFIGLM-----IILIESFPKSLVWLFSPFCHCTFVIG 370
++ LF +GI TVA + L + ++ S+ KS +F + G
Sbjct: 1939 IVINLF-----IGIT---ATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNY---NLGHG 1987
Query: 371 IAQVMHLEDFNEG-ASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRR 429
+ ++ + E NE A P I+ L +A+ ++ V+ +
Sbjct: 1988 LMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGL-------VAMAVEGVVGFLLTIMC 2040
Query: 430 SSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYR- 488
+ +P S + E+ ++ + + V + ++I + K Y+
Sbjct: 2041 QYNFLRRPQRMPVSTKPVED--------DVDVASERQRVLRGDADNDMVKIENLTKVYKS 2092
Query: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
+K + A+ L + G+ LLG +G GK++ +L G + G A + GH V +
Sbjct: 2093 RKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSV--L 2150
Query: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK 608
E+ + ++ +G CPQ D FD LT E+L + ++GI + + V+ L L++
Sbjct: 2151 KELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYA 2210
Query: 609 DNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL-LKYRKANRVTV 667
D A SGG KRKLS IA++G P + LDEPT GMDP +R +WNL L K R V
Sbjct: 2211 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVV 2270
Query: 668 FSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLV 727
++H M+E + L R A++ G L+C+GS LK+++G GY +++ + + +
Sbjct: 2271 LTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFF 2330
Query: 728 KQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
++ P A L +++ ++ Y L + + + +FS ++ S LG+ Y VS TTL++VF+
Sbjct: 2331 NRNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFV 2389
Score = 161 bits (408), Expect = 4e-39
Identities = 158/633 (24%), Positives = 278/633 (43%), Gaps = 86/633 (13%)
Query: 1045 ENHKIKAYTQLKLSGLLPSAYWI-----GQAVVDIPLFFIILILMLGSLLAFHYGLYFYT 1099
+ H++K +K GL + +W+ G + I + + IL G +L + + +
Sbjct: 761 KEHRLKEV--MKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWL 818
Query: 1100 VKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYS--------VAALACIAI 1151
FLAV Y + I+F ++ S + K IY VA +A
Sbjct: 819 --FLAV------YAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 870
Query: 1152 TEITFFMGYTIATILHYAFCI---IIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLS 1208
+IT F + + AF + +Y + G I + S V D +N L
Sbjct: 871 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEG--DDFN----LL 924
Query: 1209 VAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLS---------TKSKNRKLPEPP 1259
+AV + V++ L Y E + G P++ L T++ P
Sbjct: 925 LAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAR 984
Query: 1260 DNE----DEDEDVKAERLKVKELMGCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRK 1310
+ED+ E + +E G EE+P+ + V L K Y D K
Sbjct: 985 TPRLSVMEEDQACAMESRRFEETRGM---EEEPTHLPLVVCVDKLTKVYKDDK------- 1034
Query: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
K+A +S + + +++ LG NGAGK+T ++IL G PTSG + + T E D
Sbjct: 1035 --KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT-EMD 1091
Query: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
+ K +G CPQ N L+ T++EH Y +K M+ +++ + ++ L+L V
Sbjct: 1092 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLV 1151
Query: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
+ L G+KRKL A++ +G + +LDEP+ G+DP A++ +W I R +L+T
Sbjct: 1152 QTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLST 1209
Query: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDW------------- 1537
H+M+EA+ + DR+AI+ G+L+C G+ LK +G GY L + +
Sbjct: 1210 HHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASS 1269
Query: 1538 ------IENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEA 1589
+ + ++ + I+ + S+ L+Y +P E + + + F LE +
Sbjct: 1270 PPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERS 1329
Query: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
A + + TLE+VF+++++E + +NS
Sbjct: 1330 LDALHLSSFGLMDTTLEEVFLKVSEEDQSLENS 1362
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 299 bits (765), Expect = 2e-80
Identities = 239/793 (30%), Positives = 388/793 (48%), Gaps = 63/793 (7%)
Query: 173 FTVLQASIDAAIIQLKTNVSLWKELESTKAVIMG-ETAVVEIDT----FPRGVILIYLVI 227
F LQ I+ AII ++T + T+A T+ + ++ FP ++L ++V
Sbjct: 3524 FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVS 3583
Query: 228 AFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATA 287
S + +V E+E +I+E++++MG+H +L+W L +++ + S +A++
Sbjct: 3584 VAS-----MVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKT 3638
Query: 288 SLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIIL 347
S +F S++ ++FL +G+S V + +L+ F ++ + V + F+ +++L
Sbjct: 3639 SGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYM-ISFLPYIVLL 3697
Query: 348 IESFPKSLV--WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN----LTAGPYPLIITII 401
+ S V F G+ + LE G ++N L G
Sbjct: 3698 VLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCW 3757
Query: 402 MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF 461
M+ +S Y L YL +IPG FGLR+ + SYW E+ + F
Sbjct: 3758 MILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFF 3817
Query: 462 SEIIEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGH 515
+E + S +E A ++ + T +G +++LS Y QITALLG
Sbjct: 3818 NENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKA-VVQDLSLTFYRDQITALLGT 3876
Query: 516 SGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEE 575
+G GK+T++++L GL PP+ G I G + ++ R +G+CPQ DI D LTV E
Sbjct: 3877 NGAGKTTIISMLTGLHPPTSGTIIINGKNLQT--DLSRVRMELGVCPQQDILLDNLTVRE 3934
Query: 576 NLSILASIKGIP--ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNP 633
+L + ASIK + Q+V + L D+D+ + Q + LSGG KRKLSLGIA +G
Sbjct: 3935 HLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMS 3994
Query: 634 KILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLK 692
+ ++LDEPT+G+DPCSRH +W+ LLKYR+ R +F+TH +DEA+ L+DR AV+ G L+
Sbjct: 3995 RTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDEAEALSDRVAVLQHGRLR 4053
Query: 693 CVGSSMFLKSKWGIGYRLSM-----------YIDKYCATESLSSLVKQHIPGATLLQQND 741
C G LK +G G RL++ D C T SL+K +IP A L +
Sbjct: 4054 CCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVT----SLIKIYIPQAFLKDSSG 4109
Query: 742 QQLVYSLPFKDMDK--FSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQAD 798
+L Y++P KD DK GLF ALD + L + YG+S TTLE+VFL L ++ ++
Sbjct: 4110 SELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLML-LQDSNKKSH 4167
Query: 799 YSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRE 858
++ T+ L+ + SL + A V + L + Q+ I R
Sbjct: 4168 IALGTESELQNHRPTGHLSGYCGSL-----ARPATVQGVQLLRAQVAAILARRLRRTLRA 4222
Query: 859 SKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVP------DLYFLKPGDKPHKYK 912
KS + LLL ++F + + +F+V P++L P + YF G +
Sbjct: 4223 GKSTLADLLLPVLFVALAMGLFMV-RPLATEYPPLRLTPGHYQRAETYFFSSGG-DNLDL 4280
Query: 913 TSLLLQNSADSDI 925
T +LL+ D D+
Sbjct: 4281 TRVLLRKFRDQDL 4293
Score = 196 bits (497), Expect = 2e-49
Identities = 121/323 (37%), Positives = 180/323 (55%), Gaps = 19/323 (5%)
Query: 1314 VATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL----GDYSSETSED 1369
+A + IS + KGE GLLG NGAGKST +L G++ TSG + GD + + S
Sbjct: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGD-AVDLSSA 4793
Query: 1370 DDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKT 1429
+ +GYCPQ + L T EH Y +++G+ + EV + L L+ H K
Sbjct: 4794 GTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKP 4853
Query: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILT 1489
V G KRKL AL+++G P I LLDEPS+GMDP +K+++W+ I + AA+LT
Sbjct: 4854 VATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR-EGCAAVLT 4912
Query: 1490 THYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWI--ENLEVDRLQ 1547
+H MEE EA+C R+AIMV+G +C+G+ QH+K++FG GY +++ W+ E + +
Sbjct: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKV----WLCKEANQHCTVS 4968
Query: 1548 REIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
++ FP + ++L Y +PK L+ F +E K I+ YS +Q TLEQ
Sbjct: 4969 DHLKLYFPGIQFKGQHLNLLEYHVPKR-WGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027
Query: 1608 VFVELTKEQEEEDNSCGTLNSTL 1630
VF+ EQ++ TL STL
Sbjct: 5028 VFINFASEQQQ------TLQSTL 5044
Score = 177 bits (449), Expect = 7e-44
Identities = 155/606 (25%), Positives = 275/606 (45%), Gaps = 59/606 (9%)
Query: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
+ + +V+ FS + +V ++ K I GL +W + LY L +L+S+
Sbjct: 4458 VALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFT-NFLYDMLFYLVSVC 4516
Query: 281 MAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTV 336
+ V + + + LL L+G +++ + +++ +F S V F V
Sbjct: 4517 LCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSD----VAFISYV 4572
Query: 337 AFGFI-GLMIILIESFPKSLV----------------WLFSPFCHCTFVIGIAQVMHLE- 378
+ FI GL +LI P+ L W+F+ F G+ ++ + +
Sbjct: 4573 SLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQI 4632
Query: 379 --DFNEGASFSNLTAGPYPLIIT---IIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLY 433
D + + P+ + + L +LL V L + + S+L
Sbjct: 4633 KYDLTHNFGIDSYVS-PFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLL-RWPRGHSTLQ 4690
Query: 434 -FLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGE 492
+K S + ++ + + EG NG+I + + + K YR+ +
Sbjct: 4691 GTVKSSKDTDVEKEEKRVFEGRTNGDI------------------LVLYNLSKHYRRFFQ 4732
Query: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEID--E 550
N+ A++++S I +G+ LLG +G GKST +L G + G A I +D
Sbjct: 4733 NIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSS 4792
Query: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
A +IG CPQ D ++LT E+L S++GIP I + ++ L ++ D
Sbjct: 4793 AGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADK 4852
Query: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVW-NLLKYRKANRVTVFS 669
SGG KRKLS +A++G P ILLLDEP++GMDPCS+ +W ++K + V +
Sbjct: 4853 PVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912
Query: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATE-SLSSLVK 728
+H M+E + L R A++ G KC+GS +K+++G GY + +++ K ++S +K
Sbjct: 4913 SHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVSDHLK 4972
Query: 729 QHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFLK 787
+ PG Q+ L Y +P K + LF ++++ L + Y ++ TTLE VF+
Sbjct: 4973 LYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFIN 5031
Query: 788 LEVEAE 793
E +
Sbjct: 5032 FASEQQ 5037
Score = 163 bits (412), Expect = 1e-39
Identities = 112/371 (30%), Positives = 191/371 (51%), Gaps = 31/371 (8%)
Query: 1261 NEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYIS 1320
NE+ D + + + EL G P + + ++ KEY+ K + +S
Sbjct: 3818 NENFDNKGSSLQNREGELEG-----SAPGVTLVSVTKEYEGHK----------AVVQDLS 3862
Query: 1321 FCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCP 1380
+ +I LLG NGAGK+TII++L G PTSG + + + +T ++ +G CP
Sbjct: 3863 LTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRME-LGVCP 3921
Query: 1381 QINPLWPDTTLQEHFEIYGAVKG--MSASDMKEVISRITHALDLKEHLQKTVKKLPAGIK 1438
Q + L + T++EH ++ ++K + ++ + +++ +DL +H K + L G+K
Sbjct: 3922 QQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLK 3981
Query: 1439 RKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAE 1497
RKL ++ +G + +LDEP++G+DP ++ +W + K R+ R I TTH+++EAE
Sbjct: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL---LKYREGRTIIFTTHHLDEAE 4038
Query: 1498 AVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQ------REIQ 1551
A+ DRVA++ G+LRC G LK +G+G L + L LE L+ I+
Sbjct: 4039 ALSDRVAVLQHGRLRCCGPPFCLKEAYGQG--LRLTLTRQPSVLEAHDLKDMACVTSLIK 4096
Query: 1552 YIFPNASRQESFSSILAYKIPKE-DVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
P A ++S S L Y IPK+ D L F L+E H + Y S TLE+VF+
Sbjct: 4097 IYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFL 4156
Query: 1611 ELTKEQEEEDN 1621
L ++ ++ +
Sbjct: 4157 MLLQDSNKKSH 4167
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 297 bits (761), Expect = 5e-80
Identities = 221/735 (30%), Positives = 365/735 (49%), Gaps = 93/735 (12%)
Query: 164 EAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILI 223
E +Y GF LQ ++ AII++ T E V M + +P V I
Sbjct: 584 EDMRYVWGGFAYLQDVVEQAIIRVLTGT------EKKTGVYMQQMP------YPCYVDDI 631
Query: 224 YLVIAFSPFGYFLAIH-----------IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTS 272
+L + F+ + IV EKE ++KE ++IMGL ++ W SW +
Sbjct: 632 FLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLI 691
Query: 273 LIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHV----G 328
+ + + L+ VI L P S V+F+ ++ + ++ +++ LF ++ G
Sbjct: 692 PLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGG 751
Query: 329 IVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSN 388
I+ F + + + + K L SP F G E+ G + N
Sbjct: 752 IIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVA---FGFGCEYFALFEEQGIGVQWDN 808
Query: 389 LTAGP-----YPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKS 443
L P + L ++ M+ ++ Y ++ Y++ V PG++G+ R + SYW
Sbjct: 809 LFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE 868
Query: 444 KRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFD 503
+ + E+ G+ IS + E + +G + I + K YR G V A+ L+ +
Sbjct: 869 ESD-EKSHPGSNQKRISEICMEEEPTHLKLG---VSIQNLVKVYRD-GMKV-AVDGLALN 922
Query: 504 IYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQ 563
YEGQIT+ LGH+G GK+T M+IL GL PP+ G A I G + EM R+ +G+CPQ
Sbjct: 923 FYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRS--EMSTIRQNLGVCPQ 980
Query: 564 LDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIK-DNQAKKLSGGQKRK 622
++ FD+LTVEE++ A +KG+ ++ E++++ LD+ + + K ++ +LSGG +RK
Sbjct: 981 HNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRK 1040
Query: 623 LSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADR 682
LS+ +A +G K+++LDEPTAG+DP SR +W LL + R + STH MDEAD+L DR
Sbjct: 1041 LSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDR 1100
Query: 683 KAVISQGMLKCVGSSMFLKSKWGIGYRLSM--------------------YIDKYCA--- 719
A+IS G L CVGSS+FLK++ G GY L++ Y+ K +
Sbjct: 1101 IAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQ 1160
Query: 720 -------------------TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDK--FSG 758
++S+L+++H+ A L++ +L Y LP++ + F
Sbjct: 1161 SSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVE 1220
Query: 759 LFSALDSH-SNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFD 817
LF +D S+LG+ SYG+S TTLE++FLK+ E+ +D A+ S T L + ++F
Sbjct: 1221 LFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVD-AETSDGT---LPARRNRRAFG 1276
Query: 818 EMEQSLLILSETKAA 832
+ + L +E AA
Sbjct: 1277 DKQSCLRPFTEDDAA 1291
Score = 232 bits (592), Expect = 2e-60
Identities = 174/611 (28%), Positives = 290/611 (47%), Gaps = 73/611 (11%)
Query: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
+P F + + KA +SG+ P YW+ V D+ + + L++ + F
Sbjct: 1668 VPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQK 1727
Query: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Y + + L+ Y S+ Y ASF FK + + A + +T +
Sbjct: 1728 SYVSSTNLPVLALLLLLYGWSITPLMYPASFVFK--------------IPSTAYVVLTSV 1773
Query: 1155 TFFMGY--TIATILHYAFC---------------IIIPIYPLLGCLISFIK-------IS 1190
F+G ++AT + F +I P + L LI +K +
Sbjct: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
Query: 1191 WKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKS 1250
+ V + WD + + + ++ V++ + + ++ IR P LS +
Sbjct: 1834 RFGENRFVSPLS-WDLVGRNLFAMAVEGVVFFLITVLIQYRF---FIRPRPVNAKLSPLN 1889
Query: 1251 KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRK 1310
DEDEDV+ ER ++ + G + + + L K Y R+
Sbjct: 1890 ------------DEDEDVRRERQRILDGGG-----QNDILEIKELTKIY---------RR 1923
Query: 1311 VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD 1370
+K A I + GE GLLG NGAGKS+ +L GD T G FL +S S
Sbjct: 1924 KRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNK-NSILSNIH 1982
Query: 1371 DSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV 1430
+ + MGYCPQ + + T +EH E + ++G+ ++ +V L L ++ +K
Sbjct: 1983 EVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYA 2042
Query: 1431 KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
G KRKL A++++G P + LDEP+TGMDPKA++ +W + K R+ +LT+
Sbjct: 2043 GNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVK-EGRSVVLTS 2101
Query: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREI 1550
H MEE EA+C R+AIMV+G+ RC+G+VQHLK++FG GY + +++ N ++ +Q
Sbjct: 2102 HSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAG--SNPDLKPVQDFF 2159
Query: 1551 QYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV 1610
FP + +E ++L Y++P + SL++ F L ++K IE+YS SQ TL+QVFV
Sbjct: 2160 GLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
Query: 1611 ELTKEQEEEDN 1621
K+Q ++D+
Sbjct: 2219 NFAKDQSDDDH 2229
Score = 163 bits (413), Expect = 1e-39
Identities = 163/640 (25%), Positives = 283/640 (44%), Gaps = 112/640 (17%)
Query: 1055 LKLSGLLPSAYWIGQAVVD-IPLF----FIILILMLGSLLAFHY-GLYFYTVKFLAVVFC 1108
+++ GL S W + IPL +++IL LG+LL + + F + AVV
Sbjct: 671 MRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVV-- 728
Query: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
IL ++ S F + IY L + ++G+T+
Sbjct: 729 -------TILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS- 780
Query: 1169 AFCIIIPIYPLLGCLI------SFIKISWKNVRKNV---DTYNPWDRLSVAVISPYLQCV 1219
++ P+ GC I + W N+ ++ D +N +S+ + +L V
Sbjct: 781 ---LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGV 837
Query: 1220 LWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELM 1279
+ ++ + +YG I + +F TKS + DE + + ++ E+
Sbjct: 838 MTWYIEAVFPGQYG---IPRPWYFP--CTKSYWFG-----EESDEKSHPGSNQKRISEI- 886
Query: 1280 GCQCCEEKPS-----IMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGP 1334
C EE+P+ + + NL K Y D KVA ++ +G+I LG
Sbjct: 887 ---CMEEEPTHLKLGVSIQNLVKVYRDGM---------KVAVDGLALNFYEGQITSFLGH 934
Query: 1335 NGAGKSTIINILVGDIEPTSGQVFL--GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQ 1392
NGAGK+T ++IL G PTSG ++ D SE S +L G CPQ N L+ T++
Sbjct: 935 NGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNL---GVCPQHNVLFDMLTVE 991
Query: 1393 EHFEIYGAVKGMSASDMKEVISRITHALDL---KEHLQKTVKKLPAGIKRKLCFALSMLG 1449
EH Y +KG+S +K + ++ ALD+ L+ +L G++RKL AL+ +G
Sbjct: 992 EHIWFYARLKGLSEKHVKAEMEQM--ALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVG 1049
Query: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVS 1508
++ +LDEP+ G+DP +++ +W + K R+ R IL+TH+M+EA+ + DR+AI+
Sbjct: 1050 GSKVVILDEPTAGVDPYSRRGIWELL---LKYRQGRTIILSTHHMDEADVLGDRIAIISH 1106
Query: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--------------------------- 1541
G+L C+G+ LK++ G GY+L + KD +L
Sbjct: 1107 GKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAG 1166
Query: 1542 ------------EVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQ--SLSQSFFKLE 1587
+V + I+ A E L Y +P E + + + F +++
Sbjct: 1167 LGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEID 1226
Query: 1588 EAKHAFAIEEYSFSQATLEQVFVELTKEQ-EEEDNSCGTL 1626
+ I Y S+ TLE++F+++ +E + + S GTL
Sbjct: 1227 DRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTL 1266
Score = 160 bits (404), Expect = 1e-38
Identities = 155/629 (24%), Positives = 273/629 (43%), Gaps = 60/629 (9%)
Query: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLL 280
I + ++F P + + ++ E+ K K I G+ +WLS + + + L
Sbjct: 1659 ICVIFAMSFVPASF--VVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATL 1716
Query: 281 MAVIATASLLFPQSSSI------VIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFV 334
+ +I + F Q S + V+ LL LYG S + +FK +V V
Sbjct: 1717 VIIIF---ICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773
Query: 335 TVAFGFIG-LMIILIESFP-----------KSLVWLFSPFCHCTFVIGI----AQVMHLE 378
+ G G + ++E F KS+ +F FC +I + A LE
Sbjct: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833
Query: 379 DFNEGASFSNLTAGPYPLI-ITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKP 437
F E S L+ + L+ + + + + + L+ V + +F++P
Sbjct: 1834 RFGENRFVSPLS---WDLVGRNLFAMAVEGVVFFLITVLIQY------------RFFIRP 1878
Query: 438 SYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEAL 497
L++ + + I++ + + I + K YR+K + A+
Sbjct: 1879 R---PVNAKLSPLNDEDEDVRRERQRILDGGGQN----DILEIKELTKIYRRKRK--PAV 1929
Query: 498 RNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKM 557
+ I G+ LLG +G GKS+ +L G + G A + ++ S + + E +
Sbjct: 1930 DRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL--NKNSILSNIHEVHQN 1987
Query: 558 IGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSG 617
+G CPQ D ++LT E++ A ++G+P + + + + L + + A SG
Sbjct: 1988 MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSG 2047
Query: 618 GQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFSTHFMDEA 676
G KRKLS +A++G P ++ LDEPT GMDP +R +WN L K R V ++H M+E
Sbjct: 2048 GNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEEC 2107
Query: 677 DILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-DKYCATESLSSLVKQHIPGAT 735
+ L R A++ G +C+GS LK+++G GY + + I + + PG+
Sbjct: 2108 EALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSV 2167
Query: 736 LLQQNDQQLVYSLPFKDMDKFSGLFSAL-DSHSNLGVISYGVSMTTLEDVFLKLEVEAEI 794
L +++ L Y LP + + +FS L S L + Y VS TTL+ VF+ +
Sbjct: 2168 LKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSD 2226
Query: 795 DQ--ADYSVFTQQPLEEEMDSKSFDEMEQ 821
D D S+ Q + + SF + E+
Sbjct: 2227 DDHLKDLSLHKNQTVVDVAVLTSFLQDEK 2255
Score = 31.2 bits (69), Expect = 8.6
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
W Q R LL KN + R + E+ +PLF LI + + +P + E
Sbjct: 4 WPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHE 53
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 290 bits (743), Expect = 6e-78
Identities = 209/784 (26%), Positives = 385/784 (49%), Gaps = 64/784 (8%)
Query: 167 QYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLV 226
Q + F LQ SI+ AII+L+T + + +A+ T + I L+
Sbjct: 697 QIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLM 756
Query: 227 IAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIAT 286
+A+ F +V EK+ ++ E++K+MG++ + + +W++ + + +++ +I
Sbjct: 757 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 816
Query: 287 ASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMII 346
+ P+++ ++FL F Y S + + +++ F + ++ + + F ++++
Sbjct: 817 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 876
Query: 347 LIESFPKSLVWLFSPFCHCT-FVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITII---- 401
+E+ ++ +F T F + E+ G + N+ P T
Sbjct: 877 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 936
Query: 402 -MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSK---------SKRN---YE 448
++ +S Y L+A Y+ V PG +G+ + + PSYW + K N +
Sbjct: 937 CLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFT 996
Query: 449 ELSEGNVNGNIS----FSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDI 504
+ N N + S FS IEP + + + G+ K Y K A+ NL+ +
Sbjct: 997 NIMMQNTNPSASPEYMFSSNIEPEPKDLT--VGVALHGVTKIYGSK----VAVDNLNLNF 1050
Query: 505 YEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQL 564
YEG IT+LLG +G GK+T +++L GL S G +YG + ++ RK +G+C Q
Sbjct: 1051 YEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQH 1108
Query: 565 DIHFDVLTVEENLSILASIKGIP---ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKR 621
D+ F LT +E+L + SIK +P + +EV++ L D + + + + LSGG KR
Sbjct: 1109 DVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKR 1167
Query: 622 KLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILAD 681
KLS+ IA++G ++++LDEP+ G+DPCSR +W+++ K R + STH +DEA++L+D
Sbjct: 1168 KLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSD 1227
Query: 682 RKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK--------YCATESLSSLVKQHIPG 733
R A + QG L+C GS +LK +G GY L++ K C T +++++++ H+P
Sbjct: 1228 RIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPE 1287
Query: 734 ATLLQQNDQQLVYSLP---FKDMDKFSGLFSALDS-HSNLGVISYGVSMTTLEDVFLKLE 789
A L + +LVY LP K + L ALD+ +L + YG+S TT+E+VFL L
Sbjct: 1288 AYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLT 1347
Query: 790 VEAEIDQA-DYSVFTQQ------------PLEEEMDSKSFDEMEQSLLILSETKAALVST 836
E++ + A TQ+ P + + S +F + + +L T+ +
Sbjct: 1348 KESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKIL----TRGERLDG 1403
Query: 837 MSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLV 896
L +++ I F +R K + + ++L ++F T + + + +S N+ I++
Sbjct: 1404 FGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNS-SNSYPEIQIS 1462
Query: 897 PDLY 900
P LY
Sbjct: 1463 PSLY 1466
Score = 246 bits (627), Expect = 2e-64
Identities = 196/687 (28%), Positives = 323/687 (47%), Gaps = 88/687 (12%)
Query: 978 YSLPILVNIISNYYLYHLNVTET------IQIWSTPF----FQEITDIVFKIELYFQAAL 1027
+SLP +N ++N+ L +N+++ I ++S P+ QE I I++ ++
Sbjct: 1617 HSLPAYLNSLNNFLL-RVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSI 1675
Query: 1028 L-GIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLG 1086
L G VT F H+ KA +SG+ + YW+ + D+ + + + +G
Sbjct: 1676 LMGYSVTTAS--FVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIG 1733
Query: 1087 SLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAAL 1146
+ F FY+ L V L+ +LF Y A+F++ +L + ++ +
Sbjct: 1734 IIAIFKLPA-FYSENNLGAVSLLL------LLFGY-ATFSWMYLL------AGLFHETGM 1779
Query: 1147 ACIAITEITFFMGYTIATILHYAFCI-------------------IIPIYPLL------- 1180
A I + F G L + + I I+P
Sbjct: 1780 AFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 1839
Query: 1181 -----GCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGR 1235
++ F+K N + VA++S F L+ + +
Sbjct: 1840 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTM----FFSLRLLINESLIK 1895
Query: 1236 SIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNL 1295
+R FFR ++ + DEDEDV+AERL+V+ E + + L
Sbjct: 1896 KLRL--FFRKFNSSHVRETI-------DEDEDVRAERLRVES-----GAAEFDLVQLYCL 1941
Query: 1296 HKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSG 1355
K Y L+ +K+ +A IS + GE GLLG NGAGK+TI +L GDI P+SG
Sbjct: 1942 TKTYQ-----LIHKKI--IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSG 1994
Query: 1356 QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISR 1415
+ + + + D +GYCPQ + L T++EH Y V G+ D+KE + +
Sbjct: 1995 NILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHK 2054
Query: 1416 ITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAI 1475
+ L L + G KRKL AL+++G P I LLDEPS+GMDPK+K+H+W+ I
Sbjct: 2055 LLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKII 2114
Query: 1476 RTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK 1535
+N K + ILT+H MEE EA+C R+AIMV+G+ +CIG++QH+KS+FG+G+ +++ LK
Sbjct: 2115 SEEVQN-KCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLK 2173
Query: 1536 DWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAI 1595
+ + ++ L + +Q FP ++ S+L Y +P ++ F LE K A I
Sbjct: 2174 N--NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNI 2230
Query: 1596 EEYSFSQATLEQVFVELTKEQEEEDNS 1622
+ SQ TLE+VF+ K+Q+ + +
Sbjct: 2231 TNFLVSQTTLEEVFINFAKDQKSYETA 2257
Score = 202 bits (514), Expect = 2e-51
Identities = 154/594 (25%), Positives = 287/594 (48%), Gaps = 45/594 (7%)
Query: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSL 279
++ + +++ +S ++V E + K K+ I G+ T +W++ +Y + +L+ +
Sbjct: 1670 LVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPV 1728
Query: 280 LMAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVT 335
++ A P +++ + LL L+G ++ + +L LF ++ I V
Sbjct: 1729 AFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVN 1788
Query: 336 VAFGF---IGLMII--------------LIESFPKSLVWLFSPFCHCTFVIGIAQVMHLE 378
+ FG + L ++ LI K + +F FC +I ++Q +
Sbjct: 1789 LFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVL 1848
Query: 379 DFNE--GASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLK 436
DF + G + N T L + L + L + +++ + +++ L+F K
Sbjct: 1849 DFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL-----IKKLRLFFRK 1903
Query: 437 PSYWSKSKRNYEELSEGNVNGNISFSEI-IEPVSSEFVGKEAIRISGIQKTYRKKGENVE 495
S E + E ++ + +E ++EF + +++ + KTY+ + +
Sbjct: 1904 ----FNSSHVRETIDEDE---DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKKII 1953
Query: 496 ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEAR 555
A+ N+S I G+ LLG +G GK+T+ +L G PS G I ++ + +
Sbjct: 1954 AVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR-NKTGSLGHVDSHS 2012
Query: 556 KMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKL 615
++G CPQ D D++TVEE+L A + GIP +I + V K+L L + KD
Sbjct: 2013 SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMC 2072
Query: 616 SGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST-HFMD 674
S G KRKLS +A++G P ILLLDEP++GMDP S+ +W ++ N+ +V T H M+
Sbjct: 2073 SYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSME 2132
Query: 675 EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT-ESLSSLVKQHIPG 733
E + L R A++ G +C+GS +KS++G G+ + +++ T E+L+ ++ H P
Sbjct: 2133 ECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPK 2192
Query: 734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
L Q+ L Y +P + +F L+++ L + ++ VS TTLE+VF+
Sbjct: 2193 TYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2245
Score = 160 bits (404), Expect = 1e-38
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 19/319 (5%)
Query: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372
KVA ++ +G I LLGPNGAGK+T I++L G ++G +F+ Y + D +
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFV--YGKDIKTDLHT 1097
Query: 1373 L-KCMGYCPQINPLWPDTTLQEHFEIYGAVK--GMSASDMKEVISRITHALDLKEHLQKT 1429
+ K MG C Q + L+ T +EH +YG++K + + E + R L H K
Sbjct: 1098 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1157
Query: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNR-KRAAIL 1488
V L G+KRKL +++++G ++ +LDEPSTG+DP +++ +W I KN+ R IL
Sbjct: 1158 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1214
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVD---- 1544
+TH+++EAE + DR+A + G LRC G+ +LK FG GY L + K NL +
Sbjct: 1215 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK-SPNLNANAVCD 1273
Query: 1545 --RLQREIQYIFPNASRQESFSSILAYKIP--KEDVQSLSQSFFK-LEEAKHAFAIEEYS 1599
+ IQ P A +E L Y +P V S + L+ I Y
Sbjct: 1274 TMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYG 1333
Query: 1600 FSQATLEQVFVELTKEQEE 1618
S T+E+VF+ LTKE ++
Sbjct: 1334 ISDTTVEEVFLNLTKESQK 1352
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 290 bits (743), Expect = 6e-78
Identities = 209/784 (26%), Positives = 385/784 (49%), Gaps = 64/784 (8%)
Query: 167 QYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLV 226
Q + F LQ SI+ AII+L+T + + +A+ T + I L+
Sbjct: 1015 QIYGRAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLM 1074
Query: 227 IAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIAT 286
+A+ F +V EK+ ++ E++K+MG++ + + +W++ + + +++ +I
Sbjct: 1075 VAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILK 1134
Query: 287 ASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMII 346
+ P+++ ++FL F Y S + + +++ F + ++ + + F ++++
Sbjct: 1135 FGNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194
Query: 347 LIESFPKSLVWLFSPFCHCT-FVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITII---- 401
+E+ ++ +F T F + E+ G + N+ P T
Sbjct: 1195 TVENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLC 1254
Query: 402 -MLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSK---------SKRN---YE 448
++ +S Y L+A Y+ V PG +G+ + + PSYW + K N +
Sbjct: 1255 CLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFT 1314
Query: 449 ELSEGNVNGNIS----FSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDI 504
+ N N + S FS IEP + + + G+ K Y K A+ NL+ +
Sbjct: 1315 NIMMQNTNPSASPEYMFSSNIEPEPKDLT--VGVALHGVTKIYGSK----VAVDNLNLNF 1368
Query: 505 YEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQL 564
YEG IT+LLG +G GK+T +++L GL S G +YG + ++ RK +G+C Q
Sbjct: 1369 YEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKT--DLHTVRKNMGVCMQH 1426
Query: 565 DIHFDVLTVEENLSILASIKGIP---ANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKR 621
D+ F LT +E+L + SIK +P + +EV++ L D + + + + LSGG KR
Sbjct: 1427 DVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKR 1485
Query: 622 KLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILAD 681
KLS+ IA++G ++++LDEP+ G+DPCSR +W+++ K R + STH +DEA++L+D
Sbjct: 1486 KLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSD 1545
Query: 682 RKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK--------YCATESLSSLVKQHIPG 733
R A + QG L+C GS +LK +G GY L++ K C T +++++++ H+P
Sbjct: 1546 RIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPE 1605
Query: 734 ATLLQQNDQQLVYSLP---FKDMDKFSGLFSALDS-HSNLGVISYGVSMTTLEDVFLKLE 789
A L + +LVY LP K + L ALD+ +L + YG+S TT+E+VFL L
Sbjct: 1606 AYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLT 1665
Query: 790 VEAEIDQA-DYSVFTQQ------------PLEEEMDSKSFDEMEQSLLILSETKAALVST 836
E++ + A TQ+ P + + S +F + + +L T+ +
Sbjct: 1666 KESQKNSAMSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKIL----TRGERLDG 1721
Query: 837 MSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLV 896
L +++ I F +R K + + ++L ++F T + + + +S N+ I++
Sbjct: 1722 FGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNS-SNSYPEIQIS 1780
Query: 897 PDLY 900
P LY
Sbjct: 1781 PSLY 1784
Score = 246 bits (627), Expect = 2e-64
Identities = 196/687 (28%), Positives = 323/687 (47%), Gaps = 88/687 (12%)
Query: 978 YSLPILVNIISNYYLYHLNVTET------IQIWSTPF----FQEITDIVFKIELYFQAAL 1027
+SLP +N ++N+ L +N+++ I ++S P+ QE I I++ ++
Sbjct: 1935 HSLPAYLNSLNNFLL-RVNMSKYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVALSI 1993
Query: 1028 L-GIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLG 1086
L G VT F H+ KA +SG+ + YW+ + D+ + + + +G
Sbjct: 1994 LMGYSVTTAS--FVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIG 2051
Query: 1087 SLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAAL 1146
+ F FY+ L V L+ +LF Y A+F++ +L + ++ +
Sbjct: 2052 IIAIFKLPA-FYSENNLGAVSLLL------LLFGY-ATFSWMYLL------AGLFHETGM 2097
Query: 1147 ACIAITEITFFMGYTIATILHYAFCI-------------------IIPIYPLL------- 1180
A I + F G L + + I I+P
Sbjct: 2098 AFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLI 2157
Query: 1181 -----GCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGR 1235
++ F+K N + VA++S F L+ + +
Sbjct: 2158 ELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTM----FFSLRLLINESLIK 2213
Query: 1236 SIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNL 1295
+R FFR ++ + DEDEDV+AERL+V+ E + + L
Sbjct: 2214 KLRL--FFRKFNSSHVRETI-------DEDEDVRAERLRVES-----GAAEFDLVQLYCL 2259
Query: 1296 HKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSG 1355
K Y L+ +K+ +A IS + GE GLLG NGAGK+TI +L GDI P+SG
Sbjct: 2260 TKTYQ-----LIHKKI--IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSG 2312
Query: 1356 QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISR 1415
+ + + + D +GYCPQ + L T++EH Y V G+ D+KE + +
Sbjct: 2313 NILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHK 2372
Query: 1416 ITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAI 1475
+ L L + G KRKL AL+++G P I LLDEPS+GMDPK+K+H+W+ I
Sbjct: 2373 LLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKII 2432
Query: 1476 RTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK 1535
+N K + ILT+H MEE EA+C R+AIMV+G+ +CIG++QH+KS+FG+G+ +++ LK
Sbjct: 2433 SEEVQN-KCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLK 2491
Query: 1536 DWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAI 1595
+ + ++ L + +Q FP ++ S+L Y +P ++ F LE K A I
Sbjct: 2492 N--NKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNI 2548
Query: 1596 EEYSFSQATLEQVFVELTKEQEEEDNS 1622
+ SQ TLE+VF+ K+Q+ + +
Sbjct: 2549 TNFLVSQTTLEEVFINFAKDQKSYETA 2575
Score = 202 bits (514), Expect = 2e-51
Identities = 154/594 (25%), Positives = 287/594 (48%), Gaps = 45/594 (7%)
Query: 220 VILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSL 279
++ + +++ +S ++V E + K K+ I G+ T +W++ +Y + +L+ +
Sbjct: 1988 LVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVT-NFIYDMVFYLVPV 2046
Query: 280 LMAVIATASLLFP----QSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVT 335
++ A P +++ + LL L+G ++ + +L LF ++ I V
Sbjct: 2047 AFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVN 2106
Query: 336 VAFGF---IGLMII--------------LIESFPKSLVWLFSPFCHCTFVIGIAQVMHLE 378
+ FG + L ++ LI K + +F FC +I ++Q +
Sbjct: 2107 LFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVL 2166
Query: 379 DFNE--GASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLK 436
DF + G + N T L + L + L + +++ + +++ L+F K
Sbjct: 2167 DFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESL-----IKKLRLFFRK 2221
Query: 437 PSYWSKSKRNYEELSEGNVNGNISFSEI-IEPVSSEFVGKEAIRISGIQKTYRKKGENVE 495
S E + E ++ + +E ++EF + +++ + KTY+ + +
Sbjct: 2222 ----FNSSHVRETIDEDE---DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHKKII 2271
Query: 496 ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEAR 555
A+ N+S I G+ LLG +G GK+T+ +L G PS G I ++ + +
Sbjct: 2272 AVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR-NKTGSLGHVDSHS 2330
Query: 556 KMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKL 615
++G CPQ D D++TVEE+L A + GIP +I + V K+L L + KD
Sbjct: 2331 SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMC 2390
Query: 616 SGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST-HFMD 674
S G KRKLS +A++G P ILLLDEP++GMDP S+ +W ++ N+ +V T H M+
Sbjct: 2391 SYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHSME 2450
Query: 675 EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT-ESLSSLVKQHIPG 733
E + L R A++ G +C+GS +KS++G G+ + +++ T E+L+ ++ H P
Sbjct: 2451 ECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPK 2510
Query: 734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN-LGVISYGVSMTTLEDVFL 786
L Q+ L Y +P + +F L+++ L + ++ VS TTLE+VF+
Sbjct: 2511 TYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFI 2563
Score = 160 bits (404), Expect = 1e-38
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 19/319 (5%)
Query: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372
KVA ++ +G I LLGPNGAGK+T I++L G ++G +F+ Y + D +
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFV--YGKDIKTDLHT 1415
Query: 1373 L-KCMGYCPQINPLWPDTTLQEHFEIYGAVK--GMSASDMKEVISRITHALDLKEHLQKT 1429
+ K MG C Q + L+ T +EH +YG++K + + E + R L H K
Sbjct: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1475
Query: 1430 VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNR-KRAAIL 1488
V L G+KRKL +++++G ++ +LDEPSTG+DP +++ +W I KN+ R IL
Sbjct: 1476 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1532
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVD---- 1544
+TH+++EAE + DR+A + G LRC G+ +LK FG GY L + K NL +
Sbjct: 1533 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK-SPNLNANAVCD 1591
Query: 1545 --RLQREIQYIFPNASRQESFSSILAYKIP--KEDVQSLSQSFFK-LEEAKHAFAIEEYS 1599
+ IQ P A +E L Y +P V S + L+ I Y
Sbjct: 1592 TMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYG 1651
Query: 1600 FSQATLEQVFVELTKEQEE 1618
S T+E+VF+ LTKE ++
Sbjct: 1652 ISDTTVEEVFLNLTKESQK 1670
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 273 bits (699), Expect = 8e-73
Identities = 214/797 (26%), Positives = 377/797 (47%), Gaps = 104/797 (13%)
Query: 84 VTNITSSIMQKVSTDHLPDVIIT--EEYTNEKEMLTSSLSKPSN---FVGVVFKDS---- 134
+ NIT ++ V+ +L +++ E Y +E ++ +LS + GVVF D
Sbjct: 502 IFNITDRTLRLVN-QYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWT 560
Query: 135 ------MSYELRFFPDMIP----VSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAI 184
+ Y++R D++ + Y DS + W GF LQ ++ I
Sbjct: 561 SSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGI 619
Query: 185 ----IQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
+Q + V ++ + + ++ FP I++V+A+ I
Sbjct: 620 TRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFP-----IFMVLAWIYSVSMTVKSI 674
Query: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
V EKE ++KE LK G+ + W +W L S++ + L+ + + S ++F
Sbjct: 675 VLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILF 734
Query: 301 LLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLV 356
L + +++ +L+ F K+ G++ F + + + + K V
Sbjct: 735 LFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAV 794
Query: 357 WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLTLNSIFYV 411
L SP F G ++ E+ G +SN+ P + ++++ M+ L++ Y
Sbjct: 795 SLLSPVA---FGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYG 851
Query: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYW-------SKSKRNYEELSEGNVNGNISFSEI 464
LLA YLDQV PG++G + L+ SYW ++ +R E+ + E
Sbjct: 852 LLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP--LTEETEDPEH 909
Query: 465 IEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGT 518
E + F +E + + + K + G A+ L+ YE QITA LGH+G
Sbjct: 910 PEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGR--PAVDRLNITFYENQITAFLGHNGA 967
Query: 519 GKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEA-RKMIGICPQLDIHFDVLTVEENL 577
GK+T ++IL GL PP+ G + G +I+ +A R+ +G+CPQ +I F LTV E++
Sbjct: 968 GKTTTLSILTGLLPPTSGTVLVGGR---DIETSLDAVRQSLGMCPQHNILFHHLTVAEHM 1024
Query: 578 SILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILL 637
A +KG E++ +L D + ++ +A+ LSGG +RKLS+ IA +G+ K+++
Sbjct: 1025 LFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVI 1084
Query: 638 LDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSS 697
LDEPT+G+DP SR +W+LL ++ R + STH MDEAD+L DR A+I+QG L C G+
Sbjct: 1085 LDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTP 1144
Query: 698 MFLKSKWGIGYRLSM-------------------------------YIDKYCATE----- 721
+FLK+ +G G L++ ++D +
Sbjct: 1145 LFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGD 1204
Query: 722 --SLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMD--KFSGLFSAL-DSHSNLGVISYGV 776
L +V H+P A L++ Q+L++ LP K+ ++ LF L ++ ++LG+ S+G+
Sbjct: 1205 VNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGI 1264
Query: 777 SMTTLEDVFLKLEVEAE 793
S T LE++FLK+ +++
Sbjct: 1265 SDTPLEEIFLKVTEDSD 1281
Score = 215 bits (548), Expect = 2e-55
Identities = 176/592 (29%), Positives = 291/592 (49%), Gaps = 82/592 (13%)
Query: 1057 LSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSV 1116
+SG+ P+ YW+ + DI + + L++G + F Y A+V L+ Y +V
Sbjct: 1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAV 1774
Query: 1117 ILFTYIASFTFKKILNTKEFWSFIYSVAALAC------IAITEITFFMGY--TIATILHY 1168
I Y ASF F + +T + AL+C I + ITF + T+L +
Sbjct: 1775 IPMMYPASFLFD-VPST--------AYVALSCANLFIGINSSAITFILELFENNRTLLRF 1825
Query: 1169 AFCI--IIPIYPLLGCLISFIKISWKNVRKNV-------DTYNP--WDRLSVAVISPYLQ 1217
+ ++ ++P I ++ +V + NP WD + + + ++
Sbjct: 1826 NAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVE 1885
Query: 1218 CVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNE--DEDEDVKAERLKV 1275
V++ FLL +++ FF + + + EP DED+DV ER ++
Sbjct: 1886 GVVY-FLLTLLVQRH---------FFLS-------QWIAEPTKEPIVDEDDDVAEERQRI 1928
Query: 1276 KELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-------ATKYISFCVKKGEI 1328
+ G +K D L ++ K+ A + V+ GE
Sbjct: 1929 --ITG-------------------GNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGEC 1967
Query: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPD 1388
GLLG NGAGK+T +L GD TSG + S T+ + MGYCPQ + +
Sbjct: 1968 FGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQN-MGYCPQFDAIDEL 2026
Query: 1389 TTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSML 1448
T +EH +Y ++G+ A ++++V + +L L + G KRKL A++++
Sbjct: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
Query: 1449 GNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVS 1508
G P + LLDEP+TGMDP+A++ +W I + + RA +LT+H MEE EA+C R+AIMV
Sbjct: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVVLTSHSMEECEALCTRLAIMVK 2145
Query: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--EVDRLQREIQYIFPNASRQESFSSI 1566
G RC+GT+QHLKSKFG GY + +K+K ++L +++ +++ Q FP + ++E ++
Sbjct: 2146 GAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNM 2205
Query: 1567 LAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
L +++ SL++ F L K + IEEYS +Q TL+QVFV K+Q E
Sbjct: 2206 LQFQVSS---SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTE 2254
Score = 156 bits (395), Expect = 1e-37
Identities = 148/608 (24%), Positives = 275/608 (45%), Gaps = 63/608 (10%)
Query: 210 VVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---W 266
+ + T V+ I ++ + S ++++ E+ K K I G+ T +W++ W
Sbjct: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
Query: 267 -VLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFK--K 323
++ Y+ L+ + + P++ ++ LL LYG + + + LF
Sbjct: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLL-LYGWAVIPMMYPASFLFDVPS 1789
Query: 324 SKHVGI--VEFFVTVAFGFIGLMIILIES---------FPKSLVWLFSPFCHCTFVIGIA 372
+ +V + F+ + I ++ L E+ + L+ +F FC +I +A
Sbjct: 1790 TAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLA 1849
Query: 373 QVMHLED----FNEGASFSNLTAGPYPLII---TIIMLTLNSIFYVLLAVYLDQVIPGEF 425
+ D F E S A P+ + + + + + Y LL + + +
Sbjct: 1850 LSQAVTDVYARFGEEHS-----ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRH----- 1899
Query: 426 GLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQK 485
+FL S W E E V+ + +E + + + + +R+ + K
Sbjct: 1900 -------FFL--SQWIA-----EPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTK 1945
Query: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
Y G + A+ L + G+ LLG +G GK+T +L G + G A++ G +
Sbjct: 1946 IY--PGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSI 2003
Query: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQ 605
+ + E + +G CPQ D ++LT E+L + A ++G+PA I + + L +
Sbjct: 2004 --LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLT 2061
Query: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANR 664
D A SGG KRKLS IA++G P ++LLDEPT GMDP +R ++WN ++ + R
Sbjct: 2062 VYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGR 2121
Query: 665 VTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-----DKYCA 719
V ++H M+E + L R A++ +G +C+G+ LKSK+G GY ++M I D
Sbjct: 2122 AVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPD 2181
Query: 720 TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSM 778
+ + + PG+ +++ L + + + + +F L SH +L + Y V+
Sbjct: 2182 LNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLAR---IFQLLLSHKDSLLIEEYSVTQ 2238
Query: 779 TTLEDVFL 786
TTL+ VF+
Sbjct: 2239 TTLDQVFV 2246
Score = 145 bits (365), Expect = 4e-34
Identities = 100/368 (27%), Positives = 180/368 (48%), Gaps = 51/368 (13%)
Query: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
P + V NL K ++ + A ++ + +I LG NGAGK+T ++IL
Sbjct: 927 PGVCVKNLVKIFEP---------CGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILT 977
Query: 1348 GDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSAS 1407
G + PTSG V +G ETS D + +G CPQ N L+ T+ EH Y +KG S
Sbjct: 978 GLLPPTSGTVLVGGRDIETSLDAVR-QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQE 1036
Query: 1408 DMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKA 1467
+ + + + L + + L G++RKL A++ +G+ ++ +LDEP++G+DP +
Sbjct: 1037 EAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYS 1096
Query: 1468 KQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
++ +W + K R R I++TH+M+EA+ + DR+AI+ G+L C GT LK+ FG
Sbjct: 1097 RRSIWDLL---LKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGT 1153
Query: 1527 GYFLEI--KLKD-------------------------WIENL--------EVDRLQREIQ 1551
G +L + K+K+ +++L +V+ L +
Sbjct: 1154 GLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVL 1213
Query: 1552 YIFPNASRQESFSSILAYKIPKEDV--QSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVF 1609
+ P A E L + +P ++ ++ + F +LEE + + S LE++F
Sbjct: 1214 HHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIF 1273
Query: 1610 VELTKEQE 1617
+++T++ +
Sbjct: 1274 LKVTEDSD 1281
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 270 bits (689), Expect = 1e-71
Identities = 187/611 (30%), Positives = 303/611 (49%), Gaps = 69/611 (11%)
Query: 240 IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299
+V EKE ++++ ++ MGL WL W L L + L+ ++ + P S V+
Sbjct: 569 VVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVV 628
Query: 300 FLLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSL 355
FL + +++V + +L+ F ++ G+ F + + + + + +
Sbjct: 629 FLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVA 688
Query: 356 VWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNL----TAGPYPLIITIIMLTLNSIFYV 411
L SP F G + LE+ EGA + N+ TA + L +L L++ Y
Sbjct: 689 ASLLSPVA---FGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYG 745
Query: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSE 471
L YL+ V PG++G+ + + SYW + S + P+ +
Sbjct: 746 LATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPK------------SPAPCPTPLDPK 793
Query: 472 FVGKEA-------IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLM 524
+ +EA + + ++K + G ALR LS D Y+G ITA LGH+G GK+T +
Sbjct: 794 VLVEEAPPGLSPGVSVRSLEKRF--PGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTL 851
Query: 525 NILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK 584
+IL GL PPS G A I GH V M R +G+CPQ ++ FD+LTV+E++ +K
Sbjct: 852 SILSGLFPPSGGSAFILGHDVRS--SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLK 909
Query: 585 GIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAG 644
G+ A + E ++L D+ + + + Q + LSGG +RKLS+ IA +G ++++LDEPTAG
Sbjct: 910 GLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAG 969
Query: 645 MDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKW 704
+DP SR +W LL + R + STH +DEA++L DR AV++ G L C GS +FL+
Sbjct: 970 VDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHL 1029
Query: 705 GIGYRLSMY-------------------ID-----------KYCATESLSSLVKQHIPGA 734
G GY L++ +D T L +LV+ +PGA
Sbjct: 1030 GSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGA 1089
Query: 735 TLLQQNDQQLVYSLPFKDM--DKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKL--E 789
L+++ +LV LP+ F+ LF LD+ + L + YG+S T+LE++FLK+ E
Sbjct: 1090 RLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
Query: 790 VEAEIDQADYS 800
A+ D D S
Sbjct: 1150 CAADTDMEDGS 1160
Score = 200 bits (509), Expect = 8e-51
Identities = 166/633 (26%), Positives = 283/633 (44%), Gaps = 116/633 (18%)
Query: 1035 MPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYG 1094
+P F + E +A + GL P+ YW+G + D+ + + +++ LAF
Sbjct: 1549 VPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQR 1608
Query: 1095 LYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI 1154
Y A++ L+ Y S+ Y ASF F SV + A + +T I
Sbjct: 1609 AYVAPANLPALLLLLLLYGWSITPLMYPASFFF--------------SVPSTAYVVLTCI 1654
Query: 1155 TFFMGYT------------------IATILHYAFCIIIPIYPLLGCLISFIK-------- 1188
F+G ++ IL F +I P + L LI ++
Sbjct: 1655 NLFIGINGSMATFVLELFSDQKLQEVSRILKQVF-LIFPHFCLGRGLIDMVRNQAMADAF 1713
Query: 1189 -----------ISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSI 1237
+ W+ V KN+ L++ + P +L+ LLQ+
Sbjct: 1714 ERLGDRQFQSPLRWEVVGKNL--------LAMVIQGPLF--LLFTLLLQH---------- 1753
Query: 1238 RKDPFFRNLSTKSKNRKLPEP-----PDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMV 1292
+++ LP+P P +EDEDV ER +V Q + +++
Sbjct: 1754 -------------RSQLLPQPRVRSLPLLGEEDEDVARERERV-----VQGATQGDVLVL 1795
Query: 1293 SNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP 1352
NL K Y R + A + + GE GLLG NGAGK++ ++ GD
Sbjct: 1796 RNLTKVY---------RGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLA 1846
Query: 1353 TSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV 1412
+ G+ L +S L MGYCPQ + ++ T +EH E+ ++G+ + + +
Sbjct: 1847 SRGEAVLAGHSVAREPSAAHLS-MGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT 1905
Query: 1413 ISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMW 1472
L L + + G KRKL AL+++G+P + LDEP+TGMDP A++ +W
Sbjct: 1906 AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLW 1965
Query: 1473 RAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEI 1532
++ A R+ +LT+H MEE EA+C R+AIMV+G+ RC+G+ QHLK +F G+ L +
Sbjct: 1966 NSL-LAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL 2024
Query: 1533 KLKDWIENLEVDRLQREIQYI---FPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEA 1589
+ + R Q ++ FP A +E+ L +++P +L++ F +L
Sbjct: 2025 R-------VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVH 2077
Query: 1590 KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
+E++S SQ LE+VF+ +K+Q +++++
Sbjct: 2078 GAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDT 2110
Score = 170 bits (431), Expect = 9e-42
Identities = 156/598 (26%), Positives = 259/598 (43%), Gaps = 71/598 (11%)
Query: 221 ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVL----------LY 270
I + ++F P + L + + E+ + K + GL T +WL L
Sbjct: 1540 ICVVFAMSFVPASFTLVL--IEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACI 1597
Query: 271 TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIV 330
LIFL A +A A+L + LL LYG S + F +V
Sbjct: 1598 VVLIFLAFQQRAYVAPANLP-------ALLLLLLLYGWSITPLMYPASFFFSVPSTAYVV 1650
Query: 331 EFFVTVAFGFIGLMI-ILIESFP-----------KSLVWLFSPFCHCTFVIGIAQVMHLE 378
+ + G G M ++E F K + +F FC +I + + +
Sbjct: 1651 LTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA 1710
Query: 379 DFNEGASFSNLTAGPYPL--------IITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRS 430
D E + PL ++ +++ + + LL + Q++P R
Sbjct: 1711 DAFERLGDRQFQS---PLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQP---RVR 1764
Query: 431 SLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKK 490
SL L + R E + +G G++ + + + K YR
Sbjct: 1765 SLPLLGEEDEDVA-RERERVVQGATQGDV------------------LVLRNLTKVYR-- 1803
Query: 491 GENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDE 550
G+ + A+ L I G+ LLG +G GK++ ++ G S G A + GH V+ E
Sbjct: 1804 GQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR--E 1861
Query: 551 MFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610
A +G CPQ D F++LT E+L +LA ++G+P + Q L L + D
Sbjct: 1862 PSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADR 1921
Query: 611 QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANRVTVFS 669
A SGG KRKL+ +A++G+P ++ LDEPT GMDP +R +WN LL + R + +
Sbjct: 1922 PAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLT 1981
Query: 670 THFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQ 729
+H M+E + L R A++ G +C+GS LK ++ G+ L++ + ++ ++ V
Sbjct: 1982 SHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPA-ARSQPAAAFVAA 2040
Query: 730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFL 786
PGA L + + +L + LP + +F L H + GV + VS T LE+VFL
Sbjct: 2041 EFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFL 2098
Score = 140 bits (353), Expect = 1e-32
Identities = 150/614 (24%), Positives = 260/614 (42%), Gaps = 76/614 (12%)
Query: 1055 LKLSGLLPSAYWIGQAVVDIPLFFI-----ILILMLGSLLAF-HYGLYFYTVKFLAVVFC 1108
++ GL + W+G + + F + +L+L LG +L + H G+ F FLA F
Sbjct: 581 MRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL---FLAA-FA 636
Query: 1109 LIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHY 1168
+ S +L + + ++S + + C+A + G A++L
Sbjct: 637 VATVTQSFLLSAFFSRANLAAACGGLAYFSLY--LPYVLCVAWRDRLPAGGRVAASLLS- 693
Query: 1169 AFCIIIPIYPLLGC-LISFIKISWKNVR-KNVDTYNPWDRLSVAVISPYL--QCVLWIFL 1224
P+ GC ++ ++ + + NV T D S+A +S L L+
Sbjct: 694 ------PVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLA 747
Query: 1225 LQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCC 1284
Y E G+ +P+ N + P PP + ++ V+E
Sbjct: 748 TWYLEAVCPGQYGIPEPW--NFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGL-- 803
Query: 1285 EEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIIN 1344
P + V +L K + + A + +S +G I LG NGAGK+T ++
Sbjct: 804 --SPGVSVRSLEKRFPGSP---------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852
Query: 1345 ILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGM 1404
IL G P+ G F+ + +S +G CPQ N L+ T+ EH YG +KG+
Sbjct: 853 ILSGLFPPSGGSAFILGHDVRSSMAAIRPH-LGVCPQYNVLFDMLTVDEHVWFYGRLKGL 911
Query: 1405 SASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464
SA+ + R+ + L + L G++RKL A++ +G Q+ +LDEP+ G+D
Sbjct: 912 SAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVD 971
Query: 1465 PKAKQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSK 1523
P +++ +W + K R+ R IL+TH+++EAE + DRVA++ G+L C G+ L+
Sbjct: 972 PASRRGIWELL---LKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRH 1028
Query: 1524 FGKGYFLEI----------KLKDWIENLEVDRLQRE-----------------IQYIFPN 1556
G GY+L + + D VD Q + +Q+ P
Sbjct: 1029 LGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPG 1088
Query: 1557 ASRQESFSSILAYKIPKEDVQ--SLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTK 1614
A E L +P S + F +L+ + Y S +LE++F+++ +
Sbjct: 1089 ARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVE 1148
Query: 1615 E----QEEEDNSCG 1624
E + ED SCG
Sbjct: 1149 ECAADTDMEDGSCG 1162
Score = 37.7 bits (86), Expect = 0.092
Identities = 17/50 (34%), Positives = 27/50 (54%)
Query: 11 WRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEE 60
W Q LL KN++ + R + E+L+PLF F L+ + HP ++ E
Sbjct: 4 WTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHE 53
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 117 bits (293), Expect = 9e-26
Identities = 55/146 (37%), Positives = 92/146 (63%), Gaps = 1/146 (0%)
Query: 1390 TLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLG 1449
T QE +Y + G+S + +++ ++L+L+ H + + G KR+L A++++G
Sbjct: 2 TAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALMG 61
Query: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSG 1509
+ LDEPSTGMDP A++ +W + T + +A ++T+H MEE +A+C +AIMV G
Sbjct: 62 RSSVIFLDEPSTGMDPVARRLLWNMV-TKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1510 QLRCIGTVQHLKSKFGKGYFLEIKLK 1535
+ C+G+ QHLKSKFG Y L++K+K
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK 146
Score = 98.6 bits (244), Expect = 4e-20
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 1/164 (0%)
Query: 571 LTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL 630
+T +E + + A I G+ I V K L L++++ S G KR+LS IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GNPKILLLDEPTAGMDPCSRHIVWNLL-KYRKANRVTVFSTHFMDEADILADRKAVISQG 689
G ++ LDEP+ GMDP +R ++WN++ K R++ + V ++H M+E D L A++ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 MLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPG 733
C+GS LKSK+G Y L + + E V PG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 117 bits (293), Expect = 9e-26
Identities = 55/146 (37%), Positives = 92/146 (63%), Gaps = 1/146 (0%)
Query: 1390 TLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLG 1449
T QE +Y + G+S + +++ ++L+L+ H + + G KR+L A++++G
Sbjct: 2 TAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALMG 61
Query: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSG 1509
+ LDEPSTGMDP A++ +W + T + +A ++T+H MEE +A+C +AIMV G
Sbjct: 62 RSSVIFLDEPSTGMDPVARRLLWNMV-TKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1510 QLRCIGTVQHLKSKFGKGYFLEIKLK 1535
+ C+G+ QHLKSKFG Y L++K+K
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK 146
Score = 98.6 bits (244), Expect = 4e-20
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 1/164 (0%)
Query: 571 LTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL 630
+T +E + + A I G+ I V K L L++++ S G KR+LS IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GNPKILLLDEPTAGMDPCSRHIVWNLL-KYRKANRVTVFSTHFMDEADILADRKAVISQG 689
G ++ LDEP+ GMDP +R ++WN++ K R++ + V ++H M+E D L A++ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 MLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPG 733
C+GS LKSK+G Y L + + E V PG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 117 bits (293), Expect = 9e-26
Identities = 55/146 (37%), Positives = 92/146 (63%), Gaps = 1/146 (0%)
Query: 1390 TLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLG 1449
T QE +Y + G+S + +++ ++L+L+ H + + G KR+L A++++G
Sbjct: 2 TAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALMG 61
Query: 1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSG 1509
+ LDEPSTGMDP A++ +W + T + +A ++T+H MEE +A+C +AIMV G
Sbjct: 62 RSSVIFLDEPSTGMDPVARRLLWNMV-TKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1510 QLRCIGTVQHLKSKFGKGYFLEIKLK 1535
+ C+G+ QHLKSKFG Y L++K+K
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVK 146
Score = 98.6 bits (244), Expect = 4e-20
Identities = 55/164 (33%), Positives = 87/164 (53%), Gaps = 1/164 (0%)
Query: 571 LTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL 630
+T +E + + A I G+ I V K L L++++ S G KR+LS IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 631 GNPKILLLDEPTAGMDPCSRHIVWNLL-KYRKANRVTVFSTHFMDEADILADRKAVISQG 689
G ++ LDEP+ GMDP +R ++WN++ K R++ + V ++H M+E D L A++ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 690 MLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQHIPG 733
C+GS LKSK+G Y L + + E V PG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFPG 164
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 94.7 bits (234), Expect = 6e-19
Identities = 75/265 (28%), Positives = 127/265 (47%), Gaps = 37/265 (13%)
Query: 436 KPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVE 495
KPS S SK ++ N+ GN+ F + +Y + E V+
Sbjct: 372 KPSIDSYSKSGHKP---DNIKGNLEFRNV-------------------HFSYPSRKE-VK 408
Query: 496 ALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEAR 555
L+ L+ + GQ AL+G+SG GKST + ++ L P++G S+ G + I+ F R
Sbjct: 409 ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRF-LR 467
Query: 556 KMIGICPQLDIHFDVLTVE------ENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKD 609
++IG+ Q + F E EN+++ K + N + K+ D T+
Sbjct: 468 EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFD--TLVG 525
Query: 610 NQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFS 669
+ +LSGGQK+++++ A++ NPKILLLDE T+ +D S +V L + R T+
Sbjct: 526 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVI 585
Query: 670 THFMD---EADILA--DRKAVISQG 689
H + AD++A D ++ +G
Sbjct: 586 AHRLSTVRNADVIAGFDDGVIVEKG 610
Score = 81.3 bits (199), Expect = 7e-15
Identities = 65/270 (24%), Positives = 124/270 (45%), Gaps = 30/270 (11%)
Query: 448 EELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEG 507
E L + GN++F E++ + ++ L+ LS ++ +G
Sbjct: 1024 EGLMPNTLEGNVTFGEVVFNYPTR--------------------PDIPVLQGLSLEVKKG 1063
Query: 508 QITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIH 567
Q AL+G SG GKST++ +L P G + G + ++ + R +GI Q I
Sbjct: 1064 QTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW-LRAHLGIVSQEPIL 1122
Query: 568 FDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKK-------LSGGQK 620
FD ++ EN++ + + + I++ ++ + ++++ + + K LSGGQK
Sbjct: 1123 FDC-SIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQK 1181
Query: 621 RKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILA 680
+++++ A++ P ILLLDE T+ +D S +V L + R + H + A
Sbjct: 1182 QRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NA 1240
Query: 681 DRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
D V G +K G+ L ++ GI + +
Sbjct: 1241 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 58.9 bits (141), Expect = 4e-08
Identities = 53/211 (25%), Positives = 97/211 (45%), Gaps = 24/211 (11%)
Query: 1287 KPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINIL 1346
K ++ N+H Y +K+ + K ++ V+ G+ + L+G +G GKST + ++
Sbjct: 389 KGNLEFRNVHFSYPSRKEVKI--------LKGLNLKVQSGQTVALVGNSGCGKSTTVQLM 440
Query: 1347 VGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHF----------E 1396
+PT G V + T + +G Q P+ TT+ E+ E
Sbjct: 441 QRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQ-EPVLFATTIAENIRYGRENVTMDE 499
Query: 1397 IYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLL 1456
I AVK +A D I ++ H D + + +L G K+++ A +++ NP+I LL
Sbjct: 500 IEKAVKEANAYDF---IMKLPHKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLL 554
Query: 1457 DEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
DE ++ +D +++ + A+ A K R I
Sbjct: 555 DEATSALDTESEAVVQVALDKARKGRTTIVI 585
Score = 58.5 bits (140), Expect = 5e-08
Identities = 52/217 (23%), Positives = 102/217 (47%), Gaps = 17/217 (7%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+S VKKG+ L L+G +G GKST++ +L +P +G+V L + +G
Sbjct: 1056 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGI 1115
Query: 1379 CPQINPLWPDTTLQEHFEIYG----------AVKGMSASDMKEVISRITHALDLKEHLQK 1428
Q P+ D ++ E+ YG V+ +++ I + + K +
Sbjct: 1116 VSQ-EPILFDCSIAENI-AYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKG 1173
Query: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
T +L G K+++ A +++ P I LLDE ++ +D ++++ + A+ A R I+
Sbjct: 1174 T--QLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA--REGRTCIV 1229
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFG 1525
H + + D + + +G+++ GT Q L ++ G
Sbjct: 1230 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1265
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 90.5 bits (223), Expect = 1e-17
Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 18/247 (7%)
Query: 477 AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDG 536
A+ + Y + E V ++ S I G +TAL+G SG+GKST++++L L P+ G
Sbjct: 491 ALEFKNVHFAYPARPE-VPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASG 549
Query: 537 FASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
S+ GH + +++ ++ R IG Q I F ++ EN++ A P++ +E+Q
Sbjct: 550 TISLDGHDIRQLNPVW-LRSKIGTVSQEPILFS-CSIAENIAYGAD---DPSSVTAEEIQ 604
Query: 597 KVL-----------LDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGM 645
+V T+ + LSGGQK+++++ A+L NPKILLLDE T+ +
Sbjct: 605 RVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSAL 664
Query: 646 DPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWG 705
D + ++V L R + H + A+ AV+ QG + G L SK
Sbjct: 665 DAENEYLVQEALDRLMDGRTVLVIAHRLSTIK-NANMVAVLDQGKITEYGKHEELLSKPN 723
Query: 706 IGYRLSM 712
YR M
Sbjct: 724 GIYRKLM 730
Score = 55.5 bits (132), Expect = 4e-07
Identities = 49/213 (23%), Positives = 96/213 (45%), Gaps = 14/213 (6%)
Query: 1320 SFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYC 1379
S + G + L+GP+G+GKST++++L+ +P SG + L + +G
Sbjct: 514 SLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTV 573
Query: 1380 PQINPLWPDTTLQEHFEIYGA-----VKGMSASDMKEVISRITHALDLKEHLQKTVKK-- 1432
Q P+ ++ E+ YGA V + EV + + + + V +
Sbjct: 574 SQ-EPILFSCSIAENI-AYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKG 631
Query: 1433 --LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTT 1490
L G K+++ A ++L NP+I LLDE ++ +D + + + A+ R ++
Sbjct: 632 VLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDG--RTVLVIA 689
Query: 1491 HYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSK 1523
H + + + VA++ G++ G + L SK
Sbjct: 690 HRLSTIKN-ANMVAVLDQGKITEYGKHEELLSK 721
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 90.5 bits (223), Expect = 1e-17
Identities = 66/227 (29%), Positives = 112/227 (49%), Gaps = 16/227 (7%)
Query: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMF 552
NV+ L+ L+ + GQ AL+G SG GKST + ++ L P +G +I G + + +
Sbjct: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY 467
Query: 553 EARKMIGICPQLDIHFDVLTVEE------NLSILASIKGIPANNIIQEVQKVLLDLDMQT 606
R++IG+ Q + F E N+++ K + N + + K+ D T
Sbjct: 468 -LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD--T 524
Query: 607 IKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVT 666
+ + +LSGGQK+++++ A++ NPKILLLDE T+ +D S V L + R T
Sbjct: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 667 VFSTHFMD---EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
+ H + AD++A G++ GS L K G+ ++L
Sbjct: 585 IVIAHRLSTVRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 80.1 bits (196), Expect = 2e-14
Identities = 69/277 (24%), Positives = 125/277 (45%), Gaps = 37/277 (13%)
Query: 448 EELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEG 507
E L GNI+F+E++ + NV L+ LS ++ +G
Sbjct: 1023 EGLKPDKFEGNITFNEVVFNYPTR--------------------ANVPVLQGLSLEVKKG 1062
Query: 508 QITALLGHSGTGKSTLMNILCGLCPP-------SDGFASIYGHRVSEIDEMFEARKMIGI 560
Q AL+G SG GKST++ +L P GF + G +++ + R +GI
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW-LRAQLGI 1121
Query: 561 CPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKD-------NQAK 613
Q I FD ++ EN++ + + + + I+ + + ++T+ ++
Sbjct: 1122 VSQEPILFDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1180
Query: 614 KLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFM 673
+LSGGQK+++++ A++ P+ILLLDE T+ +D S +V L + R + H +
Sbjct: 1181 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1240
Query: 674 DEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
AD V G +K G+ L ++ GI + +
Sbjct: 1241 STIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 68.6 bits (166), Expect = 5e-11
Identities = 60/241 (24%), Positives = 118/241 (48%), Gaps = 27/241 (11%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKC--- 1375
+S VKKG+ L L+G +G GKST++ +L +P +G VF+ D+ + + ++ K
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFV-DFGFQLLDGQEAKKLNVQ 1113
Query: 1376 -----MGYCPQINPLWPDTTLQEHFEIYG----------AVKGMSASDMKEVISRITHAL 1420
+G Q P+ D ++ E+ YG V A+++ I + H
Sbjct: 1114 WLRAQLGIVSQ-EPILFDCSIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY 1171
Query: 1421 DLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFK 1480
+ + + T +L G K+++ A +++ PQI LLDE ++ +D ++++ + A+ A
Sbjct: 1172 ETRVGDKGT--QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA-- 1227
Query: 1481 NRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIEN 1540
R I+ H + + D + + +G+++ GT Q L ++ G YF + ++ +N
Sbjct: 1228 REGRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGI-YFSMVSVQAGTQN 1285
Query: 1541 L 1541
L
Sbjct: 1286 L 1286
Score = 52.4 bits (124), Expect = 4e-06
Identities = 52/211 (24%), Positives = 97/211 (45%), Gaps = 19/211 (9%)
Query: 1287 KPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINIL 1346
KP + NL E++D SR K+ K ++ V+ G+ + L+G +G GKST + ++
Sbjct: 386 KPDSIKGNL--EFNDVHFSYPSRANVKIL-KGLNLKVQSGQTVALVGSSGCGKSTTVQLI 442
Query: 1347 VGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHF----------E 1396
+P G + + + + +G Q P+ TT+ E+ E
Sbjct: 443 QRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQ-EPVLFSTTIAENICYGRGNVTMDE 501
Query: 1397 IYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLL 1456
I AVK +A E I ++ D + + +L G K+++ A +++ NP+I LL
Sbjct: 502 IKKAVKEANAY---EFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLL 556
Query: 1457 DEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
DE ++ +D +++ + A+ A + R I
Sbjct: 557 DEATSALDTESEAEVQAALDKAREGRTTIVI 587
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 90.5 bits (223), Expect = 1e-17
Identities = 66/227 (29%), Positives = 112/227 (49%), Gaps = 16/227 (7%)
Query: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMF 552
NV+ L+ L+ + GQ AL+G SG GKST + ++ L P +G +I G + + +
Sbjct: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY 467
Query: 553 EARKMIGICPQLDIHFDVLTVEE------NLSILASIKGIPANNIIQEVQKVLLDLDMQT 606
R++IG+ Q + F E N+++ K + N + + K+ D T
Sbjct: 468 -LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD--T 524
Query: 607 IKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVT 666
+ + +LSGGQK+++++ A++ NPKILLLDE T+ +D S V L + R T
Sbjct: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 667 VFSTHFMD---EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
+ H + AD++A G++ GS L K G+ ++L
Sbjct: 585 IVIAHRLSTVRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 84.0 bits (206), Expect = 1e-15
Identities = 68/270 (25%), Positives = 124/270 (45%), Gaps = 30/270 (11%)
Query: 448 EELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEG 507
E L GNI+F+E++ + NV L+ LS ++ +G
Sbjct: 976 EGLKPDKFEGNITFNEVVFNYPTR--------------------ANVPVLQGLSLEVKKG 1015
Query: 508 QITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIH 567
Q AL+G SG GKST++ +L P G + G +++ + R +GI Q I
Sbjct: 1016 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW-LRAQLGIVSQEPIL 1074
Query: 568 FDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKD-------NQAKKLSGGQK 620
FD ++ EN++ + + + + I+ + + ++T+ ++ +LSGGQK
Sbjct: 1075 FDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1133
Query: 621 RKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILA 680
+++++ A++ P+ILLLDE T+ +D S +V L + R + H + A
Sbjct: 1134 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NA 1192
Query: 681 DRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
D V G +K G+ L ++ GI + +
Sbjct: 1193 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
Score = 67.4 bits (163), Expect = 1e-10
Identities = 58/233 (24%), Positives = 112/233 (48%), Gaps = 18/233 (7%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+S VKKG+ L L+G +G GKST++ +L +P +G V L ++ +G
Sbjct: 1008 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1067
Query: 1379 CPQINPLWPDTTLQEHFEIYG----------AVKGMSASDMKEVISRITHALDLKEHLQK 1428
Q P+ D ++ E+ YG V A+++ I + H + + +
Sbjct: 1068 VSQ-EPILFDCSIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG 1125
Query: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
T +L G K+++ A +++ PQI LLDE ++ +D ++++ + A+ A R I+
Sbjct: 1126 T--QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA--REGRTCIV 1181
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL 1541
H + + D + + +G+++ GT Q L ++ G YF + ++ +NL
Sbjct: 1182 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGI-YFSMVSVQAGTQNL 1232
Score = 52.4 bits (124), Expect = 4e-06
Identities = 52/211 (24%), Positives = 97/211 (45%), Gaps = 19/211 (9%)
Query: 1287 KPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINIL 1346
KP + NL E++D SR K+ K ++ V+ G+ + L+G +G GKST + ++
Sbjct: 386 KPDSIKGNL--EFNDVHFSYPSRANVKIL-KGLNLKVQSGQTVALVGSSGCGKSTTVQLI 442
Query: 1347 VGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHF----------E 1396
+P G + + + + +G Q P+ TT+ E+ E
Sbjct: 443 QRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQ-EPVLFSTTIAENICYGRGNVTMDE 501
Query: 1397 IYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLL 1456
I AVK +A E I ++ D + + +L G K+++ A +++ NP+I LL
Sbjct: 502 IKKAVKEANAY---EFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLL 556
Query: 1457 DEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
DE ++ +D +++ + A+ A + R I
Sbjct: 557 DEATSALDTESEAEVQAALDKAREGRTTIVI 587
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 90.5 bits (223), Expect = 1e-17
Identities = 66/227 (29%), Positives = 112/227 (49%), Gaps = 16/227 (7%)
Query: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMF 552
NV+ L+ L+ + GQ AL+G SG GKST + ++ L P +G +I G + + +
Sbjct: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY 467
Query: 553 EARKMIGICPQLDIHFDVLTVEE------NLSILASIKGIPANNIIQEVQKVLLDLDMQT 606
R++IG+ Q + F E N+++ K + N + + K+ D T
Sbjct: 468 -LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFD--T 524
Query: 607 IKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVT 666
+ + +LSGGQK+++++ A++ NPKILLLDE T+ +D S V L + R T
Sbjct: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 667 VFSTHFMD---EADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
+ H + AD++A G++ GS L K G+ ++L
Sbjct: 585 IVIAHRLSTVRNADVIAG----FEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 84.0 bits (206), Expect = 1e-15
Identities = 68/270 (25%), Positives = 124/270 (45%), Gaps = 30/270 (11%)
Query: 448 EELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEG 507
E L GNI+F+E++ + NV L+ LS ++ +G
Sbjct: 1023 EGLKPDKFEGNITFNEVVFNYPTR--------------------ANVPVLQGLSLEVKKG 1062
Query: 508 QITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIH 567
Q AL+G SG GKST++ +L P G + G +++ + R +GI Q I
Sbjct: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW-LRAQLGIVSQEPIL 1121
Query: 568 FDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKD-------NQAKKLSGGQK 620
FD ++ EN++ + + + + I+ + + ++T+ ++ +LSGGQK
Sbjct: 1122 FDC-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1180
Query: 621 RKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILA 680
+++++ A++ P+ILLLDE T+ +D S +V L + R + H + A
Sbjct: 1181 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NA 1239
Query: 681 DRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
D V G +K G+ L ++ GI + +
Sbjct: 1240 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 67.4 bits (163), Expect = 1e-10
Identities = 58/233 (24%), Positives = 112/233 (48%), Gaps = 18/233 (7%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+S VKKG+ L L+G +G GKST++ +L +P +G V L ++ +G
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
Query: 1379 CPQINPLWPDTTLQEHFEIYG----------AVKGMSASDMKEVISRITHALDLKEHLQK 1428
Q P+ D ++ E+ YG V A+++ I + H + + +
Sbjct: 1115 VSQ-EPILFDCSIAENI-AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKG 1172
Query: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
T +L G K+++ A +++ PQI LLDE ++ +D ++++ + A+ A R I+
Sbjct: 1173 T--QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA--REGRTCIV 1228
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL 1541
H + + D + + +G+++ GT Q L ++ G YF + ++ +NL
Sbjct: 1229 IAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGI-YFSMVSVQAGTQNL 1279
Score = 52.4 bits (124), Expect = 4e-06
Identities = 52/211 (24%), Positives = 97/211 (45%), Gaps = 19/211 (9%)
Query: 1287 KPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINIL 1346
KP + NL E++D SR K+ K ++ V+ G+ + L+G +G GKST + ++
Sbjct: 386 KPDSIKGNL--EFNDVHFSYPSRANVKIL-KGLNLKVQSGQTVALVGSSGCGKSTTVQLI 442
Query: 1347 VGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHF----------E 1396
+P G + + + + +G Q P+ TT+ E+ E
Sbjct: 443 QRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQ-EPVLFSTTIAENICYGRGNVTMDE 501
Query: 1397 IYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLL 1456
I AVK +A E I ++ D + + +L G K+++ A +++ NP+I LL
Sbjct: 502 IKKAVKEANAY---EFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLL 556
Query: 1457 DEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
DE ++ +D +++ + A+ A + R I
Sbjct: 557 DEATSALDTESEAEVQAALDKAREGRTTIVI 587
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 84.3 bits (207), Expect = 9e-16
Identities = 70/232 (30%), Positives = 114/232 (49%), Gaps = 11/232 (4%)
Query: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
TY + ++ + L LS I GQ A +G SG GKST + +L P G I GH
Sbjct: 1086 TYPSRPDS-QVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDS 1144
Query: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL-DLDM 604
+++ F R IGI Q + F ++ +N+ + K IP +I ++ L D M
Sbjct: 1145 KKVNVQF-LRSNIGIVSQEPVLF-ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVM 1202
Query: 605 ------QTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658
+T +Q +LS G+K+++++ A++ +PKILLLDE T+ +D S V L
Sbjct: 1203 SLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALD 1262
Query: 659 YRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
+ R + H + AD AV++QG++ G+ L ++ G Y+L
Sbjct: 1263 KAREGRTCIVIAHRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 77.4 bits (189), Expect = 1e-13
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 17/174 (9%)
Query: 494 VEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFE 553
V+ L +L+ I G++TAL+G SG GKST + ++ P +G ++ GH + ++ +
Sbjct: 435 VKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW- 493
Query: 554 ARKMIGICPQLDIHFDVLTVEENL----------SILASIKGIPANNIIQEVQKVLLDLD 603
R IGI Q + F T+ EN+ I+ + K A N I + L
Sbjct: 494 LRDQIGIVEQEPVLFST-TIAENIRYGREDATMEDIVQAAKEANAYNFIMD-----LPQQ 547
Query: 604 MQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLL 657
T+ ++SGGQK+++++ A++ NPKILLLD T+ +D S +V +L
Sbjct: 548 FDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVL 601
Score = 54.3 bits (129), Expect = 1e-06
Identities = 66/279 (23%), Positives = 122/279 (43%), Gaps = 28/279 (10%)
Query: 1272 RLKVKELMGCQCCEEKPSIMVSNLHKE----YDDKKDFL------LSRKVKKVATKYISF 1321
+ K+ Q + +P I V N E + K DF+ SR +V +S
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNG-LSV 1101
Query: 1322 CVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQ 1381
+ G+ L +G +G GKST I +L +P G+V + + S+ +G Q
Sbjct: 1102 SISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQ 1161
Query: 1382 INPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA------LDLKEHLQKTV----K 1431
P+ ++ ++ + YG M+ VI+ A + L E + V
Sbjct: 1162 -EPVLFACSIMDNIK-YG--DNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGS 1217
Query: 1432 KLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTH 1491
+L G K+++ A +++ +P+I LLDE ++ +D ++++ + A+ A R I+ H
Sbjct: 1218 QLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKA--REGRTCIVIAH 1275
Query: 1492 YMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFL 1530
+ + D +A+M G + GT + L ++ G Y L
Sbjct: 1276 RLSTIQN-ADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/160 (23%), Positives = 76/160 (47%), Gaps = 16/160 (10%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
++ +K GE+ L+GP+GAGKST + ++ +P G V + + + +G
Sbjct: 441 LNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGI 500
Query: 1379 CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA------LDLKEHLQKTV-- 1430
Q P+ TT+ E+ G + M++++ A +DL + V
Sbjct: 501 VEQ-EPVLFSTTIAENIRY-----GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGE 554
Query: 1431 --KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAK 1468
++ G K+++ A +++ NP+I LLD ++ +D +++
Sbjct: 555 GGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESE 594
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 84.0 bits (206), Expect = 1e-15
Identities = 56/216 (25%), Positives = 111/216 (51%), Gaps = 17/216 (7%)
Query: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
TYR + + + L+N+SF + G++TAL+G SG+GKS+ +NIL P G + G +
Sbjct: 469 TYRTR-PHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 527
Query: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV-----LL 600
S D + ++I + Q + F ++ +N+S + +P +++ QK ++
Sbjct: 528 SAYDHKY-LHRVISLVSQEPVLF-ARSITDNISY--GLPTVPFEMVVEAAQKANAHGFIM 583
Query: 601 DLD--MQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658
+L T + +LSGGQK+++++ A++ NP +L+LDE T+ +D S +++ +
Sbjct: 584 ELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH 643
Query: 659 YRKANRVTVFSTHFMDEAD-----ILADRKAVISQG 689
+ H + + ++ D+ V+ QG
Sbjct: 644 GNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 679
Score = 47.0 bits (110), Expect = 2e-04
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 19/217 (8%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+SF + G++ L+GP+G+GKS+ +NIL G+V L D ++ D L +
Sbjct: 482 VSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL-DGKPISAYDHKYLHRVIS 540
Query: 1379 CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA------LDLKE-HLQKTVK 1431
P+ ++ ++ G+ + V+ A ++L++ + +T +
Sbjct: 541 LVSQEPVLFARSITDNISY-----GLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 595
Query: 1432 K---LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
K L G K+++ A +++ NP + +LDE ++ +D +++ + +AI +K ++
Sbjct: 596 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNL--QKHTVLI 653
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFG 1525
H + E + ++ G++ GT Q L ++ G
Sbjct: 654 IAHRLSTVEH-AHLIVVLDKGRVVQQGTHQQLLAQGG 689
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 84.0 bits (206), Expect = 1e-15
Identities = 56/216 (25%), Positives = 111/216 (51%), Gaps = 17/216 (7%)
Query: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
TYR + + + L+N+SF + G++TAL+G SG+GKS+ +NIL P G + G +
Sbjct: 512 TYRTR-PHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV-----LL 600
S D + ++I + Q + F ++ +N+S + +P +++ QK ++
Sbjct: 571 SAYDHKY-LHRVISLVSQEPVLF-ARSITDNISY--GLPTVPFEMVVEAAQKANAHGFIM 626
Query: 601 DLD--MQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658
+L T + +LSGGQK+++++ A++ NP +L+LDE T+ +D S +++ +
Sbjct: 627 ELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH 686
Query: 659 YRKANRVTVFSTHFMDEAD-----ILADRKAVISQG 689
+ H + + ++ D+ V+ QG
Sbjct: 687 GNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
Score = 47.0 bits (110), Expect = 2e-04
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 19/217 (8%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+SF + G++ L+GP+G+GKS+ +NIL G+V L D ++ D L +
Sbjct: 525 VSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL-DGKPISAYDHKYLHRVIS 583
Query: 1379 CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA------LDLKE-HLQKTVK 1431
P+ ++ ++ G+ + V+ A ++L++ + +T +
Sbjct: 584 LVSQEPVLFARSITDNISY-----GLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 638
Query: 1432 K---LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
K L G K+++ A +++ NP + +LDE ++ +D +++ + +AI +K ++
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNL--QKHTVLI 696
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFG 1525
H + E + ++ G++ GT Q L ++ G
Sbjct: 697 IAHRLSTVEH-AHLIVVLDKGRVVQQGTHQQLLAQGG 732
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 84.0 bits (206), Expect = 1e-15
Identities = 56/216 (25%), Positives = 111/216 (51%), Gaps = 17/216 (7%)
Query: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
TYR + + + L+N+SF + G++TAL+G SG+GKS+ +NIL P G + G +
Sbjct: 512 TYRTR-PHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV-----LL 600
S D + ++I + Q + F ++ +N+S + +P +++ QK ++
Sbjct: 571 SAYDHKY-LHRVISLVSQEPVLF-ARSITDNISY--GLPTVPFEMVVEAAQKANAHGFIM 626
Query: 601 DLD--MQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658
+L T + +LSGGQK+++++ A++ NP +L+LDE T+ +D S +++ +
Sbjct: 627 ELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIH 686
Query: 659 YRKANRVTVFSTHFMDEAD-----ILADRKAVISQG 689
+ H + + ++ D+ V+ QG
Sbjct: 687 GNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
Score = 47.0 bits (110), Expect = 2e-04
Identities = 47/217 (21%), Positives = 102/217 (47%), Gaps = 19/217 (8%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+SF + G++ L+GP+G+GKS+ +NIL G+V L D ++ D L +
Sbjct: 525 VSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL-DGKPISAYDHKYLHRVIS 583
Query: 1379 CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA------LDLKE-HLQKTVK 1431
P+ ++ ++ G+ + V+ A ++L++ + +T +
Sbjct: 584 LVSQEPVLFARSITDNISY-----GLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 638
Query: 1432 K---LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
K L G K+++ A +++ NP + +LDE ++ +D +++ + +AI +K ++
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNL--QKHTVLI 696
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFG 1525
H + E + ++ G++ GT Q L ++ G
Sbjct: 697 IAHRLSTVEH-AHLIVVLDKGRVVQQGTHQQLLAQGG 732
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 82.0 bits (201), Expect = 4e-15
Identities = 66/225 (29%), Positives = 109/225 (48%), Gaps = 10/225 (4%)
Query: 493 NVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMF 552
+V LR LS I G+ A +G SG GKST + +L L P G G E++ +
Sbjct: 584 DVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQW 643
Query: 553 EARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDN-- 610
R I I PQ + F+ ++ EN++ + + +P + I + + ++ + +
Sbjct: 644 -LRSQIAIVPQEPVLFNC-SIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYN 701
Query: 611 -----QAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
+ +LSGGQK++L++ A+L PKILLLDE T+ +D S +V + L + R
Sbjct: 702 TQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRT 761
Query: 666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
+ TH + A AD V+ G +K G+ L I ++L
Sbjct: 762 CLVVTHRL-SAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
Score = 60.8 bits (146), Expect = 1e-08
Identities = 39/121 (32%), Positives = 63/121 (52%), Gaps = 1/121 (0%)
Query: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
T+ + ++SGGQK+++++ A++ NPKIL+LDE T+ +D S+ V L+ R
Sbjct: 71 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRT 130
Query: 666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSS 725
T+ H + AD + GML G+ L +K G+ Y L M D A E + S
Sbjct: 131 TIVVAHRLSTIR-SADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMES 189
Query: 726 L 726
+
Sbjct: 190 M 190
Score = 57.8 bits (138), Expect = 9e-08
Identities = 51/212 (24%), Positives = 96/212 (45%), Gaps = 17/212 (8%)
Query: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGY 1378
+S +++G+ + +G +G GKST + +L +P GQV ++ +
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
Query: 1379 CPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV-----ISRITHALDLKEHLQKTVK-- 1431
PQ P+ + ++ E+ + + ++KE I L K + Q +K
Sbjct: 651 VPQ-EPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGA 709
Query: 1432 KLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD---PKAKQHMWRAIRTAFKNRKRAAIL 1488
+L G K++L A ++L P+I LLDE ++ +D K QH RT R ++
Sbjct: 710 QLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTG-----RTCLV 764
Query: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHL 1520
TH + + D + ++ +G+++ GT Q L
Sbjct: 765 VTHRLSAIQN-ADLIVVLHNGKIKEQGTHQEL 795
Score = 43.9 bits (102), Expect = 0.001
Identities = 35/177 (19%), Positives = 83/177 (46%), Gaps = 19/177 (10%)
Query: 1432 KLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTH 1491
++ G K+++ A +++ NP+I +LDE ++ +D ++K + A+ A K R I+ H
Sbjct: 79 QMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKG--RTTIVVAH 136
Query: 1492 YMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQ 1551
+ + D + + G L G L +K G Y L + + ++ + +++
Sbjct: 137 RLSTIRS-ADLIVTLKDGMLAEKGAHAELMAKRGLYYSL-------VMSQDIKKADEQME 188
Query: 1552 YIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQV 1608
+ + R+ + +P V+S+ F +++A+ + +E S + +L ++
Sbjct: 189 SMTYSTERKTN-------SLPLHSVKSIKSDF--IDKAEESTQSKEISLPEVSLLKI 236
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 81.6 bits (200), Expect = 6e-15
Identities = 64/211 (30%), Positives = 109/211 (51%), Gaps = 9/211 (4%)
Query: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546
+RKKG L+ +S G++ A++G SG GKSTLMNIL G A +
Sbjct: 89 WRKKGYKT-LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPR 147
Query: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605
++ RK+ Q D+ LTV+E + + A +K + +E V+++L L +
Sbjct: 148 DLRCF---RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLL 204
Query: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
+ + + LSGGQ+++L++ + ++ NP ++ DEPT+G+D S V +L+K
Sbjct: 205 SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGR 264
Query: 666 TVFSTHFMDEADI--LADRKAVISQGMLKCV 694
++ T A + L D+ V+SQG +CV
Sbjct: 265 SIICTIHQPSAKLFELFDQLYVLSQG--QCV 293
Score = 69.3 bits (168), Expect = 3e-11
Identities = 49/162 (30%), Positives = 77/162 (47%), Gaps = 13/162 (8%)
Query: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETS 1367
+K K K IS GE++ ++GP+GAGKST++NIL G E G V + +
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 148
Query: 1368 EDDDSLKCMG----YCPQINPLWPDTTLQEHFEIYGAVKGMSASD-MKEVISRITHALDL 1422
L+C Y Q + L P T+QE + +K + +E++ I AL L
Sbjct: 149 -----LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGL 203
Query: 1423 KEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464
L G +++L AL ++ NP + DEP++G+D
Sbjct: 204 LSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLD 245
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 81.6 bits (200), Expect = 6e-15
Identities = 64/211 (30%), Positives = 109/211 (51%), Gaps = 9/211 (4%)
Query: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546
+RKKG L+ +S G++ A++G SG GKSTLMNIL G A +
Sbjct: 70 WRKKGYKT-LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPR 128
Query: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605
++ RK+ Q D+ LTV+E + + A +K + +E V+++L L +
Sbjct: 129 DLRCF---RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLL 185
Query: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
+ + + LSGGQ+++L++ + ++ NP ++ DEPT+G+D S V +L+K
Sbjct: 186 SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGR 245
Query: 666 TVFSTHFMDEADI--LADRKAVISQGMLKCV 694
++ T A + L D+ V+SQG +CV
Sbjct: 246 SIICTIHQPSAKLFELFDQLYVLSQG--QCV 274
Score = 69.3 bits (168), Expect = 3e-11
Identities = 49/162 (30%), Positives = 77/162 (47%), Gaps = 13/162 (8%)
Query: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETS 1367
+K K K IS GE++ ++GP+GAGKST++NIL G E G V + +
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 129
Query: 1368 EDDDSLKCMG----YCPQINPLWPDTTLQEHFEIYGAVKGMSASD-MKEVISRITHALDL 1422
L+C Y Q + L P T+QE + +K + +E++ I AL L
Sbjct: 130 -----LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGL 184
Query: 1423 KEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464
L G +++L AL ++ NP + DEP++G+D
Sbjct: 185 LSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLD 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,973,254
Number of Sequences: 37866
Number of extensions: 2362043
Number of successful extensions: 7791
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 7083
Number of HSP's gapped (non-prelim): 390
length of query: 1642
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1526
effective length of database: 13,855,062
effective search space: 21142824612
effective search space used: 21142824612
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.