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Search of human proteins with 26080431
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|26080431 ATPase family, AAA domain containing 5 [Homo
sapiens]
(1844 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] 3640 0.0
gi|32528306 replication factor C large subunit [Homo sapiens] 85 6e-16
gi|87299628 biorientation of chromosomes in cell division 1-like... 73 2e-12
gi|71061468 centromere protein E [Homo sapiens] 66 3e-10
gi|27501458 CTF18, chromosome transmission fidelity factor 18 ho... 58 7e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 2e-07
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 55 5e-07
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 55 5e-07
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 55 6e-07
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 55 6e-07
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 54 2e-06
gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo... 51 9e-06
gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo ... 51 9e-06
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 51 1e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 51 1e-05
gi|216548091 leucine zipper protein 1 [Homo sapiens] 51 1e-05
gi|216548085 leucine zipper protein 1 [Homo sapiens] 51 1e-05
gi|19718796 RAD17 homolog isoform 1 [Homo sapiens] 51 1e-05
gi|19718794 RAD17 homolog isoform 1 [Homo sapiens] 51 1e-05
gi|19718792 RAD17 homolog isoform 1 [Homo sapiens] 51 1e-05
gi|19718784 RAD17 homolog isoform 1 [Homo sapiens] 51 1e-05
gi|4506383 RAD17 homolog isoform 1 [Homo sapiens] 51 1e-05
gi|19718786 RAD17 homolog isoform 2 [Homo sapiens] 51 1e-05
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 50 3e-05
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 50 3e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 5e-05
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 49 6e-05
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 49 6e-05
gi|150456436 hypothetical protein LOC55719 isoform 1 [Homo sapiens] 47 1e-04
gi|209915547 hypothetical protein LOC55719 isoform 2 [Homo sapiens] 47 1e-04
>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
Length = 1844
Score = 3640 bits (9438), Expect = 0.0
Identities = 1844/1844 (100%), Positives = 1844/1844 (100%)
Query: 1 MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPS 60
MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPS
Sbjct: 1 MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPS 60
Query: 61 NILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLS 120
NILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLS
Sbjct: 61 NILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLS 120
Query: 121 HQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPN 180
HQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPN
Sbjct: 121 HQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPN 180
Query: 181 TMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQME 240
TMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQME
Sbjct: 181 TMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQME 240
Query: 241 NTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIV 300
NTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIV
Sbjct: 241 NTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIV 300
Query: 301 KSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPEN 360
KSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPEN
Sbjct: 301 KSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPEN 360
Query: 361 EQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVK 420
EQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVK
Sbjct: 361 EQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVK 420
Query: 421 KSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKK 480
KSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKK
Sbjct: 421 KSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKK 480
Query: 481 KNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLV 540
KNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLV
Sbjct: 481 KNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLV 540
Query: 541 YEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRI 600
YEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRI
Sbjct: 541 YEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRI 600
Query: 601 SSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFT 660
SSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFT
Sbjct: 601 SSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFT 660
Query: 661 RISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKV 720
RISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKV
Sbjct: 661 RISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKV 720
Query: 721 TEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKK 780
TEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKK
Sbjct: 721 TEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKK 780
Query: 781 LNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMS 840
LNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMS
Sbjct: 781 LNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMS 840
Query: 841 GLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELN 900
GLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELN
Sbjct: 841 GLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELN 900
Query: 901 TKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSL 960
TKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSL
Sbjct: 901 TKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSL 960
Query: 961 KKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNL 1020
KKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNL
Sbjct: 961 KKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNL 1020
Query: 1021 EKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWL 1080
EKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWL
Sbjct: 1021 EKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWL 1080
Query: 1081 KDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTA 1140
KDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTA
Sbjct: 1081 KDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTA 1140
Query: 1141 AVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGK 1200
AVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGK
Sbjct: 1141 AVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGK 1200
Query: 1201 SPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENN 1260
SPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENN
Sbjct: 1201 SPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENN 1260
Query: 1261 KGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNA 1320
KGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNA
Sbjct: 1261 KGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNA 1320
Query: 1321 IKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVK 1380
IKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVK
Sbjct: 1321 IKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVK 1380
Query: 1381 DFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIY 1440
DFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIY
Sbjct: 1381 DFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIY 1440
Query: 1441 PKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQ 1500
PKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQ
Sbjct: 1441 PKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQ 1500
Query: 1501 MRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKK 1560
MRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKK
Sbjct: 1501 MRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKK 1560
Query: 1561 SQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNP 1620
SQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNP
Sbjct: 1561 SQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNP 1620
Query: 1621 ETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWT 1680
ETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWT
Sbjct: 1621 ETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWT 1680
Query: 1681 NGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRD 1740
NGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRD
Sbjct: 1681 NGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRD 1740
Query: 1741 PTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPT 1800
PTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPT
Sbjct: 1741 PTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPT 1800
Query: 1801 LRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAADFP 1844
LRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAADFP
Sbjct: 1801 LRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAADFP 1844
>gi|32528306 replication factor C large subunit [Homo sapiens]
Length = 1147
Score = 85.1 bits (209), Expect = 6e-16
Identities = 167/783 (21%), Positives = 317/783 (40%), Gaps = 116/783 (14%)
Query: 412 SDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFL 471
S+ +K K SD++ +K + E+ NS + ++ + SK + +D S
Sbjct: 18 SETVKKNEKTKSDEETLKAKKGIKEI--KVNSSRKEDDFKQKQPSKKKRIIYDSDSESEE 75
Query: 472 KEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSS 531
+ K KK +K +P ++ G +++ ++ E ++ ++ ++ ++
Sbjct: 76 TLQVKNAKKPPEK------LPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENG 129
Query: 532 TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTP 591
N+ L S++ N + ++ + P+ IKLT + S+L+
Sbjct: 130 RSTNSH------------LGTSNMKKNEENTKTKNKPLSPIKLTPT------SVLDYFGT 171
Query: 592 KSTRRSGR-ISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFD 650
S +RS + + ++ E + D + D + K L E AEL +
Sbjct: 172 GSVQRSNKKMVASKRKELSQNTDESGLNDEA-----IAKQLQLDED-----AELERQLHE 221
Query: 651 SESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKA 710
E R PK KK+ K +E E S+ N+SKA EK
Sbjct: 222 DEEFARTLAMLDEEPKT--KKARKDTEAGETF-----------SSVQANLSKA----EKH 264
Query: 711 KALH-ISRSKVTEEI-AIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKH----PE 764
K H + ++V++E + R+ S++++ E ++ S++ I SSP A
Sbjct: 265 KYPHKVKTAQVSDERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKR 324
Query: 765 KNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDES-SQDTSEK 823
K + + + V K+ + K + G+ K K P+ ES S + SEK
Sbjct: 325 KEESSYKEIEPVASKRKENAIK-LKGETKTP---------KKTKSSPAKKESVSPEDSEK 374
Query: 824 SQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLW 883
+ +A R +L P L + K A + + V+ ++D+
Sbjct: 375 KR---TNYQAYRSYLNREGPKALGSKEIPKGAE-NCLEGLIFVITGVLESIERDE----- 425
Query: 884 HLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKE--FTE 941
+ L+ ++ T + + +G S + KS +AA+ + E
Sbjct: 426 -----AKSLIERYGGKVTGNVSKKTNYLVMGRDS---GQSKSDKAAALGTKIIDEDGLLN 477
Query: 942 EVRNLLLEEIRWSNP-EFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKL 1000
+R + ++ ++ E +KK L Q Q SK+E E+ S +KR
Sbjct: 478 LIRTMPGKKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDS 537
Query: 1001 VEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQP 1060
+ +K+ +K+ + + K+L+ + +EE S + + + DSS++ E++LW +KY+P
Sbjct: 538 L----AKTIKKETDVFWKSLDFKEQVAEETSGDSKARNLADDSSENK-VENLLWVDKYKP 592
Query: 1061 QTASELIG---NELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSD 1117
+ +IG ++ KL WL++W++ + D+KH F F G D
Sbjct: 593 TSLKTIIGQQGDQSCANKLLRWLRNWQKSSS----------EDKKHAKFG---KFSGKDD 639
Query: 1118 DEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQS 1177
L++GP GVGKT QELG+ E+NAS RS + + + E+ +
Sbjct: 640 GSS----FKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNN 695
Query: 1178 HQV 1180
+
Sbjct: 696 TSI 698
Score = 37.7 bits (86), Expect = 0.10
Identities = 142/658 (21%), Positives = 261/658 (39%), Gaps = 96/658 (14%)
Query: 252 VTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENS 311
V+E + N+ T S EE LK+ K K ++ S + + + Y S+SE+
Sbjct: 17 VSETVKKNEK--TKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSESE 74
Query: 312 EISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNV 371
E Q K V P K + + P ++ + E + ++ R +N
Sbjct: 75 ETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTNS 134
Query: 372 VIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNE 431
+ ++ E + KP ++ + + S ++ K + K+K+L++
Sbjct: 135 HLGTSNMKKN--EENTKTKNKPLSPIKLTPTSVLDYFGTGS-VQRSNKKMVASKRKELSQ 191
Query: 432 KCLYEVGRDDNS--KKIMENSGIQMVSKNGNLQLHTDKG-----SFLKEKNKKLKKKNKK 484
E G +D + K++ + ++ QLH D+ + L E+ K KK +K
Sbjct: 192 NT-DESGLNDEAIAKQLQLDEDAEL-----ERQLHEDEEFARTLAMLDEEPKT--KKARK 243
Query: 485 TLDTGAIPGKNREGNTQKKETTFFLKEKQYQ---NRMSLRQRKTEFFKSSTLFNNESLVY 541
+ G + ++ ++ + K K Q R S RK ++SS ES +
Sbjct: 244 DTEAGETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQSKYESS----KESQQH 299
Query: 542 EDIANDDLLKVSSLCNNNKLS---RKTSIPVKDIKLTQSKAESEASLLN--VSTPKSTRR 596
+ D + +VSS ++KL+ RK K+I+ SK + A L TPK T+
Sbjct: 300 SKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTK- 358
Query: 597 SGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIR 656
SS E++ DS+ + N Q S N +L + E +P +E+ +
Sbjct: 359 ----SSPAKKESVSPEDSEKKRTNYQAYRSY---LNREGPKALGSKE---IPKGAENCLE 408
Query: 657 MKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASN---TSKNISKAKQLIEKAKAL 713
I+ +S ++ +S E G T + K +N ++ ++K +KA AL
Sbjct: 409 GLIFVITGVLESIERDEAKS-LIERYGGKVTGNVSKKTNYLVMGRDSGQSKS--DKAAAL 465
Query: 714 HISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCL 773
+K+ +E + + +T+P +K E A++ K + KL+
Sbjct: 466 G---TKIIDEDGL----LNLIRTMPGKKSKYEI------------AVETEMKKESKLE-- 504
Query: 774 NDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKS--QDCDVQC 831
T KNV GK K++P ++K ++ S S +D+ K+ ++ DV
Sbjct: 505 --------RTPQKNVQGKRKISP------SKKESESKKSRPTSKRDSLAKTIKKETDVFW 550
Query: 832 KA---KRDFLMSGLPDLLKRQIAKKAAALDVYNAV------STSFQRVVHVQQKDDGC 880
K+ K D R +A ++ V N + TS + ++ QQ D C
Sbjct: 551 KSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIG-QQGDQSC 607
Score = 36.2 bits (82), Expect = 0.30
Identities = 127/652 (19%), Positives = 247/652 (37%), Gaps = 89/652 (13%)
Query: 162 KKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVV-----DL 216
KK V + + TKS T+ + + K++ ++DFK+ + K + ++ +
Sbjct: 14 KKLVSETVKKNEKTKSDEETLKAKKGIKEIKVNSSRKEDDFKQKQPSKKKRIIYDSDSES 73
Query: 217 SESLPL------AEELNLLKKDGKDTKQMENT-TSHANSRDN------VTEAAQLNDSII 263
E+L + E+L + K GK ++Q T S + D+ +++ + S
Sbjct: 74 EETLQVKNAKKPPEKLPVSSKPGKISRQDPVTYISETDEEDDFMCKKAASKSKENGRSTN 133
Query: 264 TVSYEEFLKSHKEN-KVEEIPDSTMSICVPSETVD-----EIVKSG-YISESENSEISQQ 316
+ +K ++EN K + P S + + P+ +D + +S + S+ E+SQ
Sbjct: 134 SHLGTSNMKKNEENTKTKNKPLSPIKL-TPTSVLDYFGTGSVQRSNKKMVASKRKELSQN 192
Query: 317 VRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEE 376
+ A + + ++ R + ++F ++ D E +T + RK E
Sbjct: 193 TDESGLNDEAIAKQLQLDEDAELERQLHEDEEFARTLAMLD-EEPKTKKARKDT----EA 247
Query: 377 ELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYE 436
+ ++A S+A K K + + + R+ S ++ K S K+ + K +
Sbjct: 248 GETFSSVQANLSKAEKHKYPHKVKTAQVSDERKSYSPRKQS--KYESSKESQQHSKSSAD 305
Query: 437 VGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNR 496
+ +S K I + + + S KE KLK + K T + P K
Sbjct: 306 KIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPKKTKSSPAKKE 365
Query: 497 EGNTQ--KKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVY------EDIANDD 548
+ + +K+ T + + Y NR + ++ E L++ E I D+
Sbjct: 366 SVSPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITGVLESIERDE 425
Query: 549 ---LLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPT 605
L++ +S+KT+ V QSK++ A+L
Sbjct: 426 AKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAAL-------------------- 465
Query: 606 TETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTP 665
+ ID D + + K S Y + ++E K R TP
Sbjct: 466 --GTKIIDEDGL---------LNLIRTMPGKKSKY-----EIAVETEMKKESKLER--TP 507
Query: 666 KKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIA 725
+K+ + K S + S+ +K+ TSK S AK I+K + E++A
Sbjct: 508 QKNVQGKRKISPSKK------ESESKKSRPTSKRDSLAK-TIKKETDVFWKSLDFKEQVA 560
Query: 726 IPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVL 777
S+ + L + ++ E+ + + PT+LK Q C N +L
Sbjct: 561 EETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLL 612
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 73.2 bits (178), Expect = 2e-12
Identities = 157/722 (21%), Positives = 301/722 (41%), Gaps = 86/722 (11%)
Query: 152 VESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCR 211
VE + + + +L +++Q S+ ++ + KK + + K + KK +K K
Sbjct: 287 VEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNE---KGERKKEKKEKTE 343
Query: 212 DVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFL 271
D S+ +++ KD K K+ E + S N +A + + E+F
Sbjct: 344 KKFDHSKKSEDTQKV----KDEKQAKEKEVESLKLPSEKNSNKAKTVEGT-----KEDF- 393
Query: 272 KSHKENKVEEIPDSTMSICVPSE-------TVDEIVKSGYISE----SENSEISQQVRFK 320
S ++ V+ + D T+S S+ T +E+V S + E S++ E ++Q + K
Sbjct: 394 -SLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
Query: 321 TVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELEL 380
T T + + + + +L K + SD ++E TV++R+ ++ ++EE L
Sbjct: 453 TQTSDSSEGKTKSVRHAYVHKPYLYSKYY------SDSDDELTVEQRRQSIAKEKEERLL 506
Query: 381 A-------VLEAGSSEAVKPKCTLEERQQFMKAFRQPAS----DALKNGVKKSSDKQKDL 429
+ E +A K K + + Q + +S + +K+ ++K L
Sbjct: 507 RRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVL 566
Query: 430 NEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTG 489
+K R +S+ + ENS + + + + T K S EK K K K +
Sbjct: 567 EKKVALSKKRKKDSRNVEENSKKKQQYEEDSKE--TLKTSEHCEKEKISSSKELKHVHAK 624
Query: 490 AIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDL 549
+ P K + E+ + E + ++++ ++ ++ST E + E D
Sbjct: 625 SEPSKPAR---RLSESLHVVDENKNESKLEREHKR----RTSTPVIMEGVQEETDTRDVK 677
Query: 550 LKV--SSLCNNNKLSRKTSIP-VKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTT 606
+V S +C +K+++ K +K S+ SLL KS++ TP+
Sbjct: 678 RQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEV-KSSKEKPEREKTPS- 735
Query: 607 ETIRGIDSDDVQDNSQLKASTQ-KAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTP 665
D + + K K + +E HS + +S + T++S+
Sbjct: 736 -------EDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQS----QQTKLSSD 784
Query: 666 KKSKKKSNKRSEKSEAT---DGGFTSQ--IRKASNTSKNISKAKQLI--EKAKALHISRS 718
K+++KS R+E+ + DG S+ I+ N K +K ++ + EK KA H SR
Sbjct: 785 DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRR 844
Query: 719 KVTEEIAIPLRRSSRHQTLPERKKLSETEDSVII----IDSS--PTALKHPEKNQKKLQC 772
+I S +H +R+ S +ED + +DS+ P + H EK + K
Sbjct: 845 SSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTK-SL 903
Query: 773 LNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQK-AADPVPSFDESSQDT-SEKSQDCDVQ 830
L + L L + +K ++KV L A K A P P ++++++ SEK + V+
Sbjct: 904 LEEKL--VLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVE 961
Query: 831 CK 832
K
Sbjct: 962 DK 963
Score = 57.4 bits (137), Expect = 1e-07
Identities = 149/721 (20%), Positives = 272/721 (37%), Gaps = 113/721 (15%)
Query: 453 QMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGA--------------IPGKNRE- 497
+ SK Q TD + + ++ + K K T D+G +P E
Sbjct: 231 ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEI 290
Query: 498 GNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCN 557
N K+ L K Q S ++ K+ +NE + + K +
Sbjct: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK---GERKKEKKEKTEKKFD 347
Query: 558 NNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDV 617
++K S T VKD K Q+K E E L + + K++ ++ + T E IDSD V
Sbjct: 348 HSKKSEDTQ-KVKDEK--QAK-EKEVESLKLPSEKNSNKAKTVEGTK--EDFSLIDSD-V 400
Query: 618 QDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSE 677
+ + S+ ++LS E++T S+S M+ I++ + K K NK
Sbjct: 401 DGLTDITVSSVHTSDLSSFEEDTEEEVVT----SDS---MEEGEITSDDEEKNKQNKTKT 453
Query: 678 KSEATDGGFTSQIRKA--------------SNTSKNISKAKQLIEKAKALHISRSKVTEE 723
++ + G T +R A S+ + + +Q I K K + R ++ E
Sbjct: 454 QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINRE 513
Query: 724 IAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNT 783
R+ +T + K + SV + +SS +L+ K++ VL KK+
Sbjct: 514 KLEEKRKQKAEKTKSSKTK-GQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVAL 572
Query: 784 STKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLP 843
S K R ++ + ++E S++T + S+ C+ + +S
Sbjct: 573 SKKRKKDS---------RNVEENSKKKQQYEEDSKETLKTSEHCEKE-------KISSSK 616
Query: 844 DLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKV 903
+L + + K+ +S S VV + + H + S P++ + + T
Sbjct: 617 EL--KHVHAKSEPSKPARRLSESLH-VVDENKNESKLEREHKRRTSTPVIMEGVQEETDT 673
Query: 904 IDLSKCGIALGEFSTLN-SKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSN--PE--- 957
D+ + + E T K KS ++ T +++LL +E++ S PE
Sbjct: 674 RDVKR-QVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREK 732
Query: 958 ------FSLKKYFP-------------------LLLKKQIEHQVLSSECHSKQELEADVS 992
S+K + L +++ I+ Q ++ S + E
Sbjct: 733 TPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK 792
Query: 993 HKETKRKLVEAENSK-----------SKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKL 1041
H+ ++ V ++ K + RK+ N+ + L K+E S+R++ S I+
Sbjct: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852
Query: 1042 DS--SKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAE--LEERQNLKG 1097
DS SK G +E Y N + K + KRR + LEE+ LK
Sbjct: 853 DSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKS 912
Query: 1098 K 1098
K
Sbjct: 913 K 913
Score = 53.9 bits (128), Expect = 1e-06
Identities = 141/700 (20%), Positives = 272/700 (38%), Gaps = 88/700 (12%)
Query: 68 KTSPTNEKTQLGKECKIKSPESVPVD---------SNKDCTTPLEMFSNVEFKKKRKRVN 118
K + T +T E K KS V S+ D +E K+K +R+
Sbjct: 447 KQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERL- 505
Query: 119 LSHQLNNIKTEN---EAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDT 175
L Q+N K E + + S +K + D ESST K +E A I++
Sbjct: 506 LRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST------KSLEPKAARIKEV 559
Query: 176 KSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKD 235
+ L+ ++ K+ + ++ K+K + D E+L +E K+
Sbjct: 560 LKERKV---LEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCE--KEKISS 614
Query: 236 TKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSET 295
+K++++ HA S + A +L++S+ V ++ E+K+E S V E
Sbjct: 615 SKELKHV--HAKSEPS-KPARRLSESLHVVD-----ENKNESKLEREHKRRTSTPVIMEG 666
Query: 296 VDEIVKSGYISES-ENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENS 354
V E + + E SEI + K + L + K + P + K+ E+++S
Sbjct: 667 VQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLK-KDDSETPHLKSLLKK-EVKSS 724
Query: 355 LSDPENEQTVQKRKSNVVIQE---------EELELAVLEAGSSEAVKPKCTLEERQQFMK 405
PE E+T + K +V + +E EL E G +EE Q
Sbjct: 725 KEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLK--------VEENIQKQS 776
Query: 406 AFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHT 465
+ +SD K+ K K NE+ L +G+D K + E ++ + N++
Sbjct: 777 QQTKLSSD------DKTERKSKHRNERKLSVLGKD--GKPVSE----YIIKTDENVR--- 821
Query: 466 DKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKT 525
KE NKK ++ + + ++ + QK L KQ+ ++L++R
Sbjct: 822 ------KENNKKERRLSAEKTKAEHKSRRSSDSKIQKDS----LGSKQHG--ITLQRRSE 869
Query: 526 EFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASL 585
+ + ++ ++ D LK + + K R+T +++ + +SK++++
Sbjct: 870 SYSEDKCDMDSTNM-------DSNLKPEEVVHKEK--RRTKSLLEEKLVLKSKSKTQGKQ 920
Query: 586 LNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELI 645
+ V + + + ++TP + + + +D + + K + + L TA
Sbjct: 921 VKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSS 980
Query: 646 TVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQ 705
+S R K KS K S + + +DG + ++ +S K + K
Sbjct: 981 AHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKS 1040
Query: 706 LIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSE 745
+ K + S K ++ ++ SR R LS+
Sbjct: 1041 DDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ 1080
Score = 38.9 bits (89), Expect = 0.047
Identities = 86/391 (21%), Positives = 159/391 (40%), Gaps = 49/391 (12%)
Query: 966 LLLKKQIEHQVLSSECHS--KQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKT 1023
+LL K ++ + + S K E + D + K ++K K K +K ++SK E T
Sbjct: 301 ILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKK-----EKKEKTEKKFDHSKKSEDT 355
Query: 1024 NR-KSEELSKRNNSSGIKLDSSKDSG-TEDMLWTEKYQPQTASELIG-NELAIKKLHSWL 1080
+ K E+ +K +KL S K+S + + T++ S++ G ++ + +H+
Sbjct: 356 QKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHT-- 413
Query: 1081 KDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTA 1140
D E E + + E+ E +SDDEE+++ T T + GKT
Sbjct: 414 SDLSSFEEDTEEEVVTSDSMEEGEI---------TSDDEEKNKQNKTKTQTSDSSEGKTK 464
Query: 1141 AV---YACAQELGFKIF---EVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFN 1194
+V Y L K + + + ++ + I + +E Q++++ + ++
Sbjct: 465 SVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRK---- 520
Query: 1195 SYYIGKSPK-KISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPK---PKNN 1250
K+ K K S K S + S KS PK A + L + K K
Sbjct: 521 ----QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKR 576
Query: 1251 EEIGMLLENNKGIKNSFEQ--KQITQT-----KSTNATNSNVKDVGAEEPSRKNATSLIL 1303
++ +E N K +E+ K+ +T K +++ +K V A+ K A L
Sbjct: 577 KKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARR--L 634
Query: 1304 FEEVDVIFDEDAGFLNAIKTFMATTKRPVIL 1334
E + V+ DE+ + T PVI+
Sbjct: 635 SESLHVV-DENKNESKLEREHKRRTSTPVIM 664
Score = 37.7 bits (86), Expect = 0.10
Identities = 44/203 (21%), Positives = 81/203 (39%), Gaps = 26/203 (12%)
Query: 574 LTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANL 633
L Q + + AS + S R S ++ S PTT+T S D + S+ A +K+
Sbjct: 211 LNQEASAARASTETSNAKTSERASKKLPSQPTTDT-----STDKERTSEDMADKEKSTAD 265
Query: 634 SEKHSLYTAELITVPFDSESPIR---------------MKFTRISTPKKSKKKSNKRSEK 678
S L TA D P+ K + + ++ K ++K +K
Sbjct: 266 SGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKK 325
Query: 679 SEATDGGFTSQIRKASNTSK-NISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTL 737
++ + G + +K K + SK + +K K ++ K E + +P ++S
Sbjct: 326 PDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSN---- 381
Query: 738 PERKKLSETEDSVIIIDSSPTAL 760
+ K + T++ +IDS L
Sbjct: 382 -KAKTVEGTKEDFSLIDSDVDGL 403
Score = 36.6 bits (83), Expect = 0.23
Identities = 97/504 (19%), Positives = 187/504 (37%), Gaps = 106/504 (21%)
Query: 67 RKTSPTNEK--TQLGKECK------IKSPESVPVDSNKDCTTPLEMFSNVEFKKKR---- 114
RK+ NE+ + LGK+ K IK+ E+V ++NK + E K +R
Sbjct: 789 RKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDS 848
Query: 115 --KRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDF-VESSTSVLRYKKQVEVLAEN 171
++ +L + + I + + E S+D + S N D ++ V + K++ + L E
Sbjct: 849 KIQKDSLGSKQHGITLQRRS--ESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEE 906
Query: 172 IQDTKSQPNTM--------TSLQN-------SKKVNPKQGTTKNDFKKLRKRKCRD---- 212
KS+ T T LQ + K + ++ T +ND +K RK K D
Sbjct: 907 KLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFE 966
Query: 213 ------VVDLSES--------------LPLAEELNLLKKDGKDT---------------- 236
V++ + S LPLA+E KD T
Sbjct: 967 ETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026
Query: 237 -------KQMENTTSHANSR--DNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTM 287
K+ EN + + + D+ E A+ N S++ L ++ + +
Sbjct: 1027 HSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ------ 1080
Query: 288 SICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQK 347
+E + + +S S + + + +T++ + P+ + +F K
Sbjct: 1081 ----EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSK 1136
Query: 348 QFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEA-GSSEAVKP------KCTLEER 400
+ N+ S + + K+K++ +Q++EL ++ ++ A KP E+
Sbjct: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKH 1196
Query: 401 QQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIM------ENSGIQM 454
+ +++ V K + +K+ + EV D + M EN +Q
Sbjct: 1197 ADHRSTLTKKMH--IQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQK 1254
Query: 455 VSKNGNLQLHTDKGSFLKEKNKKL 478
KN + H +G E + L
Sbjct: 1255 NLKNTAAEEHVAQGDATLEHSTNL 1278
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 66.2 bits (160), Expect = 3e-10
Identities = 204/1020 (20%), Positives = 408/1020 (40%), Gaps = 138/1020 (13%)
Query: 109 EFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVL 168
E + +K++N L N E +E + E N+ E S+ + +K ++ L
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 169 AENIQDTKSQPN------TMTSLQNSKKVN------PKQGTTKNDFKKLRKRKCRDVV-- 214
++ + + T LQ +++ + T ++ ++ K ++
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 215 -DLSES-LPLAEELNLLKKDGK---DTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEE 269
DL +S L EE+ +L ++ + + K++ T N + +TE + DS T++ E
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST-TLARIE 1327
Query: 270 FLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVH 329
+ K +E + S+ + + I ++ E ++ ++ + +R LA++
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEA---LEVKHDQLKEHIR----ETLAKIQ 1380
Query: 330 PIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSE 389
K+ + +K+K E +S E EQ K + + I+ E L L+ S +
Sbjct: 1381 ESQSKQEQSLN---MKEKDNETTKIVS--EMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 390 AVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEK------CLYEVGRDDN- 442
+K ++ Q ++ Q SD LK +K+ K + E+ CL E N
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 443 -----SKKIMENSGIQ--MVSKNGNLQ------------LHTDKGSFLKEKNKKLK--KK 481
S+K E S IQ + + N LQ + + S ++EK +LK K+
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 482 NKKTLDTG--AIPGKNREGNTQ----KKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFN 535
++K D+ +I K E + ++E +KEK+ R+ Q + + N
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV---QEALQIERDQLKEN 1612
Query: 536 NESLVYEDIANDD----LLKVSS-------LCNNNKLSRK--------TSIPVKDIKLTQ 576
+ +V + + + LK+++ +C L + +I ++I+LTQ
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQ 1672
Query: 577 SKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQ--LKASTQKAANLS 634
E+ + +V+ + RS ET++ ++ D +++N + + +K L
Sbjct: 1673 ILHENLEEMRSVTKERDDLRS-------VEETLK-VERDQLKENLRETITRDLEKQEELK 1724
Query: 635 EKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKA- 693
H T+ + K IS +K + SN + +A D ++R A
Sbjct: 1725 IVHMHLKEHQETID-KLRGIVSEKTNEISNMQKDLEHSN---DALKAQDLKIQEELRIAH 1780
Query: 694 ---SNTSKNISKAKQLIEKA--------KALHISRSKVTEEIAIPLRRSSRHQTLPERKK 742
+ I K + ++ + K L S +K+ E+I +++ HQ + +K
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE--LKANEHQLITLKKD 1838
Query: 743 LSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRK 802
++ET+ V ++ +K KL+ N L +KL+ + + + MK L R
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-NLRRV 1897
Query: 803 AQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMS----GLPDLLKRQIAKKAAAL- 857
+ ES Q+T K++D ++Q + K ++S D L+ +I++K +
Sbjct: 1898 EETLKLERDQLKESLQET--KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 858 DVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFS 917
D+ + S +Q+K + L+ LL +++N +++ +F
Sbjct: 1956 DIQKDLDKSKD---ELQKK-----IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFE 2007
Query: 918 TLNSKLKSGNSAAVFMRTRK--EFTEEVRNLLLEEIRWSNPEFSLK---KYFPLLLKKQI 972
N ++S F T+K E EE+R + E + SLK F L++ I
Sbjct: 2008 AQNLSMQSVRMDN-FQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMI 2066
Query: 973 EHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSK 1032
+ + ++ L +D T+ + K K+ +E + E NR S +L K
Sbjct: 2067 ARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK 2126
Score = 56.2 bits (134), Expect = 3e-07
Identities = 223/1141 (19%), Positives = 417/1141 (36%), Gaps = 222/1141 (19%)
Query: 107 NVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLN----------NDFVESST 156
+++F++K K V L + N+ + +S + K D SL + E +
Sbjct: 826 HMDFEQKYKMV-----LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR 880
Query: 157 SVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKK-VNPKQGTTKNDFKKLRKRKCRDVVD 215
V ++E L E +++ S T+ +++ K + K T + K L + K D+
Sbjct: 881 EVQERLNEMEQLKEQLENRDS---TLQTVEREKTLITEKLQQTLEEVKTLTQEK-DDLKQ 936
Query: 216 LSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHK 275
L ESL + E + LK D DT M N+ QL +++ E LK H+
Sbjct: 937 LQESLQI--ERDQLKSDIHDTVNM-----------NIDTQEQLRNAL------ESLKQHQ 977
Query: 276 ENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKK 335
E +I + E V E E + + K V +
Sbjct: 978 E-----------TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGID---------- 1016
Query: 336 TGKIPRIFLKQKQFEMENSLS----DPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAV 391
K++ E +N+ + +NE Q+RK +IQE+ +LE+ +E
Sbjct: 1017 ---------KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 392 KPKCTLEE--------------------RQQFMKAFRQ-----------PASDALKNGVK 420
+ K L+E +QQ + A + D L +
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 421 KSSDKQKDLNEK--CLYEVGRD--DNSKKIMENSGIQMVSKNGNLQL---HTDKGSFLKE 473
K +K + L EK L V + + KKI E ++ KN L L T++ ++
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 474 KNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTL 533
N+ ++ T + + + T++ +++E + Q K E +
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG----LQTKEELKIAHIH 1243
Query: 534 FNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKS 593
+++ K + + N L + + ++I + + E ++ VS +
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 594 TRRSGRI----SSTPTTETIRGIDSDDVQDNSQLKASTQKAANLS-EKHSLYT-AELITV 647
T + S+T + T+ I+ + ++ N + + S ++ +L+ E+ +L T E + V
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363
Query: 648 PFDS-ESPIRMKFTRISTPKKSKKKSNKRSEKSEATDG---------------------- 684
D + IR +I + +++S EK T
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 685 -GFTSQIRKASNTSKNISKAK---------------QLIEKAKALHISRSKVTEEIAIP- 727
G + +++++ + K+++K K QL E K + + EE+ +
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 728 LRRSSRHQTLPE-RKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTK 786
+ +T+ E R LSE E + I A+ +K Q K+Q ++ K+ + K
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAIN--DKLQNKIQ---EIYEKEEQFNIK 1538
Query: 787 NVPG-KMKVAPLFLVRKAQKAADPVPSFDES-----SQDTSEKSQDCDVQCKAKRDF--L 838
+ + KV L ++ +KA D ES + E ++ + K K + +
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1598
Query: 839 MSGLP---DLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCC-LWHLKPPSCPLLT 894
L D LK + A + F ++ V + + C + HLK
Sbjct: 1599 QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658
Query: 895 KFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWS 954
+ + T+ I L++ I + S K + T K ++++ L E I
Sbjct: 1659 NLENIETENIRLTQ--ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 955 NPEFSLKKYFPLLLKKQIE-----HQVLSSECHSKQELEADVSHKETKRK---------- 999
+ K + LK+ E ++S + + ++ D+ H K
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 1000 ------LVEAENS--------KSKRKKPNEYSKNLEKTNRKSEEL---SKRNNSSGIKL- 1041
L E + + K K + K+LE +N K +E K N I L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 1042 -----DSSKDSGTEDMLWTEKYQPQTASEL-IGNELAIKKLHSWLKDWKRRAELEERQNL 1095
K S E + K Q T S+L I N +KLH L++ K + ++ER NL
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK--SVMKERDNL 1894
Query: 1096 K 1096
+
Sbjct: 1895 R 1895
Score = 52.0 bits (123), Expect = 5e-06
Identities = 196/1047 (18%), Positives = 390/1047 (37%), Gaps = 176/1047 (16%)
Query: 109 EFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDY--SLNNDFVESSTSVLRYKKQVE 166
+ K+ K + H ++TE E + +E+ L + E T + +KQ+E
Sbjct: 1460 QLKENIKEIVAKH----LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515
Query: 167 VLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRK-RKCRDVVDLSESLPLAEE 225
+ + +Q+ + N K+++ Q N+ K+ ++ RK +D S + E
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKV-NELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 226 LNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDS 285
N L++ ++ + M V EA Q+ + + +E + KE++ +E
Sbjct: 1575 TNRLQESQEEIQIM---IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY--Q 1629
Query: 286 TMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTV---------LAQVHPIPPKK- 335
+ + +ET +++ + ++ E ++ +T + L ++ + ++
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689
Query: 336 -------TGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELEL--AVLEAG 386
T K+ R LK+ E D E ++ ++ ++ +E ++ ++
Sbjct: 1690 DLRSVEETLKVERDQLKENL--RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEK 1747
Query: 387 SSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKI 446
++E + LE +KA + L+ ++Q+ +++ R S+K
Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL------RGIVSEKT 1801
Query: 447 MENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETT 506
+ S +Q +N N +L +EK ++LK + + K TQKK +
Sbjct: 1802 DKLSNMQKDLENSNAKL--------QEKIQELKANEHQLITL-----KKDVNETQKKVSE 1848
Query: 507 FFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKT- 565
+KQ +++ SL K E E+L +++L ++ S+ R+
Sbjct: 1849 MEQLKKQIKDQ-SLTLSKLEI---------ENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
Query: 566 -SIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRG------IDSDDVQ 618
++ ++ +L +S E++A L + T R T + +R I D+Q
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ 1958
Query: 619 -DNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSE 677
D + K QK +K L +L+ V D + K + KK + N +
Sbjct: 1959 KDLDKSKDELQKKIQELQKKEL---QLLRVKEDVNMSHK-KINEMEQLKKQFEAQNLSMQ 2014
Query: 678 KSEATDGGFTSQIRKASNTSKNISKAKQLIEKAK-ALHISRSKVTEEIAIPLRRSSR-HQ 735
+ T ++ ++ + ++K + + + K +L + R + + + R + HQ
Sbjct: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Query: 736 TLPERKKLSE-----TEDSVIIIDSSPTALKHPEKNQKKLQCLNDV-------------- 776
PE++ LS+ TE LK + +CLN +
Sbjct: 2075 VKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKEL 2134
Query: 777 -LGKKLNTS-----TKNVPG-----------------KMKVAPLFLVRKAQKAADPVPSF 813
+ K N S TK++ K+K ++ + ++ + + F
Sbjct: 2135 SMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194
Query: 814 DESSQDTSEKS-----------QDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNA 862
+ D EK QDCDV + RD ++ DL +I K + + + +
Sbjct: 2195 EMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESE-FPS 2253
Query: 863 VSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKE--LNTKV-IDLSKCGIALGEFSTL 919
+ T FQ+V+ +++ +T+F E LNT+ I+ K GI
Sbjct: 2254 IKTEFQQVLSNRKE----------------MTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297
Query: 920 NSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSS 979
N M EF E + E W SLK+ L K +Q L +
Sbjct: 2298 QVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDLKSLKEKNEKLFK---NYQTLKT 2351
Query: 980 ECHSKQELEADVSHKE-----------TKRKLVEAENS--------KSKRKKPNEYSKNL 1020
S ++ + T K+ E ENS K K + K L
Sbjct: 2352 SLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411
Query: 1021 EKTNRKSEELSKRNNSSGIKLDSSKDS 1047
E TN +L + + S L+ +K++
Sbjct: 2412 EVTNDIIAKLQAKVHESNKCLEKTKET 2438
Score = 50.1 bits (118), Expect = 2e-05
Identities = 207/1101 (18%), Positives = 421/1101 (38%), Gaps = 180/1101 (16%)
Query: 58 KPSNILDYF----RKTSPTNEKTQLGKECKIKS----PESVPVDSNKDCTTPLEMFSNVE 109
K N LD F RKT E + + +K+ E D + ++ +E+ E
Sbjct: 529 KEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588
Query: 110 FKKKRKRVNL-SHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVL 168
+ K+ + + S +L NIK + +E S +D K+ + ++ T L K++ L
Sbjct: 589 DQIKKLQEYIDSQKLENIKMDLSYSLE-SIEDPKQ---MKQTLFDAETVALDAKRESAFL 644
Query: 169 -AENIQ---DTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLA- 223
+EN++ K T ++N ++ Q K KK++ VDL + L A
Sbjct: 645 RSENLELKEKMKELATTYKQMENDIQLYQSQLEAK---KKMQ-------VDLEKELQSAF 694
Query: 224 EELNLLKK--DGKDTKQM--------ENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKS 273
E+ L DGK K + + T V E L + +I +S + L S
Sbjct: 695 NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 274 HKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPP 333
E +EI D + + +I SE ++ +V K V + I
Sbjct: 755 EVERLRKEIQDKSEEL--------------HIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 334 KKTGKIPRIFLKQKQFEMENSLSDPENEQTVQ---KRKSNVVIQEEELELAVLEAGSSEA 390
K L Q +++ + +N +T+ ++K +V++E E + S EA
Sbjct: 801 TKDD------LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 391 VKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENS 450
K +L A + S + +K+ + Q+ LNE ME
Sbjct: 855 QKFDSSLG-------ALKTELSYKTQELQEKTREVQERLNE---------------MEQL 892
Query: 451 GIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLK 510
Q+ +++ LQ + + + EK ++ ++ KTL TQ+K+ LK
Sbjct: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEE-VKTL-------------TQEKDD---LK 935
Query: 511 EKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNN--NKLSRKTSIP 568
+ Q ++ Q K++ + + N ++ A + L + N +K+S + S
Sbjct: 936 QLQESLQIERDQLKSDIHDTVNM-NIDTQEQLRNALESLKQHQETINTLKSKISEEVS-- 992
Query: 569 VKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQ 628
+++ + ++ E++ ++ +T T DV+DN ++ +
Sbjct: 993 -RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA-------DVKDNEIIEQQRK 1044
Query: 629 KAANLSEKHSLYT------AELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEAT 682
+ + EK+ L AE + D + I M I ++ + ++ ++ E
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT---IENQEELRLLGDELKKQQEIV 1101
Query: 683 DGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKK 742
I+K S+ + ++ EK K +S+ +E + Q L +++
Sbjct: 1102 AQEKNHAIKKEGELSRTCDRLAEVEEKLK----EKSQQLQE--------KQQQLLNVQEE 1149
Query: 743 LSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRK 802
+SE + + I++ LK+ E + ++ L +KLN + + V K ++++
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK--VLKE 1207
Query: 803 AQKAADP--------VPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKA 854
QK+ + + + + T E+ + + K ++ + D L+R +++K
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI-----DELRRSVSEKT 1262
Query: 855 AALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALG 914
A + ++T H + +++ P+L + +EL V ++S+ +
Sbjct: 1263 AQI-----INTQDLEKSHTKLQEE-----------IPVLHEEQELLPNVKEVSETQETMN 1306
Query: 915 EFSTLNSKLKSGNSAAVF------MRTRKEF---TEEVRNLLLEEIRWSNPEFSLKKYFP 965
E L + + +S + +R ++F EE+++L E + +L+
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD 1366
Query: 966 LLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNR 1025
L + E E SKQE ++ K+ + + +E + K K +E
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGL 1426
Query: 1026 KSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQ-PQTASELIGNEL----AIKKLHSWL 1080
+ + + +++L +E Q + E++ L +K H L
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL 1486
Query: 1081 KDWKRRAELEERQNLKGKRDE 1101
K+ + E R NL K E
Sbjct: 1487 KEQEETIN-ELRVNLSEKETE 1506
Score = 48.5 bits (114), Expect = 6e-05
Identities = 141/660 (21%), Positives = 253/660 (38%), Gaps = 95/660 (14%)
Query: 500 TQKKETTFFLKEKQYQNRMSLRQRKT----------EFFKSSTLFNNESLVYEDIANDDL 549
T+K+E LKEK + +RKT E L + + +D+ N+
Sbjct: 519 TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578
Query: 550 LKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETI 609
KV L +K + KL K + SL ++ PK +++ + T +
Sbjct: 579 SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 638
Query: 610 RG---IDSDDVQDNSQLKASTQKAANLSEKHSLYTAELIT---VPFDSESPIRMKFTRIS 663
R + S++++ ++K + LY ++L + D E ++ F I+
Sbjct: 639 RESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT 698
Query: 664 ---------TPK-------------KSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNIS 701
PK +K+ NK E++EA S S+
Sbjct: 699 KLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVER 758
Query: 702 KAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALK 761
K++ +K++ LHI S+ + + + + SR Q L E ++ +T+D + S+ +
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE--EIGKTKDDLATTQSNYKSTD 816
Query: 762 HPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDES----S 817
+N K L D K +N +M + L ++AQK FD S
Sbjct: 817 QEFQNFKTLHM--DFEQKYKMVLEEN--ERMNQEIVNLSKEAQK-------FDSSLGALK 865
Query: 818 QDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVH----- 872
+ S K+Q+ + + ++ L + LK Q+ + + L T +
Sbjct: 866 TELSYKTQELQEKTREVQERLNE--MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 873 ----VQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNS 928
Q+KDD LK L + +L + + D I E L + L+S
Sbjct: 924 VKTLTQEKDD------LKQLQESLQIERDQLKSDIHDTVNMNIDTQE--QLRNALESLKQ 975
Query: 929 AAVFMRTRK-EFTEEV-RNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQE 986
+ T K + +EEV RNL +EE + +K + K+ + E + Q
Sbjct: 976 HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL-------EAKNTQT 1028
Query: 987 LEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKD 1046
L ADV E + + S ++ NE + LE + E+L + ++ + +
Sbjct: 1029 LTADVKDNEI---IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN---IEMTIE 1082
Query: 1047 SGTEDMLWTEKYQPQTASELIGNEL--AIKKLHSWLKDWKRRAELEERQNLKGKRDEKHE 1104
+ E L ++ + Q E++ E AIKK + R AE+EE+ LK K + E
Sbjct: 1083 NQEELRLLGDELKKQ--QEIVAQEKNHAIKKEGELSRTCDRLAEVEEK--LKEKSQQLQE 1138
Score = 32.7 bits (73), Expect = 3.4
Identities = 39/202 (19%), Positives = 77/202 (38%), Gaps = 13/202 (6%)
Query: 2 VGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSN 61
+ VL A P K+ EIE K + D K ++ + T+ V +
Sbjct: 2439 IQVLQDKVALGAKPYKE-EIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR 2497
Query: 62 ILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKD--CTTPLEMFSNVE-FKKKRKRVN 118
+L ++Q ++ + S + P SNK C + N + K + +
Sbjct: 2498 LL------RENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIR 2551
Query: 119 LSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQ 178
L +++ +K +NE I+ ++ + L+N+ L+ + +V EN +
Sbjct: 2552 LEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCEN---SPKS 2608
Query: 179 PNTMTSLQNSKKVNPKQGTTKN 200
P + K++ P Q +N
Sbjct: 2609 PKVTGTASKKKQITPSQCKERN 2630
>gi|27501458 CTF18, chromosome transmission fidelity factor 18 homolog
[Homo sapiens]
Length = 975
Score = 58.2 bits (139), Expect = 7e-08
Identities = 54/251 (21%), Positives = 102/251 (40%), Gaps = 21/251 (8%)
Query: 998 RKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEK 1057
+K V+ E + ++ + S L EE ++ + + +D+ + LW ++
Sbjct: 227 KKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSH-CLWVDE 285
Query: 1058 YQPQTASELIGNELAIKKLHSWLKDWK------RRAELEERQNLKGKRDEKHEDFSGGI- 1110
+ P+ +EL+ ++ + L WLK W R + R +++ R K G
Sbjct: 286 FAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEATAPGKWK 345
Query: 1111 -------DFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRS 1163
+ + D + L+ GP G+GKT + A+ G+ + E+NAS RS
Sbjct: 346 SHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRS 405
Query: 1164 GRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVT--SPRKVPP- 1220
++++ ATQ V G + C G I+ ++ P++V P
Sbjct: 406 PEVFRTRIEAATQMESV--LGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGPQEVGPQ 463
Query: 1221 -PSPKSSGPKR 1230
P+ S G +R
Sbjct: 464 GPAVPSGGGRR 474
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.6 bits (135), Expect = 2e-07
Identities = 197/1042 (18%), Positives = 411/1042 (39%), Gaps = 149/1042 (14%)
Query: 103 EMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDF-VESSTSVLRY 161
++ S VE +++R ++ L N K + +A I+ + E+ +E T+ +
Sbjct: 926 DLESRVEEEEERNQI-----LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980
Query: 162 KK-QVEVLAENIQDTK--SQPNTMTS--LQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDL 216
KK + E+L Q++K + M + S ++ ++ KN K+R ++ + DL
Sbjct: 981 KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN-LAKIRNKQEVMISDL 1039
Query: 217 SESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEA-AQLNDSIITVSY-EEFLKS- 273
E L E+ + K E T + +D + E AQ+++ + ++ EE L+
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETT----DLQDQIAELQAQIDELKLQLAKKEEELQGA 1095
Query: 274 ---------HKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRF----- 319
HK N ++ + + I E + S +E + ++S+++
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
Query: 320 -KTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEEL 378
T+ A + K+ ++ + +K E E + + + Q+ + + E+L
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAEL---KKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 379 ELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALK--NGVKKSSDKQKDLNEKCLYE 436
E +A + K LE+ +Q ++ + + +K VK S+ ++ + + E
Sbjct: 1213 E---------QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 437 VGRDDNSKKIMENSG--IQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGK 494
+ K+ E +++ K LQ D S L E+ +K K K D ++
Sbjct: 1264 L-----HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASL--- 1313
Query: 495 NREGNTQKKETTFFLKEKQYQN-RMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVS 553
+Q ++T L+E+ Q +S R R+ E K+S E E+ A +L K
Sbjct: 1314 ----ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE---EEEARKNLEKQV 1366
Query: 554 SLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGID 613
+ K + D+ +S E++ LL + S R + + E +
Sbjct: 1367 LALQSQLADTKKKVD-DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 614 SDDVQDNS-QLKASTQKAANLSEKHSLY----------TAELITVPFDSESPIRMKFTRI 662
++ D + L Q A+NL +K + +A +E+ R K T+
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 663 STPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKA-----LHISR 717
+ ++ +++ + E+ E + + + ++ ++ K +EK+K + R
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 718 SKVTE---------------EIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKH 762
+++ E E+ + ++ + L R + +E + ++I L+
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI--KQVRELEA 1603
Query: 763 PEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSE 822
++++K + L KK+ K++ +++ A KA D V Q +
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIEAA--------NKARDEVIKQLRKLQAQMK 1655
Query: 823 KSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCC- 881
Q + +A RD + + + K+ + +A L + +++S + H +Q+ D
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 882 -LWHLKPPSCPLLTKFKELNTKVIDL--------SKCGIALGEF-------STLNSKLKS 925
+ + LL + + L ++ L S + F TLN++L +
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775
Query: 926 GNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKK------QIEHQVLSS 979
SAA ++ E L +++ E ++K F + Q+E Q+
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQ--ELEGAVKSKFKATISALEAKIGQLEEQL--- 1830
Query: 980 ECHSKQELEADVSHKETKRKLVE-----------AENSKSKRKKPNEYSKNLEKTNRKSE 1028
E +K+ A+ + T++KL E A+ K + +K N K L++ ++E
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 1029 ELSKRNNSSGIKLDSSKDSGTE 1050
E + R N+S KL D TE
Sbjct: 1891 EEATRANASRRKLQRELDDATE 1912
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 55.5 bits (132), Expect = 5e-07
Identities = 110/590 (18%), Positives = 244/590 (41%), Gaps = 85/590 (14%)
Query: 201 DFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLND 260
DF K ++ ++ E + + E+ L +K K+ ++N + D + + + N+
Sbjct: 832 DFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKN--EYEGKLDGLIKETEENE 889
Query: 261 SIIT------VSYEEFLKSHKENKVEEIP-DSTMSICVPSETVDEIVKSGYISESENSEI 313
+ I V EE L++ K+N+ + + IC+ +E ++++ I S+N EI
Sbjct: 890 NKIKKLKGELVCLEEVLQN-KDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEI 948
Query: 314 SQQVRFKTVTV--LAQVHPIPPKKTG-------KIPRIFLKQKQF--------EMENSLS 356
+ + + + + L ++H +K + + LK+ + E E ++
Sbjct: 949 KELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMT 1008
Query: 357 D---------PENEQTVQKRKSN--VVIQEEELELAVLEAGSSEAVKPKCTLE------- 398
D EN+Q + + + + +IQE+E +L L+ S+ +C LE
Sbjct: 1009 DHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKE 1068
Query: 399 ---------------ERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNS 443
++++ +K+ + ++ L+ + K + K +D NE Y+VG +
Sbjct: 1069 AETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNEN--YQVGLAE-L 1125
Query: 444 KKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKK 503
+ +M Q +S+ + H ++ + LK + K+ + + + + K
Sbjct: 1126 RTLMTIEKDQCISE--LISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183
Query: 504 ETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSR 563
++ E+Q +++ ++ K E + + + LV + + L C ++ +
Sbjct: 1184 DSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQ 1243
Query: 564 KTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQL 623
+K+ KL + E E K +I+ +P ++ RG DS + Q
Sbjct: 1244 TA---LKEFKLEREVVEKEL------LEKVKHLENQIAKSPAIDSTRG-DSSSLVAELQE 1293
Query: 624 KASTQKA---ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKS--NKRSEK 678
K +KA L E+ E+ V + + F + T +K +K++ N S+K
Sbjct: 1294 KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
Query: 679 SEATDGGFTSQIRKASNTSKNISKAK-QLIEKAKALHISRSKVTEEIAIP 727
++T Q + + +++S+ + +L+E+ K L SK+ +P
Sbjct: 1354 LKST----MQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVP 1399
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 55.5 bits (132), Expect = 5e-07
Identities = 110/590 (18%), Positives = 244/590 (41%), Gaps = 85/590 (14%)
Query: 201 DFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLND 260
DF K ++ ++ E + + E+ L +K K+ ++N + D + + + N+
Sbjct: 832 DFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKN--EYEGKLDGLIKETEENE 889
Query: 261 SIIT------VSYEEFLKSHKENKVEEIP-DSTMSICVPSETVDEIVKSGYISESENSEI 313
+ I V EE L++ K+N+ + + IC+ +E ++++ I S+N EI
Sbjct: 890 NKIKKLKGELVCLEEVLQN-KDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEI 948
Query: 314 SQQVRFKTVTV--LAQVHPIPPKKTG-------KIPRIFLKQKQF--------EMENSLS 356
+ + + + + L ++H +K + + LK+ + E E ++
Sbjct: 949 KELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMT 1008
Query: 357 D---------PENEQTVQKRKSN--VVIQEEELELAVLEAGSSEAVKPKCTLE------- 398
D EN+Q + + + + +IQE+E +L L+ S+ +C LE
Sbjct: 1009 DHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKE 1068
Query: 399 ---------------ERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNS 443
++++ +K+ + ++ L+ + K + K +D NE Y+VG +
Sbjct: 1069 AETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNEN--YQVGLAE-L 1125
Query: 444 KKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKK 503
+ +M Q +S+ + H ++ + LK + K+ + + + + K
Sbjct: 1126 RTLMTIEKDQCISE--LISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183
Query: 504 ETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSR 563
++ E+Q +++ ++ K E + + + LV + + L C ++ +
Sbjct: 1184 DSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQ 1243
Query: 564 KTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQL 623
+K+ KL + E E K +I+ +P ++ RG DS + Q
Sbjct: 1244 TA---LKEFKLEREVVEKEL------LEKVKHLENQIAKSPAIDSTRG-DSSSLVAELQE 1293
Query: 624 KASTQKA---ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKS--NKRSEK 678
K +KA L E+ E+ V + + F + T +K +K++ N S+K
Sbjct: 1294 KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
Query: 679 SEATDGGFTSQIRKASNTSKNISKAK-QLIEKAKALHISRSKVTEEIAIP 727
++T Q + + +++S+ + +L+E+ K L SK+ +P
Sbjct: 1354 LKST----MQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVP 1399
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 55.1 bits (131), Expect = 6e-07
Identities = 161/786 (20%), Positives = 289/786 (36%), Gaps = 118/786 (15%)
Query: 25 KKRKKDDDTSTCKTITKYLSPLGKTRD----RVFAPPKPSNILDYFRKTSPTNEKTQLGK 80
+K K++ T T+ L KTR+ R PK L F ++ + K
Sbjct: 468 EKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK----H 523
Query: 81 ECKIKSPESVPV--DSNKDCTTP----------LEMFSNVE---------FKKKRKRVNL 119
C + +S P+ + K C +P L + N E K + +
Sbjct: 524 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 583
Query: 120 SHQLN-----------NIKTENEAPIEISSDDS-----KEDYSLNNDFVE-SSTSVLRYK 162
HQ + IK E+ +P +SD + KE +L ++ ++K
Sbjct: 584 KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHK 643
Query: 163 KQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPL 222
K++E E + S S++ ++ K +F K + + + ESL L
Sbjct: 644 KEIEGEKEKYKTKDSAKELQRSVEFDREF------WKENFFKSDETEDLFLNMEHESLTL 697
Query: 223 AEELNLLK--KDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVE 280
++ L K KD K TK+ H + N E D I +E KS +E K++
Sbjct: 698 EKKSKLEKNIKDDKSTKE-----KHVSKERNFKEE---RDKI----KKESEKSFREEKIK 745
Query: 281 EIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIP 340
++ + +I P++ E G + E+ I + K + + Q I K
Sbjct: 746 DLKEERENI--PTDKDSEFTSLGMSAIEES--IGLHLVEKEIDIEKQEKHIKESKEKPEK 801
Query: 341 RIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVK------PK 394
R +K+K E + + ++ + KS ++++L+L+ E K K
Sbjct: 802 RSQIKEKDIEKMERKTFEKEKKIKHEHKS----EKDKLDLSECVDKIKEKDKLYSHHTEK 857
Query: 395 CTLEERQQFMKAFRQPASDALKNGVK--KSSDKQKDLNEKCLYEVGRDDNSKKIMENSGI 452
C E + A + D K+ K + DK+K E+ L E K +ME
Sbjct: 858 CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE----SKEKHLMEKKNK 913
Query: 453 QMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEK 512
Q + N + + KEK+++L KK K ++ +KK + +
Sbjct: 914 Q----SDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 969
Query: 513 QYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDI 572
Q++ +SL+++ + E L D D + K I + +
Sbjct: 970 QHEKPLSLKEKTKD----------EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSL 1019
Query: 573 KLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETI--RGIDSDDVQDNSQLKASTQKA 630
+S+A+ + ++ + + R+ + +T R + D++ K +K
Sbjct: 1020 LKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI 1079
Query: 631 ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQI 690
EK L + E I+ K TP +SK K RS+ SE TD
Sbjct: 1080 KQ-KEKERLRNRNCL------ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA-----Y 1127
Query: 691 RKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSV 750
K +S Q ++ + + +S + + L RS R + E+ LS S+
Sbjct: 1128 TKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNS--LNRSPRSEN--EKPGLSSRSVSM 1183
Query: 751 IIIDSS 756
I + SS
Sbjct: 1184 ISVASS 1189
Score = 45.8 bits (107), Expect = 4e-04
Identities = 185/990 (18%), Positives = 360/990 (36%), Gaps = 172/990 (17%)
Query: 131 EAPIEISSDDS-----KEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSL 185
E P++++ + K + L++D + S + ENI D++++ +++ +
Sbjct: 262 ERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENI-DSETEKDSL--I 318
Query: 186 QNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSH 245
SK++ P + + + + D E + ++ ++L+K+ + + E +H
Sbjct: 319 CESKQILPSKTPLPSALDEYEFKDDDD----EEINKMIDDRHILRKEQRKENEPEAEKTH 374
Query: 246 ANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKS-GY 304
++ Y + KS K+ + ST S + +I S
Sbjct: 375 LFAKQE------------KAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 422
Query: 305 ISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTV 364
I E+ NS++ + + V++ H K+ GK+ R LK + EN E E
Sbjct: 423 IPETSNSDMQTKKEY----VVSGEH----KQKGKVKRK-LKNQNKNKENQELKQEKEGKE 473
Query: 365 QKRKSNVVIQ---------------------EEELELAVLEAGSSEAVKPKCTLEERQ-- 401
R +N+ + +++ L + + ++ K C L E+Q
Sbjct: 474 NTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 533
Query: 402 ----QFMKAFRQPASDALK---NGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQM 454
+ K P S + + V+ + + + L E + + K ++ ++
Sbjct: 534 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 593
Query: 455 VSKNGNLQLHTDKGSFLKEKNKKLKKKNK--KTLDTGAIPGKNREGNTQKKETTFFLKEK 512
K+ D + + LKK +K KTL + K RE KKE +++
Sbjct: 594 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEG--EKE 651
Query: 513 QYQNRMSLR--QRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVK 570
+Y+ + S + QR EF + F E+ D D L + + K +K
Sbjct: 652 KYKTKDSAKELQRSVEFDRE---FWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 708
Query: 571 DIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKA 630
D K T+ K +VS ++ + + D ++ S+ +K
Sbjct: 709 DDKSTKEK--------HVSKERNFKE----------------ERDKIKKESEKSFREEKI 744
Query: 631 ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQI 690
+L E+ I T K S+ S S E+ +
Sbjct: 745 KDLKEERE----------------------NIPTDKDSEFTSLGMSAIEESIGLHLVEKE 782
Query: 691 RKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSV 750
K+I ++K+ EK + + E + +H+ E+ KL +E
Sbjct: 783 IDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD 842
Query: 751 IIIDSSPTALKHPEKNQKKLQ-CLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADP 809
I + H EK K+ + N KK + K+ + K+ K +K
Sbjct: 843 KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKS---REKMDRKHDKEKPEKERHL 899
Query: 810 VPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQR 869
S ++ + K D K+++ +L K++ ++ ++++ N+
Sbjct: 900 AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK------ 953
Query: 870 VVHVQQKD-----DGCCLWHLKPPSCPLLTKFKELNT----------KVIDLSKCGIALG 914
H+Q++ DG H KP S TK + L T K ID K
Sbjct: 954 --HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1011
Query: 915 EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEH 974
+ +NS LK + A + + + + ++ +E R N + L++ E
Sbjct: 1012 DKIQINSLLKLKSEAD---KPKPKSSPASKDTRPKEKRLVNDD---------LMQTSFER 1059
Query: 975 QVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYS-KNLEKTNRKSEELSKR 1033
+ S ++LE + HK+ K K+ + E + + + E K+ EKT E
Sbjct: 1060 ML------SLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE---- 1109
Query: 1034 NNSSGIKLDSSKDSGTEDMLWTEKYQPQTA 1063
S +L SK S D +T++ QP+ A
Sbjct: 1110 --SKNKELTRSKSSEVTD-AYTKEKQPKDA 1136
Score = 31.2 bits (69), Expect = 9.8
Identities = 33/151 (21%), Positives = 63/151 (41%), Gaps = 11/151 (7%)
Query: 973 EHQVLSSECHSKQELEADVSHKETKR-KLVEAENSKSKRKKPNEYSKNLEKTNRKSEELS 1031
+ +L E + E EA+ +H K+ K ++ KSK++KP S+ L + S+E +
Sbjct: 354 DRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKP---SRVLYSSTESSDEEA 410
Query: 1032 KRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEE 1091
+N ++ DM ++Y + G K+ LK+ + E +E
Sbjct: 411 LQNKKISTSCSVIPETSNSDMQTKKEY------VVSGEHKQKGKVKRKLKNQNKNKENQE 464
Query: 1092 -RQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
+Q +GK + + + + S EE
Sbjct: 465 LKQEKEGKENTRITNLTVNTGLDCSEKTREE 495
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 55.1 bits (131), Expect = 6e-07
Identities = 161/786 (20%), Positives = 289/786 (36%), Gaps = 118/786 (15%)
Query: 25 KKRKKDDDTSTCKTITKYLSPLGKTRD----RVFAPPKPSNILDYFRKTSPTNEKTQLGK 80
+K K++ T T+ L KTR+ R PK L F ++ + K
Sbjct: 491 EKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPK----H 546
Query: 81 ECKIKSPESVPV--DSNKDCTTP----------LEMFSNVE---------FKKKRKRVNL 119
C + +S P+ + K C +P L + N E K + +
Sbjct: 547 SCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKS 606
Query: 120 SHQLN-----------NIKTENEAPIEISSDDS-----KEDYSLNNDFVE-SSTSVLRYK 162
HQ + IK E+ +P +SD + KE +L ++ ++K
Sbjct: 607 KHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHK 666
Query: 163 KQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPL 222
K++E E + S S++ ++ K +F K + + + ESL L
Sbjct: 667 KEIEGEKEKYKTKDSAKELQRSVEFDREF------WKENFFKSDETEDLFLNMEHESLTL 720
Query: 223 AEELNLLK--KDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVE 280
++ L K KD K TK+ H + N E D I +E KS +E K++
Sbjct: 721 EKKSKLEKNIKDDKSTKE-----KHVSKERNFKEE---RDKI----KKESEKSFREEKIK 768
Query: 281 EIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIP 340
++ + +I P++ E G + E+ I + K + + Q I K
Sbjct: 769 DLKEERENI--PTDKDSEFTSLGMSAIEES--IGLHLVEKEIDIEKQEKHIKESKEKPEK 824
Query: 341 RIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVK------PK 394
R +K+K E + + ++ + KS ++++L+L+ E K K
Sbjct: 825 RSQIKEKDIEKMERKTFEKEKKIKHEHKS----EKDKLDLSECVDKIKEKDKLYSHHTEK 880
Query: 395 CTLEERQQFMKAFRQPASDALKNGVK--KSSDKQKDLNEKCLYEVGRDDNSKKIMENSGI 452
C E + A + D K+ K + DK+K E+ L E K +ME
Sbjct: 881 CHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAE----SKEKHLMEKKNK 936
Query: 453 QMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEK 512
Q + N + + KEK+++L KK K ++ +KK + +
Sbjct: 937 Q----SDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKA 992
Query: 513 QYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDI 572
Q++ +SL+++ + E L D D + K I + +
Sbjct: 993 QHEKPLSLKEKTKD----------EPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSL 1042
Query: 573 KLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETI--RGIDSDDVQDNSQLKASTQKA 630
+S+A+ + ++ + + R+ + +T R + D++ K +K
Sbjct: 1043 LKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI 1102
Query: 631 ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQI 690
EK L + E I+ K TP +SK K RS+ SE TD
Sbjct: 1103 KQ-KEKERLRNRNCL------ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDA-----Y 1150
Query: 691 RKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSV 750
K +S Q ++ + + +S + + L RS R + E+ LS S+
Sbjct: 1151 TKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNS--LNRSPRSEN--EKPGLSSRSVSM 1206
Query: 751 IIIDSS 756
I + SS
Sbjct: 1207 ISVASS 1212
Score = 45.8 bits (107), Expect = 4e-04
Identities = 185/990 (18%), Positives = 360/990 (36%), Gaps = 172/990 (17%)
Query: 131 EAPIEISSDDS-----KEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSL 185
E P++++ + K + L++D + S + ENI D++++ +++ +
Sbjct: 285 ERPVDVAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENI-DSETEKDSL--I 341
Query: 186 QNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSH 245
SK++ P + + + + D E + ++ ++L+K+ + + E +H
Sbjct: 342 CESKQILPSKTPLPSALDEYEFKDDDD----EEINKMIDDRHILRKEQRKENEPEAEKTH 397
Query: 246 ANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKS-GY 304
++ Y + KS K+ + ST S + +I S
Sbjct: 398 LFAKQE------------KAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
Query: 305 ISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTV 364
I E+ NS++ + + V++ H K+ GK+ R LK + EN E E
Sbjct: 446 IPETSNSDMQTKKEY----VVSGEH----KQKGKVKRK-LKNQNKNKENQELKQEKEGKE 496
Query: 365 QKRKSNVVIQ---------------------EEELELAVLEAGSSEAVKPKCTLEERQ-- 401
R +N+ + +++ L + + ++ K C L E+Q
Sbjct: 497 NTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQST 556
Query: 402 ----QFMKAFRQPASDALK---NGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQM 454
+ K P S + + V+ + + + L E + + K ++ ++
Sbjct: 557 PLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEF 616
Query: 455 VSKNGNLQLHTDKGSFLKEKNKKLKKKNK--KTLDTGAIPGKNREGNTQKKETTFFLKEK 512
K+ D + + LKK +K KTL + K RE KKE +++
Sbjct: 617 GEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEG--EKE 674
Query: 513 QYQNRMSLR--QRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVK 570
+Y+ + S + QR EF + F E+ D D L + + K +K
Sbjct: 675 KYKTKDSAKELQRSVEFDRE---FWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
Query: 571 DIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKA 630
D K T+ K +VS ++ + + D ++ S+ +K
Sbjct: 732 DDKSTKEK--------HVSKERNFKE----------------ERDKIKKESEKSFREEKI 767
Query: 631 ANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQI 690
+L E+ I T K S+ S S E+ +
Sbjct: 768 KDLKEERE----------------------NIPTDKDSEFTSLGMSAIEESIGLHLVEKE 805
Query: 691 RKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSV 750
K+I ++K+ EK + + E + +H+ E+ KL +E
Sbjct: 806 IDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVD 865
Query: 751 IIIDSSPTALKHPEKNQKKLQ-CLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADP 809
I + H EK K+ + N KK + K+ + K+ K +K
Sbjct: 866 KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKS---REKMDRKHDKEKPEKERHL 922
Query: 810 VPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQR 869
S ++ + K D K+++ +L K++ ++ ++++ N+
Sbjct: 923 AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK------ 976
Query: 870 VVHVQQKD-----DGCCLWHLKPPSCPLLTKFKELNT----------KVIDLSKCGIALG 914
H+Q++ DG H KP S TK + L T K ID K
Sbjct: 977 --HIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1034
Query: 915 EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEH 974
+ +NS LK + A + + + + ++ +E R N + L++ E
Sbjct: 1035 DKIQINSLLKLKSEAD---KPKPKSSPASKDTRPKEKRLVNDD---------LMQTSFER 1082
Query: 975 QVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYS-KNLEKTNRKSEELSKR 1033
+ S ++LE + HK+ K K+ + E + + + E K+ EKT E
Sbjct: 1083 ML------SLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE---- 1132
Query: 1034 NNSSGIKLDSSKDSGTEDMLWTEKYQPQTA 1063
S +L SK S D +T++ QP+ A
Sbjct: 1133 --SKNKELTRSKSSEVTD-AYTKEKQPKDA 1159
Score = 31.2 bits (69), Expect = 9.8
Identities = 33/151 (21%), Positives = 63/151 (41%), Gaps = 11/151 (7%)
Query: 973 EHQVLSSECHSKQELEADVSHKETKR-KLVEAENSKSKRKKPNEYSKNLEKTNRKSEELS 1031
+ +L E + E EA+ +H K+ K ++ KSK++KP S+ L + S+E +
Sbjct: 377 DRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKP---SRVLYSSTESSDEEA 433
Query: 1032 KRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEE 1091
+N ++ DM ++Y + G K+ LK+ + E +E
Sbjct: 434 LQNKKISTSCSVIPETSNSDMQTKKEY------VVSGEHKQKGKVKRKLKNQNKNKENQE 487
Query: 1092 -RQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
+Q +GK + + + + S EE
Sbjct: 488 LKQEKEGKENTRITNLTVNTGLDCSEKTREE 518
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 53.5 bits (127), Expect = 2e-06
Identities = 182/943 (19%), Positives = 379/943 (40%), Gaps = 161/943 (17%)
Query: 111 KKKRKRVNLSHQLNN--IKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVL 168
K ++ +QL +K ENE + S ++ L N+ + + + +++E +
Sbjct: 75 KAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDM 134
Query: 169 AENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRK---CRDVVDLSESLPLAEE 225
+ ++ K + N +L+N + N + + + K+L+K+ C+D++D + + +E
Sbjct: 135 EKELEKEK-KVNEQLALRNEEAEN-ENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKE 192
Query: 226 LNLLKKDGKD-------TKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKEN- 277
LL + G+D +K+ + + +TEA + I V +E K+ +E+
Sbjct: 193 -TLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEA----NEKIEVQNQEMRKNLEESV 247
Query: 278 -KVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKT 336
++E++ D + D ++ + EN QV+ T + ++ P
Sbjct: 248 QEMEKMTDEYNRMKAIVHQTDNVIDQ---LKKENDHYQLQVQELTDLLKSKNEEDDPIMV 304
Query: 337 GKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCT 396
+ K +++++ S D E + Q+ N+ E+L+ A L+A S + +
Sbjct: 305 A----VNAKVEEWKLILSSKDDEIIE-YQQMLHNL---REKLKNAQLDADKSNVMALQQG 356
Query: 397 LEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVS 456
++ER +K + K K + C+ E D ++ N G +S
Sbjct: 357 IQERDSQIKMLTEQVEQYTKEMEKNT----------CIIE----DLKNELQRNKGASTLS 402
Query: 457 KNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQN 516
+ ++++ + LKEK K+ ++T + + ++ KE LK
Sbjct: 403 QQTHMKIQSTL-DILKEKTKEA----ERTAELAEADAREKD-----KELVEALKR----- 447
Query: 517 RMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKL-SRKTSIPVKDIKLT 575
L + ES VY D ++++ + N K+ R+ I K+I
Sbjct: 448 ----------------LKDYESGVYG--LEDAVVEIKNCKNQIKIRDREIEILTKEINKL 489
Query: 576 QSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSE 635
+ K ++ ++ R+ P T ID + +++ LK +A N
Sbjct: 490 ELK-------ISDFLDENEALRERVGLEPKTM----IDLTEFRNSKHLKQQQYRAEN--- 535
Query: 636 KHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASN 695
+++ +S ++ R+ KK ++ + +R ++S AT G T + N
Sbjct: 536 -------QILLKEIES-----LEEERLDLKKKIRQMAQERGKRS-ATSGLTTEDL----N 578
Query: 696 TSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDS 755
++NIS+ ++ E+ L +S ++E S+++ L R+ + + D ++
Sbjct: 579 LTENISQGDRISERKLDL-LSLKNMSE-------AQSKNEFL-SRELIEKERD----LER 625
Query: 756 SPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDE 815
S T + K Q KL+ L + K+L K + +K K + + +PS +
Sbjct: 626 SRTVI---AKFQNKLKELVEE-NKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER 681
Query: 816 SSQDTSEKSQ----DCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVV 871
K+ D + KA+ D L +L + + A++ ++ + ++
Sbjct: 682 LVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKID 741
Query: 872 HVQQKDDGCCLWHLKPPSCPLLTKFKELNT--KVIDLSKCGIALGEFSTLNSKLKSGNSA 929
H++++ LL + + N K IDL GIA S +NS+ N
Sbjct: 742 HLEKETS-------------LLRQSEGSNVVFKGIDLPD-GIAPSSASIINSQ----NEY 783
Query: 930 AVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEA 989
+ + E E+ L + + N +F++ ++ LL K+ + + + SK
Sbjct: 784 LIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESK----- 838
Query: 990 DVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSK 1032
+ KE KRKL + + + K EY+ L S+E+ K
Sbjct: 839 --TIKEEKRKLEDQVQQDAIKVK--EYNNLLNALQMDSDEMKK 877
Score = 41.2 bits (95), Expect = 0.009
Identities = 156/826 (18%), Positives = 302/826 (36%), Gaps = 125/826 (15%)
Query: 338 KIPRIFLKQKQFEMENSLSDPENEQTVQKR-----KSNVVIQEEELELAVLEAGSSEAVK 392
+I + +K K E+E +L + E Q + K+ V+ E ELE+A AG +
Sbjct: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDT-- 110
Query: 393 PKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLY--EVGRDDNSKKIMENS 450
+ E Q K Q D ++K +K+K +NE+ E ++NSK
Sbjct: 111 -RFLRNEICQLEKQLEQ--KDRELEDMEKELEKEKKVNEQLALRNEEAENENSK------ 161
Query: 451 GIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKN----------KKTLDTGAIPGKNREGNT 500
L+ +NK+LKKKN +K +D+ +R G
Sbjct: 162 --------------------LRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGED 201
Query: 501 QKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNK 560
+ K + + Q TE + + N E + + ++ K++ N
Sbjct: 202 SDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNR-- 259
Query: 561 LSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRG--------I 612
K + D + Q K E++ L V +S P + +
Sbjct: 260 --MKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLIL 317
Query: 613 DSDDVQDNSQLKASTQKAANLSE--KHSLYTAELITVPFDSESPIRMKFTRISTPKKSKK 670
S D ++ Q NL E K++ A+ V + I+ + ++I + +
Sbjct: 318 SSKD----DEIIEYQQMLHNLREKLKNAQLDADKSNV-MALQQGIQERDSQIKMLTEQVE 372
Query: 671 KSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTE---EIAIP 727
+ K EK+ +++++ S + I+ + ++K E E+A
Sbjct: 373 QYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEA 432
Query: 728 LRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLN-DVLGKKLNTSTK 786
R + + K+L + E V ++ + +K+ KNQ K++ ++L K++N
Sbjct: 433 DAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNC-KNQIKIRDREIEILTKEINKL-- 489
Query: 787 NVPGKMKVAPLFLVRKAQK---AADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLP 843
++K++ +A + +P D + S+ + Q +A+ L+ +
Sbjct: 490 ----ELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLK--QQQYRAENQILLKEIE 543
Query: 844 DL------LKRQIAKKAAALDVYNAVSTSFQRVVHV-----------QQKDDGCCLWHLK 886
L LK++I + A +A S +++ ++K D L ++
Sbjct: 544 SLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMS 603
Query: 887 PPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNL 946
+EL K DL + + +F +L N KE + ++ +
Sbjct: 604 EAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQ--LEEGMKEILQAIKEM 661
Query: 947 LLE-EIRWSNPEF---SLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVE 1002
+ +++ SL++ + K E + + H K +++ E R
Sbjct: 662 QKDPDVKGGETSLIIPSLERLVNAIESKNAE-GIFDASLHLKAQVDQLTGRNEELR---- 716
Query: 1003 AENSKSKRKKPNEYSKNLEKTNRKSEELSKRNN-----------SSGIKL-DSSKDSGTE 1050
+ + RK+ YS+ L K N K + L K + GI L D S
Sbjct: 717 -QELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSAS 775
Query: 1051 DMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRR-AELEERQNL 1095
+ +Y EL E +K L L+D+ R+ A + +Q+L
Sbjct: 776 IINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSL 821
>gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 51.2 bits (121), Expect = 9e-06
Identities = 101/471 (21%), Positives = 186/471 (39%), Gaps = 69/471 (14%)
Query: 616 DVQDNSQLKASTQKAAN----------LSEKHSLYTAELITVPFDSESPIRMKFTRISTP 665
++ +N ++K S+Q+AA + EK + + E + + K I+TP
Sbjct: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTP 142
Query: 666 KKSKKKSNKRSEKS-EATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEI 724
K +++ +++EK E + G + + N + + + E+
Sbjct: 143 KAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRP--------------AATEV 188
Query: 725 AIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTS 784
IP R P+ K +S II + + K E+ Q K Q D G+K
Sbjct: 189 KIPKPRGR-----PKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDK 243
Query: 785 TKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPD 844
+ P K + ++ A V S +S ++ + Q+ + + K R+F + +
Sbjct: 244 PRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDD--QEGEKKRKGGRNFQTAHRRN 301
Query: 845 LLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKE------ 898
+LK Q K+AA Q Q KD+G K P + K +E
Sbjct: 302 MLKGQHEKEAAD----RKRKQEEQMETEQQNKDEG------KKPEVKKVEKKRETSMDSR 351
Query: 899 -----------LNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTE-EVRNL 946
L +D+++C AL E ++L ++ + T K+ +V +
Sbjct: 352 LQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQV 411
Query: 947 LLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLS-SECHSKQELEADVSHKETKR---KLVE 1002
++E+ +F K F + + QVL+ S +Q EA+ + + K+ K +E
Sbjct: 412 IMEKSTMLYNKF--KNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLE 469
Query: 1003 AENSKSKRKKPNEYSK--NLEKTNRKSEELSKRNN-SSGIKLDSSKDSGTE 1050
E + SK ++ N + N +S E SK N+ +S K SS++ TE
Sbjct: 470 KEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
>gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 51.2 bits (121), Expect = 9e-06
Identities = 101/471 (21%), Positives = 186/471 (39%), Gaps = 69/471 (14%)
Query: 616 DVQDNSQLKASTQKAAN----------LSEKHSLYTAELITVPFDSESPIRMKFTRISTP 665
++ +N ++K S+Q+AA + EK + + E + + K I+TP
Sbjct: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTP 142
Query: 666 KKSKKKSNKRSEKS-EATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEI 724
K +++ +++EK E + G + + N + + + E+
Sbjct: 143 KAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRP--------------AATEV 188
Query: 725 AIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTS 784
IP R P+ K +S II + + K E+ Q K Q D G+K
Sbjct: 189 KIPKPRGR-----PKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDK 243
Query: 785 TKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPD 844
+ P K + ++ A V S +S ++ + Q+ + + K R+F + +
Sbjct: 244 PRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDD--QEGEKKRKGGRNFQTAHRRN 301
Query: 845 LLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKE------ 898
+LK Q K+AA Q Q KD+G K P + K +E
Sbjct: 302 MLKGQHEKEAAD----RKRKQEEQMETEQQNKDEG------KKPEVKKVEKKRETSMDSR 351
Query: 899 -----------LNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTE-EVRNL 946
L +D+++C AL E ++L ++ + T K+ +V +
Sbjct: 352 LQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQV 411
Query: 947 LLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLS-SECHSKQELEADVSHKETKR---KLVE 1002
++E+ +F K F + + QVL+ S +Q EA+ + + K+ K +E
Sbjct: 412 IMEKSTMLYNKF--KNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLE 469
Query: 1003 AENSKSKRKKPNEYSK--NLEKTNRKSEELSKRNN-SSGIKLDSSKDSGTE 1050
E + SK ++ N + N +S E SK N+ +S K SS++ TE
Sbjct: 470 KEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 50.8 bits (120), Expect = 1e-05
Identities = 117/585 (20%), Positives = 240/585 (41%), Gaps = 97/585 (16%)
Query: 580 ESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSL 639
E+E SLL + RRS R+ +TP R +++ V NS + + + EK L
Sbjct: 603 ENEVSLLLEES--DLRRSPRVKTTPLR---RPTETNPVTSNSDEECNE----TVKEKQKL 653
Query: 640 YTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGG-----FTSQIRKAS 694
+VP + + I PK +K +K+SE + ++ + S
Sbjct: 654 ------SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMS 707
Query: 695 NTSKNISKAKQLIEKAKALHISRSKV-TEEIAIPLRRSSRHQTLPERKKLSETEDSVIII 753
++S + + ++ K L+ +++ ++ R+SS + + KK + S+I
Sbjct: 708 HSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISK 767
Query: 754 DSSPT---ALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADP- 809
T + + + +K+++ ++ + + T+ K +P + ++K D
Sbjct: 768 KKRQTQSESSNYDSELEKEIKSMSKIGAAR--TTKKRIPNTKDFDSSEDEKHSKKGMDNQ 825
Query: 810 ----VPSFDESSQDTSEKSQDCDVQCKAK----RDFLMSGLPDLL--KRQIAKKAAALDV 859
+ + E S D +E+ Q+ + A+ +D + L D L K+Q + +D
Sbjct: 826 GHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDK 885
Query: 860 YNAVSTSF-----QRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALG 914
+ SF ++V ++K HLK +C K++ + D+++ +
Sbjct: 886 LSGKEQSFTSLEVRKVAETKEKSK-----HLKTKTC------KKVQDGLSDIAEKFL--- 931
Query: 915 EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEH 974
K +S ++ + K+ TEE + P KK + +++Q E
Sbjct: 932 ------KKDQSDETSEDDKKQSKKGTEEKKK----------PSDFKKKV--IKMEQQYES 973
Query: 975 QVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELS--- 1031
SS+ K ++ H K ++ + ++K K +KT++K +ELS
Sbjct: 974 ---SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKS----KKIRDKTSKKKDELSDYA 1026
Query: 1032 KRNNSSGIKLDSSKDSGTED-----------MLWTEKYQPQTASELIGNELAIKKLHSWL 1080
+++ G DSS+D +++ +L + Q S + ++K+
Sbjct: 1027 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS 1086
Query: 1081 KDWK-RRAELEERQNLKGKRDEKH-EDFSGGIDFKGSSDDEEESR 1123
D + +R EL ER+NL KR+ K + S D + SS+D ++ +
Sbjct: 1087 SDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK 1131
Score = 50.4 bits (119), Expect = 2e-05
Identities = 147/759 (19%), Positives = 291/759 (38%), Gaps = 108/759 (14%)
Query: 68 KTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRV-NLSHQLNNI 126
++ +N ++L KE K S + K + S+ + K +K + N H+ N+
Sbjct: 773 QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHK--NL 830
Query: 127 KTENEAPIEISSDDS-----KEDYSLNNDFVESSTSVLRY------KKQVEVLAENIQDT 175
KT E SSDD+ +E +S V+ T+++ K+Q + +
Sbjct: 831 KTSQEG----SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKL 886
Query: 176 KSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVD-LSESLPLAEELNLLKKDGK 234
+ + TSL+ K TK K L+ + C+ V D LS+ +AE+ LKKD
Sbjct: 887 SGKEQSFTSLEVRKVAE-----TKEKSKHLKTKTCKKVQDGLSD---IAEKF--LKKDQS 936
Query: 235 DTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSE 294
D ++ + + + +I + + S K+ E + IC +
Sbjct: 937 DETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREE----ICHFPK 992
Query: 295 TVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIP-------------- 340
+ +I K+G ++ + S+++R KT ++ K TGK
Sbjct: 993 GIKQI-KNG---TTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGA 1048
Query: 341 --------RIFLKQKQFEMENSLSDPENEQTVQ-------KRKSNVVIQEE-----ELEL 380
++ K + + S SD E + KR + ++E +
Sbjct: 1049 YGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNT 1108
Query: 381 AVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALK----NGVKKSSD-KQKDLNEKCLY 435
+++GSS + + + + +++ + + + +K N ++ S+ KQ D+
Sbjct: 1109 KEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1168
Query: 436 EVGRDDNSKKIMENSGIQMVSK--NGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPG 493
++ DD+ I E S + K NL L + G ++ L K T+D
Sbjct: 1169 DI-EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD-DD 1226
Query: 494 KNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVS 553
+ E KK +K + + E K T NE ++ A + + S
Sbjct: 1227 NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1286
Query: 554 SLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRR-SGRISSTPTTETIRGI 612
++++ S+K + ++ + ++ E+ + PK + GR ++E
Sbjct: 1287 D--SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1344
Query: 613 D------SDDV---QDNSQLKASTQKAANLSEKHSLYTAEL----ITVPFDSESPIRMKF 659
D S++V +D + + + K A L E Y + I V DS S +
Sbjct: 1345 DFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1404
Query: 660 TRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSK 719
K+ +++ + E+ E + + + K K +++++ K +++
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDEND------DSKSPGKGRKKIRKILKDDKLRTETQNA 1458
Query: 720 VTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPT 758
+ EE R + R + ER+KL E + I D+SPT
Sbjct: 1459 LKEEEERRKRIAERER---EREKLREV---IEIEDASPT 1491
Score = 45.1 bits (105), Expect = 7e-04
Identities = 209/1112 (18%), Positives = 403/1112 (36%), Gaps = 151/1112 (13%)
Query: 82 CKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNI--KTENEAPIEISSD 139
C I PE + +D C + E + + K+K S + N + T +P + SS+
Sbjct: 227 CYICHPEPL-LDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSN 285
Query: 140 DSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTK 199
+ E+ L++ S SV + V E I+ K T ++ +S KQ T
Sbjct: 286 CNGEEKKLDDS---CSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDN 342
Query: 200 NDFK---KLRKRKCRDVV--DLSES-LPLAEELNLLKKDGKDTKQMENTTSHANSRDNVT 253
++ KLR+ K V D+ ++ L L E+LN + + +NT H
Sbjct: 343 SEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFE 402
Query: 254 EAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEI 313
A+ + + ++ KS + +++ M VP+E +G E + S+
Sbjct: 403 TKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTG--GEHKKSDR 460
Query: 314 SQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMEN-------------------- 353
++ +++ + +P + + ME
Sbjct: 461 KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVES 520
Query: 354 -----SLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKC--TLEERQQFMKA 406
++S +N ++ + + V +E ++L + +S C +++ +
Sbjct: 521 SSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSC 580
Query: 407 FRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTD 466
P + G + S ++ NE L D ++ + ++ ++ + ++D
Sbjct: 581 GLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSD 640
Query: 467 K--GSFLKEKNK---KLKKKNKKTLDTGAI--PGKNR----------EGNTQKKETTFFL 509
+ +KEK K ++KK+K+ AI P N+ + N+ E L
Sbjct: 641 EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAIL 700
Query: 510 KEKQYQNRMSLRQRKTEFFKSS--TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSI 567
KE + S ++ TL++ ++ +D K S+ ++ + S
Sbjct: 701 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA 760
Query: 568 PVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTE----TIRGIDSDDVQDNSQL 623
I + + +SE+S + K + +I + TT+ + DS + + +S+
Sbjct: 761 KSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKK 820
Query: 624 KASTQKAANL--SEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEA 681
Q NL S++ S AE ++ S + +T + + + K+ + S +
Sbjct: 821 GMDNQGHKNLKTSQEGSSDDAER-KQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS 879
Query: 682 TDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERK 741
TDG ++ S TS + K + EK+K L K ++
Sbjct: 880 TDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD------------------ 921
Query: 742 KLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVR 801
LS+ + + D S + +K KK T K P K +
Sbjct: 922 GLSDIAEKFLKKDQSDETSEDDKKQSKK------------GTEEKKKPSDFK-------K 962
Query: 802 KAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYN 861
K K S + ++ E+ + C K+ + +G D K+ +KK + +
Sbjct: 963 KVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQ--IKNGTTDGEKK--SKK-----IRD 1013
Query: 862 AVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNS 921
S + +K G K SC K N K LG+ S
Sbjct: 1014 KTSKKKDELSDYAEKSTG------KGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ 1067
Query: 922 KLKSGNSAAVFMRTR--KEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSS 979
S ++ M+ + ++ + L E R S K+ K+I+ SS
Sbjct: 1068 DCSSSDTEKYSMKEDGCNSSDKRLKRIELRERR----NLSSKRN-----TKEIQSGSSSS 1118
Query: 980 ECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGI 1039
+A+ S ++ K+K + +SK K E +N +T+ K ++ ++SS
Sbjct: 1119 --------DAEESSEDNKKK-KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1169
Query: 1040 KLDSSKDSGTEDMLWTEKYQPQTASELI----------GNELAIKKLHSWLKDWKRRAEL 1089
D ++S E +K +P T + ++ G+E K + + D +
Sbjct: 1170 IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP 1229
Query: 1090 EERQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
E R K +E + S D GSSDDE E
Sbjct: 1230 ENRIAKKMLLEEIKANLSS--DEDGSSDDEPE 1259
Score = 40.4 bits (93), Expect = 0.016
Identities = 230/1238 (18%), Positives = 449/1238 (36%), Gaps = 239/1238 (19%)
Query: 24 CKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPK--------PSNILDYFRKTSPTNEK 75
C +K D S ++T S L ++ + K S+ + + ++ + +E
Sbjct: 286 CNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEI 345
Query: 76 TQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKK----KRKRVNLSHQLNNIKTENE 131
+ K ++K+ +SV D K LE N EF+ +++ H++ + K E +
Sbjct: 346 SSATKLRQLKAFKSVLADIKK-AHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETK 404
Query: 132 APIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKV 191
A K D +S + R + E + +N+ + + N T ++ K
Sbjct: 405 A-----RKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSD 459
Query: 192 NPKQ-----GTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHA 246
++ T D D+V + S+P NL + +++++ H
Sbjct: 460 RKEEPQYEPANTSEDLDM-------DIVSVPSSVPEDIFENL-----ETAMEVQSSVDHQ 507
Query: 247 NSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYIS 306
+ TE +E+ S++ + + S+ G I
Sbjct: 508 GDGSSGTE-------------------------QEVESSSVKLNISSKD-----NRGGIK 537
Query: 307 ESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQK 366
+++++++ K V PI ++P+ K + L E Q+
Sbjct: 538 SKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKL---EKCGLGQE 594
Query: 367 RKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQ 426
N + E E+ L + E+ + + K T R + + VK+
Sbjct: 595 NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 654
Query: 427 KDLNEKCLYEVGRD--DNSK--KIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKK- 481
+ +K DN K K+ ++ + V +N + + + LKE ++
Sbjct: 655 VPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSD---EMLAILKEVSRMSHSSS 711
Query: 482 ----------NKKTL-DTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKS 530
N KTL D GK+ +G ++K +T + + + + K
Sbjct: 712 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST---SGSDFDTKKGKSAKSSIISKK 768
Query: 531 STLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASL----- 585
+ES Y+ ++ +S + + ++K KD ++ + S+ +
Sbjct: 769 KRQTQSESSNYDSELEKEIKSMSKI-GAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGH 827
Query: 586 --LNVSTPKSTRRSGRISSTPTTETIRG-IDSD----DVQDN----SQLKASTQKAANLS 634
L S S+ + R T + G +D D +++D Q AST LS
Sbjct: 828 KNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLS 887
Query: 635 EKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEK------SEATDGGFTS 688
K +T+ + V +E+ + K + T KK + + +EK S+ T
Sbjct: 888 GKEQSFTS--LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK 945
Query: 689 QIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETED 748
Q +K + K S K+ + K + + S S TE+ LPER+++
Sbjct: 946 QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK-------------LPEREEICHFPK 992
Query: 749 SVIIIDSSPT-----ALKHPEKNQKKLQCLNDVLGKKLNT-----------STKNVPGKM 792
+ I + T + K +K KK L+D K S G+
Sbjct: 993 GIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGRE 1052
Query: 793 KVAPLFLVRKAQKAADPVPSFDESSQDT---SEKSQDCDVQCKAKRDFLMSGLPDLLKRQ 849
K L + ++K D SS DT S K C+ K + + +L ++
Sbjct: 1053 KKRCKLLGKSSRKRQDC------SSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1106
Query: 850 IAKK----AAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVID 905
K+ +++ D + + ++ K + K S TK K+ + +
Sbjct: 1107 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD--ITS 1164
Query: 906 LSKCGI------ALGEFSTLNSKLK-----------------SGNSA---AVFMRTRKEF 939
S I ++GE S+ K+K SG+ A +V + +
Sbjct: 1165 SSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD 1224
Query: 940 TEE------VRNLLLEEIRWS-----------NPEFSLKKYFPLLLKKQIEHQVLSSECH 982
+ + +LLEEI+ + PE K+ KQ E E
Sbjct: 1225 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR-----TGKQNEENPGDEEAK 1279
Query: 983 SKQELEADVSHKETKR------------KLVEAENSKSKRKKPNEYSKNLEKTNRK-SEE 1029
++ E+D +E+K+ + + E+ + K+ KP E+ + + RK S E
Sbjct: 1280 NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSE 1339
Query: 1030 LSKRNN--SSGIKLDSSKDSGTEDMLWTEKYQPQTAS----ELIGNELAIKKLHSWLKDW 1083
S+ ++ SG+ S + S +ED + +P+T S EL N+ + K+ K
Sbjct: 1340 DSEDSDFQESGV---SEEVSESED-----EQRPRTRSAKKAELEENQRSYKQ-----KKK 1386
Query: 1084 KRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
+RR +++E + + K + + E+ + + ++EEE
Sbjct: 1387 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1424
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 50.8 bits (120), Expect = 1e-05
Identities = 117/585 (20%), Positives = 240/585 (41%), Gaps = 97/585 (16%)
Query: 580 ESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSL 639
E+E SLL + RRS R+ +TP R +++ V NS + + + EK L
Sbjct: 641 ENEVSLLLEES--DLRRSPRVKTTPLR---RPTETNPVTSNSDEECNE----TVKEKQKL 691
Query: 640 YTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGG-----FTSQIRKAS 694
+VP + + I PK +K +K+SE + ++ + S
Sbjct: 692 ------SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMS 745
Query: 695 NTSKNISKAKQLIEKAKALHISRSKV-TEEIAIPLRRSSRHQTLPERKKLSETEDSVIII 753
++S + + ++ K L+ +++ ++ R+SS + + KK + S+I
Sbjct: 746 HSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISK 805
Query: 754 DSSPT---ALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADP- 809
T + + + +K+++ ++ + + T+ K +P + ++K D
Sbjct: 806 KKRQTQSESSNYDSELEKEIKSMSKIGAAR--TTKKRIPNTKDFDSSEDEKHSKKGMDNQ 863
Query: 810 ----VPSFDESSQDTSEKSQDCDVQCKAK----RDFLMSGLPDLL--KRQIAKKAAALDV 859
+ + E S D +E+ Q+ + A+ +D + L D L K+Q + +D
Sbjct: 864 GHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDK 923
Query: 860 YNAVSTSF-----QRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALG 914
+ SF ++V ++K HLK +C K++ + D+++ +
Sbjct: 924 LSGKEQSFTSLEVRKVAETKEKSK-----HLKTKTC------KKVQDGLSDIAEKFL--- 969
Query: 915 EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEH 974
K +S ++ + K+ TEE + P KK + +++Q E
Sbjct: 970 ------KKDQSDETSEDDKKQSKKGTEEKKK----------PSDFKKKV--IKMEQQYES 1011
Query: 975 QVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELS--- 1031
SS+ K ++ H K ++ + ++K K +KT++K +ELS
Sbjct: 1012 ---SSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKS----KKIRDKTSKKKDELSDYA 1064
Query: 1032 KRNNSSGIKLDSSKDSGTED-----------MLWTEKYQPQTASELIGNELAIKKLHSWL 1080
+++ G DSS+D +++ +L + Q S + ++K+
Sbjct: 1065 EKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS 1124
Query: 1081 KDWK-RRAELEERQNLKGKRDEKH-EDFSGGIDFKGSSDDEEESR 1123
D + +R EL ER+NL KR+ K + S D + SS+D ++ +
Sbjct: 1125 SDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKK 1169
Score = 50.4 bits (119), Expect = 2e-05
Identities = 147/759 (19%), Positives = 291/759 (38%), Gaps = 108/759 (14%)
Query: 68 KTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRV-NLSHQLNNI 126
++ +N ++L KE K S + K + S+ + K +K + N H+ N+
Sbjct: 811 QSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHK--NL 868
Query: 127 KTENEAPIEISSDDS-----KEDYSLNNDFVESSTSVLRY------KKQVEVLAENIQDT 175
KT E SSDD+ +E +S V+ T+++ K+Q + +
Sbjct: 869 KTSQEG----SSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKL 924
Query: 176 KSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVD-LSESLPLAEELNLLKKDGK 234
+ + TSL+ K TK K L+ + C+ V D LS+ +AE+ LKKD
Sbjct: 925 SGKEQSFTSLEVRKVAE-----TKEKSKHLKTKTCKKVQDGLSD---IAEKF--LKKDQS 974
Query: 235 DTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSE 294
D ++ + + + +I + + S K+ E + IC +
Sbjct: 975 DETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREE----ICHFPK 1030
Query: 295 TVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIP-------------- 340
+ +I K+G ++ + S+++R KT ++ K TGK
Sbjct: 1031 GIKQI-KNG---TTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGA 1086
Query: 341 --------RIFLKQKQFEMENSLSDPENEQTVQ-------KRKSNVVIQEE-----ELEL 380
++ K + + S SD E + KR + ++E +
Sbjct: 1087 YGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNT 1146
Query: 381 AVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALK----NGVKKSSD-KQKDLNEKCLY 435
+++GSS + + + + +++ + + + +K N ++ S+ KQ D+
Sbjct: 1147 KEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1206
Query: 436 EVGRDDNSKKIMENSGIQMVSK--NGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPG 493
++ DD+ I E S + K NL L + G ++ L K T+D
Sbjct: 1207 DI-EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD-DD 1264
Query: 494 KNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVS 553
+ E KK +K + + E K T NE ++ A + + S
Sbjct: 1265 NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSES 1324
Query: 554 SLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRR-SGRISSTPTTETIRGI 612
++++ S+K + ++ + ++ E+ + PK + GR ++E
Sbjct: 1325 D--SDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDS 1382
Query: 613 D------SDDV---QDNSQLKASTQKAANLSEKHSLYTAEL----ITVPFDSESPIRMKF 659
D S++V +D + + + K A L E Y + I V DS S +
Sbjct: 1383 DFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNS 1442
Query: 660 TRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSK 719
K+ +++ + E+ E + + + K K +++++ K +++
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDEND------DSKSPGKGRKKIRKILKDDKLRTETQNA 1496
Query: 720 VTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPT 758
+ EE R + R + ER+KL E + I D+SPT
Sbjct: 1497 LKEEEERRKRIAERER---EREKLREV---IEIEDASPT 1529
Score = 45.1 bits (105), Expect = 7e-04
Identities = 209/1112 (18%), Positives = 403/1112 (36%), Gaps = 151/1112 (13%)
Query: 82 CKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNI--KTENEAPIEISSD 139
C I PE + +D C + E + + K+K S + N + T +P + SS+
Sbjct: 265 CYICHPEPL-LDLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPKKTSSN 323
Query: 140 DSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTK 199
+ E+ L++ S SV + V E I+ K T ++ +S KQ T
Sbjct: 324 CNGEEKKLDDS---CSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDN 380
Query: 200 NDFK---KLRKRKCRDVV--DLSES-LPLAEELNLLKKDGKDTKQMENTTSHANSRDNVT 253
++ KLR+ K V D+ ++ L L E+LN + + +NT H
Sbjct: 381 SEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFE 440
Query: 254 EAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEI 313
A+ + + ++ KS + +++ M VP+E +G E + S+
Sbjct: 441 TKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTG--GEHKKSDR 498
Query: 314 SQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMEN-------------------- 353
++ +++ + +P + + ME
Sbjct: 499 KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVES 558
Query: 354 -----SLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKC--TLEERQQFMKA 406
++S +N ++ + + V +E ++L + +S C +++ +
Sbjct: 559 SSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSC 618
Query: 407 FRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTD 466
P + G + S ++ NE L D ++ + ++ ++ + ++D
Sbjct: 619 GLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSD 678
Query: 467 K--GSFLKEKNK---KLKKKNKKTLDTGAI--PGKNR----------EGNTQKKETTFFL 509
+ +KEK K ++KK+K+ AI P N+ + N+ E L
Sbjct: 679 EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAIL 738
Query: 510 KEKQYQNRMSLRQRKTEFFKSS--TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSI 567
KE + S ++ TL++ ++ +D K S+ ++ + S
Sbjct: 739 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA 798
Query: 568 PVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTE----TIRGIDSDDVQDNSQL 623
I + + +SE+S + K + +I + TT+ + DS + + +S+
Sbjct: 799 KSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKK 858
Query: 624 KASTQKAANL--SEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEA 681
Q NL S++ S AE ++ S + +T + + + K+ + S +
Sbjct: 859 GMDNQGHKNLKTSQEGSSDDAER-KQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS 917
Query: 682 TDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERK 741
TDG ++ S TS + K + EK+K L K ++
Sbjct: 918 TDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQD------------------ 959
Query: 742 KLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVR 801
LS+ + + D S + +K KK T K P K +
Sbjct: 960 GLSDIAEKFLKKDQSDETSEDDKKQSKK------------GTEEKKKPSDFK-------K 1000
Query: 802 KAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYN 861
K K S + ++ E+ + C K+ + +G D K+ +KK + +
Sbjct: 1001 KVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQ--IKNGTTDGEKK--SKK-----IRD 1051
Query: 862 AVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNS 921
S + +K G K SC K N K LG+ S
Sbjct: 1052 KTSKKKDELSDYAEKSTG------KGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ 1105
Query: 922 KLKSGNSAAVFMRTR--KEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSS 979
S ++ M+ + ++ + L E R S K+ K+I+ SS
Sbjct: 1106 DCSSSDTEKYSMKEDGCNSSDKRLKRIELRERR----NLSSKRN-----TKEIQSGSSSS 1156
Query: 980 ECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGI 1039
+A+ S ++ K+K + +SK K E +N +T+ K ++ ++SS
Sbjct: 1157 --------DAEESSEDNKKK-KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSD 1207
Query: 1040 KLDSSKDSGTEDMLWTEKYQPQTASELI----------GNELAIKKLHSWLKDWKRRAEL 1089
D ++S E +K +P T + ++ G+E K + + D +
Sbjct: 1208 IEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP 1267
Query: 1090 EERQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
E R K +E + S D GSSDDE E
Sbjct: 1268 ENRIAKKMLLEEIKANLSS--DEDGSSDDEPE 1297
Score = 40.4 bits (93), Expect = 0.016
Identities = 230/1238 (18%), Positives = 449/1238 (36%), Gaps = 239/1238 (19%)
Query: 24 CKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPK--------PSNILDYFRKTSPTNEK 75
C +K D S ++T S L ++ + K S+ + + ++ + +E
Sbjct: 324 CNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEI 383
Query: 76 TQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKK----KRKRVNLSHQLNNIKTENE 131
+ K ++K+ +SV D K LE N EF+ +++ H++ + K E +
Sbjct: 384 SSATKLRQLKAFKSVLADIKK-AHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETK 442
Query: 132 APIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKV 191
A K D +S + R + E + +N+ + + N T ++ K
Sbjct: 443 A-----RKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSD 497
Query: 192 NPKQ-----GTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHA 246
++ T D D+V + S+P NL + +++++ H
Sbjct: 498 RKEEPQYEPANTSEDLDM-------DIVSVPSSVPEDIFENL-----ETAMEVQSSVDHQ 545
Query: 247 NSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYIS 306
+ TE +E+ S++ + + S+ G I
Sbjct: 546 GDGSSGTE-------------------------QEVESSSVKLNISSKD-----NRGGIK 575
Query: 307 ESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQK 366
+++++++ K V PI ++P+ K + L E Q+
Sbjct: 576 SKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKL---EKCGLGQE 632
Query: 367 RKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQ 426
N + E E+ L + E+ + + K T R + + VK+
Sbjct: 633 NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 692
Query: 427 KDLNEKCLYEVGRD--DNSK--KIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKK- 481
+ +K DN K K+ ++ + V +N + + + LKE ++
Sbjct: 693 VPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSD---EMLAILKEVSRMSHSSS 749
Query: 482 ----------NKKTL-DTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKS 530
N KTL D GK+ +G ++K +T + + + + K
Sbjct: 750 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST---SGSDFDTKKGKSAKSSIISKK 806
Query: 531 STLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASL----- 585
+ES Y+ ++ +S + + ++K KD ++ + S+ +
Sbjct: 807 KRQTQSESSNYDSELEKEIKSMSKI-GAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGH 865
Query: 586 --LNVSTPKSTRRSGRISSTPTTETIRG-IDSD----DVQDN----SQLKASTQKAANLS 634
L S S+ + R T + G +D D +++D Q AST LS
Sbjct: 866 KNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLS 925
Query: 635 EKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEK------SEATDGGFTS 688
K +T+ + V +E+ + K + T KK + + +EK S+ T
Sbjct: 926 GKEQSFTS--LEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK 983
Query: 689 QIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETED 748
Q +K + K S K+ + K + + S S TE+ LPER+++
Sbjct: 984 QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK-------------LPEREEICHFPK 1030
Query: 749 SVIIIDSSPT-----ALKHPEKNQKKLQCLNDVLGKKLNT-----------STKNVPGKM 792
+ I + T + K +K KK L+D K S G+
Sbjct: 1031 GIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGRE 1090
Query: 793 KVAPLFLVRKAQKAADPVPSFDESSQDT---SEKSQDCDVQCKAKRDFLMSGLPDLLKRQ 849
K L + ++K D SS DT S K C+ K + + +L ++
Sbjct: 1091 KKRCKLLGKSSRKRQDC------SSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1144
Query: 850 IAKK----AAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVID 905
K+ +++ D + + ++ K + K S TK K+ + +
Sbjct: 1145 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD--ITS 1202
Query: 906 LSKCGI------ALGEFSTLNSKLK-----------------SGNSA---AVFMRTRKEF 939
S I ++GE S+ K+K SG+ A +V + +
Sbjct: 1203 SSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDD 1262
Query: 940 TEE------VRNLLLEEIRWS-----------NPEFSLKKYFPLLLKKQIEHQVLSSECH 982
+ + +LLEEI+ + PE K+ KQ E E
Sbjct: 1263 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKR-----TGKQNEENPGDEEAK 1317
Query: 983 SKQELEADVSHKETKR------------KLVEAENSKSKRKKPNEYSKNLEKTNRK-SEE 1029
++ E+D +E+K+ + + E+ + K+ KP E+ + + RK S E
Sbjct: 1318 NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSE 1377
Query: 1030 LSKRNN--SSGIKLDSSKDSGTEDMLWTEKYQPQTAS----ELIGNELAIKKLHSWLKDW 1083
S+ ++ SG+ S + S +ED + +P+T S EL N+ + K+ K
Sbjct: 1378 DSEDSDFQESGV---SEEVSESED-----EQRPRTRSAKKAELEENQRSYKQ-----KKK 1424
Query: 1084 KRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEE 1121
+RR +++E + + K + + E+ + + ++EEE
Sbjct: 1425 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEE 1462
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 50.8 bits (120), Expect = 1e-05
Identities = 107/471 (22%), Positives = 182/471 (38%), Gaps = 72/471 (15%)
Query: 900 NTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFS 959
+ KV DL++ E L +++K S ++ K ++++ L E + S
Sbjct: 285 DNKVKDLNQ------EIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Query: 960 LKKYFPLLLKKQIEHQ----------VLSSECHSKQEL-----EADVSHKETKRKLVEAE 1004
+ L +KKQ E + + S H + + EA VS K T R+L +
Sbjct: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVS-KHTAREL--SP 395
Query: 1005 NSKSKRKKPNEYSKNLEK---TNRK--SEELSKRNNSSGIKLDSSKDSGTEDMLWTE-KY 1058
K +R + E++ N E +NR+ S + R + + S DSGT++ TE ++
Sbjct: 396 QHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRF 455
Query: 1059 QPQTASE----------LIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSG 1108
P ++ ++ + HS K WK ++ LKGK ++ FS
Sbjct: 456 VPGSSQSEGKKSREQPSVLSRYPPAAQEHS--KAWKGTSKPGTESGLKGKVEKTTRTFSD 513
Query: 1109 GIDFKGSSD-----DEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRS 1163
SD D+ TV +G + V A K ASS+RS
Sbjct: 514 TTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRS 573
Query: 1164 GRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKI-----SSPKKVVTSPRKV 1218
+ LS+ K+A + D NS+ P Y +S + I +S K+ V P V
Sbjct: 574 SSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAV 633
Query: 1219 PPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKST 1278
+ S P AL + + + + P ++ +I L+ ++ T T
Sbjct: 634 ---VMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLV-----------TAKLVNTTIT 679
Query: 1279 NATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLN-AIKTFMATT 1328
+ E+ + A LFE D+DAG N ++K+ A+T
Sbjct: 680 PEPEPKPQPNSREKAKTRGAPRTSLFEN-----DKDAGMENESVKSVRAST 725
Score = 33.9 bits (76), Expect = 1.5
Identities = 87/446 (19%), Positives = 172/446 (38%), Gaps = 56/446 (12%)
Query: 413 DALKNGVKKSSDKQKDLNEKCLYEVGRDDNSK---KIMENSGIQMVSKNGNLQLHTDKGS 469
+A KN ++K+ D+ DL +K + G + + +++ +++ K+ ++ D
Sbjct: 32 EATKN-LQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR 90
Query: 470 FLKEK-------NKKLKKKNKKTLDTGAIPGKNREGNTQKK----ETTFFLKE-----KQ 513
+KEK ++LK + ++ A K E ++ K + L E K+
Sbjct: 91 LMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
Query: 514 YQNRMSLRQRKTEFFKSST--LFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKD 571
+ + + + K + +SS L E + ++ L +S + L+ K K
Sbjct: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
Query: 572 IKLTQSKAESEASLLNVSTPKSTR--------RSGRISSTPTTETIR--GIDS-DDVQDN 620
IK K E + T ++ G S+ P+ E+ R G+D V++
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 621 SQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSE 680
++ K+ +K N + D I T+I + +++ K K+
Sbjct: 271 TRNKSENEKNRNQEDNKVK----------DLNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
Query: 681 ATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPER 740
+ S+ K + + + K I+K K L +V E A L RH+ R
Sbjct: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE--NGEVEGEDAF-LSSKGRHERTKFR 377
Query: 741 KKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLV 800
SE + P+ +++L+ L N ++ + +P F
Sbjct: 378 GHGSEAS-----VSKHTARELSPQHKRERLRNREFAL----NNENYSLSNRQVSSPSFTN 428
Query: 801 RKAQKAADPVPSFDESSQDTSEKSQD 826
R+A KA+ S D +Q+T +K++D
Sbjct: 429 RRAAKASHMGVSTDSGTQET-KKTED 453
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 50.8 bits (120), Expect = 1e-05
Identities = 107/471 (22%), Positives = 182/471 (38%), Gaps = 72/471 (15%)
Query: 900 NTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFS 959
+ KV DL++ E L +++K S ++ K ++++ L E + S
Sbjct: 285 DNKVKDLNQ------EIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Query: 960 LKKYFPLLLKKQIEHQ----------VLSSECHSKQEL-----EADVSHKETKRKLVEAE 1004
+ L +KKQ E + + S H + + EA VS K T R+L +
Sbjct: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVS-KHTAREL--SP 395
Query: 1005 NSKSKRKKPNEYSKNLEK---TNRK--SEELSKRNNSSGIKLDSSKDSGTEDMLWTE-KY 1058
K +R + E++ N E +NR+ S + R + + S DSGT++ TE ++
Sbjct: 396 QHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRF 455
Query: 1059 QPQTASE----------LIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSG 1108
P ++ ++ + HS K WK ++ LKGK ++ FS
Sbjct: 456 VPGSSQSEGKKSREQPSVLSRYPPAAQEHS--KAWKGTSKPGTESGLKGKVEKTTRTFSD 513
Query: 1109 GIDFKGSSD-----DEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRS 1163
SD D+ TV +G + V A K ASS+RS
Sbjct: 514 TTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRS 573
Query: 1164 GRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKI-----SSPKKVVTSPRKV 1218
+ LS+ K+A + D NS+ P Y +S + I +S K+ V P V
Sbjct: 574 SSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAV 633
Query: 1219 PPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKST 1278
+ S P AL + + + + P ++ +I L+ ++ T T
Sbjct: 634 ---VMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLV-----------TAKLVNTTIT 679
Query: 1279 NATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLN-AIKTFMATT 1328
+ E+ + A LFE D+DAG N ++K+ A+T
Sbjct: 680 PEPEPKPQPNSREKAKTRGAPRTSLFEN-----DKDAGMENESVKSVRAST 725
Score = 33.9 bits (76), Expect = 1.5
Identities = 87/446 (19%), Positives = 172/446 (38%), Gaps = 56/446 (12%)
Query: 413 DALKNGVKKSSDKQKDLNEKCLYEVGRDDNSK---KIMENSGIQMVSKNGNLQLHTDKGS 469
+A KN ++K+ D+ DL +K + G + + +++ +++ K+ ++ D
Sbjct: 32 EATKN-LQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR 90
Query: 470 FLKEK-------NKKLKKKNKKTLDTGAIPGKNREGNTQKK----ETTFFLKE-----KQ 513
+KEK ++LK + ++ A K E ++ K + L E K+
Sbjct: 91 LMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
Query: 514 YQNRMSLRQRKTEFFKSST--LFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKD 571
+ + + + K + +SS L E + ++ L +S + L+ K K
Sbjct: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
Query: 572 IKLTQSKAESEASLLNVSTPKSTR--------RSGRISSTPTTETIR--GIDS-DDVQDN 620
IK K E + T ++ G S+ P+ E+ R G+D V++
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 621 SQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSE 680
++ K+ +K N + D I T+I + +++ K K+
Sbjct: 271 TRNKSENEKNRNQEDNKVK----------DLNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
Query: 681 ATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPER 740
+ S+ K + + + K I+K K L +V E A L RH+ R
Sbjct: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE--NGEVEGEDAF-LSSKGRHERTKFR 377
Query: 741 KKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLV 800
SE + P+ +++L+ L N ++ + +P F
Sbjct: 378 GHGSEAS-----VSKHTARELSPQHKRERLRNREFAL----NNENYSLSNRQVSSPSFTN 428
Query: 801 RKAQKAADPVPSFDESSQDTSEKSQD 826
R+A KA+ S D +Q+T +K++D
Sbjct: 429 RRAAKASHMGVSTDSGTQET-KKTED 453
>gi|19718796 RAD17 homolog isoform 1 [Homo sapiens]
Length = 670
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 33 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 90
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 91 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 121
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 122 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 149
>gi|19718794 RAD17 homolog isoform 1 [Homo sapiens]
Length = 670
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 33 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 90
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 91 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 121
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 122 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 149
>gi|19718792 RAD17 homolog isoform 1 [Homo sapiens]
Length = 670
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 33 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 90
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 91 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 121
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 122 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 149
>gi|19718784 RAD17 homolog isoform 1 [Homo sapiens]
Length = 670
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 33 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 90
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 91 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 121
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 122 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 149
>gi|4506383 RAD17 homolog isoform 1 [Homo sapiens]
Length = 670
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 33 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 90
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 91 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 121
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 122 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 149
>gi|19718786 RAD17 homolog isoform 2 [Homo sapiens]
Length = 681
Score = 50.8 bits (120), Expect = 1e-05
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 34/151 (22%)
Query: 1005 NSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTAS 1064
NS +RK ++ RK LS G L++SK+ +E+ W +KY+P+T
Sbjct: 44 NSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYG--LENSKEYLSENEPWVDKYKPETQH 101
Query: 1065 ELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
EL ++ I+++ +WLK A++ ERQ +G G I
Sbjct: 102 ELAVHKKKIEEVETWLK-----AQVLERQPKQG----------GSI-------------- 132
Query: 1125 CNTVLITGPTGVGKTAAVYACAQELGFKIFE 1155
+LITGP G GKT + ++E G ++ E
Sbjct: 133 ---LLITGPPGCGKTTTLKILSKEHGIQVQE 160
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 49.7 bits (117), Expect = 3e-05
Identities = 132/702 (18%), Positives = 287/702 (40%), Gaps = 72/702 (10%)
Query: 83 KIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSK 142
+ K E ++ NK L M KK RK + Q + + I ++
Sbjct: 563 EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 622
Query: 143 EDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGT-TKND 201
+ SL+N+ E + ++ +++ E I+ K + + + + ++ V P++ K+
Sbjct: 623 KS-SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-KLAQHVKPEEHEQVKSR 680
Query: 202 FKKLRKRKCRDVVDLS-ESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLND 260
++ + + +L+ ++ L +E+ + D K K+ + N+T ++ +
Sbjct: 681 LEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAH---------NLT--IEMKN 729
Query: 261 SIITVSYEEFLKSHKENKVEEIPDSTMSICVP-SETVDEIVKSGYISESENSEISQQVRF 319
+ + E +K + ++++ + + +E E+ K ++S + ++S R
Sbjct: 730 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS---RL 786
Query: 320 KTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELE 379
+TV V PP+K K I LK E++ LS+ + + + K + + E
Sbjct: 787 ETVFV-------PPEKHEK-EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN--- 835
Query: 380 LAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGR 439
L+ S P T EE + + + L + VKK K +D+N++ + +
Sbjct: 836 -TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD-VKK---KFEDINQEFVKIKDK 890
Query: 440 DDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGN 499
++ K+ +EN+ Q+ ++ +L H K S L + +K++ N + L R+G
Sbjct: 891 NEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL------ANYRKG- 943
Query: 500 TQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNN 559
Q++ T + K + + Q + K + + + E + A + LK +
Sbjct: 944 -QEEIVTLHAEIKAQKKELDTIQECIK-VKYAPIVSFEECERKFKATEKELK-------D 994
Query: 560 KLSRKT-SIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQ 618
+LS +T V + ++ ++K E++ + T + R + + E R + +
Sbjct: 995 QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDE 1054
Query: 619 DNSQLKASTQK-------AANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKK 671
N QLK +QK L E+++ T+E++ V ++ ++ + + + KK
Sbjct: 1055 LNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV----QNLLQKQHVPLEQVEALKKS 1110
Query: 672 SNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAK------ALHISRSKVTEEIA 725
N E + S R + ++K QL+E K A H+ + E+
Sbjct: 1111 LNGTIENLKEE---LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEV 1167
Query: 726 IPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQ 767
++ S R + + K+ E + ++ ALK E +
Sbjct: 1168 GIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE 1209
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 49.7 bits (117), Expect = 3e-05
Identities = 132/702 (18%), Positives = 287/702 (40%), Gaps = 72/702 (10%)
Query: 83 KIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSK 142
+ K E ++ NK L M KK RK + Q + + I ++
Sbjct: 576 EFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM 635
Query: 143 EDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGT-TKND 201
+ SL+N+ E + ++ +++ E I+ K + + + + ++ V P++ K+
Sbjct: 636 KS-SLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-KLAQHVKPEEHEQVKSR 693
Query: 202 FKKLRKRKCRDVVDLS-ESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLND 260
++ + + +L+ ++ L +E+ + D K K+ + N+T ++ +
Sbjct: 694 LEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAH---------NLT--IEMKN 742
Query: 261 SIITVSYEEFLKSHKENKVEEIPDSTMSICVP-SETVDEIVKSGYISESENSEISQQVRF 319
+ + E +K + ++++ + + +E E+ K ++S + ++S R
Sbjct: 743 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS---RL 799
Query: 320 KTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELE 379
+TV V PP+K K I LK E++ LS+ + + + K + + E
Sbjct: 800 ETVFV-------PPEKHEK-EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN--- 848
Query: 380 LAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGR 439
L+ S P T EE + + + L + VKK K +D+N++ + +
Sbjct: 849 -TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD-VKK---KFEDINQEFVKIKDK 903
Query: 440 DDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGN 499
++ K+ +EN+ Q+ ++ +L H K S L + +K++ N + L R+G
Sbjct: 904 NEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL------ANYRKG- 956
Query: 500 TQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNN 559
Q++ T + K + + Q + K + + + E + A + LK +
Sbjct: 957 -QEEIVTLHAEIKAQKKELDTIQECIK-VKYAPIVSFEECERKFKATEKELK-------D 1007
Query: 560 KLSRKT-SIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQ 618
+LS +T V + ++ ++K E++ + T + R + + E R + +
Sbjct: 1008 QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDE 1067
Query: 619 DNSQLKASTQK-------AANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKK 671
N QLK +QK L E+++ T+E++ V ++ ++ + + + KK
Sbjct: 1068 LNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAV----QNLLQKQHVPLEQVEALKKS 1123
Query: 672 SNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAK------ALHISRSKVTEEIA 725
N E + S R + ++K QL+E K A H+ + E+
Sbjct: 1124 LNGTIENLKEE---LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEV 1180
Query: 726 IPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQ 767
++ S R + + K+ E + ++ ALK E +
Sbjct: 1181 GIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRE 1222
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 48.9 bits (115), Expect = 5e-05
Identities = 104/497 (20%), Positives = 179/497 (36%), Gaps = 106/497 (21%)
Query: 352 ENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPA 411
E + + ++ QK K + EL ++ S + KPK + F +
Sbjct: 88 EEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLP 147
Query: 412 SDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFL 471
A G + S+K+ D +E+ +DNSKKI E S I ++G+ + FL
Sbjct: 148 KKA--KGKAQKSNKKWDGSEE------DEDNSKKIKERSRINSSGESGD-----ESDEFL 194
Query: 472 KEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSS 531
+++K +KKN+K PG N E + + +F +K ++ Q+K E
Sbjct: 195 --QSRKGQKKNQKNK-----PGPNIESGNEDDDASFKIK--------TVAQKKAE----- 234
Query: 532 TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTP 591
+ +K ++ + K E E + S
Sbjct: 235 -------------------------KKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269
Query: 592 KSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDS 651
K ++R + + T+ D + AS +K AE T D
Sbjct: 270 KESQRKFEEETVKSKVTV---------DTGVIPASEEK------------AETPTAAEDD 308
Query: 652 ESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAK 711
+ K K KKK ++ EK + G + KA + ++K K+ E+ K
Sbjct: 309 NEGDKKK-------KDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA--LAKLKEEEERQK 359
Query: 712 ALHISRSKVTEEIAIPLRRSSR-HQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKL 770
R K EE+ + R Q ERKK E E + K K+Q++
Sbjct: 360 REEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEG----KLLTKSQREA 415
Query: 771 QCLNDVLGKKLNTSTKNVPGK---MKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDC 827
+ + K L VP K K P++ +K +K + S++ SE + C
Sbjct: 416 RARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQL-----ESKEVSESMELC 470
Query: 828 DVQCKAKRDFLMSGLPD 844
A + + G+P+
Sbjct: 471 -----AAVEVMEQGVPE 482
Score = 35.4 bits (80), Expect = 0.52
Identities = 50/226 (22%), Positives = 87/226 (38%), Gaps = 16/226 (7%)
Query: 915 EFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPE----FSLKKYFPLLL-- 968
E S +NS +SG+ + F+++RK + +N I N + F +K
Sbjct: 176 ERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEK 235
Query: 969 -----KKQIEHQVLSSECHSKQELEA---DVSHKETKRKLVEAENSKSKRKKPNEYSKNL 1020
KK+ E + + K+ELE D S ++ ++ E E KSK
Sbjct: 236 KERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPAS 295
Query: 1021 EKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWL 1080
E+ N K D K G ++ EK + + + + + A+ KL
Sbjct: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE 355
Query: 1081 KDWKRRAE--LEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRL 1124
+ KR E ++ + L+ KR E+ + K + E + RL
Sbjct: 356 ERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL 401
Score = 31.2 bits (69), Expect = 9.8
Identities = 20/83 (24%), Positives = 41/83 (49%), Gaps = 9/83 (10%)
Query: 1042 DSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDE 1101
+ ++D+G +D W + ++ GN K+H +K+ E EE + + + E
Sbjct: 496 EDTEDAGLDD--WEAMASDEETEKVEGN-----KVHIEVKENPEEEEEEEEEEEEDEESE 548
Query: 1102 KHEDFSGGIDFKGSSDDEEESRL 1124
+ E+ G + +GS DEE+ ++
Sbjct: 549 EEEEEEG--ESEGSEGDEEDEKV 569
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 48.5 bits (114), Expect = 6e-05
Identities = 163/842 (19%), Positives = 337/842 (40%), Gaps = 129/842 (15%)
Query: 346 QKQFEMENSLSDPENEQ----TVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQ 401
+ +++ E SL + ++ T + K VIQ+ + EL + G + K L + Q
Sbjct: 176 KSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL-LQRPGIEDVAVLKKELVQVQ 234
Query: 402 QFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNL 461
M D + ++ S+K KD +C + +S+ + ++ +
Sbjct: 235 TLM--------DNMTLERERESEKLKD---ECKKLQSQYASSEATISQLRSELAKGPQEV 283
Query: 462 QLHTDKGSFLKEKNKKLKKKN--------KKTLDTGAIPGKNREGNTQKKETTFFLKEK- 512
++ + LK +L +KN KK D + K+ E + KK L +K
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 513 ----QYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIP 568
Q Q+R+S + T + + + + + ++L +V + + K K
Sbjct: 344 LDCQQLQSRLSASE--TSLHRIHVELSEKGEATQKL-KEELSEVETKYQHLKAEFKQLQQ 400
Query: 569 VKDIKLTQS-KAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKAST 627
++ K + +SE + L+ ++ R+ G + R + S+ + D Q A
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ--RQLSSEKLMDKEQQVADL 458
Query: 628 Q-KAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGF 686
Q K + L E+ ++ K T + + K+ ++ ++ +A
Sbjct: 459 QLKLSRLEEQ------------------LKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 687 TSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSET 746
T+++R+A N + + +Q+ +K + + + + L++S + +L E+++ E
Sbjct: 501 TAKLREAQNDLEQV--LRQIGDKDQKI--------QNLEALLQKSKENISLLEKER--ED 548
Query: 747 EDSVIIIDSSPTALKHP--EKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKA- 803
+ I TA+ + EKN + + + K N S + + + +KA
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 804 -QKAADPVPSFDESSQD-------TSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAA 855
+ A D V S + S + + EK D+Q KAK + L+S + AK A
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA-------EAAKTAQ 661
Query: 856 ALDVYNAVSTSFQRVVHVQQK--------DDGCCLWHLKPPSCPLL-TKFKELNTKVIDL 906
D+ N + T+ + QQ+ D K C L + KE K + L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 907 SKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPL 966
+ + L ++K + ++ ++ KE + L++ R N + L+ L
Sbjct: 722 EQ------KTEELEGQIKKLEADSLEVKASKEQALQD----LQQQRQLNTDLELRA-TEL 770
Query: 967 LLKKQIEHQVLSSECHSKQELEADVSHKET-KRKLVEAENSKSKRKKPNEYSKNLEKTNR 1025
+ ++E +++SS ++ +L+ E+ K+KL + E K K+ ++ ++T
Sbjct: 771 SKQLEMEKEIVSS---TRLDLQKKSEALESIKQKLTKQEEEKQILKQ--DFETLSQETKI 825
Query: 1026 KSEELSKRNNSSGIKLDSSKDSGTEDM--LWTEKYQPQTASELIGN------------EL 1071
+ EEL+ R ++ +L K M L T K + S+ + N +
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 1072 AIKKLHSWLKDWKRRAELEERQNLKGKRD-----EKHEDFSGGIDFKGSSDDEEESRLCN 1126
AI L K+ K + +++ LK +++ EK ++ S + + +S E+ + N
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN 945
Query: 1127 TV 1128
T+
Sbjct: 946 TL 947
Score = 46.6 bits (109), Expect = 2e-04
Identities = 139/770 (18%), Positives = 283/770 (36%), Gaps = 117/770 (15%)
Query: 113 KRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYK-------KQV 165
K++ V + ++N+ E E E D+ K+ L + + S ++ + + ++V
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKK---LQSQYASSEATISQLRSELAKGPQEV 283
Query: 166 EVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEE 225
V + +Q KS N +T + L+E
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQT---------------------------LTE------- 309
Query: 226 LNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLND-------SIITVSYEEFLKSHKENK 278
NLLKK+ TK E + S+ N+ D S ++ S + H E
Sbjct: 310 -NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE-- 366
Query: 279 VEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGK 338
+ E ++T + E + E+ ++E ++ QQ K L I
Sbjct: 367 LSEKGEATQKL---KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ----- 418
Query: 339 IPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEE-------LELAVLEAGSSEAV 391
L K E E L + Q++ S+ + ++E L+L+ LE E V
Sbjct: 419 -----LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 392 KPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSG 451
L+ + K Q ++ K + Q DL E+ L ++G D +KI
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL-EQVLRQIG--DKDQKIQNLEA 530
Query: 452 IQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKE 511
+ LQ + S L+++ + L K + A+ + +E N +E L E
Sbjct: 531 L--------LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582
Query: 512 KQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCN--NNKLSR-KTSIP 568
K S +Q + E + A D +L + + N N++L+ K +
Sbjct: 583 KLKNQSESHKQAQENLHDQV----QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
Query: 569 VKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTET--------IRGIDSDDVQDN 620
DI Q KA++E LL+ K+ +R+ + T + + I + Q
Sbjct: 639 QLDI---QIKAKTEL-LLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVT 694
Query: 621 SQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSE 680
++L+ + + L Y + +++ +E + + ++ K S +++ +
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE-LEGQIKKLEADSLEVKASKEQALQDL 753
Query: 681 ATDGGFTSQIR-KASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPE 739
+ + +A+ SK + K+++ + +S+ E I L + E
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE------E 807
Query: 740 RKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFL 799
K++ + + + S T ++H E N + + ++ +K+ + + ++ L
Sbjct: 808 EKQILKQDFETL---SQETKIQHEELNNRIQTTVTEL--QKVKMEKEALMTELSTVKDKL 862
Query: 800 VRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQ 849
+ + + F++ +Q D + CK + L + + LK Q
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
Score = 46.2 bits (108), Expect = 3e-04
Identities = 133/707 (18%), Positives = 272/707 (38%), Gaps = 116/707 (16%)
Query: 168 LAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKR---KCRDVVDLSESLPLAE 224
L + TK Q +LQ S ++ +ND +++ ++ K + + +L L ++
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREA--QNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
Query: 225 E-LNLLKKDGKDT----KQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHK---E 276
E ++LL+K+ +D + E T+ N Q + +T + +SHK E
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 277 NKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKT 336
N +++ + + + V + S S+ +E ++V + + A+ + +
Sbjct: 597 NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 337 GKIP-RIFLKQKQFEMENSLSDPE---NEQTVQKRKSNVVIQEEELELAVLEAGSSEAVK 392
K R L+ +N+L D + N+ T Q + +Q+++ + LE+ E +
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 393 PKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGI 452
+LE++ ++ L+ +KK + D K + +
Sbjct: 717 KYLSLEQK-----------TEELEGQIKK---------------LEADSLEVKASKEQAL 750
Query: 453 QMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEK 512
Q + + QL+TD E +K+L+ + + I R +K E +K+K
Sbjct: 751 QDLQQQR--QLNTDLELRATELSKQLEMEKE-------IVSSTRLDLQKKSEALESIKQK 801
Query: 513 QYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDI 572
+ + K +F TL + +E++ NN++ +
Sbjct: 802 LTKQEEEKQILKQDF---ETLSQETKIQHEEL-------------NNRIQTTVT------ 839
Query: 573 KLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAAN 632
+L + K E EA + +ST K + +++++ S+ ++N + KA+
Sbjct: 840 ELQKVKMEKEALMTELSTVKD-------KLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 633 LSE--KHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQI 690
+ KH L T+ E KKS +K + S + + Q+
Sbjct: 893 TCKELKHQLQVQMENTLKEQKEL------------KKSLEKEKEASHQLKLELNSMQEQL 940
Query: 691 RKASNTSKNISKAKQL----IEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERK---KL 743
+A NT K K +Q I + K + K E + L+ + +T E K +L
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 744 SETEDSVIIIDSSPTALKHP-EKNQKKL-QCLNDVLGKK-----LNTSTKNVPGKMKVAP 796
++ + + L++ EK+Q+ Q +D G++ K+V K+ +A
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
Query: 797 LFLVRKAQKAADPVPSFDE-------SSQDTSEKSQDCDVQCKAKRD 836
L+ + + E QD+++K Q +CKA +D
Sbjct: 1061 EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107
Score = 36.2 bits (82), Expect = 0.30
Identities = 87/485 (17%), Positives = 194/485 (40%), Gaps = 54/485 (11%)
Query: 78 LGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEIS 137
L K CK + + V E+ ++E K+K L +LN+++ +
Sbjct: 890 LEKTCK-ELKHQLQVQMENTLKEQKELKKSLE-KEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 138 SDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQ---------DTKSQPNTMTSLQNS 188
+ KE+ L + E S + KKQ+E L ++ + K Q + Q
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 189 KKVNPKQGTTKNDFKKLRK--RKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHA 246
K +N+++K ++ ++ + ES LA +L + K + E+ S+
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 247 NSRDNVTEAAQ-LNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYI 305
N N + Q L + T+ + + KE +++E + + +I K +
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQD---SAKKEQQLQE----------RCKALQDIQKEKSL 1114
Query: 306 SESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQ 365
E E + LA++ I ++ +I ++ + K ++E+ E T
Sbjct: 1115 KEKE--------LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI-----KEITNL 1161
Query: 366 KRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEER-QQFMK-AFRQPASDALKNGVKKSS 423
K ++IQ ++LEL G ++++K E+R QQ +K ++ + K ++K +
Sbjct: 1162 KDAKQLLIQ-QKLEL----QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Query: 424 DKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNK 483
++ EK + ++N K+ +Q+ + N NL + + + +L+K+
Sbjct: 1217 KLHSEIKEKEVGMKKHEENEAKLT----MQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 484 KTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYED 543
A+ + N ++ L E+ + + + +T+ + +N + ++
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRA---LLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE 1329
Query: 544 IANDD 548
+ ++
Sbjct: 1330 LGREN 1334
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 48.5 bits (114), Expect = 6e-05
Identities = 157/699 (22%), Positives = 247/699 (35%), Gaps = 107/699 (15%)
Query: 472 KEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSS 531
KEKNK KK+ K+T K RE K+ F E + ++ S + + SS
Sbjct: 449 KEKNKVKKKRKKET--------KGREVRFGKRSDKFCSSESESESSES-GEDDRDSLGSS 499
Query: 532 TLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIP-----------VKDIKLTQSKAE 580
LV +D + L SS ++ + + P + K S A
Sbjct: 500 GCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAW 559
Query: 581 SEASLLNVST-PKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHS- 638
SE S L+ ST + T S S + E+++ + + + +K A+LSEK S
Sbjct: 560 SEVSSLSDSTRTRLTSESDYSSEGSSVESLKPV---------RKRQEHRKRASLSEKKSP 610
Query: 639 -LYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTS 697
L +AE D E + K K +K EK + + SQ K + +
Sbjct: 611 FLSSAEGAVPKLDKEGKV--------VKKHKTKHKHKNKEKGQCS----ISQELKLKSFT 658
Query: 698 KNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSP 757
+KQ +KA L S TE L+ H E+ + E+ +
Sbjct: 659 YEYEDSKQKSDKAILLENDLS--TENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEK 716
Query: 758 TALKHPEKNQKKLQCLNDVLGK----KLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSF 813
+ + + N+ + + + + S K K + L+ + +K+ D PS
Sbjct: 717 SLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDR-PSK 775
Query: 814 DESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVY-NAVSTSFQRVVH 872
E D E D K K L K ++ ++ +A D Y N
Sbjct: 776 LEKKNDLKE-----DKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTK 830
Query: 873 VQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFS-----TLNSKLKSGN 927
DD W F +L+ D GE S T +KS +
Sbjct: 831 FSLSDDQRDRW------------FSDLSDSSFDFK------GEDSWDSPVTDYRDMKSDS 872
Query: 928 SAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQEL 987
A + + T KE ++E R + E +K L K E + +E H + +
Sbjct: 873 VAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKH--KSV 930
Query: 988 EADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRK-----SEELSKRNNSSGIKLD 1042
+S K+ KR+ E+ + RK E K K EEL + SG K
Sbjct: 931 PGYLSEKDKKRR--ESAEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDK 988
Query: 1043 SSKDSGTEDMLWTEKYQPQTASELIGNELAIK--------KLHSWLKDWKRRAELEERQN 1094
S D G W + + + G + K K S KD ++ LE+ Q
Sbjct: 989 SDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEKSSDKDKSEKSILEKCQK 1048
Query: 1095 -------LKGKRD--EKHEDFSG-GIDFKGSSDDEEESR 1123
K K+D EKH+D G + K S D +E +
Sbjct: 1049 DKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKK 1087
Score = 42.4 bits (98), Expect = 0.004
Identities = 101/548 (18%), Positives = 204/548 (37%), Gaps = 39/548 (7%)
Query: 14 PPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSN-ILDYFRKTSPT 72
PPV D + K +K+ +++ +I K + T++ AP K S+ IL
Sbjct: 359 PPVDDKHLLK-KDYRKETKSNSFISIPK-MEVKSYTKNNTIAPKKASHRILSDTSDEEDA 416
Query: 73 NEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEA 132
+ G++ ++ + +P ++ + + + KKKRK+ ++ K ++
Sbjct: 417 SVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKF 476
Query: 133 PIEISSDDSKEDYSLNNDFVESST----SVLRYKKQVEVLAENIQDTKSQPNTMTSLQNS 188
S +S E + D + SS S L K + + T S ++ QN
Sbjct: 477 CSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNP 536
Query: 189 KKVNPKQGTTKND-FKKLRKRKCRDVVDLSESLP--LAEELNLLKKDGKDTKQMENTTSH 245
+ + D +K + +V LS+S L E + +G + ++
Sbjct: 537 SHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDY-SSEGSSVESLKPVRKR 595
Query: 246 ANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYI 305
R + ++ ++ + K KE KV V K+
Sbjct: 596 QEHRKRAS-LSEKKSPFLSSAEGAVPKLDKEGKV-----------VKKHKTKHKHKN--- 640
Query: 306 SESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQ 365
E ISQ+++ K+ T + K + L + EN L ++++
Sbjct: 641 KEKGQCSISQELKLKSFTYEYE------DSKQKSDKAILLENDLSTENKLKVLKHDRDHF 694
Query: 366 KRKSNVV-IQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSD 424
K++ + ++ EE E + S + +K + + ++FR+ D K+ S
Sbjct: 695 KKEEKLSKMKLEEKEWLFKDEKSLKRIK-----DTNKDISRSFREE-KDRSNKAEKERSL 748
Query: 425 KQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKK 484
K+K E+ L + K S ++ + ++ +K KE +KLKK+
Sbjct: 749 KEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVY 808
Query: 485 TLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDI 544
D+ N+ + ++T F L + Q S + FK +++ Y D+
Sbjct: 809 REDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDM 868
Query: 545 ANDDLLKV 552
+D + K+
Sbjct: 869 KSDSVAKL 876
Score = 36.2 bits (82), Expect = 0.30
Identities = 107/526 (20%), Positives = 192/526 (36%), Gaps = 82/526 (15%)
Query: 198 TKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQ 257
T ++F+K K K ++ + P+ +E + D +D + H +D E
Sbjct: 319 TDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDD-KHLLKKDYRKETK- 376
Query: 258 LNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQV 317
++S I++ E +KS+ +N I S + S+T DE S + E +S
Sbjct: 377 -SNSFISIPKME-VKSYTKNNT--IAPKKASHRILSDTSDEEDASVTVGTGEKLRLS--- 429
Query: 318 RFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQT------VQKRKSNV 371
H I P + P +QK+ +N + ++T KR
Sbjct: 430 ----------AHTILPGSKTREPSNAKQQKE---KNKVKKKRKKETKGREVRFGKRSDKF 476
Query: 372 VIQEEELELAVL------EAGSSEAVKPK-CTLEERQQFMKAFRQPASDALKNGVKKSSD 424
E E E + GSS +K L++ F S + +K +
Sbjct: 477 CSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNP 536
Query: 425 KQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQL-------HTDKGSFLKE---- 473
D + K R DN K I + ++ S + + + ++ +GS ++
Sbjct: 537 SHTDQHTKHW----RTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPV 592
Query: 474 -------KNKKLKKKNKKTLDT--GAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQR- 523
K L +K L + GA+P ++EG KK T + + + + S+ Q
Sbjct: 593 RKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQCSISQEL 652
Query: 524 -----KTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSK 578
E+ S + L+ D++ ++ LKV L K+ KL++ K
Sbjct: 653 KLKSFTYEYEDSKQKSDKAILLENDLSTENKLKV--------LKHDRDHFKKEEKLSKMK 704
Query: 579 AESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHS 638
E + L K + RI T + + D + ++ + S ++ + EK
Sbjct: 705 LEEKEWLF-----KDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLR 759
Query: 639 LYTAELITVPFDSESPIR----MKFTRISTPKKSKKKSNKRSEKSE 680
LY E D S + +K +IS K+ K +K K E
Sbjct: 760 LYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKE 805
>gi|150456436 hypothetical protein LOC55719 isoform 1 [Homo sapiens]
Length = 1173
Score = 47.4 bits (111), Expect = 1e-04
Identities = 115/581 (19%), Positives = 210/581 (36%), Gaps = 96/581 (16%)
Query: 264 TVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVT 323
T +E L S KE+K + +P I E G E+ I + R
Sbjct: 86 TEQFERKLSSPKESKPKRVPPEKSPII-------EAFMKGVKEHHEDHGIHESRR----- 133
Query: 324 VLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVL 383
+ K K I++ + S + ++ ++RKS + E E
Sbjct: 134 ---PCLSLASKYLAKGTNIYVPSSYHLPKEMKSLKKKHRSPERRKSLFI--HENNEKNDR 188
Query: 384 EAGSSEA-VKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEK---CLYEVGR 439
+ G + A K + T+ E F + R +S ++ + + ++ L K L R
Sbjct: 189 DRGKTNADSKKQTTVAEADIFNNSSRSLSS---RSSLSRHHPEESPLGAKFQLSLASYCR 245
Query: 440 DDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGN 499
+ K++ + Q ++ + S +K K + ++ IPGKN N
Sbjct: 246 ERELKRLRKEQMEQRINSENSFS-EASSLSLKSSIERKYKPRQEQRKQNDIIPGKNNLSN 304
Query: 500 TQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNN 559
+ +S ++ ++ ++ ++ + ++ E K +S+ ++
Sbjct: 305 VE-------------NGHLSRKRSSSDSWEPTSAGSKQNKFPEK------RKRNSVDSDL 345
Query: 560 KLSRKTSIPVKDIKLTQSK------AESEASLLNVSTPKSTRRSGRISSTPTTETIRGID 613
K +R++ IP + + E + + TP R IS P+ ET
Sbjct: 346 KSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPSDET----- 400
Query: 614 SDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSN 673
D S + + N S HS ++ I V E+ ++ +S K
Sbjct: 401 -----DGSSAGLAPSNSGN-SGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEK------- 447
Query: 674 KRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALH-ISRSKVTEEIAIPLRRSS 732
S I+KASN KN + + EK L +SR +PL ++
Sbjct: 448 --------------SAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLVPL--NA 491
Query: 733 RHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLN---------T 783
++ LP KK E S S + KH E K + ++V K++ T
Sbjct: 492 KNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLRSEYGT 551
Query: 784 STKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKS 824
TK+ P ++V P + +D PS ESS +++ S
Sbjct: 552 PTKSPPAALEVVP--CIPSPAAPSDKAPSEGESSGNSNAGS 590
>gi|209915547 hypothetical protein LOC55719 isoform 2 [Homo sapiens]
Length = 1186
Score = 47.4 bits (111), Expect = 1e-04
Identities = 115/581 (19%), Positives = 210/581 (36%), Gaps = 96/581 (16%)
Query: 264 TVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVT 323
T +E L S KE+K + +P I E G E+ I + R
Sbjct: 86 TEQFERKLSSPKESKPKRVPPEKSPII-------EAFMKGVKEHHEDHGIHESRR----- 133
Query: 324 VLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVL 383
+ K K I++ + S + ++ ++RKS + E E
Sbjct: 134 ---PCLSLASKYLAKGTNIYVPSSYHLPKEMKSLKKKHRSPERRKSLFI--HENNEKNDR 188
Query: 384 EAGSSEA-VKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEK---CLYEVGR 439
+ G + A K + T+ E F + R +S ++ + + ++ L K L R
Sbjct: 189 DRGKTNADSKKQTTVAEADIFNNSSRSLSS---RSSLSRHHPEESPLGAKFQLSLASYCR 245
Query: 440 DDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGN 499
+ K++ + Q ++ + S +K K + ++ IPGKN N
Sbjct: 246 ERELKRLRKEQMEQRINSENSFS-EASSLSLKSSIERKYKPRQEQRKQNDIIPGKNNLSN 304
Query: 500 TQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNN 559
+ +S ++ ++ ++ ++ + ++ E K +S+ ++
Sbjct: 305 VE-------------NGHLSRKRSSSDSWEPTSAGSKQNKFPEK------RKRNSVDSDL 345
Query: 560 KLSRKTSIPVKDIKLTQSK------AESEASLLNVSTPKSTRRSGRISSTPTTETIRGID 613
K +R++ IP + + E + + TP R IS P+ ET
Sbjct: 346 KSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKEPSDET----- 400
Query: 614 SDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSN 673
D S + + N S HS ++ I V E+ ++ +S K
Sbjct: 401 -----DGSSAGLAPSNSGN-SGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEK------- 447
Query: 674 KRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALH-ISRSKVTEEIAIPLRRSS 732
S I+KASN KN + + EK L +SR +PL ++
Sbjct: 448 --------------SAIKKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLVPL--NA 491
Query: 733 RHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLN---------T 783
++ LP KK E S S + KH E K + ++V K++ T
Sbjct: 492 KNCALPVSKKDKERSSSKECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLRSEYGT 551
Query: 784 STKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKS 824
TK+ P ++V P + +D PS ESS +++ S
Sbjct: 552 PTKSPPAALEVVP--CIPSPAAPSDKAPSEGESSGNSNAGS 590
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,435,270
Number of Sequences: 37866
Number of extensions: 3083797
Number of successful extensions: 14903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 453
Number of HSP's that attempted gapping in prelim test: 13120
Number of HSP's gapped (non-prelim): 2321
length of query: 1844
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1727
effective length of database: 13,817,196
effective search space: 23862297492
effective search space used: 23862297492
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.