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Search of human proteins with 121949817
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
(871 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 1774 0.0
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 689 0.0
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 682 0.0
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 682 0.0
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 682 0.0
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 407 e-113
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 150 5e-36
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 150 5e-36
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 132 2e-30
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 124 3e-28
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 122 2e-27
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 84 4e-16
gi|29788755 SET binding factor 2 [Homo sapiens] 82 2e-15
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 79 1e-14
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 79 1e-14
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 77 5e-14
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 76 1e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 74 4e-13
gi|239735519 SET binding factor 1 [Homo sapiens] 74 6e-13
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 71 5e-12
gi|209863002 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862998 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862994 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|18860873 MAP-kinase activating death domain-containing protei... 59 3e-08
gi|209862987 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862983 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862979 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862975 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209862971 MAP-kinase activating death domain-containing prote... 59 3e-08
gi|209571517 MAP-kinase activating death domain-containing prote... 59 3e-08
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 1774 bits (4594), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK 60
MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK
Sbjct: 1 MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK 60
Query: 61 NPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSR 120
NPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSR
Sbjct: 61 NPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSR 120
Query: 121 VKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV 180
VKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV
Sbjct: 121 VKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV 180
Query: 181 LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCEN 240
LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCEN
Sbjct: 181 LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCEN 240
Query: 241 NSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSAL 300
NSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSAL
Sbjct: 241 NSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSAL 300
Query: 301 YYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLVLKIDDI 360
YYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLVLKIDDI
Sbjct: 301 YYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLVLKIDDI 360
Query: 361 FESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQT 420
FESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQT
Sbjct: 361 FESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQT 420
Query: 421 LERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVI 480
LERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVI
Sbjct: 421 LERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVI 480
Query: 481 PKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRL 540
PKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRL
Sbjct: 481 PKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRL 540
Query: 541 GCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELC 600
GCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELC
Sbjct: 541 GCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELC 600
Query: 601 RPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYP 660
RPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYP
Sbjct: 601 RPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYP 660
Query: 661 FTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVS 720
FTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVS
Sbjct: 661 FTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVS 720
Query: 721 DEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNM 780
DEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNM
Sbjct: 721 DEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNM 780
Query: 781 TVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAI 840
TVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAI
Sbjct: 781 TVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAI 840
Query: 841 QYLETIPESEPSGMNRILRSLGSKMKFLQKK 871
QYLETIPESEPSGMNRILRSLGSKMKFLQKK
Sbjct: 841 QYLETIPESEPSGMNRILRSLGSKMKFLQKK 871
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 689 bits (1777), Expect = 0.0
Identities = 431/983 (43%), Positives = 570/983 (57%), Gaps = 149/983 (15%)
Query: 20 NIKQKISQWEGR--------ANGISNPEKWCPKDFGVRYNC---HQEIRLKKNPIA---- 64
NIK KIS+WEG+ + E + P R + ++ KN +
Sbjct: 45 NIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTE 104
Query: 65 ----ERKSKNLDVTSRE-NVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCS 119
ER ++V ++ G D+++ + D S ++ F +++ V
Sbjct: 105 STEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRF---QNDPLSVLK 161
Query: 120 RVKEIESCKEDV---LDPETSLPPGNFYTSQILWKKIEA--LPPDKL-------LNLALE 167
+VK++E +D LDP+ PG Y+ K EA P+ L ++ +
Sbjct: 162 QVKKLEQALKDGSAGLDPQL---PGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVH 218
Query: 168 HCDSSEKELNFRVLDSSYGITK-----SLENIYSEPEGQECGPSINPLPKPRRTFRYLSE 222
D +E +++ G + SLEN+Y EG P INPLPKPRRTF++ E
Sbjct: 219 PSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGE 278
Query: 223 S------GVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKI-RGRSK-----RK 270
G+ KE+ + S L SS P P ++ GR K RK
Sbjct: 279 GDKDGKPGIGFRKEK---RNLPPLPSLPPPPLPSS--PPPSSVNRRLWTGRQKSSADHRK 333
Query: 271 SFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDII-YPTKENPYEDI---- 325
S+EFED+ +S++ R + + L T SE+N+YEDI+ P KENPYEDI
Sbjct: 334 SYEFEDL---LQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHG 390
Query: 326 --------------PVQPLPMWRSPSAWKLPP-------------------------AKS 346
P +P + + P + S
Sbjct: 391 RCLGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPS 450
Query: 347 AFKAPKLVLKIDDIF----ESKRGKKKVK---------------------------LHSY 375
P DDIF + + G+KK K + S
Sbjct: 451 KISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSMESN 510
Query: 376 TGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFE 435
+GK E S ++SD E K +RL ++ K+ P Y +L R+LIE QE+QLFE
Sbjct: 511 SGK----VTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFE 566
Query: 436 LFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTS 495
FVVVSL KK +G +Y+P++ QQFP K + +K ++ E++LK IP+FCFPD+KDW+P
Sbjct: 567 YFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQ 626
Query: 496 ELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEK 555
+ SETFSFVLTGEDGSR FGYC++LLP GKGKRLPEVYC+VSRLGCF+LFS+ILDEVEK
Sbjct: 627 QFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEVEK 686
Query: 556 RREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCL 615
RR +SPALV P MRSVMEAPFPA G+TI VK++LPG+G E IELCRPLDSRLEHVDF+ L
Sbjct: 687 RRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESL 746
Query: 616 FKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASM 675
F LSV HL+ V ASLLLERRVIF+A+ LS LSKC HA+VA +YPF WQHTYIPVLP +M
Sbjct: 747 FSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAM 806
Query: 676 IDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALM 735
+DIVCSPTPFLIG+LS SLP L++LP+EEVL+VDL +FL+++ DED ILP KLQ AL
Sbjct: 807 VDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866
Query: 736 QILEERNEILTQE-------QNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGER 788
ILE+RNE+ ++ ++ + LN +VSEAFVRFFVE+VGHYSL +T ER ER
Sbjct: 867 HILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREER 926
Query: 789 VFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPE 848
QRE FRK+ +S+S+RHFL++FMETQMF GFIQ+RELR+ KGLFE+RA +YLET+P
Sbjct: 927 TLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQEYLETLPS 986
Query: 849 SEPSGMNRILRSLGSKMKFLQKK 871
E SG+N+ L+ LG+KMKFL KK
Sbjct: 987 GEHSGVNKFLKGLGNKMKFLHKK 1009
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 682 bits (1760), Expect = 0.0
Identities = 355/603 (58%), Positives = 451/603 (74%), Gaps = 13/603 (2%)
Query: 281 RNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAW- 339
R NS + L NS S SE + P + + + + + L + SPS+
Sbjct: 535 RKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLN 594
Query: 340 --------KLPPAKSAFKAPKLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNE 391
+L ++ A + PKLV +I+ I+ +KRGKK++K S + E + E S +E
Sbjct: 595 EDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESE 654
Query: 392 SDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISY 451
SD++ K +RL +Q KR P Y+TLE +L+E QE++LFE FVVVSL+KKPS +Y
Sbjct: 655 SDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTY 714
Query: 452 IPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDG 511
+P+V QFP K D KQ ++ EERLK IP+FCFPD+KDW+P SE SETFSF+LTGEDG
Sbjct: 715 LPEVSYQFP-KLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDG 773
Query: 512 SRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSV 571
SR FGYC++LLP GKG RLPEVYC++SRLGCF LFSK+LDEVE+RR +S ALVYPFMRS+
Sbjct: 774 SRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL 833
Query: 572 MEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASL 631
ME+PFPAPG+TI VK++LPGAG+E +EL RP+DSRLEHVDF+CLF CLSV LIR+ ASL
Sbjct: 834 MESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASL 893
Query: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
LLERRVIFVA+ LSTLS C HAVVA LYPF+WQHT+IPVLPASMIDIVC PTPFL+G+LS
Sbjct: 894 LLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLS 953
Query: 692 CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNF 751
SLP+L++LP+EE L+V+L +D+F++++ DED +LP KLQAAL Q LE +NE+++Q+ +
Sbjct: 954 SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDS 1013
Query: 752 SQD---VTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFL 808
D TLN LVSE F+RFFVE VGHYSL +T +E+GER FQRE FRKS S+S+R FL
Sbjct: 1014 DSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFL 1073
Query: 809 DLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFL 868
++FME+QMFAGFIQDRELRK KGLFE R QYLE +P++E SGMN+ LR LG+KMKFL
Sbjct: 1074 EVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFL 1133
Query: 869 QKK 871
KK
Sbjct: 1134 HKK 1136
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 682 bits (1760), Expect = 0.0
Identities = 355/603 (58%), Positives = 451/603 (74%), Gaps = 13/603 (2%)
Query: 281 RNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAW- 339
R NS + L NS S SE + P + + + + + L + SPS+
Sbjct: 535 RKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLN 594
Query: 340 --------KLPPAKSAFKAPKLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNE 391
+L ++ A + PKLV +I+ I+ +KRGKK++K S + E + E S +E
Sbjct: 595 EDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESE 654
Query: 392 SDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISY 451
SD++ K +RL +Q KR P Y+TLE +L+E QE++LFE FVVVSL+KKPS +Y
Sbjct: 655 SDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTY 714
Query: 452 IPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDG 511
+P+V QFP K D KQ ++ EERLK IP+FCFPD+KDW+P SE SETFSF+LTGEDG
Sbjct: 715 LPEVSYQFP-KLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDG 773
Query: 512 SRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSV 571
SR FGYC++LLP GKG RLPEVYC++SRLGCF LFSK+LDEVE+RR +S ALVYPFMRS+
Sbjct: 774 SRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL 833
Query: 572 MEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASL 631
ME+PFPAPG+TI VK++LPGAG+E +EL RP+DSRLEHVDF+CLF CLSV LIR+ ASL
Sbjct: 834 MESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASL 893
Query: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
LLERRVIFVA+ LSTLS C HAVVA LYPF+WQHT+IPVLPASMIDIVC PTPFL+G+LS
Sbjct: 894 LLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLS 953
Query: 692 CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNF 751
SLP+L++LP+EE L+V+L +D+F++++ DED +LP KLQAAL Q LE +NE+++Q+ +
Sbjct: 954 SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDS 1013
Query: 752 SQD---VTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFL 808
D TLN LVSE F+RFFVE VGHYSL +T +E+GER FQRE FRKS S+S+R FL
Sbjct: 1014 DSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFL 1073
Query: 809 DLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFL 868
++FME+QMFAGFIQDRELRK KGLFE R QYLE +P++E SGMN+ LR LG+KMKFL
Sbjct: 1074 EVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFL 1133
Query: 869 QKK 871
KK
Sbjct: 1134 HKK 1136
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 682 bits (1760), Expect = 0.0
Identities = 355/603 (58%), Positives = 451/603 (74%), Gaps = 13/603 (2%)
Query: 281 RNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAW- 339
R NS + L NS S SE + P + + + + + L + SPS+
Sbjct: 115 RKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLN 174
Query: 340 --------KLPPAKSAFKAPKLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNE 391
+L ++ A + PKLV +I+ I+ +KRGKK++K S + E + E S +E
Sbjct: 175 EDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESE 234
Query: 392 SDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISY 451
SD++ K +RL +Q KR P Y+TLE +L+E QE++LFE FVVVSL+KKPS +Y
Sbjct: 235 SDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTY 294
Query: 452 IPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDG 511
+P+V QFP K D KQ ++ EERLK IP+FCFPD+KDW+P SE SETFSF+LTGEDG
Sbjct: 295 LPEVSYQFP-KLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDG 353
Query: 512 SRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSV 571
SR FGYC++LLP GKG RLPEVYC++SRLGCF LFSK+LDEVE+RR +S ALVYPFMRS+
Sbjct: 354 SRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL 413
Query: 572 MEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASL 631
ME+PFPAPG+TI VK++LPGAG+E +EL RP+DSRLEHVDF+CLF CLSV LIR+ ASL
Sbjct: 414 MESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASL 473
Query: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
LLERRVIFVA+ LSTLS C HAVVA LYPF+WQHT+IPVLPASMIDIVC PTPFL+G+LS
Sbjct: 474 LLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLS 533
Query: 692 CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNF 751
SLP+L++LP+EE L+V+L +D+F++++ DED +LP KLQAAL Q LE +NE+++Q+ +
Sbjct: 534 SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDS 593
Query: 752 SQD---VTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFL 808
D TLN LVSE F+RFFVE VGHYSL +T +E+GER FQRE FRKS S+S+R FL
Sbjct: 594 DSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFL 653
Query: 809 DLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFL 868
++FME+QMFAGFIQDRELRK KGLFE R QYLE +P++E SGMN+ LR LG+KMKFL
Sbjct: 654 EVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFL 713
Query: 869 QKK 871
KK
Sbjct: 714 HKK 716
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 407 bits (1047), Expect = e-113
Identities = 206/422 (48%), Positives = 283/422 (67%), Gaps = 8/422 (1%)
Query: 431 QQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD 490
Q FE +VVSL+KK S Y P + QFP +++ Q ++ E LK IP FCFPD +
Sbjct: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
Query: 491 WMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKIL 550
W +E ETFSFVLT DGSR GYC++LLP G G RLP+VYC++S +GCF LFSKIL
Sbjct: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
Query: 551 DEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHV 610
DEVEKR ++S A++YPFM+ + EA FPAPG+T+T+KS++P +G E I L RPLDS LEHV
Sbjct: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
Query: 611 DFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPV 670
DF L CLS ++++ AS +LER++IF+A LSTLS+C HA A LYPF+W HTYIPV
Sbjct: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
Query: 671 LPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKL 730
+P S++ VC PTPF++G+ ++ D P+EEVL+V+LC FL V DE +ILPPKL
Sbjct: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
Query: 731 QAALMQILEER-NEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERV 789
Q ++ L + NE+ T EQ +N VS FV+FFV++VGHY+ + G+
Sbjct: 351 QDDILDSLGQGINELKTAEQ-------INEHVSGPFVQFFVKIVGHYASYIKREANGQGH 403
Query: 790 FQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPES 849
FQ F K+ TS++ R F+ F++TQ+F+ FIQ+ E K+ G F+ + ++Y E +
Sbjct: 404 FQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQK 463
Query: 850 EP 851
+P
Sbjct: 464 KP 465
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 150 bits (379), Expect = 5e-36
Identities = 117/414 (28%), Positives = 206/414 (49%), Gaps = 49/414 (11%)
Query: 426 IELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCF 485
I+ + FE++V V+ + +S P+V +QFP + +E L+ + KFCF
Sbjct: 5 IKQNPETTFEVYVEVAYPRTGGTLSD-PEVQRQFP--------EDYSDQEVLQTLTKFCF 55
Query: 486 PDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNL 545
P D + S++ + F+FVLT D + FG+C+ + G + +C++S L F +
Sbjct: 56 PFYVDSLTVSQV-GQNFTFVLTDIDSKQRFGFCR----LSSGAK--SCFCILSYLPWFEV 108
Query: 546 FSKIL----DEVEKRREMSPALVYPFMRSVMEAPFPAPGRTI--TVKSYLPGAGDESIEL 599
F K+L D KR+E + ++ + P P PG ++ +V SY ++
Sbjct: 109 FYKLLNILADYTTKRQENQ---WNELLETLHKLPIPDPGVSVHLSVHSYF------TVPD 159
Query: 600 CRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLY 659
R L S E+ + F + V +++ + AS+L ERR++ + + LSTL+ C H A LY
Sbjct: 160 TRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLY 219
Query: 660 PFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEV 719
P WQH YIPVLP ++D C+P P+LIGI + +++++ +++V+I+++ + L+
Sbjct: 220 PMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNT-LETP 278
Query: 720 SDEDEILPPKLQAALMQILEERNEILTQEQNFSQDV--TLNSLVSEAFVRFFVELVGHYS 777
D+ + LP N++++ +N + V T V+ AF++ G Y
Sbjct: 279 FDDLQSLP--------------NDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYR 324
Query: 778 LNMTVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDR-ELRKSG 830
+ + F E F + S ++R FL + Q+F FI R +L SG
Sbjct: 325 NALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSG 378
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 150 bits (379), Expect = 5e-36
Identities = 117/414 (28%), Positives = 206/414 (49%), Gaps = 49/414 (11%)
Query: 426 IELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCF 485
I+ + FE++V V+ + +S P+V +QFP + +E L+ + KFCF
Sbjct: 5 IKQNPETTFEVYVEVAYPRTGGTLSD-PEVQRQFP--------EDYSDQEVLQTLTKFCF 55
Query: 486 PDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNL 545
P D + S++ + F+FVLT D + FG+C+ + G + +C++S L F +
Sbjct: 56 PFYVDSLTVSQV-GQNFTFVLTDIDSKQRFGFCR----LSSGAK--SCFCILSYLPWFEV 108
Query: 546 FSKIL----DEVEKRREMSPALVYPFMRSVMEAPFPAPGRTI--TVKSYLPGAGDESIEL 599
F K+L D KR+E + ++ + P P PG ++ +V SY ++
Sbjct: 109 FYKLLNILADYTTKRQENQ---WNELLETLHKLPIPDPGVSVHLSVHSYF------TVPD 159
Query: 600 CRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLY 659
R L S E+ + F + V +++ + AS+L ERR++ + + LSTL+ C H A LY
Sbjct: 160 TRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLY 219
Query: 660 PFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEV 719
P WQH YIPVLP ++D C+P P+LIGI + +++++ +++V+I+++ + L+
Sbjct: 220 PMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNT-LETP 278
Query: 720 SDEDEILPPKLQAALMQILEERNEILTQEQNFSQDV--TLNSLVSEAFVRFFVELVGHYS 777
D+ + LP N++++ +N + V T V+ AF++ G Y
Sbjct: 279 FDDLQSLP--------------NDVISSLKNRLKKVSTTTGDGVARAFLKAQAAFFGSYR 324
Query: 778 LNMTVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDR-ELRKSG 830
+ + F E F + S ++R FL + Q+F FI R +L SG
Sbjct: 325 NALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSG 378
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 132 bits (331), Expect = 2e-30
Identities = 105/387 (27%), Positives = 189/387 (48%), Gaps = 36/387 (9%)
Query: 453 PQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGS 512
P V+ +FP +D G +E L+ +PKFCFP + + +++ + F+FVLT +
Sbjct: 29 PVVLWKFP--EDFGD------QEILQSVPKFCFPFDVERVSQNQV-GQHFTFVLTDIESK 79
Query: 513 RWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEK--RREMSPALVYPFMRS 570
+ FG+C+ + G + C++S L F ++ K+L+ + +E+ L +RS
Sbjct: 80 QRFGFCR----LTSGGTI--CLCILSYLPWFEVYYKLLNTLADYLAKELENDL-NETLRS 132
Query: 571 VMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCAS 630
+ P P + + + + L +SR + F + V +++++ AS
Sbjct: 133 LYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYAS 188
Query: 631 LLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGIL 690
+L ERR++ +++ LSTL+ C H A LYP WQH YIPVLP ++D C+P P+LIGI
Sbjct: 189 MLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIH 248
Query: 691 SCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQN 750
S + ++++ +E+V+++++ + SD + LP + +AL L++
Sbjct: 249 SSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN-LPSDVVSALKNKLKK---------- 297
Query: 751 FSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFLDL 810
Q V+ AF+R L G Y + F E F K H S ++ FL+
Sbjct: 298 --QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVK-HRSSVMKQFLET 354
Query: 811 FMETQMFAGFIQDRELRKSGVKGLFEI 837
+ Q+F FI R + + +G ++
Sbjct: 355 AINLQLFKQFIDGRLAKLNAGRGFSDV 381
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 124 bits (312), Expect = 3e-28
Identities = 106/408 (25%), Positives = 188/408 (46%), Gaps = 58/408 (14%)
Query: 453 PQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGS 512
P V+ +FP +D G +E L+ +PKFCFP + + +++ + F+FVLT +
Sbjct: 29 PVVLWKFP--EDFGD------QEILQSVPKFCFPFDVERVSQNQV-GQHFTFVLTDIESK 79
Query: 513 RWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEK--RREMSPALVYPFMRS 570
+ FG+C+ + G + C++S L F ++ K+L+ + +E+ L +RS
Sbjct: 80 QRFGFCR----LTSGGTI--CLCILSYLPWFEVYYKLLNTLADYLAKELENDL-NETLRS 132
Query: 571 VMEAPFPAPGRTITVKSYLPGAGDESIELCRP---------------------LDSRLEH 609
+ P P + + E C L + E
Sbjct: 133 LYNHPVPKANTPVNLS-----VNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLPTIPES 187
Query: 610 VDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIP 669
+ F + V +++++ AS+L ERR++ +++ LSTL+ C H A LYP WQH YIP
Sbjct: 188 RNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIP 247
Query: 670 VLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPK 729
VLP ++D C+P P+LIGI S + ++++ +E+V+++++ + SD + LP
Sbjct: 248 VLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN-LPSD 306
Query: 730 LQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERV 789
+ +AL L++ Q V+ AF+R L G Y +
Sbjct: 307 VVSALKNKLKK------------QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPIT 354
Query: 790 FQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEI 837
F E F K H S ++ FL+ + Q+F FI R + + +G ++
Sbjct: 355 FCEESFVK-HRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDV 401
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 122 bits (305), Expect = 2e-27
Identities = 108/398 (27%), Positives = 182/398 (45%), Gaps = 47/398 (11%)
Query: 446 PSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFV 505
P+ + P +++QFP +D +E ++++PKFCFP + P S F+F
Sbjct: 22 PASLQEDPPILRQFP-------PDFRD-QEAMQMVPKFCFPFDVEREPPSPAVQH-FTFA 72
Query: 506 LTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKIL---------DEVEKR 556
LT G+R FG+C+ L G L C++S L F +F K+L D+V +
Sbjct: 73 LTDLAGNRRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEA 126
Query: 557 REMSPALVYPFMRSVMEAPFPAPGRTITVKSYL----PGAGDESIELC--RPLDSRL--- 607
E+ L + + G +TV S P G+ C P RL
Sbjct: 127 EELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSI 186
Query: 608 -EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHT 666
E+ + L ++ +++ + A+LL ERRV+ A+ LSTL+ C HA A LYP W+H
Sbjct: 187 PENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHV 246
Query: 667 YIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEIL 726
IP LP ++D C+P P+LIG+ + ++++ +E+V+++++ A+ L+ ++ + L
Sbjct: 247 LIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANT-LETTFNDVQAL 305
Query: 727 PPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERG 786
PP + + L L R L + VS F++ L G Y + +
Sbjct: 306 PPDVVSLLR--LRLRKVALAPGEG----------VSRLFLKAQALLFGGYRDALVCSPGQ 353
Query: 787 ERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDR 824
F E F ++ F + Q+F FI+ R
Sbjct: 354 PVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEAR 391
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 84.3 bits (207), Expect = 4e-16
Identities = 104/398 (26%), Positives = 169/398 (42%), Gaps = 75/398 (18%)
Query: 491 WMPTSELKSETFS-FVLTGEDGSRWFG--------YCKKLLP-----------------V 524
W P ++ FS FVLTG + +G Y ++LL V
Sbjct: 8 WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
Query: 525 GKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSP------ALVYPFMRSVMEAPFPA 578
K + C++S F F K L + K P + FM+++ PFP+
Sbjct: 68 SKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI---PFPS 124
Query: 579 PGRT-ITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRV 637
P R I V+ + A S + PL L +F L L + + +LLE ++
Sbjct: 125 PQRPRILVQLSVHDALILSQPVSTPLP--LSGANFSTLLMNLGPENCATLLLFVLLESKI 182
Query: 638 IFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQL 697
+ + + L+ AVVA ++PF WQ YIP+ P S+ ++ +P PF++G+ S L
Sbjct: 183 LLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYF-DL 241
Query: 698 QDLPIEEVLIVDLCADKFLQEVSDED-----EILPPKLQAALMQILEERNEILTQ----- 747
D P ++V+ +DL D + VSDE + LP K L+ L++ L+
Sbjct: 242 HD-PPQDVVCIDL--DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKT 298
Query: 748 -----------EQNFSQDVTLNSL---VSEAFVRFFVELV-GHYSLNMTVTE-------R 785
E +FS + L + EAF+RF ++ G+ + +TE
Sbjct: 299 QEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATA 358
Query: 786 GERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQD 823
+ +F R+ F KS R+ F L +TQ+F FI++
Sbjct: 359 ADSLFDRQGFLKSR-DRAYAKFYTLLSKTQIFIRFIEE 395
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 82.0 bits (201), Expect = 2e-15
Identities = 112/442 (25%), Positives = 181/442 (40%), Gaps = 73/442 (16%)
Query: 432 QLFELFVVVSLQ-KKPSGISYIPQVIQQFPGKD--DHGYKQSKDMEERLKVIPKFCFPDS 488
+L + F+VV +KP + ++IQ+FP KD D + Q ++ FC P
Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIEL---------FCQPGG 53
Query: 489 KDWMPTSELKSETFSFV-LTGEDGSRWFGYC-------------KKLLPVGKGKR----- 529
W + E K TF V LT D R + C KK G+ K
Sbjct: 54 --WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQ 111
Query: 530 -----LPEVYCMVSRL-------GCFNL-FSKILDEVEKRREMSPALVYPFMRSVMEAPF 576
P+ +VSRL C L ++ +D + E + ++
Sbjct: 112 PAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLES-------LIANLCACLV 164
Query: 577 PAPGRTITVKSYLPGAGDESIELCRPLDSRLE--HVDFKCLFKCLSVCHLIRVCASLLLE 634
PA G + K + GAGD + + PL L LF+ L + +++ + ++L E
Sbjct: 165 PAAGGS--QKLFSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTE 221
Query: 635 RRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSL 694
+V+F + S LS A+ + ++P + + YIP+LPA +++++ SPTPF+IG+ S
Sbjct: 222 NKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFK 281
Query: 695 PQLQDLPIEEVLIVDLCADKF----LQEVSDEDEILPPKLQAALMQILEERNEILTQ--- 747
+ +L +V+I DL +S E L + Q+AL IL E+
Sbjct: 282 TDVHEL--LDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFP 339
Query: 748 --EQNFSQDVTLNSLVSEAFVRFFVELV-GHYSLNMTVTERGERV--FQREPFRKSHTSR 802
S L+ V F+R F +L G+ S + E V F + F
Sbjct: 340 PPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAF-LGQRGL 398
Query: 803 SVRHFLDLFMETQMFAGFIQDR 824
FL + FAGF+ +R
Sbjct: 399 VENDFLTKVLSGMAFAGFVSER 420
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 79.3 bits (194), Expect = 1e-14
Identities = 103/445 (23%), Positives = 184/445 (41%), Gaps = 81/445 (18%)
Query: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501
K + +SY +I ++P +D + + +P FC P W S+
Sbjct: 202 KTNTVSYKAGLICRYPQEDYESFSLPES-------VPLFCLPMGATIECWPSNSKYPLPV 254
Query: 502 FS-FVLTGEDGSRWFGYC--------------KKLLPVG-----------KGKRLPEVYC 535
FS FVLTG + +G K+ L +G K + C
Sbjct: 255 FSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCIC 314
Query: 536 MVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM----EAPFPAPGRTITVKSYLPG 591
++S F+ F K L + R +S V P + + + PFP+P R + P
Sbjct: 315 LLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP- 372
Query: 592 AGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSK 649
+++ L +P+ S L F L + L + + + + E +++ + S L+
Sbjct: 373 --HDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTS 430
Query: 650 CGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVD 709
A+V+ ++PF W Y+P+ P ++ D++ +P PF++GI S L D P +V VD
Sbjct: 431 VTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF-DLYD-PPPDVSCVD 488
Query: 710 LCADKFLQEVSDED----EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSL----- 760
+ + + ++ D+ +ILP K LM L ++ L + Q +D L L
Sbjct: 489 VDTNT-ISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDY 547
Query: 761 --------------VSEAFVRFFVELV-GHYSLNMTVTER-------GERVFQREPFRKS 798
+ EAF+ F ++ G+ S +T+ +F + F +S
Sbjct: 548 DFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS 607
Query: 799 HTSRSVRHFLDLFMETQMFAGFIQD 823
RS + F ++ +TQMF FI++
Sbjct: 608 R-DRSHQKFYNMMTKTQMFIRFIEE 631
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 79.3 bits (194), Expect = 1e-14
Identities = 103/445 (23%), Positives = 184/445 (41%), Gaps = 81/445 (18%)
Query: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501
K + +SY +I ++P +D + + +P FC P W S+
Sbjct: 202 KTNTVSYKAGLICRYPQEDYESFSLPES-------VPLFCLPMGATIECWPSNSKYPLPV 254
Query: 502 FS-FVLTGEDGSRWFGYC--------------KKLLPVG-----------KGKRLPEVYC 535
FS FVLTG + +G K+ L +G K + C
Sbjct: 255 FSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCIC 314
Query: 536 MVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM----EAPFPAPGRTITVKSYLPG 591
++S F+ F K L + R +S V P + + + PFP+P R + P
Sbjct: 315 LLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP- 372
Query: 592 AGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSK 649
+++ L +P+ S L F L + L + + + + E +++ + S L+
Sbjct: 373 --HDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTS 430
Query: 650 CGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVD 709
A+V+ ++PF W Y+P+ P ++ D++ +P PF++GI S L D P +V VD
Sbjct: 431 VTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF-DLYD-PPPDVSCVD 488
Query: 710 LCADKFLQEVSDED----EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSL----- 760
+ + + ++ D+ +ILP K LM L ++ L + Q +D L L
Sbjct: 489 VDTNT-ISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDY 547
Query: 761 --------------VSEAFVRFFVELV-GHYSLNMTVTER-------GERVFQREPFRKS 798
+ EAF+ F ++ G+ S +T+ +F + F +S
Sbjct: 548 DFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS 607
Query: 799 HTSRSVRHFLDLFMETQMFAGFIQD 823
RS + F ++ +TQMF FI++
Sbjct: 608 R-DRSHQKFYNMMTKTQMFIRFIEE 631
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 77.4 bits (189), Expect = 5e-14
Identities = 101/449 (22%), Positives = 180/449 (40%), Gaps = 88/449 (19%)
Query: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501
K + + Y +++ ++P +D+ + + +P FC P W ++
Sbjct: 205 KANTLVYEAELLGRYPEEDNEAFPLPES-------VPVFCLPMGATIECWPAQTKYPVPV 257
Query: 502 FS-FVLTGEDGSRWFGYCKKLLPV---------------------------GKGKRLPEV 533
FS FVLTG G + +G + G+ R
Sbjct: 258 FSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRA 317
Query: 534 YCMVSRLGCFNLFSKILDEVEKRREMSP------ALVYPFMRSVMEAPFPAPGRTITVKS 587
++SR F F L + + P A + F+ +V PFP+P R +
Sbjct: 318 IAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQ 374
Query: 588 YLPGAGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLS 645
P +++ LC+P+ S L F L + L I + ++L E +++ +
Sbjct: 375 MSPY---DNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPD 431
Query: 646 TLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEV 705
L+ A+V+ ++P WQ YIP+ P + D++ +P PF++GI S S L D P +V
Sbjct: 432 LLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHS-SYFDLHD-PPADV 489
Query: 706 LIVDLCADKFLQEVSDEDEILPPK---------LQAALMQILEERNEILT-QEQNFSQDV 755
+ VDL + Q ++E ++L P+ L A L + ++ ++ T E+ S +
Sbjct: 490 ICVDLDTNTLFQ--TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEF 547
Query: 756 TLNSL-------------VSEAFVRFFVELVGHYSLNMTVTERG--------ERVFQREP 794
L V AF+RF L+ Y + + + + +F +
Sbjct: 548 LLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQG 607
Query: 795 FRKSHTSRSVRHFLDLFMETQMFAGFIQD 823
F KS RS + TQMF+ FI++
Sbjct: 608 FLKSR-ERSSHKLYSQLLHTQMFSQFIEE 635
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 76.3 bits (186), Expect = 1e-13
Identities = 54/220 (24%), Positives = 103/220 (46%), Gaps = 17/220 (7%)
Query: 535 CMVSRLGCFNLFSKILDEVEKR---REMSPALVYPFMRSVM-EAPFPAPGRTITVKSYLP 590
C+++ L K L ++ K ++ P + ++ +++ E P P PGR++
Sbjct: 193 CLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVY- 251
Query: 591 GAGDESIELCRPLDSRLEHVDFKC--LFKCLSVCHLIRVCASLLLERRVIFVANSLSTLS 648
E + RP S L D+ F+ L + +L++V +LLE +++ + L
Sbjct: 252 ----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLM 307
Query: 649 KCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPI-EEVLI 707
+ L+PF WQH Y+P+LPAS++ + +P P+L+G+ S L + +E +
Sbjct: 308 TVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANL 367
Query: 708 VDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQ 747
+ D E+ +E P K + ++E +E+L Q
Sbjct: 368 CFVDIDNHFIELPEEFPQFPNK-----VDFIQELSEVLVQ 402
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 74.3 bits (181), Expect = 4e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 19/219 (8%)
Query: 535 CMVSRLGCFNLFSKILDEVEKR---REMSPALVYPFMRSVM-EAPFPAPGRTITVKS-YL 589
C+++ + +L+++ + + P + ++ +V+ E P P PGR++ Y
Sbjct: 208 CLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYG 267
Query: 590 PGAGDESIELCRPLDSRLEHVDF--KCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTL 647
P I RP + L DF K +F+ L V ++ ++ LLE +++ + L
Sbjct: 268 P------IICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRL 321
Query: 648 SKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPI-EEVL 706
+ A ++PF WQH Y+P+LPAS++ + +P P+L+G+ S L L + +E
Sbjct: 322 MTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEAN 381
Query: 707 IVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEIL 745
+ + D E+ ++ P KL + ++E +EIL
Sbjct: 382 LCFVDIDNHFIELPEDLPQFPNKL-----EFVQEVSEIL 415
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 73.9 bits (180), Expect = 6e-13
Identities = 61/251 (24%), Positives = 110/251 (43%), Gaps = 24/251 (9%)
Query: 591 GAGDESIELCRPLDSR-LEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSK 649
GAGD + DS + LF+ L + +++ + + L E +V+F++ S L+
Sbjct: 189 GAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLAD 248
Query: 650 CGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVD 709
++A L+P + TY+P+LPA +++++ +PTPF+IG+ + + Q+L +V++ D
Sbjct: 249 ACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQEL--LDVIVAD 306
Query: 710 LCADKFLQEVSDEDEILPPKLQAALMQILEE--RNEILTQEQNFSQDVTLNSLVS----- 762
L LP LQ+ +L E+ + F T S +
Sbjct: 307 LDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSLKMQDKE 366
Query: 763 --EAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRH-------FLDLFME 813
F+R F +L+ Y + V EP + H + + FL +E
Sbjct: 367 LRAVFLRLFAQLLQGYRWCLHVVR-----IHPEPVIRFHKAAFLGQRGLVEDDFLMKVLE 421
Query: 814 TQMFAGFIQDR 824
FAGF+ +R
Sbjct: 422 GMAFAGFVSER 432
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 70.9 bits (172), Expect = 5e-12
Identities = 98/430 (22%), Positives = 174/430 (40%), Gaps = 69/430 (16%)
Query: 477 LKVIPKFCFPDSKDWMPTSELKSETFSF-VLTGEDGSRWFG------------YC---KK 520
L +P+ CFP +E K + F VLT G+R +G YC K
Sbjct: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
Query: 521 LLPVGKGKRLPEVYCMVSRLGCFN----LFSKILDEVEKRREMS-PALVYPFMRSVMEAP 575
G +P C+VSR +N S +L ++ ++ + + F + P
Sbjct: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
Query: 576 FPAPGRTITVKSYLPGAGDESIELCRPL----DSRLEHVDFKCLFKCLSVCHLIRVCASL 631
P PG V + +S+++ P +S + +D C ++++ +
Sbjct: 157 SPPPGPLHLVFNM------KSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCI 210
Query: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
L E+R++F ++ + L+ +A LYP WQH ++P+L M+D V +PT FL+G
Sbjct: 211 LTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMG--- 267
Query: 692 CSLPQLQDLPIEE---VLI-VDLCADKFLQEVSDEDEILPPKLQAA-----LMQILEERN 742
C L +++ E VLI +D + + + D +I L AA +Q L+ +
Sbjct: 268 CHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHH 327
Query: 743 EILTQEQNFSQDV------------TLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVF 790
E+ S D+ LN + + ++ V + ++ RVF
Sbjct: 328 ELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVF 384
Query: 791 QREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESE 850
E F K+ F ++T MF F++ R R+ + A ++ +SE
Sbjct: 385 NSEEFLKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRR--------MDAFAQMDLDTQSE 435
Query: 851 PSGMNRILRS 860
+N +L S
Sbjct: 436 EDRINGMLLS 445
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
Query: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
Query: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,306,883
Number of Sequences: 37866
Number of extensions: 1802323
Number of successful extensions: 5913
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 5762
Number of HSP's gapped (non-prelim): 165
length of query: 871
length of database: 18,247,518
effective HSP length: 111
effective length of query: 760
effective length of database: 14,044,392
effective search space: 10673737920
effective search space used: 10673737920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.