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Search of human proteins with 121114294
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo
sapiens]
(803 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 1618 0.0
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 1507 0.0
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 1499 0.0
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 1499 0.0
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 1460 0.0
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 1460 0.0
gi|4759026 RAS protein activator like 1 [Homo sapiens] 729 0.0
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 335 1e-91
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 334 2e-91
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 132 2e-30
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 132 2e-30
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 117 4e-26
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 117 4e-26
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 115 2e-25
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 108 3e-23
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 108 3e-23
gi|38570146 synaptotagmin VII [Homo sapiens] 90 7e-18
gi|238550198 synaptotagmin III [Homo sapiens] 90 9e-18
gi|238550196 synaptotagmin III [Homo sapiens] 90 9e-18
gi|14150054 synaptotagmin III [Homo sapiens] 90 9e-18
gi|130502162 RAS protein activator like 3 [Homo sapiens] 86 1e-16
gi|209447073 synaptotagmin I [Homo sapiens] 86 2e-16
gi|5032139 synaptotagmin I [Homo sapiens] 86 2e-16
gi|209447070 synaptotagmin I [Homo sapiens] 86 2e-16
gi|45504376 synaptotagmin VI [Homo sapiens] 85 2e-16
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 84 5e-16
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 84 5e-16
gi|92859638 synaptotagmin V [Homo sapiens] 84 5e-16
gi|28376627 synaptotagmin IX [Homo sapiens] 82 2e-15
gi|13384594 protein kinase C, gamma [Homo sapiens] 81 3e-15
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 1618 bits (4190), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
Query: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660
LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE
Sbjct: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660
Query: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720
LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
Sbjct: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720
Query: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780
LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
Sbjct: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780
Query: 781 EAHSSSPAGSPPSEPNCLLELQT 803
EAHSSSPAGSPPSEPNCLLELQT
Sbjct: 781 EAHSSSPAGSPPSEPNCLLELQT 803
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 1507 bits (3901), Expect = 0.0
Identities = 757/803 (94%), Positives = 757/803 (94%), Gaps = 46/803 (5%)
Query: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
Query: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660
LSFAKTPSS KCVNE
Sbjct: 601 LSFAKTPSS----------------------------------------------KCVNE 614
Query: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720
LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
Sbjct: 615 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 674
Query: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780
LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
Sbjct: 675 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 734
Query: 781 EAHSSSPAGSPPSEPNCLLELQT 803
EAHSSSPAGSPPSEPNCLLELQT
Sbjct: 735 EAHSSSPAGSPPSEPNCLLELQT 757
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 1499 bits (3881), Expect = 0.0
Identities = 754/803 (93%), Positives = 755/803 (94%), Gaps = 46/803 (5%)
Query: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
Query: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660
LSFAKTPSS KCVNE
Sbjct: 601 LSFAKTPSS----------------------------------------------KCVNE 614
Query: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720
LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
Sbjct: 615 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 674
Query: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780
LDHDLEAQLI RHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
Sbjct: 675 LDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 734
Query: 781 EAHSSSPAGSPPSEPNCLLELQT 803
EAHSSSPAGSPPSEPNCLLELQT
Sbjct: 735 EAHSSSPAGSPPSEPNCLLELQT 757
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 1499 bits (3881), Expect = 0.0
Identities = 754/803 (93%), Positives = 755/803 (94%), Gaps = 46/803 (5%)
Query: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
Query: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360
ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540
SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
Query: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660
LSFAKTPSS KCVNE
Sbjct: 601 LSFAKTPSS----------------------------------------------KCVNE 614
Query: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720
LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
Sbjct: 615 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 674
Query: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780
LDHDLEAQLI RHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
Sbjct: 675 LDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 734
Query: 781 EAHSSSPAGSPPSEPNCLLELQT 803
EAHSSSPAGSPPSEPNCLLELQT
Sbjct: 735 EAHSSSPAGSPPSEPNCLLELQT 757
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 1460 bits (3779), Expect = 0.0
Identities = 728/731 (99%), Positives = 729/731 (99%)
Query: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
Query: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
Query: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
Query: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
Query: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
Query: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 612
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
Query: 613 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 672
ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
Query: 673 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 732
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
Query: 733 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 792
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
Query: 793 SEPNCLLELQT 803
SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731
Score = 43.5 bits (101), Expect = 8e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
Query: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
A+ D D +SR+D +GKV +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 1460 bits (3779), Expect = 0.0
Identities = 728/731 (99%), Positives = 729/731 (99%)
Query: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
Query: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
Query: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372
LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
Query: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
Query: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
Query: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552
DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
Query: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 612
DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
Query: 613 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 672
ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
Query: 673 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 732
INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
Query: 733 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 792
HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
Query: 793 SEPNCLLELQT 803
SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731
Score = 43.5 bits (101), Expect = 8e-04
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)
Query: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L
Sbjct: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
Query: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
A+ D D +SR+D +GKV +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 729 bits (1882), Expect = 0.0
Identities = 388/794 (48%), Positives = 522/794 (65%), Gaps = 19/794 (2%)
Query: 1 MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1 MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
Query: 61 LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
LP FH +AFYV+DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI
Sbjct: 61 LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
L +++ + LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W
Sbjct: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180
Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
+E E GA L VE WDWD+V +NDFLG V + L+ + +GWFRL P +
Sbjct: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-R 238
Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIE 295
+ GNLG+L+++VRL ++ VLPS YQPL+ LL V QGP + + L+E
Sbjct: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294
Query: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESF 355
E T +CRQD+AT L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKSME F
Sbjct: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354
Query: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
+K+ GM YLH VL P+I++VFEEKKY+ELDP K+++ +E ++ E S
Sbjct: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414
Query: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
L +LG ++ A+ SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474
Query: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQG 535
+PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q
Sbjct: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534
Query: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
V++++DF+ +LVD++ + R L + V+EG L + + G +FKK Y
Sbjct: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594
Query: 596 LTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQC 655
L+ E LSF+K+P + I +++IRA E+V+E +F HVMQV+ D G T YLQC
Sbjct: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654
Query: 656 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 715
K VNELNQWLSALRK S N L + HPG FR +W+CC Q E++ GC +T S VTL
Sbjct: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714
Query: 716 EWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 769
+W+DPLD D EAQ + R LL L R + L T+ G PE +
Sbjct: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772
Query: 770 ARLLRVLQDLREAH 783
ARLL VL DL AH
Sbjct: 773 ARLLEVLADLDRAH 786
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 335 bits (859), Expect = 1e-91
Identities = 237/792 (29%), Positives = 386/792 (48%), Gaps = 66/792 (8%)
Query: 6 SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
SL +I E KNL P D +C + +D E + RT V K+L PF+ EE+ +P T
Sbjct: 39 SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98
Query: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
F ++FYV D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L
Sbjct: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157
Query: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
+ + C+ ++A P + DP+ V G +R +T + KK+
Sbjct: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217
Query: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
P++NE F +F+++E +E L ++ W+ + ++ FLG++ + V
Sbjct: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277
Query: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
LR + W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL
Sbjct: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337
Query: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
+ L E + D L++L L F + +L+L T + NT
Sbjct: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394
Query: 341 LFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
+FR NSLA++ ++ +K+ G YL L PI++++ + K E+DP K++
Sbjct: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444
Query: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
E + +E + + LR ++ L + + +S +CP V+ F L + +RFP H
Sbjct: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498
Query: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
V + AV+SF+ LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++
Sbjct: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
Query: 518 SRAKEAWM-EPLQPTVRQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
S KE +M E + +G + +K F+ ++ E K+ + L KEG ++
Sbjct: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612
Query: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSH 635
R +G+ + +FKK +F LT+ L++ K P I + NI A EK+EE SF +
Sbjct: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672
Query: 636 VMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCC 695
+ QVI+T+ + Y+Q E N+W+ L +VS N L YHP V+ W CC
Sbjct: 673 MFQVIHTE-----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCC 727
Query: 696 HQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAG 755
+ + GC + V D +D D E + I L + + ++ E G
Sbjct: 728 QETGENTLGCKPCTAGVPADIQID-IDEDRETERI-YSLFTLSLLKLQKMEEACGTI--- 782
Query: 756 TVPTSPGKVPED 767
V P K P+D
Sbjct: 783 AVYQGPQKEPDD 794
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 334 bits (857), Expect = 2e-91
Identities = 230/732 (31%), Positives = 363/732 (49%), Gaps = 67/732 (9%)
Query: 6 SLYIRIVEGKNLPAKDITGSS---DPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP 62
S+ I+I E KNLP+ G S D YC V +D E + RT V K+LCPF+GE++ +P
Sbjct: 13 SVKIKIGEAKNLPS--YPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIP 70
Query: 63 PTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
+F ++FY+ D D RD +IGKV + ++ + + + W L VD D EVQG++HL
Sbjct: 71 RSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHL 129
Query: 123 RLEVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVK 173
L + G +L ++E + L NG DP+ V ++ ++T + +
Sbjct: 130 ELRLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKR 187
Query: 174 KSCYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVV 216
K+ P+++E F FE+ +E ++ L + W+ L ++FLG++
Sbjct: 188 KTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELR 247
Query: 217 IDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLL 276
I ++ LR E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL
Sbjct: 248 IPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLL 307
Query: 277 CHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTS 336
+ L E +Q+ A L++LFL G F+ + E+ RT
Sbjct: 308 LKSADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQ 364
Query: 337 ETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGC 396
+ NT+FR NSLASK ++ +K+AGM YLH L P I ++ + K E+DP K++
Sbjct: 365 DPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK------ 418
Query: 397 SGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGA 456
+ E LE + + LR ++ + A++ S +CP V+ F L +RF
Sbjct: 419 --------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--Q 468
Query: 457 QHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTP 516
+V + AV+SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++
Sbjct: 469 DDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKS 528
Query: 517 ASRA-KEAWMEPLQP--TVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPL 573
S + KE++M ++ +K+F+ + +D +++ + L KEG
Sbjct: 529 KSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-F 582
Query: 574 FIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGG 633
I R +G+ +FKK +F LT ++ K+ + I + NI A EK+EE+SF
Sbjct: 583 MIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKM 642
Query: 634 SHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWS 693
++ QVI + A Y+Q E W+ L KVS N L YHP + W
Sbjct: 643 KNMFQVIQPERA-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWL 697
Query: 694 CCHQKEKTGQGC 705
CC + GC
Sbjct: 698 CCRAPSDSAPGC 709
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 132 bits (331), Expect = 2e-30
Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)
Query: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359
Query: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 227
W E FEF + ++ V + D+ + N+++G V I + Q
Sbjct: 360 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 410
Query: 228 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 286
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 411 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 462
Query: 287 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 345
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N
Sbjct: 463 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 519
Query: 346 SLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 405
++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS
Sbjct: 520 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 565
Query: 406 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 465
+E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 566 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 622
Query: 466 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 623 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667
Score = 32.3 bits (72), Expect = 1.8
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 132 bits (331), Expect = 2e-30
Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)
Query: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
Query: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 227
W E FEF + ++ V + D+ + N+++G V I + Q
Sbjct: 212 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 262
Query: 228 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 286
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 263 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 314
Query: 287 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 345
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N
Sbjct: 315 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 371
Query: 346 SLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 405
++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS
Sbjct: 372 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 417
Query: 406 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 465
+E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 418 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 474
Query: 466 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 475 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
Score = 32.3 bits (72), Expect = 1.8
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 117 bits (293), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143
Query: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200
Query: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252
Query: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312
Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357
Query: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413
Query: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471
Query: 547 VDIEE-------KDELDLQRTLS 562
+ E + +DL R LS
Sbjct: 472 SNPETLSNTAGFEGYIDLGRELS 494
Score = 34.7 bits (78), Expect = 0.36
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 91 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145
Query: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
V ++ E R+ +G V L ++A
Sbjct: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 117 bits (293), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
Query: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
Query: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
Query: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
Query: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
Query: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
Query: 547 VDIEE-------KDELDLQRTLS 562
+ E + +DL R LS
Sbjct: 568 SNPETLSNTAGFEGYIDLGRELS 590
Score = 34.7 bits (78), Expect = 0.36
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241
Query: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
V ++ E R+ +G V L ++A
Sbjct: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 115 bits (287), Expect = 2e-25
Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)
Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
L+ ++EAR+L PK R D + R + R S W E FEF
Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
Query: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240
A+ AL + + D D + D ++G V + V L E W+ +
Sbjct: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
Query: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290
S +G +++L+ R + ++LP Y+ + + ++ L
Sbjct: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
Query: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349
++E + + +++VA+ L+ + G AKDFL + E+ R E L FR N+LA+
Sbjct: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
Query: 350 KSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409
K++E ++++ G +YL +G I ++E ++ E+DP K C+ A L
Sbjct: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
Query: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469
+ LR L + S P ++ F R ER E++ +++
Sbjct: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
Query: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519
L LRF PAIMSP LF L + + D +TSRTL L+AK +QN+ N S+
Sbjct: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 108 bits (269), Expect = 3e-23
Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)
Query: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
Query: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366
A+ LL++FL + L L L E+S E TLFR+ +LAS ME ++K Q++H
Sbjct: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
Query: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
Query: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P ++ ++ F
Sbjct: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
Query: 543 ------ITKLVDIEEKDELDLQRTLS 562
+ +L D E DL R L+
Sbjct: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 108 bits (269), Expect = 3e-23
Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)
Query: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
GSL++ R E ++P Y L+ + + S C QD +
Sbjct: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575
Query: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366
A+ LL++FL + L L L E+S E TLFR+ +LAS ME ++K Q++H
Sbjct: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635
Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
L I K+ E K+ EL PSK+E + T HL +LS
Sbjct: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677
Query: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P
Sbjct: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735
Query: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P ++ ++ F
Sbjct: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793
Query: 543 ------ITKLVDIEEKDELDLQRTLS 562
+ +L D E DL R L+
Sbjct: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 90.1 bits (222), Expect = 7e-18
Identities = 67/229 (29%), Positives = 118/229 (51%), Gaps = 18/229 (7%)
Query: 3 KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVH 60
+ S+L ++I++ + LPAKD +G+SDP+ + + D + + T K L P W E +
Sbjct: 148 QESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFE 207
Query: 61 LPPTFHAVA----FYVMDEDALSRDDVIGKVCLTRDTI-ASHPKGFSGWAHLTEVDPDEE 115
P V V+D D SR+D IG+V + + + + + F W L
Sbjct: 208 GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTF--WKDLKPCSDGSG 265
Query: 116 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--RYKGR---TRETS 170
+GE+ L L P A + + ++++AR+L D GTSDP+V+V YK + ++T
Sbjct: 266 SRGELLLSLCYNPSANS--IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTV 323
Query: 171 IVKKSCYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 217
+K++ P +NE+F F++ + + + D D +SRND +GK+ +
Sbjct: 324 TMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372
Score = 70.5 bits (171), Expect = 6e-12
Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 8/116 (6%)
Query: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE---L 188
L +++A++L KD +GTSDPFV++ K ET + +K+ P WNETF FE
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 189 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQP--DQSKSR 242
++ L ++ D+D SRND +G+V I + ++ + Q + W L+P D S SR
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267
Score = 53.5 bits (127), Expect = 8e-07
Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 13/96 (13%)
Query: 5 SSLYIRIVEGKNLPAKDITGSSDPYCIV-------KVDNEPIIRTATVWKTLCPFWGEEY 57
+S+ + I++ +NL A DI G+SDPY V +V+ + +T T+ + L P + E +
Sbjct: 281 NSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKK---KTVTMKRNLNPIFNESF 337
Query: 58 QVHLPPTF---HAVAFYVMDEDALSRDDVIGKVCLT 90
+P + VMD+D LSR+DVIGK+ L+
Sbjct: 338 AFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLS 373
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 89.7 bits (221), Expect = 9e-18
Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
L +RI++ +LPAKD G SDPY + + D + +T KTL P + E +Q +P
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375
Query: 65 FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
A + F V D D SR D+IG+V L +A P W + E ++ GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
+ L P A RL ++++A +L D G SDP+V+ +GR R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
P +NE F++ ++E L + D+D + N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
+L+A DL KD NG SDP+V++ + + +T + +K+ P +NETF+F L E A
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379
Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
L +D+D SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 89.7 bits (221), Expect = 9e-18
Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
L +RI++ +LPAKD G SDPY + + D + +T KTL P + E +Q +P
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375
Query: 65 FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
A + F V D D SR D+IG+V L +A P W + E ++ GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
+ L P A RL ++++A +L D G SDP+V+ +GR R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
P +NE F++ ++E L + D+D + N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
+L+A DL KD NG SDP+V++ + + +T + +K+ P +NETF+F L E A
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379
Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
L +D+D SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 89.7 bits (221), Expect = 9e-18
Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
L +RI++ +LPAKD G SDPY + + D + +T KTL P + E +Q +P
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375
Query: 65 FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
A + F V D D SR D+IG+V L +A P W + E ++ GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
+ L P A RL ++++A +L D G SDP+V+ +GR R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493
Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
P +NE F++ ++E L + D+D + N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533
Score = 59.7 bits (143), Expect = 1e-08
Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
+L+A DL KD NG SDP+V++ + + +T + +K+ P +NETF+F L E A
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379
Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
L +D+D SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)
Query: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
+L+ +R R VLPS Y+ L L +L +E + ++++A +
Sbjct: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466
Query: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHGVLG 369
+++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG
Sbjct: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526
Query: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
++ ++ + E+DPSK C P+ +A LR + +
Sbjct: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571
Query: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
S PA + F +ER G++ + + F LR PAI++P LF L
Sbjct: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627
Query: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITK--LV 547
H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V
Sbjct: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685
Query: 548 DIE 550
D++
Sbjct: 686 DVD 688
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 3 KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
+ + L + I++ LPA D+ G+SDPY VKV D + T KTL P + E++
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 59 VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
+P + + V D D S+ D+IG+ + +T+ W L + +E
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271
Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
E G+I L P A +L +LEA++L D G SDP+V++ + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329
Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
+I K + P +NE+F FE+ ++ + V D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
E +EE G++ L+ + +L +++A +L D GTSDP+V+V K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192
Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
ET + +K+ P +NE F F++ + + L + +D+D S++D +G+ + + +
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252
Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
E W LQ + + ++ LG + +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 3 KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
+ + L + I++ LPA D+ G+SDPY VKV D + T KTL P + E++
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 59 VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
+P + + V D D S+ D+IG+ + +T+ W L + +E
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271
Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
E G+I L P A +L +LEA++L D G SDP+V++ + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329
Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
+I K + P +NE+F FE+ ++ + V D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
E +EE G++ L+ + +L +++A +L D GTSDP+V+V K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192
Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
ET + +K+ P +NE F F++ + + L + +D+D S++D +G+ + + +
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252
Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
E W LQ + + ++ LG + +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 2e-16
Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)
Query: 3 KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
+ + L + I++ LPA D+ G+SDPY VKV D + T KTL P + E++
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 59 VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
+P + + V D D S+ D+IG+ + +T+ W L + +E
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271
Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
E G+I L P A +L +LEA++L D G SDP+V++ + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329
Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
+I K + P +NE+F FE+ ++ + V D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
E +EE G++ L+ + +L +++A +L D GTSDP+V+V K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192
Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
ET + +K+ P +NE F F++ + + L + +D+D S++D +G+ + + +
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252
Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
E W LQ + + ++ LG + +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 85.1 bits (209), Expect = 2e-16
Identities = 70/223 (31%), Positives = 110/223 (49%), Gaps = 19/223 (8%)
Query: 6 SLYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
+L +RI++ +LPAKD GSSDPY + + D + ++T KTL P + E + H P
Sbjct: 160 TLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENF--HFPV 217
Query: 64 TFHAVA-----FYVMDEDALSRDDVIGKVCLTRDTIASH-PKGFSGWAHLTEVDPDEEVQ 117
+ +A V D D SR D+IG+V L AS + S W + +
Sbjct: 218 PYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDL 277
Query: 118 GEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIV 172
GEI L P A RL +V++ R+L D G SDP+V+V + + ++T+I
Sbjct: 278 GEIMFSLCYLP--TAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK 335
Query: 173 KKSCYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
K + P +NE F++ M+ +L + D+D V N+ +G
Sbjct: 336 KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIG 378
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/85 (32%), Positives = 51/85 (60%), Gaps = 5/85 (5%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFEL--QEGAM 193
+L+A DL KD G+SDP+V++ + +T + +K+ P ++E F F + +E A
Sbjct: 165 ILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELAD 224
Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
L + +D+D SR+D +G+V++D
Sbjct: 225 RKLHLSVFDFDRFSRHDMIGEVILD 249
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 84.0 bits (206), Expect = 5e-16
Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 193
V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236
Query: 194 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
+ L VE WDWDL SRNDF+G + + L+ +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277
Score = 38.1 bits (87), Expect = 0.033
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPII----RTATVWKTLCPFWGEEYQV 59
R L + + + KNL D G SDPY +K+ +P +T T+ +L P W E ++
Sbjct: 170 RDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229
Query: 60 HLPPT--FHAVAFYVMDEDALSRDDVIGKV 87
L + ++ + D D SR+D +G +
Sbjct: 230 QLKESDKDRRLSVEIWDWDLTSRNDFMGSL 259
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 84.0 bits (206), Expect = 5e-16
Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)
Query: 139 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 193
V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236
Query: 194 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
+ L VE WDWDL SRNDF+G + + L+ +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277
Score = 38.1 bits (87), Expect = 0.033
Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPII----RTATVWKTLCPFWGEEYQV 59
R L + + + KNL D G SDPY +K+ +P +T T+ +L P W E ++
Sbjct: 170 RDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229
Query: 60 HLPPT--FHAVAFYVMDEDALSRDDVIGKV 87
L + ++ + D D SR+D +G +
Sbjct: 230 QLKESDKDRRLSVEIWDWDLTSRNDFMGSL 259
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 84.0 bits (206), Expect = 5e-16
Identities = 68/224 (30%), Positives = 109/224 (48%), Gaps = 16/224 (7%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
L + I++ L A D+ GSSDPY V + D T +TL P +GE + +P
Sbjct: 125 LLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYV 184
Query: 65 F---HAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQ-GEI 120
+ V D D SR+D IG+V + ++ + W L +E+ + G+I
Sbjct: 185 ELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSV-DLGRPVQAWRELQAAPREEQEKLGDI 243
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKS 175
L P A +L VLEA++L D G SDP+V+V K R ++T+I K +
Sbjct: 244 CFSLRYVPTAG--KLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNT 301
Query: 176 CYPRWNETFEFELQEGAMEALCVE--AWDWDLVSRNDFLGKVVI 217
P +NE F FE+ ++ + VE D+D + +N+ +G+V +
Sbjct: 302 LNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAV 345
Score = 58.9 bits (141), Expect = 2e-08
Identities = 39/129 (30%), Positives = 67/129 (51%), Gaps = 9/129 (6%)
Query: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFELQ- 189
+L +L+A LA D G+SDP+VRV K R ET + +++ P + ETF F++
Sbjct: 124 QLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPY 183
Query: 190 -EGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
E L + +D+D SRND +G+V + + + + + + W LQ + R ++
Sbjct: 184 VELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQ----AAPREEQEK 239
Query: 249 LGSLQLEVR 257
LG + +R
Sbjct: 240 LGDICFSLR 248
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 82.4 bits (202), Expect = 2e-15
Identities = 66/220 (30%), Positives = 107/220 (48%), Gaps = 15/220 (6%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
L ++I + NLPAKD +G+SDPY + + D + +T KTL P + E + +P
Sbjct: 237 LIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYN 296
Query: 65 ---FHAVAFYVMDEDALSRDDVIGKVCLTRD-TIASHPKGFSGWAHLTEVDPDEEVQGEI 120
+ F V D D SR D+IG+V + +A P+ W + V D GE+
Sbjct: 297 DLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGEL 356
Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKS 175
L P A RL ++++AR+L D G SDP+V+V + + R+TS + +
Sbjct: 357 MFSLCYLP--TAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNT 414
Query: 176 CYPRWNETFEFELQEGAMEA--LCVEAWDWDLVSRNDFLG 213
P +NE F++ ++ L + D+D V N+ +G
Sbjct: 415 LNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIG 454
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/90 (32%), Positives = 52/90 (57%), Gaps = 5/90 (5%)
Query: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFELQE 190
+L + +A +L KD +GTSDP+V++ + +T + +K+ P ++E F F +
Sbjct: 236 QLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPY 295
Query: 191 GAMEA--LCVEAWDWDLVSRNDFLGKVVID 218
+EA L +D+D SR+D +G+VV+D
Sbjct: 296 NDLEARKLHFSVYDFDRFSRHDLIGQVVVD 325
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/90 (36%), Positives = 49/90 (54%), Gaps = 10/90 (11%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPI--IRTATVWKTLCPFWGEEYQVHLP 62
L I I++ +NL A DITG+SDPY V + D + +T+T TL P + E +P
Sbjct: 369 LTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVP 428
Query: 63 P----TFHAVAFYVMDEDALSRDDVIGKVC 88
P H ++ VMD D + +++IG VC
Sbjct: 429 PENIDQIH-LSIAVMDYDRVGHNEIIG-VC 456
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 81.3 bits (199), Expect = 3e-15
Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 8/119 (6%)
Query: 122 LRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR-----ETSIVKKSC 176
L+LE+ A + +V EAR+L P D NG SDP+V+++ R +T VK +
Sbjct: 161 LQLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL 219
Query: 177 YPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
P WNETF F L+ G +E L VE WDWD SRNDF+G + V L + +GW++L
Sbjct: 220 NPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277
Score = 44.3 bits (103), Expect = 5e-04
Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 8/114 (7%)
Query: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEP----IIRTATVWKTLCPFWGEEYQVHLP 62
+++ + E +NL D G SDPY +K+ +P +T TV TL P W E + +L
Sbjct: 173 IHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLK 232
Query: 63 P--TFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE 114
P ++ V D D SR+D +G + + P GW L + E
Sbjct: 233 PGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAP--VDGWYKLLNQEEGE 284
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,430,663
Number of Sequences: 37866
Number of extensions: 1431114
Number of successful extensions: 4265
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 3586
Number of HSP's gapped (non-prelim): 479
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.