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Search of human proteins with 120659787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|120659787 protein kinase D2 isoform B [Homo sapiens]
(721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 1467 0.0
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 1467 0.0
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 1467 0.0
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 1467 0.0
gi|115529463 protein kinase D1 [Homo sapiens] 1011 0.0
gi|5031689 protein kinase D3 [Homo sapiens] 961 0.0
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 186 7e-47
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 186 7e-47
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 180 4e-45
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 179 8e-45
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 179 8e-45
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 172 1e-42
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 172 1e-42
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 172 1e-42
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 171 2e-42
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 166 7e-41
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 162 1e-39
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 162 1e-39
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 159 9e-39
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 159 9e-39
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 159 9e-39
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 159 9e-39
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 159 9e-39
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 159 9e-39
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 159 1e-38
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 157 3e-38
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 156 6e-38
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 156 6e-38
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 156 6e-38
gi|27901803 protein serine kinase H1 [Homo sapiens] 156 7e-38
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 1467 bits (3797), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC
Sbjct: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
Query: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV
Sbjct: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
Query: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK
Sbjct: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
Query: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST
Sbjct: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
Query: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL
Sbjct: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
Query: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP
Sbjct: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
Query: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV
Sbjct: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
Query: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM
Sbjct: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
Query: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG
Sbjct: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
Query: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI
Sbjct: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
Query: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR
Sbjct: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
Query: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV
Sbjct: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
Query: 721 L 721
L
Sbjct: 721 L 721
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1467 bits (3797), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC
Sbjct: 158 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 217
Query: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV
Sbjct: 218 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 277
Query: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK
Sbjct: 278 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 337
Query: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST
Sbjct: 338 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 397
Query: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL
Sbjct: 398 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 457
Query: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP
Sbjct: 458 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 517
Query: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV
Sbjct: 518 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 577
Query: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM
Sbjct: 578 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 637
Query: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG
Sbjct: 638 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 697
Query: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI
Sbjct: 698 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 757
Query: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR
Sbjct: 758 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 817
Query: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV
Sbjct: 818 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 877
Query: 721 L 721
L
Sbjct: 878 L 878
Score = 67.8 bits (164), Expect = 3e-11
Identities = 27/53 (50%), Positives = 33/53 (62%)
Query: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
PH +HSY P C C ++L GL RQGL+C C N HKRCA +PN+C G
Sbjct: 138 PHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG 190
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1467 bits (3797), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC
Sbjct: 158 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 217
Query: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV
Sbjct: 218 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 277
Query: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK
Sbjct: 278 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 337
Query: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST
Sbjct: 338 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 397
Query: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL
Sbjct: 398 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 457
Query: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP
Sbjct: 458 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 517
Query: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV
Sbjct: 518 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 577
Query: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM
Sbjct: 578 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 637
Query: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG
Sbjct: 638 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 697
Query: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI
Sbjct: 698 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 757
Query: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR
Sbjct: 758 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 817
Query: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV
Sbjct: 818 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 877
Query: 721 L 721
L
Sbjct: 878 L 878
Score = 67.8 bits (164), Expect = 3e-11
Identities = 27/53 (50%), Positives = 33/53 (62%)
Query: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
PH +HSY P C C ++L GL RQGL+C C N HKRCA +PN+C G
Sbjct: 138 PHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG 190
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1467 bits (3797), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC
Sbjct: 158 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 217
Query: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV
Sbjct: 218 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 277
Query: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK
Sbjct: 278 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 337
Query: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST
Sbjct: 338 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 397
Query: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL
Sbjct: 398 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 457
Query: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP
Sbjct: 458 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 517
Query: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV
Sbjct: 518 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 577
Query: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM
Sbjct: 578 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 637
Query: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG
Sbjct: 638 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 697
Query: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI
Sbjct: 698 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 757
Query: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR
Sbjct: 758 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 817
Query: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV
Sbjct: 818 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 877
Query: 721 L 721
L
Sbjct: 878 L 878
Score = 67.8 bits (164), Expect = 3e-11
Identities = 27/53 (50%), Positives = 33/53 (62%)
Query: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
PH +HSY P C C ++L GL RQGL+C C N HKRCA +PN+C G
Sbjct: 138 PHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG 190
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 1011 bits (2613), Expect = 0.0
Identities = 519/758 (68%), Positives = 595/758 (78%), Gaps = 48/758 (6%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
ML+GLVRQGLKC+GCGLNYHKRCAF IPNNCSG R+RRLS+ SL ++R ++E
Sbjct: 166 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTS 225
Query: 61 TAEE--LSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRP 118
+E L +S +E R S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRP
Sbjct: 226 APDEPLLQKSPSESFIGREKRSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRP 281
Query: 119 TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGD---------VPM 169
TVCQ CKKLLKGLFRQGLQCKDC+FNCHKRCA +VPN+CLGE INGD V M
Sbjct: 282 TVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVM 341
Query: 170 EEATDFSEADK-SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQ------------ 216
EE +D +++++ S LMD+ E++ V ++A A E + + G+ Q
Sbjct: 342 EEGSDDNDSERNSGLMDDMEEAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRT 395
Query: 217 ---SSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQ 273
S+ IPLMRVVQSV+HT RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQ
Sbjct: 396 ISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQ 455
Query: 274 NNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS 333
N+T +RYYKEIPLSEIL++E + +L+P G NPHCFEI TAN Y+VGE P PS
Sbjct: 456 NDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPS 514
Query: 334 --------GQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQEN 385
G GA+ AR WE AI+ ALMPVI + + G HR S+SISVSN QIQEN
Sbjct: 515 PNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQEN 574
Query: 386 VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAIL 445
VDI+TVYQIFPDEVLGSGQFG+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAIL
Sbjct: 575 VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAIL 634
Query: 446 QSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVAL 505
Q+L HPG+VNLECMFETPE+VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVAL
Sbjct: 635 QNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVAL 694
Query: 506 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 565
RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV
Sbjct: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
Query: 566 LLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAID 625
L N+GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AID
Sbjct: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAID 814
Query: 626 LINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAA 685
LINNLLQVKMRKRYSVDK+LSHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A
Sbjct: 815 LINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAG 874
Query: 686 EHPL--PGSGLPTDRDLGGACPPQDHDMQGLAERISVL 721
E L P + ++ +M+ L ER+S+L
Sbjct: 875 EQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL 912
Score = 70.1 bits (170), Expect = 7e-12
Identities = 27/53 (50%), Positives = 35/53 (66%)
Query: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
PH +HSY P C C ++L GL RQGL+C+ C N HKRCA ++PN+C G
Sbjct: 146 PHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSG 198
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 961 bits (2483), Expect = 0.0
Identities = 482/707 (68%), Positives = 559/707 (79%), Gaps = 27/707 (3%)
Query: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
ML+GLVRQGLKC+GCGLNYHKRCAF IPNNCSG RKRRLS+ SL G S P
Sbjct: 174 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGP-----GLSVPRPL 228
Query: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
E ++ + E + PS S++GRPI ++KM++ +VKVPHTF +HSYTRPT+
Sbjct: 229 QPEYVALPSEESHVHQEPSKR----IPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTI 284
Query: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALING---------DVPMEE 171
CQ CK+LLKGLFRQG+QCKDCKFNCHKRCA++VP DCLGE NG D+PM+
Sbjct: 285 CQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDI 344
Query: 172 ATDFSEADKSALMDESEDSGVIPGSH---SENALHASEEEEGEGGKAQSSLGYIPLMRVV 228
+ +D S +D++E+ + L +EE + S+ IPLMRVV
Sbjct: 345 DNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVV 404
Query: 229 QSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSE 288
QS++HT RKSST ++EGW+VHY+++D LRKRHYWRLD KC+TLFQN + ++YYKEIPLSE
Sbjct: 405 QSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSE 464
Query: 289 ILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGP----SGQGAEAARGWE 344
IL + S ++F+ + G+NPHCFEI+T YFVGE G + P +G G + A+ WE
Sbjct: 465 ILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWE 524
Query: 345 TAIRQALMPVILQDAP-SAPGHAP-HRQASLSISVSNSQIQENVDIATVYQIFPDEVLGS 402
AIRQALMPV Q + ++PG H+ S SISVSN QIQENVDI+TVYQIF DEVLGS
Sbjct: 525 KAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGS 584
Query: 403 GQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFET 462
GQFG+VYGGKHRKTGRDVA+KVIDK+RFPTKQESQLRNEVAILQ+L HPGIVNLECMFET
Sbjct: 585 GQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFET 644
Query: 463 PEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPEN 522
PE+VFVVMEKLHGDMLEMILSSEK RLPER+TKF++TQILVALR+LHFKNIVHCDLKPEN
Sbjct: 645 PERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPEN 704
Query: 523 VLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGV 582
VLLASA+PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGV
Sbjct: 705 VLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGV 764
Query: 583 IMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVD 642
I+YVSLSGTFPFNEDEDINDQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVD
Sbjct: 765 IIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVD 824
Query: 643 KSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL 689
KSLSHPWLQ+YQTWLDLRE E ++GERYITHESDDARWE A H L
Sbjct: 825 KSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNL 871
Score = 73.6 bits (179), Expect = 6e-13
Identities = 29/53 (54%), Positives = 37/53 (69%)
Query: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
PHT +HSY PT C C ++L GL RQGL+C+ C N HKRCA ++PN+C G
Sbjct: 154 PHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSG 206
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 186 bits (472), Expect = 7e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 368 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 417
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 227 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 286
Query: 418 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 471
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 287 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 345
Query: 472 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 530
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 346 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 403
Query: 531 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 587
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 404 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 463
Query: 588 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 644
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 464 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 523
Query: 645 LSHPWLQE 652
L HPWLQ+
Sbjct: 524 LRHPWLQD 531
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 186 bits (472), Expect = 7e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 368 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 417
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
Query: 418 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 471
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
Query: 472 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 530
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
Query: 531 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 587
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
Query: 588 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 644
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
Query: 645 LSHPWLQE 652
L HPWLQ+
Sbjct: 481 LRHPWLQD 488
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 180 bits (457), Expect = 4e-45
Identities = 104/259 (40%), Positives = 154/259 (59%), Gaps = 11/259 (4%)
Query: 399 VLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLEC 458
V+G G F VV +HR+T + A+K+IDK R K E + +E+ I+QSL HP IV L
Sbjct: 361 VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGK-EDMVDSEILIIQSLSHPNIVKLHE 419
Query: 459 MFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCD 517
++ET ++++++E + G D+ + I+ S K PE +I + AL H+H K+IVH D
Sbjct: 420 VYETDMEIYLILEYVQGGDLFDAIIESVK--FPEPDAALMIMDLCKALVHMHDKSIVHRD 477
Query: 518 LKPENVLLA-SADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLD 576
LKPEN+L+ + D +KL DFG A+ + F +V GTP Y+APE+L +GY +D
Sbjct: 478 LKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEILSEKGYGLEVD 535
Query: 577 MWSVGVIMYVSLSGTFPFNEDEDINDQ----IQNAAFMYPASPWSHISAGAIDLINNLLQ 632
MW+ GVI+Y+ L G PF E D+ IQ F + W +IS A DL++ LL
Sbjct: 536 MWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLV 595
Query: 633 VKMRKRYSVDKSLSHPWLQ 651
V +KRY+ + L HPW++
Sbjct: 596 VDPKKRYTAHQVLQHPWIE 614
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 179 bits (454), Expect = 8e-45
Identities = 101/276 (36%), Positives = 164/276 (59%), Gaps = 8/276 (2%)
Query: 378 SNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ 437
S+S ++ DI +++ E LG+G F V + + TG+ AVK I K K ES
Sbjct: 9 SSSWKKQAEDIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESS 65
Query: 438 LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKF 496
+ NE+A+L+ ++H IV LE ++E+P +++VM+ + G ++ + I+ EKG E+
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDAST 123
Query: 497 LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG 556
LI Q+L A+ +LH IVH DLKPEN+L S D ++ + DFG +++ G+ + G
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 183
Query: 557 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPAS 614
TP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + +
Sbjct: 184 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 243
Query: 615 PWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 650
W IS A D I NL++ KRY+ +++ HPW+
Sbjct: 244 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 179 bits (454), Expect = 8e-45
Identities = 101/276 (36%), Positives = 164/276 (59%), Gaps = 8/276 (2%)
Query: 378 SNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ 437
S+S ++ DI +++ E LG+G F V + + TG+ AVK I K K ES
Sbjct: 9 SSSWKKQAEDIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESS 65
Query: 438 LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKF 496
+ NE+A+L+ ++H IV LE ++E+P +++VM+ + G ++ + I+ EKG E+
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDAST 123
Query: 497 LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG 556
LI Q+L A+ +LH IVH DLKPEN+L S D ++ + DFG +++ G+ + G
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 183
Query: 557 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPAS 614
TP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + +
Sbjct: 184 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 243
Query: 615 PWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 650
W IS A D I NL++ KRY+ +++ HPW+
Sbjct: 244 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 172 bits (435), Expect = 1e-42
Identities = 106/282 (37%), Positives = 163/282 (57%), Gaps = 13/282 (4%)
Query: 377 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 436
V+ ++ E+ + Y+I +V+G G F VV R TG++ A+K+IDK + K E
Sbjct: 378 VNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EH 434
Query: 437 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 495
+ NEV+IL+ ++HP I+ L ET ++F+VME + G D+ + I SS K ER
Sbjct: 435 LIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGS 492
Query: 496 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 554
++ + ALR+LH +IVH D+KPEN+L+ D +KL DFG A ++ + +V
Sbjct: 493 AMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TV 550
Query: 555 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 610
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF N ED+ DQI
Sbjct: 551 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLE 610
Query: 611 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
+PA W +I+ A +LI+ +LQV + R + + LSHPW+ +
Sbjct: 611 FPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 652
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 172 bits (435), Expect = 1e-42
Identities = 106/282 (37%), Positives = 163/282 (57%), Gaps = 13/282 (4%)
Query: 377 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 436
V+ ++ E+ + Y+I +V+G G F VV R TG++ A+K+IDK + K E
Sbjct: 379 VNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EH 435
Query: 437 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 495
+ NEV+IL+ ++HP I+ L ET ++F+VME + G D+ + I SS K ER
Sbjct: 436 LIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGS 493
Query: 496 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 554
++ + ALR+LH +IVH D+KPEN+L+ D +KL DFG A ++ + +V
Sbjct: 494 AMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TV 551
Query: 555 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 610
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF N ED+ DQI
Sbjct: 552 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLE 611
Query: 611 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
+PA W +I+ A +LI+ +LQV + R + + LSHPW+ +
Sbjct: 612 FPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 653
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 172 bits (435), Expect = 1e-42
Identities = 95/256 (37%), Positives = 157/256 (61%), Gaps = 8/256 (3%)
Query: 398 EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLE 457
EVLGSG F V+ K R TG+ A+K I K P ++S L NE+A+L+ ++H IV LE
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKS--PAFRDSSLENEIAVLKKIKHENIVTLE 84
Query: 458 CMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 516
++E+ ++VM+ + G ++ + IL E+G E+ +I Q+L A+++LH IVH
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRIL--ERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142
Query: 517 DLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLD 576
DLKPEN+L + + ++ + DFG +++ + + GTP Y+APEVL + Y++++D
Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKPYSKAVD 201
Query: 577 MWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLINNLLQVK 634
WS+GVI Y+ L G PF E+ + + ++I+ + + + W IS A D I +LL+
Sbjct: 202 CWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD 261
Query: 635 MRKRYSVDKSLSHPWL 650
+RY+ +K+LSHPW+
Sbjct: 262 PNERYTCEKALSHPWI 277
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 171 bits (433), Expect = 2e-42
Identities = 97/278 (34%), Positives = 164/278 (58%), Gaps = 8/278 (2%)
Query: 376 SVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQE 435
+V + ++ DI +Y +VLG+G F V + ++T + VA+K I K K E
Sbjct: 4 AVEGPRWKQAEDIRDIYDF--RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGK-E 60
Query: 436 SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLT 494
+ NE+A+L ++HP IV L+ ++E+ ++++M+ + G ++ + I+ EKG ER
Sbjct: 61 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIV--EKGFYTERDA 118
Query: 495 KFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSV 554
LI Q+L A+++LH IVH DLKPEN+L S D ++ + DFG +++ S +
Sbjct: 119 SRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTA 178
Query: 555 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYP 612
GTP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + +
Sbjct: 179 CGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFD 238
Query: 613 ASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 650
+ W IS A D I +L++ KR++ +++L HPW+
Sbjct: 239 SPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 166 bits (420), Expect = 7e-41
Identities = 93/255 (36%), Positives = 147/255 (57%), Gaps = 10/255 (3%)
Query: 400 LGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECM 459
LG G +VY K + T + A+KV+ K T + +R E+ +L L HP I+ L+ +
Sbjct: 52 LGRGATSIVYRCKQKGTQKPYALKVLKK----TVDKKIVRTEIGVLLRLSHPNIIKLKEI 107
Query: 460 FETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDL 518
FETP ++ +V+E + G ++ + I+ EKG ER + QIL A+ +LH IVH DL
Sbjct: 108 FETPTEISLVLELVTGGELFDRIV--EKGYYSERDAADAVKQILEAVAYLHENGIVHRDL 165
Query: 519 KPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMW 578
KPEN+L A+ P +K+ DFG ++I+ + ++V GTP Y APE+L Y +DMW
Sbjct: 166 KPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMW 225
Query: 579 SVGVIMYVSLSGTFPFNE---DEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKM 635
SVG+I Y+ L G PF + D+ + +I N + + + W +S A DL+ L+ +
Sbjct: 226 SVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDP 285
Query: 636 RKRYSVDKSLSHPWL 650
+KR + ++L HPW+
Sbjct: 286 KKRLTTFQALQHPWV 300
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 162 bits (409), Expect = 1e-39
Identities = 114/348 (32%), Positives = 184/348 (52%), Gaps = 27/348 (7%)
Query: 325 PGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQE 384
PG P GP Q EAAR G P R ++++ +
Sbjct: 47 PGAGPAGP--QLREAARA--------------SSGLGGGGRHPSRIPAIALQDMLLLKKH 90
Query: 385 NVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAI 444
DI++VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+
Sbjct: 91 TEDISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAV 147
Query: 445 LQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILV 503
L+ + HP IV LE + E+P +++ ME + G ++ + I+ E+G E+ L+ Q+L
Sbjct: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLG 205
Query: 504 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 563
A+ +LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+AP
Sbjct: 206 AVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAP 264
Query: 564 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISA 621
E+L + Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + + W IS
Sbjct: 265 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324
Query: 622 GAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGER 669
A D I +LL+ +KR++ ++L H W+ T D R++ G + E+
Sbjct: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWISG-DTAFD-RDILGSVSEQ 370
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 162 bits (409), Expect = 1e-39
Identities = 100/331 (30%), Positives = 164/331 (49%), Gaps = 22/331 (6%)
Query: 326 GGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQEN 385
G +PG SG G A RG R P P A + V Q+
Sbjct: 11 GSSPGATSGSG-RAGRGLSGPCR-----------PPPPPQARGLLTEIRAVVRTEPFQDG 58
Query: 386 VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAIL 445
Y + P LG G+F VV + +G++ A K + K R ++ +E+A+L
Sbjct: 59 ------YSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVL 112
Query: 446 QSLR-HPGIVNLECMFETPEKVFVVME-KLHGDMLEMILSSEKGRLPERLTKFLITQILV 503
+ + +P ++NL ++ET ++ +V+E G++ + ++ + E+ + L+ QIL
Sbjct: 113 ELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILE 172
Query: 504 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 563
+ LH +++VH DLKP+N+LL S P +K+ DFG +RI+ R ++GTP Y+AP
Sbjct: 173 GVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAP 232
Query: 564 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISA 621
E+L + + DMWS+GV+ YV L+G PF N+ ++ I Y + +S
Sbjct: 233 EILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSE 292
Query: 622 GAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
A+D I LL K R + ++ L HPWL +
Sbjct: 293 SAVDFIRTLLVKKPEDRATAEECLKHPWLTQ 323
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 159 bits (402), Expect = 9e-39
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 392 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 451
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 452 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 510
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 511 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 569
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 570 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 627
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 628 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 655
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 159 bits (401), Expect = 1e-38
Identities = 101/286 (35%), Positives = 166/286 (58%), Gaps = 11/286 (3%)
Query: 387 DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ 446
DI++VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+L+
Sbjct: 27 DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLR 83
Query: 447 SLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVAL 505
+ HP IV LE + E+P +++ ME + G ++ + I+ E+G E+ L+ Q+L A+
Sbjct: 84 RISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAV 141
Query: 506 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 565
+LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+APE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPEL 200
Query: 566 LLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGA 623
L + Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + + W IS A
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
Query: 624 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGER 669
D I +LL+ +KR++ ++L H W+ T D R++ G + E+
Sbjct: 261 KDFIRHLLERDPQKRFTCQQALRHLWISG-DTAFD-RDILGSVSEQ 304
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 157 bits (397), Expect = 3e-38
Identities = 99/282 (35%), Positives = 156/282 (55%), Gaps = 13/282 (4%)
Query: 377 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 436
VS Q I Y++ +G G F VV R T R+ A+K+I K + K E
Sbjct: 375 VSEEGFQIPATITERYKV--GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGK-EH 431
Query: 437 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 495
++NEV+IL+ ++HP IV L + P ++++VME + G D+ + I S+ K ER
Sbjct: 432 MIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNK--YTERDAS 489
Query: 496 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 554
++ + A+++LH NIVH D+KPEN+L+ D +KL DFG A I+ + +V
Sbjct: 490 GMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY--TV 547
Query: 555 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 610
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF ++ E + DQI
Sbjct: 548 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD 607
Query: 611 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
+P+ W ++S A +LI +L V + +R+S + L HPW+ +
Sbjct: 608 FPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 649
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 156 bits (395), Expect = 6e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 384 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 440
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 441 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 497
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 498 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 556
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 557 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 615
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 616 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 156 bits (395), Expect = 6e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 384 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 440
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 441 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 497
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 498 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 556
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 557 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 615
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 616 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 156 bits (395), Expect = 6e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 384 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 440
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 441 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 497
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 498 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 556
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 557 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 615
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 616 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 652
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 156 bits (394), Expect = 7e-38
Identities = 100/322 (31%), Positives = 164/322 (50%), Gaps = 12/322 (3%)
Query: 360 PSAPGHA-PHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGR 418
P GH P + V+ + + + + Y I ++G G F V +HR T +
Sbjct: 65 PPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDI--KALIGRGSFSRVVRVEHRATRQ 122
Query: 419 DVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVME-KLHGDM 477
A+K+I+ ++ + +E+ +L+ +RH I+ L +FET E+V++VME G++
Sbjct: 123 PYAIKMIETKYREGREVCE--SELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL 180
Query: 478 LEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLC 537
+ I++ KG ER ++ +L +R+LH I H DLKPEN+L ++ +
Sbjct: 181 FDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIIT 238
Query: 538 DFGFA--RIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFN 595
DFG A R G+ ++ GTP Y+APEVL+ + Y S+DMW++GVI Y+ LSGT PF
Sbjct: 239 DFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFE 298
Query: 596 EDE--DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEY 653
+D + QI + Y PW +S A D I+ LL V R + ++L HPW+
Sbjct: 299 DDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSM 358
Query: 654 QTWLDLRELEGKMGERYITHES 675
++ L + + + S
Sbjct: 359 AASSSMKNLHRSISQNLLKRAS 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,467,767
Number of Sequences: 37866
Number of extensions: 1414232
Number of successful extensions: 9123
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 636
Number of HSP's successfully gapped in prelim test: 242
Number of HSP's that attempted gapping in prelim test: 6246
Number of HSP's gapped (non-prelim): 1347
length of query: 721
length of database: 18,247,518
effective HSP length: 110
effective length of query: 611
effective length of database: 14,082,258
effective search space: 8604259638
effective search space used: 8604259638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.