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Search of human proteins with 12056468
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12056468 junction plakoglobin [Homo sapiens]
(745 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504811 junction plakoglobin [Homo sapiens] 1469 0.0
gi|12056468 junction plakoglobin [Homo sapiens] 1469 0.0
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 952 0.0
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 952 0.0
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 952 0.0
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 77 8e-14
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 76 1e-13
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 57 6e-08
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 53 1e-06
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 52 2e-06
gi|4504897 karyopherin alpha 2 [Homo sapiens] 51 3e-06
gi|4502247 armadillo repeat protein [Homo sapiens] 51 4e-06
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 46 1e-04
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 46 1e-04
gi|53729344 plakophilin 1 isoform 1a [Homo sapiens] 46 1e-04
gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo ... 46 1e-04
gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04
gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04
gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 45 2e-04
gi|189011568 adenomatous polyposis coli [Homo sapiens] 44 4e-04
gi|189011566 adenomatous polyposis coli [Homo sapiens] 44 4e-04
gi|53759122 adenomatous polyposis coli [Homo sapiens] 44 4e-04
gi|224589129 karyopherin 7 [Homo sapiens] 44 5e-04
gi|6005830 plakophilin 3 [Homo sapiens] 42 0.002
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 41 0.005
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 39 0.013
gi|6912478 karyopherin alpha 6 [Homo sapiens] 38 0.030
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 38 0.039
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 38 0.039
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 1469 bits (3804), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT
Sbjct: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
Query: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS
Sbjct: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE
Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH
Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC
Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY
Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR
Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY
Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM
Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
DGDYPIDTYSDGLRPPYPTADHMLA
Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 1469 bits (3804), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT
Sbjct: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
Query: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS
Sbjct: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE
Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH
Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC
Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY
Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR
Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY
Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM
Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
DGDYPIDTYSDGLRPPYPTADHMLA
Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 952 bits (2462), Expect = 0.0
Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)
Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q +
Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67
Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA
Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126
Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186
Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246
Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306
Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366
Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426
Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486
Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546
Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606
Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
+ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666
Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726
Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
D L M M+ DYP+D D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 952 bits (2462), Expect = 0.0
Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)
Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q +
Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67
Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA
Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126
Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186
Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246
Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306
Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366
Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426
Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486
Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546
Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606
Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
+ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666
Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726
Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
D L M M+ DYP+D D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 952 bits (2462), Expect = 0.0
Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)
Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q +
Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67
Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA
Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126
Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186
Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246
Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306
Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366
Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426
Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486
Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546
Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606
Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
+ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666
Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726
Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
D L M M+ DYP+D D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 76.6 bits (187), Expect = 8e-14
Identities = 111/528 (21%), Positives = 208/528 (39%), Gaps = 52/528 (9%)
Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTS--- 197
LP + +L+ + AA + ++K + +RR + G +LVA + +T
Sbjct: 537 LPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQ 596
Query: 198 -------DLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTL 250
D++ ARC L + S AI K+GGIP L R+L + E++L + TL
Sbjct: 597 SSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTL 656
Query: 251 HNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANG 310
+E + A++ ++ +V LN N + + A ++E++ ++ +G
Sbjct: 657 QE-CASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCA-EDKETRDLVRLHG 714
Query: 311 GPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQ 370
G + L ++ N ++ L + + S+ N E ++ L LT ++
Sbjct: 715 GLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLV 774
Query: 371 NCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSK 424
N + L R + K G++ ++ +LV VNV T A G C
Sbjct: 775 NVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNV-TKAVG-----ACAVEP 828
Query: 425 NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPA 484
++ L+ ++L+ D A + + EM ++ V G+
Sbjct: 829 ESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVG---GLEL 885
Query: 485 IVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAA 544
IV LL N+ ++ + I N+A N A + + V+P L +L + + H+A
Sbjct: 886 IVNLLKSDNK-EVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLA- 943
Query: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
E I C NR+ + V+ L S+ N+ R
Sbjct: 944 ------------EAISRCCMWG--------RNRVAFGEHKAVAPLVRYLKSNDTNVHRAT 983
Query: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRI 652
A L +L++D + + GA L++++ S ++ AA + I
Sbjct: 984 AQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNI 1031
Score = 65.5 bits (158), Expect = 2e-10
Identities = 113/507 (22%), Positives = 198/507 (39%), Gaps = 60/507 (11%)
Query: 195 NTSDLDTARC---TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLH 251
N + D +C + IL +SH+ + I GG+P +V +L SP +S+ A T+
Sbjct: 501 NLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIA 560
Query: 252 NLLLYQEGAKMAVRLADGLQKMVPLL----NKNNPKFLAI-------TTDCLQLLAYGNQ 300
N+ ++ A+ VR G+ K+V LL + P ++ C L +
Sbjct: 561 NVAKFKR-ARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCS 619
Query: 301 ES---KLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
+S K I GG L ++++ S+E +L L+ + + + AI ++ L
Sbjct: 620 KSHTNKEAIRKAGGIPLLARLLKT-SHENMLIPVVGTLQECASEENYRAAIKAERIIENL 678
Query: 358 GKHLTSNSPRLVQNCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCA 411
K+L S + +L ++C + + D+ GL+ + +L N D+ L
Sbjct: 679 VKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNN---TDNKERLAAV 735
Query: 412 TGTLSNLTCNNSK-NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAE 470
TG + C+ SK N T + +E L+ L +++ V AL
Sbjct: 736 TGAI--WKCSISKENVTKFREYKAIETLVG--LLTDQPEEVLVNVVGALGECCQERENRV 791
Query: 471 MAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQL 530
+ VR GI +V LL NQ LV T + A+ P + + + L L
Sbjct: 792 I----VRKCGGIQPLVNLLVGINQALLVNVT-KAVGACAVEPESMMIIDRLDGVRLLWSL 846
Query: 531 LVKAHQDAQRHVA------------AGTQ-QPYTDGVRM---------EEIVEGCTGALH 568
L H D + A AG + + G+ + +E++ A+
Sbjct: 847 LKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAIT 906
Query: 569 ILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASA 628
+A+D N I +PL +L ++ ++ A + A A A
Sbjct: 907 NIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVA 966
Query: 629 PLMELLHSRNEGTATYAAAVLFRISED 655
PL+ L S + A L+++SED
Sbjct: 967 PLVRYLKSNDTNVHRATAQALYQLSED 993
Score = 57.8 bits (138), Expect = 4e-08
Identities = 95/470 (20%), Positives = 193/470 (41%), Gaps = 52/470 (11%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
I LV+ L ++ A+ ++ + L QE ++A+R GL+ ++ LL + K
Sbjct: 454 IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIG 513
Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
+ L+ +++ N + + I+ GG +V I+ + ++ L + + ++ +
Sbjct: 514 SLKILKEISH-NPQIRQNIVDLGGLPIMVNIL-DSPHKSLKCLAAETIANVAKFKRARRV 571
Query: 348 IVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNL-------------SDVATKQEGLESV 392
+ + GG+ L L +S + Q+ L+ R++ S T +E +
Sbjct: 572 VRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKA 631
Query: 393 --LKILVNQLSVDDVNVLTCATGTLSNLTCNNSKN-KTLVTQNSGVEALIHAILRAGDKD 449
+ +L L N+L GTL C + +N + + +E L+ + + +
Sbjct: 632 GGIPLLARLLKTSHENMLIPVVGTLQE--CASEENYRAAIKAERIIENLVKNL--NSENE 687
Query: 450 DITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLA 509
+ E A+ E + ++ VRL+ G+ + LLN + + A G I +
Sbjct: 688 QLQEHCAMAIYQCA----EDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCS 743
Query: 510 LCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA------------------AGTQQPYT 551
+ N +E I LV LL ++ +V G QP
Sbjct: 744 ISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLV 803
Query: 552 D---GVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVL 608
+ G+ + ++ T A+ A +P + M I RL+ + L LL + +++ AA L
Sbjct: 804 NLLVGIN-QALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWAL 862
Query: 609 CELAQD-KEAADAIDA-EGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
C ++ K+A + + + G ++ LL S N+ A + I++D+
Sbjct: 863 CPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQ 912
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 75.9 bits (185), Expect = 1e-13
Identities = 105/480 (21%), Positives = 205/480 (42%), Gaps = 48/480 (10%)
Query: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTA 202
A+ LTKLL ED +V A MI L+ ++ L+ ++ +V+ + ++
Sbjct: 68 AVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK-LLRELDVMNSVIAQLAPEEEVVIH 126
Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLL-YQEGAK 261
+ L N+S + IF+ GG+ L+R+LSSP V ++ ++NL+ +Q AK
Sbjct: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAK 186
Query: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRN 321
+ + + + ++ LL P + L ++A ++ES+ ++ N G L++I+
Sbjct: 187 L--QELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILET 243
Query: 322 YSYEKLLWTTSRVLKVLSVCPSNKPAIV---EAGGMQALGKHL-TSNSPRLVQNCLWTLR 377
L L V++ C + +V + GG++ L S P + +N +
Sbjct: 244 KELNDL---HIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKN---AAK 297
Query: 378 NLSDVATKQEGL-----ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQN 432
++ A E + V K LV L ++ A+ +S + C NS +K N
Sbjct: 298 AITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAM-CENSGSKDFF-NN 355
Query: 433 SGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQP 492
G+ LI L D +++ E A AL +LT+ +P N+ GI ++ LL+
Sbjct: 356 QGIPQLIQ--LLKSDNEEVREAAALALANLTTCNP---ANANAAAEADGIDPLINLLSSK 410
Query: 493 NQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA--------- 543
+ A ++ N+A+ +Q ++ ++ L A+ Q A
Sbjct: 411 RDGAIANAAT-VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD 469
Query: 544 ---------AGTQQPYTDGVRM--EEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQL 592
+G +P + +R +E+ + + A+ + A D + E+ RL + + ++
Sbjct: 470 VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEV 529
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 42/373 (11%)
Query: 314 ALVQIMRNYSYEKLLWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNC 372
A V +M N E++L + K NK ++E G ++ L K LT + +N
Sbjct: 28 ATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNA 87
Query: 373 LWT---LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLV 429
L + +DV L+ + ++ ++V + A+ L+N++ + +K +
Sbjct: 88 TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT-SKVQI 146
Query: 430 TQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
++ G+E LI +L + D D C + A++ + LN IP I+ LL
Sbjct: 147 FEHGGLEPLIR-LLSSPDPDVKKNSMECIYNLVQDFQCRAKLQE----LN-AIPPILDLL 200
Query: 490 NQPNQWPLVKA----TIGLIRNLALCPANHAPLQEAAVIPRLVQLL-VKAHQDAQRHVAA 544
+++P+++ T+G+I N + L++ + L+++L K D A
Sbjct: 201 K--SEYPVIQLLALKTLGVIAN---DKESRTMLRDNQGLDHLIKILETKELNDLHIEALA 255
Query: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
D M +I + TG L L N S++ +IQ+ A
Sbjct: 256 VIANCLEDMDTMVQIQQ--TGGLKKLLSFAEN------------------STIPDIQKNA 295
Query: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK-NPDYRKR 663
A + + A D E + L+ LL S N+GT A+ + + E+ + D+
Sbjct: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNN 355
Query: 664 VSVELTNSLFKHD 676
+ L K D
Sbjct: 356 QGIPQLIQLLKSD 368
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 57.0 bits (136), Expect = 6e-08
Identities = 76/336 (22%), Positives = 148/336 (44%), Gaps = 23/336 (6%)
Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
+CT +L S + + +F G A R +++ ++ T H +L + K+
Sbjct: 568 QCTPLLLAATSGALDTIQYLFSIG---ANWRKTDIKGNNIIHLSVLTFHTEVL-KYIIKL 623
Query: 263 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 322
+ + +V +L + K + L+++ N + IL G AL+ ++++
Sbjct: 624 NIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS- 682
Query: 323 SYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-- 380
S KL T +L +S S A+VEAGG+ +L L + P + C L +++
Sbjct: 683 SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742
Query: 381 ---DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEA 437
DV K G+ S L+N L+++ NVL + L N N+ V ++ G+
Sbjct: 743 ENKDVIAKYNGIPS----LINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY 798
Query: 438 LIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPL 497
LI + + D D + + A+ + + E Q+++ + IP +V L
Sbjct: 799 LIRFL--SSDSDVLKAVSSAAIAEVGRDNKE---IQDAIAMEGAIPPLVALFKGKQISVQ 853
Query: 498 VKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVK 533
+K + + +LA +++A +Q+A + L + L+K
Sbjct: 854 MKGAMA-VESLA---SHNALIQKAFLEKSLTKYLLK 885
Score = 54.3 bits (129), Expect = 4e-07
Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 16/291 (5%)
Query: 205 TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAV 264
T +L N+S H+ + A+ ++GGIP+L+ +L V L+++ + K +
Sbjct: 691 TVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCEN--KDVI 748
Query: 265 RLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
+G+ ++ LLN N L +C+++L GN+ ++ + + G L++ + + S
Sbjct: 749 AKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSD 808
Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL-----GKHLTSNSPRLVQNCLWTLRNL 379
+++ + +V + AI G + L GK ++ + + +L +
Sbjct: 809 VLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM--AVESLASH 866
Query: 380 SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
+ + K +S+ K L+ L ++V L L K + + + G +I
Sbjct: 867 NALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFII 926
Query: 440 HAILRAGDK-DDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
+ +L K + AV AL ++ M QN + GI +V+LL
Sbjct: 927 NMLLSPSAKMQYVGGEAVIAL------SKDSRMHQNQICEGNGIAPLVRLL 971
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 9/180 (5%)
Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTSDLD 200
+P L LL + K +++ +S +++ AL+ G P L+ +V
Sbjct: 673 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVH--- 729
Query: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260
+RC IL++++ E I K GIP+L+ +L+ +E+VL + + L + E
Sbjct: 730 -SRCAV-ILYDIAQC-ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
+ AVR GL ++ L+ ++ A+++ + + N+E + I G LV + +
Sbjct: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFK 846
Score = 42.0 bits (97), Expect = 0.002
Identities = 43/177 (24%), Positives = 74/177 (41%), Gaps = 22/177 (12%)
Query: 482 IPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH 541
IPA++ LL ++ L T+GL+ N++ + L EA IP L+ LLV +
Sbjct: 673 IPALINLLKS-SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSR 731
Query: 542 VAAG----TQQPYTD---------------GVRMEEIVEGCTGALHILARDPMNRMEIFR 582
A Q D + +E ++ + +L N R
Sbjct: 732 CAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVR 791
Query: 583 LNT-IPLFVQLLYSSVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
+ +P ++ L S + ++ V++ + E+ +D KE DAI EGA PL+ L +
Sbjct: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGK 848
Score = 35.8 bits (81), Expect = 0.15
Identities = 23/80 (28%), Positives = 36/80 (45%)
Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNE 639
I TIP + LL SS +Q G+L ++ K A A+ G L+ LL
Sbjct: 667 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEP 726
Query: 640 GTATYAAAVLFRISEDKNPD 659
+ A +L+ I++ +N D
Sbjct: 727 EVHSRCAVILYDIAQCENKD 746
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 52.8 bits (125), Expect = 1e-06
Identities = 45/207 (21%), Positives = 92/207 (44%), Gaps = 5/207 (2%)
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
K + + + ++V L++++ K CL L+ Q+ + + + L+++++
Sbjct: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422
Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
N E L+ +S + +L +K I+E+G ++ L S +P L N +W L N++
Sbjct: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482
Query: 381 DVATKQEGLESVLKILVNQ----LSVDDVNVLTCATGTLSNLTCNNSK-NKTLVTQNSGV 435
A ++ + + + Q LS D+NVL G L NL +K + T +
Sbjct: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542
Query: 436 EALIHAILRAGDKDDITEPAVCALRHL 462
+ IL ++ E +C L ++
Sbjct: 543 MQAVTLILEGEHNIEVKEQTLCILANI 569
Score = 43.1 bits (100), Expect = 0.001
Identities = 78/376 (20%), Positives = 160/376 (42%), Gaps = 36/376 (9%)
Query: 101 LLATQVEGQATNLQRLAEPS---QLLKSAIVHLINYQDDA---ELATRALPELTKLLNDE 154
LL +VEG T L L EP Q + S HLI D + A+ ++ +L +D
Sbjct: 279 LLEERVEGAET-LAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDL 337
Query: 155 DPVVVTKAA---MIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTS---DLDTARCTTSI 208
+ A + + + E R+ ++ + ++ +V + +S L RC
Sbjct: 338 KHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRC---- 393
Query: 209 LHNLSHHREGLLAIFKSGGI-PALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
LH+LS + L F+ + L+++L + + +L A + L NLLL +K + +
Sbjct: 394 LHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILES 453
Query: 268 DGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSYEK 326
++ + L NP L +A+ Q+ K IL + + L +++ +
Sbjct: 454 GAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513
Query: 327 LLWTTSRVLKVLSVCP-------SNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL 379
L+ T + +LS P ++ I++A + G+H + + + L L N+
Sbjct: 514 LMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEH----NIEVKEQTLCILANI 569
Query: 380 SDVATKQEGL---ESVLKILVNQLSVDDVNVLTCATGTLSNLTCN---NSKNKTLVTQNS 433
+D T ++ + + +L+ + + V + A +SNL N S+ + ++
Sbjct: 570 ADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDM 629
Query: 434 GVEALIHAILRAGDKD 449
G+ ++H + ++ D +
Sbjct: 630 GIVDILHKLSQSPDSN 645
>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
plakophilin-related arm-repeat protein) [Homo sapiens]
Length = 1225
Score = 52.0 bits (123), Expect = 2e-06
Identities = 61/245 (24%), Positives = 103/245 (42%), Gaps = 29/245 (11%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
+P +++ML SV A L +L K +R G+Q +V LL+ +
Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRS 611
Query: 288 TTDCLQLLAYG--NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
L+ L YG N ++K+ + GG ALV+++R + ++ + VL LS C + K
Sbjct: 612 ACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALK 671
Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
I +Q+ L L N V G E+ ++ +
Sbjct: 672 MPI--------------------IQDALAVLTNA--VIIPHSGWENSPLQDDRKIQLHSS 709
Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSGV-EALIHAILRAGDKDDI----TEPAVCALR 460
VL ATG L N++ + + + + G+ +AL++ I A +I E VC LR
Sbjct: 710 QVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILR 769
Query: 461 HLTSR 465
+L+ R
Sbjct: 770 NLSYR 774
Score = 37.0 bits (84), Expect = 0.067
Identities = 93/412 (22%), Positives = 158/412 (38%), Gaps = 87/412 (21%)
Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQL----SKKEASRRALMGSPQLVAAVVRTMQNTSDL 199
LPE+ ++L + P V + AA + L +K +A R G LV + M
Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMT----- 606
Query: 200 DTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLY 256
+ R L NL + + + +A+ GGIPALVR+L + + +T
Sbjct: 607 EVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVT-------- 658
Query: 257 QEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALV 316
G + D L+ +P++ LA+ T+ + + G + S L +
Sbjct: 659 --GVLWNLSSCDALK--MPIIQ----DALAVLTNAVIIPHSGWENSPL------QDDRKI 704
Query: 317 QIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGM---------QALGKHLTSNSPR 367
Q+ +S + L T + V S + + E G+ ALG + +
Sbjct: 705 QL---HSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGS--SEIDSK 759
Query: 368 LVQNCLWTLRNLSD--VATKQEGLESVLKILVNQLSVDDVNVLTCATGT---LSNLTCNN 422
V+NC+ LRNLS A +G + D+++ L C + C
Sbjct: 760 TVENCVCILRNLSYRLAAETSQG---------QHMGTDELDGLLCGEANGKDAESSGCWG 810
Query: 423 SKNKTLVTQN---------------SGVEALIH--------AILRAGDKDDITEPAVCAL 459
K K +Q+ G++ L H +L D E A AL
Sbjct: 811 KKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGAL 870
Query: 460 RHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLAL 510
++L + + + + +VR G+P +V+LL N +V A +RN+AL
Sbjct: 871 QNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDND-RVVCAVATALRNMAL 921
Score = 35.4 bits (80), Expect = 0.19
Identities = 33/137 (24%), Positives = 64/137 (46%), Gaps = 11/137 (8%)
Query: 389 LESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDK 448
L V+++L +Q +V + A L +L ++K K + + G++ L+ +
Sbjct: 552 LPEVIQMLQHQFP----SVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHR--M 605
Query: 449 DDITEPAVCALRHLTSRHPEAEMAQNSVRLNY--GIPAIVKLLNQPNQWPLVKATIGLIR 506
++ A ALR+L + N + L GIPA+V+LL + + + G++
Sbjct: 606 TEVHRSACGALRNLVYGKANDD---NKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLW 662
Query: 507 NLALCPANHAPLQEAAV 523
NL+ C A P+ + A+
Sbjct: 663 NLSSCDALKMPIIQDAL 679
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 51.2 bits (121), Expect = 3e-06
Identities = 94/481 (19%), Positives = 186/481 (38%), Gaps = 79/481 (16%)
Query: 95 GEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAE--LATRALPELTKLLN 152
G+DS+ + ++E L++ + Q+LK V ++ DDA L + T +
Sbjct: 21 GKDSTEMRRRRIEVNV-ELRKAKKDDQMLKRRNVS--SFPDDATSPLQENRNNQGTVNWS 77
Query: 153 DEDPVVVTKAAMIVNQLSKKEASRRALMGS--------------PQLVAAVVRTMQNTSD 198
+D V ++ + NQL +A+R+ L P+ V+ + RT +
Sbjct: 78 VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137
Query: 199 LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNL----- 253
++A T+I S + A+ G IPA + +L+SP + A+ L N+
Sbjct: 138 FESAWALTNIASGTSEQTK---AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 194
Query: 254 ----LLYQEGA----------------------------------KMAVRLADGLQKMVP 275
L+ + GA K D +++++P
Sbjct: 195 VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILP 254
Query: 276 ----LLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 331
LL+ ++P+ LA T + L G E +++ G LV+++ +
Sbjct: 255 TLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL 314
Query: 332 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 391
+ +++ +++AG + LT+ + + WT+ N++ A +Q+ ++
Sbjct: 315 RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT--AGRQDQIQQ 372
Query: 392 VLK-----ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAG 446
V+ LV+ LS D A ++N T + + + + G+ + +L A
Sbjct: 373 VVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAK 432
Query: 447 DKDDITE--PAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGL 504
D I A+ + + E E + G+ I L N N+ + KA++ L
Sbjct: 433 DTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENE-SVYKASLSL 491
Query: 505 I 505
I
Sbjct: 492 I 492
Score = 38.9 bits (89), Expect = 0.018
Identities = 44/176 (25%), Positives = 77/176 (43%), Gaps = 26/176 (14%)
Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-------DVATKQEGLESVLKILVNQ 399
A+V+ G + A L S + + +W L N++ D+ K ++ +L +
Sbjct: 157 AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL---- 212
Query: 400 LSVDDVNVLTCATGTLSNLT---CNNSKNKTLVTQNSGVEALIHAILRAGDKDD--ITEP 454
L+V D++ L C G L NLT N +NK VE ++ ++R DD +
Sbjct: 213 LAVPDMSSLAC--GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270
Query: 455 AVCALRHLTSRHPE--AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL 508
A+ +LT E + + V +P +VKLL ++ P+V + I N+
Sbjct: 271 TCWAISYLTDGPNERIGMVVKTGV-----VPQLVKLLG-ASELPIVTPALRAIGNI 320
>gi|4502247 armadillo repeat protein [Homo sapiens]
Length = 962
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 28/242 (11%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
+P ++ ML PV+ V A L +L EG K VR GL +V LL+ +
Sbjct: 360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRR 419
Query: 288 TTDCLQLLAYG-NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKP 346
L+ L+YG + ++K I GG ALV+++R ++ + L LS K
Sbjct: 420 ACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKM 479
Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVN 406
I++ G+Q L + +V + W D + +V K
Sbjct: 480 VIID-HGLQTLTHEV------IVPHSGWEREPNEDSKPRDAEWTTVFK------------ 520
Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-VEALIHAILRAGDKDDI----TEPAVCALRH 461
+G L N++ + ++ + + + G V+AL+HA+ A + D E VC +R+
Sbjct: 521 ---NTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRN 577
Query: 462 LT 463
L+
Sbjct: 578 LS 579
Score = 42.7 bits (99), Expect = 0.001
Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 21/179 (11%)
Query: 102 LATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDE-DPVVVT 160
LA G +L RL S + SA + + LPE+ +L DPV
Sbjct: 325 LAQPERGSMGSLDRLVRRSPSVDSA-------RKEPRWRDPELPEVLAMLRHPVDPVKAN 377
Query: 161 KAAMIVNQLSKKEASRRA---LMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHRE 217
AA + + + E +R L G P LVA + + + R L NLS+ R+
Sbjct: 378 AAAYLQHLCFENEGVKRRVRQLRGLPLLVALL-----DHPRAEVRRRACGALRNLSYGRD 432
Query: 218 --GLLAIFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKM 273
AI GG+PALVR+L + ++ + +T TL NL Y E KM + + GLQ +
Sbjct: 433 TDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSY-EPLKMVI-IDHGLQTL 489
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 45.8 bits (107), Expect = 1e-04
Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
+P ++ ML SV A L +L KM V G++ +V LL+ +
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
L+ L +G E+K+ + GG AL++++R ++ + VL LS C + K
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649
Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
I+ AL T + +V + W + D +++
Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687
Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460
VL TG L NL+ + + + G V++L IH + D D T E VC LR
Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747
Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501
+L+ R E+ RL G+ + LL ++P+ W K
Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803
Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553
+G I L+ P L +V+ + LL ++ A +AG+ Q + G
Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856
Score = 37.7 bits (86), Expect = 0.039
Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%)
Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185
+D E A R LPE+ +L + P V AA + L K E R L G L
Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575
Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242
V + + L+ + L NL + E +A+ GGIPAL+R+L +++
Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630
Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284
+ +T + L + KM + + D L + VP NN F
Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689
Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344
L TT CL+ L+ +E++ + MR S E L+ +L V+ C +
Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731
Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404
+ + V+NC+ TLRNLS L++ V Q +
Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764
Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440
+N L G S +C K K L GVE L H
Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824
Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492
+L E + +L++L++ + + A + +VR G+P +V+LL
Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884
Query: 493 NQWPLVKATIGLIRNLAL 510
N +V + +RN+AL
Sbjct: 885 ND-RVVSSVATALRNMAL 901
Score = 34.7 bits (78), Expect = 0.33
Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%)
Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400
+ A+ + G+ L + L ++ R+V + LRN++ DV K+ + ++ LVN+L
Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924
Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451
S + + + CA L +T N +N + + G+E L++ GD+ +
Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978
Score = 30.8 bits (68), Expect = 4.8
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%)
Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439
+ A + L V+ +L +Q N A L +L ++K K V + G++ L+
Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577
Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494
H +L ++ + A ALR+L E ++A +V GIPA+++LL +
Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628
Query: 495 WPLVKATIGLIRNLALCPA 513
+ + G++ NL+ C A
Sbjct: 629 AEVRELVTGVLWNLSSCDA 647
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 45.8 bits (107), Expect = 1e-04
Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
+P ++ ML SV A L +L KM V G++ +V LL+ +
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
L+ L +G E+K+ + GG AL++++R ++ + VL LS C + K
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649
Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
I+ AL T + +V + W + D +++
Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687
Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460
VL TG L NL+ + + + G V++L IH + D D T E VC LR
Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747
Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501
+L+ R E+ RL G+ + LL ++P+ W K
Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803
Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553
+G I L+ P L +V+ + LL ++ A +AG+ Q + G
Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856
Score = 37.7 bits (86), Expect = 0.039
Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%)
Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185
+D E A R LPE+ +L + P V AA + L K E R L G L
Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575
Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242
V + + L+ + L NL + E +A+ GGIPAL+R+L +++
Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630
Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284
+ +T + L + KM + + D L + VP NN F
Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689
Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344
L TT CL+ L+ +E++ + MR S E L+ +L V+ C +
Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731
Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404
+ + V+NC+ TLRNLS L++ V Q +
Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764
Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440
+N L G S +C K K L GVE L H
Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824
Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492
+L E + +L++L++ + + A + +VR G+P +V+LL
Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884
Query: 493 NQWPLVKATIGLIRNLAL 510
N +V + +RN+AL
Sbjct: 885 ND-RVVSSVATALRNMAL 901
Score = 34.7 bits (78), Expect = 0.33
Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%)
Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400
+ A+ + G+ L + L ++ R+V + LRN++ DV K+ + ++ LVN+L
Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924
Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451
S + + + CA L +T N +N + + G+E L++ GD+ +
Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978
Score = 30.8 bits (68), Expect = 4.8
Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%)
Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439
+ A + L V+ +L +Q N A L +L ++K K V + G++ L+
Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577
Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494
H +L ++ + A ALR+L E ++A +V GIPA+++LL +
Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628
Query: 495 WPLVKATIGLIRNLALCPA 513
+ + G++ NL+ C A
Sbjct: 629 AEVRELVTGVLWNLSSCDA 647
>gi|53729344 plakophilin 1 isoform 1a [Homo sapiens]
Length = 726
Score = 45.8 bits (107), Expect = 1e-04
Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%)
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
I H +++ GGI LV +L SP ++V A L NL+ K+ R
Sbjct: 269 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328
Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313
+G+++ V LL + N + T L L+ ++ ++II +G
Sbjct: 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 388
Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366
+ R ++ + + L+ LS + + + G + A ++ + S
Sbjct: 389 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 448
Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421
+ V+NC+ L NLS L++ + QL + N T +TG SN + N
Sbjct: 449 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 502
Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468
N+ + L T G L H+ ++ KD E AL++LT+
Sbjct: 503 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 562
Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528
+ M+Q G+P I +LL N +V++ L+ N++ P H + V P +
Sbjct: 563 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 620
Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588
+LL T + + C +++A P + F + +
Sbjct: 621 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 666
Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638
+ L SS A +L ++ KE + +G ++ L N
Sbjct: 667 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 717
Score = 40.4 bits (93), Expect = 0.006
Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
IP V+ LSS E + + E AK V G+ K+V LL N
Sbjct: 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 306
Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
L+ L + + +KL G + V ++R
Sbjct: 307 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 341
Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400
G + K LT LW L + ++ K+E + L +L +++
Sbjct: 342 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 386
Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447
V D V ATG L NL+ ++ +T+ + +++L+ + + +
Sbjct: 387 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 446
Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507
D E +C L +L+ R +AE+ +L Y N N + K++ G N
Sbjct: 447 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 495
Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564
+ N+ PL E P+ L H DA R T + + +E C
Sbjct: 496 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 548
Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613
GAL L M+++ + +P +LL S ++ R A +L +++
Sbjct: 549 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 603
>gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo
sapiens]
Length = 625
Score = 45.8 bits (107), Expect = 1e-04
Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%)
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
I H +++ GGI LV +L SP ++V A L NL+ K+ R
Sbjct: 168 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 227
Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313
+G+++ V LL + N + T L L+ ++ ++II +G
Sbjct: 228 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 287
Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366
+ R ++ + + L+ LS + + + G + A ++ + S
Sbjct: 288 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 347
Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421
+ V+NC+ L NLS L++ + QL + N T +TG SN + N
Sbjct: 348 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 401
Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468
N+ + L T G L H+ ++ KD E AL++LT+
Sbjct: 402 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 461
Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528
+ M+Q G+P I +LL N +V++ L+ N++ P H + V P +
Sbjct: 462 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 519
Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588
+LL T + + C +++A P + F + +
Sbjct: 520 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 565
Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638
+ L SS A +L ++ KE + +G ++ L N
Sbjct: 566 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 616
Score = 40.4 bits (93), Expect = 0.006
Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%)
Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
IP V+ LSS E + + E AK V G+ K+V LL N
Sbjct: 146 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 205
Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
L+ L + + +KL G + V ++R
Sbjct: 206 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 240
Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400
G + K LT LW L + ++ K+E + L +L +++
Sbjct: 241 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 285
Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447
V D V ATG L NL+ ++ +T+ + +++L+ + + +
Sbjct: 286 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 345
Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507
D E +C L +L+ R +AE+ +L Y N N + K++ G N
Sbjct: 346 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 394
Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564
+ N+ PL E P+ L H DA R T + + +E C
Sbjct: 395 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 447
Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613
GAL L M+++ + +P +LL S ++ R A +L +++
Sbjct: 448 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 502
>gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
ARA R R A+ S +L+ Q + L ++E +L++A++ L N +
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
D LP + K+LN DP+V KA +++N LS E RR + Q+ + +
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215
Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
N+S L T H L++ +F +G +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)
Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210
Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
+ +V L+N+T N L S L A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254
>gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
ARA R R A+ S +L+ Q + L ++E +L++A++ L N +
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
D LP + K+LN DP+V KA +++N LS E RR + Q+ + +
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215
Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
N+S L T H L++ +F +G +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)
Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210
Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
+ +V L+N+T N L S L A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254
>gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]
Length = 379
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)
Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
ARA R R A+ S +L+ Q + L ++E +L++A++ L N +
Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155
Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
D LP + K+LN DP+V KA +++N LS E RR + Q+ + +
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215
Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
N+S L T H L++ +F +G +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)
Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210
Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
+ +V L+N+T N L S L A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 45.1 bits (105), Expect = 2e-04
Identities = 82/339 (24%), Positives = 143/339 (42%), Gaps = 47/339 (13%)
Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
E+ K+ D + + + A M + L+ + + +A + + + + A+V + + S+ + +
Sbjct: 449 EMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASDSE-ELHQ 507
Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVR-MLSSPVESVLFYAITTLHNLLLYQEGA 260
+SIL NLS + + ++G + ALV+ +L + ES L ++ L NL +
Sbjct: 508 VVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNLSAHSTEN 567
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
K A+ DG FL T L Y Q + L I+ +GG I+R
Sbjct: 568 KAAICQVDGALG-----------FLVST------LTYKCQSNSLAIIESGGG-----ILR 605
Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
N S L+ T +VL + +Q L +HLTS+S +V N TL NLS
Sbjct: 606 NVS--SLVATREDYRQVLR----------DHNCLQTLLQHLTSHSLTIVSNACGTLWNLS 653
Query: 381 DVATKQE------GLESVLKILV-NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433
+ + + G +L+ LV ++ + + L++ + T V+ S
Sbjct: 654 ARSARDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGS 713
Query: 434 GVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMA 472
V +L RA + + AL HL + P A A
Sbjct: 714 CVPSLYVRKQRALEAELDARHLAQALEHLEKQGPPAAEA 752
Score = 32.7 bits (73), Expect = 1.3
Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 41/253 (16%)
Query: 352 GGMQALGKHLTSNSPRLVQNCLWTLRNLS---DVATKQEGLE--SVLKILVNQLSVDDVN 406
G M+A+ L S+S L Q LRNLS D+ +K+ E SV ++ L +
Sbjct: 489 GCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKES 548
Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-----VEALIH-------AILRAG-------- 446
L L NL+ ++++NK + Q G V L + AI+ +G
Sbjct: 549 TLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVS 608
Query: 447 -------DKDDITEPAVCA---LRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWP 496
D + C L+HLTS + N+ + + A +Q W
Sbjct: 609 SLVATREDYRQVLRDHNCLQTLLQHLTSH--SLTIVSNACGTLWNLSAR-SARDQELLWD 665
Query: 497 LVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRM 556
L +G++RNL + AA + L+ HQ A V+ G+ P + VR
Sbjct: 666 L--GAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVP-SLYVRK 722
Query: 557 EEIVEGCTGALHI 569
+ +E A H+
Sbjct: 723 QRALEAELDARHL 735
>gi|189011568 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 44.3 bits (103), Expect = 4e-04
Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
+L LS E A+ + GG+ A+ +L E Y +T H + + A MA+
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508
Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
+ ++ +V L + + L+ L++ + SK + G
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568
Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
+AL++ E L + L LS C NK I G A L +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628
Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
++++ LRN+S + E +L+ L+ L + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
N K++ + + G +++ ++ + K I + ALR+L + P N +
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746
Query: 480 YGIPAI 485
+P++
Sbjct: 747 SSLPSL 752
Score = 40.8 bits (94), Expect = 0.005
Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)
Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542
Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
S+L NLS + + + G + AL+ L ES L ++ L NL +
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
K + DG FL T L Y +Q + L I+ +GG I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640
Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
N S +++ ++ + E +Q L +HL S+S +V N TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 381 DVATKQE------GLESVLKILVN 398
K + G S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712
>gi|189011566 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 44.3 bits (103), Expect = 4e-04
Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
+L LS E A+ + GG+ A+ +L E Y +T H + + A MA+
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508
Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
+ ++ +V L + + L+ L++ + SK + G
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568
Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
+AL++ E L + L LS C NK I G A L +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628
Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
++++ LRN+S + E +L+ L+ L + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
N K++ + + G +++ ++ + K I + ALR+L + P N +
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746
Query: 480 YGIPAI 485
+P++
Sbjct: 747 SSLPSL 752
Score = 40.8 bits (94), Expect = 0.005
Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)
Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542
Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
S+L NLS + + + G + AL+ L ES L ++ L NL +
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
K + DG FL T L Y +Q + L I+ +GG I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640
Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
N S +++ ++ + E +Q L +HL S+S +V N TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 381 DVATKQE------GLESVLKILVN 398
K + G S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712
>gi|53759122 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 44.3 bits (103), Expect = 4e-04
Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
+L LS E A+ + GG+ A+ +L E Y +T H + + A MA+
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508
Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
+ ++ +V L + + L+ L++ + SK + G
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568
Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
+AL++ E L + L LS C NK I G A L +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628
Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
++++ LRN+S + E +L+ L+ L + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
N K++ + + G +++ ++ + K I + ALR+L + P N +
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746
Query: 480 YGIPAI 485
+P++
Sbjct: 747 SSLPSL 752
Score = 40.8 bits (94), Expect = 0.005
Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)
Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542
Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
S+L NLS + + + G + AL+ L ES L ++ L NL +
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602
Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
K + DG FL T L Y +Q + L I+ +GG I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640
Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
N S +++ ++ + E +Q L +HL S+S +V N TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688
Query: 381 DVATKQE------GLESVLKILVN 398
K + G S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 43.9 bits (102), Expect = 5e-04
Identities = 94/413 (22%), Positives = 159/413 (38%), Gaps = 78/413 (18%)
Query: 270 LQKMVPLLNKNNPK--FLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKL 327
L +++ +N ++P F A T L N KL+I A P+ +V+ +++ Y L
Sbjct: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPR-MVEFLKSSLYPCL 130
Query: 328 LWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSN---------------------- 364
+ + L + S A+VE G +Q L + L+S+
Sbjct: 131 QFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190
Query: 365 -----------------SPRL----VQNCLWTLRNL--------SDVATKQEGLESVLKI 395
SP L ++N WTL NL D A KQ +L
Sbjct: 191 RDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ-----ILPA 245
Query: 396 LVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPA 455
L++ L D VL+ A LS LT ++K V N+GV + ++ + + + +T
Sbjct: 246 LLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVV-NTGVLPRLVVLMTSSELNVLTPSL 304
Query: 456 VCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANH 515
+T + +MA ++ LN ++ L Q N+ + K + N+A P +H
Sbjct: 305 RTVGNIVTGTDEQTQMAIDAGMLN-----VLPQLLQHNKPSIQKEAAWALSNVAAGPCHH 359
Query: 516 -APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVE----GCTGALHIL 570
L V+P LV LL Q+ A + G M+++++ G L L
Sbjct: 360 IQQLLAYDVLPPLVALLKNGEFKVQKE-AVWMVANFATGATMDQLIQLVHSGVLEPLVNL 418
Query: 571 ARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDA 623
P ++ + L+ I +Q E LC L ++ D I+A
Sbjct: 419 LTAPDVKIVLIILDVISCILQAAEKRSEKEN------LCLLIEELGGIDRIEA 465
Score = 35.0 bits (79), Expect = 0.25
Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 4/230 (1%)
Query: 222 IFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN 280
+ S IP L+ ++S + IT TL NL + + L ++ LL
Sbjct: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253
Query: 281 NPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSV 340
+ + L+ L L G+ + ++ G LV +M + L + V +++
Sbjct: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313
Query: 341 CPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVA---TKQEGLESVLKILV 397
++AG + L + L N P + + W L N++ +Q VL LV
Sbjct: 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLV 373
Query: 398 NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGD 447
L + V A ++N + ++ + +SGV + +L A D
Sbjct: 374 ALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423
Score = 33.1 bits (74), Expect = 0.96
Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 580 IFRLNTIPLFVQLLYSSVEN-IQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
+ IP V+ L SS+ +Q AA L +A E A+ GA PL+ELL S
Sbjct: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
Query: 638 NEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKH 675
N A L I+ D P++R V +T++ H
Sbjct: 169 NVAVCEQAVWALGNIAGD-GPEFRDNV---ITSNAIPH 202
>gi|6005830 plakophilin 3 [Homo sapiens]
Length = 797
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)
Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLW 329
L V L ++P + +Q Y + +K + LV++ + + E
Sbjct: 321 LPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRH 380
Query: 330 TTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDV-----AT 384
T + ++ NK A+VE G+ L + L L +N L NLS
Sbjct: 381 ATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRL 440
Query: 385 KQEGLESVLKILVNQLS-----------VDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433
++ LE + ++++ LS + + ATG L NL+ + + + +
Sbjct: 441 ARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECH 500
Query: 434 G-VEALIHAILRAGD----KDDITEPAVCALRHLTSR 465
G V+AL+ +I A D +D E AVC LR+L+ R
Sbjct: 501 GLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYR 537
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 40.8 bits (94), Expect = 0.005
Identities = 92/422 (21%), Positives = 160/422 (37%), Gaps = 66/422 (15%)
Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
+ +V LLN + + L T L + Y + E + + GG Q ++ +R+ +
Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
EKLL ++ + S + ++ G + L K L + L + CL NL+
Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211
Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
++ + +E E ++K+ Q+ D ++ L+ N K + +
Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267
Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
VE L+ + + D +DDITE V L S E + SV R+ IP
Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327
Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
+ N L A I N A AN + + ++ +L+ LL RHV
Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372
Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
G + AL LA +N+ ++ ++ L S + +Q
Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
G L L +EAA+ + G + L+E L H+ G + + L R S+
Sbjct: 423 LLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
Query: 656 KN 657
K+
Sbjct: 480 KD 481
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 39.3 bits (90), Expect = 0.013
Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 266 LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSY 324
L D K + + PK+L C LL Y + E K +IL P ++R S
Sbjct: 223 LLDFYMKNILMSKVKPPKYLL--DSCAPLLRYLSHSEFKDLIL----PTIQKSLLR--SP 274
Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVAT 384
E ++ T S +L +++ S + G L HL SNSPRL+ + LRNL+ +
Sbjct: 275 ENVIETISSLLASVTLDLSQYAMDIVKG----LAGHLKSNSPRLMDEAVLALRNLARQCS 330
Query: 385 KQEGLESVLKIL 396
+ES+ K L
Sbjct: 331 DSSAMESLTKHL 342
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 38.1 bits (87), Expect = 0.030
Identities = 77/365 (21%), Positives = 139/365 (38%), Gaps = 32/365 (8%)
Query: 107 EGQATNLQRLAEPSQLLKSAIVHLIN-------------YQDDAELATRALPELTKLLND 153
E + L++ QL K V LIN Y + E+ ++L
Sbjct: 32 EEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFS 91
Query: 154 EDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQN----TSDLDTARCTTS 207
+D + +L KE S ++ +P++V V ++ T + A T+
Sbjct: 92 DDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTN 151
Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
I S + + ++G +P + +L+S E V A+ L N+ + V
Sbjct: 152 IASGTSQQTK---IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNC 208
Query: 268 DGLQKMVPLLNKNNPKFLAITTDC---LQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
L ++ LL K+ L +T + L L G + L +++ + S
Sbjct: 209 SILNPLLTLLTKSTR--LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFS-SD 265
Query: 325 EKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL---S 380
LL L LS P+ K A++++G + L + L N ++ L + N+
Sbjct: 266 SDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGD 325
Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIH 440
D+ T+ S L L++ LS ++ A T+SN+T N V + LI
Sbjct: 326 DIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIE 385
Query: 441 AILRA 445
+ +A
Sbjct: 386 ILQKA 390
Score = 31.2 bits (69), Expect = 3.7
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAA-DAIDAEGASAPLMELLHSRN 638
+ +P+F++LL S E++Q A L +A D D + PL+ LL
Sbjct: 163 VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKST 222
Query: 639 EGTATYAAA-VLFRISEDKNP 658
T T A L + KNP
Sbjct: 223 RLTMTRNAVWALSNLCRGKNP 243
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 37.7 bits (86), Expect = 0.039
Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)
Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
+ +V LLN + + L T L + Y + E + + GG Q ++ +R+ +
Sbjct: 91 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150
Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
EKLL ++ + S + ++ G + L K L + L + CL NL+
Sbjct: 151 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 210
Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
++ + +E E ++K+ Q+ D ++ L+ N K + +
Sbjct: 211 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 266
Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
VE L+ + + D +DDITE V L S E + SV R+ IP
Sbjct: 267 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 326
Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
+ N L A I N A AN + + ++ +L+ LL RHV
Sbjct: 327 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 371
Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
G + AL LA +N+ ++ ++ L S + +Q
Sbjct: 372 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421
Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
G L L + A+A + G + L+E L H+ G + + L R S+
Sbjct: 422 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
Query: 656 KN 657
K+
Sbjct: 480 KD 481
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 37.7 bits (86), Expect = 0.039
Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)
Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
+ +V LLN + + L T L + Y + E + + GG Q ++ +R+ +
Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
EKLL ++ + S + ++ G + L K L + L + CL NL+
Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211
Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
++ + +E E ++K+ Q+ D ++ L+ N K + +
Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267
Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
VE L+ + + D +DDITE V L S E + SV R+ IP
Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327
Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
+ N L A I N A AN + + ++ +L+ LL RHV
Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372
Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
G + AL LA +N+ ++ ++ L S + +Q
Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
G L L + A+A + G + L+E L H+ G + + L R S+
Sbjct: 423 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 480
Query: 656 KN 657
K+
Sbjct: 481 KD 482
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,267,538
Number of Sequences: 37866
Number of extensions: 1081431
Number of successful extensions: 2939
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 2614
Number of HSP's gapped (non-prelim): 255
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.