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Search of human proteins with 24797101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
(489 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 972 0.0
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 972 0.0
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 972 0.0
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 555 e-158
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 152 9e-37
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 151 1e-36
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 142 9e-34
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 142 9e-34
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 139 6e-33
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 131 1e-30
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 123 4e-28
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 115 9e-26
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 115 9e-26
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 114 2e-25
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 114 2e-25
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 114 2e-25
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 110 2e-24
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 105 7e-23
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 105 7e-23
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 100 5e-21
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 100 5e-21
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 98 1e-20
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 98 1e-20
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 96 1e-19
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 96 1e-19
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 96 1e-19
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 92 8e-19
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 92 8e-19
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 92 1e-18
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 91 3e-18
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 973 bits (2514), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 1 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60
MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI
Sbjct: 769 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 828
Query: 61 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120
DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS
Sbjct: 829 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 888
Query: 121 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180
AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK
Sbjct: 889 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 948
Query: 181 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240
HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ
Sbjct: 949 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 1008
Query: 241 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300
MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK
Sbjct: 1009 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 1068
Query: 301 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL
Sbjct: 1069 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1128
Query: 361 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420
KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT
Sbjct: 1129 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 1188
Query: 421 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS
Sbjct: 1189 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1248
Query: 481 LRIEPKLPT 489
LRIEPKLPT
Sbjct: 1249 LRIEPKLPT 1257
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 973 bits (2514), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 1 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60
MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI
Sbjct: 785 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 844
Query: 61 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120
DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS
Sbjct: 845 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 904
Query: 121 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180
AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK
Sbjct: 905 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 964
Query: 181 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240
HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ
Sbjct: 965 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 1024
Query: 241 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300
MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK
Sbjct: 1025 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 1084
Query: 301 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL
Sbjct: 1085 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144
Query: 361 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420
KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT
Sbjct: 1145 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 1204
Query: 421 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS
Sbjct: 1205 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
Query: 481 LRIEPKLPT 489
LRIEPKLPT
Sbjct: 1265 LRIEPKLPT 1273
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 973 bits (2514), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 1 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60
MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI
Sbjct: 1 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60
Query: 61 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120
DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS
Sbjct: 61 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120
Query: 121 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180
AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK
Sbjct: 121 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180
Query: 181 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240
HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ
Sbjct: 181 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240
Query: 241 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300
MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK
Sbjct: 241 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300
Query: 301 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL
Sbjct: 301 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
Query: 361 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420
KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT
Sbjct: 361 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420
Query: 421 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS
Sbjct: 421 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
Query: 481 LRIEPKLPT 489
LRIEPKLPT
Sbjct: 481 LRIEPKLPT 489
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 555 bits (1431), Expect = e-158
Identities = 278/445 (62%), Positives = 346/445 (77%), Gaps = 28/445 (6%)
Query: 44 ALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVM 103
++ K E + + + ++ + + D TE SP +SP+TP+ ++ +
Sbjct: 820 SIQKAVLESAPADRAGVESSPAAD-TTELSPCRSPSTPRHLRYRQPGG------------ 866
Query: 104 TSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIR 163
+ DN ++S ASAFAIATA A G+P GF +R DKEF+IR
Sbjct: 867 ---QTADNAHCSVSPASAFAIATAAAGHGSP------------PGFNNTERTCDKEFIIR 911
Query: 164 RAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTL 223
R ATNRVLNVLRHWVSKH+QDFE N+ELK V+ LEEV+ DP+LL QERKAAANI+R L
Sbjct: 912 RTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL 971
Query: 224 TQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGW 283
+Q+D D + LE+I QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQGW
Sbjct: 972 SQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
Query: 284 MKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYN 343
MKL+KNERTPYIMKT++HFND+SNL+AS+I+ D+++R +AIEKWVAVADICRCLHNYN
Sbjct: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
Query: 344 AVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCV 403
VLEITS++NRSAI+RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP V
Sbjct: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
Query: 404 PYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQY 463
PYLGMYLTDLAFIEEGTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV QY
Sbjct: 1152 PYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQY 1211
Query: 464 LLDQSFVMDEESLYESSLRIEPKLP 488
LLD+ ++DE++LYE SL+IEP+LP
Sbjct: 1212 LLDKDLIIDEDTLYELSLKIEPRLP 1236
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 152 bits (383), Expect = 9e-37
Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)
Query: 152 DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 211
D + KE+V + R+LNV RHWV H DFE + EL ++ F+ V + + +
Sbjct: 671 DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726
Query: 212 ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 262
++ A IIR Q + IT E E ++P FE + EIA QL
Sbjct: 727 WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786
Query: 263 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 322
TLL+ +++K+ E G W K +K +P ++K +H +++ I+ E+ R
Sbjct: 787 TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846
Query: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382
V+ + + + + + + L+N+N VLEI S++N +++RL T+ + ++ + ++D+ +L
Sbjct: 847 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905
Query: 383 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 439
S+ FK LK+ +PPCVP+ G+YLT++ EEG ++ + L+NFSK R ++
Sbjct: 906 -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964
Query: 440 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 486
I EI+Q+Q Y + + + ++ L ++E L+ SL IEP+
Sbjct: 965 ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 151 bits (382), Expect = 1e-36
Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 221
RVLNV RHWV H DFE + L ++ F+ V E +T+ +RK A
Sbjct: 688 RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744
Query: 222 TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 274
PG N IT + E + P + +EIA QLTLL+ +++ +
Sbjct: 745 ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800
Query: 275 YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 334
E G W K +K +P ++K +H +++ I+ E++ RV+ + + + +
Sbjct: 801 PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860
Query: 335 ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 394
+ + L+N+N VLE+ S+MN S ++RL T+ ++ + K ++++ +L SE +K
Sbjct: 861 VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918
Query: 395 LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 451
L++ +PPCVP+ G+YLT++ EEG P + L+NFSK R ++ I EI+Q+Q
Sbjct: 919 LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978
Query: 452 YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 488
Y + ++ + ++ L M++E L+ SL IEP+ P
Sbjct: 979 YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 142 bits (357), Expect = 9e-34
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 242 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 299
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 844 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901
Query: 300 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 359
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 902 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
Query: 360 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 419
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 962 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016
Query: 420 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 479
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075
Query: 480 SLRIEPK 486
SL+I+P+
Sbjct: 1076 SLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 142 bits (357), Expect = 9e-34
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 242 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 299
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 826 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 883
Query: 300 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 359
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 884 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 943
Query: 360 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 419
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 944 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 998
Query: 420 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 479
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 999 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1057
Query: 480 SLRIEPK 486
SL+I+P+
Sbjct: 1058 SLKIKPR 1064
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 139 bits (350), Expect = 6e-33
Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)
Query: 137 EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 194
++Y ++ + Q + + + VIR N + ++LR W+ + ++DF C K
Sbjct: 150 DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205
Query: 195 VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 245
++ +L +M DPE + A N++ +++ P +LEE ++ G
Sbjct: 206 LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259
Query: 246 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 302
AE F S +AEQLT +D +FKK+ G W + +K E P I T F
Sbjct: 260 SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
Query: 303 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
N ++ + S I+ +++ R IEKW+ +A CR L N++++ I S++ ++I+RL
Sbjct: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
Query: 361 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 402
KKTW V + + ++L ++L+ EG +F NL ++K
Sbjct: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
Query: 403 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 449
VPYLG +LTDL ++ +Y E GL+NF K R +I +I+ Q
Sbjct: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
Query: 450 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 484
+Y + K Q+ Q + +EES Y S IE
Sbjct: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 131 bits (330), Expect = 1e-30
Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)
Query: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
E A Q+TL+D VFK I +E GW K EK P + T+ FN +S + EI+
Sbjct: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
Query: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
+ + R + ++ A L+N +A++ + S + + IFRL KTW +S++ K +
Sbjct: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
Query: 377 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 435
KL+ ++S E +K LR+ + + PC+PYLG+YL+DL +I+ P+ T L N +
Sbjct: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
Query: 436 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 489
++++I+R I QQ+ Y I V +YL ++ + E+ Y+ SL+IEP T
Sbjct: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 123 bits (308), Expect = 4e-28
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)
Query: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
E A Q+TL+D VFK I EE GW K EK+ P ++ T+ FN +S + EI+
Sbjct: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
Query: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
+ + R + +V +A L+N ++++ + S++ + IFRL KTW ++++ K +
Sbjct: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
Query: 377 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 435
KL L+S E +K RE +++ P +PYLG+YL DL +I+ P + + N +
Sbjct: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
Query: 436 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 485
+++I+R I Q T ++ K +Y+ + Q FV D+ Y+ SLRIEP
Sbjct: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 115 bits (288), Expect = 9e-26
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 170 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 210
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
Query: 211 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 267
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
Query: 268 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 322
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
Query: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
Query: 383 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 422
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
Query: 423 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
Query: 481 LRIEP 485
IEP
Sbjct: 500 RVIEP 504
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 115 bits (288), Expect = 9e-26
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 170 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 210
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
Query: 211 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 267
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
Query: 268 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 322
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
Query: 323 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 382
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
Query: 383 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 422
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
Query: 423 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
Query: 481 LRIEP 485
IEP
Sbjct: 500 RVIEP 504
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 228
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 229 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 288
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 289 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 348
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 349 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 408
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 467
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 468 SFVMDEESLYESSLRIEPK 486
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 228
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 229 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 288
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 289 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 348
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 349 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 408
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 467
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 468 SFVMDEESLYESSLRIEPK 486
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 228
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 229 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 288
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 289 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 348
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 349 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 408
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 467
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 468 SFVMDEESLYESSLRIEPK 486
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 110 bits (276), Expect = 2e-24
Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
++A +L D +F I +E + + E T + + N++ +A+EI+
Sbjct: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
Query: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
+ RV ++K++ +A C+ N N+ I +N +++ RL +TW K+ + K L
Sbjct: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
Query: 377 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 436
+L+ L K R+A K PP +P++ + L D+ FI EG + D LVNF K+ M
Sbjct: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676
Query: 437 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 487
I+ +R +R QF + K EHQ ++ Y+ + +++L+E S RIEP++
Sbjct: 677 IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 105 bits (263), Expect = 7e-23
Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)
Query: 258 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 314
+AEQ TL+D +FKK+ G W + +K + P I T FN ++N + + +
Sbjct: 390 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 449
Query: 315 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 372
N A R +E W+ VA CR L N++++ I S++ ++I RLKKTW VS+ +
Sbjct: 450 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 509
Query: 373 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 408
+ KL ++ S E + RE L +P VPYLG
Sbjct: 510 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 569
Query: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 466
+LTDL ++ +Y L+NF K R +I +I+ Q Y I + +
Sbjct: 570 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 629
Query: 467 QSFVMDEESLYESSLRIEP 485
+ + ES Y S +EP
Sbjct: 630 VERLSETES-YNLSCELEP 647
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 105 bits (263), Expect = 7e-23
Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)
Query: 258 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 314
+AEQ TL+D +FKK+ G W + +K + P I T FN ++N + + +
Sbjct: 335 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
Query: 315 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 372
N A R +E W+ VA CR L N++++ I S++ ++I RLKKTW VS+ +
Sbjct: 395 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
Query: 373 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 408
+ KL ++ S E + RE L +P VPYLG
Sbjct: 455 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
Query: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 466
+LTDL ++ +Y L+NF K R +I +I+ Q Y I + +
Sbjct: 515 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
Query: 467 QSFVMDEESLYESSLRIEP 485
+ + ES Y S +EP
Sbjct: 575 VERLSETES-YNLSCELEP 592
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 99.8 bits (247), Expect = 5e-21
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
Query: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
Query: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
Query: 430 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 483
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
Query: 484 EPKLP 488
EP+ P
Sbjct: 863 EPRRP 867
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 99.8 bits (247), Expect = 5e-21
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 768 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827
Query: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 828 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887
Query: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 888 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946
Query: 430 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 483
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 947 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 1006
Query: 484 EPKLP 488
EP+ P
Sbjct: 1007 EPRRP 1011
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 98.2 bits (243), Expect = 1e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 430 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 486
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 98.2 bits (243), Expect = 1e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 250 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 309
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 370 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 429
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 430 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 486
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 226
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 227 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 286
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 287 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 346
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 347 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 406
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 407 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 465 ---LDQSFVMDEESLYESSLRIEPK 486
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 226
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 227 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 286
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 287 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 346
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 347 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 406
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 407 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 465 ---LDQSFVMDEESLYESSLRIEPK 486
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 226
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 227 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 286
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 287 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 346
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 347 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 406
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 407 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 465 ---LDQSFVMDEESLYESSLRIEPK 486
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)
Query: 258 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 305
+A+QLT H+ +++ Y E F Q +++ + N+++ Y K T++ FN +
Sbjct: 209 LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265
Query: 306 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 365
S L+A+EI R IE ++ VA C + N+N+++ I S MN S + RLKKTW
Sbjct: 266 SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325
Query: 366 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 414
KV A D L+ + F N R AL+ + +P+ + + D+
Sbjct: 326 KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382
Query: 415 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 474
F+ EG N +G VNF K ++ + E ++Q E K+ QYLL V E+
Sbjct: 383 FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441
Query: 475 SLYESSLRIE 484
+LY +S E
Sbjct: 442 ALYLASYESE 451
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)
Query: 258 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 314
+AEQLTL+D +FKK+ E G W + L+ NE P + T HFN ++N I + +
Sbjct: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
Query: 315 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 372
+ + AR A +E W+ VA C L+N+++V I S++ + I +L KTW VS ++
Sbjct: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
Query: 373 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 415
+ +L K L+ G FK ++ L+ VP+LG +LT+L
Sbjct: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
Query: 416 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 473
++ P+ + N +K +++E++ Q A Y++ K Y + D+
Sbjct: 403 LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459
Query: 474 ESLYESSLRIEPKLP 488
ES Y+ S ++EP+ P
Sbjct: 460 ES-YKLSCQLEPENP 473
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 91.7 bits (226), Expect = 1e-18
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)
Query: 254 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 313
S +E+A QL++ + +F+ I E+ KL + + + N + +ASEI
Sbjct: 717 STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775
Query: 314 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 373
+R + R+ I+ ++ +A CR N+N++ I S +N + + RL+ TW K+ + +
Sbjct: 776 LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835
Query: 374 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 431
L LQ L R L +N PP +P + DL F+ EG + DGLVNF
Sbjct: 836 LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894
Query: 432 SKMRMISHIIREI 444
K+RMI+ IR +
Sbjct: 895 EKLRMIAKEIRHV 907
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 90.5 bits (223), Expect = 3e-18
Identities = 73/260 (28%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 244 GVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK--------NERTPYI 295
GV ++P+ +A+QLT ++ + I EEF Q ++ + +++T +
Sbjct: 196 GVCSDPYT------LAQQLTHVELERLRHIGPEEFV-QAFVNKDPLASTKPCFSDKTSNL 248
Query: 296 MKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRS 355
K FN + L+A+EI R IE ++ VA C + N+N+++ I S MN S
Sbjct: 249 EAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMS 308
Query: 356 AIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVP 404
+ RLKKTW KV + K I L+ + G F N R AL+ + +P
Sbjct: 309 PVSRLKKTWAKV-RTAKFFI--LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIP 365
Query: 405 YLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
+ + + D+ F+ EG N +G VNF K ++ + E ++Q E A +T YL
Sbjct: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYL 425
Query: 465 LDQSFVMDEESLYESSLRIE 484
+ E+ LY +S E
Sbjct: 426 YTAP-IFSEDGLYLASYESE 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,623,091
Number of Sequences: 37866
Number of extensions: 751115
Number of successful extensions: 3019
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 2819
Number of HSP's gapped (non-prelim): 249
length of query: 489
length of database: 18,247,518
effective HSP length: 106
effective length of query: 383
effective length of database: 14,233,722
effective search space: 5451515526
effective search space used: 5451515526
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.