Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 24797099

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24797099 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 1 [Homo sapiens]
         (1273 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...  2526   0.0  
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...  2479   0.0  
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...  1634   0.0  
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...   972   0.0  
gi|154689780 son of sevenless homolog 2 [Homo sapiens]                152   3e-36
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                 151   3e-36
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...   142   3e-33
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...   142   3e-33
gi|93102367 ral guanine nucleotide dissociation stimulator-like ...   139   2e-32
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...   131   4e-30
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ...   123   1e-27
gi|239582765 ral guanine nucleotide dissociation stimulator-like...   115   3e-25
gi|239582763 ral guanine nucleotide dissociation stimulator-like...   115   3e-25
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...   114   5e-25
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...   114   5e-25
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...   114   5e-25
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom...   110   7e-24
gi|24307909 ral guanine nucleotide dissociation stimulator isofo...   105   2e-22
gi|108796058 ral guanine nucleotide dissociation stimulator isof...   105   2e-22
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof...   100   2e-20
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof...   100   2e-20
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    98   4e-20
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    98   4e-20
gi|118150678 epithelial cell transforming sequence 2 oncogene-li...    96   2e-19
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              96   3e-19
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             96   3e-19
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             96   3e-19
gi|22749129 RasGEF domain family, member 1B [Homo sapiens]             92   2e-18
gi|23957680 ral guanine nucleotide dissociation stimulator-like ...    92   2e-18
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     92   4e-18

>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 2526 bits (6547), Expect = 0.0
 Identities = 1273/1273 (100%), Positives = 1273/1273 (100%)

Query: 1    MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
            MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
Sbjct: 1    MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60

Query: 61   RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
            RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
Sbjct: 61   RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120

Query: 121  VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
            VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
Sbjct: 121  VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180

Query: 181  LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
            LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
Sbjct: 181  LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240

Query: 241  RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
            RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
Sbjct: 241  RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300

Query: 301  QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
            QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
Sbjct: 301  QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360

Query: 361  KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
            KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS
Sbjct: 361  KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420

Query: 421  RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
            RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
Sbjct: 421  RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480

Query: 481  SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
            SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
Sbjct: 481  SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540

Query: 541  QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
            QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
Sbjct: 541  QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600

Query: 601  KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660
            KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
Sbjct: 601  KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660

Query: 661  TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720
            TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN
Sbjct: 661  TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720

Query: 721  KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780
            KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN
Sbjct: 721  KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780

Query: 781  GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840
            GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE
Sbjct: 781  GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840

Query: 841  ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900
            ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL
Sbjct: 841  ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900

Query: 901  SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960
            SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH
Sbjct: 901  SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960

Query: 961  WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020
            WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE
Sbjct: 961  WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020

Query: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080
            EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM
Sbjct: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080

Query: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140
            KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA
Sbjct: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140

Query: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200
            IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI
Sbjct: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200

Query: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260
            EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL
Sbjct: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260

Query: 1261 YESSLRIEPKLPT 1273
            YESSLRIEPKLPT
Sbjct: 1261 YESSLRIEPKLPT 1273


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 2479 bits (6425), Expect = 0.0
 Identities = 1257/1273 (98%), Positives = 1257/1273 (98%), Gaps = 16/1273 (1%)

Query: 1    MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
            MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
Sbjct: 1    MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60

Query: 61   RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
            RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
Sbjct: 61   RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120

Query: 121  VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
            VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
Sbjct: 121  VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180

Query: 181  LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
            LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
Sbjct: 181  LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240

Query: 241  RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
            RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
Sbjct: 241  RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300

Query: 301  QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
            QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
Sbjct: 301  QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360

Query: 361  KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
            KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS
Sbjct: 361  KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420

Query: 421  RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
            RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
Sbjct: 421  RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480

Query: 481  SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
            SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
Sbjct: 481  SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540

Query: 541  QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
            QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
Sbjct: 541  QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600

Query: 601  KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660
            KVTVPQMIK             SDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
Sbjct: 601  KVTVPQMIK-------------SDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 647

Query: 661  TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720
            TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPA   RSLELLFASGQNN
Sbjct: 648  TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPA---RSLELLFASGQNN 704

Query: 721  KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780
            KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN
Sbjct: 705  KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 764

Query: 781  GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840
            GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE
Sbjct: 765  GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 824

Query: 841  ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900
            ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL
Sbjct: 825  ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 884

Query: 901  SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960
            SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH
Sbjct: 885  SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 944

Query: 961  WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020
            WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE
Sbjct: 945  WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1004

Query: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080
            EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM
Sbjct: 1005 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1064

Query: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140
            KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA
Sbjct: 1065 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1124

Query: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200
            IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI
Sbjct: 1125 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1184

Query: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260
            EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL
Sbjct: 1185 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1244

Query: 1261 YESSLRIEPKLPT 1273
            YESSLRIEPKLPT
Sbjct: 1245 YESSLRIEPKLPT 1257


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score = 1634 bits (4232), Expect = 0.0
 Identities = 839/1286 (65%), Positives = 1009/1286 (78%), Gaps = 64/1286 (4%)

Query: 1    MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
            MQK +R N+GH   L  LARK+GT++G+LSK++++ ++W  KWFAL QN+LFYFE + S 
Sbjct: 1    MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60

Query: 61   RPSGLYLLEGCVCDRAPSPKPALSA----KEPLEKQHYFTVNFSHENQKALELRTEDAKD 116
            RP+G+YLLEGC C+R P+P  A +     ++ L+KQ+YFTV F HE QK LELR E+ +D
Sbjct: 61   RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120

Query: 117  CDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKA 176
              EW+ AI  ASY  +  E E LMQKY+HL+QIVETEK  A QLR Q+ED + EIERLK+
Sbjct: 121  GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180

Query: 177  EITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHAD 236
            EI +L K  ER++  Q+    DED DIKKIKKVQSF+RGWLCRRKWKTI+QDYI SPHA+
Sbjct: 181  EIIALNKTKERMRPYQS-NQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAE 239

Query: 237  SMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETI 296
            SMRKRNQ+VF+M+EAE+EYV QL+ILVN FLRPLRMAASSKKPPI+HDDVSSIFLNSETI
Sbjct: 240  SMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETI 299

Query: 297  MFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDF 356
            MFLH+IF+QGLKARI++WPTL+LADLFDILLPMLNIYQEFVRNHQYSLQ+LA+CKQNRDF
Sbjct: 300  MFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDF 359

Query: 357  DKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKL 416
            DKLLK YEA P CE R LETFLTYPMFQIPRYI+TLHELLAHTPHEHVER SL++AKSKL
Sbjct: 360  DKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKL 419

Query: 417  EELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITR 476
            EELSR+MHDEVS+TENIRKNLAIERMI+EGC+ILLDTSQTF+RQGSLIQVP  E+GK+++
Sbjct: 420  EELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSK 479

Query: 477  GRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTK-NGVISLIDCTLLEEPESTEEE 535
             RLGSLSLKKEGERQCFLF+KH +ICTR SGGKLHL K  GV+SLIDCTL+EEP++++++
Sbjct: 480  VRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDD 539

Query: 536  AKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNA 595
            +KGSGQ   HLDFKI VEP D+  FTV+L+A SRQEKAAW SDISQCVDNIRCNGLM   
Sbjct: 540  SKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIV 599

Query: 596  FEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVER 655
            FEENSKVTVP MIK             SDA L+ DD DI FSKT+NSCKV QIRYASVER
Sbjct: 600  FEENSKVTVPHMIK-------------SDARLHKDDTDICFSKTLNSCKVPQIRYASVER 646

Query: 656  LLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFA 715
            LLERLTDLRFLSIDFLNTFLH+YR+FTTA VVL KL  IYK+P ++IP   +RSLEL FA
Sbjct: 647  LLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIP---VRSLELFFA 703

Query: 716  SGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAAL 775
            + QNN+  +    KSPR  RKFSSPPPL++++TSSP R RKLSL  P+ +   ALDL   
Sbjct: 704  TSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTS 763

Query: 776  SCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALS----- 830
            S  +       +  SP +     T ++ +  S     P++   T E+  D   +      
Sbjct: 764  SSPTT------TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKL 817

Query: 831  KQSSEVSMREESDIDQ---NQSDDGD-TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVV 886
            K+S + ++ E +  D+     S   D TE SP +SP+TP+ ++ +               
Sbjct: 818  KRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGG----------- 866

Query: 887  MTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVI 946
                +  DN   ++S ASAFAIATA A  G+P             GF   +R  DKEF+I
Sbjct: 867  ----QTADNAHCSVSPASAFAIATAAAGHGSP------------PGFNNTERTCDKEFII 910

Query: 947  RRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRT 1006
            RR ATNRVLNVLRHWVSKH+QDFE N+ELK  V+  LEEV+ DP+LL QERKAAANI+R 
Sbjct: 911  RRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRA 970

Query: 1007 LTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQG 1066
            L+Q+D  D  + LE+I QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQG
Sbjct: 971  LSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQG 1030

Query: 1067 WMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNY 1126
            WMKL+KNERTPYIMKT++HFND+SNL+AS+I+   D+++R +AIEKWVAVADICRCLHNY
Sbjct: 1031 WMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNY 1090

Query: 1127 NAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPC 1186
            N VLEITS++NRSAI+RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP 
Sbjct: 1091 NGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPA 1150

Query: 1187 VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQ 1246
            VPYLGMYLTDLAFIEEGTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV Q
Sbjct: 1151 VPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQ 1210

Query: 1247 YLLDQSFVMDEESLYESSLRIEPKLP 1272
            YLLD+  ++DE++LYE SL+IEP+LP
Sbjct: 1211 YLLDKDLIIDEDTLYELSLKIEPRLP 1236


>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 2 [Homo sapiens]
          Length = 489

 Score =  973 bits (2514), Expect = 0.0
 Identities = 489/489 (100%), Positives = 489/489 (100%)

Query: 785  MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 844
            MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI
Sbjct: 1    MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60

Query: 845  DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 904
            DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS
Sbjct: 61   DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120

Query: 905  AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 964
            AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK
Sbjct: 121  AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180

Query: 965  HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 1024
            HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ
Sbjct: 181  HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240

Query: 1025 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 1084
            MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK
Sbjct: 241  MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300

Query: 1085 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144
            HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL
Sbjct: 301  HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360

Query: 1145 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 1204
            KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT
Sbjct: 361  KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420

Query: 1205 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
            PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS
Sbjct: 421  PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480

Query: 1265 LRIEPKLPT 1273
            LRIEPKLPT
Sbjct: 481  LRIEPKLPT 489


>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
          Length = 1332

 Score =  152 bits (383), Expect = 3e-36
 Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)

Query: 936  DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 995
            D +   KE+V  +    R+LNV RHWV  H  DFE + EL  ++  F+  V    + + +
Sbjct: 671  DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726

Query: 996  ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 1046
              ++ A IIR   Q       + IT E      E   ++P  FE    +     EIA QL
Sbjct: 727  WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786

Query: 1047 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 1106
            TLL+  +++K+   E  G  W K +K   +P ++K  +H  +++      I+  E+   R
Sbjct: 787  TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846

Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
            V+ + + + +  + + L+N+N VLEI S++N  +++RL  T+  + ++ + ++D+  +L 
Sbjct: 847  VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905

Query: 1167 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 1223
             S+  FK     LK+ +PPCVP+ G+YLT++   EEG  ++ +     L+NFSK R ++ 
Sbjct: 906  -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964

Query: 1224 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 1270
            I  EI+Q+Q   Y +  +  + ++   L       ++E    L+  SL IEP+
Sbjct: 965  ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 46/217 (21%), Positives = 88/217 (40%), Gaps = 30/217 (13%)

Query: 489 ERQCFLFSKHLIICTRGSGG-KLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLD 547
           ER  FLF   +I C    G  +L    +    L +  ++ + +  ++E        D  +
Sbjct: 456 ERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKE--------DTCE 507

Query: 548 FKIGVEPKDSPPFTVILVASSRQEKAAWTSDI-----SQCVDNIRCNGLMMNAFEENSKV 602
            K   E       ++I  A S +EK  W + +        +D +  + L+    E+  ++
Sbjct: 508 HKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRL 567

Query: 603 TVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQI-RYASVERLLERLT 661
             P++ +   + + E               +I F   + S   + I +  +V +L+ERLT
Sbjct: 568 PSPEVYRFVVKDSEE---------------NIVFEDNLQSRSGIPIIKGGTVVKLIERLT 612

Query: 662 DLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698
              +   +F+ TFL +YR F     +L  LI  ++ P
Sbjct: 613 YHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIP 649


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score =  151 bits (382), Expect = 3e-36
 Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 1005
            RVLNV RHWV  H  DFE +  L  ++  F+  V         E +T+  +RK  A    
Sbjct: 688  RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744

Query: 1006 TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 1058
                  PG N IT +      E   + P    +        +EIA QLTLL+  +++ + 
Sbjct: 745  ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800

Query: 1059 YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 1118
              E  G  W K +K   +P ++K  +H  +++      I+  E++  RV+ + + + +  
Sbjct: 801  PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860

Query: 1119 ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 1178
            + + L+N+N VLE+ S+MN S ++RL  T+ ++  + K ++++  +L  SE  +K     
Sbjct: 861  VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918

Query: 1179 LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 1235
            L++ +PPCVP+ G+YLT++   EEG P   +     L+NFSK R ++ I  EI+Q+Q   
Sbjct: 919  LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978

Query: 1236 YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 1272
            Y +  ++ + ++   L      M++E    L+  SL IEP+ P
Sbjct: 979  YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021



 Score = 34.3 bits (77), Expect = 0.78
 Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 34/219 (15%)

Query: 489 ERQCFLFSKHLIICTRGSGGKLHL--TKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHL 546
           ER  FLF   L+IC + + G+  L    N    L +   + + +  +++        D  
Sbjct: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKD--------DTN 508

Query: 547 DFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQ 606
           ++K   E       +VI  A S +EK  W                M        + T+ +
Sbjct: 509 EYKHAFEIILKDENSVIFSAKSAEEKNNW----------------MAALISLQYRSTLER 552

Query: 607 MIKRTR-EGTREAEMSRSDASLYC-----DDVDIRFSKTMN-SCKVLQIRYASVERLLER 659
           M+  T  +  +E +M    A +Y       + +I F + M     +  I+  +V +L+ER
Sbjct: 553 MLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIER 612

Query: 660 LTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698
           LT   +   +F+ TFL +YR F     +L  +I  ++ P
Sbjct: 613 LTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP 651


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score =  142 bits (357), Expect = 3e-33
 Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)

Query: 1026 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1083
            A GV A P   H   + EIAEQLTLLD  +F KI   E     W K +  E++P + + T
Sbjct: 844  ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901

Query: 1084 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1143
            +HFN++S  + S I+  E    R   + K++ +    R L+N+N+ L I S+++ + I R
Sbjct: 902  EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961

Query: 1144 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1203
            L+  W    KQT   + +   L+ S   F+  R AL   +PPC+PYLG+ L DL F+  G
Sbjct: 962  LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016

Query: 1204 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1263
             P+Y  DG VNFSK     +I+  +R FQQ  Y +     +  +  D S  + EE+L+E 
Sbjct: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075

Query: 1264 SLRIEPK 1270
            SL+I+P+
Sbjct: 1076 SLKIKPR 1082


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score =  142 bits (357), Expect = 3e-33
 Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)

Query: 1026 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1083
            A GV A P   H   + EIAEQLTLLD  +F KI   E     W K +  E++P + + T
Sbjct: 826  ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 883

Query: 1084 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1143
            +HFN++S  + S I+  E    R   + K++ +    R L+N+N+ L I S+++ + I R
Sbjct: 884  EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 943

Query: 1144 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1203
            L+  W    KQT   + +   L+ S   F+  R AL   +PPC+PYLG+ L DL F+  G
Sbjct: 944  LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 998

Query: 1204 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1263
             P+Y  DG VNFSK     +I+  +R FQQ  Y +     +  +  D S  + EE+L+E 
Sbjct: 999  NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1057

Query: 1264 SLRIEPK 1270
            SL+I+P+
Sbjct: 1058 SLKIKPR 1064


>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
            [Homo sapiens]
          Length = 803

 Score =  139 bits (350), Expect = 2e-32
 Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)

Query: 921  EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 978
            ++Y  ++  +      Q + + + VIR    N + ++LR W+ + ++DF       C  K
Sbjct: 150  DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205

Query: 979  VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 1029
            ++ +L  +M   DPE      + A N++    +++       P     +LEE  ++  G 
Sbjct: 206  LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259

Query: 1030 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 1086
             AE F   S   +AEQLT +D  +FKK+      G  W + +K E     P I  T   F
Sbjct: 260  SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318

Query: 1087 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144
            N ++  + S I+  +++    R   IEKW+ +A  CR L N++++  I S++  ++I+RL
Sbjct: 319  NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378

Query: 1145 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 1186
            KKTW  V +    + ++L             ++L+  EG  +F NL  ++K         
Sbjct: 379  KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438

Query: 1187 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1233
                         VPYLG +LTDL  ++    +Y E GL+NF K R    +I +I+  Q 
Sbjct: 439  LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498

Query: 1234 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 1268
               +Y +    K  Q+   Q  + +EES Y  S  IE
Sbjct: 499  ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
            sapiens]
          Length = 583

 Score =  131 bits (330), Expect = 4e-30
 Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)

Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
            E A Q+TL+D  VFK I  +E    GW K EK    P  +  T+ FN +S  +  EI+  
Sbjct: 52   EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111

Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
            + +  R   +  ++  A     L+N +A++ + S +  + IFRL KTW  +S++ K   +
Sbjct: 112  QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171

Query: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
            KL+ ++S E  +K LR+ + +    PC+PYLG+YL+DL +I+   P+ T   L N  +  
Sbjct: 172  KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230

Query: 1220 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 1273
            ++++I+R I   QQ+  Y I     V +YL    ++ +     E+  Y+ SL+IEP   T
Sbjct: 231  LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290


>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
            sapiens]
          Length = 557

 Score =  123 bits (308), Expect = 1e-27
 Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)

Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
            E A Q+TL+D  VFK I  EE    GW K EK+   P ++  T+ FN +S  +  EI+  
Sbjct: 53   EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112

Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
            + +  R   +  +V +A     L+N ++++ + S++  + IFRL KTW  ++++ K   +
Sbjct: 113  QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172

Query: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
            KL  L+S E  +K  RE +++    P +PYLG+YL DL +I+   P  +   + N  +  
Sbjct: 173  KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231

Query: 1220 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 1269
             +++I+R I   Q         T   ++   K  +Y+ + Q FV D+   Y+ SLRIEP
Sbjct: 232  QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288


>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
            isoform 1 [Homo sapiens]
          Length = 716

 Score =  115 bits (288), Expect = 3e-25
 Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)

Query: 954  VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994
            V++VL  W+  H QDF     + +L                  K    LE+ + + E   
Sbjct: 144  VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203

Query: 995  QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051
            +E   +      R     DP  ++   EE    M +G +   F   S  E+AEQLTL+D 
Sbjct: 204  EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260

Query: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106
             +F K+   E  G  W + ++      +P +  T   FN ++  +   ++    + A  R
Sbjct: 261  ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320

Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
               +EKW+ +A  CR L N++++  I S++  + I+RLK++W  VS++  +   KL ++ 
Sbjct: 321  AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380

Query: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206
            S E    + RE L                        P  VPYLG +LTDL  ++   P+
Sbjct: 381  SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440

Query: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
              E  L+NF K R    I+  I+Q Q+   +Y +     +   L  Q+ + +E+S Y  S
Sbjct: 441  MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499

Query: 1265 LRIEP 1269
              IEP
Sbjct: 500  RVIEP 504


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
            isoform 2 [Homo sapiens]
          Length = 710

 Score =  115 bits (288), Expect = 3e-25
 Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)

Query: 954  VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994
            V++VL  W+  H QDF     + +L                  K    LE+ + + E   
Sbjct: 144  VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203

Query: 995  QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051
            +E   +      R     DP  ++   EE    M +G +   F   S  E+AEQLTL+D 
Sbjct: 204  EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260

Query: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106
             +F K+   E  G  W + ++      +P +  T   FN ++  +   ++    + A  R
Sbjct: 261  ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320

Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
               +EKW+ +A  CR L N++++  I S++  + I+RLK++W  VS++  +   KL ++ 
Sbjct: 321  AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380

Query: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206
            S E    + RE L                        P  VPYLG +LTDL  ++   P+
Sbjct: 381  SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440

Query: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
              E  L+NF K R    I+  I+Q Q+   +Y +     +   L  Q+ + +E+S Y  S
Sbjct: 441  MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499

Query: 1265 LRIEP 1269
              IEP
Sbjct: 500  RVIEP 504


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score =  114 bits (286), Expect = 5e-25
 Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
            ++   +R+W+ K   +F     L   +I   EE       L  E+  +   I ++   D 
Sbjct: 73   KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128

Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
                   +++++  +G     F++   +E+AE LT L+H  F++I + ++  Q ++    
Sbjct: 129  MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184

Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
             E  P + ++   FN IS  +   ++       R   I K++ VA     L N+N ++ +
Sbjct: 185  LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244

Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
               ++ S+I RLK+T   +S +     +++ +LVSS G + N R+A  +CD   +P LG+
Sbjct: 245  VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304

Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
            +L DL  +    P++TE+  VN  KM  +S  + E+   Q  ++ +E    +   L L  
Sbjct: 305  HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364

Query: 1252 SFVMDEESLYESSLRIEPK 1270
                 E+ +Y+ SL +EP+
Sbjct: 365  DLYHTEDDIYKLSLVLEPR 383


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
            DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score =  114 bits (286), Expect = 5e-25
 Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
            ++   +R+W+ K   +F     L   +I   EE       L  E+  +   I ++   D 
Sbjct: 73   KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128

Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
                   +++++  +G     F++   +E+AE LT L+H  F++I + ++  Q ++    
Sbjct: 129  MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184

Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
             E  P + ++   FN IS  +   ++       R   I K++ VA     L N+N ++ +
Sbjct: 185  LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244

Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
               ++ S+I RLK+T   +S +     +++ +LVSS G + N R+A  +CD   +P LG+
Sbjct: 245  VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304

Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
            +L DL  +    P++TE+  VN  KM  +S  + E+   Q  ++ +E    +   L L  
Sbjct: 305  HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364

Query: 1252 SFVMDEESLYESSLRIEPK 1270
                 E+ +Y+ SL +EP+
Sbjct: 365  DLYHTEDDIYKLSLVLEPR 383


>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
            isoform 2 [Homo sapiens]
          Length = 689

 Score =  114 bits (286), Expect = 5e-25
 Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
            ++   +R+W+ K   +F     L   +I   EE       L  E+  +   I ++   D 
Sbjct: 73   KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128

Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
                   +++++  +G     F++   +E+AE LT L+H  F++I + ++  Q ++    
Sbjct: 129  MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184

Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
             E  P + ++   FN IS  +   ++       R   I K++ VA     L N+N ++ +
Sbjct: 185  LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244

Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
               ++ S+I RLK+T   +S +     +++ +LVSS G + N R+A  +CD   +P LG+
Sbjct: 245  VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304

Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
            +L DL  +    P++TE+  VN  KM  +S  + E+   Q  ++ +E    +   L L  
Sbjct: 305  HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364

Query: 1252 SFVMDEESLYESSLRIEPK 1270
                 E+ +Y+ SL +EP+
Sbjct: 365  DLYHTEDDIYKLSLVLEPR 383


>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
            sapiens]
          Length = 730

 Score =  110 bits (276), Expect = 7e-24
 Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)

Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
            ++A +L   D  +F  I  +E     + +    E T  +    +  N++   +A+EI+  
Sbjct: 498  DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557

Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
              +  RV  ++K++ +A  C+   N N+   I   +N +++ RL +TW K+  + K L  
Sbjct: 558  SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617

Query: 1161 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1220
            +L+ L       K  R+A K   PP +P++ + L D+ FI EG   +  D LVNF K+ M
Sbjct: 618  ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676

Query: 1221 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1271
            I+  +R +R     QF   + K EHQ ++  Y+     +  +++L+E S RIEP++
Sbjct: 677  IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730


>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
            [Homo sapiens]
          Length = 914

 Score =  105 bits (263), Expect = 2e-22
 Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)

Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1098
            +AEQ TL+D  +FKK+      G  W + +K  +    P I  T   FN ++N + +  +
Sbjct: 390  VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 449

Query: 1099 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
             N    A  R   +E W+ VA  CR L N++++  I S++  ++I RLKKTW  VS+ + 
Sbjct: 450  GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 509

Query: 1157 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1192
             +  KL ++ S E  +   RE L             +P                VPYLG 
Sbjct: 510  RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 569

Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1250
            +LTDL  ++    +Y    L+NF K R    +I +I+  Q     Y I    +   +   
Sbjct: 570  FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 629

Query: 1251 QSFVMDEESLYESSLRIEP 1269
               + + ES Y  S  +EP
Sbjct: 630  VERLSETES-YNLSCELEP 647



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 642 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695
           +CKV  ++  ++E+L+E L    +   + ++  FL +YR FTT   VLD L   Y
Sbjct: 110 TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 164


>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
            [Homo sapiens]
          Length = 859

 Score =  105 bits (263), Expect = 2e-22
 Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)

Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1098
            +AEQ TL+D  +FKK+      G  W + +K  +    P I  T   FN ++N + +  +
Sbjct: 335  VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394

Query: 1099 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
             N    A  R   +E W+ VA  CR L N++++  I S++  ++I RLKKTW  VS+ + 
Sbjct: 395  GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454

Query: 1157 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1192
             +  KL ++ S E  +   RE L             +P                VPYLG 
Sbjct: 455  RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514

Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1250
            +LTDL  ++    +Y    L+NF K R    +I +I+  Q     Y I    +   +   
Sbjct: 515  FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574

Query: 1251 QSFVMDEESLYESSLRIEP 1269
               + + ES Y  S  +EP
Sbjct: 575  VERLSETES-YNLSCELEP 592



 Score = 35.4 bits (80), Expect = 0.35
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 642 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695
           +CKV  ++  ++E+L+E L    +   + ++  FL +YR FTT   VLD L   Y
Sbjct: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109


>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
            [Homo sapiens]
          Length = 867

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)

Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
            FE  S+ ++A Q+T+ D  +F  +   E     + +    + T  +    + FN+I   +
Sbjct: 624  FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683

Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
             +EI     ++ RV  ++K++ +A  C+   N N+   I   ++  A+ RL  TW K+  
Sbjct: 684  VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743

Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
            + K    + + L+      +  R  +   +PP +P++ + + D+ F  EG   +  D LV
Sbjct: 744  KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802

Query: 1214 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1267
            NF KMRMI++  R +R ++        A   ++   V  Y+   + + ++ +L + S R+
Sbjct: 803  NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862

Query: 1268 EPKLP 1272
            EP+ P
Sbjct: 863  EPRRP 867


>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
            [Homo sapiens]
          Length = 1011

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)

Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
            FE  S+ ++A Q+T+ D  +F  +   E     + +    + T  +    + FN+I   +
Sbjct: 768  FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827

Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
             +EI     ++ RV  ++K++ +A  C+   N N+   I   ++  A+ RL  TW K+  
Sbjct: 828  VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887

Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
            + K    + + L+      +  R  +   +PP +P++ + + D+ F  EG   +  D LV
Sbjct: 888  KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946

Query: 1214 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1267
            NF KMRMI++  R +R ++        A   ++   V  Y+   + + ++ +L + S R+
Sbjct: 947  NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 1006

Query: 1268 EPKLP 1272
            EP+ P
Sbjct: 1007 EPRRP 1011


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
          Length = 762

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)

Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
            F++    E++E LT L+   F++I + ++  Q ++     +  P + ++    N IS  +
Sbjct: 201  FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258

Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
               ++       R     K++ VA     L N+N ++ +   +  S+I RLK+T   V  
Sbjct: 259  QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318

Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
            +   ++ ++ +L+SS   + N R A   C    +P LG++L DL  + E  P+Y EDG V
Sbjct: 319  EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378

Query: 1214 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1270
            N  K+  + + I E+ Q Q+ A  +E    +   L L       E+ +YE S   EP+
Sbjct: 379  NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
          Length = 797

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)

Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
            F++    E++E LT L+   F++I + ++  Q ++     +  P + ++    N IS  +
Sbjct: 201  FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258

Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
               ++       R     K++ VA     L N+N ++ +   +  S+I RLK+T   V  
Sbjct: 259  QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318

Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
            +   ++ ++ +L+SS   + N R A   C    +P LG++L DL  + E  P+Y EDG V
Sbjct: 319  EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378

Query: 1214 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1270
            N  K+  + + I E+ Q Q+ A  +E    +   L L       E+ +YE S   EP+
Sbjct: 379  NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436


>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
           [Homo sapiens]
          Length = 904

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 69/273 (25%), Positives = 135/273 (49%), Gaps = 7/273 (2%)

Query: 236 DSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSET 295
           DS  KR +VV  +L++E +YVQ L I+ + ++ PL+ A SS +  ++  ++  IF +   
Sbjct: 562 DSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQ 621

Query: 296 IMFLHQIFYQGLKARISSW-PTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQN- 353
           I+ L++ F   L+ R+  W P   + ++       LN Y  F  N+   L+ +  C++  
Sbjct: 622 ILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMI 681

Query: 354 RDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413
             F   LK ++     +  +L   L YP  +   Y+  L+ +  HTP EHV+R  L  A 
Sbjct: 682 PAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAI 741

Query: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGK 473
            ++++    + D++ +   ++ +L+  + II GC  L + ++  +R   + Q+   ++  
Sbjct: 742 DQIKKYKGYI-DQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800

Query: 474 ITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506
               RL     +   +   FLF+  L++ +RG+
Sbjct: 801 SFSLRL----YEHIHDLSLFLFNDALLVSSRGT 829


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
            +  +++R+W+S    +F+ N EL        E++     LL QE  R+ ++ I       
Sbjct: 74   KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126

Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
                 Q+T        +   +  F++   +E+AE LT L++  F KI ++++    ++  
Sbjct: 127  YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184

Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
                  P + +    FN +S  +   I+       R   I  +V VA+    L N+N ++
Sbjct: 185  GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244

Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
             +   ++ S+I RLK+T   VS +T  L + L +LV++ G + N R  L  C     P L
Sbjct: 245  AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304

Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
            G++L DL  ++   P++ +     +N +KM+ +  I+ E+         ++    +   L
Sbjct: 305  GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364

Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
               LDQ     E+ LY+ SL+ EP+
Sbjct: 365  TVSLDQ--YQTEDELYQLSLQREPR 387


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
            +  +++R+W+S    +F+ N EL        E++     LL QE  R+ ++ I       
Sbjct: 74   KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126

Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
                 Q+T        +   +  F++   +E+AE LT L++  F KI ++++    ++  
Sbjct: 127  YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184

Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
                  P + +    FN +S  +   I+       R   I  +V VA+    L N+N ++
Sbjct: 185  GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244

Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
             +   ++ S+I RLK+T   VS +T  L + L +LV++ G + N R  L  C     P L
Sbjct: 245  AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304

Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
            G++L DL  ++   P++ +     +N +KM+ +  I+ E+         ++    +   L
Sbjct: 305  GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364

Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
               LDQ     E+ LY+ SL+ EP+
Sbjct: 365  TVSLDQ--YQTEDELYQLSLQREPR 387


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)

Query: 953  RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
            +  +++R+W+S    +F+ N EL        E++     LL QE  R+ ++ I       
Sbjct: 74   KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126

Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
                 Q+T        +   +  F++   +E+AE LT L++  F KI ++++    ++  
Sbjct: 127  YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184

Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
                  P + +    FN +S  +   I+       R   I  +V VA+    L N+N ++
Sbjct: 185  GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244

Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
             +   ++ S+I RLK+T   VS +T  L + L +LV++ G + N R  L  C     P L
Sbjct: 245  AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304

Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
            G++L DL  ++   P++ +     +N +KM+ +  I+ E+         ++    +   L
Sbjct: 305  GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364

Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
               LDQ     E+ LY+ SL+ EP+
Sbjct: 365  TVSLDQ--YQTEDELYQLSLQREPR 387


>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
          Length = 473

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)

Query: 1042 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 1089
            +A+QLT   H+  +++ Y   E F Q +++ +   N+++ Y   K T++       FN +
Sbjct: 209  LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265

Query: 1090 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 1149
            S L+A+EI        R   IE ++ VA  C  + N+N+++ I S MN S + RLKKTW 
Sbjct: 266  SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325

Query: 1150 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 1198
            KV     A  D L+  +     F N R AL+             +   +P+  + + D+ 
Sbjct: 326  KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382

Query: 1199 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 1258
            F+ EG  N   +G VNF K   ++  + E   ++Q     E   K+ QYLL    V  E+
Sbjct: 383  FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441

Query: 1259 SLYESSLRIE 1268
            +LY +S   E
Sbjct: 442  ALYLASYESE 451


>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
            [Homo sapiens]
          Length = 473

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)

Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 1098
            +AEQLTL+D  +FKK+   E  G  W +  L+ NE   P +  T  HFN ++N I +  +
Sbjct: 223  LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282

Query: 1099 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
             +  + AR  A  +E W+ VA  C  L+N+++V  I S++  + I +L KTW  VS ++ 
Sbjct: 283  GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342

Query: 1157 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 1199
              + +L K        L+   G FK          ++  L+      VP+LG +LT+L  
Sbjct: 343  KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402

Query: 1200 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 1257
            ++   P+  +    N +K      +++E++  Q  A  Y++    K   Y      + D+
Sbjct: 403  LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459

Query: 1258 ESLYESSLRIEPKLP 1272
            ES Y+ S ++EP+ P
Sbjct: 460  ES-YKLSCQLEPENP 473


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)

Query: 1038 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 1097
            S +E+A QL++ +  +F+ I   E+      KL        + +  +  N  +  +ASEI
Sbjct: 717  STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775

Query: 1098 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 1157
            +R  +   R+  I+ ++ +A  CR   N+N++  I S +N + + RL+ TW K+  + + 
Sbjct: 776  LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835

Query: 1158 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 1215
            L   LQ L          R  L  +N  PP +P   +   DL F+ EG  +   DGLVNF
Sbjct: 836  LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894

Query: 1216 SKMRMISHIIREI 1228
             K+RMI+  IR +
Sbjct: 895  EKLRMIAKEIRHV 907


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,303,600
Number of Sequences: 37866
Number of extensions: 2059042
Number of successful extensions: 9420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 8691
Number of HSP's gapped (non-prelim): 858
length of query: 1273
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1159
effective length of database: 13,930,794
effective search space: 16145790246
effective search space used: 16145790246
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press