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Search of human proteins with 24797099
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24797099 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 1 [Homo sapiens]
(1273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 2526 0.0
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 2479 0.0
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 1634 0.0
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 972 0.0
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 152 3e-36
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 151 3e-36
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 142 3e-33
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 142 3e-33
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 139 2e-32
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 131 4e-30
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 123 1e-27
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 115 3e-25
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 115 3e-25
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 114 5e-25
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 114 5e-25
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 114 5e-25
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 110 7e-24
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 105 2e-22
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 105 2e-22
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 100 2e-20
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 100 2e-20
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 98 4e-20
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 98 4e-20
gi|118150678 epithelial cell transforming sequence 2 oncogene-li... 96 2e-19
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 96 3e-19
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 96 3e-19
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 96 3e-19
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 92 2e-18
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 92 2e-18
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 92 4e-18
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 2526 bits (6547), Expect = 0.0
Identities = 1273/1273 (100%), Positives = 1273/1273 (100%)
Query: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
Sbjct: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
Query: 61 RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
Sbjct: 61 RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
Query: 121 VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
Sbjct: 121 VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
Query: 181 LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
Sbjct: 181 LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
Query: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
Query: 301 QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
Sbjct: 301 QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
Query: 361 KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS
Sbjct: 361 KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
Query: 421 RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
Sbjct: 421 RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
Query: 481 SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
Sbjct: 481 SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
Query: 541 QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
Sbjct: 541 QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
Query: 601 KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660
KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
Sbjct: 601 KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660
Query: 661 TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN
Sbjct: 661 TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720
Query: 721 KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780
KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN
Sbjct: 721 KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780
Query: 781 GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840
GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE
Sbjct: 781 GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840
Query: 841 ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900
ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL
Sbjct: 841 ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900
Query: 901 SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960
SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH
Sbjct: 901 SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960
Query: 961 WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020
WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE
Sbjct: 961 WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020
Query: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080
EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM
Sbjct: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080
Query: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140
KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA
Sbjct: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140
Query: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200
IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI
Sbjct: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200
Query: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260
EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL
Sbjct: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260
Query: 1261 YESSLRIEPKLPT 1273
YESSLRIEPKLPT
Sbjct: 1261 YESSLRIEPKLPT 1273
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 2479 bits (6425), Expect = 0.0
Identities = 1257/1273 (98%), Positives = 1257/1273 (98%), Gaps = 16/1273 (1%)
Query: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
Sbjct: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
Query: 61 RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
Sbjct: 61 RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW 120
Query: 121 VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
Sbjct: 121 VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS 180
Query: 181 LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
Sbjct: 181 LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK 240
Query: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH 300
Query: 301 QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
Sbjct: 301 QIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL 360
Query: 361 KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS
Sbjct: 361 KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELS 420
Query: 421 RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
Sbjct: 421 RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG 480
Query: 481 SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
Sbjct: 481 SLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG 540
Query: 541 QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
Sbjct: 541 QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS 600
Query: 601 KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 660
KVTVPQMIK SDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
Sbjct: 601 KVTVPQMIK-------------SDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL 647
Query: 661 TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN 720
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPA RSLELLFASGQNN
Sbjct: 648 TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPA---RSLELLFASGQNN 704
Query: 721 KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 780
KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN
Sbjct: 705 KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSN 764
Query: 781 GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 840
GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE
Sbjct: 765 GYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE 824
Query: 841 ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 900
ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL
Sbjct: 825 ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSAL 884
Query: 901 SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 960
SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH
Sbjct: 885 SAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRH 944
Query: 961 WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1020
WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE
Sbjct: 945 WVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE 1004
Query: 1021 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1080
EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM
Sbjct: 1005 EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIM 1064
Query: 1081 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1140
KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA
Sbjct: 1065 KTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSA 1124
Query: 1141 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1200
IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI
Sbjct: 1125 IFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI 1184
Query: 1201 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1260
EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL
Sbjct: 1185 EEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESL 1244
Query: 1261 YESSLRIEPKLPT 1273
YESSLRIEPKLPT
Sbjct: 1245 YESSLRIEPKLPT 1257
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 1634 bits (4232), Expect = 0.0
Identities = 839/1286 (65%), Positives = 1009/1286 (78%), Gaps = 64/1286 (4%)
Query: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
MQK +R N+GH L LARK+GT++G+LSK++++ ++W KWFAL QN+LFYFE + S
Sbjct: 1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60
Query: 61 RPSGLYLLEGCVCDRAPSPKPALSA----KEPLEKQHYFTVNFSHENQKALELRTEDAKD 116
RP+G+YLLEGC C+R P+P A + ++ L+KQ+YFTV F HE QK LELR E+ +D
Sbjct: 61 RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120
Query: 117 CDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKA 176
EW+ AI ASY + E E LMQKY+HL+QIVETEK A QLR Q+ED + EIERLK+
Sbjct: 121 GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180
Query: 177 EITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHAD 236
EI +L K ER++ Q+ DED DIKKIKKVQSF+RGWLCRRKWKTI+QDYI SPHA+
Sbjct: 181 EIIALNKTKERMRPYQS-NQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAE 239
Query: 237 SMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETI 296
SMRKRNQ+VF+M+EAE+EYV QL+ILVN FLRPLRMAASSKKPPI+HDDVSSIFLNSETI
Sbjct: 240 SMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETI 299
Query: 297 MFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDF 356
MFLH+IF+QGLKARI++WPTL+LADLFDILLPMLNIYQEFVRNHQYSLQ+LA+CKQNRDF
Sbjct: 300 MFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDF 359
Query: 357 DKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKL 416
DKLLK YEA P CE R LETFLTYPMFQIPRYI+TLHELLAHTPHEHVER SL++AKSKL
Sbjct: 360 DKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKL 419
Query: 417 EELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITR 476
EELSR+MHDEVS+TENIRKNLAIERMI+EGC+ILLDTSQTF+RQGSLIQVP E+GK+++
Sbjct: 420 EELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSK 479
Query: 477 GRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTK-NGVISLIDCTLLEEPESTEEE 535
RLGSLSLKKEGERQCFLF+KH +ICTR SGGKLHL K GV+SLIDCTL+EEP++++++
Sbjct: 480 VRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDD 539
Query: 536 AKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNA 595
+KGSGQ HLDFKI VEP D+ FTV+L+A SRQEKAAW SDISQCVDNIRCNGLM
Sbjct: 540 SKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIV 599
Query: 596 FEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVER 655
FEENSKVTVP MIK SDA L+ DD DI FSKT+NSCKV QIRYASVER
Sbjct: 600 FEENSKVTVPHMIK-------------SDARLHKDDTDICFSKTLNSCKVPQIRYASVER 646
Query: 656 LLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFA 715
LLERLTDLRFLSIDFLNTFLH+YR+FTTA VVL KL IYK+P ++IP +RSLEL FA
Sbjct: 647 LLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIP---VRSLELFFA 703
Query: 716 SGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAAL 775
+ QNN+ + KSPR RKFSSPPPL++++TSSP R RKLSL P+ + ALDL
Sbjct: 704 TSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTS 763
Query: 776 SCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALS----- 830
S + + SP + T ++ + S P++ T E+ D +
Sbjct: 764 SSPTT------TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKL 817
Query: 831 KQSSEVSMREESDIDQ---NQSDDGD-TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVV 886
K+S + ++ E + D+ S D TE SP +SP+TP+ ++ +
Sbjct: 818 KRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGG----------- 866
Query: 887 MTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVI 946
+ DN ++S ASAFAIATA A G+P GF +R DKEF+I
Sbjct: 867 ----QTADNAHCSVSPASAFAIATAAAGHGSP------------PGFNNTERTCDKEFII 910
Query: 947 RRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRT 1006
RR ATNRVLNVLRHWVSKH+QDFE N+ELK V+ LEEV+ DP+LL QERKAAANI+R
Sbjct: 911 RRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRA 970
Query: 1007 LTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQG 1066
L+Q+D D + LE+I QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQG
Sbjct: 971 LSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQG 1030
Query: 1067 WMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNY 1126
WMKL+KNERTPYIMKT++HFND+SNL+AS+I+ D+++R +AIEKWVAVADICRCLHNY
Sbjct: 1031 WMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNY 1090
Query: 1127 NAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPC 1186
N VLEITS++NRSAI+RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP
Sbjct: 1091 NGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPA 1150
Query: 1187 VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQ 1246
VPYLGMYLTDLAFIEEGTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV Q
Sbjct: 1151 VPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQ 1210
Query: 1247 YLLDQSFVMDEESLYESSLRIEPKLP 1272
YLLD+ ++DE++LYE SL+IEP+LP
Sbjct: 1211 YLLDKDLIIDEDTLYELSLKIEPRLP 1236
>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 2 [Homo sapiens]
Length = 489
Score = 973 bits (2514), Expect = 0.0
Identities = 489/489 (100%), Positives = 489/489 (100%)
Query: 785 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 844
MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI
Sbjct: 1 MYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDI 60
Query: 845 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 904
DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS
Sbjct: 61 DQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAAS 120
Query: 905 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 964
AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK
Sbjct: 121 AFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSK 180
Query: 965 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 1024
HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ
Sbjct: 181 HSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQ 240
Query: 1025 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 1084
MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK
Sbjct: 241 MAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTK 300
Query: 1085 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144
HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL
Sbjct: 301 HFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360
Query: 1145 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 1204
KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT
Sbjct: 361 KKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGT 420
Query: 1205 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS
Sbjct: 421 PNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESS 480
Query: 1265 LRIEPKLPT 1273
LRIEPKLPT
Sbjct: 481 LRIEPKLPT 489
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 152 bits (383), Expect = 3e-36
Identities = 104/353 (29%), Positives = 183/353 (51%), Gaps = 24/353 (6%)
Query: 936 DQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQ 995
D + KE+V + R+LNV RHWV H DFE + EL ++ F+ V + + +
Sbjct: 671 DLKRFRKEYV--QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRG--KAMKK 726
Query: 996 ERKAAANIIRTLTQEDPG--DNQITLEEITQMAEGVKAEP--FENHSAL-----EIAEQL 1046
++ A IIR Q + IT E E ++P FE + EIA QL
Sbjct: 727 WVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQL 786
Query: 1047 TLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINAR 1106
TLL+ +++K+ E G W K +K +P ++K +H +++ I+ E+ R
Sbjct: 787 TLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 846
Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
V+ + + + + + + L+N+N VLEI S++N +++RL T+ + ++ + ++D+ +L
Sbjct: 847 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL- 905
Query: 1167 SSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISH 1223
S+ FK LK+ +PPCVP+ G+YLT++ EEG ++ + L+NFSK R ++
Sbjct: 906 -SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAE 964
Query: 1224 IIREIRQFQQTAYKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPK 1270
I EI+Q+Q Y + + + ++ L ++E L+ SL IEP+
Sbjct: 965 ITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
Score = 33.5 bits (75), Expect = 1.3
Identities = 46/217 (21%), Positives = 88/217 (40%), Gaps = 30/217 (13%)
Query: 489 ERQCFLFSKHLIICTRGSGG-KLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLD 547
ER FLF +I C G +L + L + ++ + + ++E D +
Sbjct: 456 ERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKE--------DTCE 507
Query: 548 FKIGVEPKDSPPFTVILVASSRQEKAAWTSDI-----SQCVDNIRCNGLMMNAFEENSKV 602
K E ++I A S +EK W + + +D + + L+ E+ ++
Sbjct: 508 HKHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRL 567
Query: 603 TVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQI-RYASVERLLERLT 661
P++ + + + E +I F + S + I + +V +L+ERLT
Sbjct: 568 PSPEVYRFVVKDSEE---------------NIVFEDNLQSRSGIPIIKGGTVVKLIERLT 612
Query: 662 DLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698
+ +F+ TFL +YR F +L LI ++ P
Sbjct: 613 YHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIP 649
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 151 bits (382), Expect = 3e-36
Identities = 102/343 (29%), Positives = 175/343 (51%), Gaps = 32/343 (9%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDP-----ELLTQ--ERKAAANIIR 1005
RVLNV RHWV H DFE + L ++ F+ V E +T+ +RK A
Sbjct: 688 RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAR--- 744
Query: 1006 TLTQEDPGDNQITLEEITQMAEGVKAEPFENHS-------ALEIAEQLTLLDHLVFKKIP 1058
PG N IT + E + P + +EIA QLTLL+ +++ +
Sbjct: 745 ---DNGPGHN-ITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQ 800
Query: 1059 YEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVAD 1118
E G W K +K +P ++K +H +++ I+ E++ RV+ + + + +
Sbjct: 801 PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQ 860
Query: 1119 ICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREA 1178
+ + L+N+N VLE+ S+MN S ++RL T+ ++ + K ++++ +L SE +K
Sbjct: 861 VFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAK 918
Query: 1179 LKNCDPPCVPYLGMYLTDLAFIEEGTPNYTE---DGLVNFSKMRMISHIIREIRQFQQTA 1235
L++ +PPCVP+ G+YLT++ EEG P + L+NFSK R ++ I EI+Q+Q
Sbjct: 919 LRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP 978
Query: 1236 YKIEHQAKVTQY---LLDQSFVMDEE---SLYESSLRIEPKLP 1272
Y + ++ + ++ L M++E L+ SL IEP+ P
Sbjct: 979 YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021
Score = 34.3 bits (77), Expect = 0.78
Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 34/219 (15%)
Query: 489 ERQCFLFSKHLIICTRGSGGKLHL--TKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHL 546
ER FLF L+IC + + G+ L N L + + + + +++ D
Sbjct: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKD--------DTN 508
Query: 547 DFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQ 606
++K E +VI A S +EK W M + T+ +
Sbjct: 509 EYKHAFEIILKDENSVIFSAKSAEEKNNW----------------MAALISLQYRSTLER 552
Query: 607 MIKRTR-EGTREAEMSRSDASLYC-----DDVDIRFSKTMN-SCKVLQIRYASVERLLER 659
M+ T + +E +M A +Y + +I F + M + I+ +V +L+ER
Sbjct: 553 MLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIER 612
Query: 660 LTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKP 698
LT + +F+ TFL +YR F +L +I ++ P
Sbjct: 613 LTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP 651
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 142 bits (357), Expect = 3e-33
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 1026 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1083
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 844 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901
Query: 1084 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1143
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 902 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
Query: 1144 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1203
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 962 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016
Query: 1204 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1263
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075
Query: 1264 SLRIEPK 1270
SL+I+P+
Sbjct: 1076 SLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 142 bits (357), Expect = 3e-33
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 1026 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1083
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 826 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 883
Query: 1084 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1143
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 884 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 943
Query: 1144 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1203
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 944 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 998
Query: 1204 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1263
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 999 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1057
Query: 1264 SLRIEPK 1270
SL+I+P+
Sbjct: 1058 SLKIKPR 1064
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 139 bits (350), Expect = 2e-32
Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)
Query: 921 EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 978
++Y ++ + Q + + + VIR N + ++LR W+ + ++DF C K
Sbjct: 150 DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205
Query: 979 VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 1029
++ +L +M DPE + A N++ +++ P +LEE ++ G
Sbjct: 206 LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259
Query: 1030 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 1086
AE F S +AEQLT +D +FKK+ G W + +K E P I T F
Sbjct: 260 SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
Query: 1087 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144
N ++ + S I+ +++ R IEKW+ +A CR L N++++ I S++ ++I+RL
Sbjct: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
Query: 1145 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 1186
KKTW V + + ++L ++L+ EG +F NL ++K
Sbjct: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
Query: 1187 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1233
VPYLG +LTDL ++ +Y E GL+NF K R +I +I+ Q
Sbjct: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
Query: 1234 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 1268
+Y + K Q+ Q + +EES Y S IE
Sbjct: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 131 bits (330), Expect = 4e-30
Identities = 78/240 (32%), Positives = 129/240 (53%), Gaps = 8/240 (3%)
Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
E A Q+TL+D VFK I +E GW K EK P + T+ FN +S + EI+
Sbjct: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
+ + R + ++ A L+N +A++ + S + + IFRL KTW +S++ K +
Sbjct: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
Query: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
KL+ ++S E +K LR+ + + PC+PYLG+YL+DL +I+ P+ T L N +
Sbjct: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
Query: 1220 MISHIIREIRQFQQTA-YKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLPT 1273
++++I+R I QQ+ Y I V +YL ++ + E+ Y+ SL+IEP T
Sbjct: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTST 290
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 123 bits (308), Expect = 1e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)
Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
E A Q+TL+D VFK I EE GW K EK+ P ++ T+ FN +S + EI+
Sbjct: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
+ + R + +V +A L+N ++++ + S++ + IFRL KTW ++++ K +
Sbjct: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
Query: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
KL L+S E +K RE +++ P +PYLG+YL DL +I+ P + + N +
Sbjct: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
Query: 1220 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 1269
+++I+R I Q T ++ K +Y+ + Q FV D+ Y+ SLRIEP
Sbjct: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 115 bits (288), Expect = 3e-25
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 954 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
Query: 995 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
Query: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
Query: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
Query: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
Query: 1265 LRIEP 1269
IEP
Sbjct: 500 RVIEP 504
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 115 bits (288), Expect = 3e-25
Identities = 97/365 (26%), Positives = 160/365 (43%), Gaps = 53/365 (14%)
Query: 954 VLNVLRHWVSKHSQDFE---TNDELKC----------------KVIGFLEEVMHDPELLT 994
V++VL W+ H QDF + +L K LE+ + + E
Sbjct: 144 VVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLEEAEREQ 203
Query: 995 QER--KAAANIIRTLTQEDPGDNQITLEEITQ-MAEGVKAEPFENHSALEIAEQLTLLDH 1051
+E + R DP ++ EE M +G + F S E+AEQLTL+D
Sbjct: 204 EEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF---SVDEVAEQLTLIDL 260
Query: 1052 LVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEIIRNEDINA--R 1106
+F K+ E G W + ++ +P + T FN ++ + ++ + A R
Sbjct: 261 ELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQR 320
Query: 1107 VSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLV 1166
+EKW+ +A CR L N++++ I S++ + I+RLK++W VS++ + KL ++
Sbjct: 321 AQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIF 380
Query: 1167 SSEGRFKNLREAL--------------------KNCDPPCVPYLGMYLTDLAFIEEGTPN 1206
S E + RE L P VPYLG +LTDL ++ P+
Sbjct: 381 SDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPD 440
Query: 1207 YTEDGLVNFSKMRMISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESS 1264
E L+NF K R I+ I+Q Q+ +Y + + L Q+ + +E+S Y S
Sbjct: 441 MLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQS-YRLS 499
Query: 1265 LRIEP 1269
IEP
Sbjct: 500 RVIEP 504
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 114 bits (286), Expect = 5e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 1252 SFVMDEESLYESSLRIEPK 1270
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 114 bits (286), Expect = 5e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 1252 SFVMDEESLYESSLRIEPK 1270
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
isoform 2 [Homo sapiens]
Length = 689
Score = 114 bits (286), Expect = 5e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
Query: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
Query: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
Query: 1252 SFVMDEESLYESSLRIEPK 1270
E+ +Y+ SL +EP+
Sbjct: 365 DLYHTEDDIYKLSLVLEPR 383
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 110 bits (276), Expect = 7e-24
Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
++A +L D +F I +E + + E T + + N++ +A+EI+
Sbjct: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
Query: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
+ RV ++K++ +A C+ N N+ I +N +++ RL +TW K+ + K L
Sbjct: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
Query: 1161 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1220
+L+ L K R+A K PP +P++ + L D+ FI EG + D LVNF K+ M
Sbjct: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676
Query: 1221 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1271
I+ +R +R QF + K EHQ ++ Y+ + +++L+E S RIEP++
Sbjct: 677 IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
[Homo sapiens]
Length = 914
Score = 105 bits (263), Expect = 2e-22
Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)
Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1098
+AEQ TL+D +FKK+ G W + +K + P I T FN ++N + + +
Sbjct: 390 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 449
Query: 1099 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
N A R +E W+ VA CR L N++++ I S++ ++I RLKKTW VS+ +
Sbjct: 450 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 509
Query: 1157 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1192
+ KL ++ S E + RE L +P VPYLG
Sbjct: 510 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 569
Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1250
+LTDL ++ +Y L+NF K R +I +I+ Q Y I + +
Sbjct: 570 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 629
Query: 1251 QSFVMDEESLYESSLRIEP 1269
+ + ES Y S +EP
Sbjct: 630 VERLSETES-YNLSCELEP 647
Score = 35.4 bits (80), Expect = 0.35
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)
Query: 642 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695
+CKV ++ ++E+L+E L + + ++ FL +YR FTT VLD L Y
Sbjct: 110 TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 164
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
[Homo sapiens]
Length = 859
Score = 105 bits (263), Expect = 2e-22
Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)
Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1098
+AEQ TL+D +FKK+ G W + +K + P I T FN ++N + + +
Sbjct: 335 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
Query: 1099 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
N A R +E W+ VA CR L N++++ I S++ ++I RLKKTW VS+ +
Sbjct: 395 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
Query: 1157 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1192
+ KL ++ S E + RE L +P VPYLG
Sbjct: 455 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
Query: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1250
+LTDL ++ +Y L+NF K R +I +I+ Q Y I + +
Sbjct: 515 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
Query: 1251 QSFVMDEESLYESSLRIEP 1269
+ + ES Y S +EP
Sbjct: 575 VERLSETES-YNLSCELEP 592
Score = 35.4 bits (80), Expect = 0.35
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)
Query: 642 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695
+CKV ++ ++E+L+E L + + ++ FL +YR FTT VLD L Y
Sbjct: 55 TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
[Homo sapiens]
Length = 867
Score = 99.8 bits (247), Expect = 2e-20
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
Query: 1214 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1267
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
Query: 1268 EPKLP 1272
EP+ P
Sbjct: 863 EPRRP 867
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 99.8 bits (247), Expect = 2e-20
Identities = 60/245 (24%), Positives = 118/245 (48%), Gaps = 7/245 (2%)
Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
FE S+ ++A Q+T+ D +F + E + + + T + + FN+I +
Sbjct: 768 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827
Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
+EI ++ RV ++K++ +A C+ N N+ I ++ A+ RL TW K+
Sbjct: 828 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887
Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
+ K + + L+ + R + +PP +P++ + + D+ F EG + D LV
Sbjct: 888 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946
Query: 1214 NFSKMRMISHIIREIRQFQ------QTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRI 1267
NF KMRMI++ R +R ++ A ++ V Y+ + + ++ +L + S R+
Sbjct: 947 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 1006
Query: 1268 EPKLP 1272
EP+ P
Sbjct: 1007 EPRRP 1011
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
Length = 762
Score = 98.2 bits (243), Expect = 4e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 1214 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1270
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
Length = 797
Score = 98.2 bits (243), Expect = 4e-20
Identities = 63/238 (26%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 1034 FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLI 1093
F++ E++E LT L+ F++I + ++ Q ++ + P + ++ N IS +
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
++ R K++ VA L N+N ++ + + S+I RLK+T V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 1154 QTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLV 1213
+ ++ ++ +L+SS + N R A C +P LG++L DL + E P+Y EDG V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 1214 NFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPK 1270
N K+ + + I E+ Q Q+ A +E + L L E+ +YE S EP+
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
[Homo sapiens]
Length = 904
Score = 95.9 bits (237), Expect = 2e-19
Identities = 69/273 (25%), Positives = 135/273 (49%), Gaps = 7/273 (2%)
Query: 236 DSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSET 295
DS KR +VV +L++E +YVQ L I+ + ++ PL+ A SS + ++ ++ IF +
Sbjct: 562 DSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQ 621
Query: 296 IMFLHQIFYQGLKARISSW-PTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQN- 353
I+ L++ F L+ R+ W P + ++ LN Y F N+ L+ + C++
Sbjct: 622 ILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMI 681
Query: 354 RDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413
F LK ++ + +L L YP + Y+ L+ + HTP EHV+R L A
Sbjct: 682 PAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAI 741
Query: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGK 473
++++ + D++ + ++ +L+ + II GC L + ++ +R + Q+ ++
Sbjct: 742 DQIKKYKGYI-DQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
Query: 474 ITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506
RL + + FLF+ L++ +RG+
Sbjct: 801 SFSLRL----YEHIHDLSLFLFNDALLVSSRGT 829
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 3e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 3e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 95.5 bits (236), Expect = 3e-19
Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 18/325 (5%)
Query: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQE--RKAAANIIRTLTQE 1010
+ +++R+W+S +F+ N EL E++ LL QE R+ ++ I
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHSSLIDIDSVPT 126
Query: 1011 DPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKL 1070
Q+T + + F++ +E+AE LT L++ F KI ++++ ++
Sbjct: 127 YKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSFVTH 184
Query: 1071 EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVL 1130
P + + FN +S + I+ R I +V VA+ L N+N ++
Sbjct: 185 GCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLM 244
Query: 1131 EITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYL 1190
+ ++ S+I RLK+T VS +T L + L +LV++ G + N R L C P L
Sbjct: 245 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPIL 304
Query: 1191 GMYLTDLAFIEEGTPNYTEDG--LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
G++L DL ++ P++ + +N +KM+ + I+ E+ ++ + L
Sbjct: 305 GVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLL 364
Query: 1249 ---LDQSFVMDEESLYESSLRIEPK 1270
LDQ E+ LY+ SL+ EP+
Sbjct: 365 TVSLDQ--YQTEDELYQLSLQREPR 387
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)
Query: 1042 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 1089
+A+QLT H+ +++ Y E F Q +++ + N+++ Y K T++ FN +
Sbjct: 209 LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265
Query: 1090 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 1149
S L+A+EI R IE ++ VA C + N+N+++ I S MN S + RLKKTW
Sbjct: 266 SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325
Query: 1150 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 1198
KV A D L+ + F N R AL+ + +P+ + + D+
Sbjct: 326 KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382
Query: 1199 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 1258
F+ EG N +G VNF K ++ + E ++Q E K+ QYLL V E+
Sbjct: 383 FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441
Query: 1259 SLYESSLRIE 1268
+LY +S E
Sbjct: 442 ALYLASYESE 451
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 92.4 bits (228), Expect = 2e-18
Identities = 74/255 (29%), Positives = 126/255 (49%), Gaps = 28/255 (10%)
Query: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMK--LEKNER-TPYIMKTTKHFNDISNLIASEII 1098
+AEQLTL+D +FKK+ E G W + L+ NE P + T HFN ++N I + +
Sbjct: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
Query: 1099 RNEDINARVSA--IEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156
+ + AR A +E W+ VA C L+N+++V I S++ + I +L KTW VS ++
Sbjct: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
Query: 1157 ALIDKLQK--------LVSSEGRFK---------NLREALKNCDPPCVPYLGMYLTDLAF 1199
+ +L K L+ G FK ++ L+ VP+LG +LT+L
Sbjct: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
Query: 1200 IEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLDQSFVMDE 1257
++ P+ + N +K +++E++ Q A Y++ K Y + D+
Sbjct: 403 LDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDK 459
Query: 1258 ESLYESSLRIEPKLP 1272
ES Y+ S ++EP+ P
Sbjct: 460 ES-YKLSCQLEPENP 473
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 4/193 (2%)
Query: 1038 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEI 1097
S +E+A QL++ + +F+ I E+ KL + + + N + +ASEI
Sbjct: 717 STVEVATQLSMRNFELFRNIEPTEYIDD-LFKLRSKTSCANLKRFEEVINQETFWVASEI 775
Query: 1098 IRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKA 1157
+R + R+ I+ ++ +A CR N+N++ I S +N + + RL+ TW K+ + +
Sbjct: 776 LRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEK 835
Query: 1158 LIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNF 1215
L LQ L R L +N PP +P + DL F+ EG + DGLVNF
Sbjct: 836 LFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNF 894
Query: 1216 SKMRMISHIIREI 1228
K+RMI+ IR +
Sbjct: 895 EKLRMIAKEIRHV 907
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,303,600
Number of Sequences: 37866
Number of extensions: 2059042
Number of successful extensions: 9420
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 8691
Number of HSP's gapped (non-prelim): 858
length of query: 1273
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1159
effective length of database: 13,930,794
effective search space: 16145790246
effective search space used: 16145790246
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.