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Search of human proteins with 24429566
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 928 0.0
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 761 0.0
gi|9506959 phosphodiesterase 7B [Homo sapiens] 550 e-156
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 209 3e-54
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 209 3e-54
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 209 3e-54
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 209 3e-54
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 209 5e-54
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 209 5e-54
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 209 5e-54
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 209 5e-54
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 208 9e-54
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 208 9e-54
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 208 9e-54
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 208 9e-54
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 208 9e-54
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 191 1e-48
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 191 1e-48
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 184 1e-46
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 179 5e-45
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 179 5e-45
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 179 5e-45
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 179 5e-45
gi|4505677 phosphodiesterase 1B [Homo sapiens] 175 9e-44
gi|4826894 phosphodiesterase 1C [Homo sapiens] 173 3e-43
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 171 1e-42
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 171 1e-42
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 158 8e-39
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 158 8e-39
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 158 8e-39
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 928 bits (2398), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP 60
MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP
Sbjct: 1 MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHP 60
Query: 61 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC
Sbjct: 61 YIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH
Sbjct: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
Sbjct: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ 300
TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQ 300
Query: 301 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 360
NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH
Sbjct: 301 NEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFH 360
Query: 361 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL 420
QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL
Sbjct: 361 QGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGL 420
Query: 421 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 456
NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
Sbjct: 421 NKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS 456
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 761 bits (1964), Expect = 0.0
Identities = 373/376 (99%), Positives = 374/376 (99%)
Query: 19 SKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS 78
S+RRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS
Sbjct: 45 SQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVS 104
Query: 79 ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL 138
ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL
Sbjct: 105 ARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRL 164
Query: 139 TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM 198
TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM
Sbjct: 165 TNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAM 224
Query: 199 HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 258
HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH
Sbjct: 225 HCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENH 284
Query: 259 HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 318
HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL
Sbjct: 285 HWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCL 344
Query: 319 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR 378
EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR
Sbjct: 345 EDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDR 404
Query: 379 HTESIANIQIGFMTYL 394
HTESIANIQIG TYL
Sbjct: 405 HTESIANIQIGNYTYL 420
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 550 bits (1417), Expect = e-156
Identities = 261/423 (61%), Positives = 331/423 (78%), Gaps = 1/423 (0%)
Query: 20 KRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSA 79
+R G I +++ DQ A + MLGD+R+R + G +ERRGS+P+IDFR+ +S + +
Sbjct: 7 ERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTK 66
Query: 80 RNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLT 139
+ ++RLLSFQRY +SR RG L++LD+DY GQA+ ML KVG W+FDIFLFDRLT
Sbjct: 67 KKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLT 126
Query: 140 NGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMH 199
NGNSLV+L HLF+ HGLI +F LDM+ L RFLVM+QEDYHSQNPYHNAVHAADVTQAMH
Sbjct: 127 NGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMH 186
Query: 200 CYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHH 259
CYLKEPKLA+ +TP DI+L L+AAA HD+DHPGVNQPFLIKTNH+LA LY+N SVLENHH
Sbjct: 187 CYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHH 246
Query: 260 WRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE 319
WRS +G+LRES L +HLP E Q +E Q+G+LILATDI+RQNE+L+ ++HL DL LE
Sbjct: 247 WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLE 306
Query: 320 DTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRH 379
D + RH +LQ+ALKCADICNPCR WE+SKQWSE+V EEF+ QG++E+K+ L +SPLC++
Sbjct: 307 DAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQ 366
Query: 380 TESIANIQIGFMTYLVEPLFTEWARFS-NTRLSQTMLGHVGLNKASWKGLQREQSSSEDT 438
+SI +IQIGFM+Y+VEPLF EWA F+ N+ LS+ MLGH+ NKA WK L Q S +
Sbjct: 367 KDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGS 426
Query: 439 DAA 441
+
Sbjct: 427 SGS 429
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 209 bits (533), Expect = 3e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 368 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 427
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 428 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 487
Query: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 488 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 547
Query: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 548 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 597
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 209 bits (533), Expect = 3e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 403 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 462
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 463 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 522
Query: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 523 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 582
Query: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 583 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 632
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 209 bits (533), Expect = 3e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 429 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 488
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 489 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 548
Query: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 549 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 608
Query: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 609 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 658
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 209 bits (533), Expect = 3e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 190 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 249
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 250 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 309
Query: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 310 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 369
Query: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 370 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 419
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 209 bits (531), Expect = 5e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 263 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 322
Query: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 323 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 379
Query: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 380 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 439
Query: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 440 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 499
Query: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 500 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 559
Query: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 560 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 619
Query: 392 TYLVEPLFTEWA 403
Y+V PL+ WA
Sbjct: 620 DYIVHPLWETWA 631
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 209 bits (531), Expect = 5e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 248 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 307
Query: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 308 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 364
Query: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 365 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 424
Query: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 425 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 484
Query: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 485 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 544
Query: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 545 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 604
Query: 392 TYLVEPLFTEWA 403
Y+V PL+ WA
Sbjct: 605 DYIVHPLWETWA 616
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 209 bits (531), Expect = 5e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 91 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 150
Query: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 151 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 207
Query: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 208 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 267
Query: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 268 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 327
Query: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 328 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 387
Query: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 388 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 447
Query: 392 TYLVEPLFTEWA 403
Y+V PL+ WA
Sbjct: 448 DYIVHPLWETWA 459
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 209 bits (531), Expect = 5e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 263 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 322
Query: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 323 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 379
Query: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 380 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 439
Query: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 440 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 499
Query: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 500 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 559
Query: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 560 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 619
Query: 392 TYLVEPLFTEWA 403
Y+V PL+ WA
Sbjct: 620 DYIVHPLWETWA 631
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 208 bits (529), Expect = 9e-54
Identities = 126/411 (30%), Positives = 215/411 (52%), Gaps = 19/411 (4%)
Query: 5 LIWCLALVLIKWITSKRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYID 63
L WCL + T + R ++S +S++ + R L + SR+G + S+ ++D
Sbjct: 284 LDWCLDQLE----TLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLD 339
Query: 64 FRI---FHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
+ S ++ E R + ++ ++ + SS + + +D +
Sbjct: 340 KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE-- 397
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
LE V W +F L+ L + +F L++ F + + L +L+ +++ YH
Sbjct: 398 -LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYH 456
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
+ YHN +HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI
Sbjct: 457 ADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS 298
TN LA +Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S
Sbjct: 517 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 576
Query: 299 RQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSE 352
+ L+ ++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++
Sbjct: 577 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 636
Query: 353 KVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
++ EEFF QGD E++ + +SP+CD+H S+ Q+GF+ Y+V PL+ WA
Sbjct: 637 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA 687
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 208 bits (529), Expect = 9e-54
Identities = 126/411 (30%), Positives = 215/411 (52%), Gaps = 19/411 (4%)
Query: 5 LIWCLALVLIKWITSKRRGAISYDSSDQTALYI-RMLGDVRVRSRAGFESERRGSHPYID 63
L WCL + T + R ++S +S++ + R L + SR+G + S+ ++D
Sbjct: 148 LDWCLDQLE----TLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLD 203
Query: 64 FRI---FHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKC 120
+ S ++ E R + ++ ++ + SS + + +D +
Sbjct: 204 KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE-- 261
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
LE V W +F L+ L + +F L++ F + + L +L+ +++ YH
Sbjct: 262 -LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYH 320
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
+ YHN +HAADV Q+ H L P L T +IL ++ A+A HD+DHPGV+ FLI
Sbjct: 321 ADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDIS 298
TN LA +Y ++SVLENHH LL+E +F +L + RQ + + ++LATD+S
Sbjct: 381 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 440
Query: 299 RQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSE 352
+ L+ ++ ++ G L L++ R VLQ + CAD+ NP + +L +QW++
Sbjct: 441 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 500
Query: 353 KVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
++ EEFF QGD E++ + +SP+CD+H S+ Q+GF+ Y+V PL+ WA
Sbjct: 501 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA 551
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 208 bits (529), Expect = 9e-54
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
Query: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
Query: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 388
Query: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 389 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 448
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 449 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 507
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 208 bits (529), Expect = 9e-54
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
Query: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
Query: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
Query: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 581
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 208 bits (529), Expect = 9e-54
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
Query: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
Query: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 494
Query: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 495 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 554
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 555 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 613
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 191 bits (485), Expect = 1e-48
Identities = 114/366 (31%), Positives = 190/366 (51%), Gaps = 24/366 (6%)
Query: 84 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 143
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 408 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 467
Query: 144 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 203
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 468 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 527
Query: 204 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 263
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 528 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 587
Query: 264 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 320
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 588 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 647
Query: 321 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 363
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 648 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 707
Query: 364 IEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNK 422
EK+ L V P+ DR+T SI QI F+ Y + +F W F + ++ H+ N
Sbjct: 708 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDL---PDLMQHLDNNF 764
Query: 423 ASWKGL 428
WKGL
Sbjct: 765 KYWKGL 770
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 191 bits (485), Expect = 1e-48
Identities = 114/366 (31%), Positives = 190/366 (51%), Gaps = 24/366 (6%)
Query: 84 RLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNS 143
R LS Y+ S++ + + + I DD + +E W+FDIF + T+
Sbjct: 454 RRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRP 513
Query: 144 LVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLK 203
L+ L +F+ G+ E+ H LR +L +I+ +YHS NPYHN+ H+ADV A +L
Sbjct: 514 LIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLS 573
Query: 204 EPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 263
+ ++ ++ P D + +LIAA HD+DHPG FL LA LY +T+VLE+HH A
Sbjct: 574 KERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALA 633
Query: 264 VGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLED 320
L + +F ++ + + I ++LAT++++ E+++ F + +++ LE+
Sbjct: 634 FQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEE 693
Query: 321 T-----------------RHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGD 363
+R L+ +M +KCAD+ NPCR + +W+ +++EE+F Q D
Sbjct: 694 NGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTD 753
Query: 364 IEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNK 422
EK+ L V P+ DR+T SI QI F+ Y + +F W F + ++ H+ N
Sbjct: 754 EEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDL---PDLMQHLDNNF 810
Query: 423 ASWKGL 428
WKGL
Sbjct: 811 KYWKGL 816
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 184 bits (467), Expect = 1e-46
Identities = 123/407 (30%), Positives = 206/407 (50%), Gaps = 29/407 (7%)
Query: 42 DVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGT 101
DV+ S G ++ + Y HS + IE ++ +RRL S Y+ F +
Sbjct: 419 DVKSISSRGSDAPSLQNRRYPSMARIHSMT-IEAPITKDGLRRL-SGNEYV----FTKNV 472
Query: 102 AVSNSLNILDDDYNGQAKCMLEKVGN---WNFDIFLFDRLTNGNSLVSLTFHLFSLHGLI 158
S+S + N C+ + + N W+F+IF + +T+ LV L +FS G+
Sbjct: 473 HQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVC 532
Query: 159 EYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILL 218
E+ + LR + +I+ +YHS N YHN+ HAADV A +L + ++ S+ D +
Sbjct: 533 EFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVA 592
Query: 219 SLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSH 275
+LIAA HD+DHPG FL LA LY +T+VLE+HH A L + +F +
Sbjct: 593 ALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKN 652
Query: 276 LPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDR-------GDLC------LEDTR 322
+ + + I ++LAT++++ E+++ F + +++ G C
Sbjct: 653 IDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPE 712
Query: 323 HRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTE 381
++ L+ +M +KCAD+ NPCR +L +W+ +++EE+F Q D EK+ L V P+ DR+T
Sbjct: 713 NQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTC 772
Query: 382 SIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGL 428
SI QI F+ Y + +F W F++ ++ H+ N WK L
Sbjct: 773 SIPKSQISFIDYFITDMFDAWDAFAHL---PALMQHLADNYKHWKTL 816
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 179 bits (454), Expect = 5e-45
Identities = 104/325 (32%), Positives = 175/325 (53%), Gaps = 20/325 (6%)
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 503 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 562
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 563 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 622
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 297
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 623 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 682
Query: 298 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 344
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 683 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 742
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI F+ Y + +F W
Sbjct: 743 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 802
Query: 404 RFSNTRLSQTMLGHVGLNKASWKGL 428
F++ ++ H+ N WK L
Sbjct: 803 AFAHL---PALMQHLADNYKHWKTL 824
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 179 bits (454), Expect = 5e-45
Identities = 104/325 (32%), Positives = 175/325 (53%), Gaps = 20/325 (6%)
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 530 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 589
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 590 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 649
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 297
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 650 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 709
Query: 298 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 344
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 710 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 769
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI F+ Y + +F W
Sbjct: 770 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 829
Query: 404 RFSNTRLSQTMLGHVGLNKASWKGL 428
F++ ++ H+ N WK L
Sbjct: 830 AFAHL---PALMQHLADNYKHWKTL 851
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 179 bits (454), Expect = 5e-45
Identities = 104/325 (32%), Positives = 175/325 (53%), Gaps = 20/325 (6%)
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 453 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 512
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 513 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 572
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 297
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 573 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 632
Query: 298 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 344
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 633 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 692
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI F+ Y + +F W
Sbjct: 693 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 752
Query: 404 RFSNTRLSQTMLGHVGLNKASWKGL 428
F++ ++ H+ N WK L
Sbjct: 753 AFAHL---PALMQHLADNYKHWKTL 774
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 179 bits (454), Expect = 5e-45
Identities = 104/325 (32%), Positives = 175/325 (53%), Gaps = 20/325 (6%)
Query: 121 MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYH 180
+L+ +W+F+IF + +T+ LV L +FS G+ E+ + LR + +I+ +YH
Sbjct: 550 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 609
Query: 181 SQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
S N YHN+ HAADV A +L + ++ S+ D + +LIAA HD+DHPG FL
Sbjct: 610 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 669
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLL---RESGLFSHLPLESRQQMETQIGALILATDI 297
LA LY +T+VLE+HH A L + +F ++ + + I ++LAT++
Sbjct: 670 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 729
Query: 298 SRQNEYLSLFRSHLDR-------GDLC------LEDTRHRHLVLQMALKCADICNPCRTW 344
++ E+++ F + +++ G C ++ L+ +M +KCAD+ NPCR
Sbjct: 730 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 789
Query: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLG-VSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
+L +W+ +++EE+F Q D EK+ L V P+ DR+T SI QI F+ Y + +F W
Sbjct: 790 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 849
Query: 404 RFSNTRLSQTMLGHVGLNKASWKGL 428
F++ ++ H+ N WK L
Sbjct: 850 AFAHL---PALMQHLADNYKHWKTL 871
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 175 bits (443), Expect = 9e-44
Identities = 100/308 (32%), Positives = 165/308 (53%), Gaps = 13/308 (4%)
Query: 96 RFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLH 155
R FR T S + Y+ L+ + W FD+F ++ + ++L ++ F L + H
Sbjct: 137 RMFRRTYTS-----VGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
Query: 156 GLIEYFHLDMMKLRRFLVMIQEDYHS-QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 214
LI F + + L FL ++ Y +NPYHN +HAADVTQ +HC+L + + ++
Sbjct: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
Query: 215 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR--ESGL 272
++L + AAA HD +H G F I+T A +Y + SVLENHH S L++ E +
Sbjct: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
Query: 273 FSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMAL 332
F +L + ++ + ++LATD+S + + ++ L + + + L + L
Sbjct: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ-----LERIDKPKALSLLL 366
Query: 333 KCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMT 392
ADI +P + W + +W++ + EEFF QGD E + L SPLCDR + +A QIGF+
Sbjct: 367 HAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFID 426
Query: 393 YLVEPLFT 400
++VEP F+
Sbjct: 427 FIVEPTFS 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 173 bits (439), Expect = 3e-43
Identities = 95/283 (33%), Positives = 156/283 (55%), Gaps = 9/283 (3%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
L+ V W+FD+F + + ++L + + L + + LI F + + L F+ ++ Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
+NPYHN +HAADVTQ +H L + +AN +T +I + +AA HD +H G F I+
Sbjct: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDI 297
T A LY + SVLENHH +A LL+ E + +L + ++ T + +++ATD+
Sbjct: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
Query: 298 SRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEE 357
S + + ++ L + + + L + L ADI +P + W+L +W+ + EE
Sbjct: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
Query: 358 FFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400
FF QGD E + L SPLCDR + +A Q+GF+ ++VEP FT
Sbjct: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFT 440
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 171 bits (433), Expect = 1e-42
Identities = 95/282 (33%), Positives = 156/282 (55%), Gaps = 8/282 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 298
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 299 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 358
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
Query: 359 FHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400
F QGD E + L SPLCDR + +A QIGF+ ++VEP F+
Sbjct: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFS 430
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 171 bits (433), Expect = 1e-42
Identities = 95/282 (33%), Positives = 156/282 (55%), Gaps = 8/282 (2%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 298
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 299 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 358
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
Query: 359 FHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400
F QGD E + L SPLCDR + +A QIGF+ ++VEP F+
Sbjct: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFS 430
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 158 bits (400), Expect = 8e-39
Identities = 94/280 (33%), Positives = 152/280 (54%), Gaps = 9/280 (3%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 46 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 101
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 102 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 160
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 299
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 161 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 220
Query: 300 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 359
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 221 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 278
Query: 360 HQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLF 399
Q D EK L V+P DR + A QIGF+ +++ P+F
Sbjct: 279 MQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF 318
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 158 bits (400), Expect = 8e-39
Identities = 94/280 (33%), Positives = 152/280 (54%), Gaps = 9/280 (3%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 46 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 101
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 102 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 160
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 299
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 161 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 220
Query: 300 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 359
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 221 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 278
Query: 360 HQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLF 399
Q D EK L V+P DR + A QIGF+ +++ P+F
Sbjct: 279 MQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF 318
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 158 bits (400), Expect = 8e-39
Identities = 94/280 (33%), Positives = 152/280 (54%), Gaps = 9/280 (3%)
Query: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
+E + FD++L++ N ++S H++ GL+ F ++ + LRR+L + ++Y +
Sbjct: 227 IEALRKPTFDVWLWEP----NEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRN 282
Query: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
NP+HN H V Q M+ + L + DIL+ + AA HDLDHPG N + I
Sbjct: 283 -NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINA 341
Query: 242 NHYLATLYKNTSVLENHHWRSAVGLLR--ESGLFSHLPLESRQQMETQIGALILATDISR 299
LA Y + S LENHH A +L E +FS++P + +Q+ + LILATD++R
Sbjct: 342 RTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMAR 401
Query: 300 QNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFF 359
E + F+ ++ D E+ H L+ + +KC DI N R E+++ W + + EE+F
Sbjct: 402 HAEIMDSFKEKMENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYF 459
Query: 360 HQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLF 399
Q D EK L V+P DR + A QIGF+ +++ P+F
Sbjct: 460 MQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,610,880
Number of Sequences: 37866
Number of extensions: 624231
Number of successful extensions: 1539
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1323
Number of HSP's gapped (non-prelim): 75
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.