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Search of human proteins with 24308073
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308073 protein tyrosine phosphatase, non-receptor type 23
[Homo sapiens]
(1636 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [... 3318 0.0
gi|22027538 programmed cell death 6 interacting protein isoform ... 258 4e-68
gi|241982780 programmed cell death 6 interacting protein isoform... 257 7e-68
gi|4506291 protein tyrosine phosphatase, non-receptor type 2 iso... 153 2e-36
gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [H... 153 2e-36
gi|18104980 protein tyrosine phosphatase, non-receptor type 2 is... 153 2e-36
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 145 3e-34
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 138 4e-32
gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Ho... 137 7e-32
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 137 7e-32
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 137 7e-32
gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Ho... 135 2e-31
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 134 9e-31
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 134 9e-31
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 134 9e-31
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 134 9e-31
gi|119120915 rhophilin 1 [Homo sapiens] 134 9e-31
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 133 1e-30
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 133 1e-30
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 133 1e-30
gi|196114951 protein tyrosine phosphatase, non-receptor type 12 ... 133 2e-30
gi|160707881 formin 2 [Homo sapiens] 132 3e-30
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 131 6e-30
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 131 6e-30
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 131 6e-30
>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
sapiens]
Length = 1636
Score = 3318 bits (8602), Expect = 0.0
Identities = 1636/1636 (100%), Positives = 1636/1636 (100%)
Query: 1 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR 60
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR
Sbjct: 1 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR 60
Query: 61 DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN 120
DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN
Sbjct: 61 DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN 120
Query: 121 LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL 180
LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL
Sbjct: 121 LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL 180
Query: 181 MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL 240
MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL
Sbjct: 181 MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL 240
Query: 241 VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF 300
VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
Sbjct: 241 VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF 300
Query: 301 TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL 360
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL
Sbjct: 301 TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL 360
Query: 361 VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ 420
VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ
Sbjct: 361 VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ 420
Query: 421 LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA 480
LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA
Sbjct: 421 LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA 480
Query: 481 GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL 540
GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL
Sbjct: 481 GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL 540
Query: 541 PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK 600
PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK
Sbjct: 541 PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK 600
Query: 601 LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA 660
LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA
Sbjct: 601 LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA 660
Query: 661 SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP 720
SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP
Sbjct: 661 SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP 720
Query: 721 TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST 780
TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST
Sbjct: 721 TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST 780
Query: 781 GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ 840
GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ
Sbjct: 781 GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ 840
Query: 841 HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN 900
HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN
Sbjct: 841 HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN 900
Query: 901 PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ 960
PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ
Sbjct: 901 PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ 960
Query: 961 PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP 1020
PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP
Sbjct: 961 PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP 1020
Query: 1021 GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP 1080
GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP
Sbjct: 1021 GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP 1080
Query: 1081 SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL 1140
SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL
Sbjct: 1081 SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL 1140
Query: 1141 LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD 1200
LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD
Sbjct: 1141 LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD 1200
Query: 1201 AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV 1260
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV
Sbjct: 1201 AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV 1260
Query: 1261 ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL 1320
ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
Sbjct: 1261 ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL 1320
Query: 1321 SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH 1380
SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH
Sbjct: 1321 SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH 1380
Query: 1381 QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL 1440
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
Sbjct: 1381 QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL 1440
Query: 1441 HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA 1500
HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA
Sbjct: 1441 HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA 1500
Query: 1501 TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE 1560
TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE
Sbjct: 1501 TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE 1560
Query: 1561 EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS 1620
EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS
Sbjct: 1561 EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS 1620
Query: 1621 DDPLSLLDPLWTLNKT 1636
DDPLSLLDPLWTLNKT
Sbjct: 1621 DDPLSLLDPLWTLNKT 1636
>gi|22027538 programmed cell death 6 interacting protein isoform 1
[Homo sapiens]
Length = 868
Score = 258 bits (658), Expect = 4e-68
Identities = 237/895 (26%), Positives = 409/895 (45%), Gaps = 71/895 (7%)
Query: 10 IWLDLKEAGDFHFQPAVKKFVLKNY---GENPEAYNEELKKLELLRQNAVRVPRD-FEGC 65
I + LK+ + + KF+ + Y GE Y ++L LR+ AV P D EG
Sbjct: 5 ISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGA 64
Query: 66 -SVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIK-------YEQACI 117
L +Y Q+ ++ + P Q + TW + F S+ +K YE++C+
Sbjct: 65 LETLLRYYDQICSIEPKFPFSENQ-ICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCV 123
Query: 118 LYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYS----VDMSRQI 173
L+N AL S + A ++EG+K++ H+Q A+GAF +++E A S VD+S
Sbjct: 124 LFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDT 183
Query: 174 LTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRI 233
+ +ML QAQE K+ D K ++A+++ Q DY+ +A + + DT +
Sbjct: 184 VGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDT------L 237
Query: 234 QKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDT 293
K+ ++ K A A H A++Q+KFGE +A Q A E IK + D
Sbjct: 238 PKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAA----ELIKTVASRYDE 293
Query: 294 VQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVN-PTDPAVT 352
+ F+ D I +AKKDNDFIYH+ VP L L P+ A LVK PVN P T
Sbjct: 294 YVNVKDFS-DKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFT 352
Query: 353 GPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLD 412
D+F K+VP++ ++ + Y++ KA L+ +A++ + + + + S+ L P ++++
Sbjct: 353 --DLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNL-PAAIEDVS 409
Query: 413 AYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDEL---- 468
+P ++ K ++ + ++ + Q ++ L + L + LL+E+E
Sbjct: 410 G-DTVPQSILTKSRSV-IEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDND 467
Query: 469 LEQKFQEAVGQAGAISITSKAELAE-VRREWAKYMEVHEKASFTNSELHRAMNLHVGNLR 527
L KF+E + T EL + +R E + V +KA + ++ H +
Sbjct: 468 LRAKFKERWQR------TPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIV 521
Query: 528 LLSGPLDQVRAALPT--PALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDD 585
LL P ++ AA+P+ PA + + V+ LK +L+ + E++ +R LE L+ + D
Sbjct: 522 LLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSV--NFD 579
Query: 586 ITASLVTTDHSEMKKLFEEQL------KKYDQLKVYLEQNLAAQDRVLCALTEANVQYAA 639
+T+ +T ++ + EE L + Y L ++++L Q+ +L + ++ +++
Sbjct: 580 MTSKFLTA-LAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSK 638
Query: 640 VRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQA 699
+++ ++ + + L+ L +Y+ + +L+ +EG FY +L + + A
Sbjct: 639 MKQSNNEANLR-EEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFA 697
Query: 700 REAARQQLLDRELKKKPPPRPTAPKPLLPRREESEA-VEAGDPPEEL-RSLPPDMVAGPR 757
R+ R +LL ++L++ P+AP P + S A A PP R++PP P
Sbjct: 698 RKTERDELL-KDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPA 756
Query: 758 L--PDTFLGSATPLHFPPSPFPSST-GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMP 814
P + P PSP + T P P G PP GP P PG MP
Sbjct: 757 RPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMP 816
Query: 815 VAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFS 869
+ G Y Y V SP +PY P P P PPQ S
Sbjct: 817 MPMGYNPYAYGQYNMPYPPVYHQSPG----QAPY----PGPQQPSYPFPQPPQQS 863
Score = 59.7 bits (143), Expect = 2e-08
Identities = 46/170 (27%), Positives = 61/170 (35%), Gaps = 23/170 (13%)
Query: 879 PATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHF 938
P+ T +P H P P P PP P PP +P P P+
Sbjct: 720 PSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGA 779
Query: 939 SSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPY 998
+ PA P P PQ P+P+ P Q P+P+ + +PY
Sbjct: 780 GTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGY---------------NPY 824
Query: 999 PYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPP 1048
Y G P PP++ Q PG A P P +P P PPQ + P
Sbjct: 825 AY----GQYNMPYPPVYHQ-SPGQAPYPGPQQPS---YPFPQPPQQSYYP 866
Score = 58.5 bits (140), Expect = 5e-08
Identities = 52/163 (31%), Positives = 65/163 (39%), Gaps = 21/163 (12%)
Query: 951 IGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQP 1010
I +P P P+ P P P P AP +PP P P A +P
Sbjct: 713 IAREPSAPSIPTPAYQSSPAGGHAPTP-------PTPAPRTMPPTKPQPPA-------RP 758
Query: 1011 PPPLHTQLYPGPAQDPLPAHSG-ALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTI 1069
PPP+ A P P +G A P PS P P PP A GP T P P + +
Sbjct: 759 PPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAP-PPQAQGPPYPTYPGYPGYCQMPM 817
Query: 1070 ---RGPSSAGQ-STPSPHLV-PSPAPSPGPGPVPPRPPAAEPP 1107
P + GQ + P P + SP +P PGP P P +PP
Sbjct: 818 PMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPP 860
Score = 52.4 bits (124), Expect = 4e-06
Identities = 47/148 (31%), Positives = 57/148 (38%), Gaps = 16/148 (10%)
Query: 837 SSPQHGVVSSPYVGVGPAPPVAGLPSAPP-----PQFSGPELAMAVRPATTTVDSIQAPI 891
S P SSP G P PP + PP P P + A R + T S
Sbjct: 721 SIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAG 780
Query: 892 PSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRI 951
+ AP P APPP P PT YP + P+P ++ + P P +
Sbjct: 781 TAAPAPSQTPGSAPPPQA----QGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPV 836
Query: 952 -----GPQPQPHPQPHPSQAFGPQPPQQ 974
G P P PQ PS F PQPPQQ
Sbjct: 837 YHQSPGQAPYPGPQ-QPSYPF-PQPPQQ 862
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/159 (30%), Positives = 55/159 (34%), Gaps = 14/159 (8%)
Query: 911 PVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQ 970
P P P P + PAG P P + +P P P P P P A P
Sbjct: 717 PSAPSIPTPAYQSSPAGGHAPTPPTPAPRT-MPPTKPQPPARPPPPVLPANRAPSATAPS 775
Query: 971 PPQQPLPLQHPHLFPPQAPGLLPPQS---PYP-YAPQPGVLGQPPPPLHTQLYPGPAQDP 1026
P P P AP PPQ+ PYP Y PG P P + G P
Sbjct: 776 PVGAGTAAPAPSQTPGSAP---PPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMP 832
Query: 1027 LPA--HSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQ 1063
P H P PGP QP +P P P + PQ
Sbjct: 833 YPPVYHQSPGQAPYPGPQQPSYP----FPQPPQQSYYPQ 867
Score = 42.4 bits (98), Expect = 0.004
Identities = 34/93 (36%), Positives = 40/93 (43%), Gaps = 17/93 (18%)
Query: 1020 PGPAQDPLPA--HSGALPFPSPG--PPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSA 1075
P PA PA H+ P P+P PP P PP P P P +A T P A
Sbjct: 723 PTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPAR--PPPPVLPAN-RAPSATAPSPVGA 779
Query: 1076 GQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPP 1108
G + +PAPS PG P PP A+ PP
Sbjct: 780 GTA--------APAPSQTPGSAP--PPQAQGPP 802
Score = 38.5 bits (88), Expect = 0.054
Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 10/80 (12%)
Query: 1039 PGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVP------SPAPSP 1092
P P P P PA P P AP T+ + P P ++P + APSP
Sbjct: 717 PSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSP 776
Query: 1093 -GPG---PVPPRPPAAEPPP 1108
G G P P + P + PPP
Sbjct: 777 VGAGTAAPAPSQTPGSAPPP 796
Score = 35.0 bits (79), Expect = 0.60
Identities = 30/112 (26%), Positives = 44/112 (39%), Gaps = 14/112 (12%)
Query: 1466 CKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAE 1525
C + A ++++ L +D Q SI + SI P SP G A
Sbjct: 691 CSDIVFARKTERDELLKDLQQ----------SIAREPSAPSIPTPAYQSSPAG---GHAP 737
Query: 1526 PPGLP-PASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSS 1576
P P P ++P + P P + PPP P AP PV ++ PS +
Sbjct: 738 TPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQT 789
Score = 32.7 bits (73), Expect = 3.0
Identities = 22/79 (27%), Positives = 29/79 (36%), Gaps = 4/79 (5%)
Query: 1490 GGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLS 1549
GG P A +P P LP P P+ + T P+ S P S
Sbjct: 733 GGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGS 792
Query: 1550 SPLPEAPQPKEEPPVPEAP 1568
+P P+A + PP P P
Sbjct: 793 APPPQA----QGPPYPTYP 807
>gi|241982780 programmed cell death 6 interacting protein isoform 2
[Homo sapiens]
Length = 873
Score = 257 bits (656), Expect = 7e-68
Identities = 238/895 (26%), Positives = 408/895 (45%), Gaps = 66/895 (7%)
Query: 10 IWLDLKEAGDFHFQPAVKKFVLKNY---GENPEAYNEELKKLELLRQNAVRVPRD-FEGC 65
I + LK+ + + KF+ + Y GE Y ++L LR+ AV P D EG
Sbjct: 5 ISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDKHEGA 64
Query: 66 -SVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIK-------YEQACI 117
L +Y Q+ ++ + P Q + TW + F S+ +K YE++C+
Sbjct: 65 LETLLRYYDQICSIEPKFPFSENQ-ICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCV 123
Query: 118 LYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYS----VDMSRQI 173
L+N AL S + A ++EG+K++ H+Q A+GAF +++E A S VD+S
Sbjct: 124 LFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDISPDT 183
Query: 174 LTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRI 233
+ +ML QAQE K+ D K ++A+++ Q DY+ +A + + DT
Sbjct: 184 VGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKYFYF 243
Query: 234 QKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDT 293
Q+ + L K A A H A++Q+KFGE +A Q A E IK + D
Sbjct: 244 QEVFPVLA-AKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAA----ELIKTVASRYDE 298
Query: 294 VQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVN-PTDPAVT 352
+ F+ D I +AKKDNDFIYH+ VP L L P+ A LVK PVN P T
Sbjct: 299 YVNVKDFS-DKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFT 357
Query: 353 GPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLD 412
D+F K+VP++ ++ + Y++ KA L+ +A++ + + + + S+ L P ++++
Sbjct: 358 --DLFEKMVPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNL-PAAIEDVS 414
Query: 413 AYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDEL---- 468
+P ++ K ++ + ++ + Q ++ L + L + LL+E+E
Sbjct: 415 G-DTVPQSILTKSRSV-IEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDND 472
Query: 469 LEQKFQEAVGQAGAISITSKAELAE-VRREWAKYMEVHEKASFTNSELHRAMNLHVGNLR 527
L KF+E + T EL + +R E + V +KA + ++ H +
Sbjct: 473 LRAKFKERWQR------TPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIV 526
Query: 528 LLSGPLDQVRAALPT--PALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDD 585
LL P ++ AA+P+ PA + + V+ LK +L+ + E++ +R LE L+ + D
Sbjct: 527 LLCKPEPELNAAIPSANPAKTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSV--NFD 584
Query: 586 ITASLVTTDHSEMKKLFEEQL------KKYDQLKVYLEQNLAAQDRVLCALTEANVQYAA 639
+T+ +T ++ + EE L + Y L ++++L Q+ +L + ++ +++
Sbjct: 585 MTSKFLTA-LAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSK 643
Query: 640 VRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQA 699
+++ ++ + + L+ L +Y+ + +L+ +EG FY +L + + A
Sbjct: 644 MKQSNNEANLR-EEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFA 702
Query: 700 REAARQQLLDRELKKKPPPRPTAPKPLLPRREESEA-VEAGDPPEEL-RSLPPDMVAGPR 757
R+ R +LL ++L++ P+AP P + S A A PP R++PP P
Sbjct: 703 RKTERDELL-KDLQQSIAREPSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPA 761
Query: 758 L--PDTFLGSATPLHFPPSPFPSST-GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMP 814
P + P PSP + T P P G PP GP P PG MP
Sbjct: 762 RPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMP 821
Query: 815 VAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFS 869
+ G Y Y V SP +PY P P P PPQ S
Sbjct: 822 MPMGYNPYAYGQYNMPYPPVYHQSPG----QAPY----PGPQQPSYPFPQPPQQS 868
Score = 59.7 bits (143), Expect = 2e-08
Identities = 46/170 (27%), Positives = 61/170 (35%), Gaps = 23/170 (13%)
Query: 879 PATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHF 938
P+ T +P H P P P PP P PP +P P P+
Sbjct: 725 PSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGA 784
Query: 939 SSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPY 998
+ PA P P PQ P+P+ P Q P+P+ + +PY
Sbjct: 785 GTAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGY---------------NPY 829
Query: 999 PYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPP 1048
Y G P PP++ Q PG A P P +P P PPQ + P
Sbjct: 830 AY----GQYNMPYPPVYHQ-SPGQAPYPGPQQPS---YPFPQPPQQSYYP 871
Score = 58.5 bits (140), Expect = 5e-08
Identities = 52/163 (31%), Positives = 65/163 (39%), Gaps = 21/163 (12%)
Query: 951 IGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQP 1010
I +P P P+ P P P P AP +PP P P A +P
Sbjct: 718 IAREPSAPSIPTPAYQSSPAGGHAPTP-------PTPAPRTMPPTKPQPPA-------RP 763
Query: 1011 PPPLHTQLYPGPAQDPLPAHSG-ALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTI 1069
PPP+ A P P +G A P PS P P PP A GP T P P + +
Sbjct: 764 PPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGSAP-PPQAQGPPYPTYPGYPGYCQMPM 822
Query: 1070 ---RGPSSAGQ-STPSPHLV-PSPAPSPGPGPVPPRPPAAEPP 1107
P + GQ + P P + SP +P PGP P P +PP
Sbjct: 823 PMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPSYPFPQPP 865
Score = 52.4 bits (124), Expect = 4e-06
Identities = 47/148 (31%), Positives = 57/148 (38%), Gaps = 16/148 (10%)
Query: 837 SSPQHGVVSSPYVGVGPAPPVAGLPSAPP-----PQFSGPELAMAVRPATTTVDSIQAPI 891
S P SSP G P PP + PP P P + A R + T S
Sbjct: 726 SIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAG 785
Query: 892 PSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRI 951
+ AP P APPP P PT YP + P+P ++ + P P +
Sbjct: 786 TAAPAPSQTPGSAPPPQA----QGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPV 841
Query: 952 -----GPQPQPHPQPHPSQAFGPQPPQQ 974
G P P PQ PS F PQPPQQ
Sbjct: 842 YHQSPGQAPYPGPQ-QPSYPF-PQPPQQ 867
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/159 (30%), Positives = 55/159 (34%), Gaps = 14/159 (8%)
Query: 911 PVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQ 970
P P P P + PAG P P + +P P P P P P A P
Sbjct: 722 PSAPSIPTPAYQSSPAGGHAPTPPTPAPRT-MPPTKPQPPARPPPPVLPANRAPSATAPS 780
Query: 971 PPQQPLPLQHPHLFPPQAPGLLPPQS---PYP-YAPQPGVLGQPPPPLHTQLYPGPAQDP 1026
P P P AP PPQ+ PYP Y PG P P + G P
Sbjct: 781 PVGAGTAAPAPSQTPGSAP---PPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMP 837
Query: 1027 LPA--HSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQ 1063
P H P PGP QP +P P P + PQ
Sbjct: 838 YPPVYHQSPGQAPYPGPQQPSYP----FPQPPQQSYYPQ 872
Score = 42.4 bits (98), Expect = 0.004
Identities = 34/93 (36%), Positives = 40/93 (43%), Gaps = 17/93 (18%)
Query: 1020 PGPAQDPLPA--HSGALPFPSPG--PPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSA 1075
P PA PA H+ P P+P PP P PP P P P +A T P A
Sbjct: 728 PTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPAR--PPPPVLPAN-RAPSATAPSPVGA 784
Query: 1076 GQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPP 1108
G + +PAPS PG P PP A+ PP
Sbjct: 785 GTA--------APAPSQTPGSAP--PPQAQGPP 807
Score = 38.5 bits (88), Expect = 0.054
Identities = 26/80 (32%), Positives = 33/80 (41%), Gaps = 10/80 (12%)
Query: 1039 PGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVP------SPAPSP 1092
P P P P PA P P AP T+ + P P ++P + APSP
Sbjct: 722 PSAPSIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSP 781
Query: 1093 -GPG---PVPPRPPAAEPPP 1108
G G P P + P + PPP
Sbjct: 782 VGAGTAAPAPSQTPGSAPPP 801
Score = 35.0 bits (79), Expect = 0.60
Identities = 30/112 (26%), Positives = 44/112 (39%), Gaps = 14/112 (12%)
Query: 1466 CKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAE 1525
C + A ++++ L +D Q SI + SI P SP G A
Sbjct: 696 CSDIVFARKTERDELLKDLQQ----------SIAREPSAPSIPTPAYQSSPAG---GHAP 742
Query: 1526 PPGLP-PASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSS 1576
P P P ++P + P P + PPP P AP PV ++ PS +
Sbjct: 743 TPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQT 794
Score = 32.7 bits (73), Expect = 3.0
Identities = 22/79 (27%), Positives = 29/79 (36%), Gaps = 4/79 (5%)
Query: 1490 GGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLS 1549
GG P A +P P LP P P+ + T P+ S P S
Sbjct: 738 GGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAGTAAPAPSQTPGS 797
Query: 1550 SPLPEAPQPKEEPPVPEAP 1568
+P P+A + PP P P
Sbjct: 798 APPPQA----QGPPYPTYP 812
>gi|4506291 protein tyrosine phosphatase, non-receptor type 2 isoform
1 [Homo sapiens]
Length = 415
Score = 153 bits (386), Expect = 2e-36
Identities = 86/257 (33%), Positives = 142/257 (55%), Gaps = 4/257 (1%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHE 1279
+NR++DV PYD +RV L++ ++DYINAS V+ + + TQ PLP T FWLMV +
Sbjct: 45 RNRYRDVSPYDHSRVKLQNAENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQ 103
Query: 1280 QKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV-HGALSLALSSVRSTETHVERVLSLQF 1338
QK +VML E E K A+Y+PT+ + + S+ L S + +L L+
Sbjct: 104 QKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLEN 163
Query: 1339 RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGR 1398
+ R++ H H+ TWP+ G+P+SP++ L F+ +V P H P ++HCS+G+GR
Sbjct: 164 INSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG-SLNPDHGPAVIHCSAGIGR 222
Query: 1399 TGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ 1458
+G F+L+ + +E G+ I + Q++ MR+ R ++Q LRF Y A++ + +
Sbjct: 223 SGTFSLVDTCLVLMEKGDDI-NIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKG 281
Query: 1459 RHGVPPPCKPLASASIS 1475
+ K L+ +S
Sbjct: 282 DSSIQKRWKELSKEDLS 298
>gi|18104982 protein tyrosine phosphatase, non-receptor type 2 [Homo
sapiens]
Length = 353
Score = 153 bits (386), Expect = 2e-36
Identities = 86/257 (33%), Positives = 142/257 (55%), Gaps = 4/257 (1%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHE 1279
+NR++DV PYD +RV L++ ++DYINAS V+ + + TQ PLP T FWLMV +
Sbjct: 45 RNRYRDVSPYDHSRVKLQNAENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQ 103
Query: 1280 QKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV-HGALSLALSSVRSTETHVERVLSLQF 1338
QK +VML E E K A+Y+PT+ + + S+ L S + +L L+
Sbjct: 104 QKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLEN 163
Query: 1339 RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGR 1398
+ R++ H H+ TWP+ G+P+SP++ L F+ +V P H P ++HCS+G+GR
Sbjct: 164 INSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG-SLNPDHGPAVIHCSAGIGR 222
Query: 1399 TGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ 1458
+G F+L+ + +E G+ I + Q++ MR+ R ++Q LRF Y A++ + +
Sbjct: 223 SGTFSLVDTCLVLMEKGDDI-NIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKG 281
Query: 1459 RHGVPPPCKPLASASIS 1475
+ K L+ +S
Sbjct: 282 DSSIQKRWKELSKEDLS 298
>gi|18104980 protein tyrosine phosphatase, non-receptor type 2 isoform
2 [Homo sapiens]
Length = 387
Score = 153 bits (386), Expect = 2e-36
Identities = 86/257 (33%), Positives = 142/257 (55%), Gaps = 4/257 (1%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHE 1279
+NR++DV PYD +RV L++ ++DYINAS V+ + + TQ PLP T FWLMV +
Sbjct: 45 RNRYRDVSPYDHSRVKLQNAENDYINASLVD-IEEAQRSYILTQGPLPNTCCHFWLMVWQ 103
Query: 1280 QKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV-HGALSLALSSVRSTETHVERVLSLQF 1338
QK +VML E E K A+Y+PT+ + + S+ L S + +L L+
Sbjct: 104 QKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLEN 163
Query: 1339 RDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGR 1398
+ R++ H H+ TWP+ G+P+SP++ L F+ +V P H P ++HCS+G+GR
Sbjct: 164 INSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESG-SLNPDHGPAVIHCSAGIGR 222
Query: 1399 TGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ 1458
+G F+L+ + +E G+ I + Q++ MR+ R ++Q LRF Y A++ + +
Sbjct: 223 SGTFSLVDTCLVLMEKGDDI-NIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKG 281
Query: 1459 RHGVPPPCKPLASASIS 1475
+ K L+ +S
Sbjct: 282 DSSIQKRWKELSKEDLS 298
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 341 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 399
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 400 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 458
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 459 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 514
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 515 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 572
Query: 1456 VL 1457
L
Sbjct: 573 GL 574
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 386 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 444
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 445 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 503
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 504 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 559
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 560 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 617
Query: 1456 VL 1457
L
Sbjct: 618 GL 619
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 497 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 555
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 556 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 614
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 615 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 670
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 671 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 728
Query: 1456 VL 1457
L
Sbjct: 729 GL 730
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 542 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 600
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 601 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 659
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 660 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 715
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 716 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 773
Query: 1456 VL 1457
L
Sbjct: 774 GL 775
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 628 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 686
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 687 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 745
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 746 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 801
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 802 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 859
Query: 1456 VL 1457
L
Sbjct: 860 GL 861
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 145 bits (366), Expect = 3e-34
Identities = 89/242 (36%), Positives = 134/242 (55%), Gaps = 12/242 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++DV+PYD+ RV+L+ G +DYINAS V P + +ATQ PLP T A FW +
Sbjct: 673 KNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQV 731
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
V +QK+S+IVML + E + K +Y+P + M HG + S T +V R + +
Sbjct: 732 VWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLV 790
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGV 1396
+ ++ HL + WP+ G+PD S+ L F+ V + R P++VHCS+G+
Sbjct: 791 TNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRVDSEPVLVHCSAGI 846
Query: 1397 GRTGAFALLYAAVQEVEAGNGIPELP-QLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
GRTG + A+ E +P P +VR+MR QR M+Q +F EA++R E+
Sbjct: 847 GRTGVLVTMETAMCLTE--RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE 904
Query: 1456 VL 1457
L
Sbjct: 905 GL 906
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 138 bits (348), Expect = 4e-32
Identities = 80/240 (33%), Positives = 130/240 (54%), Gaps = 11/240 (4%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPL---VATQAPLPGTAADFWLM 1276
KNR++D+ PYD+ RV+L+ G +DYINA+ + P + +A Q PLP T DFW M
Sbjct: 682 KNRYRDISPYDATRVILK-GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQM 740
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSL 1336
EQ S++VML ++ E + K +Y+P G +G + S ++ R ++L
Sbjct: 741 TWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSS-YGCYQVTCHSEEGNTAYIFRKMTL 799
Query: 1337 QFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRP-LHTPIIVHCSSG 1395
++++ R L + + WP+ G+PD S+ L F+ H ++R P++VHCS+G
Sbjct: 800 FNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFV----CHVRNKRAGKEEPVVVHCSAG 855
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQ 1455
+GRTG + A+ +E + L +VR MR QR M+Q RF EA+++ E+
Sbjct: 856 IGRTGVLITMETAMCLIECNQPVYPL-DIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE 914
>gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Homo
sapiens]
Length = 435
Score = 137 bits (346), Expect = 7e-32
Identities = 89/294 (30%), Positives = 143/294 (48%), Gaps = 9/294 (3%)
Query: 1195 WRELQDAQEHDARGRSIAIARCYSLKNR--HQDVMPYDSNRVVLRSGKDDYINASCVEGL 1252
W + H+A +A+ KNR ++DV P+D +R+ L +DYINAS ++ +
Sbjct: 16 WAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIK-M 74
Query: 1253 SPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMV 1312
+ TQ PLP T FW MV EQK +VML E K A+Y+P + + M+
Sbjct: 75 EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMI 134
Query: 1313 --HGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRF 1370
L L L S + R L L+ R ++H H+ TWP+ G+P+SP++ L F
Sbjct: 135 FEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF 194
Query: 1371 IQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAA--VQEVEAGNGIPELPQLVRRM 1428
+ +V P H P++VHCS+G+GR+G F L + + ++ +++ M
Sbjct: 195 LFKVRESG-SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEM 253
Query: 1429 RQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASIS-QKNHLP 1481
R+ R ++Q LRF Y AV+ + ++ V K L+ + H+P
Sbjct: 254 RKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIP 307
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 137 bits (346), Expect = 7e-32
Identities = 90/258 (34%), Positives = 139/258 (53%), Gaps = 10/258 (3%)
Query: 1206 ARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGL-SPYCPPLV 1260
++ + +A A + KNR+++V+PYD +RV L+ + DYINAS + GL SP +
Sbjct: 655 SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQ--EFI 712
Query: 1261 ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL 1320
ATQ PLP T DFW +V EQ+ +VML + E + K Y+P + QP HG L + L
Sbjct: 713 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLD-SQPCTHGHLRVTL 771
Query: 1321 SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH 1380
E R L L ++ S+ H+ WP+ G+P SP LL F + + +L
Sbjct: 772 VGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLR-QWLD 830
Query: 1381 QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL 1440
Q P IVHCS+GVGRTG L ++++++ G+ VR+MR+ R M+Q +
Sbjct: 831 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS-EGLLGPFSFVRKMRESRPLMVQTEA 889
Query: 1441 HLRFCYEAVVRHVEQVLQ 1458
F ++ ++R ++Q Q
Sbjct: 890 QYVFLHQCILRFLQQSAQ 907
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 137 bits (346), Expect = 7e-32
Identities = 90/258 (34%), Positives = 139/258 (53%), Gaps = 10/258 (3%)
Query: 1206 ARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKD----DYINASCVEGL-SPYCPPLV 1260
++ + +A A + KNR+++V+PYD +RV L+ + DYINAS + GL SP +
Sbjct: 833 SQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQ--EFI 890
Query: 1261 ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL 1320
ATQ PLP T DFW +V EQ+ +VML + E + K Y+P + QP HG L + L
Sbjct: 891 ATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLD-SQPCTHGHLRVTL 949
Query: 1321 SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH 1380
E R L L ++ S+ H+ WP+ G+P SP LL F + + +L
Sbjct: 950 VGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLR-QWLD 1008
Query: 1381 QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL 1440
Q P IVHCS+GVGRTG L ++++++ G+ VR+MR+ R M+Q +
Sbjct: 1009 QTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS-EGLLGPFSFVRKMRESRPLMVQTEA 1067
Query: 1441 HLRFCYEAVVRHVEQVLQ 1458
F ++ ++R ++Q Q
Sbjct: 1068 QYVFLHQCILRFLQQSAQ 1085
>gi|4506301 protein tyrosine phosphatase, non-receptor type 9 [Homo
sapiens]
Length = 593
Score = 135 bits (341), Expect = 2e-31
Identities = 90/251 (35%), Positives = 130/251 (51%), Gaps = 18/251 (7%)
Query: 1220 KNRHQDVMPYDSNRVVL--RSG--KDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ DV D RV L RSG + DYINAS ++G + TQ PL T DFWL
Sbjct: 330 KNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQK-NAYIGTQGPLENTYRDFWL 388
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
MV EQKV VIVM E ++K +Y+P E+ + G L++ V + + + L
Sbjct: 389 MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLE 448
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVH-----------AHYLHQRPL 1384
+ ++ KR + H F +WP+ G+P S ++L+ F++ V A Q P
Sbjct: 449 IHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCP- 507
Query: 1385 HTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRF 1444
PI+VHCS+G+GRTG F L + ++E G + Q V RMR QR +Q F
Sbjct: 508 EPPIVVHCSAGIGRTGTFCSLDICLAQLEE-LGTLNVFQTVSRMRTQRAFSIQTPEQYYF 566
Query: 1445 CYEAVVRHVEQ 1455
CY+A++ E+
Sbjct: 567 CYKAILEFAEK 577
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 134 bits (336), Expect = 9e-31
Identities = 84/235 (35%), Positives = 127/235 (54%), Gaps = 13/235 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVE---GLSPYCPPLVATQAPLPGTAADFWLM 1276
KNR+++++PYD+ RV L + YINAS ++ G + +A Q PLP T DFW M
Sbjct: 2245 KNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQM 2301
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ-PMVHGALSLALSSVRSTETHVERVLS 1335
+ EQK +VI M+ E E EK K RY+P G+ MV L LAL ++ + V R ++
Sbjct: 2302 IWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMT 2361
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
L+ R + HL+F WP+ P P +LL FI + ++H+ PII HCS+G
Sbjct: 2362 LEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS--YMRHIHR---SGPIITHCSAG 2416
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
+GR+G + + + ++ LVR MR QR M+Q + FCY+ ++
Sbjct: 2417 IGRSGTLICIDVVLGLISQDLDF-DISDLVRCMRLQRHGMVQTEDQYIFCYQVIL 2470
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 134 bits (336), Expect = 9e-31
Identities = 84/235 (35%), Positives = 127/235 (54%), Gaps = 13/235 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVE---GLSPYCPPLVATQAPLPGTAADFWLM 1276
KNR+++++PYD+ RV L + YINAS ++ G + +A Q PLP T DFW M
Sbjct: 2049 KNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQM 2105
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ-PMVHGALSLALSSVRSTETHVERVLS 1335
+ EQK +VI M+ E E EK K RY+P G+ MV L LAL ++ + V R ++
Sbjct: 2106 IWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMT 2165
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
L+ R + HL+F WP+ P P +LL FI + ++H+ PII HCS+G
Sbjct: 2166 LEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS--YMRHIHR---SGPIITHCSAG 2220
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
+GR+G + + + ++ LVR MR QR M+Q + FCY+ ++
Sbjct: 2221 IGRSGTLICIDVVLGLISQDLDF-DISDLVRCMRLQRHGMVQTEDQYIFCYQVIL 2274
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 134 bits (336), Expect = 9e-31
Identities = 84/235 (35%), Positives = 127/235 (54%), Gaps = 13/235 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVE---GLSPYCPPLVATQAPLPGTAADFWLM 1276
KNR+++++PYD+ RV L + YINAS ++ G + +A Q PLP T DFW M
Sbjct: 2240 KNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQM 2296
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ-PMVHGALSLALSSVRSTETHVERVLS 1335
+ EQK +VI M+ E E EK K RY+P G+ MV L LAL ++ + V R ++
Sbjct: 2297 IWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMT 2356
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
L+ R + HL+F WP+ P P +LL FI + ++H+ PII HCS+G
Sbjct: 2357 LEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS--YMRHIHR---SGPIITHCSAG 2411
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
+GR+G + + + ++ LVR MR QR M+Q + FCY+ ++
Sbjct: 2412 IGRSGTLICIDVVLGLISQDLDF-DISDLVRCMRLQRHGMVQTEDQYIFCYQVIL 2465
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 134 bits (336), Expect = 9e-31
Identities = 84/235 (35%), Positives = 127/235 (54%), Gaps = 13/235 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDDYINASCVE---GLSPYCPPLVATQAPLPGTAADFWLM 1276
KNR+++++PYD+ RV L + YINAS ++ G + +A Q PLP T DFW M
Sbjct: 2221 KNRYKNILPYDATRVPL-GDEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQM 2277
Query: 1277 VHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQ-PMVHGALSLALSSVRSTETHVERVLS 1335
+ EQK +VI M+ E E EK K RY+P G+ MV L LAL ++ + V R ++
Sbjct: 2278 IWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMT 2337
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
L+ R + HL+F WP+ P P +LL FI + ++H+ PII HCS+G
Sbjct: 2338 LEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS--YMRHIHR---SGPIITHCSAG 2392
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
+GR+G + + + ++ LVR MR QR M+Q + FCY+ ++
Sbjct: 2393 IGRSGTLICIDVVLGLISQDLDF-DISDLVRCMRLQRHGMVQTEDQYIFCYQVIL 2446
>gi|119120915 rhophilin 1 [Homo sapiens]
Length = 670
Score = 134 bits (336), Expect = 9e-31
Identities = 115/413 (27%), Positives = 187/413 (45%), Gaps = 62/413 (15%)
Query: 7 MPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVP-RDFEGC 65
+PMI L LKE + + +K+ + ++GE+ +Y E+++LE LRQ A+R P R+ G
Sbjct: 107 VPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALRQ-AMRTPSRNESGL 165
Query: 66 SVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALH 125
+L Y QL +L +R + + + W + +G + +E+ +L+N+GALH
Sbjct: 166 ELLTAYYNQLCFLDARF-LTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALH 224
Query: 126 SMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQA 185
+ +GA R EG + + FQ AAGAF+ LRE+F A S DMS L LM+ QA
Sbjct: 225 TQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQA 284
Query: 186 QECLLE-------KSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWK 238
QEC+ E + D +A+ +AQV Y+ R + P + W
Sbjct: 285 QECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDY---VPVSWT 341
Query: 239 KLVQMKIYYFAAVAHLHMG------------------------------------KQAEE 262
LV +K YF ++AH H+ ++ EE
Sbjct: 342 ALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEE 401
Query: 263 QQKFGERVAYFQSALDKLNEAIKL-----AKGQPDTVQDALRFTMDVIGGKYNSAKKDND 317
+++ G+ A+ + A+ EA++L + D ++ + T+ KY +++D
Sbjct: 402 RRQLGK--AHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDD 459
Query: 318 FIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASS 370
F EA A D +QP KP P GPDIF +L P++ A +
Sbjct: 460 FC--EAAEAPD-IQPKTHQ---KPEARMPRLSQGKGPDIFHRLGPLSVFSAKN 506
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 133 bits (335), Expect = 1e-30
Identities = 80/239 (33%), Positives = 130/239 (54%), Gaps = 10/239 (4%)
Query: 1220 KNRHQDVMPYDSNRVVL--RSGKD--DYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR ++PY+ NRV++ + G++ DY+NAS ++G +A+Q PL T DFW
Sbjct: 552 KNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWR 610
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ E K IVML E ++K A+Y+P++ + +G +++ L E++ R L
Sbjct: 611 MIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLL 668
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
+ ++ R + HF WPE+G+P ++ I V Q+ + PI VHCS+G
Sbjct: 669 VTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ--QQQSGNHPITVHCSAG 726
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE 1454
GRTG F L ++ V+A GI ++ Q V+ +R QR HM+Q FCY+ V +++
Sbjct: 727 AGRTGTFCALSTVLERVKA-EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Score = 119 bits (298), Expect = 2e-26
Identities = 75/242 (30%), Positives = 128/242 (52%), Gaps = 17/242 (7%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++PYD +RV L + DYINAS + G +A Q P T DFW
Sbjct: 259 KNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEK-NKFIAAQGPKEETVNDFWR 317
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ EQ + IVM+ + E ++ K A+Y+P + +G + +++ V + R
Sbjct: 318 MIWEQNTATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 1336 LQ----FRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHT-PIIV 1390
+Q ++ +R + HF +WP+ G+P +P +L+F+++V A P + I+V
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA----CNPQYAGAIVV 431
Query: 1391 HCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
HCS+GVGRTG F ++ A + + + ++ V R+R QR M+Q + F Y+A++
Sbjct: 432 HCSAGVGRTGTFVVIDAMLDMMHTERKV-DVYGFVSRIRAQRCQMVQTDMQYVFIYQALL 490
Query: 1451 RH 1452
H
Sbjct: 491 EH 492
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 133 bits (335), Expect = 1e-30
Identities = 80/239 (33%), Positives = 130/239 (54%), Gaps = 10/239 (4%)
Query: 1220 KNRHQDVMPYDSNRVVL--RSGKD--DYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR ++PY+ NRV++ + G++ DY+NAS ++G +A+Q PL T DFW
Sbjct: 561 KNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWR 619
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ E K IVML E ++K A+Y+P++ + +G +++ L E++ R L
Sbjct: 620 MIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLL 677
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
+ ++ R + HF WPE+G+P ++ I V Q+ + PI VHCS+G
Sbjct: 678 VTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ--QQQSGNHPITVHCSAG 735
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE 1454
GRTG F L ++ V+A GI ++ Q V+ +R QR HM+Q FCY+ V +++
Sbjct: 736 AGRTGTFCALSTVLERVKA-EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 793
Score = 119 bits (298), Expect = 2e-26
Identities = 75/242 (30%), Positives = 128/242 (52%), Gaps = 17/242 (7%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++PYD +RV L + DYINAS + G +A Q P T DFW
Sbjct: 268 KNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEK-NKFIAAQGPKEETVNDFWR 326
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ EQ + IVM+ + E ++ K A+Y+P + +G + +++ V + R
Sbjct: 327 MIWEQNTATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFC 384
Query: 1336 LQ----FRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHT-PIIV 1390
+Q ++ +R + HF +WP+ G+P +P +L+F+++V A P + I+V
Sbjct: 385 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA----CNPQYAGAIVV 440
Query: 1391 HCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
HCS+GVGRTG F ++ A + + + ++ V R+R QR M+Q + F Y+A++
Sbjct: 441 HCSAGVGRTGTFVVIDAMLDMMHTERKV-DVYGFVSRIRAQRCQMVQTDMQYVFIYQALL 499
Query: 1451 RH 1452
H
Sbjct: 500 EH 501
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
precursor [Homo sapiens]
Length = 793
Score = 133 bits (335), Expect = 1e-30
Identities = 80/239 (33%), Positives = 130/239 (54%), Gaps = 10/239 (4%)
Query: 1220 KNRHQDVMPYDSNRVVL--RSGKD--DYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR ++PY+ NRV++ + G++ DY+NAS ++G +A+Q PL T DFW
Sbjct: 552 KNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWR 610
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ E K IVML E ++K A+Y+P++ + +G +++ L E++ R L
Sbjct: 611 MIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLL 668
Query: 1336 LQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSG 1395
+ ++ R + HF WPE+G+P ++ I V Q+ + PI VHCS+G
Sbjct: 669 VTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ--QQQSGNHPITVHCSAG 726
Query: 1396 VGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVE 1454
GRTG F L ++ V+A GI ++ Q V+ +R QR HM+Q FCY+ V +++
Sbjct: 727 AGRTGTFCALSTVLERVKA-EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784
Score = 119 bits (298), Expect = 2e-26
Identities = 75/242 (30%), Positives = 128/242 (52%), Gaps = 17/242 (7%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++PYD +RV L + DYINAS + G +A Q P T DFW
Sbjct: 259 KNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEK-NKFIAAQGPKEETVNDFWR 317
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
M+ EQ + IVM+ + E ++ K A+Y+P + +G + +++ V + R
Sbjct: 318 MIWEQNTATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFC 375
Query: 1336 LQ----FRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHT-PIIV 1390
+Q ++ +R + HF +WP+ G+P +P +L+F+++V A P + I+V
Sbjct: 376 IQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA----CNPQYAGAIVV 431
Query: 1391 HCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVV 1450
HCS+GVGRTG F ++ A + + + ++ V R+R QR M+Q + F Y+A++
Sbjct: 432 HCSAGVGRTGTFVVIDAMLDMMHTERKV-DVYGFVSRIRAQRCQMVQTDMQYVFIYQALL 490
Query: 1451 RH 1452
H
Sbjct: 491 EH 492
>gi|196114951 protein tyrosine phosphatase, non-receptor type 12
isoform 1 [Homo sapiens]
Length = 780
Score = 133 bits (334), Expect = 2e-30
Identities = 106/349 (30%), Positives = 165/349 (47%), Gaps = 44/349 (12%)
Query: 1220 KNRHQDVMPYDSNRVVLR----SGKDDYINASCVEGLSPYCPPL-VATQAPLPGTAADFW 1274
KNR++D++P+D +RV L S DYINA+ ++G+ Y P VATQ PL T DFW
Sbjct: 61 KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGV--YGPKAYVATQGPLANTVIDFW 118
Query: 1275 LMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVL 1334
M+ E V +IVM E EM ++K RY+P P+ ++ ++ + R L
Sbjct: 119 RMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTL 178
Query: 1335 SLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSS 1394
L+F+++S R L H+ WP+ +P S ++L I + + H+ PI +HCS+
Sbjct: 179 LLEFQNES--RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHE---DVPICIHCSA 233
Query: 1395 GVGRTGAFALLYAAVQEVEAGNGIPE---LPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR 1451
G GRTGA + ++AG IPE + L++ MR QR +Q K + A+ +
Sbjct: 234 GCGRTGAICAIDYTWNLLKAGK-IPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQ 292
Query: 1452 HVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLV--LGGDVPISSIQATIAKLSIRP 1509
E+ LQ + + H Q D V + + +SSI+ K P
Sbjct: 293 LFEKQLQLYEI----------------HGAQKIADGVNEINTENMVSSIEP--EKQDSPP 334
Query: 1510 PGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQP 1558
P + + G A+ L P PE P+ PP+ +P P + P
Sbjct: 335 PKPPRTRSCLVEGDAKEEILQP---PEPHPV-----PPILTPSPPSAFP 375
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 132 bits (332), Expect = 3e-30
Identities = 137/429 (31%), Positives = 156/429 (36%), Gaps = 104/429 (24%)
Query: 716 PPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSP 775
PPP P P LP S A+ P + LPP PP P
Sbjct: 880 PPPLPGMTVPTLP----STAIPQPPPLQGTEMLPP---------------------PPPP 914
Query: 776 FPSSTGPGPHYLSG----PLPPGTYSGPTQLIQPRAPGPHAMPVAPGP---ALYPAPAYT 828
P + P P L G PLPP +G I P P P A P P A P P
Sbjct: 915 LPGAGIPPPPPLPGAGILPLPPLPGAG----IPPPPPLPGAAIPPPPPLPGAGIPLPPPL 970
Query: 829 PELGLVPRSS-PQHGVVSSPYV---GVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTV 884
P G+ P P G+ P + G+ P PP+ G PPP G +
Sbjct: 971 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP-------- 1022
Query: 885 DSIQAPIPSHTAPRPNPTPA---PPPPCFP---VPPPQPLPTPYTYPAGAKQPIPAQHHF 938
P+P P P P P PPPP P +PPP PLP AG P P
Sbjct: 1023 ----PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-----AGIPPPPPLP--- 1070
Query: 939 SSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPY 998
+GIP P P G P P P P P PP + + P PP +PP P
Sbjct: 1071 GAGIPPPPPLPGAGIPPPP---PLPGAGIPPPPPLPGVGIPPP---PPLPGAGIPPPPPL 1124
Query: 999 PYA------PQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPG---PPQPPHPPL 1049
P A P PG PPPPL P P PLP P P PG PP PP P +
Sbjct: 1125 PGAGIPPPPPLPGAGIPPPPPLPRVGIPPPP--PLPGAGIPPPPPLPGAGIPPPPPLPGV 1182
Query: 1050 AYGPAPSTRPMG-PQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPG----PGPVPPRPP-- 1102
P P +G P PL G +P P P PG P P PP PP
Sbjct: 1183 GIPPPPPLPGVGIPPPPPLPGAG-------------IPPPPPLPGMGIPPAPAPPLPPPG 1229
Query: 1103 -AAEPPPCL 1110
PPP L
Sbjct: 1230 TGIPPPPLL 1238
Score = 130 bits (327), Expect = 1e-29
Identities = 129/384 (33%), Positives = 147/384 (38%), Gaps = 64/384 (16%)
Query: 756 PRLPDTFLGSATP----LHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPH 811
P LP T S+ P + PP P P T P + P PP P Q + P P
Sbjct: 859 PPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPP-----PLQGTEMLPPPP- 912
Query: 812 AMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGP 871
P PG + P P P G++P + P G+ P PP+ G PPP G
Sbjct: 913 --PPLPGAGIPPPPPL-PGAGILP-------LPPLPGAGIPPPPPLPGAAIPPPPPLPGA 962
Query: 872 ELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPA---PPPPCFP---VPPPQPLPTPYTYP 925
+ + P P+P P P P P PPPP P +PPP PLP
Sbjct: 963 GIPLPP-PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG----- 1016
Query: 926 AGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPH------PQPHPSQAFG-PQPPQQPLPL 978
AG P P +GIP P P G P P P P P G P PP P
Sbjct: 1017 AGIPPPPPLP---GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1073
Query: 979 QHPHLFPPQAPGL-LPPQSPYPYA------PQPGVLGQPPPPLHTQLYPGPAQDPLPAHS 1031
P PP PG +PP P P A P PGV PPPPL P P PLP
Sbjct: 1074 IPP---PPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPP--PLPGAG 1128
Query: 1032 GALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHL-----VP 1086
P P PG PP PPL P P+ P P G P P +P
Sbjct: 1129 IPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIP---PPPPLPGAGIPPPPPLPGVGIP 1185
Query: 1087 SPAPSPGPG--PVPPRPPAAEPPP 1108
P P PG G P PP P A PPP
Sbjct: 1186 PPPPLPGVGIPPPPPLPGAGIPPP 1209
Score = 104 bits (260), Expect = 6e-22
Identities = 123/420 (29%), Positives = 142/420 (33%), Gaps = 112/420 (26%)
Query: 790 PLPPGTYSG--------------------------PTQLI----------------QPRA 807
P PPG SG PTQ I QP +
Sbjct: 768 PCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGS 827
Query: 808 PGPHAMPV-------------------APGPALYP---APAYTPELGLVPRSSPQ---HG 842
PH++ P P P + + P LG+VP P
Sbjct: 828 QPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMT 887
Query: 843 VVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQ-APIPSHTAPRPNP 901
V + P + PP+ G PPP P + P + P+P P P P
Sbjct: 888 VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPP 947
Query: 902 TPA----PPPPC----FPVPPPQP---LPTPYTYP-AGAKQPIPAQHHFSSGIPAGFPAP 949
P PPPP P+PPP P +P P P AG P P +GIP P P
Sbjct: 948 LPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLP---GAGIPPPPPLP 1004
Query: 950 RIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYA------PQ 1003
G P P P P P PP + P PP +PP P P A P
Sbjct: 1005 GAGIPP---PPPLPGAGIPPPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAGIPPPPPL 1058
Query: 1004 PGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPG---PPQPPHPPLAYGPAPSTRPM 1060
PG PPPPL P P PLP P P PG PP PP P + P P
Sbjct: 1059 PGAGIPPPPPLPGAGIPPP--PPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGA 1116
Query: 1061 G-PQAAPLTIRG----PSSAGQSTPSPHL-----VPSPAPSPGPG--PVPPRPPAAEPPP 1108
G P PL G P G P P +P P P PG G P PP P A PPP
Sbjct: 1117 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPP 1176
Score = 103 bits (258), Expect = 1e-21
Identities = 114/346 (32%), Positives = 130/346 (37%), Gaps = 71/346 (20%)
Query: 716 PPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSP 775
PPP P A PL P AG PP PP AG P G+ P PP P
Sbjct: 956 PPPLPGAGIPLPP-----PLPGAGIPPP-----PPLPGAGIPPPPPLPGAGIP---PPPP 1002
Query: 776 FPSSTGPGPHYLSG-------PLPPGTYSGPTQLIQPRAPGPHAMP---VAPGPAL---- 821
P + P P L G PLP P L P P +P + P P L
Sbjct: 1003 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1062
Query: 822 YPAPAYTPELGLVPRSS-PQHGVVSSPYV---GVGPAPPVAGLPSAPPPQFSG------P 871
P P P G+ P P G+ P + G+ P PP+ G+ PPP G P
Sbjct: 1063 IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPP 1122
Query: 872 ELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPA---PPPPCFP---VPPPQPLPTPYTYP 925
L A P P+P P P P P PPPP P +PPP PLP
Sbjct: 1123 PLPGAGIPPPP-------PLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPG----- 1170
Query: 926 AGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPH------PQPHPSQAFG-PQPPQQPLP- 977
AG P P GIP P P +G P P P P P G P P PLP
Sbjct: 1171 AGIPPPPPLP---GVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPP 1227
Query: 978 ----LQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLY 1019
+ P L P P LLP Q P P V G PPPL + L+
Sbjct: 1228 PGTGIPPPPLLPVSGPPLLP-QVGSSTLPTPQVCGFLPPPLPSGLF 1272
Score = 97.1 bits (240), Expect = 1e-19
Identities = 96/305 (31%), Positives = 113/305 (37%), Gaps = 59/305 (19%)
Query: 850 GVGPAPPVAGLPS---APPPQFSGP------ELAMAVRPATTTVDSIQAPIPSHTAPRPN 900
GV PPV GLP PP SGP E+++ V P +V + SH +
Sbjct: 753 GVLTLPPVDGLPGRPPCPPGAESGPQTKFCSEISLIVSPRRISVQ-----LDSHQPTQSI 807
Query: 901 PTPAPPPPCF--------PVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFP----- 947
P PPP PP + T + + + + S IP+ P
Sbjct: 808 SQPPPPPSLLWSAGQGQPGSQPPHSIST--EFQTSHEHSVSSAFKNSCNIPSPPPLPCTE 865
Query: 948 ----APRIGPQPQPHPQPHPSQAFGPQPP---QQPLPLQHPHLFPPQAPGL----LPPQS 996
P +G P P P P P P QP PLQ + PP P L +PP
Sbjct: 866 SSSSMPGLGMVPPP-PPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPP 924
Query: 997 PYPYA------PQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLA 1050
P P A P PG PPPPL P P PLP LP P PG PP PPL
Sbjct: 925 PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP--PPLPGAGIPLPPPLPGAGIPPPPPLP 982
Query: 1051 YGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHL-----VPSPAPSPGPG--PVPPRPPA 1103
P P+ P P G P P +P P P PG G P PP P A
Sbjct: 983 GAGIPPPPPLPGAGIP---PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1039
Query: 1104 AEPPP 1108
PPP
Sbjct: 1040 GIPPP 1044
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/117 (35%), Positives = 49/117 (41%), Gaps = 18/117 (15%)
Query: 1457 LQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESP 1516
L R G+PPP PL A I LP G +P + + I PP L P
Sbjct: 1146 LPRVGIPPP-PPLPGAGIPPPPPLP--------GAGIPPPP---PLPGVGIPPPPPL--P 1191
Query: 1517 VASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573
+P PP LP A +P P+P PP +P P P PP P P SGPP
Sbjct: 1192 GVGIP---PPPPLPGAGIPPPPPLPGMGIPPAPAP-PLPPPGTGIPPPPLLPVSGPP 1244
Score = 44.7 bits (104), Expect = 8e-04
Identities = 42/121 (34%), Positives = 52/121 (42%), Gaps = 13/121 (10%)
Query: 1461 GVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQAT--IAKLSIRPPGGLES--- 1515
G+PPP PL A+I LP + L +P + I + I PP L
Sbjct: 941 GIPPP-PPLPGAAIPPPPPLP--GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI 997
Query: 1516 -PVASLPGPA--EPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGP 1572
P LPG PP LP A +P P+P + PP PLP A P PP+P A P
Sbjct: 998 PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIP-PPPPLPGAGIPPP 1055
Query: 1573 P 1573
P
Sbjct: 1056 P 1056
Score = 43.9 bits (102), Expect = 0.001
Identities = 40/113 (35%), Positives = 48/113 (42%), Gaps = 19/113 (16%)
Query: 1461 GVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASL 1520
G+PPP PL A I LP G +P + I PP L P A +
Sbjct: 996 GIPPP-PPLPGAGIPPPPPLP--------GAGIPPPP---PLPGAGIPPPPPL--PGAGI 1041
Query: 1521 PGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573
P PP LP A +P P+P + PP PLP A P PP+P A PP
Sbjct: 1042 P---PPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIP-PPPPLPGAGIPPPP 1089
Score = 43.5 bits (101), Expect = 0.002
Identities = 38/125 (30%), Positives = 49/125 (39%), Gaps = 22/125 (17%)
Query: 1462 VPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQAT-------IAKLSIRPPGGLE 1514
+PPP PL A I LP G +P+ + + +I PP L
Sbjct: 908 LPPPPPPLPGAGIPPPPPLPG-------AGILPLPPLPGAGIPPPPPLPGAAIPPPPPLP 960
Query: 1515 SPVASLPGPAEPPGLPP------ASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAP 1568
LP P G+PP A +P P+P + PP PLP A P PP+P A
Sbjct: 961 GAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIP-PPPPLPGAG 1018
Query: 1569 SSGPP 1573
PP
Sbjct: 1019 IPPPP 1023
Score = 42.7 bits (99), Expect = 0.003
Identities = 40/119 (33%), Positives = 47/119 (39%), Gaps = 20/119 (16%)
Query: 1461 GVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLES----P 1516
G+PPP PL A I LP G +P + I PP L P
Sbjct: 1051 GIPPP-PPLPGAGIPPPPPLP--------GAGIPPPP---PLPGAGIPPPPPLPGAGIPP 1098
Query: 1517 VASLPGPA--EPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573
LPG PP LP A +P P+P + PP PLP A P PP+P PP
Sbjct: 1099 PPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIP-PPPPLPRVGIPPPP 1155
Score = 42.4 bits (98), Expect = 0.004
Identities = 39/113 (34%), Positives = 47/113 (41%), Gaps = 19/113 (16%)
Query: 1461 GVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASL 1520
G+PPP PL A I LP G +P + I PP L P A +
Sbjct: 1029 GIPPP-PPLPGAGIPPPPPLP--------GAGIPPPP---PLPGAGIPPPPPL--PGAGI 1074
Query: 1521 PGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573
P PP LP A +P P+P + PP PLP P PP+P A PP
Sbjct: 1075 P---PPPPLPGAGIPPPPPLPGAGIPP-PPPLPGVGIP-PPPPLPGAGIPPPP 1122
Score = 41.2 bits (95), Expect = 0.008
Identities = 40/133 (30%), Positives = 50/133 (37%), Gaps = 22/133 (16%)
Query: 1463 PPPCKPLASASISQKNHLPQDS--QDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASL 1520
PPP L SA Q P S + + +SS + PP +S+
Sbjct: 811 PPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSM 870
Query: 1521 PG----PAEPPGLPPASLP--ESTPIPSSSP-------PPLSSPLPEAPQPKEEP----- 1562
PG P PP LP ++P ST IP P PP PLP A P P
Sbjct: 871 PGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAG 930
Query: 1563 --PVPEAPSSGPP 1573
P+P P +G P
Sbjct: 931 ILPLPPLPGAGIP 943
Score = 40.8 bits (94), Expect = 0.011
Identities = 40/127 (31%), Positives = 51/127 (40%), Gaps = 19/127 (14%)
Query: 1462 VPPPCKPLASASISQKNHLPQDS--QDLVLGGDVPISSIQATIAKLSIRPPGGLES---- 1515
VPPP PL ++ LP + Q L G + + I PP L
Sbjct: 876 VPPPPPPLPGMTVPT---LPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGIL 932
Query: 1516 PVASLPGPA--EPPGLPPASLPESTPIPSSS---PPPLSS----PLPEAPQPKEEPPVPE 1566
P+ LPG PP LP A++P P+P + PPPL P P P PP P
Sbjct: 933 PLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPP-PP 991
Query: 1567 APSSGPP 1573
P +G P
Sbjct: 992 LPGAGIP 998
Score = 40.0 bits (92), Expect = 0.019
Identities = 38/119 (31%), Positives = 46/119 (38%), Gaps = 20/119 (16%)
Query: 1461 GVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASL 1520
G+PPP PL A I LP G +P + + I PP L
Sbjct: 1073 GIPPP-PPLPGAGIPPPPPLP--------GAGIPPPP---PLPGVGIPPPPPLPGAGIPP 1120
Query: 1521 PGPAEPPGLPP------ASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPP 1573
P P G+PP A +P P+P PP PLP A P PP+P A PP
Sbjct: 1121 PPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPP-PPPLPGAGIP-PPPPLPGAGIPPPP 1177
Score = 38.5 bits (88), Expect = 0.054
Identities = 74/304 (24%), Positives = 104/304 (34%), Gaps = 65/304 (21%)
Query: 674 EGRDFYADLESKVAALLERTQST-CQAREAARQQLLDRELKKKPPPRPTAPKP------- 725
E D +D++ + ++ Q Q ++ +QQ L + PP +P+P
Sbjct: 191 EQEDLLSDIQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLD 250
Query: 726 ---LLPRREESEAVEAGDPPEELRS---LPPDMVAGPRLPDTFLGSATPLHFPPSPFPSS 779
L P EA + D + L + LP + A PR P PPSP
Sbjct: 251 RFLLGPSGGAGEAPGSPDTEQALSALSDLPESLAAEPREPQQ----------PPSP---- 296
Query: 780 TGPGPHYLSGPLPPGTYSGPTQLIQPRAPG-PHAMPVA---PGPALYPAPAYTPELGLVP 835
G LP AP P A P A P +P P P G
Sbjct: 297 ---------GGLPVS-----------EAPSLPAAQPAAKDSPSSTAFPFPEAGP--GEEA 334
Query: 836 RSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELA--MAVRPATTTVDSIQAPIPS 893
+P G + G A P P + PE+ R + Q P
Sbjct: 335 AGAPVRGAGDTDEEGEEDA--FEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAP 392
Query: 894 HTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGP 953
A P +PAP CF P PL TP Y + + + +H S P +PRI
Sbjct: 393 AAASLPG-SPAPSQRCF---KPYPLITP-CYIKTTTRQLSSPNHSPSQSPN--QSPRIKR 445
Query: 954 QPQP 957
+P+P
Sbjct: 446 RPEP 449
Score = 36.2 bits (82), Expect = 0.27
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 29/179 (16%)
Query: 1399 TGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQ 1458
+G+ +Y+ E + + ++ Q +R +QQ Q++L L+ ++ +Q Q
Sbjct: 177 SGSDTDIYSFHSATEQEDLLSDIQQAIRLQQQQ-----QQQLQLQ------LQQQQQQQQ 225
Query: 1459 RHGVPPPCKPLASASISQKNHLPQDSQDLVLG-----GDVPIS-SIQATIAKLSIRPPGG 1512
G P P + S L D +LG G+ P S + ++ LS P
Sbjct: 226 LQGAEEPAAPPTAVSPQPGAFLGLDR--FLLGPSGGAGEAPGSPDTEQALSALSDLP--- 280
Query: 1513 LESPVASLPGPAEPP---GLPPA---SLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVP 1565
ES A P +PP GLP + SLP + P SP + P PEA +E P
Sbjct: 281 -ESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAP 338
Score = 35.0 bits (79), Expect = 0.60
Identities = 48/202 (23%), Positives = 68/202 (33%), Gaps = 51/202 (25%)
Query: 964 SQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPA 1023
S A P+ PQQP P GL ++P A QP P + +P P
Sbjct: 282 SLAAEPREPQQP----------PSPGGLPVSEAPSLPAAQPAAKDSPS----STAFPFPE 327
Query: 1024 QDPLPAHSGA-------------------LPFPSPGPPQPPH----PPLAYGPAPSTRPM 1060
P +GA P SPG P P G P
Sbjct: 328 AGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQ 387
Query: 1061 GPQA-APLTIRGPSSAGQSTPSPHLVPSP-----------APSPGPGPVPPRPPAAE--P 1106
GP A A ++ G + Q P+ + +P +P+ P P + P + P
Sbjct: 388 GPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKRRP 447
Query: 1107 PPCLRRGAAAADLLSSSPESQH 1128
P L RG+ A ++P +H
Sbjct: 448 EPSLSRGSRTALASVAAPAKKH 469
Score = 35.0 bits (79), Expect = 0.60
Identities = 22/55 (40%), Positives = 27/55 (49%), Gaps = 4/55 (7%)
Query: 1523 PAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSL 1577
P PP LP A +P P+P + PL PLP A P PP P ++ PP L
Sbjct: 909 PPPPPPLPGAGIPPPPPLPGAGILPLP-PLPGAGIP---PPPPLPGAAIPPPPPL 959
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 131 bits (329), Expect = 6e-30
Identities = 81/240 (33%), Positives = 132/240 (55%), Gaps = 12/240 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++PYD+ RV L + DD YINAS + G + + + TQ PLPGT DFW
Sbjct: 1948 KNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG-NNFRREYIVTQGPLPGTKDDFWK 2006
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
MV EQ V IVM+ E + K Y+P ++ + +G L L + S R
Sbjct: 2007 MVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ-DSLYYGDLILQMLSESVLPEWTIREFK 2065
Query: 1336 LQFRDQ-SLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSS 1394
+ +Q R + H H+ WP+ G+P++ +L++F++ V Y+++ P P +VHCS+
Sbjct: 2066 ICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVR-DYINRSPGAGPTVVHCSA 2124
Query: 1395 GVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQ---EKLHLRFCYEAVVR 1451
GVGRTG F L +Q++++ + + ++ V +R R HM+Q + ++L C V+R
Sbjct: 2125 GVGRTGTFIALDRILQQLDSKDSV-DIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR 2183
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 131 bits (329), Expect = 6e-30
Identities = 81/240 (33%), Positives = 132/240 (55%), Gaps = 12/240 (5%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGKDD----YINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++PYD+ RV L + DD YINAS + G + + + TQ PLPGT DFW
Sbjct: 1730 KNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPG-NNFRREYIVTQGPLPGTKDDFWK 1788
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
MV EQ V IVM+ E + K Y+P ++ + +G L L + S R
Sbjct: 1789 MVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ-DSLYYGDLILQMLSESVLPEWTIREFK 1847
Query: 1336 LQFRDQ-SLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSS 1394
+ +Q R + H H+ WP+ G+P++ +L++F++ V Y+++ P P +VHCS+
Sbjct: 1848 ICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVR-DYINRSPGAGPTVVHCSA 1906
Query: 1395 GVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQ---EKLHLRFCYEAVVR 1451
GVGRTG F L +Q++++ + + ++ V +R R HM+Q + ++L C V+R
Sbjct: 1907 GVGRTGTFIALDRILQQLDSKDSV-DIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR 1965
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 131 bits (329), Expect = 6e-30
Identities = 86/239 (35%), Positives = 124/239 (51%), Gaps = 15/239 (6%)
Query: 1220 KNRHQDVMPYDSNRVVL--RSGKD--DYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
K R ++PYD NRV+L + G++ DYINAS ++G +ATQ PL T DFW
Sbjct: 454 KARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQK-DYFIATQGPLAHTVEDFWR 512
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSL-----ALSSVRSTETHV 1330
M+ E K IVML E E+ K +Y+PTE + HG +++ LS S +
Sbjct: 513 MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGS--VTHGEITIEIKNDTLSEAISIRDFL 570
Query: 1331 ERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIV 1390
+ Q R + R + HF WPE+G+P ++ I V Q+ + PI V
Sbjct: 571 VTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQ--QQQTGNHPITV 628
Query: 1391 HCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAV 1449
HCS+G GRTG F L ++ V+A G+ ++ Q V+ +R QR HM+Q FCY+ V
Sbjct: 629 HCSAGAGRTGTFIALSNILERVKA-EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV 686
Score = 122 bits (305), Expect = 4e-27
Identities = 77/241 (31%), Positives = 129/241 (53%), Gaps = 16/241 (6%)
Query: 1220 KNRHQDVMPYDSNRVVLRSGK----DDYINASCVEGLSPYCPPLVATQAPLPGTAADFWL 1275
KNR+ +++P D +RV+L DYINAS ++G +A Q P T DFW
Sbjct: 162 KNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEK-NKFIAAQGPKQETVNDFWR 220
Query: 1276 MVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLS 1335
MV EQK + IVML + E +++K +Y+P + +G + + + + R
Sbjct: 221 MVWEQKSATIVMLTNLKERKEEKCHQYWPDQ--GCWTYGNIRVCVEDCVVLVDYTIRKFC 278
Query: 1336 LQFR---DQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHT-PIIVH 1391
+Q + R + LHF +WP+ G+P +P +L+F+++V P+H PI+VH
Sbjct: 279 IQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT----LNPVHAGPIVVH 334
Query: 1392 CSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVR 1451
CS+GVGRTG F ++ A + + A + ++ + V R+R QR M+Q + F Y+A++
Sbjct: 335 CSAGVGRTGTFIVIDAMMAMMHAEQKV-DVFEFVSRIRNQRPQMVQTDMQYTFIYQALLE 393
Query: 1452 H 1452
+
Sbjct: 394 Y 394
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,878,812
Number of Sequences: 37866
Number of extensions: 6261866
Number of successful extensions: 141036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 960
Number of HSP's successfully gapped in prelim test: 2817
Number of HSP's that attempted gapping in prelim test: 36088
Number of HSP's gapped (non-prelim): 48472
length of query: 1636
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1520
effective length of database: 13,855,062
effective search space: 21059694240
effective search space used: 21059694240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.