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Search of human proteins with 24307967
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
(1099 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 2194 0.0
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 2106 0.0
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 1466 0.0
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 1229 0.0
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 1103 0.0
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 803 0.0
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 117 8e-26
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 114 5e-25
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 113 9e-25
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 113 9e-25
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 113 9e-25
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 111 3e-24
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 110 1e-23
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 110 1e-23
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 107 5e-23
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 107 5e-23
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 100 8e-21
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 100 8e-21
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 100 8e-21
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 100 1e-20
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 99 2e-20
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 99 2e-20
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens] 98 4e-20
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi... 98 4e-20
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi... 97 8e-20
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens] 96 2e-19
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi... 96 2e-19
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi... 96 2e-19
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 94 5e-19
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 94 5e-19
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 2194 bits (5685), Expect = 0.0
Identities = 1099/1099 (100%), Positives = 1099/1099 (100%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
Sbjct: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
Query: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
Sbjct: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
Query: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
Sbjct: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
Query: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
Sbjct: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
Query: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP 480
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP
Sbjct: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP 480
Query: 481 PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI 540
PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI
Sbjct: 481 PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI 540
Query: 541 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 600
FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL
Sbjct: 541 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 600
Query: 601 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
Sbjct: 601 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
Query: 661 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 720
PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH
Sbjct: 661 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 720
Query: 721 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 780
SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED
Sbjct: 721 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 780
Query: 781 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 840
WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE
Sbjct: 781 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 840
Query: 841 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 900
HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP
Sbjct: 841 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 900
Query: 901 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 960
LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL
Sbjct: 901 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 960
Query: 961 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 1020
AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD
Sbjct: 961 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 1020
Query: 1021 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1080
PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA
Sbjct: 1021 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1080
Query: 1081 VTPTEKMFPNSSADKSGTM 1099
VTPTEKMFPNSSADKSGTM
Sbjct: 1081 VTPTEKMFPNSSADKSGTM 1099
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 2106 bits (5457), Expect = 0.0
Identities = 1067/1099 (97%), Positives = 1070/1099 (97%), Gaps = 24/1099 (2%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
Sbjct: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
Query: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
Sbjct: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
Query: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
Sbjct: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
Query: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
Sbjct: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
Query: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP 480
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR
Sbjct: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG 480
Query: 481 PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI 540
++ R R +DSGQAIPLVVESCIRYINLYGLQQQGI
Sbjct: 481 -------RRNARTRN-----------------QDSGQAIPLVVESCIRYINLYGLQQQGI 516
Query: 541 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 600
FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL
Sbjct: 517 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 576
Query: 601 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
Sbjct: 577 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 636
Query: 661 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 720
PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH
Sbjct: 637 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 696
Query: 721 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 780
SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED
Sbjct: 697 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 756
Query: 781 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 840
WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE
Sbjct: 757 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 816
Query: 841 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 900
HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP
Sbjct: 817 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 876
Query: 901 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 960
LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL
Sbjct: 877 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 936
Query: 961 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 1020
AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD
Sbjct: 937 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 996
Query: 1021 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1080
PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA
Sbjct: 997 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1056
Query: 1081 VTPTEKMFPNSSADKSGTM 1099
VTPTEKMFPNSSADKSGTM
Sbjct: 1057 VTPTEKMFPNSSADKSGTM 1075
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 1466 bits (3796), Expect = 0.0
Identities = 753/1095 (68%), Positives = 891/1095 (81%), Gaps = 23/1095 (2%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MS+ ++FKKDKEIIAEYE+Q+KEIR QLVEQ KCLEQQ+E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDI 119
EYSR+LEKLAERF +K RS+++HQ +KKDQ LLSPVNCWYL+L+Q RRES+DHATL+DI
Sbjct: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
Query: 120 FMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAES 179
++NNVI+R QISED R+FKKSKEI Q+HE+L+KV NELYTVMKTYHMYHAESISAES
Sbjct: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
Query: 180 KLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKA 239
KLKEAEKQEEKQ +SGD ++ R E+R QRRSSVKKIEKMKEKRQAKYSENKLK KA
Sbjct: 181 KLKEAEKQEEKQIGRSGDPVFHI-RLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKA 239
Query: 240 RNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGL 299
RN+YLL L ATNA++ KYYIHD+SDLIDCCDLG+HASL R RTYLSAEYNLETSRHEGL
Sbjct: 240 RNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGL 299
Query: 300 DVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRY 359
D+IENAVDNL+ RSDK M+M FCPP+KFEFQ HMGDEVCQVSAQQPVQ EL++RY
Sbjct: 300 DIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRY 359
Query: 360 HQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETY 419
QLQSRLATLKIENEEV+KT +AT+QT+QDM+T+ED+DVS+ FQHSRSTESVKS SETY
Sbjct: 360 QQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETY 419
Query: 420 MSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR 479
+SK +IAKRRANQQETE FYF K +EY+ GSNLITKLQAKHDLL++TLGEG RAE TTR
Sbjct: 420 LSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTR 479
Query: 480 PPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQG 539
PP +PPKPQK R+ RP S Y+ KLFNG +E F+KDSGQ IPL+VESCIR+INLYGLQ QG
Sbjct: 480 PPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
Query: 540 IFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQD 599
IFRV GSQVEVNDIKNSFERGE+PL DDQ+ DINSVAGVLKLYFRGLENPLFPKERF D
Sbjct: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFND 599
Query: 600 LISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
LIS I+++N ER I+++L+TLPR V++VMRYLFAFLNHLSQYSDENMMDPYNLAICF
Sbjct: 600 LISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
Query: 660 GPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSP 719
GPTLM +P+ QD VSCQAH+NE+IKTIIIHHE IFP +EL+GPVYEKCMA G++YCDSP
Sbjct: 660 GPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMA-GDDYCDSP 718
Query: 720 HSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASE 779
+SE G ++EVD D GTEPHTS++E E IEAIAKFDY+GRS RELSFKKGASLLLYHRASE
Sbjct: 719 YSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASE 778
Query: 780 DWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT 839
DWWEGRHNG+DGL+PHQYIVVQDMDD FSD+LSQKADSEASSGP+ +DK+SSK D+ SPT
Sbjct: 779 DWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSK-DMNSPT 837
Query: 840 EHISDYGFGGVMGRVRLRSDGAAIPRRRSG--GDTH---SPPRGL-GPSIDTPPRAAACP 893
+ D G + R R R + P RR G D H PP L S+D + A
Sbjct: 838 DRHPD----GYLARQRKRGEPPP-PVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLA-- 890
Query: 894 SSPHKIPLTRG-RIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDH 952
S P + RG +SPE+RR GS +I+ D + +R + S +++ DH
Sbjct: 891 SHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDH 950
Query: 953 KSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP-VSSEPAS 1011
K L+ E +A+DIE+TM+TAL+ELRELERQ+T K APDVVLDTLE +KN P P S+E S
Sbjct: 951 KPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLS 1010
Query: 1012 PLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSS 1071
PLH + +R + +RRS+SSS++ M+TFKP ++ R+ G QL+PP +RP +P V + ++
Sbjct: 1011 PLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRM-GVQLKPPALRP-KPAVLPK--TN 1066
Query: 1072 SSSGVGSPAVTPTEK 1086
+ G P PT+K
Sbjct: 1067 PTIGPAPPPQGPTDK 1081
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 1229 bits (3181), Expect = 0.0
Identities = 644/1103 (58%), Positives = 822/1103 (74%), Gaps = 53/1103 (4%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIR 528
E +R +C R + +R+ +DS QAIPLVVESCIR
Sbjct: 480 ESQRTDCSLAR------RSSTVRK--------------------QDSSQAIPLVVESCIR 513
Query: 529 YINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLE 588
+I+ +GLQ +GIFRV GSQVEVNDIKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE
Sbjct: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
Query: 589 NPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDEN 648
+PLFPK+ F DL++ + ++N ER I+++L+ LP+ +++MRYLFAFLNHLSQ+S+EN
Sbjct: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
Query: 649 MMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKC 708
MMDPYNLAICFGP+LM +P+G D VSCQAH+NE+IKTIII HE IFPSPRELEGPVY +
Sbjct: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR- 692
Query: 709 MAGG--EEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFK 766
GG E+YCDSPH E ++++ D E HTSD+E E IEAIAKFDY+GR+ RELSFK
Sbjct: 693 --GGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFK 750
Query: 767 KGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLD 826
KGASLLLY RAS+DWWEGRHNG+DGLIPHQYIVVQD +D + S K++ E S P +
Sbjct: 751 KGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PE 809
Query: 827 DKASSKNDLQSPT-EHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDT 885
+K +++ P+ H++D + + R R + +I R+ D+H L S +
Sbjct: 810 EKVTARAGASCPSGGHVADIYLANI-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SS 866
Query: 886 PPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGST 944
P A+C S I E P+K ++ GS SI+ + K + +R T +
Sbjct: 867 PGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAG 926
Query: 945 RHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP 1004
R S +H+ ++ E +A+DIE TM++AL+ELRELERQ++VK PDVVLDTLEPLK P
Sbjct: 927 RSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVV 986
Query: 1005 V-SSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPV 1063
+SEP+SPLHT +++DP+ A +RS+S++ ++ F+P S ++A A ++PP RP +P
Sbjct: 987 APTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPT 1044
Query: 1064 VQHRSSSSSSSGVGSPAVTPTEK 1086
V +++++S S + T+K
Sbjct: 1045 VFPKTNATSPGVNSSTSPQSTDK 1067
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 1103 bits (2852), Expect = 0.0
Identities = 557/859 (64%), Positives = 683/859 (79%), Gaps = 46/859 (5%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIR 528
E +R +C R + +R+ +DS QAIPLVVESCIR
Sbjct: 480 ESQRTDCSLAR------RSSTVRK--------------------QDSSQAIPLVVESCIR 513
Query: 529 YINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLE 588
+I+ +GLQ +GIFRV GSQVEVNDIKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE
Sbjct: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
Query: 589 NPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDEN 648
+PLFPK+ F DL++ + ++N ER I+++L+ LP+ +++MRYLFAFLNHLSQ+S+EN
Sbjct: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
Query: 649 MMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKC 708
MMDPYNLAICFGP+LM +P+G D VSCQAH+NE+IKTIII HE IFPSPRELEGPVY +
Sbjct: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR- 692
Query: 709 MAGG--EEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFK 766
GG E+YCDSPH E ++++ D E HTSD+E E IEAIAKFDY+GR+ RELSFK
Sbjct: 693 --GGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFK 750
Query: 767 KGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLD 826
KGASLLLY RAS+DWWEGRHNG+DGLIPHQYIVVQD +D + S K++ E S P +
Sbjct: 751 KGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PE 809
Query: 827 DKASSKNDLQSPT-EHISD 844
+K +++ P+ H++D
Sbjct: 810 EKVTARAGASCPSGGHVAD 828
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 803 bits (2074), Expect = 0.0
Identities = 411/806 (50%), Positives = 569/806 (70%), Gaps = 10/806 (1%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M++ K ++++ + AEYE Q+KE+R QL EQ +CLE Q E R +LLQ+L EF RR+AE+E
Sbjct: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
Query: 61 LEYSRSLEKLAERFSSK---IRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATL 116
LEYSR LEKLAERFSS+ + SSREHQ F+K+ LLSP++CW ++L TR++SR+ A L
Sbjct: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
Query: 117 NDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESIS 176
+++ + RLS I+EDV RL KKS+++ Q+ +ELL+V +EL T KTY YH ES++
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
Query: 177 AESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKC 236
AE+KL+EAE+QEEK+ +S + E P R+SS+KK ++ EKRQAK+ E+KLKC
Sbjct: 181 AEAKLREAERQEEKRAGRSVPTT-TAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKC 239
Query: 237 TKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRH 296
TKARN+YLL+LA+ NAA+S YY+HDV DL+DCCD GFH +L + R+Y +AE + S+
Sbjct: 240 TKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQV 299
Query: 297 EGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELL 356
+GL +E AV+ LD DK V+++ VFCPPL+F++ PH GDEV ++ + ++ E+L
Sbjct: 300 QGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEIL 359
Query: 357 MRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAAS 416
R +QSRL IE EEV KTL AT+Q L +++ +D DV D+FQ S STES+KS +S
Sbjct: 360 PRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSS 419
Query: 417 ETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECG 476
+ +RR QQETE FY TK +EY++G +++ KLQAKH+ L++ L G++ E
Sbjct: 420 DP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQE 477
Query: 477 TTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQ 536
+ K QK R+PRP S Y+ +LF G ME FI+ SGQ +PLVVESCIR+INL GLQ
Sbjct: 478 VSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQ 537
Query: 537 QQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKER 596
+GIFRV G+Q+ V++I+++FERGEDPLV+ D++SVAGVLKLYFR LE PLFP +
Sbjct: 538 HEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDL 597
Query: 597 FQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLA 656
F +L+++ +LE AERV + ++L LP V+VV+RYLF FLNHL+QYSDENMMDPYNLA
Sbjct: 598 FGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLA 657
Query: 657 ICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYC 716
+CFGPTL+ +P GQDPV+ Q +N++++T+I+ + +FP L GPVYEKCMA C
Sbjct: 658 VCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASC 717
Query: 717 --DSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLY 774
D+ GA +E + + P D+ +EA+A F Y GR+ +ELSF++G L L+
Sbjct: 718 LGDAQLESLGADNEPELE-AEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
Query: 775 HRASEDWWEGRHNGVDGLIPHQYIVV 800
RAS DWW G HNG+ GLIPH+YI +
Sbjct: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 117 bits (292), Expect = 8e-26
Identities = 80/271 (29%), Positives = 135/271 (49%), Gaps = 30/271 (11%)
Query: 520 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 579
PL+VE C+ +I GL ++G+FR+PG V D+++SF+ GE PL D + D+++VA +
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFD--STTDVHTVASL 230
Query: 580 LKLYFRGLENPLFPKERFQDLISTIKL--ENPAERVHQIQQILVTLPRVVIVVMRYLFAF 637
LKLY R L P+ P R++D +S +L ++ E ++ + + LP+ ++RY+ F
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKF 290
Query: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 694
L+ + YS+ N M NLA FGP ++ P +DPV+ + + ++ +I H +F
Sbjct: 291 LDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIMEGTSLVQHLMTVLIRKHSQLF 349
Query: 695 PSPRELEGPVYEK----CMA--GGEEYCDSPHSEPG---------------AIDEVDHDN 733
+P EGP + C G EE EPG A+ +
Sbjct: 350 TAPVP-EGPTSPRGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLDGAAVAVLSRTA 408
Query: 734 GTEPHTSDEEVEQIEAIAKFDYMGRSPRELS 764
T P + ++++ + + R PR LS
Sbjct: 409 PTGPGSRCSPGKKVQTLPSWKSSFRQPRSLS 439
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 114 bits (285), Expect = 5e-25
Identities = 63/209 (30%), Positives = 117/209 (55%), Gaps = 7/209 (3%)
Query: 517 QAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL-VDDQNERDINS 575
Q +PL+V +C R + GL+ GI+RVPG+ V+ ++ RG + + D+ +D+N
Sbjct: 823 QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNV 882
Query: 576 VAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLF 635
++ +LK +FR L PLF +++ D I ++E+ ER+ +++++ LP +++L
Sbjct: 883 ISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLV 942
Query: 636 AFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAI 693
L ++ +S++N M+P NLA+ FGPTL+ + D V+ ++++T+I H +
Sbjct: 943 GHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWF 1002
Query: 694 FPSPRELEGPVYEKCMAGGEEYCDSPHSE 722
F S E +G E+ G +E P+ E
Sbjct: 1003 F-SDEEDKG---ERTPVGDKEPQAVPNIE 1027
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 113 bits (283), Expect = 9e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 520 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 579
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 58 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 115
Query: 580 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 637
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 116 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 175
Query: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 694
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 176 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 234
Query: 695 PSPRELE 701
P EL+
Sbjct: 235 PKDAELQ 241
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 113 bits (283), Expect = 9e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 520 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 579
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 60 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 117
Query: 580 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 637
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 118 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 177
Query: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 694
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 178 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 236
Query: 695 PSPRELE 701
P EL+
Sbjct: 237 PKDAELQ 243
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 113 bits (283), Expect = 9e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 520 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 579
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 153 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 210
Query: 580 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 637
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 211 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 270
Query: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 694
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 271 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 329
Query: 695 PSPRELE 701
P EL+
Sbjct: 330 PKDAELQ 336
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 111 bits (278), Expect = 3e-24
Identities = 56/179 (31%), Positives = 104/179 (58%), Gaps = 3/179 (1%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERG-EDPLVDDQNERDINSVA 577
IPL+V+ C + + GL+ GI+RVPG+ ++ ++ +G D + D RD+N ++
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
Query: 578 GVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAF 637
+LK +FR L PLF +++ D I + E+P +R+ +++++ LP +++L A
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
Query: 638 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAIF 694
L +++ S++N M+P NLAI FGPTL+ + V+ ++++T+I HH+ F
Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF 1339
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 110 bits (274), Expect = 1e-23
Identities = 61/182 (33%), Positives = 97/182 (53%), Gaps = 5/182 (2%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-G 560
K+++ + +K P+VV+ CIR I GL +G++RV G + D+K +F+R G
Sbjct: 264 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 323
Query: 561 EDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQIL 620
E + DIN + G LKLYFR L PL + + I + K+ +P E++ + + L
Sbjct: 324 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 383
Query: 621 VTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHIN 680
LP +RYL A L ++ + EN+M+ NL I FGPTLM P+ + A +N
Sbjct: 384 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALN 439
Query: 681 EV 682
++
Sbjct: 440 DI 441
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 110 bits (274), Expect = 1e-23
Identities = 61/182 (33%), Positives = 97/182 (53%), Gaps = 5/182 (2%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-G 560
K+++ + +K P+VV+ CIR I GL +G++RV G + D+K +F+R G
Sbjct: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
Query: 561 EDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQIL 620
E + DIN + G LKLYFR L PL + + I + K+ +P E++ + + L
Sbjct: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
Query: 621 VTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHIN 680
LP +RYL A L ++ + EN+M+ NL I FGPTLM P+ + A +N
Sbjct: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALN 413
Query: 681 EV 682
++
Sbjct: 414 DI 415
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 107 bits (268), Expect = 5e-23
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 2/194 (1%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-G 560
K++ + +K P+VV+ CIR I GL+ +G++RV G + D+K +F+R G
Sbjct: 273 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 332
Query: 561 EDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQIL 620
E + DIN + G LKLYFR L P+ + + I K+ N ER+ + ++L
Sbjct: 333 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 392
Query: 621 VTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC-QAHI 679
+ LP +RYL L ++ +N M+ NL I FGPTLM P+ +
Sbjct: 393 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 452
Query: 680 NEVIKTIIIHHEAI 693
++I I+I +E +
Sbjct: 453 QKLIVQILIENEDV 466
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 107 bits (268), Expect = 5e-23
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 2/194 (1%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-G 560
K++ + +K P+VV+ CIR I GL+ +G++RV G + D+K +F+R G
Sbjct: 137 KVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDG 196
Query: 561 EDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQIL 620
E + DIN + G LKLYFR L P+ + + I K+ N ER+ + ++L
Sbjct: 197 EKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVL 256
Query: 621 VTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC-QAHI 679
+ LP +RYL L ++ +N M+ NL I FGPTLM P+ +
Sbjct: 257 MLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRY 316
Query: 680 NEVIKTIIIHHEAI 693
++I I+I +E +
Sbjct: 317 QKLIVQILIENEDV 330
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 100 bits (249), Expect = 8e-21
Identities = 65/223 (29%), Positives = 109/223 (48%), Gaps = 10/223 (4%)
Query: 477 TTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQA--IPLVVESCIRYINLYG 534
T + P PKP R P P ++ F S++ + + + IP+V+ + Y+ +
Sbjct: 220 TQKSPATAPKPMPPRPPLP-----NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHA 274
Query: 535 LQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPK 594
L +GIFR + V +++ + G D NE + +V +LK + R L PL
Sbjct: 275 LTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAV--ILKTFLRELPEPLLTF 332
Query: 595 ERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYN 654
+ + ++ + ++ ++RV Q+L TLP V+R+L AFL +S +SD+N M N
Sbjct: 333 DLYPHVVGFLNIDE-SQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTN 391
Query: 655 LAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSP 697
LA+ FGP L+ D + IN K ++ H +FPSP
Sbjct: 392 LAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSP 434
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 100 bits (249), Expect = 8e-21
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGE 561
++F ++ A + +P V+ CIR + GL G++R+ G+ + ++ + E
Sbjct: 325 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDE 384
Query: 562 DPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILV 621
+DD D++ + G LKL+FR L PLFP F+ I+ IKL++ A R ++ ++
Sbjct: 385 RLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVR 444
Query: 622 TLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM--HIPDGQDPVSCQAHI 679
+LP +R LF L + ++ ++N M ++AI FGPTL+ + + P++
Sbjct: 445 SLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMT-MVFQ 503
Query: 680 NEVIKTIIIHHEAIFP 695
N+V++ I+ IFP
Sbjct: 504 NQVVELILQQCADIFP 519
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 100 bits (249), Expect = 8e-21
Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 3/196 (1%)
Query: 502 KLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGE 561
++F ++ A + +P V+ CIR + GL G++R+ G+ + ++ + E
Sbjct: 352 QVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDE 411
Query: 562 DPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILV 621
+DD D++ + G LKL+FR L PLFP F+ I+ IKL++ A R ++ ++
Sbjct: 412 RLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVR 471
Query: 622 TLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM--HIPDGQDPVSCQAHI 679
+LP +R LF L + ++ ++N M ++AI FGPTL+ + + P++
Sbjct: 472 SLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMT-MVFQ 530
Query: 680 NEVIKTIIIHHEAIFP 695
N+V++ I+ IFP
Sbjct: 531 NQVVELILQQCADIFP 546
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 100 bits (248), Expect = 1e-20
Identities = 58/185 (31%), Positives = 98/185 (52%), Gaps = 6/185 (3%)
Query: 486 KPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPG 545
KP+ RP + G + + IP+ +E CI YI GL +GI+RV G
Sbjct: 1228 KPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLSTEGIYRVSG 1287
Query: 546 SQVEVNDIKNSFERGEDPLVDDQNERD--INSVAGVLKLYFRGLENPLFPKERFQDLIST 603
++ E+ ++ F++ + D E+D +N+VAG +K +F L +PL P DL+
Sbjct: 1288 NKSEMESLQRQFDQDHNL---DLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEA 1344
Query: 604 IKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTL 663
K+ + +++H ++++L P+ V +Y+ + LN +S + N+M NL+ICF PTL
Sbjct: 1345 HKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTL 1404
Query: 664 MHIPD 668
M PD
Sbjct: 1405 MR-PD 1408
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 10/175 (5%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
IPL VE C+ +I GL +G++RV G++ + ++I+ F++ + + E +N+VAG
Sbjct: 1274 IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSM-EVTVNAVAG 1332
Query: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
LK +F L +PL P +L+ K+ + ER+H +++I+ V V RY+ L
Sbjct: 1333 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1392
Query: 639 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAI 693
N +SQ N+M NL+ICF PTLM PD ++ E + T IH +
Sbjct: 1393 NRVSQQHKINLMTADNLSICFWPTLMR-PDFEN--------REFLSTTKIHQSVV 1438
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 10/175 (5%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
IPL VE C+ +I GL +G++RV G++ + ++I+ F++ + + E +N+VAG
Sbjct: 1273 IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSM-EVTVNAVAG 1331
Query: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
LK +F L +PL P +L+ K+ + ER+H +++I+ V V RY+ L
Sbjct: 1332 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1391
Query: 639 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAI 693
N +SQ N+M NL+ICF PTLM PD ++ E + T IH +
Sbjct: 1392 NRVSQQHKINLMTADNLSICFWPTLMR-PDFEN--------REFLSTTKIHQSVV 1437
>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
Length = 771
Score = 98.2 bits (243), Expect = 4e-20
Identities = 111/437 (25%), Positives = 183/437 (41%), Gaps = 64/437 (14%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 264
Query: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 265 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 323
Query: 639 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 681
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 324 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 383
Query: 682 ---VIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCD-------SPHSEPGAI-DEVD 730
V++ +I ++EA+F P +L+ V + + D S S P + EV
Sbjct: 384 IIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVS 443
Query: 731 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 790
G ++D I+ +D SP + + L + A+ E +
Sbjct: 444 FSVGGRHSSTDSNKASSGDISPYD--NNSP---VLSERSLLAMQEDAAPGGSEKLYR--- 495
Query: 791 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSK---------NDLQSPTEH 841
+P Q+++V LS E+S GP L S + + L+S ++
Sbjct: 496 --VPGQFMLV--------GHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSK- 544
Query: 842 ISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSP--PRGLGPSIDTPPRAAACPSSPHKI 899
D G G G + S A P S G+ SP PR G + +
Sbjct: 545 --DPGMTGSSGDIFESSSLRAGPCSLSQGNL-SPNWPRWQGSPAELDSDTQGARRTQAAA 601
Query: 900 PLTRGRIESPEKRRMAT 916
P T GR R +T
Sbjct: 602 PATEGRAHPAVSRACST 618
>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
sapiens]
Length = 974
Score = 98.2 bits (243), Expect = 4e-20
Identities = 111/437 (25%), Positives = 183/437 (41%), Gaps = 64/437 (14%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 410 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 467
Query: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 468 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 526
Query: 639 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 681
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 527 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 586
Query: 682 ---VIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCD-------SPHSEPGAI-DEVD 730
V++ +I ++EA+F P +L+ V + + D S S P + EV
Sbjct: 587 IIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVS 646
Query: 731 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 790
G ++D I+ +D SP + + L + A+ E +
Sbjct: 647 FSVGGRHSSTDSNKASSGDISPYD--NNSP---VLSERSLLAMQEDAAPGGSEKLYR--- 698
Query: 791 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSK---------NDLQSPTEH 841
+P Q+++V LS E+S GP L S + + L+S ++
Sbjct: 699 --VPGQFMLV--------GHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSK- 747
Query: 842 ISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSP--PRGLGPSIDTPPRAAACPSSPHKI 899
D G G G + S A P S G+ SP PR G + +
Sbjct: 748 --DPGMTGSSGDIFESSSLRAGPCSLSQGNL-SPNWPRWQGSPAELDSDTQGARRTQAAA 804
Query: 900 PLTRGRIESPEKRRMAT 916
P T GR R +T
Sbjct: 805 PATEGRAHPAVSRACST 821
>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
sapiens]
Length = 765
Score = 97.1 bits (240), Expect = 8e-20
Identities = 63/206 (30%), Positives = 108/206 (52%), Gaps = 23/206 (11%)
Query: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 410 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 467
Query: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 468 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 526
Query: 639 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 681
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 527 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 586
Query: 682 ---VIKTIIIHHEAIFPSPRELEGPV 704
V++ +I ++EA+F P +L+ V
Sbjct: 587 IIAVVQKMIENYEALFMVPPDLQNEV 612
>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
Length = 555
Score = 95.9 bits (237), Expect = 2e-19
Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 21/262 (8%)
Query: 439 YFTKFKEYVNGSNLITKLQA-KHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLS 497
Y ++ E++ L+ + ++D Q+L EG T PP P P R P P
Sbjct: 263 YLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGR------TPPPTKTPPP---RPPLPTQ 313
Query: 498 VYSHKLFNGSMEAFIKDS--GQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKN 555
+ L ++KD G+ IP V+ + Y+ GL+ +G+FR S V +I+
Sbjct: 314 QFGVSL------QYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQR 367
Query: 556 SFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQ 615
+ +G+ DD DI+ A +LK + R L PL + ++ ++ +E+ RV
Sbjct: 368 LYNQGKPVNFDDYG--DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTG 424
Query: 616 IQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC 675
+QIL +LP VV+RYL FL+ +S+ S N M+ NLA FG L+ G +S
Sbjct: 425 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA 484
Query: 676 QAHINEVIKTIIIHHEAIFPSP 697
+N + +I ++E IF +P
Sbjct: 485 LVPLNMFTELLIEYYEKIFSTP 506
>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
sapiens]
Length = 433
Score = 95.9 bits (237), Expect = 2e-19
Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 21/262 (8%)
Query: 439 YFTKFKEYVNGSNLITKLQA-KHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLS 497
Y ++ E++ L+ + ++D Q+L EG T PP P P R P P
Sbjct: 141 YLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGR------TPPPTKTPPP---RPPLPTQ 191
Query: 498 VYSHKLFNGSMEAFIKDS--GQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKN 555
+ L ++KD G+ IP V+ + Y+ GL+ +G+FR S V +I+
Sbjct: 192 QFGVSL------QYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQR 245
Query: 556 SFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQ 615
+ +G+ DD DI+ A +LK + R L PL + ++ ++ +E+ RV
Sbjct: 246 LYNQGKPVNFDDYG--DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTG 302
Query: 616 IQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC 675
+QIL +LP VV+RYL FL+ +S+ S N M+ NLA FG L+ G +S
Sbjct: 303 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA 362
Query: 676 QAHINEVIKTIIIHHEAIFPSP 697
+N + +I ++E IF +P
Sbjct: 363 LVPLNMFTELLIEYYEKIFSTP 384
>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
sapiens]
Length = 464
Score = 95.9 bits (237), Expect = 2e-19
Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 21/262 (8%)
Query: 439 YFTKFKEYVNGSNLITKLQA-KHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLS 497
Y ++ E++ L+ + ++D Q+L EG T PP P P R P P
Sbjct: 172 YLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGR------TPPPTKTPPP---RPPLPTQ 222
Query: 498 VYSHKLFNGSMEAFIKDS--GQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKN 555
+ L ++KD G+ IP V+ + Y+ GL+ +G+FR S V +I+
Sbjct: 223 QFGVSL------QYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQR 276
Query: 556 SFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQ 615
+ +G+ DD DI+ A +LK + R L PL + ++ ++ +E+ RV
Sbjct: 277 LYNQGKPVNFDDYG--DIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTG 333
Query: 616 IQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC 675
+QIL +LP VV+RYL FL+ +S+ S N M+ NLA FG L+ G +S
Sbjct: 334 CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSA 393
Query: 676 QAHINEVIKTIIIHHEAIFPSP 697
+N + +I ++E IF +P
Sbjct: 394 LVPLNMFTELLIEYYEKIFSTP 415
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 94.4 bits (233), Expect = 5e-19
Identities = 48/162 (29%), Positives = 83/162 (51%)
Query: 503 LFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGED 562
+F + K +P +V C+ I G+++ GI+RV G ++ +K +F+
Sbjct: 1007 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1066
Query: 563 PLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVT 622
+ +E D+N++AG LKLYFR L PLF E + + I L +P + + +L++
Sbjct: 1067 DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLS 1126
Query: 623 LPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM 664
LP ++ +L L +++ N M +NLA FGPTL+
Sbjct: 1127 LPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1168
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 94.4 bits (233), Expect = 5e-19
Identities = 48/162 (29%), Positives = 83/162 (51%)
Query: 503 LFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGED 562
+F + K +P +V C+ I G+++ GI+RV G ++ +K +F+
Sbjct: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
Query: 563 PLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVT 622
+ +E D+N++AG LKLYFR L PLF E + + I L +P + + +L++
Sbjct: 1111 DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLS 1170
Query: 623 LPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM 664
LP ++ +L L +++ N M +NLA FGPTL+
Sbjct: 1171 LPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,218,299
Number of Sequences: 37866
Number of extensions: 2047802
Number of successful extensions: 12015
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 390
Number of HSP's that attempted gapping in prelim test: 10467
Number of HSP's gapped (non-prelim): 1833
length of query: 1099
length of database: 18,247,518
effective HSP length: 113
effective length of query: 986
effective length of database: 13,968,660
effective search space: 13773098760
effective search space used: 13773098760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.