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Search of human proteins with 242247257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo
sapiens]
(1118 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 2189 0.0
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 2184 0.0
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 2163 0.0
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 998 0.0
gi|38570149 WWC family member 3 [Homo sapiens] 706 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 89 3e-17
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 89 3e-17
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 89 3e-17
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 86 2e-16
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 86 3e-16
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 86 3e-16
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 76 2e-13
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 73 1e-12
gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo sap... 70 1e-11
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 69 2e-11
gi|114520609 neural precursor cell expressed, developmentally do... 69 2e-11
gi|114520607 neural precursor cell expressed, developmentally do... 69 2e-11
gi|222352183 neural precursor cell expressed, developmentally do... 67 7e-11
gi|21361472 neural precursor cell expressed, developmentally dow... 67 7e-11
gi|222352094 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352092 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352090 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352088 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352086 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352084 neural precursor cell expressed, developmentally do... 67 7e-11
gi|222352082 neural precursor cell expressed, developmentally do... 67 7e-11
gi|239047795 pleckstrin homology domain containing, family A mem... 64 8e-10
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 62 2e-09
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 62 2e-09
gi|11141889 WW45 protein [Homo sapiens] 62 4e-09
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 2189 bits (5671), Expect = 0.0
Identities = 1118/1118 (100%), Positives = 1118/1118 (100%)
Query: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE
Sbjct: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
Query: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR
Sbjct: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
Query: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH
Sbjct: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
Query: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK
Sbjct: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
Query: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE
Sbjct: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
Query: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR
Sbjct: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
Query: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH
Sbjct: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
Query: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK
Sbjct: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
Query: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL
Sbjct: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
Query: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ
Sbjct: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
Query: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT
Sbjct: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
Query: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA
Sbjct: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
Query: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW
Sbjct: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
Query: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED
Sbjct: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
Query: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP
Sbjct: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
Query: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR
Sbjct: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
Query: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE
Sbjct: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
Query: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVH 1080
LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVH
Sbjct: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVH 1080
Query: 1081 RLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
RLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
Sbjct: 1081 RLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 2184 bits (5659), Expect = 0.0
Identities = 1118/1119 (99%), Positives = 1118/1119 (99%), Gaps = 1/1119 (0%)
Query: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE
Sbjct: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
Query: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR
Sbjct: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
Query: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH
Sbjct: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
Query: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK
Sbjct: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
Query: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE
Sbjct: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
Query: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR
Sbjct: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
Query: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH
Sbjct: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
Query: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK
Sbjct: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
Query: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL
Sbjct: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
Query: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ
Sbjct: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
Query: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT
Sbjct: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
Query: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA
Sbjct: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
Query: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW
Sbjct: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
Query: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED
Sbjct: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
Query: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP
Sbjct: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
Query: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR
Sbjct: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
Query: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE
Sbjct: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
Query: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR-MDRAEHKGELQTDKMMRAAAKDV 1079
LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR MDRAEHKGELQTDKMMRAAAKDV
Sbjct: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV 1080
Query: 1080 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
Sbjct: 1081 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1119
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 2163 bits (5605), Expect = 0.0
Identities = 1112/1119 (99%), Positives = 1112/1119 (99%), Gaps = 7/1119 (0%)
Query: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE
Sbjct: 1 MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWE 60
Query: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR
Sbjct: 61 EAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
Query: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH
Sbjct: 121 LELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVH 180
Query: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK
Sbjct: 181 LQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK 240
Query: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE
Sbjct: 241 SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAE 300
Query: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR
Sbjct: 301 KVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPR 360
Query: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH
Sbjct: 361 KWTQGEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLH 420
Query: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK
Sbjct: 421 SQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSK 480
Query: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL
Sbjct: 481 VEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSL 540
Query: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ
Sbjct: 541 SSPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQ 600
Query: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT
Sbjct: 601 LGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGAT 660
Query: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA
Sbjct: 661 RIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDA 720
Query: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW
Sbjct: 721 SDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRW 780
Query: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED
Sbjct: 781 YNLLSYKYLKKQSRELKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLED 840
Query: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP
Sbjct: 841 SWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSP 900
Query: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR
Sbjct: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
Query: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
NSLERRSVRMKR PSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE
Sbjct: 961 NSLERRSVRMKR------PSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1014
Query: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR-MDRAEHKGELQTDKMMRAAAKDV 1079
LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR MDRAEHKGELQTDKMMRAAAKDV
Sbjct: 1015 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDV 1074
Query: 1080 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
Sbjct: 1075 HRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1113
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 998 bits (2579), Expect = 0.0
Identities = 584/1189 (49%), Positives = 767/1189 (64%), Gaps = 80/1189 (6%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
+LPLP GWEEARD+DGKV+YIDH R TSWIDPRDR TKPL+FADC+ DELP GWE +D
Sbjct: 9 QLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFD 68
Query: 65 PQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELA 124
PQ+G Y+IDH KTTQIEDPR QWR EQE MLKDYL VAQ+AL QKE+Y VK+QRL LA
Sbjct: 69 PQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALA 128
Query: 125 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE 184
EY +L+ ++ K S SL SGSSSS+KYDP+ILKAEI+T + RV KLKRE+ ++ E
Sbjct: 129 LDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQE 188
Query: 185 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM 244
L +KE+GF+TL++IDKKMS Q Y+L EA+A+L E K+I+KAI+ GEKEKQDL++SLA
Sbjct: 189 LLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAK 248
Query: 245 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL 304
L++ F D+ S +S L +Q LD SQT ISG G+ S + LAEKVRL
Sbjct: 249 LQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRL 308
Query: 305 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ 364
L+YEEAKR +ANLKI+L+KLDSEAWPG LD E+++L+LINEKEELLKE++F++P+K TQ
Sbjct: 309 SLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQ 368
Query: 365 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK 424
E+E+LE R+RLE++L + R T S+AL ERL+L +R +L+++LEE T+ LHSQLK
Sbjct: 369 DELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLK 428
Query: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYY-DPFEQLDSELQSKVEF 483
SLS+S S+SSGSS GSL SSRGSL SS S S S T+LYY +Q+D + Q K++F
Sbjct: 429 SLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDF 488
Query: 484 LLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRS--------LSGTPKSMTSLS 535
LL E +G+ PSG ITTIHE+EV K+ G L + + L+ PKS+ SLS
Sbjct: 489 LLQE-KSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLS 547
Query: 536 PRSSLSSPSPPCSPLMAD---PLLAG-DAFLN--SLEFEDPELSATLCELSL-------- 581
RSSLSS SPP SPL+ + P+ + DA L+ + +FED ELS+ ++SL
Sbjct: 548 SRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLD 607
Query: 582 ------GNSAQERYRLEEPGTEGKQLGQA--------VNTAQGCGLKVACVSAAVSDESV 627
S E L E E G A G K CVSAAVSDESV
Sbjct: 608 SDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESV 667
Query: 628 AGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSA 687
AGDSGVYEA V++ E + ++ V ++QI L+Y+ K+ F ++I QL NL A
Sbjct: 668 AGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHA 727
Query: 688 LLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVD 747
L KV RVAVLP S +CLFRT+ +++++FN+VF V++S AL QKTLRVD
Sbjct: 728 FLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVD 787
Query: 748 VCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPAS- 806
+C+ + EECL G QISLA++ S E T WYNLL K + + E V P
Sbjct: 788 LCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQP 847
Query: 807 --GPASTDAVSALLEQTAVEL----------EKRQEGRSSTQTLEDSWRYEETSENEAVA 854
DAVSALL +T+ EL E+ + G+ + + W ++ +
Sbjct: 848 LVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIV 907
Query: 855 EEEEEEV---EEEEGEEDVFTEKASPDM--DG------------------YPALKVDKET 891
E+E EV E+ ED+ + + P+M DG P L VDKET
Sbjct: 908 AEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL-VDKET 966
Query: 892 NTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSST 951
NT+ A VRPK+R + Q PF+R S I+RS+TFSPG ++QY+CRLNRSDSDSST
Sbjct: 967 NTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSST 1026
Query: 952 LSKKPPFVRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQL 1011
L+KK FVRNS ERRS+R+KR S ++ E +RTSLDLELDLQA+ T S+L
Sbjct: 1027 LAKKSLFVRNSTERRSLRVKR---TVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRL 1083
Query: 1012 TQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRMDRA--EHKGELQTD 1069
E+ L++L+++LE+ K+ GE +LP + EDERF+ LL+ EK+ +++ E K L +
Sbjct: 1084 NDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAE 1143
Query: 1070 KMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
K+MR +KDV RLR QS K P +VQSFREK+A+FTR +++IP+L ADDV
Sbjct: 1144 KLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
>gi|38570149 WWC family member 3 [Homo sapiens]
Length = 1092
Score = 706 bits (1822), Expect = 0.0
Identities = 468/1120 (41%), Positives = 653/1120 (58%), Gaps = 101/1120 (9%)
Query: 72 IDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQL 131
+DH K TQIEDPR QWRREQE MLK+YL+VAQEAL+A+KEIYQ+KQQR ELAQ+EYQQL
Sbjct: 1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQL 60
Query: 132 HAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERG 191
H + E S S SG S+++KYDP +KAEIA+ + R+++LKRE+ ++ ELQ+KE+G
Sbjct: 61 HKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKG 120
Query: 192 FQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRT 251
+TL++ID+KMS SYKLDEAQA++ E + IKKAI GEKE++DL+ SLA L D F+
Sbjct: 121 VETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKN 180
Query: 252 DRGSHSDLWSSSSSL-ESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEE 310
L + +P+Q+ D SQTDI G F + +L ++VRL +YEE
Sbjct: 181 SCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEE 240
Query: 311 AKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQL 370
A++R+AN++ QLA+LD+E+WP +++RDRL LI EKE LL+E++ I ++ + G+V +L
Sbjct: 241 ARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARL 300
Query: 371 EMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSM 430
E R+RLE++L+ AR T ++ TER+ L KRN L+ +LEEATR + L SQLKSL +S
Sbjct: 301 EEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCAST 360
Query: 431 QSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDP-FEQLDSELQSKVEFLLLEGA 489
++SSGSS GSL SSRGSL ASS S +S SFTD+Y P +E+ D+E + F L+
Sbjct: 361 LTVSSGSSRGSLASSRGSL-ASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIP-- 417
Query: 490 TGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSP 549
++ D A + G R TP+S+ SLS RSSLSS SPP SP
Sbjct: 418 --------FDSLGRD--APFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLSPPSSP 467
Query: 550 LMADPLLAG-DAFLNSL--EFEDPELSA---------TLCELSL--------------GN 583
L L A D+ L L E P L A + + L G
Sbjct: 468 LDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGDEDLPGMAALQPHGVPGDGE 527
Query: 584 SAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGA 643
ER G + ++A+ + +SA +SD S+A DSGV+E +R
Sbjct: 528 GPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLTKRNED 587
Query: 644 SEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVL 703
+E A+ S G +I + L D ++ + ++QL N + L ++D KV+IRV +
Sbjct: 588 AEEPAYGDTASN--GDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDCKVHIRVYLP 645
Query: 704 PCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGA 763
P T + ++ L+ LVFNEVF + + AL K+L++ VC+ EE LG A
Sbjct: 646 PLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEELLGIA 705
Query: 764 QISLAEVCRSGERSTRWYNLLSYKYLK-KQSRELKPVGVMAPASGPA-------STDAVS 815
QI+LA+ E RW+++ + + ++RE G + A PA TDAV+
Sbjct: 706 QINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAG-ESSARDPAHTISISGKTDAVT 764
Query: 816 ALLEQT-----AVELEKRQEGRSSTQTLEDSWRYEETSEN-EAVAEEEEEEVEEEEGEED 869
LL +T AVE E +E T E+ E E EA++E + + G +
Sbjct: 765 VLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSN 824
Query: 870 V----------------------FTEKA---SPDMDGYPALKVDKETNTE----TPAPSP 900
F +A SP+ LKVDKETNTE A S
Sbjct: 825 CTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASL 884
Query: 901 TVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVR 960
RP R G+ PF+R TI+RS+TFSPG +SQYVCRL RSDSDSSTL +K PFVR
Sbjct: 885 VKERPSRRARGS----PFVRSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVR 940
Query: 961 NSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKE 1020
N+LERR++R K+ S +S +E + RTSLDLELDLQA+RT QL +E+ L+E
Sbjct: 941 NTLERRTLRYKQ--------SCRSSLAELMARTSLDLELDLQASRTRQRQLNEELCALRE 992
Query: 1021 LKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEK--RMDRAEHKGELQTDKMMRAAAKD 1078
L+++LE A+ G+ +LP W+ DER R LLR E+ R + +++ E +KM++ A+K+
Sbjct: 993 LRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDYRHEQAAEKMLKKASKE 1052
Query: 1079 VHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
+++LRGQS KEP +VQ+FREK+AFFTRPR+NIP L ADDV
Sbjct: 1053 IYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV 1092
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 88.6 bits (218), Expect = 3e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
Query: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
Query: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Query: 171 VNKLKREMVHLQHELQFKERGF 192
++LK + +H +L+ RGF
Sbjct: 463 PSELKGKFIHT--KLRKSSRGF 482
Score = 38.9 bits (89), Expect = 0.028
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 88.6 bits (218), Expect = 3e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
Query: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
Query: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Query: 171 VNKLKREMVHLQHELQFKERGF 192
++LK + +H +L+ RGF
Sbjct: 463 PSELKGKFIHT--KLRKSSRGF 482
Score = 38.9 bits (89), Expect = 0.028
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 88.6 bits (218), Expect = 3e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
Query: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
Query: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Query: 171 VNKLKREMVHLQHELQFKERGF 192
++LK + +H +L+ RGF
Sbjct: 463 PSELKGKFIHT--KLRKSSRGF 482
Score = 38.9 bits (89), Expect = 0.028
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 85.9 bits (211), Expect = 2e-16
Identities = 41/90 (45%), Positives = 59/90 (65%), Gaps = 4/90 (4%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR-DRYTKPLTFADCISDELPLGWEEAYDP 65
PLP+ WE A G+VY+IDH +TTSW+DPR + KP +C +ELP GWE+ DP
Sbjct: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPP--EECKENELPYGWEKIDDP 360
Query: 66 QVGDYFIDHNTKTTQIEDPRVQWRRE-QEH 94
G Y++DH + TQ E+P ++ +R+ Q+H
Sbjct: 361 IYGTYYVDHINRRTQFENPVLEAKRKLQQH 390
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/34 (58%), Positives = 22/34 (64%)
Query: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
D LP WE AY + YFIDHNTKTT DPR+
Sbjct: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRL 335
Score = 33.5 bits (75), Expect = 1.2
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
E LP GWE+ D YY+DH NR T + +P
Sbjct: 347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENP 379
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 85.5 bits (210), Expect = 3e-16
Identities = 38/87 (43%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
PLP+ WE A G +Y+IDH +TT+W+DPR K DC ELP GWE+ DPQ
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 67 VGDYFIDHNTKTTQIEDPRVQWRREQE 93
G Y++DH + TQ E+P + +R+++
Sbjct: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQ 379
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/58 (43%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 29 NRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
N+T S +D R+ + T + LP WE AY YFIDHNTKTT DPR+
Sbjct: 274 NQTNSSMDFRNYMMRDETL-----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 85.5 bits (210), Expect = 3e-16
Identities = 38/87 (43%), Positives = 54/87 (62%), Gaps = 1/87 (1%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
PLP+ WE A G +Y+IDH +TT+W+DPR K DC ELP GWE+ DPQ
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 67 VGDYFIDHNTKTTQIEDPRVQWRREQE 93
G Y++DH + TQ E+P + +R+++
Sbjct: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQ 379
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/58 (43%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 29 NRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRV 86
N+T S +D R+ + T + LP WE AY YFIDHNTKTT DPR+
Sbjct: 274 NQTNSSMDFRNYMMRDETL-----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 76.3 bits (186), Expect = 2e-13
Identities = 37/79 (46%), Positives = 47/79 (59%), Gaps = 8/79 (10%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
PLP GWE+ +D +G+VYY++H RTT W DPR T LP GWE Y +
Sbjct: 406 PLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPR-------TQGMIQEPALPPGWEMKYTSE 457
Query: 67 VGDYFIDHNTKTTQIEDPR 85
YF+DHNT+TT +DPR
Sbjct: 458 GVRYFVDHNTRTTTFKDPR 476
Score = 69.7 bits (169), Expect = 1e-11
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 48/150 (32%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
LP GWE+ +G+VYY+DH +TT+W P LP GWE+ DP+
Sbjct: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERP-----------------LPPGWEKRTDPRG 344
Query: 68 GDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQE 127
Y++DHNT+TT W+R +++Y E +Q ++ +L+ A Q
Sbjct: 345 RFYYVDHNTRTT-------TWQRPTAEYVRNY------------EQWQSQRNQLQGAMQH 385
Query: 128 YQQLHAVWEHKLGSQVSLVSGSSSSSKYDP 157
+ SQ L SS+S+ +DP
Sbjct: 386 F------------SQRFLYQSSSASTDHDP 403
Score = 64.3 bits (155), Expect = 6e-10
Identities = 39/111 (35%), Positives = 51/111 (45%), Gaps = 29/111 (26%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKP-------------------- 44
E PLP GWE+ D G+ YY+DH RTT+W P Y +
Sbjct: 329 ERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQ 388
Query: 45 --LTFADCISDE------LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
L + S + LP GWE+ D Y+++HNT+TTQ EDPR Q
Sbjct: 389 RFLYQSSSASTDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQ 438
Score = 38.1 bits (87), Expect = 0.047
Identities = 16/34 (47%), Positives = 21/34 (61%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
E LP GWE +G Y++DH RTT++ DPR
Sbjct: 443 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 476
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 73.2 bits (178), Expect = 1e-12
Identities = 34/82 (41%), Positives = 47/82 (57%), Gaps = 7/82 (8%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAY 63
P PLP GWE+ D +VY+++H +TT W DPR + + + LP GWE Y
Sbjct: 454 PYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQN-------EEPLPEGWEIRY 506
Query: 64 DPQVGDYFIDHNTKTTQIEDPR 85
+ YF+DHNT+TT +DPR
Sbjct: 507 TREGVRYFVDHNTRTTTFKDPR 528
Score = 71.2 bits (173), Expect = 5e-12
Identities = 43/158 (27%), Positives = 72/158 (45%), Gaps = 32/158 (20%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
LP GWE+ +D G+ YY+DH RTT+W P+ LP GWE D +
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ---------------PLPPGWERRVDDRR 395
Query: 68 GDYFIDHNTKTTQIEDPRV-------QWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQR 120
Y++DHNT+TT + P + QW+ ++ + Q A+ + Y
Sbjct: 396 RVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQL--------QGAMQQFNQRYLYSASM 447
Query: 121 LELAQQEYQQLHAVWEHKLGS--QVSLVSGSSSSSKYD 156
L Y L WE ++ S +V V+ ++ +++++
Sbjct: 448 LAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWE 485
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/119 (36%), Positives = 54/119 (45%), Gaps = 29/119 (24%)
Query: 3 RPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP------------------------- 37
RP+ PLP GWE D +VYY+DH RTT+W P
Sbjct: 379 RPQ-PLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQF 437
Query: 38 RDRYTKPLTFADCISDE---LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQE 93
RY + +D LP GWE+ D YF++HNTKTTQ EDPR Q + +E
Sbjct: 438 NQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE 496
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 5/109 (4%)
Query: 52 SDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPR---VQWRREQEHMLKDYLVVAQEALS 108
++ LP GWE+ DP Y++DHNT+TT E P+ W R + + Y V +
Sbjct: 348 TETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTT 407
Query: 109 AQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP 157
+ + E Q + QL + +Q L S S +++ DP
Sbjct: 408 TWQRPTMESVRNFEQWQSQRNQLQGAMQQ--FNQRYLYSASMLAAENDP 454
Score = 43.9 bits (102), Expect = 9e-04
Identities = 22/59 (37%), Positives = 32/59 (54%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAY 63
E PLPEGWE +G Y++DH RTT++ DPR+ + I+ E W+ A+
Sbjct: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAH 553
>gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
sapiens]
Length = 504
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 23/185 (12%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRD------RYTKPLT------FADCIS 52
++PLP GWE A+ G+ Y+++H ++TT+W DPR T P + + S
Sbjct: 170 DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS 229
Query: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQE------- 105
LP GWE+A Y+I+H KTT DPR+ R + V Q
Sbjct: 230 GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQS 289
Query: 106 ---ALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEI-LK 161
+ Q +Q RL+ Q E ++L + L + ++ S+++S E+ L+
Sbjct: 290 PQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALR 349
Query: 162 AEIAT 166
+++ T
Sbjct: 350 SQLPT 354
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 69.3 bits (168), Expect = 2e-11
Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 7/79 (8%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQ 66
PLP GWE+ D +G+VY+++H R T W DPR + LP GWE +
Sbjct: 398 PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ-------GQLNEKPLPEGWEMRFTVD 450
Query: 67 VGDYFIDHNTKTTQIEDPR 85
YF+DHN +TT DPR
Sbjct: 451 GIPYFVDHNRRTTTYIDPR 469
Score = 67.0 bits (162), Expect = 9e-11
Identities = 43/156 (27%), Positives = 68/156 (43%), Gaps = 41/156 (26%)
Query: 2 PRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEE 61
P + PLP GWE+ D G+VYY+DH + T+W P + LP GWE
Sbjct: 281 PVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP---------------EPLPPGWER 325
Query: 62 AYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRL 121
D Y++DH T+TT W+R +++Y E +Q+++ +L
Sbjct: 326 RVDNMGRIYYVDHFTRTT-------TWQRPTLESVRNY------------EQWQLQRSQL 366
Query: 122 ELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP 157
+ A Q++ Q L +S S ++DP
Sbjct: 367 QGAMQQFNQRFIYGNQDL-------FATSQSKEFDP 395
Score = 66.2 bits (160), Expect = 2e-10
Identities = 44/118 (37%), Positives = 52/118 (44%), Gaps = 34/118 (28%)
Query: 3 RPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP------------------------- 37
RPE PLP GWE D G++YY+DH RTT+W P
Sbjct: 315 RPE-PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQF 373
Query: 38 --RDRYTKPLTFADCISDE------LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
R Y FA S E LP GWE+ D YF++HNT+ TQ EDPR Q
Sbjct: 374 NQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ 431
Score = 48.5 bits (114), Expect = 3e-05
Identities = 20/34 (58%), Positives = 24/34 (70%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
E PLPEGWE DG Y++DH RTT++IDPR
Sbjct: 436 EKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 68.9 bits (167), Expect = 2e-11
Identities = 41/106 (38%), Positives = 52/106 (49%), Gaps = 26/106 (24%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDR---YTKPLTFAD---------CISDE- 54
LP GWEE +D G+ YY+DH +RTT+W P + T LT + SD
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 55 -------------LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
LP GWE + P +FIDHNTKTT EDPR++
Sbjct: 410 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLK 455
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/85 (40%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR---DRYTKPLTFADCISD--ELPLGWEEA 62
LP+GWE +G+ ++IDH +TT+W DPR + + T D +D LP GWEE
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQ 87
++I+HN K TQ EDPR++
Sbjct: 483 THTDGRIFYINHNIKRTQWEDPRLE 507
Score = 46.2 bits (108), Expect = 2e-04
Identities = 17/32 (53%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+++YI+H + T W DPR
Sbjct: 474 PLPPGWEERTHTDGRIFYINHNIKRTQWEDPR 505
Score = 43.9 bits (102), Expect = 9e-04
Identities = 16/31 (51%), Positives = 21/31 (67%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
PLP GWEE +D G+ YY++H +R T W P
Sbjct: 192 PLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
Score = 40.8 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 34/74 (45%)
Query: 52 SDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQK 111
S LP GWEE D + Y++DHN++TT P VQ E + ++ ++
Sbjct: 347 SSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTS 406
Query: 112 EIYQVKQQRLELAQ 125
+ Q Q E+ Q
Sbjct: 407 DSGQQVTQPSEIEQ 420
Score = 30.4 bits (67), Expect = 9.8
Identities = 13/33 (39%), Positives = 19/33 (57%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
LP GWEE D Y+++H ++ TQ + P Q
Sbjct: 193 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQ 225
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 68.9 bits (167), Expect = 2e-11
Identities = 41/106 (38%), Positives = 52/106 (49%), Gaps = 26/106 (24%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDR---YTKPLTFAD---------CISDE- 54
LP GWEE +D G+ YY+DH +RTT+W P + T LT + SD
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 55 -------------LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
LP GWE + P +FIDHNTKTT EDPR++
Sbjct: 757 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLK 802
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/85 (40%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR---DRYTKPLTFADCISD--ELPLGWEEA 62
LP+GWE +G+ ++IDH +TT+W DPR + + T D +D LP GWEE
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQ 87
++I+HN K TQ EDPR++
Sbjct: 830 THTDGRIFYINHNIKRTQWEDPRLE 854
Score = 46.2 bits (108), Expect = 2e-04
Identities = 17/32 (53%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+++YI+H + T W DPR
Sbjct: 821 PLPPGWEERTHTDGRIFYINHNIKRTQWEDPR 852
Score = 43.9 bits (102), Expect = 9e-04
Identities = 16/31 (51%), Positives = 21/31 (67%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
PLP GWEE +D G+ YY++H +R T W P
Sbjct: 539 PLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
Score = 40.8 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 34/74 (45%)
Query: 52 SDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQK 111
S LP GWEE D + Y++DHN++TT P VQ E + ++ ++
Sbjct: 694 SSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTS 753
Query: 112 EIYQVKQQRLELAQ 125
+ Q Q E+ Q
Sbjct: 754 DSGQQVTQPSEIEQ 767
Score = 30.4 bits (67), Expect = 9.8
Identities = 13/33 (39%), Positives = 19/33 (57%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQ 87
LP GWEE D Y+++H ++ TQ + P Q
Sbjct: 540 LPPGWEERQDILGRTYYVNHESRRTQWKRPTPQ 572
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKF 411
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 70 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 479 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 538
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 539 HLDGRTFYIDHNSKITQWEDPRLQ 562
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 529 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 560
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 427 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 486
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 487 IAPNGRPFFIDHNTKTTTWEDPRLKF 512
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 191 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQ 441
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKF 391
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 70 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQ 441
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKF 391
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 70 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 471 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 530
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 531 HLDGRTFYIDHNSKITQWEDPRLQ 554
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 521 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 552
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 419 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 478
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 479 IAPNGRPFFIDHNTKTTTWEDPRLKF 504
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 183 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 491 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 550
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 551 HLDGRTFYIDHNSKITQWEDPRLQ 574
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 541 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 572
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 438
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 439 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 498
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 499 IAPNGRPFFIDHNTKTTTWEDPRLKF 524
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 183 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 499 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 558
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 559 HLDGRTFYIDHNSKITQWEDPRLQ 582
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 549 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 580
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 446
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 447 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 506
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 507 IAPNGRPFFIDHNTKTTTWEDPRLKF 532
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 191 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKF 411
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 70 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 67.4 bits (163), Expect = 7e-11
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDE----LPLGWEEAY 63
LP GWE +G+ ++IDH +TT+W DPR ++ + ++ LP GWEE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 64 DPQVGDYFIDHNTKTTQIEDPRVQ 87
++IDHN+K TQ EDPR+Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 48.5 bits (114), Expect = 3e-05
Identities = 18/32 (56%), Positives = 22/32 (68%)
Query: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR 38
PLP GWEE DG+ +YIDH ++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/146 (26%), Positives = 52/146 (35%), Gaps = 65/146 (44%)
Query: 8 LPEGWEEARDFDGKVYYIDH-----------------------TNRTTSWIDPRDRYTKP 44
LP GWEE +D G+ YY++H TN I+P+ R +
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 325
Query: 45 LT---------------------FADCISDE---------------------LPLGWEEA 62
L+ D +S+ LP GWE
Sbjct: 326 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 385
Query: 63 YDPQVGDYFIDHNTKTTQIEDPRVQW 88
P +FIDHNTKTT EDPR+++
Sbjct: 386 IAPNGRPFFIDHNTKTTTWEDPRLKF 411
Score = 47.0 bits (110), Expect = 1e-04
Identities = 19/34 (55%), Positives = 22/34 (64%)
Query: 4 PELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
P PLP GWEE D G+ YY++H NRTT W P
Sbjct: 70 PPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 33.9 bits (76), Expect = 0.89
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 55 LPLGWEEAYDPQVGDYFIDHNTKTTQIEDP 84
LP GWEE D Y+++HN +TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|239047795 pleckstrin homology domain containing, family A
member 7 [Homo sapiens]
Length = 1121
Score = 63.9 bits (154), Expect = 8e-10
Identities = 30/77 (38%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
LPE W DG+V++I+ R T+W+ PR +P+ I +LP GWEE + +
Sbjct: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTG--EPVNSGHMIRSDLPRGWEEGFTEEG 68
Query: 68 GDYFIDHNTKTTQIEDP 84
YFIDHN +TT P
Sbjct: 69 ASYFIDHNQQTTAFRHP 85
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 62.4 bits (150), Expect = 2e-09
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
LP GWEE DG VYY +HT T W P+ K ++ +LP GWE+ D
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
Query: 68 GDYFIDHNTKTTQIEDPRV 86
+F+DH K T DPR+
Sbjct: 72 QVFFVDHINKRTTYLDPRL 90
Score = 47.0 bits (110), Expect = 1e-04
Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 6/45 (13%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR------DRYTKPLT 46
LP GWE+ D +G+V+++DH N+ T+++DPR D TKP T
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
Score = 32.3 bits (72), Expect = 2.6
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRR 90
DELP GWEE Y+ +H + TQ E P+ R+
Sbjct: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRK 53
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 62.4 bits (150), Expect = 2e-09
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
LP GWEE DG VYY +HT T W P+ K ++ +LP GWE+ D
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
Query: 68 GDYFIDHNTKTTQIEDPRV 86
+F+DH K T DPR+
Sbjct: 72 QVFFVDHINKRTTYLDPRL 90
Score = 47.0 bits (110), Expect = 1e-04
Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 6/45 (13%)
Query: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR------DRYTKPLT 46
LP GWE+ D +G+V+++DH N+ T+++DPR D TKP T
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
Score = 32.3 bits (72), Expect = 2.6
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRR 90
DELP GWEE Y+ +H + TQ E P+ R+
Sbjct: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRK 53
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 61.6 bits (148), Expect = 4e-09
Identities = 29/80 (36%), Positives = 36/80 (45%), Gaps = 12/80 (15%)
Query: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
+LPLP GW G+ YYIDH TT W P +R + LP GWE
Sbjct: 198 DLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWERVES 245
Query: 65 PQVGDYFIDHNTKTTQIEDP 84
+ G Y++DH K Q P
Sbjct: 246 SEFGTYYVDHTNKKAQYRHP 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,372,460
Number of Sequences: 37866
Number of extensions: 2020475
Number of successful extensions: 21299
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 667
Number of HSP's that attempted gapping in prelim test: 13493
Number of HSP's gapped (non-prelim): 5391
length of query: 1118
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1005
effective length of database: 13,968,660
effective search space: 14038503300
effective search space used: 14038503300
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.