Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 239787829
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239787829 glioma tumor suppressor candidate region gene 2
[Homo sapiens]
(478 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239787829 glioma tumor suppressor candidate region gene 2 [Ho... 936 0.0
gi|148746195 trichohyalin [Homo sapiens] 51 2e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 48 2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 48 2e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 43 6e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 43 6e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 43 6e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 43 6e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 43 6e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 43 6e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 43 6e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 43 6e-04
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 41 0.003
gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo s... 40 0.004
gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo sa... 40 0.004
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 40 0.004
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 40 0.005
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 40 0.005
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 40 0.005
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 40 0.005
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 40 0.006
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 40 0.006
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 40 0.006
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 40 0.006
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 40 0.006
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 39 0.010
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 39 0.014
gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1 [... 38 0.018
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 38 0.023
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 38 0.023
>gi|239787829 glioma tumor suppressor candidate region gene 2 [Homo
sapiens]
Length = 478
Score = 936 bits (2418), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 1 MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEV 60
MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEV
Sbjct: 1 MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAQEPLGLEV 60
Query: 61 DQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDL 120
DQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDL
Sbjct: 61 DQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDL 120
Query: 121 ILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRA 180
ILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRA
Sbjct: 121 ILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRA 180
Query: 181 KPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEV 240
KPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEV
Sbjct: 181 KPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEV 240
Query: 241 APAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEG 300
APAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEG
Sbjct: 241 APAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEG 300
Query: 301 LLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRA 360
LLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRA
Sbjct: 301 LLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRA 360
Query: 361 ARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQL 420
ARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQL
Sbjct: 361 ARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQL 420
Query: 421 SSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL 478
SSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL
Sbjct: 421 SSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL 478
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 51.2 bits (121), Expect = 2e-06
Identities = 77/345 (22%), Positives = 136/345 (39%), Gaps = 33/345 (9%)
Query: 146 RRKEQLWEKLAKQGELPREVRRAQARLLNPSA---TRAKPGPQDTVERPFYDLWAS--DN 200
RR E+LW + + E RE RRA+ L T P + R +L +
Sbjct: 168 RRDEELWRQRQEWQE--REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 201 PLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSA 260
+ QD F E+ +K+ KR L + + E ++ + L
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE-----PQRQRELQEEEEQLRK 280
Query: 261 AHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAG 320
EL+R+++ E+ ++Q + QE +E E E+ + + + +
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 321 DAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVAL 380
+ E++ EQQ RRE+ R Q + R Q+L R + ++ + L
Sbjct: 341 REQ-----------EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 381 RLAELARRQ----RRRQARREAEADKPRRLGR---LKYQAPDIDVQLSSELTDSLRTLKP 433
R + RR+ R +Q RRE + + ++L R L+ + + + E + LK
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Query: 434 EGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQL 478
E RD K R E E+ + K++ K E+R R ++L
Sbjct: 450 EQEERRDWLK---REEETERHEQERRKQQLKRDQEEERRERWLKL 491
Score = 43.1 bits (100), Expect = 6e-04
Identities = 48/213 (22%), Positives = 93/213 (43%), Gaps = 11/213 (5%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E +L+R++E E+ E++ EQ +E + EE++ + + + +
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRL 382
E E++ EQQ RRE+ + R + ++ R R +E + R ++++ LR
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR-LRSEQQLRR 540
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
+ RR++ + E ++ RR RLK + + QL LK E + R
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL----------LKREEERRQQRL 590
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
K Q + + +R + +R + + E+R RE
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Score = 32.7 bits (73), Expect = 0.74
Identities = 57/283 (20%), Positives = 106/283 (37%), Gaps = 20/283 (7%)
Query: 146 RRKEQL-----------WEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYD 194
RRK+QL W KL ++ ++ RR Q R + + E
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 195 LWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDH 254
S+ L R + E L++ ++K +++ R + + E
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERR----EQRLKREQEERRDQLLKREEERR 586
Query: 255 QTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQG 314
Q L E L+++ + E++ER EQ +E +E + LL+ + E Q
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 315 ---EGPEAGDAEVC--PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF 369
E E + + RL K+ ++ RRE+ + +QA R + +
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 370 RLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQ 412
+L ++ R+Q ++ R+E E + RR L++Q
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Score = 32.7 bits (73), Expect = 0.74
Identities = 101/497 (20%), Positives = 178/497 (35%), Gaps = 92/497 (18%)
Query: 36 RRRRGPRNKKRGWRRLAQEPLGLEVDQFLEDVRLQE--RTSGGLLSEAPNEKLFFVDTGS 93
RRR + + + WR +E LQE R LL E E
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL-------- 913
Query: 94 KEKGLTKKRTKVQKKSLLLKKPLRVD---LILENTSKVPAPKDVLAHQVPNAKKLRRKEQ 150
+ + K+R + Q++ ++ L+ + L+ E K + Q KKL++KE+
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK--RRRQERERQYRKDKKLQQKEE 971
Query: 151 --LWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVG 208
L E+ K+ RE + + L + ++ R ++ D
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE--RQYRKKDELQQE 1029
Query: 209 QDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR 268
+++ E+ +K+ ++ R + + + E G E+ +T E + ++
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLG-------EERETRRRQELERQYRK 1082
Query: 269 QKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTP 328
++E ++ E QL E+ QE Q C EE + + E Q E
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQ--CR---EEEELQQEEEQLLREE---------- 1127
Query: 329 ARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFR-------LRGIKAQVALR 381
R ++ E+Q R E+ V + Q + R QEL R L+ + Q+
Sbjct: 1128 -REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 382 LAELARRQRRRQARREAEADKPRRLGRLKY--QAPDIDVQLSSELTDSLRTLKP------ 433
E R++R RQ R E E + +R R + Q D+ Q E +++R K
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 434 -------EGNILRDRF----------------------------KSFQRRNMIEPRERAK 458
E + LRDR + F +E E+ +
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 459 FKRKYKVKLVEKRAFRE 475
KR+ + EK+ RE
Sbjct: 1307 AKRRDRKSQEEKQLLRE 1323
Score = 32.3 bits (72), Expect = 0.97
Identities = 44/182 (24%), Positives = 64/182 (35%), Gaps = 15/182 (8%)
Query: 312 GQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRL 371
GQ G + C L ++ E QRR E +L + R + + QE
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 372 RGIKAQVALRLAELARRQRR-------------RQARREAEADKPRRLGRLKYQAPDIDV 418
G + E RQRR R+ RR E G + PD +
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 419 QLSSELTDSLRTLKPEGNILR--DRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREI 476
EL + R + E R + + FQ E R+R RK + KL E+ R+
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 477 QL 478
+L
Sbjct: 270 EL 271
Score = 30.8 bits (68), Expect = 2.8
Identities = 57/246 (23%), Positives = 103/246 (41%), Gaps = 45/246 (18%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E L+RQ+E E+L+++L +EQ +E +E E LL+ + E Q +
Sbjct: 516 EQRLKRQEEEERLQQRLR---SEQQLRREQ--EERREQLLKREE-EKRLEQERREQRLKR 569
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---------- 372
E +L E++ QQR + + RL RL+ +E+ RL
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLE--------QRLKREEVERLEQEERREQRLK 621
Query: 373 ----GIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSL 428
+ + L +E +R++Q RRE + + +RL R + + ++ +L E +
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-EEEEERLEQRLKREHEEER 680
Query: 429 R---TLKPEGNILRDRFKS-------------FQRRNMIEPRERAKFKRKYKVKLVEKRA 472
R + E R+R KS R++ + R R + ++ + + EKR
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 473 FREIQL 478
RE +L
Sbjct: 741 RRESEL 746
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/235 (25%), Positives = 102/235 (43%), Gaps = 16/235 (6%)
Query: 252 EDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEP 311
E+ + L E + +R+ E KL+R+ L QA + +E + +E+ + +
Sbjct: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
Query: 312 GQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-- 369
+ E AE A ++ E +R++E+ RLR Q RHQEL
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ--EEEERRHQELLQK 666
Query: 370 -------RLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSS 422
RLR KA A RLAE ++RR Q RRE E R R + + + + QL+
Sbjct: 667 KKEEEQERLR--KAAEAKRLAEQREQERREQERREQER---REQERREQERREQERQLAE 721
Query: 423 ELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
+ + L++R K+ + + RE + K+K + + + +R +E Q
Sbjct: 722 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/235 (25%), Positives = 102/235 (43%), Gaps = 16/235 (6%)
Query: 252 EDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEP 311
E+ + L E + +R+ E KL+R+ L QA + +E + +E+ + +
Sbjct: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 604
Query: 312 GQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-- 369
+ E AE A ++ E +R++E+ RLR Q RHQEL
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQ--EEEERRHQELLQK 662
Query: 370 -------RLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSS 422
RLR KA A RLAE ++RR Q RRE E R R + + + + QL+
Sbjct: 663 KKEEEQERLR--KAAEAKRLAEQREQERREQERREQER---REQERREQERREQERQLAE 717
Query: 423 ELTDSLRTLKPEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
+ + L++R K+ + + RE + K+K + + + +R +E Q
Sbjct: 718 QERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1494
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1612
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1613 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1727
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1728 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1843 -----GEATRLKTEAEIALKEKEAENE 1864
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2328 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2387 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2441
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2502 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2534
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1803 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1856
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2094 EEARVQAEREAAQSRRQ 2110
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2098
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2099 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2208
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1729
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1782
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1885
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1886 QHKADI--EERLAQLRKASDSELERQKG 1911
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1385
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1386 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1440 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASR 1520
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1498
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1616
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1617 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1731
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1732 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1846
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1847 -----GEATRLKTEAEIALKEKEAENE 1868
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2332 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2391 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2445
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2506 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2538
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1807 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1860
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1918
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1919 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2098 EEARVQAEREAAQSRRQ 2114
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2102
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2103 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2212
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1733
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1786
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1889
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1890 QHKADI--EERLAQLRKASDSELERQKG 1915
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1389
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1390 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1443
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1444 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1496
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASR 1524
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1494
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1612
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1613 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1727
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1728 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1843 -----GEATRLKTEAEIALKEKEAENE 1864
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2328 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2387 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2441
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2502 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2534
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1803 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1856
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1914
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1915 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2094 EEARVQAEREAAQSRRQ 2110
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2098
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2099 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2208
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1729
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1782
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1885
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1886 QHKADI--EERLAQLRKASDSELERQKG 1911
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1385
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1386 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1440 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASR 1520
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1462
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1580
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1581 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1695
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1696 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1810
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1811 -----GEATRLKTEAEIALKEKEAENE 1832
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2296 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2355 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2409
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2470 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2502
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1771 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1824
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1882
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1883 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2062 EEARVQAEREAAQSRRQ 2078
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2066
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2067 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2120
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2176
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1697
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1750
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1853
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1854 QHKADI--EERLAQLRKASDSELERQKG 1879
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1353
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1354 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1407
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1408 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1460
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASR 1488
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1631
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1749
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1750 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1864
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1865 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1979
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1980 -----GEATRLKTEAEIALKEKEAENE 2001
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2465 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2524 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2578
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2639 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2671
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1940 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1993
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 2051
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 2052 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2231 EEARVQAEREAAQSRRQ 2247
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2235
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2236 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2345
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQME 2375
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1866
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1919
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 2022
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 2023 QHKADI--EERLAQLRKASDSELERQKG 2048
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1522
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1523 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1576
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1577 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1629
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASR 1657
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1472
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1590
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1591 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1705
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1706 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1820
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1821 -----GEATRLKTEAEIALKEKEAENE 1842
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2306 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2365 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2419
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2480 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2512
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1781 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1834
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1892
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1893 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2072 EEARVQAEREAAQSRRQ 2088
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2076
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2077 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2186
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2187 LQRLKAEATEAARQRSQVEEELFSVRVQME 2216
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1707
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1760
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1863
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1864 QHKADI--EERLAQLRKASDSELERQKG 1889
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1363
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1364 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1417
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1418 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1470
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASR 1498
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1480
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1598
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1599 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1713
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1714 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1828
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1829 -----GEATRLKTEAEIALKEKEAENE 1850
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2314 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2373 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2427
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2488 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2520
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1789 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1842
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1900
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1901 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1960
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2080 EEARVQAEREAAQSRRQ 2096
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2084
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2085 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2138
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2194
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2195 LQRLKAEATEAARQRSQVEEELFSVRVQME 2224
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1715
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1768
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1871
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1872 QHKADI--EERLAQLRKASDSELERQKG 1897
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1371
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1372 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1425
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1426 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1478
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASR 1506
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 43.1 bits (100), Expect = 6e-04
Identities = 99/447 (22%), Positives = 179/447 (40%), Gaps = 47/447 (10%)
Query: 52 AQEPLGLEVDQFLEDVRLQ----ERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQK 107
A E L +++ + VRLQ ER GG E + E+ +KR + Q+
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR------ARAEEAEAQKR-QAQE 1521
Query: 108 KSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRR 167
++ L++ ++ + + ++V V A +K R + L E + E R +R+
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581
Query: 168 AQ---ARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKR 224
A+ AR + + A+ + ++ L+R L Q+E ++ +R
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL--QEEHVAVAQLREEAER 1639
Query: 225 PARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQR---QKEAEKLERQLAL 281
A+ + +A E + + L A EV Q+ Q EAEK + +
Sbjct: 1640 RAQQQAEAERARE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 282 PATEQAATQESTFQ--ELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTE 339
A + +E + EL E LE+ E G + A + E+ A TE+ +
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAE-GTAQQRLAAEQELIRLRAE---TEQGEQ 1754
Query: 340 QQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQ-------RRR 392
Q++ E+ + RL Q+ A A + R + L ++A++ + LA AR + +
Sbjct: 1755 QRQLLEEELARL--QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 393 QARREAEADKPRRL----GRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRR 448
+ R EAEA + R L RL+ A + Q D+ R +L ++ +
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1869
Query: 449 NMIEPRERAKFKRKYKVKLVEKRAFRE 475
E + K + ++ L EK A E
Sbjct: 1870 -----GEATRLKTEAEIALKEKEAENE 1891
Score = 42.7 bits (99), Expect = 7e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 271 EAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPAR 330
EAE L++Q L A EQA + +++ + L EE+ G + E + +
Sbjct: 2355 EAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
Query: 331 LATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
L E Q R E A R R +QA +L EL + ++ E+ R+Q
Sbjct: 2414 LRVAEMSRAQARAEEDA-QRFR-KQAEEIGEKLHRTELATQEKV---TLVQTLEIQRQQS 2468
Query: 391 RRQAR--REAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKS---- 444
A REA A+ R +L+ +A + ++ T L E L+ F S
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 445 -FQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
QR IE +E+AK ++ ++ ++ + + RE Q
Sbjct: 2529 LLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQ 2561
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/377 (21%), Positives = 144/377 (38%), Gaps = 26/377 (6%)
Query: 99 TKKRTKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLR----RKEQLWEK 154
T+KR +++ + ++ + V L SK A ++ + + ++L R +L E+
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 155 LAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFL 214
A+ L E +R Q +L A R + ER + A+ R L + E L
Sbjct: 1830 AARLRALAEEAKR-QRQLAEEDAARQRA----EAERVLAEKLAAIGEATR-LKTEAEIAL 1883
Query: 215 EQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEK 274
++ + + + + Q +E A + E+ L A + EL+RQK +
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSELERQKGLVE 1941
Query: 275 LERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT 334
+ E+ +++F++ G E G E A
Sbjct: 1942 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQV--ALRLAELARRQRRR 392
E++RRRE + A AAR R L + +KA+V A RL E A ++ R
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061
Query: 393 QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLR-------TLKPEGNILRDRFKSF 445
Q + EA + R K A + Q EL +L+ L+ E R +
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120
Query: 446 QRRNMIEPRERAKFKRK 462
+ + RE A+ +R+
Sbjct: 2121 EEARVQAEREAAQSRRQ 2137
Score = 40.0 bits (92), Expect = 0.005
Identities = 51/210 (24%), Positives = 90/210 (42%), Gaps = 16/210 (7%)
Query: 267 QRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCP 326
Q++ +AE+ A+ EQ Q++ QE + +L++ GE E + EA +A V
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQEL-QQTLQQE--QSVLDQLRGEAEAARRAAEEAEEARV-- 2125
Query: 327 TPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELF-RLRGIKAQVALRLAEL 385
E++ Q RR+ + RL+ AR + Q +LR Q A R A+
Sbjct: 2126 ------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179
Query: 386 ARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSF 445
+ R++ +AE +K ++ Q Q+ ELT +LR E + ++
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELT-TLRLQLEETDHQKNLLDEE 2235
Query: 446 QRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+R E E A+ + + + +L R E
Sbjct: 2236 LQRLKAEATEAARQRSQVEEELFSVRVQME 2265
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 52/328 (15%)
Query: 95 EKGLTKKRTKVQKKSLLLKKPLRVDLILENTS--KVPAPKDVLAHQVPNAKKLRRKEQLW 152
E+ + ++++ L + LR+ L E + K A + + ++ RR+ +
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 153 EKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEF 212
E+ +Q EL + Q +L +A + Q+ + L A G+ +
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR-----LRAETEQ------GEQQR 1756
Query: 213 FLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEA 272
L + + ++R A T+ Q E+A A + + LL++ E + + +
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTS 1809
Query: 273 EKLERQLALPA------TEQAATQESTFQELC-EGLLEESDGEGEPGQGEGPEA------ 319
EK +++L A E+AA + +E + L E D + + E A
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 320 GDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVA 379
G+A T A +A EK+ E +R R RL E F+ R ++ Q A
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLR-----------------RLAEDEAFQRRRLEEQAA 1912
Query: 380 LRLAELARRQRRRQARREAEADKPRRLG 407
A++ +R Q R+ ++++ R+ G
Sbjct: 1913 QHKADI--EERLAQLRKASDSELERQKG 1938
Score = 31.6 bits (70), Expect = 1.7
Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 31/208 (14%)
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+R +E E+L Q E+ A E+ ++ + L E+ + +
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQAKAQ------------- 1412
Query: 326 PTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLR---GIKAQVALRL 382
A E K QQR +E+ V R A + R +EL +LR + Q R
Sbjct: 1413 ------AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1466
Query: 383 AELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRF 442
AE A R R R ++ R+ RL+ +A + + +LR E + +
Sbjct: 1467 AEAAERSRLR-------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1519
Query: 443 KSFQRRNMIEPRERAKFKRKYKVKLVEK 470
+ R + ++ ++ KR+ +V+L +
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASR 1547
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 40.8 bits (94), Expect = 0.003
Identities = 48/214 (22%), Positives = 86/214 (40%), Gaps = 34/214 (15%)
Query: 263 EVELQRQKEAE-----KLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGP 317
E E +RQ + E K ER+ A + A++ T ++ + D + + Q E
Sbjct: 221 ETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERE 280
Query: 318 EAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQ 377
D + R TE+K E+QR RE+ R R R R +E
Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERERERERNR--------KRERERE---------- 322
Query: 378 VALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSEL-TDSLRTLKPEGN 436
R+R R+ +RE E D+ + R + + ++D + + + + R + E
Sbjct: 323 ----------RERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Query: 437 ILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEK 470
R+R + R R+R + ++K + + EK
Sbjct: 373 RERERDRQSAREREERERDRDRDRQKERERQTEK 406
Score = 34.3 bits (77), Expect = 0.26
Identities = 38/133 (28%), Positives = 62/133 (46%), Gaps = 10/133 (7%)
Query: 334 TEKKTEQ--QRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELAR-RQR 390
TE++T++ +RRREK HR R + + R + +E R Q R E R ++R
Sbjct: 71 TERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQ---REKERNRQKER 127
Query: 391 RRQARREAEADKPRRLGRLKYQAPDIDVQLSSE-LTDSLRTLKPEGNILRDRFKSFQRRN 449
R+ RE E + R+ + + D + E TD R + E N ++R + +N
Sbjct: 128 ERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER---EKN 184
Query: 450 MIEPRERAKFKRK 462
E RER + + K
Sbjct: 185 RQERRERERQREK 197
>gi|187829452 autism susceptibility candidate 2 isoform 2 [Homo
sapiens]
Length = 1235
Score = 40.4 bits (93), Expect = 0.004
Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 18/130 (13%)
Query: 227 RLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQ 286
R + PS AP + V G + + + + L + A E + +++E + E + L A E
Sbjct: 826 RHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEH 885
Query: 287 AATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTP---------ARLATTEKK 337
A EG L E DG G G+ G EA P+P AR +T +
Sbjct: 886 KAK---------EGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSR 936
Query: 338 TEQQRRREKA 347
+ R+ E A
Sbjct: 937 EAEPRKGEPA 946
>gi|17864090 autism susceptibility candidate 2 isoform 1 [Homo
sapiens]
Length = 1259
Score = 40.4 bits (93), Expect = 0.004
Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 18/130 (13%)
Query: 227 RLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQ 286
R + PS AP + V G + + + + L + A E + +++E + E + L A E
Sbjct: 850 RHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEH 909
Query: 287 AATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTP---------ARLATTEKK 337
A EG L E DG G G+ G EA P+P AR +T +
Sbjct: 910 KAK---------EGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSR 960
Query: 338 TEQQRRREKA 347
+ R+ E A
Sbjct: 961 EAEPRKGEPA 970
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/283 (22%), Positives = 102/283 (36%), Gaps = 36/283 (12%)
Query: 127 KVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQD 186
K P+P+ A ++RRKE+ E + G + + +A SA A P P
Sbjct: 493 KPPSPRGTTASP---KGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAP-- 547
Query: 187 TVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGAS 246
S P P Q E +T A + T P APA V P+
Sbjct: 548 -----------SPAPSPTPAPPQKEQPPAETPTD-----AAVLTSPP-APAPPVTPSKPM 590
Query: 247 YNPSFEDHQTLLSAAHEVELQRQKEAEKLERQL------ALPATEQAATQESTFQELCEG 300
+ + T L A + + Q+E E+ ER+L + + A E+ + E
Sbjct: 591 AGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
Query: 301 LLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRA 360
E E Q E E + A + E+ Q+ REK QQ R
Sbjct: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQ----QQEQERQ 706
Query: 361 ARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKP 403
R + E R K++V +E ++Q ++A + +P
Sbjct: 707 ERRKRLEEIMKRTRKSEV----SETKQKQDSKEANANGSSPEP 745
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 40.0 bits (92), Expect = 0.005
Identities = 40/150 (26%), Positives = 72/150 (48%), Gaps = 13/150 (8%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E+ ++Q+EA + +R+ + Q +E QE LEE E E + +
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ------E 831
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRL 382
E+ A + E++ +R +RLR+++ AARLRH+E R R K R
Sbjct: 832 ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE---EAARLRHEEEERKR--KELEVQRQ 886
Query: 383 AELARRQRRRQ--ARREAEADKPRRLGRLK 410
EL R+++++Q RR + + ++L ++K
Sbjct: 887 KELMRQRQQQQEALRRLQQQQQQQQLAQMK 916
Score = 33.1 bits (74), Expect = 0.57
Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 336 KKTEQQRRREKAVHR-----LRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
K+ E++R+R++ + R LR QQ R R +EL R + +A R E+A R++
Sbjct: 743 KREEEERKRQEELRRQQEEILRRQQEEERKRR-EEEELARRKQEEALRRQREQEIALRRQ 801
Query: 391 RRQARREAEADKPRRL 406
R + R+ + + RRL
Sbjct: 802 REEEERQQQEEALRRL 817
Score = 30.8 bits (68), Expect = 2.8
Identities = 30/143 (20%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQA 394
E++ +R++E+A+ R R Q+ ALR R + + + ALR E RR+ +
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRRQREEEERQ------QQEEALRRLE-ERRREEEER 827
Query: 395 RREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPR 454
R++ E + + K+ + + Q L ++ ++ E LR + +R+ + R
Sbjct: 828 RKQEELLRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQR 885
Query: 455 ERAKFKRKYKVKLVEKRAFREIQ 477
++ +++ + ++ A R +Q
Sbjct: 886 QKELMRQRQQ----QQEALRRLQ 904
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 40.0 bits (92), Expect = 0.005
Identities = 40/150 (26%), Positives = 72/150 (48%), Gaps = 13/150 (8%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E+ ++Q+EA + +R+ + Q +E QE LEE E E + +
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ------E 858
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRL 382
E+ A + E++ +R +RLR+++ AARLRH+E R R K R
Sbjct: 859 ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE---EAARLRHEEEERKR--KELEVQRQ 913
Query: 383 AELARRQRRRQ--ARREAEADKPRRLGRLK 410
EL R+++++Q RR + + ++L ++K
Sbjct: 914 KELMRQRQQQQEALRRLQQQQQQQQLAQMK 943
Score = 33.1 bits (74), Expect = 0.57
Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 336 KKTEQQRRREKAVHR-----LRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
K+ E++R+R++ + R LR QQ R R +EL R + +A R E+A R++
Sbjct: 770 KREEEERKRQEELRRQQEEILRRQQEEERKRR-EEEELARRKQEEALRRQREQEIALRRQ 828
Query: 391 RRQARREAEADKPRRL 406
R + R+ + + RRL
Sbjct: 829 REEEERQQQEEALRRL 844
Score = 30.8 bits (68), Expect = 2.8
Identities = 30/143 (20%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQA 394
E++ +R++E+A+ R R Q+ ALR R + + + ALR E RR+ +
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRRQREEEERQ------QQEEALRRLE-ERRREEEER 854
Query: 395 RREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPR 454
R++ E + + K+ + + Q L ++ ++ E LR + +R+ + R
Sbjct: 855 RKQEELLRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQR 912
Query: 455 ERAKFKRKYKVKLVEKRAFREIQ 477
++ +++ + ++ A R +Q
Sbjct: 913 QKELMRQRQQ----QQEALRRLQ 931
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.0 bits (92), Expect = 0.005
Identities = 40/150 (26%), Positives = 72/150 (48%), Gaps = 13/150 (8%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E+ ++Q+EA + +R+ + Q +E QE LEE E E + +
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ------E 837
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRL 382
E+ A + E++ +R +RLR+++ AARLRH+E R R K R
Sbjct: 838 ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE---EAARLRHEEEERKR--KELEVQRQ 892
Query: 383 AELARRQRRRQ--ARREAEADKPRRLGRLK 410
EL R+++++Q RR + + ++L ++K
Sbjct: 893 KELMRQRQQQQEALRRLQQQQQQQQLAQMK 922
Score = 33.1 bits (74), Expect = 0.57
Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 336 KKTEQQRRREKAVHR-----LRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
K+ E++R+R++ + R LR QQ R R +EL R + +A R E+A R++
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRR-EEEELARRKQEEALRRQREQEIALRRQ 807
Query: 391 RRQARREAEADKPRRL 406
R + R+ + + RRL
Sbjct: 808 REEEERQQQEEALRRL 823
Score = 30.8 bits (68), Expect = 2.8
Identities = 30/143 (20%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQA 394
E++ +R++E+A+ R R Q+ ALR R + + + ALR E RR+ +
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ------QQEEALRRLE-ERRREEEER 833
Query: 395 RREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPR 454
R++ E + + K+ + + Q L ++ ++ E LR + +R+ + R
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQR 891
Query: 455 ERAKFKRKYKVKLVEKRAFREIQ 477
++ +++ + ++ A R +Q
Sbjct: 892 QKELMRQRQQ----QQEALRRLQ 910
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 40.0 bits (92), Expect = 0.005
Identities = 40/150 (26%), Positives = 72/150 (48%), Gaps = 13/150 (8%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E+ ++Q+EA + +R+ + Q +E QE LEE E E + +
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ------E 837
Query: 323 EVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRL 382
E+ A + E++ +R +RLR+++ AARLRH+E R R K R
Sbjct: 838 ELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE---EAARLRHEEEERKR--KELEVQRQ 892
Query: 383 AELARRQRRRQ--ARREAEADKPRRLGRLK 410
EL R+++++Q RR + + ++L ++K
Sbjct: 893 KELMRQRQQQQEALRRLQQQQQQQQLAQMK 922
Score = 33.1 bits (74), Expect = 0.57
Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 6/76 (7%)
Query: 336 KKTEQQRRREKAVHR-----LRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQR 390
K+ E++R+R++ + R LR QQ R R +EL R + +A R E+A R++
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRR-EEEELARRKQEEALRRQREQEIALRRQ 807
Query: 391 RRQARREAEADKPRRL 406
R + R+ + + RRL
Sbjct: 808 REEEERQQQEEALRRL 823
Score = 30.8 bits (68), Expect = 2.8
Identities = 30/143 (20%), Positives = 67/143 (46%), Gaps = 13/143 (9%)
Query: 335 EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQA 394
E++ +R++E+A+ R R Q+ ALR R + + + ALR E RR+ +
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ------QQEEALRRLE-ERRREEEER 833
Query: 395 RREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNMIEPR 454
R++ E + + K+ + + Q L ++ ++ E LR + +R+ + R
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQR 891
Query: 455 ERAKFKRKYKVKLVEKRAFREIQ 477
++ +++ + ++ A R +Q
Sbjct: 892 QKELMRQRQQ----QQEALRRLQ 910
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 39.7 bits (91), Expect = 0.006
Identities = 64/289 (22%), Positives = 117/289 (40%), Gaps = 44/289 (15%)
Query: 138 QVPNAKKLRRKE-QLW----------EKLAKQGELPREVRRAQARLLNPS------ATRA 180
QV A++ +R+E Q W E+ K+ E R++ + + + LNP+ A +
Sbjct: 1402 QVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQM 1461
Query: 181 KPGPQDTVERPFYDLWASDNPLDRP--LVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAV 238
KP T++RP + P +P + +D ++ +K++ S ++
Sbjct: 1462 KPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEE-----------LSSGDSL 1510
Query: 239 EVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELC 298
P E Q + H V++ KE ++L+ + A E ++ +
Sbjct: 1511 SPDPWKRDAKEKLEKQQQM----HIVDML-SKEIQELQSKPDRSAEESDRLRKLMLEWQF 1565
Query: 299 EGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAAL 358
+ L+ES + E + E E D + RL E +RR A+ + V
Sbjct: 1566 QKRLQESKQKDEDDEEE--EDDDVDTMLIMQRL-------EAERRARTAMPAISVLDLLQ 1616
Query: 359 RAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLG 407
R R Q+L +R +A+ R E RRQ + +R+AE + + G
Sbjct: 1617 DEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEG 1665
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 39.7 bits (91), Expect = 0.006
Identities = 110/467 (23%), Positives = 179/467 (38%), Gaps = 74/467 (15%)
Query: 10 GKRSSKSDADSGFLGLRPTSVDPALRRRRRG-----PRNKKRGWRRLAQEPLG-LEVDQF 63
G R +A++ GLR + A R R G + + WRR +E G LE
Sbjct: 1360 GSRVRAMEAEAA--GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-- 1415
Query: 64 LEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILE 123
E+ R + L++ EK VD E+G + + ++ ++ L++ ++ LE
Sbjct: 1416 -EEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVSTLE 1472
Query: 124 NTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPG 183
+ +LA + A LR E+ E+ +G R +AR L S TRA
Sbjct: 1473 KKQR--KFDQLLAEE--KAAVLRAVEER-ERAEAEG------REREARAL--SLTRALEE 1519
Query: 184 PQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAP- 242
Q+ E A L+ L +D+ + + R A +A E+
Sbjct: 1520 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1579
Query: 243 --AGASYNPSFEDHQTLLSAAHEVELQRQKEA-EKLERQLA--LPATEQAATQESTFQEL 297
A E L HE +LQ + EA E+ RQLA L E +E + L
Sbjct: 1580 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1639
Query: 298 CEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAA 357
++ +GE E + + AG +E+AV +LR QA
Sbjct: 1640 AVAARKKLEGELEELKAQMASAGQG---------------------KEEAVKQLRKMQAQ 1678
Query: 358 LRA-------ARLRHQELF--------RLRGIKAQVALRLAELA---RRQRRRQARREAE 399
++ R +E+F RL+G++A+V ELA R +R+ Q R+
Sbjct: 1679 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1738
Query: 400 ADKPRRLGRLKYQAPDIDVQLS---SELTDSLRTLKPEGNILRDRFK 443
AD+ K + QL +L + L + +L DR++
Sbjct: 1739 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYR 1785
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 39.7 bits (91), Expect = 0.006
Identities = 110/467 (23%), Positives = 179/467 (38%), Gaps = 74/467 (15%)
Query: 10 GKRSSKSDADSGFLGLRPTSVDPALRRRRRG-----PRNKKRGWRRLAQEPLG-LEVDQF 63
G R +A++ GLR + A R R G + + WRR +E G LE
Sbjct: 1352 GSRVRAMEAEAA--GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-- 1407
Query: 64 LEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILE 123
E+ R + L++ EK VD E+G + + ++ ++ L++ ++ LE
Sbjct: 1408 -EEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVSTLE 1464
Query: 124 NTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPG 183
+ +LA + A LR E+ E+ +G R +AR L S TRA
Sbjct: 1465 KKQR--KFDQLLAEE--KAAVLRAVEER-ERAEAEG------REREARAL--SLTRALEE 1511
Query: 184 PQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAP- 242
Q+ E A L+ L +D+ + + R A +A E+
Sbjct: 1512 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1571
Query: 243 --AGASYNPSFEDHQTLLSAAHEVELQRQKEA-EKLERQLA--LPATEQAATQESTFQEL 297
A E L HE +LQ + EA E+ RQLA L E +E + L
Sbjct: 1572 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1631
Query: 298 CEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAA 357
++ +GE E + + AG +E+AV +LR QA
Sbjct: 1632 AVAARKKLEGELEELKAQMASAGQG---------------------KEEAVKQLRKMQAQ 1670
Query: 358 LRA-------ARLRHQELF--------RLRGIKAQVALRLAELA---RRQRRRQARREAE 399
++ R +E+F RL+G++A+V ELA R +R+ Q R+
Sbjct: 1671 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1730
Query: 400 ADKPRRLGRLKYQAPDIDVQLS---SELTDSLRTLKPEGNILRDRFK 443
AD+ K + QL +L + L + +L DR++
Sbjct: 1731 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYR 1777
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 39.7 bits (91), Expect = 0.006
Identities = 110/467 (23%), Positives = 179/467 (38%), Gaps = 74/467 (15%)
Query: 10 GKRSSKSDADSGFLGLRPTSVDPALRRRRRG-----PRNKKRGWRRLAQEPLG-LEVDQF 63
G R +A++ GLR + A R R G + + WRR +E G LE
Sbjct: 1393 GSRVRAMEAEAA--GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-- 1448
Query: 64 LEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSLLLKKPLRVDLILE 123
E+ R + L++ EK VD E+G + + ++ ++ L++ ++ LE
Sbjct: 1449 -EEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVSTLE 1505
Query: 124 NTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPG 183
+ +LA + A LR E+ E+ +G R +AR L S TRA
Sbjct: 1506 KKQR--KFDQLLAEE--KAAVLRAVEER-ERAEAEG------REREARAL--SLTRALEE 1552
Query: 184 PQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAP- 242
Q+ E A L+ L +D+ + + R A +A E+
Sbjct: 1553 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1612
Query: 243 --AGASYNPSFEDHQTLLSAAHEVELQRQKEA-EKLERQLA--LPATEQAATQESTFQEL 297
A E L HE +LQ + EA E+ RQLA L E +E + L
Sbjct: 1613 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1672
Query: 298 CEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAA 357
++ +GE E + + AG +E+AV +LR QA
Sbjct: 1673 AVAARKKLEGELEELKAQMASAGQG---------------------KEEAVKQLRKMQAQ 1711
Query: 358 LRA-------ARLRHQELF--------RLRGIKAQVALRLAELA---RRQRRRQARREAE 399
++ R +E+F RL+G++A+V ELA R +R+ Q R+
Sbjct: 1712 MKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1771
Query: 400 ADKPRRLGRLKYQAPDIDVQLS---SELTDSLRTLKPEGNILRDRFK 443
AD+ K + QL +L + L + +L DR++
Sbjct: 1772 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYR 1818
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 39.7 bits (91), Expect = 0.006
Identities = 103/442 (23%), Positives = 168/442 (38%), Gaps = 58/442 (13%)
Query: 30 VDPALRRRRRGPRNKKRGWRRLAQEPLGLEVDQF---------LEDVRLQERTSGGLLSE 80
++ AL RRR +R +E GL + F LE + +R + L E
Sbjct: 1498 LERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEE 1557
Query: 81 APN--EKLFFVDTGSKEKGLTKKRTKVQKKSLLLK-KPLRVDLILENTSKVPAPKDVLAH 137
+ +++ +E TKK + +K + + L LE T + ++
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQV 1617
Query: 138 QVPNAKKLRRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWA 197
+ +KL K++ L + + R V QA L + TRA+ ++ DL
Sbjct: 1618 KAEVDRKLAEKDEECANLRRNHQ--RAVESLQASL--DAETRARNEALRLKKKMEGDL-- 1671
Query: 198 SDNPLDRPLVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNP---SFEDH 254
N L+ L + T+ + R + K QA E A + + E
Sbjct: 1672 --NDLELQLGHATR---QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERR 1726
Query: 255 QTLLSAAHE---VELQRQKEAEKLERQLALPATEQAATQESTFQELC------EGLLEES 305
+LL+A E L++ + + +L Q L ATE+ S L E L +
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQL 1786
Query: 306 DGEGEPGQGEGPEAGD-AEVCPTPARLATTE--------------KKTEQQRRREKAVHR 350
GE E E EA + A+ T A + E KKT +Q RE
Sbjct: 1787 SGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARL 1846
Query: 351 LRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLK 410
+QAALR + + Q+L +A+V AEL Q++ + RR+ L
Sbjct: 1847 EEAEQAALRGGKKQVQKL------EAKVRELEAELDAEQKKHAEALKGVRKHERRVKELA 1900
Query: 411 YQAPDIDVQLS--SELTDSLRT 430
YQA + L+ +L D L++
Sbjct: 1901 YQAEEDRKNLARMQDLVDKLQS 1922
Score = 32.3 bits (72), Expect = 0.97
Identities = 65/314 (20%), Positives = 113/314 (35%), Gaps = 39/314 (12%)
Query: 149 EQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQD---TVERPFYDLWASDNP---L 202
++L E+L + E+ ++ A+ R L T K D T+ + + A++N L
Sbjct: 969 KELSERLEDEEEVNADLA-ARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNL 1027
Query: 203 DRPLVGQDEFFLEQTKKKGVKRPARLHT----KPSQAPAVEVAPAGASYNPSFEDHQTLL 258
+ DE TK+K + A + + + A ED + L
Sbjct: 1028 TEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSL 1087
Query: 259 SAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEG--------- 309
++ + ++ KLE L L T+++ + ++ E L++ D E
Sbjct: 1088 EQEKKLRMDTERAKRKLEGDLKL--TQESVADAAQDKQQLEEKLKKKDSELSQLSLRVED 1145
Query: 310 ------------EPGQGEGPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAA 357
+ Q E + AR +++ E R E+ RL A
Sbjct: 1146 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGA 1205
Query: 358 L----RAARLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAE-ADKPRRLGRLKYQ 412
R R EL RLR + ALR RR+QA AE ++ L R++ +
Sbjct: 1206 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQK 1265
Query: 413 APDIDVQLSSELTD 426
+L E+ D
Sbjct: 1266 LEKEKSELRMEVDD 1279
Score = 30.0 bits (66), Expect = 4.8
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 11/133 (8%)
Query: 266 LQRQKEAEKLERQLALPATE-----QAATQESTFQELCEGLLEESDGEGEPGQGEGPEAG 320
+QR +E E+ +++LAL E +AA + + E + L +++ E + E +
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAK-LRLQTESEDVTLELERATSA 1487
Query: 321 DAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVAL 380
A + L E+ E++RR+E+ + R +AA R +R ELFRLR +
Sbjct: 1488 AAALDKKQRHL---ERALEERRRQEEEMQR--ELEAAQRESRGLGTELFRLRHGHEEALE 1542
Query: 381 RLAELARRQRRRQ 393
L L R + Q
Sbjct: 1543 ALETLKRENKNLQ 1555
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 38.9 bits (89), Expect = 0.010
Identities = 72/327 (22%), Positives = 130/327 (39%), Gaps = 35/327 (10%)
Query: 146 RRKEQLWEKLAKQGELPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRP 205
R +++ E+L + E+ R+ R+ A A T+ L L R
Sbjct: 784 REEQERLEELRLEQEVARQGLEGSLRVAE-QAQEALEQQLPTLRHERSQLQEQLAQLSRQ 842
Query: 206 LVGQDEFFLEQTKKKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVE 265
L G+++ LEQ +++ ++ L + A+ AG + + + +
Sbjct: 843 LSGREQE-LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 266 LQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVC 325
L+ +KEA LE L Q A E+ ++L E++G+ E E+
Sbjct: 902 LRLEKEA--LEGSL-FEVQRQLAQLEARREQL------EAEGQALL---LAKETLTGELA 949
Query: 326 PTPARLATTEKKT--EQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLA 383
++ T++K +++ +K V R QA+LR R H+E + + + A R
Sbjct: 950 GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 384 ELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFK 443
E R Q + Q +RE E L RL+ + ++ SE +L+ + EG +L +
Sbjct: 1010 EAERAQLQSQLQREQE----ELLARLEAEKEEL-----SEEIAALQQERDEGLLLAES-- 1058
Query: 444 SFQRRNMIEPRERAKFKRKYKVKLVEK 470
E ++ K K L EK
Sbjct: 1059 --------EKQQALSLKESEKTALSEK 1077
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 38.5 bits (88), Expect = 0.014
Identities = 39/171 (22%), Positives = 81/171 (47%), Gaps = 21/171 (12%)
Query: 327 TPARLATTEKKTEQQRRR-------EKAVHRLRVQQAALRAARLR-------HQELFRL- 371
+P +L T ++ E+QR+ E+A RL ++ A AR + +Q+ ++
Sbjct: 243 SPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIF 302
Query: 372 RGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLK--YQAPDIDVQLSSELTDSLR 429
+G + E RQRR +R+AE + RR+ K + ++ + + + +
Sbjct: 303 KGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYK 362
Query: 430 TLKPE---GNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFREIQ 477
T+ E L F+ ++ M E + R + +RK+K+++ EK+ F +++
Sbjct: 363 TISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEM-EKQEFEQLR 412
Score = 32.0 bits (71), Expect = 1.3
Identities = 53/240 (22%), Positives = 98/240 (40%), Gaps = 28/240 (11%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDA 322
E+E QRQ+E K + EQ ++ Q E+ + G E GD
Sbjct: 108 EMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDD 167
Query: 323 EVCPT--PARLATT-----------EKKTEQQRR---REKAVHRLRVQQAALRAAR---L 363
+ T P + T EK+ E++ R E R Q+ +L+ A+ L
Sbjct: 168 SLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSL 227
Query: 364 RHQELFRLRGIKAQVA---LRLA-ELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQ 419
+ K ++ L+L E RQR+ +++AE + +RL K + Q
Sbjct: 228 VMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQ 287
Query: 420 LSSELTDSLRTLK----PEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFRE 475
+ +E ++ T K L+ F+ +R+ + + +A+ + + +++ EK+AF E
Sbjct: 288 MVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIE-EEKKAFAE 346
>gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
[Homo sapiens]
Length = 871
Score = 38.1 bits (87), Expect = 0.018
Identities = 74/308 (24%), Positives = 119/308 (38%), Gaps = 34/308 (11%)
Query: 137 HQVPNAKKLRRKEQLWEKLAKQGELPREVRRAQ----ARLLNPSATRAKPGPQDTVERPF 192
H VP L R + L ++G + + + + PS + P RP
Sbjct: 51 HCVPPFSPLARSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPL 110
Query: 193 YDL------WASDNPLDRPLVGQDEFFLEQTKKKGVKRP-ARLHTKPSQAPAVEVAPAGA 245
L W SD PL +P QD ++ +RP + + + E G
Sbjct: 111 STLPRMAPTWLSDIPLVQPPGHQDV----SERRLDTQRPQVTMWERDVSSDRQEPGRRGR 166
Query: 246 SYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEES 305
S+ E Q L A EV +++ +E +LE ++ L +E++ Q+ LE
Sbjct: 167 SWG--LEGSQALSQQA-EVIVRQLQELRRLEEEVRL-------LRETSLQQKMR--LEAQ 214
Query: 306 DGEGEPGQGEGPEAGDAEVCPTPARLATTE---KKTEQQRRRE-KAVHRLRVQQAALRAA 361
E E +AG AE A LA E K E+ +RE + V RL +Q L +
Sbjct: 215 AMELE-ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQ--LSSL 271
Query: 362 RLRHQELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQLS 421
H+E KA+ + +R +A+ AEA + L R + D++
Sbjct: 272 TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ 331
Query: 422 SELTDSLR 429
L ++LR
Sbjct: 332 VTLVENLR 339
Score = 36.2 bits (82), Expect = 0.067
Identities = 47/164 (28%), Positives = 69/164 (42%), Gaps = 33/164 (20%)
Query: 252 EDHQTLLSAAHEVELQRQKEAEKLERQLALPATEQAATQESTFQELCEGLLEESDGEGEP 311
+ ++L S ++E+ RQ + E E +L Q TQ+ QEL L+E E E
Sbjct: 646 QTQESLASLGLQLEVARQGQQESTEEAASL---RQELTQQ---QELYGQALQEKVAEVET 699
Query: 312 GQGEGPEAGDAEVCPTPARLATTEKKTEQQRRRE-KAVHRLRVQQAALRAARLRHQELFR 370
E +L+ TE++ + RR KAV LR Q + R QEL R
Sbjct: 700 RLRE--------------QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRR 745
Query: 371 LRGIKAQVALRLAELARRQRRRQARR--EAEADKPRRLGRLKYQ 412
L+ E + + +R ARR E E DK L L+ +
Sbjct: 746 LQ----------EEARKEEGQRLARRLQELERDKNLMLATLQQE 779
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 37.7 bits (86), Expect = 0.023
Identities = 46/199 (23%), Positives = 78/199 (39%), Gaps = 22/199 (11%)
Query: 265 ELQRQKEAEKLERQLALPATEQAATQESTFQELCEGL---LEESDGEGEPGQGEGPEAGD 321
+LQRQ+E + Q L +Q + E CE + L++ D + +
Sbjct: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
Query: 322 AEVCPTPARLATTEKKTEQQ--------------RRREKAVHRL--RVQQAALRAARLRH 365
E+ ++ TEK ++ R E + +L R +Q R L
Sbjct: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
Query: 366 QELFRLRGIKAQVALRLAELARRQRRRQARREAEADKPRRLGRLKYQAPDIDVQL---SS 422
EL + +Q LR AE R Q R+ + ++ R R + + ++ QL SS
Sbjct: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
Query: 423 ELTDSLRTLKPEGNILRDR 441
LT +LR +G ++R
Sbjct: 792 ALTRALRAEFEKGREEQER 810
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 37.7 bits (86), Expect = 0.023
Identities = 40/147 (27%), Positives = 57/147 (38%), Gaps = 21/147 (14%)
Query: 263 EVELQRQKEAEKLERQLALPATEQAATQESTFQELCE-------GLLEESDGEGEPGQGE 315
E E ++ L +Q A P E+A + + E G E S G+P G
Sbjct: 335 EKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGT 394
Query: 316 GPEAGDAEVCPTPARLATTEKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIK 375
A++ R A +K+ E+Q R EK RL +EL R
Sbjct: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKE-----------EQDRLEREELKRKA--- 440
Query: 376 AQVALRLAELARRQRRRQARREAEADK 402
+ LRL E AR+Q + R+E E K
Sbjct: 441 EEERLRLEEEARKQEEERKRQEEEKKK 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,840,271
Number of Sequences: 37866
Number of extensions: 941485
Number of successful extensions: 4402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 3973
Number of HSP's gapped (non-prelim): 571
length of query: 478
length of database: 18,247,518
effective HSP length: 106
effective length of query: 372
effective length of database: 14,233,722
effective search space: 5294944584
effective search space used: 5294944584
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.