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Search of human proteins with 119964721
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119964721 fer (fps/fes related) tyrosine kinase [Homo
sapiens]
(822 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 1624 0.0
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 800 0.0
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 719 0.0
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 580 e-165
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 499 e-141
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 289 8e-78
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 289 8e-78
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 281 2e-75
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 281 2e-75
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 281 2e-75
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 281 2e-75
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 281 2e-75
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 264 3e-70
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 264 3e-70
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 264 3e-70
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 259 5e-69
gi|4503787 fyn-related kinase [Homo sapiens] 258 1e-68
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 253 4e-67
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 253 4e-67
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 253 4e-67
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 253 5e-67
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 251 2e-66
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 249 1e-65
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 249 1e-65
gi|187475373 c-src tyrosine kinase [Homo sapiens] 248 2e-65
gi|4758078 c-src tyrosine kinase [Homo sapiens] 248 2e-65
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 247 3e-65
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 246 6e-65
gi|148596974 TXK tyrosine kinase [Homo sapiens] 245 1e-64
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 245 1e-64
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 1624 bits (4205), Expect = 0.0
Identities = 822/822 (100%), Positives = 822/822 (100%)
Query: 1 MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ 60
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ
Sbjct: 1 MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ 60
Query: 61 MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ 120
MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ
Sbjct: 61 MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ 120
Query: 121 IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM 180
IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM
Sbjct: 121 IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM 180
Query: 181 LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI 240
LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI
Sbjct: 181 LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI 240
Query: 241 VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL 300
VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL
Sbjct: 241 VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL 300
Query: 301 TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL 360
TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL
Sbjct: 301 TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL 360
Query: 361 EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK 420
EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK
Sbjct: 361 EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK 420
Query: 421 FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF 480
FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF
Sbjct: 421 FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF 480
Query: 481 LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK 540
LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK
Sbjct: 481 LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK 540
Query: 541 KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE 600
KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE
Sbjct: 541 KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE 600
Query: 601 LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ 660
LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ
Sbjct: 601 LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ 660
Query: 661 LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK 720
LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK
Sbjct: 661 LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK 720
Query: 721 QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS 780
QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS
Sbjct: 721 QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS 780
Query: 781 APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT 822
APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Sbjct: 781 APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT 822
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 800 bits (2066), Expect = 0.0
Identities = 420/827 (50%), Positives = 574/827 (69%), Gaps = 14/827 (1%)
Query: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
++ S +S+SW + QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
QQ++ E+ K ++EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
Query: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM LK I EY +I+SLV +
Sbjct: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQD 239
Query: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWN 298
E+V +H+E+ + +I P EY F+ + + + FD SLLEE E L+ E+ N
Sbjct: 240 EVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLN 299
Query: 299 NLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQ 358
LT ES+Q L ++ +EL +M+ ++E V +L++ + E + + V LL ++Q
Sbjct: 300 ELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPR-ERVQLLGKRQ 358
Query: 359 ALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKE-- 416
L+E Q +Q C++AK AQ+ELL+ K++ EPPPV+ ++D S +S E++
Sbjct: 359 VLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREG 418
Query: 417 -RLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK 475
R E ++ I+GI R PK +L +I +KPL EQ WYHGAIPR E ELL
Sbjct: 419 GRTPTLEILKSHISGIFR-PKFSLPPPL--QLIPEVQKPLHEQLWYHGAIPRAEVAELLV 475
Query: 476 KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTK 535
GDFLVRES GK EYVLSV DG RHFIIQ +DN+YR EG GF +IP LIDH +T+
Sbjct: 476 HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQ 534
Query: 536 QVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKTCK 594
Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+C+
Sbjct: 535 QPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR 593
Query: 595 EDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD 654
E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 594 ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA 653
Query: 655 ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVY 714
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E GVY
Sbjct: 654 RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVY 713
Query: 715 SSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV 773
++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE V
Sbjct: 714 AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV 773
Query: 774 ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
E+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 774 EKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 820
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 719 bits (1856), Expect = 0.0
Identities = 398/827 (48%), Positives = 534/827 (64%), Gaps = 72/827 (8%)
Query: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +S
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQ---DSG 57
Query: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
Q +S S I +TH++D+
Sbjct: 58 GQSRAISPDSP--------------ISQTHSQDI-------------------------- 77
Query: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 78 ---------------EKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 121
Query: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM LK I EY +I+SLV +
Sbjct: 122 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQD 181
Query: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWN 298
E+V +H+E+ + +I P EY F+ + + + FD SLLEE E L+ E+ N
Sbjct: 182 EVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLN 241
Query: 299 NLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQ 358
LT ES+Q L ++ +EL +M+ ++E V +L++ + E + + V LL ++Q
Sbjct: 242 ELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPR-ERVQLLGKRQ 300
Query: 359 ALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKE-- 416
L+E Q +Q C++AK AQ+ELL+ K++ EPPPV+ ++D S +S E++
Sbjct: 301 VLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREG 360
Query: 417 -RLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK 475
R E ++ I+GI R PK +L +I +KPL EQ WYHGAIPR E ELL
Sbjct: 361 GRTPTLEILKSHISGIFR-PKFSLPPPL--QLIPEVQKPLHEQLWYHGAIPRAEVAELLV 417
Query: 476 KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTK 535
GDFLVRES GK EYVLSV DG RHFIIQ +DN+YR EG GF +IP LIDH +T+
Sbjct: 418 HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQ 476
Query: 536 QVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKTCK 594
Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+C+
Sbjct: 477 QPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR 535
Query: 595 EDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD 654
E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 536 ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA 595
Query: 655 ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVY 714
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E GVY
Sbjct: 596 RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVY 655
Query: 715 SSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV 773
++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE V
Sbjct: 656 AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV 715
Query: 774 ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
E+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 716 EKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 762
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 580 bits (1494), Expect = e-165
Identities = 348/829 (41%), Positives = 495/829 (59%), Gaps = 88/829 (10%)
Query: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
++ S +S+SW + QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
QQ++ E+ K ++EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
Query: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM + + +
Sbjct: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEM---------------ACILK 224
Query: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAK----EQEIEFDTSLLEENENLQANE 294
EI+ + EI V+ + + +HR AA + E E+ L +
Sbjct: 225 EILQEYLEISSLVQ--------DEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPP 276
Query: 295 IMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLEL-EKRIEESSETCEKKSDIVLL 353
+ T E L++ + L E L+L E +E T +D + +
Sbjct: 277 CV--------------TFDESLLEEGEPL---EPGELQLNELTVESVQHTLTSVTDELAV 319
Query: 354 LSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSME 413
TE F Q E++ Q QE + N EE+ E
Sbjct: 320 ------------------ATEMVFRRQ-EMVTQLQQE--------LRNEEENTHP---RE 349
Query: 414 RKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQEL 473
R + L K + ++ ++ G+ + S A +++ + L + + + +
Sbjct: 350 RVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHST 409
Query: 474 LKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYT 533
+ + RE P +L + G R N+YR EG GF +IP LIDH +
Sbjct: 410 SSSEQE---REGGRTPTLEILKSHISGIFR----PKFSNLYRLEGEGFPSIPLLIDHLLS 462
Query: 534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKT 592
T+Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+
Sbjct: 463 TQQPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS 521
Query: 593 CKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRK 652
C+E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 522 CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE 581
Query: 653 KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG 712
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E G
Sbjct: 582 GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 641
Query: 713 VYSSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE 771
VY++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE
Sbjct: 642 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 701
Query: 772 QVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
VE+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 702 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 750
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 499 bits (1284), Expect = e-141
Identities = 326/829 (39%), Positives = 455/829 (54%), Gaps = 146/829 (17%)
Query: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +S
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQ---DSG 57
Query: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
Q +S S I +TH++D+
Sbjct: 58 GQSRAISPDSP--------------ISQTHSQDI-------------------------- 77
Query: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 78 ---------------EKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 121
Query: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM + + +
Sbjct: 122 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEM---------------ACILK 166
Query: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAK----EQEIEFDTSLLEENENLQANE 294
EI+ + EI V+ + + +HR AA + E E+ L +
Sbjct: 167 EILQEYLEISSLVQ--------DEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPP 218
Query: 295 IMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLEL-EKRIEESSETCEKKSDIVLL 353
+ T E L++ + L E L+L E +E T +D + +
Sbjct: 219 CV--------------TFDESLLEEGEPL---EPGELQLNELTVESVQHTLTSVTDELAV 261
Query: 354 LSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSME 413
TE F Q E++ Q QE + N EE+ E
Sbjct: 262 ------------------ATEMVFRRQ-EMVTQLQQE--------LRNEEENTHP---RE 291
Query: 414 RKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQEL 473
R + L K + ++ ++ G+ + S A +++ + L + + + +
Sbjct: 292 RVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHST 351
Query: 474 LKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYT 533
+ + RE P +L + G R N+YR EG GF +IP LIDH +
Sbjct: 352 SSSEQE---REGGRTPTLEILKSHISGIFR----PKFSNLYRLEGEGFPSIPLLIDHLLS 404
Query: 534 TKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKT 592
T+Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+
Sbjct: 405 TQQPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS 463
Query: 593 CKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRK 652
C+E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 464 CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE 523
Query: 653 KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGG 712
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E G
Sbjct: 524 GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 583
Query: 713 VYSSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQARE 771
VY++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE
Sbjct: 584 VYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 643
Query: 772 QVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
VE+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 644 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 692
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 289 bits (739), Expect = 8e-78
Identities = 151/372 (40%), Positives = 228/372 (61%), Gaps = 16/372 (4%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASD 181
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQ-VIT-------KKSGVVLLNPIPKDKKWILSHED 562
+Y + F+ + +L+ HH T +IT K++ + P KW + D
Sbjct: 182 GKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTD 241
Query: 563 VILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIV 621
+ + LG G +GEVY+G K + +VAVKT KED E++ +FL+EA ++K+ HPN+V
Sbjct: 242 ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPNLV 299
Query: 622 KLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESKNC 680
+L+GVCT+ P YII E ++ G+ L +LR + E+ L+ + ++ M YLE KN
Sbjct: 300 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 359
Query: 681 IHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSE 740
IHRDLAARNCLVGEN+++K++DFG+SR G Y++ + PIKWTAPE+L Y ++S +
Sbjct: 360 IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK 419
Query: 741 SDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYK 800
SDVW+FG+LLWE + G+ PYPG+ Q E +E+ YRM P+ CPE + ++M CW +
Sbjct: 420 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWN 479
Query: 801 PENRPKFSELQK 812
P +RP F+E+ +
Sbjct: 480 PSDRPSFAEIHQ 491
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 289 bits (739), Expect = 8e-78
Identities = 151/372 (40%), Positives = 228/372 (61%), Gaps = 16/372 (4%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 141 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASD 200
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQ-VIT-------KKSGVVLLNPIPKDKKWILSHED 562
+Y + F+ + +L+ HH T +IT K++ + P KW + D
Sbjct: 201 GKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTD 260
Query: 563 VILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIV 621
+ + LG G +GEVY+G K + +VAVKT KED E++ +FL+EA ++K+ HPN+V
Sbjct: 261 ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPNLV 318
Query: 622 KLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESKNC 680
+L+GVCT+ P YII E ++ G+ L +LR + E+ L+ + ++ M YLE KN
Sbjct: 319 QLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 378
Query: 681 IHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSE 740
IHRDLAARNCLVGEN+++K++DFG+SR G Y++ + PIKWTAPE+L Y ++S +
Sbjct: 379 IHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIK 438
Query: 741 SDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYK 800
SDVW+FG+LLWE + G+ PYPG+ Q E +E+ YRM P+ CPE + ++M CW +
Sbjct: 439 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWN 498
Query: 801 PENRPKFSELQK 812
P +RP F+E+ +
Sbjct: 499 PSDRPSFAEIHQ 510
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 281 bits (718), Expect = 2e-75
Identities = 151/371 (40%), Positives = 222/371 (59%), Gaps = 20/371 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQVIT----------KKSGVVLLNPIPKDKKWILSH 560
+Y + FS + +L+ HH T + K V ++PI KW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI--HDKWEMER 270
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPN 619
D+ + LG G +GEVY G K + +VAVKT KED E++ +FL+EA ++K+ HPN
Sbjct: 271 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPN 328
Query: 620 IVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESK 678
+V+L+GVCT P YI+ E + G+ L +LR ++E+ L+ + ++ M YLE K
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738
N IHRDLAARNCLVGEN+V+K++DFG+SR G Y++ + PIKWTAPE+L Y +S
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD 798
+SDVW+FG+LLWE + G+ PYPG+ Q + +E+GYRM P+ CP + ++M CW
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 799 YKPENRPKFSE 809
+ P +RP F+E
Sbjct: 509 WSPADRPSFAE 519
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 281 bits (718), Expect = 2e-75
Identities = 151/371 (40%), Positives = 222/371 (59%), Gaps = 20/371 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQVIT----------KKSGVVLLNPIPKDKKWILSH 560
+Y + FS + +L+ HH T + K V ++PI KW +
Sbjct: 228 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI--HDKWEMER 285
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPN 619
D+ + LG G +GEVY G K + +VAVKT KED E++ +FL+EA ++K+ HPN
Sbjct: 286 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPN 343
Query: 620 IVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESK 678
+V+L+GVCT P YI+ E + G+ L +LR ++E+ L+ + ++ M YLE K
Sbjct: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
Query: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738
N IHRDLAARNCLVGEN+V+K++DFG+SR G Y++ + PIKWTAPE+L Y +S
Sbjct: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
Query: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD 798
+SDVW+FG+LLWE + G+ PYPG+ Q + +E+GYRM P+ CP + ++M CW
Sbjct: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
Query: 799 YKPENRPKFSE 809
+ P +RP F+E
Sbjct: 524 WSPADRPSFAE 534
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 281 bits (718), Expect = 2e-75
Identities = 151/371 (40%), Positives = 222/371 (59%), Gaps = 20/371 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQVIT----------KKSGVVLLNPIPKDKKWILSH 560
+Y + FS + +L+ HH T + K V ++PI KW +
Sbjct: 207 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI--HDKWEMER 264
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPN 619
D+ + LG G +GEVY G K + +VAVKT KED E++ +FL+EA ++K+ HPN
Sbjct: 265 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPN 322
Query: 620 IVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESK 678
+V+L+GVCT P YI+ E + G+ L +LR ++E+ L+ + ++ M YLE K
Sbjct: 323 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 382
Query: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738
N IHRDLAARNCLVGEN+V+K++DFG+SR G Y++ + PIKWTAPE+L Y +S
Sbjct: 383 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 442
Query: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD 798
+SDVW+FG+LLWE + G+ PYPG+ Q + +E+GYRM P+ CP + ++M CW
Sbjct: 443 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 502
Query: 799 YKPENRPKFSE 809
+ P +RP F+E
Sbjct: 503 WSPADRPSFAE 513
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 281 bits (718), Expect = 2e-75
Identities = 151/371 (40%), Positives = 222/371 (59%), Gaps = 20/371 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQVIT----------KKSGVVLLNPIPKDKKWILSH 560
+Y + FS + +L+ HH T + K V ++PI KW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI--HDKWEMER 270
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPN 619
D+ + LG G +GEVY G K + +VAVKT KED E++ +FL+EA ++K+ HPN
Sbjct: 271 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPN 328
Query: 620 IVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESK 678
+V+L+GVCT P YI+ E + G+ L +LR ++E+ L+ + ++ M YLE K
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738
N IHRDLAARNCLVGEN+V+K++DFG+SR G Y++ + PIKWTAPE+L Y +S
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD 798
+SDVW+FG+LLWE + G+ PYPG+ Q + +E+GYRM P+ CP + ++M CW
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 799 YKPENRPKFSE 809
+ P +RP F+E
Sbjct: 509 WSPADRPSFAE 519
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 281 bits (718), Expect = 2e-75
Identities = 151/371 (40%), Positives = 222/371 (59%), Gaps = 20/371 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKK--QGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 512
L + WYHG + R A+ LL G FLVRES PG+ +S+ +G+ H+ I +
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 191
Query: 513 --MYRFEGTGFSNIPQLIDHHYTTKQVIT----------KKSGVVLLNPIPKDKKWILSH 560
+Y + FS + +L+ HH T + K V ++PI KW +
Sbjct: 192 GKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPI--HDKWEMER 249
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKT-SVAVKTCKEDLPQELKIKFLQEAKILKQYDHPN 619
D+ + LG G +GEVY G K + +VAVKT KED E++ +FL+EA ++K+ HPN
Sbjct: 250 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-MEVE-EFLKEAAVMKEIKHPN 307
Query: 620 IVKLIGVCTQRQPVYIIMELVSGGDFLTFLRR-KKDELKLKQLVKFSLDAAAGMLYLESK 678
+V+L+GVCT P YI+ E + G+ L +LR ++E+ L+ + ++ M YLE K
Sbjct: 308 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
Query: 679 NCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYS 738
N IHRDLAARNCLVGEN+V+K++DFG+SR G Y++ + PIKWTAPE+L Y +S
Sbjct: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
Query: 739 SESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD 798
+SDVW+FG+LLWE + G+ PYPG+ Q + +E+GYRM P+ CP + ++M CW
Sbjct: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
Query: 799 YKPENRPKFSE 809
+ P +RP F+E
Sbjct: 488 WSPADRPSFAE 498
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 264 bits (674), Expect = 3e-70
Identities = 162/418 (38%), Positives = 239/418 (57%), Gaps = 26/418 (6%)
Query: 409 VTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPR 467
VT +E E S + ++H +G + L + AL + ++S P L+ W+HG I
Sbjct: 34 VTILEACENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISG 88
Query: 468 IEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNI 524
EA + L+ + G FLVRES PG+YVL V H+ + + D E F N+
Sbjct: 89 QEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNL 148
Query: 525 PQLIDHHYTTKQVIT-------KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEV 577
+++H+ K I +K G W+L+ + + LG +G+G FG V
Sbjct: 149 MDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAV 208
Query: 578 YKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIM 637
+G + VAVK K D+ + FL E ++ + H N+V+L+GV Q +YI+M
Sbjct: 209 LQGEYLGQ-KVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGVILH-QGLYIVM 263
Query: 638 ELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENN 696
E VS G+ + FLR R + + QL++FSL A GM YLESK +HRDLAARN LV E+
Sbjct: 264 EHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDL 323
Query: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756
V K+SDFG+++ E G+ SS ++P+KWTAPEAL +G+++S+SDVWSFG+LLWE FS
Sbjct: 324 VAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 379
Query: 757 GVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
G PYP M+ ++ E VE+GYRM P+ CP + +M CW+ +P RP F +L ++L
Sbjct: 380 GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 264 bits (674), Expect = 3e-70
Identities = 162/418 (38%), Positives = 239/418 (57%), Gaps = 26/418 (6%)
Query: 409 VTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPR 467
VT +E E S + ++H +G + L + AL + ++S P L+ W+HG I
Sbjct: 76 VTILEACENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISG 130
Query: 468 IEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNI 524
EA + L+ + G FLVRES PG+YVL V H+ + + D E F N+
Sbjct: 131 QEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNL 190
Query: 525 PQLIDHHYTTKQVIT-------KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEV 577
+++H+ K I +K G W+L+ + + LG +G+G FG V
Sbjct: 191 MDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAV 250
Query: 578 YKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIM 637
+G + VAVK K D+ + FL E ++ + H N+V+L+GV Q +YI+M
Sbjct: 251 LQGEYLGQ-KVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGVILH-QGLYIVM 305
Query: 638 ELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENN 696
E VS G+ + FLR R + + QL++FSL A GM YLESK +HRDLAARN LV E+
Sbjct: 306 EHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDL 365
Query: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756
V K+SDFG+++ E G+ SS ++P+KWTAPEAL +G+++S+SDVWSFG+LLWE FS
Sbjct: 366 VAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 421
Query: 757 GVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
G PYP M+ ++ E VE+GYRM P+ CP + +M CW+ +P RP F +L ++L
Sbjct: 422 GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 264 bits (674), Expect = 3e-70
Identities = 162/418 (38%), Positives = 239/418 (57%), Gaps = 26/418 (6%)
Query: 409 VTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPR 467
VT +E E S + ++H +G + L + AL + ++S P L+ W+HG I
Sbjct: 75 VTILEACENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISG 129
Query: 468 IEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNI 524
EA + L+ + G FLVRES PG+YVL V H+ + + D E F N+
Sbjct: 130 QEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNL 189
Query: 525 PQLIDHHYTTKQVIT-------KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEV 577
+++H+ K I +K G W+L+ + + LG +G+G FG V
Sbjct: 190 MDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAV 249
Query: 578 YKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIM 637
+G + VAVK K D+ + FL E ++ + H N+V+L+GV Q +YI+M
Sbjct: 250 LQGEYLGQ-KVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGVILH-QGLYIVM 304
Query: 638 ELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENN 696
E VS G+ + FLR R + + QL++FSL A GM YLESK +HRDLAARN LV E+
Sbjct: 305 EHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDL 364
Query: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756
V K+SDFG+++ E G+ SS ++P+KWTAPEAL +G+++S+SDVWSFG+LLWE FS
Sbjct: 365 VAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 420
Query: 757 GVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
G PYP M+ ++ E VE+GYRM P+ CP + +M CW+ +P RP F +L ++L
Sbjct: 421 GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 478
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 259 bits (663), Expect = 5e-69
Identities = 151/422 (35%), Positives = 229/422 (54%), Gaps = 20/422 (4%)
Query: 411 SMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEA 470
S+ R +RL E I S + + G ++ + S + L++Q WY + R +A
Sbjct: 71 SVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQA 130
Query: 471 QELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYV--DNMYRFEGTGFSNI 524
Q+LL + G FL+R S G Y LSV + + H+ + ++Y +G F +
Sbjct: 131 QQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGL 190
Query: 525 PQLIDHHYTTKQVITKKSGVVLLNPI-----PKDKKWILSHEDVILGELLGKGNFGEVYK 579
+L+ ++ ++I LL P P+ W H + LG LG+G FGEV++
Sbjct: 191 EELLTYYKANWKLIQNP----LLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWE 246
Query: 580 GTLKDKTSVAVKTCKEDLPQELKIKFL-QEAKILKQYDHPNIVKLIGVCTQRQPVYIIME 638
G VA+K K +K+ L +E + LK H +++L VC+ +PVYI+ E
Sbjct: 247 GLWLGSLPVAIKVIKS---ANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTE 303
Query: 639 LVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNV 697
L+ G+ FL + L+L L+ F+ A GM YLE + +HRDLAARN LV +
Sbjct: 304 LMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLA 363
Query: 698 LKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLG 757
K++DFG++R +YS S +IP+KWTAPEA NY +S +SDVWSFG+LL E F+ G
Sbjct: 364 CKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYG 423
Query: 758 VCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTII 817
CPY GMTN + +Q+ RGYR+ P CP ++ +M++CW PE RP F+ L+++L I
Sbjct: 424 QCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAI 483
Query: 818 KR 819
R
Sbjct: 484 HR 485
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 258 bits (660), Expect = 1e-68
Identities = 145/384 (37%), Positives = 219/384 (57%), Gaps = 25/384 (6%)
Query: 452 EKPLAEQDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII 507
++ L + W+ GAI R +A++ L K G FL+RES + GE+ LSV +H+ I
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRI 167
Query: 508 QYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLN---PIPKD------KKW 556
+ +D + FS + + + H+ T + K G L P P D +W
Sbjct: 168 KRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQW 227
Query: 557 ILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDL--PQELKIKFLQEAKILKQ 614
+ + L + LG G FGEV++G + T VAVKT K P + FL+EA+I+K
Sbjct: 228 EIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPND----FLREAQIMKN 283
Query: 615 YDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK-DELKLKQLVKFSLDAAAGML 673
HP +++L VCT P+YII EL+ G +L+ ++ L Q V + A+GM
Sbjct: 284 LRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMA 343
Query: 674 YLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ---EDGGVYSSSGLKQIPIKWTAPE 730
YLES+N IHRDLAARN LVGE+N+ K++DFG++R ++ +Y S ++P+KWTAPE
Sbjct: 344 YLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPE 403
Query: 731 ALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDIS 790
A+ ++S +SDVWSFGILL+E + G PY GMT Q + + + YR+ P +CP+
Sbjct: 404 AIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 791 KIMMKCWDYKPENRPKFSELQKEL 814
IM++CW+ +P+ RP F L+ +L
Sbjct: 464 NIMLECWNAEPKERPTFETLRWKL 487
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 253 bits (647), Expect = 4e-67
Identities = 154/385 (40%), Positives = 224/385 (58%), Gaps = 23/385 (5%)
Query: 445 SDMISISEKPLAEQDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYS-D 499
S+ ++ S+ AE+ WY G I R E++ LL +G FLVRES G Y LSV D
Sbjct: 137 SNYVAPSDSIQAEE-WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 195
Query: 500 GQR----RHFIIQYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 553
+ +H+ I+ +D+ Y T F+++ QL+ ++ + + V P+
Sbjct: 196 NAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT 255
Query: 554 K-----KWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIK-FLQ 607
+ W + E + L LG+G FGEV+ GT T VA+KT K P + + FLQ
Sbjct: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK---PGTMSPEAFLQ 312
Query: 608 EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSL 666
EA+++K+ H +V+L V ++ +P+YI+ E +S G L FL+ + + L+L QLV +
Sbjct: 313 EAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371
Query: 667 DAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKW 726
A+GM Y+E N +HRDL A N LVGEN V K++DFG++R + Y++ + PIKW
Sbjct: 372 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431
Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCP 786
TAPEA YGR++ +SDVWSFGILL E + G PYPGM N++ +QVERGYRM P CP
Sbjct: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491
Query: 787 EDISKIMMKCWDYKPENRPKFSELQ 811
E + +M +CW +PE RP F LQ
Sbjct: 492 ESLHDLMCQCWRKEPEERPTFEYLQ 516
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 253 bits (647), Expect = 4e-67
Identities = 154/385 (40%), Positives = 224/385 (58%), Gaps = 23/385 (5%)
Query: 445 SDMISISEKPLAEQDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYS-D 499
S+ ++ S+ AE+ WY G I R E++ LL +G FLVRES G Y LSV D
Sbjct: 137 SNYVAPSDSIQAEE-WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 195
Query: 500 GQR----RHFIIQYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 553
+ +H+ I+ +D+ Y T F+++ QL+ ++ + + V P+
Sbjct: 196 NAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT 255
Query: 554 K-----KWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIK-FLQ 607
+ W + E + L LG+G FGEV+ GT T VA+KT K P + + FLQ
Sbjct: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK---PGTMSPEAFLQ 312
Query: 608 EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSL 666
EA+++K+ H +V+L V ++ +P+YI+ E +S G L FL+ + + L+L QLV +
Sbjct: 313 EAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371
Query: 667 DAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKW 726
A+GM Y+E N +HRDL A N LVGEN V K++DFG++R + Y++ + PIKW
Sbjct: 372 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431
Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCP 786
TAPEA YGR++ +SDVWSFGILL E + G PYPGM N++ +QVERGYRM P CP
Sbjct: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491
Query: 787 EDISKIMMKCWDYKPENRPKFSELQ 811
E + +M +CW +PE RP F LQ
Sbjct: 492 ESLHDLMCQCWRKEPEERPTFEYLQ 516
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 253 bits (647), Expect = 4e-67
Identities = 165/437 (37%), Positives = 238/437 (54%), Gaps = 28/437 (6%)
Query: 399 VVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSAL--SDMISISEKPLA 456
V Y+ +AR+ + K+ +F+ I ++ + A G + S+ ++ ++ A
Sbjct: 97 VALYDYEARTTEDLSFKKG-ERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQA 155
Query: 457 EQDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRR-----HFII 507
E+ WY G + R +A+ LL ++G FLVRES G Y LS+ + R H+ I
Sbjct: 156 EE-WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
Query: 508 QYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDK-----KWILSH 560
+ +DN Y F + +L+ H+ + K V P+ + W +
Sbjct: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
Query: 561 EDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKED--LPQELKIKFLQEAKILKQYDHP 618
E + L LG+G FGEV+ GT T VA+KT K +P+ FLQEA+I+K+ H
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEA----FLQEAQIMKKLRHD 330
Query: 619 NIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGMLYLES 677
+V L V ++ +P+YI+ E +S G L FL+ + LKL QLV + A GM Y+E
Sbjct: 331 KLVPLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER 389
Query: 678 KNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRY 737
N IHRDL A N LVGEN V KI+DFG++R + Y++ + PIKWTAPEA YGR+
Sbjct: 390 MNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 449
Query: 738 SSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCW 797
+ +SDVWSFGIL E + G PYPGM N++ EQVERGYRM PQ CPE + ++M CW
Sbjct: 450 TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 509
Query: 798 DYKPENRPKFSELQKEL 814
P+ RP F +Q L
Sbjct: 510 KKDPDERPTFEYIQSFL 526
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 253 bits (646), Expect = 5e-67
Identities = 145/377 (38%), Positives = 215/377 (57%), Gaps = 21/377 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELLKKQGD----FLVRESHGKPGEYVLSVYSDGQR-----RHF 505
L ++W+ I R +A+ L G+ F++R+S G Y LSV R +H+
Sbjct: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHY 198
Query: 506 IIQYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDK----KWILS 559
I+ +DN Y + FS + +L+DH+ + +K V ++ P+ W +
Sbjct: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP 258
Query: 560 HEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIK-FLQEAKILKQYDHP 618
E + L + LG G FGEV+ T T VAVKT K P + ++ FL EA ++K H
Sbjct: 259 RESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK---PGSMSVEAFLAEANVMKTLQHD 315
Query: 619 NIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELK-LKQLVKFSLDAAAGMLYLES 677
+VKL V T ++P+YII E ++ G L FL+ + + L +L+ FS A GM ++E
Sbjct: 316 KLVKLHAVVT-KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQ 374
Query: 678 KNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRY 737
+N IHRDL A N LV + V KI+DFG++R + Y++ + PIKWTAPEA+N+G +
Sbjct: 375 RNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSF 434
Query: 738 SSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCW 797
+ +SDVWSFGILL E + G PYPGM+N + +ERGYRM P++CPE++ IMM+CW
Sbjct: 435 TIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCW 494
Query: 798 DYKPENRPKFSELQKEL 814
+PE RP F +Q L
Sbjct: 495 KNRPEERPTFEYIQSVL 511
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 251 bits (641), Expect = 2e-66
Identities = 153/383 (39%), Positives = 215/383 (56%), Gaps = 24/383 (6%)
Query: 450 ISEKPLAEQD-WYHGAIPRIEAQELLKKQGD----FLVRESHGKPGEYVLSVYSDGQRRH 504
++E+ E + W+ G I R EA L+ +G+ FL+R S +YVLSV RH
Sbjct: 67 LAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRH 126
Query: 505 FII--QYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLL--------NPIPKDK 554
+ I + ++ E F ++P+L+++H + + G+ L P+P
Sbjct: 127 YKIWRRAGGRLHLNEAVSFLSLPELVNYH----RAQSLSHGLRLAAPCRKHEPEPLPHWD 182
Query: 555 KWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQ-EAKILK 613
W E+ L LG G FGEV++G KD+ VA+K D L + LQ E + +K
Sbjct: 183 DWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRD--NLLHQQMLQSEIQAMK 240
Query: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGM 672
+ H +I+ L V + PVYII EL++ G L LR ++ L + +L+ + A GM
Sbjct: 241 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM 300
Query: 673 LYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEAL 732
YLES+N IHRDLAARN LVGEN + K+ DFG++R VY S IP KWTAPEAL
Sbjct: 301 CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTAPEAL 359
Query: 733 NYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKI 792
+ G YS++SDVWSFGILL E FS G PYPGM+N +A +V+ GYRM P CP + K+
Sbjct: 360 SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKL 419
Query: 793 MMKCWDYKPENRPKFSELQKELT 815
M+ CW PE RP F L++ L+
Sbjct: 420 MLTCWCRDPEQRPCFKALRERLS 442
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 249 bits (635), Expect = 1e-65
Identities = 149/391 (38%), Positives = 217/391 (55%), Gaps = 22/391 (5%)
Query: 449 SISEKPLAEQDWYHGAIPRIEAQELLK---KQGDFLVRESHGKPGEYVLSVYSD------ 499
S E+ L + DW+ G I R ++++LL+ K+G F+VR S + G Y +S++S
Sbjct: 285 SEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKK 343
Query: 500 GQRRHFIIQY--VDNMYRFEGTGFSNIPQLIDHH-YTTKQVITKKSGVVLL--NPIPKDK 554
G +H+ + + +Y E F +IP+LI +H + + +IT+ V N +P
Sbjct: 344 GTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSV 403
Query: 555 K-----WILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEA 609
W L E++ L + LG G FG V G K + VAVK KE E +F QEA
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSE--DEFFQEA 461
Query: 610 KILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAA 669
+ + + HP +VK GVC++ P+YI+ E +S G L +LR L+ QL++ D
Sbjct: 462 QTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVC 521
Query: 670 AGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAP 729
GM +LES IHRDLAARNCLV + +K+SDFGM+R Y SS + P+KW+AP
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAP 581
Query: 730 EALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDI 789
E +Y +YSS+SDVW+FGIL+WE FSLG PY N Q +V +G+R+ P + I
Sbjct: 582 EVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTI 641
Query: 790 SKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
+IM CW PE RP F +L + ++ K
Sbjct: 642 YQIMYSCWHELPEKRPTFQQLLSSIEPLREK 672
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 249 bits (635), Expect = 1e-65
Identities = 149/391 (38%), Positives = 217/391 (55%), Gaps = 22/391 (5%)
Query: 449 SISEKPLAEQDWYHGAIPRIEAQELLK---KQGDFLVRESHGKPGEYVLSVYSD------ 499
S E+ L + DW+ G I R ++++LL+ K+G F+VR S + G Y +S++S
Sbjct: 285 SEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKK 343
Query: 500 GQRRHFIIQY--VDNMYRFEGTGFSNIPQLIDHH-YTTKQVITKKSGVVLL--NPIPKDK 554
G +H+ + + +Y E F +IP+LI +H + + +IT+ V N +P
Sbjct: 344 GTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSV 403
Query: 555 K-----WILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEA 609
W L E++ L + LG G FG V G K + VAVK KE E +F QEA
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSE--DEFFQEA 461
Query: 610 KILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAA 669
+ + + HP +VK GVC++ P+YI+ E +S G L +LR L+ QL++ D
Sbjct: 462 QTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVC 521
Query: 670 AGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAP 729
GM +LES IHRDLAARNCLV + +K+SDFGM+R Y SS + P+KW+AP
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAP 581
Query: 730 EALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDI 789
E +Y +YSS+SDVW+FGIL+WE FSLG PY N Q +V +G+R+ P + I
Sbjct: 582 EVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTI 641
Query: 790 SKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
+IM CW PE RP F +L + ++ K
Sbjct: 642 YQIMYSCWHELPEKRPTFQQLLSSIEPLREK 672
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 248 bits (633), Expect = 2e-65
Identities = 145/376 (38%), Positives = 213/376 (56%), Gaps = 20/376 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELL--KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY-VD 511
L+ W+HG I R +A+ LL + G FLVRES PG+Y L V DG+ H+ I Y
Sbjct: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS 136
Query: 512 NMYRFEGTGFSNIPQLIDHHYTTKQVITKK-------SGVVLLNPIPKDKKWILSHEDVI 564
+ E F N+ QL++H+ + + + G V W L+ +++
Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELK 196
Query: 565 LGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLI 624
L + +GKG FG+V G + VAVK K D + FL EA ++ Q H N+V+L+
Sbjct: 197 LLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLL 252
Query: 625 GVCTQRQP-VYIIMELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIH 682
GV + + +YI+ E ++ G + +LR R + L L+KFSLD M YLE N +H
Sbjct: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312
Query: 683 RDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESD 742
RDLAARN LV E+NV K+SDFG++++ S+ ++P+KWTAPEAL ++S++SD
Sbjct: 313 RDLAARNVLVSEDNVAKVSDFGLTKEAS----STQDTGKLPVKWTAPEALREKKFSTKSD 368
Query: 743 VWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPE 802
VWSFGILLWE +S G PYP + + +VE+GY+M AP CP + ++M CW
Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAA 428
Query: 803 NRPKFSELQKELTIIK 818
RP F +L+++L IK
Sbjct: 429 MRPSFLQLREQLEHIK 444
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 248 bits (633), Expect = 2e-65
Identities = 145/376 (38%), Positives = 213/376 (56%), Gaps = 20/376 (5%)
Query: 455 LAEQDWYHGAIPRIEAQELL--KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY-VD 511
L+ W+HG I R +A+ LL + G FLVRES PG+Y L V DG+ H+ I Y
Sbjct: 77 LSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS 136
Query: 512 NMYRFEGTGFSNIPQLIDHHYTTKQVITKK-------SGVVLLNPIPKDKKWILSHEDVI 564
+ E F N+ QL++H+ + + + G V W L+ +++
Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELK 196
Query: 565 LGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLI 624
L + +GKG FG+V G + VAVK K D + FL EA ++ Q H N+V+L+
Sbjct: 197 LLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA---FLAEASVMTQLRHSNLVQLL 252
Query: 625 GVCTQRQP-VYIIMELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIH 682
GV + + +YI+ E ++ G + +LR R + L L+KFSLD M YLE N +H
Sbjct: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312
Query: 683 RDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESD 742
RDLAARN LV E+NV K+SDFG++++ S+ ++P+KWTAPEAL ++S++SD
Sbjct: 313 RDLAARNVLVSEDNVAKVSDFGLTKEAS----STQDTGKLPVKWTAPEALREKKFSTKSD 368
Query: 743 VWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPE 802
VWSFGILLWE +S G PYP + + +VE+GY+M AP CP + ++M CW
Sbjct: 369 VWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAA 428
Query: 803 NRPKFSELQKELTIIK 818
RP F +L+++L IK
Sbjct: 429 MRPSFLQLREQLEHIK 444
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 247 bits (631), Expect = 3e-65
Identities = 148/377 (39%), Positives = 209/377 (55%), Gaps = 23/377 (6%)
Query: 458 QDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYS-DGQR----RHFIIQ 508
++WY G + R +A+ L +G FL+RES G Y LS+ D + +H+ I+
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIR 206
Query: 509 YVDN--MYRFEGTGFSNIPQLIDHH------YTTKQVITKKSGVVLLNPIPKDKK--WIL 558
+DN Y F + QL+ H+ + V+ G+ L + K W +
Sbjct: 207 KLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEI 266
Query: 559 SHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHP 618
E + L + LG G FGEV+ GT T VA+KT K FL+EA+I+K+ H
Sbjct: 267 PRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPES--FLEEAQIMKKLKHD 324
Query: 619 NIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDE-LKLKQLVKFSLDAAAGMLYLES 677
+V+L V ++ +P+YI+ E ++ G L FL+ + LKL LV + AAGM Y+E
Sbjct: 325 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 383
Query: 678 KNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRY 737
N IHRDL + N LVG + KI+DFG++R + Y++ + PIKWTAPEA YGR+
Sbjct: 384 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 443
Query: 738 SSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCW 797
+ +SDVWSFGILL E + G PYPGM N++ EQVERGYRM PQ CP + ++M+ CW
Sbjct: 444 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 503
Query: 798 DYKPENRPKFSELQKEL 814
PE RP F LQ L
Sbjct: 504 KKDPEERPTFEYLQSFL 520
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 246 bits (628), Expect = 6e-65
Identities = 137/389 (35%), Positives = 215/389 (55%), Gaps = 30/389 (7%)
Query: 445 SDMISISEKPLAEQDWYHGAIPRIEAQELLK---KQGDFLVRESHGKPGEYVLSVYS--- 498
S+ ++ +E + +WY + R +A++LLK K+G F+VR+S K G+Y +SV++
Sbjct: 266 SNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKST 324
Query: 499 ---DGQRRHFIIQYV--DNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 553
G RH+++ Y E FS IP+LI++H + + L P+ +
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISR----LKYPVSQQ 380
Query: 554 KK------------WILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQEL 601
K W + +D+ + LG G FG V G + + VA+K KE E
Sbjct: 381 NKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE- 439
Query: 602 KIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQL 661
+F++EAK++ H +V+L GVCT+++P++II E ++ G L +LR + + +QL
Sbjct: 440 -DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQL 498
Query: 662 VKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQ 721
++ D M YLESK +HRDLAARNCLV + V+K+SDFG+SR Y+SS +
Sbjct: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
Query: 722 IPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSA 781
P++W+ PE L Y ++SS+SD+W+FG+L+WE +SLG PY TN + E + +G R+
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
Query: 782 PQHCPEDISKIMMKCWDYKPENRPKFSEL 810
P E + IM CW K + RP F L
Sbjct: 619 PHLASEKVYTIMYSCWHEKADERPTFKIL 647
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 245 bits (626), Expect = 1e-64
Identities = 146/404 (36%), Positives = 220/404 (54%), Gaps = 25/404 (6%)
Query: 436 KSALGSSALSDMISISEKPLAE---QDWYHGAIPRIEAQELLK---KQGDFLVRESHGKP 489
+ LG+ L ++E + +WYH I R +A+ LL+ K+G F+VR+S
Sbjct: 123 RDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL- 181
Query: 490 GEYVLSVYSDGQR------RHFIIQYVDN--MYRFEGTGFSNIPQLIDHH-YTTKQVITK 540
G Y +SV+ +R +H+ I+ D+ Y E F +IP+LI +H + ++T+
Sbjct: 182 GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTR 241
Query: 541 KSGVVLL--NPIPKD-----KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTC 593
V L + +P +KW + ++ + +G G FG V+ G + VA+K
Sbjct: 242 LRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAI 301
Query: 594 KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK 653
E E F++EAK++ + H +V+L GVC QR+P+YI+ E + G L +LR K
Sbjct: 302 NEGSMSEED--FIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENK 359
Query: 654 DELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGV 713
+L+ + L+ D GM YLE IHRDLAARNCLV ++KISDFGM+R
Sbjct: 360 GKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDE 419
Query: 714 YSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV 773
Y SS + PIKW+ PE + +YSS+SDVWSFG+L+WE F+ G P+ +N Q E +
Sbjct: 420 YVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI 479
Query: 774 ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTII 817
G+R+ P P I ++M CW KPE RP F+EL + +T I
Sbjct: 480 SEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 245 bits (625), Expect = 1e-64
Identities = 139/381 (36%), Positives = 215/381 (56%), Gaps = 24/381 (6%)
Query: 455 LAEQDWYHGAIPRIEAQELLK---KQGDFLVRESHGKPGEYVLSVY-------SDGQRRH 504
L + +WY + R +A++LL+ K+G F+VR+S +PG Y +S+Y S G R +
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHY 300
Query: 505 FIIQYVDN---MYRFEGTGFSNIPQLIDHH-YTTKQVITKKSGVVLLN----PIPKD--- 553
I + + Y E F +IP++I++H + ++T+ V + P
Sbjct: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360
Query: 554 KKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILK 613
+KW ++ ++ LG G FG V G + + VA+K +E E F++EAK++
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEED--FIEEAKVMM 418
Query: 614 QYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGML 673
+ HP +V+L GVCTQ++P+YI+ E + G L FLR+++ L+ D GM
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 674 YLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALN 733
YLE + IHRDLAARNCLV E V+K+SDFGM+R Y+SS + P+KW PE N
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Query: 734 YGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIM 793
Y R+SS+SDVWSFG+L+WE F+ G P+ TN + V RG+R+ P+ + ++M
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
Query: 794 MKCWDYKPENRPKFSELQKEL 814
++CW KPE RP F +L + +
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTI 619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,901,454
Number of Sequences: 37866
Number of extensions: 1272355
Number of successful extensions: 9650
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 666
Number of HSP's successfully gapped in prelim test: 851
Number of HSP's that attempted gapping in prelim test: 5507
Number of HSP's gapped (non-prelim): 2834
length of query: 822
length of database: 18,247,518
effective HSP length: 111
effective length of query: 711
effective length of database: 14,044,392
effective search space: 9985562712
effective search space used: 9985562712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.