Search of human proteins with 119120884

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119120884 fer-1-like 6 [Homo sapiens]
         (1857 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119120884 fer-1-like 6 [Homo sapiens]                             3777   0.0  
gi|34740331 otoferlin isoform a [Homo sapiens]                       1803   0.0  
gi|35493853 otoferlin isoform c [Homo sapiens]                       1261   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                       1246   0.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                       1240   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                       720   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                       720   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                       720   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                      720   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                      720   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                      720   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                       709   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                         709   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                       709   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                       709   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                       709   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                      709   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                      709   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                       709   0.0  
gi|19718759 myoferlin isoform b [Homo sapiens]                        689   0.0  
gi|7305053 myoferlin isoform a [Homo sapiens]                         689   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    426   e-118
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                    418   e-116
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 60   3e-08
gi|238550198 synaptotagmin III [Homo sapiens]                          55   5e-07
gi|238550196 synaptotagmin III [Homo sapiens]                          55   5e-07
gi|14150054 synaptotagmin III [Homo sapiens]                           55   5e-07
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            55   6e-07
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            55   6e-07
gi|150170670 piccolo isoform 2 [Homo sapiens]                          54   1e-06

>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score = 3777 bits (9795), Expect = 0.0
 Identities = 1857/1857 (100%), Positives = 1857/1857 (100%)

Query: 1    MFGLKVKKKRNKAEKGLILANKAAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPS 60
            MFGLKVKKKRNKAEKGLILANKAAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPS
Sbjct: 1    MFGLKVKKKRNKAEKGLILANKAAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPS 60

Query: 61   ASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEG 120
            ASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEG
Sbjct: 61   ASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEG 120

Query: 121  TNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFC 180
            TNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFC
Sbjct: 121  TNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFC 180

Query: 181  NKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLER 240
            NKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLER
Sbjct: 181  NKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLER 240

Query: 241  PWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCA 300
            PWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCA
Sbjct: 241  PWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCA 300

Query: 301  DPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTF 360
            DPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTF
Sbjct: 301  DPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTF 360

Query: 361  GPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALK 420
            GPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALK
Sbjct: 361  GPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALK 420

Query: 421  ELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFL 480
            ELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFL
Sbjct: 421  ELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFL 480

Query: 481  LFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQ 540
            LFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQ
Sbjct: 481  LFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQ 540

Query: 541  GDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNML 600
            GDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNML
Sbjct: 541  GDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNML 600

Query: 601  EKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLD 660
            EKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLD
Sbjct: 601  EKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLD 660

Query: 661  KKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVF 720
            KKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVF
Sbjct: 661  KKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVF 720

Query: 721  IWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
            IWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY
Sbjct: 721  IWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780

Query: 781  LWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIA 840
            LWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIA
Sbjct: 781  LWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIA 840

Query: 841  ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
            ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV
Sbjct: 841  ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900

Query: 901  ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVP 960
            ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVP
Sbjct: 901  ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVP 960

Query: 961  PSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIE 1020
            PSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIE
Sbjct: 961  PSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIE 1020

Query: 1021 CGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTY 1080
            CGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTY
Sbjct: 1021 CGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTY 1080

Query: 1081 TINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVE 1140
            TINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVE
Sbjct: 1081 TINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVE 1140

Query: 1141 PPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
            PPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR
Sbjct: 1141 PPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
            TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK
Sbjct: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGK 1320
            MLKKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGK
Sbjct: 1261 MLKKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGK 1320

Query: 1321 FKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPY 1380
            FKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPY
Sbjct: 1321 FKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPY 1380

Query: 1381 IVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGET 1440
            IVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGET
Sbjct: 1381 IVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGET 1440

Query: 1441 KIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQ 1500
            KIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQ
Sbjct: 1441 KIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQ 1500

Query: 1501 IGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
            IGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK
Sbjct: 1501 IGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK
Sbjct: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
            SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS
Sbjct: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEET 1740
            LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEET
Sbjct: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEET 1740

Query: 1741 KISIFQQKRVRGWWPFSKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPD 1800
            KISIFQQKRVRGWWPFSKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPD
Sbjct: 1741 KISIFQQKRVRGWWPFSKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPD 1800

Query: 1801 TSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIVVGS 1857
            TSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIVVGS
Sbjct: 1801 TSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIVVGS 1857


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score = 1803 bits (4670), Expect = 0.0
 Identities = 921/1857 (49%), Positives = 1279/1857 (68%), Gaps = 140/1857 (7%)

Query: 53   ASIFPVPSASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEK 112
            AS+  + +    +RSK   K+     R  +YQ++IT+ EARQLVG N+DPVV +E+GD+K
Sbjct: 224  ASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDK 283

Query: 113  KQSTVKEGTNSPFYNEYFVFDF-IGPQVHLFDKIIKISVFHHK--LIGSVLIGSFKVDLG 169
            K +++KE TN P+YNEYFVFDF + P V +FDKIIKISV H K  L    L+GSFK+D+G
Sbjct: 284  KYTSMKESTNCPYYNEYFVFDFHVSPDV-MFDKIIKISVIHSKNLLRSGTLVGSFKMDVG 342

Query: 170  TVYNQPGHQFCNKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEP-IEK 228
            TVY+QP HQF +KWA+L+DP DI +G KGY+KCD++V+GKGD +KT  K ++T+E  IE 
Sbjct: 343  TVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEG 402

Query: 229  NLLIPNGFPLERPWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAG 288
            NLL+P G P ER WARFYV++Y+AEGLP+MN+S+MANV KAF+G++KDLVDP+V+V FAG
Sbjct: 403  NLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAG 462

Query: 289  QMGRTTVQKNCADPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISN 348
            Q G+T+VQK+  +P+W+EQV+F ++FPPLC+R+K+Q+ D   +NDVA+ THFIDL+KISN
Sbjct: 463  QKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISN 522

Query: 349  EQDGDKGFLPTFGPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSG 408
              DGDKGFLPT GPAW+N+YGS RN++L+D++Q++NEG GEGVSFR R+L+ +AVEI+  
Sbjct: 523  --DGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT 580

Query: 409  RAQESKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVP 468
               E                                          T+STEV+VE     
Sbjct: 581  SNPEL-----------------------------------------TSSTEVQVEQATPI 599

Query: 469  PEIVPEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSH-HGSKKSAES 527
             E    K EEF LFGAF EA+MIDR+ GDKPI+FEV+IGN+GN +DG S     +   E 
Sbjct: 600  SESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEP 659

Query: 528  AEEDLLPLLHEGQGDVAHDV-PIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISS 586
             +E+ + L+     D A D   +   S+T P +P VT+  RNY +LP+  +KPC+Y  S 
Sbjct: 660  GDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTD--RNYFHLPYLERKPCIYIKSW 717

Query: 587  WGDQTFRLHWSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISE 646
            W DQ  RL+ +N+++ +AD LEE + +++E+IK  +  PE +++ VL +       F+S 
Sbjct: 718  WPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSL 777

Query: 647  AEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIR 706
            A+K     ++T LD++RL  C +ELE M ++A+ +++ Q K+ +V + +   QNF++K+R
Sbjct: 778  ADKDQGHSSRTRLDRERLKSCMRELENMGQQAR-MLRAQVKRHTVRDKLRLCQNFLQKLR 836

Query: 707  FLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGK 766
            FL DEPQH+IPD+FIWM+SNN+RVAYAR+ SKDLL+S V  + GK C K+KT FLK PGK
Sbjct: 837  FLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGK 896

Query: 767  R---PAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTN-HPPSNLLYQE 822
            R    AGW+VQAKV++YLWLG  K     L  LP G++   +++G G +  PP +L+Y +
Sbjct: 897  RGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTK 956

Query: 823  QHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDL 882
            +  FQLRAHMYQAR L AADS+GLSDPFA+V F++  Q T+++++TL PTW+QML+F++L
Sbjct: 957  KQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNL 1016

Query: 883  VLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPR----LCYH 938
             L+G+  EL + PP++V+E+YD D++GK +++G T A P+VK+AD+ Y PPR    L Y+
Sbjct: 1017 ELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYY 1076

Query: 939  PIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPP---DITQIYPVPANIRPVLSKYRVE 995
             I+ GN + GDLLA FELLQ+ P+G   LPP+  P   D   I PVP  IRPVLSKYRVE
Sbjct: 1077 QIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVE 1136

Query: 996  VLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENE 1055
            VLFWG+R++K+V L  VDRP+  IEC G+GV+S +I +YK NPNF+     FEV+LPENE
Sbjct: 1137 VLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENE 1196

Query: 1056 LLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPI--TQVDGTQPGHDISD 1113
            LLHPPL+I VVD RAFGR TLVG++ ++ L++F+ +  +  AP   T V   +    + +
Sbjct: 1197 LLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCN 1256

Query: 1114 SLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTP 1173
              +++ S+G    + +P      V ++   T+V   A ++  + VDV +     + +   
Sbjct: 1257 GGSSSHSTGEVVVTMEPE-----VPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKG 1311

Query: 1174 VAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKA--------- 1224
             A+EP ++                       E  E+++DWWSKY+AS+            
Sbjct: 1312 TAEEPEEE-----------------------EPDESMLDWWSKYFASIDTMKEQLRQQEP 1348

Query: 1225 ------QKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKML----------KKKPKD 1268
                  +K +  N +G KG+ + K        E   KKKK +            KKKPK 
Sbjct: 1349 SGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEE---KKKKTQSSGSGQGSEAPEKKKPKI 1405

Query: 1269 DGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHG-LDGDRVIGKFKGSFCI 1327
            D       L++Y  +LESEF+NFEDW+ TF L RGK+ +D+ G  + +R++G+FKGS C+
Sbjct: 1406 DE------LKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCV 1459

Query: 1328 YKSP--QDSSSEDS--GQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVI 1383
            YK P  +D S E        + QGIP N P+ VL+RVY+V A +L PAD +GK+DPYI I
Sbjct: 1460 YKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAI 1519

Query: 1384 KLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKID 1443
            +LGKT+I+D++ YI KQLNPVFG+SF+I+A+FP ES+L++ +YD D++GTDDLIGETKID
Sbjct: 1520 RLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKID 1579

Query: 1444 LENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP-GKIQIG 1502
            LENRFYSKHRA CG+   Y   GYN WRD  KP++ILT+LCKD K+DGP+F P G++++ 
Sbjct: 1580 LENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVA 1639

Query: 1503 NQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPG 1562
            N+VF+G +   E++  +   + EH+AL  L  WEDIP  GCRLVPEH+ETRPL + DKPG
Sbjct: 1640 NRVFTGPSEI-EDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPG 1698

Query: 1563 MEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSS 1622
            +EQGRL++WVDMFP DMP PG P+DISPR+PK YELRV IWNT++V+LED++ FTG+KSS
Sbjct: 1699 IEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSS 1758

Query: 1623 DIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLE 1682
            DI+V+GWLKG ++DKQ+TDVHY+SLTGEGNFNWR+LFPF YL AE+++VI+K+E++FS +
Sbjct: 1759 DIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWD 1818

Query: 1683 KMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKI 1742
            + E K PA L LQ+WD +  S+DDFLG +E++LN FPR AK+AK C +       +   +
Sbjct: 1819 ETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLV 1878

Query: 1743 SIFQQKRVRGWWPF-----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPN 1797
            SIF+QKRV+GWWP      +   ELTGKVEAE HL+TAEEAEKNPVG AR EP+PL KPN
Sbjct: 1879 SIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPN 1938

Query: 1798 RPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
            RPDTSF WF++P K   Y +W  Y+  ++   +L++L++ L LF+Y++PG + ++I+
Sbjct: 1939 RPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score = 1261 bits (3263), Expect = 0.0
 Identities = 638/1299 (49%), Positives = 893/1299 (68%), Gaps = 88/1299 (6%)

Query: 605  DFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
            D  EE + +++E+IK  +  PE +++ VL +       F+S A+K     ++T LD++RL
Sbjct: 46   DSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERL 105

Query: 665  TLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWML 724
              C +ELE M ++A+ +++ Q K+ +V + +   QNF++K+RFL DEPQH+IPD+FIWM+
Sbjct: 106  KSCMRELENMGQQAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMM 164

Query: 725  SNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYL 781
            SNN+RVAYAR+ SKDLL+S V  + GK C K+KT FLK PGKR    AGW+VQAKV++YL
Sbjct: 165  SNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYL 224

Query: 782  WLGSIKHASAILDNLPVGYEAEMSSKGAGTN-HPPSNLLYQEQHVFQLRAHMYQARGLIA 840
            WLG  K     L  LP G++   +++G G +  PP +L+Y ++  FQLRAHMYQAR L A
Sbjct: 225  WLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFA 284

Query: 841  ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
            ADS+GLSDPFA+V F++  Q T+++++TL PTW+QML+F++L L+G+  EL + PP++V+
Sbjct: 285  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344

Query: 901  ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPR----LCYHPIFCGNLSGGDLLAVFEL 956
            E+YD D++GK +++G T A P+VK+AD+ Y PPR    L Y+ I+ GN + GDLLA FEL
Sbjct: 345  EIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFEL 404

Query: 957  LQVPPSGLQGLPPVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVD 1013
            LQ+ P+G   LPP+  P   D   I PVP  IRPVLSKYRVEVLFWG+R++K+V L  VD
Sbjct: 405  LQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVD 464

Query: 1014 RPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGR 1073
            RP+  IEC G+GV+S +I +YK NPNF+     FEV+LPENELLHPPL+I VVD RAFGR
Sbjct: 465  RPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGR 524

Query: 1074 STLVGTYTINYLKQFLCKLREPLAPI--TQVDGTQPGHDISDSLTATESSGAHSSSQDPP 1131
             TLVG++ ++ L++F+ +  +  AP   T V   +    + +  +++ S+G    + +P 
Sbjct: 525  YTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPE 584

Query: 1132 ADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPS 1191
                 V ++   T+V   A ++  + VDV +     + +    A+EP ++          
Sbjct: 585  -----VPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE---------- 629

Query: 1192 RRSTKRRKRTIADESAENVIDWWSKYYASLKKA---------------QKAKERNPKGKK 1236
                         E  E+++DWWSKY+AS+                  +K +  N +G K
Sbjct: 630  -------------EPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLK 676

Query: 1237 GNTEAKPDEVVVDIEDGPKKKKDKML----------KKKPKDDGIPNLAILQIYDGDLES 1286
            G+ + K        E   KKKK +            KKKPK D       L++Y  +LES
Sbjct: 677  GSMKGKEKARAAKEE---KKKKTQSSGSGQGSEAPEKKKPKIDE------LKVYPKELES 727

Query: 1287 EFNNFEDWVKTFELFRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSP--QDSSSEDS--GQ 1341
            EF+NFEDW+ TF L RGK+ +D+ G  + +R++G+FKGS C+YK P  +D S E      
Sbjct: 728  EFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDST 787

Query: 1342 LRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQL 1401
              + QGIP N P+ VL+RVY+V A +L PAD +GK+DPYI I+LGKT+I+D++ YI KQL
Sbjct: 788  YGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQL 847

Query: 1402 NPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQ 1461
            NPVFG+SF+I+A+FP ES+L++ +YD D++GTDDLIGETKIDLENRFYSKHRA CG+   
Sbjct: 848  NPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQT 907

Query: 1462 YEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDET 1520
            Y   GYN WRD  KP++ILT+LCKD K+DGP+F P G++++ N+VF+G +   E++  + 
Sbjct: 908  YSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQR 966

Query: 1521 VESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580
              + EH+AL  L  WEDIP  GCRLVPEH+ETRPL + DKPG+EQGRL++WVDMFP DMP
Sbjct: 967  KPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMP 1026

Query: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640
             PG P+DISPR+PK YELRV IWNT++V+LED++ FTG+KSSDI+V+GWLKG ++DKQ+T
Sbjct: 1027 APGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDT 1086

Query: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700
            DVHY+SLTGEGNFNWR+LFPF YL AE+++VI+K+E++FS ++ E K PA L LQ+WD +
Sbjct: 1087 DVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDAD 1146

Query: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF---- 1756
              S+DDFLG +E++LN FPR AK+AK C +       +   +SIF+QKRV+GWWP     
Sbjct: 1147 HFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARN 1206

Query: 1757 -SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYY 1815
             +   ELTGKVEAE HL+TAEEAEKNPVG AR EP+PL KPNRPDTSF WF++P K   Y
Sbjct: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARY 1266

Query: 1816 LIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
             +W  Y+  ++   +L++L++ L LF+Y++PG + ++I+
Sbjct: 1267 FLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 21/130 (16%)

Query: 263 MANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM--------- 313
           M      F  DS  L DPF  V F  Q   T V      P W + ++F  +         
Sbjct: 276 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHEL 335

Query: 314 --FPPLCRRVKIQVWDEGSMN--DVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYG 369
              PP+   + I+++D+ SM   D    T    L K++     D+ + P   P  +  Y 
Sbjct: 336 RDDPPI---IVIEIYDQDSMGKADFMGRTFAKPLVKMA-----DEAYCPPRFPPQLEYYQ 387

Query: 370 SPRNHSLMDD 379
             R ++   D
Sbjct: 388 IYRGNATAGD 397


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score = 1246 bits (3225), Expect = 0.0
 Identities = 631/1285 (49%), Positives = 878/1285 (68%), Gaps = 104/1285 (8%)

Query: 617  LIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCK 676
            +IK  +  PE +++ VL +       F+S A+K     ++T LD++RL  C +ELE M +
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 677  EAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIA 736
            +A+ +++ Q K+ +V + +   QNF++K+RFL DEPQH+IPD+FIWM+SNN+RVAYAR+ 
Sbjct: 61   QAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVP 119

Query: 737  SKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYLWLGSIKHASAIL 793
            SKDLL+S V  + GK C K+KT FLK PGKR    AGW+VQAKV++YLWLG  K     L
Sbjct: 120  SKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFL 179

Query: 794  DNLPVGYEAEMSSKGAGTN-HPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAK 852
              LP G++   +++G G +  PP +L+Y ++  FQLRAHMYQAR L AADS+GLSDPFA+
Sbjct: 180  CGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFAR 239

Query: 853  VTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPE 912
            V F++  Q T+++++TL PTW+QML+F++L L+G+  EL + PP++V+E+YD D++GK +
Sbjct: 240  VFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKAD 299

Query: 913  YLGATVAAPVVKLADQDYEPPR----LCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP 968
            ++G T A P+VK+AD+ Y PPR    L Y+ I+ GN + GDLLA FELLQ+ P+G   LP
Sbjct: 300  FMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP 359

Query: 969  PVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQG 1025
            P+  P   D   I PVP  IRPVLSKYRVEVLFWG+R++K+V L  VDRP+  IEC G+G
Sbjct: 360  PINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKG 419

Query: 1026 VKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYL 1085
            V+S +I +YK NPNF+     FEV+LPENELLHPPL+I VVD RAFGR TLVG++ ++ L
Sbjct: 420  VQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSL 479

Query: 1086 KQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTV 1145
            ++F+ +  +  AP                  +  ++G    + +P      V ++   T+
Sbjct: 480  RRFIYRPPDRSAP------------------SWNTTGEVVVTMEPE-----VPIKKLETM 516

Query: 1146 VPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADE 1205
            V   A ++  + VDV +     + +    A+EP ++                       E
Sbjct: 517  VKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE-----------------------E 553

Query: 1206 SAENVIDWWSKYYASLKKA---------------QKAKERNPKGKKGNTEAKPDEVVVDI 1250
              E+++DWWSKY+AS+                  +K +  N +G KG+ + K        
Sbjct: 554  PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE 613

Query: 1251 EDGPKKKKDKML----------KKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFEL 1300
            E   KKKK +            KKKPK D       L++Y  +LESEF+NFEDW+ TF L
Sbjct: 614  E---KKKKTQSSGSGQGSEAPEKKKPKIDE------LKVYPKELESEFDNFEDWLHTFNL 664

Query: 1301 FRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSP--QDSSSEDS--GQLRIQQGIPPNHPVT 1355
             RGK+ +D+ G  + +R++G+FKGS C+YK P  +D S E        + QGIP N P+ 
Sbjct: 665  LRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPIN 724

Query: 1356 VLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATF 1415
            VL+RVY+V A +L PAD +GK+DPYI I+LGKT+I+D++ YI KQLNPVFG+SF+I+A+F
Sbjct: 725  VLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASF 784

Query: 1416 PKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSK 1475
            P ES+L++ +YD D++GTDDLIGETKIDLENRFYSKHRA CG+   Y   GYN WRD  K
Sbjct: 785  PMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMK 844

Query: 1476 PTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHS 1534
            P++ILT+LCKD K+DGP+F P G++++ N+VF+G +   E++  +   + EH+AL  L  
Sbjct: 845  PSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQRKPTDEHVALLALRH 903

Query: 1535 WEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPK 1594
            WEDIP  GCRLVPEH+ETRPL + DKPG+EQGRL++WVDMFP DMP PG P+DISPR+PK
Sbjct: 904  WEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPK 963

Query: 1595 GYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFN 1654
             YELRV IWNT++V+LED++ FTG+KSSDI+V+GWLKG ++DKQ+TDVHY+SLTGEGNFN
Sbjct: 964  KYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFN 1023

Query: 1655 WRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMN 1714
            WR+LFPF YL AE+++VI+K+E++FS ++ E K PA L LQ+WD +  S+DDFLG +E++
Sbjct: 1024 WRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELD 1083

Query: 1715 LNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF-----SKSKELTGKVEAE 1769
            LN FPR AK+AK C +       +   +SIF+QKRV+GWWP      +   ELTGKVEAE
Sbjct: 1084 LNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAE 1143

Query: 1770 FHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAF 1829
             HL+TAEEAEKNPVG AR EP+PL KPNRPDTSF WF++P K   Y +W  Y+  ++   
Sbjct: 1144 LHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLL 1203

Query: 1830 ILIILIIFLVLFIYTLPGAISRRIV 1854
            +L++L++ L LF+Y++PG + ++I+
Sbjct: 1204 LLLLLLLLLALFLYSVPGYLVKKIL 1228



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 21/130 (16%)

Query: 263 MANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM--------- 313
           M      F  DS  L DPF  V F  Q   T V      P W + ++F  +         
Sbjct: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHEL 278

Query: 314 --FPPLCRRVKIQVWDEGSMN--DVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYG 369
              PP+   + I+++D+ SM   D    T    L K++     D+ + P   P  +  Y 
Sbjct: 279 RDDPPI---IVIEIYDQDSMGKADFMGRTFAKPLVKMA-----DEAYCPPRFPPQLEYYQ 330

Query: 370 SPRNHSLMDD 379
             R ++   D
Sbjct: 331 IYRGNATAGD 340


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 632/1285 (49%), Positives = 877/1285 (68%), Gaps = 104/1285 (8%)

Query: 617  LIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCK 676
            +IK  +  PE +++ VL +       F+S A+K     ++T LD++RL  C +ELE M +
Sbjct: 1    MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQ 60

Query: 677  EAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIA 736
            +A+ +++ Q K+ +V + +   QNF++K+RFL DEPQH+IPD+FIWM+SNN+RVAYAR+ 
Sbjct: 61   QAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVP 119

Query: 737  SKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYLWLGSIKHASAIL 793
            SKDLL+S V  + GK C K+KT FLK PGKR    AGW+VQAKV++YLWLG  K     L
Sbjct: 120  SKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFL 179

Query: 794  DNLPVGYEAEMSSKGAGTN-HPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAK 852
              LP G++   +++G G +  PP +L+Y ++  FQLRAHMYQAR L AADS+GLSDPFA+
Sbjct: 180  CGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFAR 239

Query: 853  VTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPE 912
            V F++  Q T+++++TL PTW+QML+F++L L+G+  EL + PP++V+E+YD D++GK +
Sbjct: 240  VFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKAD 299

Query: 913  YLGATVAAPVVKLADQDYEPPR----LCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP 968
            ++G T A P+VK+AD+ Y PPR    L Y+ I+ GN + GDLLA FELLQ+ P+G   LP
Sbjct: 300  FMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLP 359

Query: 969  PVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQG 1025
            P+  P   D   I PVP  IRPVLSKYRVEVLFWG+R++K+V L  VDRP+  IEC G+G
Sbjct: 360  PINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKG 419

Query: 1026 VKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYL 1085
            V+S +I +YK NPNF+     FEV+LPENELLHPPL+I VVD RAFGR TLVG++ ++ L
Sbjct: 420  VQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSL 479

Query: 1086 KQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTV 1145
            ++F+ +  +  AP                  +  ++G    + +P      V ++   T+
Sbjct: 480  RRFIYRPPDRSAP------------------SWNTTGEVVVTMEPE-----VPIKKLETM 516

Query: 1146 VPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADE 1205
            V   A ++  + VDV +     + +    A+EP ++                       E
Sbjct: 517  VKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE-----------------------E 553

Query: 1206 SAENVIDWWSKYYASLKKA---------------QKAKERNPKGKKGNTEAKPDEVVVDI 1250
              E+++DWWSKY+AS+                  +K +  N +G KG+ + K        
Sbjct: 554  PDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKE 613

Query: 1251 EDGPKKKKDKML----------KKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFEL 1300
            E   KKKK +            KKKPK D       L++Y  +LESEF+NFEDW+ TF L
Sbjct: 614  E---KKKKTQSSGSGQGSEAPEKKKPKIDE------LKVYPKELESEFDNFEDWLHTFNL 664

Query: 1301 FRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSP--QDSSSEDS--GQLRIQQGIPPNHPVT 1355
             RGK+ +D+ G  + +R++G+FKGS C+YK P  +D S E        + QGIP N P+ 
Sbjct: 665  LRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPIN 724

Query: 1356 VLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATF 1415
            VL+RVY+V A +L PAD +GK+DPYI I+LGKT+I+D++ YI KQLNPVFG+SF+I+A+F
Sbjct: 725  VLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASF 784

Query: 1416 PKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSK 1475
            P ES+L++ +YD D++GTDDLIGETKIDLENRFYSKHRA CG+   Y   GYN WRD  K
Sbjct: 785  PMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMK 844

Query: 1476 PTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHS 1534
            P++ILT+LCKD K+DGP+F P G++++ N+VF+G +   E++  +   + EH+AL  L  
Sbjct: 845  PSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQRKPTDEHVALLALRH 903

Query: 1535 WEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPK 1594
            WEDIP  GCRLVPEH+ETRPL + DKPG+EQGRL++WVDMFP DMP PG P+DISPR+PK
Sbjct: 904  WEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPK 963

Query: 1595 GYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFN 1654
             YELRV IWNT++V+LED++ FTG+KSSDI+V+GWLKG ++DKQ+TDVHY+SLTGEGNFN
Sbjct: 964  KYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFN 1023

Query: 1655 WRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMN 1714
            WR+LFPF YL AE+++VI+K+E++FS ++ E K PA L LQ+WD +  S+DDFLG +E++
Sbjct: 1024 WRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELD 1083

Query: 1715 LNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPF-----SKSKELTGKVEAE 1769
            LN FPR AK+AK C +       +   +SIF+QKRV+GWWP      +   ELTGKVEAE
Sbjct: 1084 LNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAE 1143

Query: 1770 FHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAF 1829
             HL+TAEEAEKNPVG AR EP+PL KPNRPDT+F WF++P K + YLI   YK  II   
Sbjct: 1144 LHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIV 1203

Query: 1830 ILIILIIFLVLFIYTLPGAISRRIV 1854
            + ++ ++ L LF+Y+LPG + ++++
Sbjct: 1204 LALLGLLMLGLFLYSLPGYMVKKLL 1228



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 32/130 (24%), Positives = 49/130 (37%), Gaps = 21/130 (16%)

Query: 263 MANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM--------- 313
           M      F  DS  L DPF  V F  Q   T V      P W + ++F  +         
Sbjct: 219 MYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHEL 278

Query: 314 --FPPLCRRVKIQVWDEGSMN--DVALATHFIDLKKISNEQDGDKGFLPTFGPAWINLYG 369
              PP+   + I+++D+ SM   D    T    L K++     D+ + P   P  +  Y 
Sbjct: 279 RDDPPI---IVIEIYDQDSMGKADFMGRTFAKPLVKMA-----DEAYCPPRFPPQLEYYQ 330

Query: 370 SPRNHSLMDD 379
             R ++   D
Sbjct: 331 IYRGNATAGD 340


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1148 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1207

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1208 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1267

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1268 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1321

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1322 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1381

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1382 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1441

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1442 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1479

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1480 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1510

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1511 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1535

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1536 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1584

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1585 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1642

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1643 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1702

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1703 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1762

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1763 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1814

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1815 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1873

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1874 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1933

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1934 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1993

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1994 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2053

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2054 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2113

Query: 1853 IV 1854
            +V
Sbjct: 2114 LV 2115



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 248 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 306

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 307 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 366

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 367 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 424

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 425 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 484

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 485 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 543

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 544 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 595

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 596 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 617

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 618 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 644

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 645 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 702

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 703 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 759

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 760 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 813

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 814 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 873

Query: 781 LWLG 784
           LW G
Sbjct: 874 LWFG 877



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1186 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1226



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/44 (34%), Positives = 26/44 (59%)

Query: 832 MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+
Sbjct: 6   LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE 49



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 442 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 496

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 497 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 529



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1117 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1176

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1177 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1236

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1237 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1290

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1291 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1350

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1351 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1410

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1411 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1448

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1449 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1479

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1480 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1504

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1505 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1553

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1554 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1611

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1612 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1671

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1672 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1731

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1732 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1783

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1784 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1842

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1843 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1902

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1903 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1962

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1963 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2022

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2023 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2082

Query: 1853 IV 1854
            +V
Sbjct: 2083 LV 2084



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 217 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 275

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 276 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 335

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 336 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 393

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 394 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 453

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 454 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 512

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 513 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 564

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 565 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 586

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 587 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 613

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 614 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 671

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 672 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 728

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 729 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 782

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 783 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 842

Query: 781 LWLG 784
           LW G
Sbjct: 843 LWFG 846



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1155 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1195



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 51/209 (24%), Positives = 80/209 (38%), Gaps = 47/209 (22%)

Query: 832  MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVK-- 889
            + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+           D+K  
Sbjct: 6    LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE-------GFEWDLKGI 58

Query: 890  ELAESPPLVVVELYDSDAVGKPEYLG-------ATVAAPVVK------LADQDYEPPRLC 936
             L +   L VV + D + +G+  +LG         +A P +       L D   +P    
Sbjct: 59   PLDQGSELHVV-VKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQP---- 113

Query: 937  YHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEV 996
                     +G  L     +LQV  + L G  P+ PP      P P    P L    V  
Sbjct: 114  ---------TGASL-----VLQVSYTPLPGAVPLFPP------PTPLEPSPTLPDLDVVA 153

Query: 997  LFWGVREMKKVQLLSVDRPQALIECGGQG 1025
               G  + +   L   +    L + GG G
Sbjct: 154  DTGGEEDTEDQGLTGDEAEPFLDQSGGPG 182



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 411 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 465

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 466 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 498



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1131 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1190

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1191 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1250

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1251 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1304

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1305 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1364

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1365 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1424

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1425 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1462

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1463 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1493

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1494 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1518

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1519 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1567

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1568 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1625

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1626 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1685

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1686 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1745

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1746 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1797

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1798 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1856

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1857 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1916

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1917 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1976

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1977 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2036

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2037 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2096

Query: 1853 IV 1854
            +V
Sbjct: 2097 LV 2098



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 217 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 275

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 276 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 335

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 336 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 393

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 394 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 453

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 454 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 512

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 513 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 571

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 572 -------KVEDLPADD------------------------------ILRVEKY------- 587

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 588 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 626

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 627 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 671

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 672 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 731

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 732 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 782

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 783 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 842

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 843 KVPGARMPVQIRVKLWFG 860



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1169 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1209



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 51/209 (24%), Positives = 80/209 (38%), Gaps = 47/209 (22%)

Query: 832  MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVK-- 889
            + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+           D+K  
Sbjct: 6    LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE-------GFEWDLKGI 58

Query: 890  ELAESPPLVVVELYDSDAVGKPEYLG-------ATVAAPVVK------LADQDYEPPRLC 936
             L +   L VV + D + +G+  +LG         +A P +       L D   +P    
Sbjct: 59   PLDQGSELHVV-VKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQP---- 113

Query: 937  YHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEV 996
                     +G  L     +LQV  + L G  P+ PP      P P    P L    V  
Sbjct: 114  ---------TGASL-----VLQVSYTPLPGAVPLFPP------PTPLEPSPTLPDLDVVA 153

Query: 997  LFWGVREMKKVQLLSVDRPQALIECGGQG 1025
               G  + +   L   +    L + GG G
Sbjct: 154  DTGGEEDTEDQGLTGDEAEPFLDQSGGPG 182



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 411 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1147 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1206

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1207 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1266

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1267 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1320

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1321 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1380

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1381 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1440

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1441 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1478

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1479 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1509

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1510 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1534

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1535 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1583

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1584 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1641

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1642 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1701

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1702 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1761

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1762 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1813

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1814 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1872

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1873 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1932

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1933 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1992

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1993 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2052

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2053 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2112

Query: 1853 IV 1854
            +V
Sbjct: 2113 LV 2114



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 247 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 305

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 306 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 365

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 366 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 423

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 424 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 483

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 484 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 542

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 543 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 594

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 595 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 616

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 617 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 643

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 644 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 701

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 702 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 758

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 759 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 812

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 813 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 872

Query: 781 LWLG 784
           LW G
Sbjct: 873 LWFG 876



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1185 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1225



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 441 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 495

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 496 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 528



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1130 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1189

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1190 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1249

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1250 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1303

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1304 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1363

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1364 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1423

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1424 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1461

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1462 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1492

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1493 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1517

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1518 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1566

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1567 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1624

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1625 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1684

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1685 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1744

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1745 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1796

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1797 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1855

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1856 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1915

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1916 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1975

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1976 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2035

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2036 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2095

Query: 1853 IV 1854
            +V
Sbjct: 2096 LV 2097



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 216 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 274

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 275 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 334

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 335 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 392

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 393 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 452

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 453 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 511

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 512 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 570

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 571 -------KVEDLPADD------------------------------ILRVEKY------- 586

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 587 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 625

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 626 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 670

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 671 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 730

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 731 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 781

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 782 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 841

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 842 KVPGARMPVQIRVKLWFG 859



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1168 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1208



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 410 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score =  720 bits (1858), Expect = 0.0
 Identities = 406/1082 (37%), Positives = 585/1082 (54%), Gaps = 145/1082 (13%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1116 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1175

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1176 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1235

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1236 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1289

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1290 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1349

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1350 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1409

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC      +P  Q                    G    S   P + + +D++   
Sbjct: 1410 SLESFLCDPYSAESPSPQ-------------------GGPDDVSLLSPGEDVLIDID--- 1447

Query: 1144 TVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIA 1203
                     +P I + + D    L P +T      P +                      
Sbjct: 1448 -------DKEPLIPIQLADGLSSLAPTNTASPPSSPHE---------------------- 1478

Query: 1204 DESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLK 1263
                E  IDWWSK++AS+                               G ++K    L+
Sbjct: 1479 ----EEFIDWWSKFFASI-------------------------------GEREKCGSYLE 1503

Query: 1264 KKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKF 1321
            K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VIG+F
Sbjct: 1504 K--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVIGEF 1552

Query: 1322 KGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYI 1381
            KG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK DPYI
Sbjct: 1553 KGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYI 1610

Query: 1382 VIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETK 1441
             I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IGET 
Sbjct: 1611 KISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETV 1670

Query: 1442 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQI 1501
            +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   ++  
Sbjct: 1671 VDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDRVMF 1730

Query: 1502 GNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK 1560
             ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY   +
Sbjct: 1731 QDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYSPLQ 1782

Query: 1561 PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK 1620
            P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ TG+K
Sbjct: 1783 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-TGEK 1841

Query: 1621 SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS 1680
             SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++  + 
Sbjct: 1842 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1901

Query: 1681 LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA-SEE 1739
            L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A   E
Sbjct: 1902 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAFHPE 1961

Query: 1740 TKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE---P 1792
              +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP     
Sbjct: 1962 WFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPK 2021

Query: 1793 LAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRR 1852
            L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   + +
Sbjct: 2022 LEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMK 2081

Query: 1853 IV 1854
            +V
Sbjct: 2082 LV 2083



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 216 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 274

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 275 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 334

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 335 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 392

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 393 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 452

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 453 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 511

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 512 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 563

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 564 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 585

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 586 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 612

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 613 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 670

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 671 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 727

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 728 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 781

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 782 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 841

Query: 781 LWLG 784
           LW G
Sbjct: 842 LWFG 845



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1154 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1194



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 410 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 464

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 465 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 497



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1131 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1190

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1191 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1250

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1251 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1304

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1305 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1364

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1365 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1424

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1425 SLESFLC--------------------------------------DP-----YSAESPSP 1441

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1442 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1473

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1474 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1494

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1495 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1543

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1544 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1601

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1602 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1661

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1662 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1721

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1722 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1773

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1774 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1832

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1833 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1892

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1893 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1952

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1953 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2012

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2013 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2072

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2073 AMKLV 2077



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 217 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 275

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 276 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 335

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 336 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 393

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 394 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 453

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 454 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 512

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 513 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 571

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 572 -------KVEDLPADD------------------------------ILRVEKY------- 587

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 588 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 626

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 627 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 671

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 672 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 731

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 732 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 782

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 783 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 842

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 843 KVPGARMPVQIRVKLWFG 860



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1169 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1209



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 51/209 (24%), Positives = 80/209 (38%), Gaps = 47/209 (22%)

Query: 832  MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVK-- 889
            + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+           D+K  
Sbjct: 6    LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE-------GFEWDLKGI 58

Query: 890  ELAESPPLVVVELYDSDAVGKPEYLG-------ATVAAPVVK------LADQDYEPPRLC 936
             L +   L VV + D + +G+  +LG         +A P +       L D   +P    
Sbjct: 59   PLDQGSELHVV-VKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQP---- 113

Query: 937  YHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEV 996
                     +G  L     +LQV  + L G  P+ PP      P P    P L    V  
Sbjct: 114  ---------TGASL-----VLQVSYTPLPGAVPLFPP------PTPLEPSPTLPDLDVVA 153

Query: 997  LFWGVREMKKVQLLSVDRPQALIECGGQG 1025
               G  + +   L   +    L + GG G
Sbjct: 154  DTGGEEDTEDQGLTGDEAEPFLDQSGGPG 182



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 411 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 445



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1130 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1189

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1190 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1249

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1250 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1303

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1304 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1363

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1364 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1423

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1424 SLESFLC--------------------------------------DP-----YSAESPSP 1440

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1441 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1472

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1473 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1493

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1494 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1542

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1543 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1600

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1601 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1660

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1661 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1720

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1721 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1772

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1773 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1831

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1832 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1891

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1892 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1951

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1952 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2011

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2012 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2071

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2072 AMKLV 2076



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 216 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 274

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 275 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 334

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 335 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 392

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 393 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 452

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 453 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 511

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 512 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 570

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 571 -------KVEDLPADD------------------------------ILRVEKY------- 586

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 587 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 625

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 626 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 670

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 671 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 730

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 731 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 781

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 782 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 841

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 842 KVPGARMPVQIRVKLWFG 859



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1168 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1208



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 410 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 444



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1117 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1176

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1177 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1236

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1237 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1290

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1291 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1350

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1351 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1410

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1411 SLESFLC--------------------------------------DP-----YSAESPSP 1427

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1428 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1459

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1460 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1480

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1481 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1529

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1530 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1587

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1588 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1647

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1648 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1707

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1708 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1759

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1760 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1818

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1819 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1878

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1879 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1938

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1939 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 1998

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 1999 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2058

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2059 AMKLV 2063



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 217 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 275

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 276 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 335

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 336 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 393

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 394 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 453

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 454 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 512

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 513 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 564

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 565 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 586

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 587 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 613

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 614 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 671

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 672 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 728

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 729 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 782

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 783 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 842

Query: 781 LWLG 784
           LW G
Sbjct: 843 LWFG 846



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1155 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1195



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 51/209 (24%), Positives = 80/209 (38%), Gaps = 47/209 (22%)

Query: 832  MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVK-- 889
            + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+           D+K  
Sbjct: 6    LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE-------GFEWDLKGI 58

Query: 890  ELAESPPLVVVELYDSDAVGKPEYLG-------ATVAAPVVK------LADQDYEPPRLC 936
             L +   L VV + D + +G+  +LG         +A P +       L D   +P    
Sbjct: 59   PLDQGSELHVV-VKDHETMGRNRFLGEAKVPLREVLATPSLSASFNAPLLDTKKQP---- 113

Query: 937  YHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEV 996
                     +G  L     +LQV  + L G  P+ PP      P P    P L    V  
Sbjct: 114  ---------TGASL-----VLQVSYTPLPGAVPLFPP------PTPLEPSPTLPDLDVVA 153

Query: 997  LFWGVREMKKVQLLSVDRPQALIECGGQG 1025
               G  + +   L   +    L + GG G
Sbjct: 154  DTGGEEDTEDQGLTGDEAEPFLDQSGGPG 182



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 411 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 465

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 466 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 498



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1148 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1207

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1208 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1267

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1268 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1321

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1322 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1381

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1382 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1441

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1442 SLESFLC--------------------------------------DP-----YSAESPSP 1458

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1459 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1490

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1491 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1511

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1512 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1560

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1561 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1618

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1619 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1678

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1679 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1738

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1739 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1790

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1791 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1849

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1850 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1909

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1910 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1969

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1970 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2029

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2030 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2089

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2090 AMKLV 2094



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 248 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 306

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 307 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 366

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 367 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 424

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 425 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 484

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 485 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 543

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 544 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 595

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 596 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 617

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 618 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 644

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 645 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 702

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 703 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 759

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 760 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 813

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 814 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 873

Query: 781 LWLG 784
           LW G
Sbjct: 874 LWFG 877



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1186 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1226



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/44 (34%), Positives = 26/44 (59%)

Query: 832 MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+
Sbjct: 6   LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE 49



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 442 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 496

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 497 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 529



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1162 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1221

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1222 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1281

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1282 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1335

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1336 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1395

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1396 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1455

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1456 SLESFLC--------------------------------------DP-----YSAESPSP 1472

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1473 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1504

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1505 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1525

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1526 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1574

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1575 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1632

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1633 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1692

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1693 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1752

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1753 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1804

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1805 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1863

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1864 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1923

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1924 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1983

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1984 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2043

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2044 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2103

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2104 AMKLV 2108



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 248 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 306

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 307 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 366

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 367 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 424

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 425 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 484

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 485 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 543

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 544 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 602

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 603 -------KVEDLPADD------------------------------ILRVEKY------- 618

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 619 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 657

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 658 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 702

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 703 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 762

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 763 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 813

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 814 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 873

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 874 KVPGARMPVQIRVKLWFG 891



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 1362 IVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT---FPKE 1418
            +V A NL  A  D +SDP  V  L    +K R K I   +NPV+   FE         + 
Sbjct: 6    LVRASNLPSAKKDRRSDP--VASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQG 63

Query: 1419 SLLSILIYDHDMIGTDDLIGETKIDL 1444
            S L +++ DH+ +G +  +GE K+ L
Sbjct: 64   SELHVVVKDHETMGRNRFLGEAKVPL 89



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1200 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1240



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 15/44 (34%), Positives = 26/44 (59%)

Query: 832 MYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           + +A  L +A  +  SDP A +TF    + TK+I  +++P WN+
Sbjct: 6   LVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNE 49



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 442 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 476



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 13/28 (46%), Positives = 17/28 (60%)

Query: 279 DPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           DP   ++F G   RT V KN  +PVW+E
Sbjct: 22  DPVASLTFRGVKKRTKVIKNSVNPVWNE 49


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1147 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1206

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1207 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1266

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1267 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1320

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1321 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1380

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1381 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1440

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1441 SLESFLC--------------------------------------DP-----YSAESPSP 1457

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1458 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1489

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1490 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1510

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1511 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1559

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1560 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1617

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1618 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1677

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1678 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1737

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1738 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1789

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1790 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1848

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1849 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1908

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1909 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1968

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1969 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2028

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2029 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2088

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2089 AMKLV 2093



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 247 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 305

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 306 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 365

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 366 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 423

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 424 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 483

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 484 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 542

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 543 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 594

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 595 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 616

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 617 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 643

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 644 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 701

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 702 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 758

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 759 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 812

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 813 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 872

Query: 781 LWLG 784
           LW G
Sbjct: 873 LWFG 876



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1185 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1225



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 441 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 495

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 496 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 528



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1161 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1220

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1221 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1280

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1281 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1334

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1335 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1394

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1395 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1454

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1455 SLESFLC--------------------------------------DP-----YSAESPSP 1471

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1472 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1503

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1504 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1524

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1525 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1573

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1574 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1631

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1632 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1691

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1692 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1751

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1752 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1803

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1804 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1862

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1863 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1922

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1923 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1982

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1983 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2042

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 2043 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2102

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2103 AMKLV 2107



 Score =  343 bits (879), Expect = 1e-93
 Identities = 235/738 (31%), Positives = 373/738 (50%), Gaps = 126/738 (17%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 247 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 305

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 306 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 365

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 366 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 423

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 424 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 483

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKIS-------------------NEQDGD 353
           P +C +++I++  WD  + ND+ +AT ++ + KIS                   ++ D  
Sbjct: 484 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEEEPAGAVKPSKASDLDDY 542

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GFLPTFGP +INLYGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q 
Sbjct: 543 LGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ- 601

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                  K   LP+ D                               + VE +       
Sbjct: 602 -------KVEDLPADD------------------------------ILRVEKY------- 617

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
             +  ++ LF AF+ ATM+     D  I FEVSIGN+GN  D                  
Sbjct: 618 -LRRRKYSLFAAFYSATMLQDV--DDAIQFEVSIGNYGNKFD------------------ 656

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                           +P+ASTT   + +      +Y YLP+   KP V   S W D + 
Sbjct: 657 -------------MTCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISH 701

Query: 593 RLHWSNMLEKMADFLEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           R+   N L  +AD LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + 
Sbjct: 702 RIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHET 761

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRF 707
           P   + T LD+    L    L  + + A  +      KL   E+   + +A++++ ++R 
Sbjct: 762 P---SATHLDQYLYQLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRA 812

Query: 708 LVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGK 766
           L +EPQ+++PD+ IWML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P +
Sbjct: 813 LAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPME 872

Query: 767 RPAGWSVQAKVDVYLWLG 784
           +  G  +  ++ V LW G
Sbjct: 873 KVPGARMPVQIRVKLWFG 890



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1199 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1239



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQ 875
           ++   L DPF +V+F      +KI+ +T +P WNQ
Sbjct: 441 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ 475



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score =  709 bits (1830), Expect = 0.0
 Identities = 405/1085 (37%), Positives = 580/1085 (53%), Gaps = 172/1085 (15%)

Query: 804  MSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTK 863
            +S+   G N P  + ++   + + LR +MYQAR L A D +  SDP+A V+FL   Q T 
Sbjct: 1116 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1175

Query: 864  IISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVV 923
            ++  TL+PTW+Q L+F ++ + G+   +AE PP +VVELYD D  G  E++G  +  P +
Sbjct: 1176 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQPSL 1235

Query: 924  KLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLP--------------- 968
            +        PRL + P+  G+   G+LLA FEL+Q     +  +P               
Sbjct: 1236 E------RMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1289

Query: 969  ----PVEPPDI-TQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGG 1023
                P  PP     IY VP NI+P L +  +E+L WG+R MK  QL ++  P  ++ECGG
Sbjct: 1290 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1349

Query: 1024 QGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTIN 1083
            Q V+SCVI++ + NPNF I     EV LP  EL  PP+++ V+D R FGR  +VG  TI 
Sbjct: 1350 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1409

Query: 1084 YLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPP 1143
             L+ FLC                                      DP     Y    P P
Sbjct: 1410 SLESFLC--------------------------------------DP-----YSAESPSP 1426

Query: 1144 TVVPDSAQAQPA---ILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR 1200
               PD          +L+D+ D  P++     P+ +E                       
Sbjct: 1427 QGGPDDVSLLSPGEDVLIDIDDKEPLI-----PIQEE----------------------- 1458

Query: 1201 TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK 1260
                      IDWWSK++AS+                               G ++K   
Sbjct: 1459 --------EFIDWWSKFFASI-------------------------------GEREKCGS 1479

Query: 1261 MLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDRVI 1318
             L+K        +   L++YD  LE+   F    D+  TF+L+RGK+ E+    +   VI
Sbjct: 1480 YLEK--------DFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET---EDPSVI 1528

Query: 1319 GKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSD 1378
            G+FKG F IY  P+D +     +   Q  +    P   L+R+YIV AF L P DP+GK D
Sbjct: 1529 GEFKGLFKIYPLPEDPAIPMPPRQFHQ--LAAQGPQECLVRIYIVRAFGLQPKDPNGKCD 1586

Query: 1379 PYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
            PYI I +GK  + D+D YIP  L PVFG+ FE+  T P E  L I +YD+D++  D+ IG
Sbjct: 1587 PYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIG 1646

Query: 1439 ETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGK 1498
            ET +DLENR  SK  A CGL   Y + G N WRD  +P+++L   C+ +++  P +   +
Sbjct: 1647 ETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTDR 1706

Query: 1499 IQIGNQVFSGKTIFTEEDTDETVESYEH-LALKVLHSWEDIPEVGCRLVPEHIETRPLYH 1557
            +   ++ +S + I      +  +   E  LAL VL            LVPEH+E+RPLY 
Sbjct: 1707 VMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG--------LVPEHVESRPLYS 1758

Query: 1558 KDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFT 1617
              +P +EQG+LQMWVD+FPK + +PGPP +I+PRR + + LR  IWNT DVIL+D ++ T
Sbjct: 1759 PLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL-T 1817

Query: 1618 GQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKREN 1677
            G+K SDIYVKGW+ G E+ KQ+TDVHY SL GEGNFNWRF+FPF YLPAE+   I K++ 
Sbjct: 1818 GEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDA 1877

Query: 1678 IFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENA- 1736
             + L+K E K PA +V Q+WD ++ S DDFLG+L+++LN  P+ AK+AK C L + ++A 
Sbjct: 1878 FWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDDAF 1937

Query: 1737 SEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPE- 1791
              E  +S+F+QK V+GWWP      + K L GK+E    +V   E E+ P G+ R EP  
Sbjct: 1938 HPEWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 1997

Query: 1792 --PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAI 1849
               L  P RPDTSF WF SP+K + +++W+ ++  II+  IL IL++FL +FIY  P   
Sbjct: 1998 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2057

Query: 1850 SRRIV 1854
            + ++V
Sbjct: 2058 AMKLV 2062



 Score =  348 bits (893), Expect = 3e-95
 Identities = 236/724 (32%), Positives = 372/724 (51%), Gaps = 112/724 (15%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++QI + + E RQL G NI PVV +    + K++ + +G NSP +NE   F+     
Sbjct: 216 KPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKG-NSPLFNETLFFNLFDSP 274

Query: 139 VHLFDKIIKISVFHHKLIGS-VLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTK 197
             LFD+ I I+V   + + +  L+G F++D+GT+Y +P H +  KW LL+DP D   G +
Sbjct: 275 GELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGAR 334

Query: 198 GYLKCDISVMGKGDVLKTSPK-TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEGLP 256
           GYLK  + V+G GD      K  S+ +E IE NLL P G  L    A F +++++AE LP
Sbjct: 335 GYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALR--GAHFCLKVFRAEDLP 392

Query: 257 KMNSSIMANVTK--AFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMF 314
           +M+ ++M NV +   F  + K+LVDPFVEVSFAG+M  + + +  A+P W++ +    MF
Sbjct: 393 QMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITLPAMF 452

Query: 315 PPLCRRVKIQV--WDEGSMNDVALATHFIDLKKISN-----EQDGDKGFLPTFGPAWINL 367
           P +C +++I++  WD  + ND+ +AT ++ + KIS      E D   GFLPTFGP +INL
Sbjct: 453 PSMCEKMRIRIIDWDRLTHNDI-VATTYLSMSKISAPGGEIEVDDYLGFLPTFGPCYINL 511

Query: 368 YGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLPS 426
           YGSPR  +   D Y E+N G GEGV++RGR+L+ +  +++    Q        K   LP+
Sbjct: 512 YGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVEHSEQ--------KVEDLPA 563

Query: 427 KDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAFF 486
            D                               + VE +         +  ++ LF AF+
Sbjct: 564 DD------------------------------ILRVEKY--------LRRRKYSLFAAFY 585

Query: 487 EATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAHD 546
            ATM+     D  I FEVSIGN+GN  D                                
Sbjct: 586 SATMLQDV--DDAIQFEVSIGNYGNKFD-------------------------------M 612

Query: 547 VPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMADF 606
             +P+ASTT   + +      +Y YLP+   KP V   S W D + R+   N L  +AD 
Sbjct: 613 TCLPLASTTQYSRAVF--DGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 670

Query: 607 LEESIEEVRELIK--ISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRL 664
           LE  +E+V   +K   S E  +  +  +  + I+  S  + +  + P   + T LD+   
Sbjct: 671 LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETP---SATHLDQYLY 727

Query: 665 TLCWQELEAMCKEAKGIIQQQKKKLSVDEM---IHEAQNFVEKIRFLVDEPQHTIPDVFI 721
            L    L  + + A  +      KL   E+   + +A++++ ++R L +EPQ+++PD+ I
Sbjct: 728 QLRTHHLSQITEAALAL------KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVI 781

Query: 722 WMLSNNRRVAYARIASKDLLYS-PVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY 780
           WML  ++RVAY R+ +  +L+S   A   GK+CGK++T FLK P ++  G  +  ++ V 
Sbjct: 782 WMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVK 841

Query: 781 LWLG 784
           LW G
Sbjct: 842 LWFG 845



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 6/91 (6%)

Query: 1357 LIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQAT-- 1414
            ++RV+I+ A N+   D D  SD Y         +K R K I   +NPV+   FE      
Sbjct: 1    MLRVFILYAENVHTPDTD-ISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGI 57

Query: 1415 -FPKESLLSILIYDHDMIGTDDLIGETKIDL 1444
               + S L +++ DH+ +G +  +GE K+ L
Sbjct: 58   PLDQGSELHVVVKDHETMGRNRFLGEAKVPL 88



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 16/41 (39%), Positives = 22/41 (53%)

Query: 273  DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
            D     DP+  VSF  Q  +T V KN  +P W + +IF E+
Sbjct: 1154 DKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEI 1194



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 8/93 (8%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           ++   L DPF +V+F      +KI+ +T +P WNQ     ++ L      + E   + ++
Sbjct: 410 SNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQ-----NITLPAMFPSMCEKMRIRII 464

Query: 901 E---LYDSDAVGKPEYLGATVAAPVVKLADQDY 930
           +   L  +D V       + ++AP  ++   DY
Sbjct: 465 DWDRLTHNDIVATTYLSMSKISAPGGEIEVDDY 497



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 14/31 (45%), Positives = 18/31 (58%)

Query: 276 DLVDPFVEVSFAGQMGRTTVQKNCADPVWHE 306
           D+ D +    FAG   RT V KN  +PVW+E
Sbjct: 18  DISDAYCSAVFAGVKKRTKVIKNSVNPVWNE 48


>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score =  689 bits (1779), Expect = 0.0
 Identities = 393/1066 (36%), Positives = 585/1066 (54%), Gaps = 152/1066 (14%)

Query: 810  GTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTL 869
            G N P  +  +   +++ LR ++YQAR L+A D +  SDP+A + FL   +TT+II  TL
Sbjct: 1110 GANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTL 1169

Query: 870  SPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQD 929
            +PTW+Q ++F+++ ++G+ + + ++PP V++EL+D+D VGK E+LG ++ +PVVKL  + 
Sbjct: 1170 NPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM 1229

Query: 930  YEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVL 989
               P+L +HP+  G+ + GD+L   EL+     G   LP + P     +Y VP  IRPV+
Sbjct: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDG-SNLPILPPQRAPNLYMVPQGIRPVV 1288

Query: 990  SKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEV 1049
                +E+L WG+R MK  Q+ S+  P  ++ECGG+ V+S VI++ K  PNF       +V
Sbjct: 1289 QLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKV 1348

Query: 1050 ELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGH 1109
             LP+ EL  PPL I V+D R FGR  +VG  TI  L +F C            D      
Sbjct: 1349 FLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRC------------DPYAGKE 1396

Query: 1110 DISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEP 1169
            DI   L A+  S        PP   I +++E                     D+ P+L  
Sbjct: 1397 DIVPQLKASLLSA-------PPCRDIVIEME---------------------DTKPLLAS 1428

Query: 1170 EHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKE 1229
            + T                                E  E ++DWWSK+YAS  + +K  +
Sbjct: 1429 KLT--------------------------------EKEEEIVDWWSKFYASSGEHEKCGQ 1456

Query: 1230 RNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGIPNLAILQIYDGDLES--E 1287
               KG                                        + L+IY+ +LE+  E
Sbjct: 1457 YIQKG---------------------------------------YSKLKIYNCELENVAE 1477

Query: 1288 FNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLRIQQG 1347
            F    D+  TF+L+RGKS E++       V+G+FKGSF IY  P D S       R  + 
Sbjct: 1478 FEGLTDFSDTFKLYRGKSDENED----PSVVGEFKGSFRIYPLPDDPSVP--APPRQFRE 1531

Query: 1348 IPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGR 1407
            +P + P    +R+YIV    L P D +G  DPYI I LGK  I+DRD YIP  LNPVFGR
Sbjct: 1532 LPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGR 1591

Query: 1408 SFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGY 1467
             +E+    P+E  L I +YD+D    D+ +GET IDLENRF S+  + CG+  +Y + G 
Sbjct: 1592 MYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGV 1651

Query: 1468 NAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESY- 1524
            N WRD  +PT++L  + +      P       +I+ G + +S      E + ++ +  + 
Sbjct: 1652 NTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS----LDEFEANKILHQHL 1707

Query: 1525 ----EHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580
                E LAL +L +          LVPEH+ETR L+   +P + QG+LQMWVD+FPK + 
Sbjct: 1708 GAPEERLALHILRTQG--------LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLG 1759

Query: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640
             PGPP +I+PR+ K Y LRV IWNT+DVIL++++I TG++ SDIYVKGW+ G E++KQ+T
Sbjct: 1760 PPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSI-TGEEMSDIYVKGWIPGNEENKQKT 1818

Query: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700
            DVHY SL GEGNFNWRF+FPF YLPAE+  ++ K+E+ +S+++ E + P  L++Q+WD +
Sbjct: 1819 DVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDND 1878

Query: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDL-----AKFENASEETKISIFQQKRVRGWWP 1755
            + S DD+LG LE++L      AKS + C L      K  N  +    S+F+QK ++GWWP
Sbjct: 1879 KFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWP 1938

Query: 1756 FSKSKE----LTGKVEAEFHLVTAEEAEKNPVGKARKEPE---PLAKPNRPDTSFSWFMS 1808
                K+    + GKVE    ++  +EA++ P GK R EP     L  PNRP+TSF WF +
Sbjct: 1939 CYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTN 1998

Query: 1809 PFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
            P K + +++W+ +K  II    L+IL++F+ + +Y+LP  +S +IV
Sbjct: 1999 PCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044



 Score =  354 bits (909), Expect = 4e-97
 Identities = 250/782 (31%), Positives = 396/782 (50%), Gaps = 123/782 (15%)

Query: 25  KDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEV----RS 80
           ++ +GD + L +      GP+G          PV + S  + ++ LTK+ +       + 
Sbjct: 148 EEDEGDEDRL-DNAVRGPGPKG----------PVGTVSEAQLARRLTKVKNSRRMLSNKP 196

Query: 81  QNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVH 140
           Q++QI + + E RQL G NI PVV + +  +  ++ +K G N+PF++E F ++       
Sbjct: 197 QDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRG-NNPFFDELFFYNVNMTPSE 255

Query: 141 LFDKIIKISVFH-HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGY 199
           L D+II I V++ H L    L+G FK+D+G VY++PGH    KW LL DP D  +G+KGY
Sbjct: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGY 315

Query: 200 LKCDISVMGKGDVLKTSPKTSDTE-EPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKM 258
           +K  + V+G GD      +  D + + +E NLL+P G  L   W  F +++Y+AE +P+M
Sbjct: 316 MKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALR--WVTFLLKIYRAEDIPQM 373

Query: 259 NSSIMANVTKAFVG--DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPP 316
           + +    V + F G  D K+LVDPFVEVSFAG+   T + +  A+P W++ V  +  FP 
Sbjct: 374 DDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPS 433

Query: 317 LCRRVKIQV--WDEGSMNDVALATHFIDLKKIS--------NEQDGDKGFLPTFGPAWIN 366
           +C ++K+ +  WD  + NDV + T ++ L KI+        N  + + GF+PTFGP ++N
Sbjct: 434 VCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLN 492

Query: 367 LYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLP 425
           LYGSPR ++   D Y E+N G GEGV++RGRILVE+A  +                    
Sbjct: 493 LYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFL-------------------- 532

Query: 426 SKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAF 485
                          +KT   K  +    +N   + VE +        ++  ++ L   F
Sbjct: 533 ---------------EKTPPDKKLEPI--SNDDLLVVEKY--------QRRRKYSLSAVF 567

Query: 486 FEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAH 545
             ATM+ + +G+  I FEVSIGN+GN  D                               
Sbjct: 568 HSATML-QDVGE-AIQFEVSIGNYGNKFDTTCK--------------------------- 598

Query: 546 DVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMAD 605
               P+ASTT   +  V +GN  Y YLP+   KP V   S W D + RL   N L  MA+
Sbjct: 599 ----PLASTTQYSR-AVFDGN-YYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAE 652

Query: 606 FLEESIEEVRELI--KISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKR 663
            L+ +IE ++  I  KI      E    ++ + I  +   +   E K    N T LD + 
Sbjct: 653 RLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGK---ANVTVLDTQI 709

Query: 664 LTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWM 723
             L  + L  + + A   ++ + +   V   + E +++++K+  L +EPQ+++PD+ IWM
Sbjct: 710 RKLRSRSLSQIHEAA---VRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWM 766

Query: 724 LSNNRRVAYARIASKDLLYSPVA-GQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVYLW 782
           +   +R+AYARI +  +LYS       GK+CGK +T FLK P ++  G  V  ++ V +W
Sbjct: 767 IRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIW 826

Query: 783 LG 784
           LG
Sbjct: 827 LG 828



 Score = 38.1 bits (87), Expect = 0.080
 Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 11/120 (9%)

Query: 845 GLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYD 904
           G  DP   V F    + TK +   L+P WN++L F+   L G   + + S  ++V    D
Sbjct: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFD---LRGIPLDFSSSLGIIV---KD 71

Query: 905 SDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELL--QVPPS 962
            + +G+ + +G    A      DQ    P   Y  I   N  G D  A  +L+    PPS
Sbjct: 72  FETIGQNKLIGTATVALKDLTGDQSRSLP---YKLISLLNEKGQDTGATIDLVIGYDPPS 128



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 8/77 (10%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           AD   L DPF +V+F      T II +  +P WNQ++  N  +    V E       + +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV--NLQIKFPSVCE------KIKL 440

Query: 901 ELYDSDAVGKPEYLGAT 917
            +YD D + K + +G T
Sbjct: 441 TIYDWDRLTKNDVVGTT 457



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query: 101 DPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIG-SV 159
           DP+V++   DEKK++   +   +P +NE   FD  G  +  F   + I V   + IG + 
Sbjct: 21  DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD-FSSSLGIIVKDFETIGQNK 79

Query: 160 LIGSFKVDL 168
           LIG+  V L
Sbjct: 80  LIGTATVAL 88


>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score =  689 bits (1779), Expect = 0.0
 Identities = 393/1066 (36%), Positives = 585/1066 (54%), Gaps = 152/1066 (14%)

Query: 810  GTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTL 869
            G N P  +  +   +++ LR ++YQAR L+A D +  SDP+A + FL   +TT+II  TL
Sbjct: 1123 GANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTL 1182

Query: 870  SPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQD 929
            +PTW+Q ++F+++ ++G+ + + ++PP V++EL+D+D VGK E+LG ++ +PVVKL  + 
Sbjct: 1183 NPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM 1242

Query: 930  YEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVL 989
               P+L +HP+  G+ + GD+L   EL+     G   LP + P     +Y VP  IRPV+
Sbjct: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDG-SNLPILPPQRAPNLYMVPQGIRPVV 1301

Query: 990  SKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEV 1049
                +E+L WG+R MK  Q+ S+  P  ++ECGG+ V+S VI++ K  PNF       +V
Sbjct: 1302 QLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKV 1361

Query: 1050 ELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGH 1109
             LP+ EL  PPL I V+D R FGR  +VG  TI  L +F C            D      
Sbjct: 1362 FLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRC------------DPYAGKE 1409

Query: 1110 DISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEP 1169
            DI   L A+  S        PP   I +++E                     D+ P+L  
Sbjct: 1410 DIVPQLKASLLSA-------PPCRDIVIEME---------------------DTKPLLAS 1441

Query: 1170 EHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKE 1229
            + T                                E  E ++DWWSK+YAS  + +K  +
Sbjct: 1442 KLT--------------------------------EKEEEIVDWWSKFYASSGEHEKCGQ 1469

Query: 1230 RNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGIPNLAILQIYDGDLES--E 1287
               KG                                        + L+IY+ +LE+  E
Sbjct: 1470 YIQKG---------------------------------------YSKLKIYNCELENVAE 1490

Query: 1288 FNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLRIQQG 1347
            F    D+  TF+L+RGKS E++       V+G+FKGSF IY  P D S       R  + 
Sbjct: 1491 FEGLTDFSDTFKLYRGKSDENED----PSVVGEFKGSFRIYPLPDDPSVP--APPRQFRE 1544

Query: 1348 IPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGR 1407
            +P + P    +R+YIV    L P D +G  DPYI I LGK  I+DRD YIP  LNPVFGR
Sbjct: 1545 LPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGR 1604

Query: 1408 SFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGY 1467
             +E+    P+E  L I +YD+D    D+ +GET IDLENRF S+  + CG+  +Y + G 
Sbjct: 1605 MYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGV 1664

Query: 1468 NAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESY- 1524
            N WRD  +PT++L  + +      P       +I+ G + +S      E + ++ +  + 
Sbjct: 1665 NTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS----LDEFEANKILHQHL 1720

Query: 1525 ----EHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580
                E LAL +L +          LVPEH+ETR L+   +P + QG+LQMWVD+FPK + 
Sbjct: 1721 GAPEERLALHILRTQG--------LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLG 1772

Query: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640
             PGPP +I+PR+ K Y LRV IWNT+DVIL++++I TG++ SDIYVKGW+ G E++KQ+T
Sbjct: 1773 PPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSI-TGEEMSDIYVKGWIPGNEENKQKT 1831

Query: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700
            DVHY SL GEGNFNWRF+FPF YLPAE+  ++ K+E+ +S+++ E + P  L++Q+WD +
Sbjct: 1832 DVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDND 1891

Query: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDL-----AKFENASEETKISIFQQKRVRGWWP 1755
            + S DD+LG LE++L      AKS + C L      K  N  +    S+F+QK ++GWWP
Sbjct: 1892 KFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWP 1951

Query: 1756 FSKSKE----LTGKVEAEFHLVTAEEAEKNPVGKARKEPE---PLAKPNRPDTSFSWFMS 1808
                K+    + GKVE    ++  +EA++ P GK R EP     L  PNRP+TSF WF +
Sbjct: 1952 CYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTN 2011

Query: 1809 PFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854
            P K + +++W+ +K  II    L+IL++F+ + +Y+LP  +S +IV
Sbjct: 2012 PCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057



 Score =  349 bits (896), Expect = 1e-95
 Identities = 250/795 (31%), Positives = 396/795 (49%), Gaps = 136/795 (17%)

Query: 25  KDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEV----RS 80
           ++ +GD + L +      GP+G          PV + S  + ++ LTK+ +       + 
Sbjct: 148 EEDEGDEDRL-DNAVRGPGPKG----------PVGTVSEAQLARRLTKVKNSRRMLSNKP 196

Query: 81  QNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVH 140
           Q++QI + + E RQL G NI PVV + +  +  ++ +K G N+PF++E F ++       
Sbjct: 197 QDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRG-NNPFFDELFFYNVNMTPSE 255

Query: 141 LFDKIIKISVFH-HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGY 199
           L D+II I V++ H L    L+G FK+D+G VY++PGH    KW LL DP D  +G+KGY
Sbjct: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGY 315

Query: 200 LKCDISVMGKGDVLKTSPKTSDTE-EPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKM 258
           +K  + V+G GD      +  D + + +E NLL+P G  L   W  F +++Y+AE +P+M
Sbjct: 316 MKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALR--WVTFLLKIYRAEDIPQM 373

Query: 259 NSSIMANVTKAFVG--DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPP 316
           + +    V + F G  D K+LVDPFVEVSFAG+   T + +  A+P W++ V  +  FP 
Sbjct: 374 DDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPS 433

Query: 317 LCRRVKIQV--WDEGSMNDVALATHFIDLKKIS---------------------NEQDGD 353
           +C ++K+ +  WD  + NDV + T ++ L KI+                     N  + +
Sbjct: 434 VCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETE 492

Query: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412
            GF+PTFGP ++NLYGSPR ++   D Y E+N G GEGV++RGRILVE+A  +       
Sbjct: 493 VGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFL------- 545

Query: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472
                                       +KT   K  +    +N   + VE +       
Sbjct: 546 ----------------------------EKTPPDKKLEPI--SNDDLLVVEKY------- 568

Query: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532
            ++  ++ L   F  ATM+ + +G+  I FEVSIGN+GN  D                  
Sbjct: 569 -QRRRKYSLSAVFHSATML-QDVGE-AIQFEVSIGNYGNKFDTTCK-------------- 611

Query: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592
                            P+ASTT   +  V +GN  Y YLP+   KP V   S W D + 
Sbjct: 612 -----------------PLASTTQYSR-AVFDGN-YYYYLPWAHTKPVVTLTSYWEDISH 652

Query: 593 RLHWSNMLEKMADFLEESIEEVRELI--KISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650
           RL   N L  MA+ L+ +IE ++  I  KI      E    ++ + I  +   +   E K
Sbjct: 653 RLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGK 712

Query: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVD 710
               N T LD +   L  + L  + + A   ++ + +   V   + E +++++K+  L +
Sbjct: 713 ---ANVTVLDTQIRKLRSRSLSQIHEAA---VRMRSEATDVKSTLAEIEDWLDKLMQLTE 766

Query: 711 EPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVA-GQMGKHCGKIKTHFLKPPGKRPA 769
           EPQ+++PD+ IWM+   +R+AYARI +  +LYS       GK+CGK +T FLK P ++  
Sbjct: 767 EPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNN 826

Query: 770 GWSVQAKVDVYLWLG 784
           G  V  ++ V +WLG
Sbjct: 827 GPKVPVELRVNIWLG 841



 Score = 38.1 bits (87), Expect = 0.080
 Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 11/120 (9%)

Query: 845 GLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYD 904
           G  DP   V F    + TK +   L+P WN++L F+   L G   + + S  ++V    D
Sbjct: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFD---LRGIPLDFSSSLGIIV---KD 71

Query: 905 SDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELL--QVPPS 962
            + +G+ + +G    A      DQ    P   Y  I   N  G D  A  +L+    PPS
Sbjct: 72  FETIGQNKLIGTATVALKDLTGDQSRSLP---YKLISLLNEKGQDTGATIDLVIGYDPPS 128



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 8/77 (10%)

Query: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900
           AD   L DPF +V+F      T II +  +P WNQ++  N  +    V E       + +
Sbjct: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV--NLQIKFPSVCE------KIKL 440

Query: 901 ELYDSDAVGKPEYLGAT 917
            +YD D + K + +G T
Sbjct: 441 TIYDWDRLTKNDVVGTT 457



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query: 101 DPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIG-SV 159
           DP+V++   DEKK++   +   +P +NE   FD  G  +  F   + I V   + IG + 
Sbjct: 21  DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD-FSSSLGIIVKDFETIGQNK 79

Query: 160 LIGSFKVDL 168
           LIG+  V L
Sbjct: 80  LIGTATVAL 88


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  426 bits (1095), Expect = e-118
 Identities = 248/669 (37%), Positives = 362/669 (54%), Gaps = 79/669 (11%)

Query: 1199 KRTIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKK 1258
            K + A++  E+ +DWWSK + +  +                                   
Sbjct: 118  KSSKAEDEYEHEVDWWSKLFWATDE----------------------------------- 142

Query: 1259 DKMLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDR 1316
             K LK K KD        L++Y+ +LE+   F   +D+ +TF+L++ +   D        
Sbjct: 143  HKSLKYKYKD-----YHTLKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP------ 191

Query: 1317 VIGKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGK 1376
            V+G+FKG F IY  P++  +       +      + P   L+RVY+V A NL P D +G 
Sbjct: 192  VVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGL 251

Query: 1377 SDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDL 1436
             DPY+++KLGKTE+ +RD Y P  L+P+FG  FE+    P E  L I +YD D+   DD 
Sbjct: 252  CDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDK 311

Query: 1437 IGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP 1496
            IG T IDLENR  S   A CGL   Y   G   WRD   P+ +L +  K   L  P F P
Sbjct: 312  IGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSP 371

Query: 1497 GKIQIGNQVFSGKTIFTEEDTDETVESY------EHLALKVLHSWEDIPEVGCRLVPEHI 1550
             +  +    ++GK    +    +T   +      E LAL +LH+          LVPEH+
Sbjct: 372  EEDAV---FYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQG--------LVPEHV 420

Query: 1551 ETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVIL 1610
            ETR LY   +PG++QG++QMWVD+FPK +  PGP V+I+PR+PK YELR  IW T +V L
Sbjct: 421  ETRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWKTANVDL 480

Query: 1611 EDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQM 1670
             D+N+ + +K+SDIY+KGWL GLE D Q+TD+HY+SLTGE +FNWRF+F   YL AE+  
Sbjct: 481  VDDNL-SREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAERTC 539

Query: 1671 VITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDL 1730
            V ++++ I+SL+    K PA L++QVWD +  S DDFLG LE++L+  P  A+ AK C +
Sbjct: 540  VQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQCSI 599

Query: 1731 ------AKFENASEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFHLVTAEEAEK 1780
                   K+    +    S+F++K V GWWP          L+GKV+    +++ +EA  
Sbjct: 600  RMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEILSEKEALI 659

Query: 1781 NPVGKARKEPE---PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIF 1837
             P G+ + EP     L  P R +TSF+W  SP +   Y+ WK Y+  +I   ++ I+ + 
Sbjct: 660  KPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIALM 719

Query: 1838 LVLFIYTLP 1846
            L  FIY+ P
Sbjct: 720  LFNFIYSAP 728



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 2/78 (2%)

Query: 1015 PQALIECGGQGVKSCVIQSYKNNPNF--SIQADAFEVELPENELLHPPLSICVVDWRAFG 1072
            PQ L+E G + +++  I+ ++ NPNF  S       V +P  E    PL + VVD  AFG
Sbjct: 7    PQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVVDNWAFG 66

Query: 1073 RSTLVGTYTINYLKQFLC 1090
            + T+ G   I++L+ + C
Sbjct: 67   QQTVTGQANIDFLQPYFC 84


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score =  418 bits (1075), Expect = e-116
 Identities = 248/678 (36%), Positives = 362/678 (53%), Gaps = 88/678 (12%)

Query: 1199 KRTIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKK 1258
            K + A++  E+ +DWWSK + +  +                                   
Sbjct: 1400 KSSKAEDEYEHEVDWWSKLFWATDE----------------------------------- 1424

Query: 1259 DKMLKKKPKDDGIPNLAILQIYDGDLES--EFNNFEDWVKTFELFRGKSTEDDHGLDGDR 1316
             K LK K KD        L++Y+ +LE+   F   +D+ +TF+L++ +   D        
Sbjct: 1425 HKSLKYKYKD-----YHTLKVYECELEAVPAFQGLQDFCQTFKLYQEQPKLDSP------ 1473

Query: 1317 VIGKFKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGK 1376
            V+G+FKG F IY  P++  +       +      + P   L+RVY+V A NL P D +G 
Sbjct: 1474 VVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQDYNGL 1533

Query: 1377 SDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDL 1436
             DPY+++KLGKTE+ +RD Y P  L+P+FG  FE+    P E  L I +YD D+   DD 
Sbjct: 1534 CDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLFSPDDK 1593

Query: 1437 IGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP 1496
            IG T IDLENR  S   A CGL   Y   G   WRD   P+ +L +  K   L  P F P
Sbjct: 1594 IGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPPPLFSP 1653

Query: 1497 GKIQIGNQVFSGKTIFTEEDTDETVESY------EHLALKVLHSWEDIPEVGCRLVPEHI 1550
             +  +    ++GK    +    +T   +      E LAL +LH+          LVPEH+
Sbjct: 1654 EEDAV---FYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQG--------LVPEHV 1702

Query: 1551 ETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKG---------YELRVT 1601
            ETR LY   +PG++QG++QMWVD+FPK +  PGP V+I+PR+PK          YELR  
Sbjct: 1703 ETRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCI 1762

Query: 1602 IWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPF 1661
            IW T +V L D+N+ + +K+SDIY+KGWL GLE D Q+TD+HY+SLTGE +FNWRF+F  
Sbjct: 1763 IWKTANVDLVDDNL-SREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTM 1821

Query: 1662 QYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRA 1721
             YL AE+  V ++++ I+SL+    K PA L++QVWD +  S DDFLG LE++L+  P  
Sbjct: 1822 DYLAAERTCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLP 1881

Query: 1722 AKSAKACDL------AKFENASEETKISIFQQKRVRGWWPF----SKSKELTGKVEAEFH 1771
            A+ AK C +       K+    +    S+F++K V GWWP          L+GKV+    
Sbjct: 1882 ARHAKQCSIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLE 1941

Query: 1772 LVTAEEAEKNPVGKARKEPE---PLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIA 1828
            +++ +EA   P G+ + EP     L  P R +TSF+W  SP +   Y+ WK Y+  +I  
Sbjct: 1942 ILSEKEALIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAF 2001

Query: 1829 FILIILIIFLVLFIYTLP 1846
             ++ I+ + L  FIY+ P
Sbjct: 2002 MVISIIALMLFNFIYSAP 2019



 Score =  211 bits (536), Expect = 7e-54
 Identities = 187/732 (25%), Positives = 327/732 (44%), Gaps = 156/732 (21%)

Query: 79  RSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQ 138
           + Q++Q+ + + EARQL+G NI PVV + I  ++ Q+ +K G N+PF+NE F  +F    
Sbjct: 163 KPQHFQVRVKVFEARQLMGNNIKPVVKVSIAGQQHQTRIKMG-NNPFFNEIFFQNFHEVP 221

Query: 139 VHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKG 198
              FD+ I I                + D+G +Y+ PGH    KW  L  P +  +G  G
Sbjct: 222 AKFFDETILI----------------QTDIGFIYHSPGHTLLRKWLGLCQPNNPGSGVTG 265

Query: 199 YLKCDISVMGKGDVLKTSPK----TSDTEEPIEKNLLIPNGFPLERPWARFYVRLYKAEG 254
           YLK  I  +G GD      K    T DT+  I K+ ++P         A   + +Y AE 
Sbjct: 266 YLKVTIYALGVGDQALIDQKLLYGTDDTDIQIFKSAVVPINM------AYLQLFIYCAED 319

Query: 255 LP-KMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEM 313
           L  K + S                V+P +EV   G+  RT +Q    +P+W++ + F+  
Sbjct: 320 LHLKKHQS----------------VNPQLEVELIGEKLRTHMQTQTDNPIWNQILTFRIQ 363

Query: 314 FPPLCRRVKIQVWDEGSMN-DVALATHFIDLKKISN---EQDGDK-------------GF 356
            P L   +K +V D    +    + T  + L +IS+   E +G +             GF
Sbjct: 364 LPCLSSYIKFRVLDCRKKDCPDEIGTASLSLNQISSTGEEIEGKQSLEPTSYTPRVYSGF 423

Query: 357 LPTFGPAWINLYGSPR-NHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKF 415
           LP FGP+++ L+G  +    + ++   + +   +G+++RGR+ +E+  +I          
Sbjct: 424 LPCFGPSFLTLHGGKKAPFRIQEEGACIPDSVRDGLAYRGRVFLELITQI---------- 473

Query: 416 SKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEK 475
                        K  + S  KD + +               T +E            + 
Sbjct: 474 -------------KSYQDSTIKDLSHEV--------------TRIEKH----------QN 496

Query: 476 NEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPL 535
            +++ L   F   TM+      + I FEVSIG++GN +D                     
Sbjct: 497 RQKYGLCVIFLSCTMMPN--FKELIHFEVSIGHYGNKMDLNYK----------------- 537

Query: 536 LHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLH 595
                         P+ S+T P  P++ +GN  Y+Y+P+   KP V   S+W D +FR++
Sbjct: 538 --------------PLVSST-PYSPVIYDGN-IYHYVPWYNTKPVVAVTSNWEDVSFRMN 581

Query: 596 WSNMLEKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLN 655
             N+L    D L+ +++ ++        A   + + +L +        +     +PK   
Sbjct: 582 CLNLLHFTRDRLKANLDTLKSTRNPKDPALLYQWEKLLRELAEDCKRPLPCMTYQPK--- 638

Query: 656 QTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHT 715
            T+LD+KR    WQ    + +E    + Q+ K+    +M+  A++++ ++  ++ EPQ  
Sbjct: 639 ATSLDRKR----WQLRSLLLQE----LAQKAKQAKPKDMVATAEDWLYRLNTVLPEPQMG 690

Query: 716 IPDVFIWMLSNNRRVAYARIASKDLLYSPV-AGQMGKHCGKIKTHFLKPPGKRPAGWSVQ 774
           +PDV IW+++  +RVAYA++ +  +L+SP  A   G+ CGKI+T FL+ P        + 
Sbjct: 691 LPDVMIWLVAKEQRVAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKDVLP 750

Query: 775 AKVDVYLWLGSI 786
           A + V +WLG++
Sbjct: 751 AHLRVCMWLGNV 762



 Score =  159 bits (402), Expect = 2e-38
 Identities = 96/275 (34%), Positives = 149/275 (54%), Gaps = 9/275 (3%)

Query: 820  YQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLF 879
            + + H +QL  ++YQAR L++        PF +V FL+H Q T+ +  +  PTW Q L+F
Sbjct: 1097 FNKPHYYQLFCYIYQARNLVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIF 1156

Query: 880  NDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHP 939
              L+L+ + ++  ESPPLVV+EL+  D  GK    G +V  P+V L  QD   P + +HP
Sbjct: 1157 QHLLLYENPQDTKESPPLVVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHP 1216

Query: 940  IFCG-NLSGGDLLAVFEL-LQVPPSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVL 997
            +        G++LA  EL LQ    G + LP +  P     Y +P +I+P + +  +E+L
Sbjct: 1217 LVKELGKEEGEILASCELILQTEKLGEKQLPILSVPWKNGAYTLPKSIQPTIKRMAIEIL 1276

Query: 998  FWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNF--SIQADAFEVELPENE 1055
             WG+R MKK        PQ L+E G + +++  I+ ++ NPNF  S       V +P  E
Sbjct: 1277 AWGLRNMKK-----ASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEE 1331

Query: 1056 LLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLC 1090
                PL + VVD  AFG+ T+ G   I++L+ + C
Sbjct: 1332 AYALPLVVKVVDNWAFGQQTVTGQANIDFLQPYFC 1366


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 34/94 (36%), Positives = 52/94 (55%), Gaps = 9/94 (9%)

Query: 828 LRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGD 887
           LR H+  AR L   D +G SDPFA+V + S    T  I +T  P W+++L         +
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVL---------E 185

Query: 888 VKELAESPPLVVVELYDSDAVGKPEYLGATVAAP 921
           ++E+  +P  + VEL+D D VGK ++LG    +P
Sbjct: 186 LREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSP 219



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 2/88 (2%)

Query: 1358 IRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPK 1417
            + V +V    L   D  G SDPY ++K+   E+  R   + + L P +G  + +      
Sbjct: 7    LNVRVVEGRALPAKDVSGSSDPYCLVKVDD-EVVARTATVWRSLGPFWGEEYTVHLPLDF 65

Query: 1418 ESLLSILIYDHDMIGTDDLIGETKIDLE 1445
              L +  + D D +G DD+IG+  +  E
Sbjct: 66   HQL-AFYVLDEDTVGHDDIIGKISLSRE 92



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 36/155 (23%), Positives = 65/155 (41%), Gaps = 14/155 (9%)

Query: 1284 LESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLR 1343
            L+ +    +D +    L R   T D  G+D             I  S  D  +E  G++ 
Sbjct: 73   LDEDTVGHDDIIGKISLSREAITADPRGIDS-----------WINLSRVDPDAEVQGEIC 121

Query: 1344 IQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNP 1403
            +   +  +     L R +++ A +L+P D  G SDP+  +  G   ++     I K   P
Sbjct: 122  LSVQMLEDGQGRCL-RCHVLHARDLAPRDISGTSDPFARVFWGSQSLE--TSTIKKTRFP 178

Query: 1404 VFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIG 1438
             +    E++      S L + ++D DM+G +D +G
Sbjct: 179  HWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLG 213


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 68/281 (24%), Positives = 117/281 (41%), Gaps = 52/281 (18%)

Query: 809  AGTNHPPSNLLYQEQHVF---QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQ---TT 862
            AGT  P   + +  ++++   QL   + QA  L A DSNG SDP+ K+  L   +    T
Sbjct: 294  AGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQT 353

Query: 863  KIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPV 922
            K+  +TL+P +N+   F+       + ELA+    +   +YD D   + + +G  V   +
Sbjct: 354  KVHRKTLNPVFNETFQFS-----VPLAELAQRK--LHFSVYDFDRFSRHDLIGQVVLDNL 406

Query: 923  VKLADQDYEPPRLCYHPIFCGNLSGGDLLAV-FELLQVPPSGLQGLPPVEPPDITQIYPV 981
            ++LA+Q   P R  +  I  G     DL  + F L  +P +G                  
Sbjct: 407  LELAEQ--PPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAG------------------ 446

Query: 982  PANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRP--QALIECGGQGVKSCVIQSYKN--N 1037
                       R+ V       +K + L     P  +A +   G+ +K       KN  N
Sbjct: 447  -----------RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 1038 PNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVG 1078
            P ++   +A   ++    + +  LSI VVD+   G + ++G
Sbjct: 496  PTYN---EALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 3/87 (3%)

Query: 1360 VYIVAAFNLSPADPDGKSDPYIVIKL-GKTEIKDRDKYIPKQLNPVFGRSFEIQATFPK- 1417
            V I+ A +L   D +G SDPY+ I L    + K + K   K LNPVF  +F+      + 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAEL 377

Query: 1418 -ESLLSILIYDHDMIGTDDLIGETKID 1443
             +  L   +YD D     DLIG+  +D
Sbjct: 378  AQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 5/95 (5%)

Query: 1353 PVTVLIRVYIVAAFNLSPADPDGKSDPYI---VIKLGKTEIKDRDKYIPKQLNPVFGRS- 1408
            P    + V I+ A NL   D  G SDPY+   +I  G+   K +       LNP +  + 
Sbjct: 443  PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEAL 502

Query: 1409 -FEIQATFPKESLLSILIYDHDMIGTDDLIGETKI 1442
             F++     +   LSI + D+D IG +++IG  ++
Sbjct: 503  VFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 827 QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQT-----TKIISQTLSPTWNQMLLFND 881
           +L   + +A  L A D  G SDP+ K + +S  +      T I   TL+PT+N+ L+F+ 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFD- 505

Query: 882 LVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAP 921
            V    V+ +  S     + + D D +G  E +G     P
Sbjct: 506 -VAPESVENVGLS-----IAVVDYDCIGHNEVIGVCRVGP 539



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 13/97 (13%)

Query: 84  QIAITITEARQLVGENI----DPVVTIEIGDE-----KKQSTVKEGTNSPFYNEYFVFDF 134
           ++ +TI +A  L   ++    DP V   +  E     K+++++K+ T +P YNE  VFD 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDV 506

Query: 135 IGPQVHLFDKIIKI----SVFHHKLIGSVLIGSFKVD 167
               V      I +     + H+++IG   +G    D
Sbjct: 507 APESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD 543


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 68/281 (24%), Positives = 117/281 (41%), Gaps = 52/281 (18%)

Query: 809  AGTNHPPSNLLYQEQHVF---QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQ---TT 862
            AGT  P   + +  ++++   QL   + QA  L A DSNG SDP+ K+  L   +    T
Sbjct: 294  AGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQT 353

Query: 863  KIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPV 922
            K+  +TL+P +N+   F+       + ELA+    +   +YD D   + + +G  V   +
Sbjct: 354  KVHRKTLNPVFNETFQFS-----VPLAELAQRK--LHFSVYDFDRFSRHDLIGQVVLDNL 406

Query: 923  VKLADQDYEPPRLCYHPIFCGNLSGGDLLAV-FELLQVPPSGLQGLPPVEPPDITQIYPV 981
            ++LA+Q   P R  +  I  G     DL  + F L  +P +G                  
Sbjct: 407  LELAEQ--PPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAG------------------ 446

Query: 982  PANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRP--QALIECGGQGVKSCVIQSYKN--N 1037
                       R+ V       +K + L     P  +A +   G+ +K       KN  N
Sbjct: 447  -----------RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 1038 PNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVG 1078
            P ++   +A   ++    + +  LSI VVD+   G + ++G
Sbjct: 496  PTYN---EALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 3/87 (3%)

Query: 1360 VYIVAAFNLSPADPDGKSDPYIVIKL-GKTEIKDRDKYIPKQLNPVFGRSFEIQATFPK- 1417
            V I+ A +L   D +G SDPY+ I L    + K + K   K LNPVF  +F+      + 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAEL 377

Query: 1418 -ESLLSILIYDHDMIGTDDLIGETKID 1443
             +  L   +YD D     DLIG+  +D
Sbjct: 378  AQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 5/95 (5%)

Query: 1353 PVTVLIRVYIVAAFNLSPADPDGKSDPYI---VIKLGKTEIKDRDKYIPKQLNPVFGRS- 1408
            P    + V I+ A NL   D  G SDPY+   +I  G+   K +       LNP +  + 
Sbjct: 443  PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEAL 502

Query: 1409 -FEIQATFPKESLLSILIYDHDMIGTDDLIGETKI 1442
             F++     +   LSI + D+D IG +++IG  ++
Sbjct: 503  VFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 827 QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQT-----TKIISQTLSPTWNQMLLFND 881
           +L   + +A  L A D  G SDP+ K + +S  +      T I   TL+PT+N+ L+F+ 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFD- 505

Query: 882 LVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAP 921
            V    V+ +  S     + + D D +G  E +G     P
Sbjct: 506 -VAPESVENVGLS-----IAVVDYDCIGHNEVIGVCRVGP 539



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 13/97 (13%)

Query: 84  QIAITITEARQLVGENI----DPVVTIEIGDE-----KKQSTVKEGTNSPFYNEYFVFDF 134
           ++ +TI +A  L   ++    DP V   +  E     K+++++K+ T +P YNE  VFD 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDV 506

Query: 135 IGPQVHLFDKIIKI----SVFHHKLIGSVLIGSFKVD 167
               V      I +     + H+++IG   +G    D
Sbjct: 507 APESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD 543


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 68/281 (24%), Positives = 117/281 (41%), Gaps = 52/281 (18%)

Query: 809  AGTNHPPSNLLYQEQHVF---QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQ---TT 862
            AGT  P   + +  ++++   QL   + QA  L A DSNG SDP+ K+  L   +    T
Sbjct: 294  AGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQT 353

Query: 863  KIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPV 922
            K+  +TL+P +N+   F+       + ELA+    +   +YD D   + + +G  V   +
Sbjct: 354  KVHRKTLNPVFNETFQFS-----VPLAELAQRK--LHFSVYDFDRFSRHDLIGQVVLDNL 406

Query: 923  VKLADQDYEPPRLCYHPIFCGNLSGGDLLAV-FELLQVPPSGLQGLPPVEPPDITQIYPV 981
            ++LA+Q   P R  +  I  G     DL  + F L  +P +G                  
Sbjct: 407  LELAEQ--PPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAG------------------ 446

Query: 982  PANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRP--QALIECGGQGVKSCVIQSYKN--N 1037
                       R+ V       +K + L     P  +A +   G+ +K       KN  N
Sbjct: 447  -----------RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLN 495

Query: 1038 PNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVG 1078
            P ++   +A   ++    + +  LSI VVD+   G + ++G
Sbjct: 496  PTYN---EALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 3/87 (3%)

Query: 1360 VYIVAAFNLSPADPDGKSDPYIVIKL-GKTEIKDRDKYIPKQLNPVFGRSFEIQATFPK- 1417
            V I+ A +L   D +G SDPY+ I L    + K + K   K LNPVF  +F+      + 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAEL 377

Query: 1418 -ESLLSILIYDHDMIGTDDLIGETKID 1443
             +  L   +YD D     DLIG+  +D
Sbjct: 378  AQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 5/95 (5%)

Query: 1353 PVTVLIRVYIVAAFNLSPADPDGKSDPYI---VIKLGKTEIKDRDKYIPKQLNPVFGRS- 1408
            P    + V I+ A NL   D  G SDPY+   +I  G+   K +       LNP +  + 
Sbjct: 443  PTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEAL 502

Query: 1409 -FEIQATFPKESLLSILIYDHDMIGTDDLIGETKI 1442
             F++     +   LSI + D+D IG +++IG  ++
Sbjct: 503  VFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 12/100 (12%)

Query: 827 QLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQT-----TKIISQTLSPTWNQMLLFND 881
           +L   + +A  L A D  G SDP+ K + +S  +      T I   TL+PT+N+ L+F+ 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFD- 505

Query: 882 LVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAP 921
            V    V+ +  S     + + D D +G  E +G     P
Sbjct: 506 -VAPESVENVGLS-----IAVVDYDCIGHNEVIGVCRVGP 539



 Score = 32.3 bits (72), Expect = 4.4
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 13/97 (13%)

Query: 84  QIAITITEARQLVGENI----DPVVTIEIGDE-----KKQSTVKEGTNSPFYNEYFVFDF 134
           ++ +TI +A  L   ++    DP V   +  E     K+++++K+ T +P YNE  VFD 
Sbjct: 447 RLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDV 506

Query: 135 IGPQVHLFDKIIKI----SVFHHKLIGSVLIGSFKVD 167
               V      I +     + H+++IG   +G    D
Sbjct: 507 APESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAAD 543


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 9/137 (6%)

Query: 1336 SEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKL---GKTEIKD 1392
            +E  G++ IQ  I  +    VLI V +  A NL P DP+G SDPY+ +KL    K+E K 
Sbjct: 156  TERRGRIYIQAHIDRD----VLI-VLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210

Query: 1393 RDKYIPKQLNPVFGRSFEIQ-ATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSK 1451
            + K I   LNP +  +F  Q     K+  LS+ I+D D+   +D +G     +     + 
Sbjct: 211  KTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS 270

Query: 1452 HRAICGLQSQYEIEGYN 1468
                  L SQ E E +N
Sbjct: 271  VDGWFKLLSQEEGEYFN 287



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 16/115 (13%)

Query: 810 GTNHPPSN-LLYQEQHVFQ--LRAHMYQARGLIAADSNGLSDPFAKVTFL-----SHCQT 861
           GT+H      +Y + H+ +  L   +  A+ L+  D NGLSDP+ K+  +        Q 
Sbjct: 152 GTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK 211

Query: 862 TKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGA 916
           TK I  +L+P WN+   F        +KE ++    + VE++D D   + +++G+
Sbjct: 212 TKTIKCSLNPEWNETFRF-------QLKE-SDKDRRLSVEIWDWDLTSRNDFMGS 258



 Score = 34.7 bits (78), Expect = 0.89
 Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 22/101 (21%)

Query: 1622 SDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSL 1681
            SD YVK  LK + D K E+     ++    N  W   F FQ   ++K   ++        
Sbjct: 192  SDPYVK--LKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLS-------- 241

Query: 1682 EKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAA 1722
                        +++WD++  S +DF+G+L   ++   +A+
Sbjct: 242  ------------VEIWDWDLTSRNDFMGSLSFGISELQKAS 270


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 9/137 (6%)

Query: 1336 SEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKL---GKTEIKD 1392
            +E  G++ IQ  I  +    VLI V +  A NL P DP+G SDPY+ +KL    K+E K 
Sbjct: 156  TERRGRIYIQAHIDRD----VLI-VLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQ 210

Query: 1393 RDKYIPKQLNPVFGRSFEIQ-ATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSK 1451
            + K I   LNP +  +F  Q     K+  LS+ I+D D+   +D +G     +     + 
Sbjct: 211  KTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAS 270

Query: 1452 HRAICGLQSQYEIEGYN 1468
                  L SQ E E +N
Sbjct: 271  VDGWFKLLSQEEGEYFN 287



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 16/115 (13%)

Query: 810 GTNHPPSN-LLYQEQHVFQ--LRAHMYQARGLIAADSNGLSDPFAKVTFL-----SHCQT 861
           GT+H      +Y + H+ +  L   +  A+ L+  D NGLSDP+ K+  +        Q 
Sbjct: 152 GTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQK 211

Query: 862 TKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGA 916
           TK I  +L+P WN+   F        +KE ++    + VE++D D   + +++G+
Sbjct: 212 TKTIKCSLNPEWNETFRF-------QLKE-SDKDRRLSVEIWDWDLTSRNDFMGS 258



 Score = 34.7 bits (78), Expect = 0.89
 Identities = 24/101 (23%), Positives = 44/101 (43%), Gaps = 22/101 (21%)

Query: 1622 SDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSL 1681
            SD YVK  LK + D K E+     ++    N  W   F FQ   ++K   ++        
Sbjct: 192  SDPYVK--LKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLS-------- 241

Query: 1682 EKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAA 1722
                        +++WD++  S +DF+G+L   ++   +A+
Sbjct: 242  ------------VEIWDWDLTSRNDFMGSLSFGISELQKAS 270


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 21/160 (13%)

Query: 1303 GKSTEDDHGLDGDRVIGKFK-GSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVY 1361
            G S+    G  G   + K K GS      P D +   S  +  +  +  N+ +  LI ++
Sbjct: 4658 GSSSVPSPGQPGSPSVSKKKHGS----SKPTDGTKVVSHPITGEIQLQINYDLGNLI-IH 4712

Query: 1362 IVAAFNLSPADPDGKSDPYI------------VIKLGKTEIKDRDKYIPKQLNPVFGRSF 1409
            I+ A NL P D +G SDP++            V++    E K R K++ K LNP + ++ 
Sbjct: 4713 ILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTV 4772

Query: 1410 ---EIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLEN 1446
                I     K+  L + ++D+D   ++D +GE  IDL +
Sbjct: 4773 IYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSS 4812



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 29/99 (29%), Positives = 48/99 (48%), Gaps = 20/99 (20%)

Query: 831  HMYQARGLIAADSNGLSDPFAKVTFL--------------SHCQTTKIISQTLSPTWNQM 876
            H+ QAR L+  D+NG SDPF KV  L               + + TK + ++L+P WNQ 
Sbjct: 4712 HILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQT 4771

Query: 877  LLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLG 915
            +++  + +    K+  E      V ++D D     ++LG
Sbjct: 4772 VIYKSISMEQLKKKTLE------VTVWDYDRFSSNDFLG 4804



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 22/53 (41%), Positives = 34/53 (64%), Gaps = 6/53 (11%)

Query: 1665 PAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNS 1717
            P   Q VI K     S+E+++ KT   L + VWD++R SS+DFLG + ++L+S
Sbjct: 4766 PEWNQTVIYKS---ISMEQLKKKT---LEVTVWDYDRFSSNDFLGEVLIDLSS 4812



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 20/144 (13%)

Query: 375  SLMDDY-QEMNEGFGEGVSFRGRILVEIAV-EILSGRAQESKFSKALKELKLPSKDKDSK 432
            S  D+Y QE ++G GE   F  + ++E++  E  SG   +      LKE+   ++ +  +
Sbjct: 1536 SSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKE 1595

Query: 433  SSKGKDK---------ADKTEDGKSQQASNKTNSTEVEVESFDVPPEI-----VPEKNEE 478
             +KGK K           K+     + A  + +  + + E+FD  PE+       +++EE
Sbjct: 1596 ETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEE 1655

Query: 479  FLLFGA----FFEATMIDRKIGDK 498
             ++ G      F+   ++  I DK
Sbjct: 1656 LVVTGGGGLRRFKTIELNSTIADK 1679


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,952,263
Number of Sequences: 37866
Number of extensions: 3851248
Number of successful extensions: 15601
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 13768
Number of HSP's gapped (non-prelim): 1540
length of query: 1857
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1740
effective length of database: 13,817,196
effective search space: 24041921040
effective search space used: 24041921040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.